CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Astragalus Bicuspis

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO12927
Plant Latin Name: Astragalus Bicuspis
Taxonomy Genus: Astragalus
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

12 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

5 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

9 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC87545

Ingredient ID: NPC475388

Ingredient ID: NPC473726

Ingredient ID: NPC39426

Ingredient ID: NPC313163

Ingredient ID: NPC243728

Ingredient ID: NPC234333

Ingredient ID: NPC175

Ingredient ID: NPC161749

Ingredient ID: NPC16050

Ingredient ID: NPC154429

Ingredient ID: NPC1517

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Enzyme	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Therapeutic Target	Nuclear hormone receptor subfamily 3	ESRRA	Estrogen-related receptor alpha	P11474	CHEMBL3429
Therapeutic Target	Nuclear hormone receptor subfamily 3	ESRRB	Estrogen-related receptor beta	O95718	CHEMBL3751
Therapeutic Target	Nuclear hormone receptor subfamily 3	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Therapeutic Target	Nuclear hormone receptor subfamily 3	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Therapeutic Target	Oxidoreductase	ALDH2	Aldehyde dehydrogenase	P05091	CHEMBL1935
Therapeutic Target	Oxidoreductase	AOX1	Aldehyde oxidase	Q06278	CHEMBL3257
Therapeutic Target	Protein Kinase	MAP2K4	Dual specificity mitogen-activated protein kinase kinase 4	P45985	CHEMBL2897
Therapeutic Target	Serine protease	DPP4	Dipeptidyl peptidase IV	P27487	CHEMBL284

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	24

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT02766478	Genistein Supplementation to Mitigate Cardiometabolic Dysfunction in Patients Undergoing Androgen Deprivation Therapy for Prostate Cancer	prostate cancer	Genistein (NPC39426)	NP level
NCT00287690	Isoflavones and the Coronary Circulation in Men and Women With Coronary Artery Disease	coronary artery disease	Genistein (NPC39426)	NP level
NCT01664650	Effects of Genistein in Postmenopausal Women With Metabolic Syndrome	metabolic syndrome	Genistein (NPC39426)	NP level
NCT01325311	Cholecalciferol and Genistein Before Surgery in Treating Patients With Early Stage Prostate Cancer	prostate adenocarcinoma	Genistein (NPC39426)	NP level
NCT00118040	Phase II Study of Isoflavone G-2535 (Genistein) in Patients With Bladder Cancer	urinary bladder carcinoma	Genistein (NPC39426)	NP level
NCT01985763	Genistein in Treatment of Metastatic Colorectal Cancer	colorectal carcinoma;malignant colon neoplasm;rectum cancer	Genistein (NPC39426)	NP level
NCT00882765	Genistein in Treating Patients With Pancreatic Cancer That Can Be Removed by Surgery	pancreatic carcinoma	Genistein (NPC39426)	NP level
NCT00005827	Genistein in Treating Patients With Stage II, Stage III, or Stage IV Prostate Cancer	prostate cancer	Genistein (NPC39426)	NP level
NCT02567799	BIO 300 Non-Small Cell Lung Cancer Study	non-small cell lung carcinoma	Genistein (NPC39426)	NP level
NCT00016744	Phenylbutyrate/Genistein Duotherapy in Delta F508-Homozygous(for Cystic Fibrosis)	cystic fibrosis	Genistein (NPC39426)	NP level
NCT00546039	Synthetic Genistein (BONISTEIN™) in Patients Who Are Undergoing Surgery for Prostate Cancer	prostate adenocarcinoma	Genistein (NPC39426)	NP level
NCT00001696	A Pharmacokinetic Study of Genistein, a Tyrosine Kinase Inhibitor	cancer	Genistein (NPC39426)	NP level
NCT01126879	Genistein in Treating Patients With Prostate Cancer	prostate adenocarcinoma	Genistein (NPC39426)	NP level
NCT01628471	MTD Determination, Safety and Efficacy of the Decitabine-Genistein Drug Combination in Advanced Solid Tumors and Non-Small Cell Lung Cancer	non-small cell lung carcinoma	Genistein (NPC39426)	NP level
NCT00010686	Dietary Phytoestrogens and Bone Metabolism	osteoporosis	Genistein (NPC39426)	NP level
NCT01489813	Study of Genistein in Reducing Side Effects of Superficial Bladder Cancer Treatment	urinary bladder cancer	Genistein (NPC39426)	NP level
NCT00376948	Genistein, Gemcitabine, and Erlotinib in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer	pancreatic carcinoma	Genistein (NPC39426)	NP level
NCT00584532	Effects of a Genistein Concentrated Polysaccharide (GCP) for Prostate Cancer on Active Surveillance.	prostate cancer	Genistein (NPC39426)	NP level
NCT00541710	Effect of Genistein in Women With Metabolic Syndrome	metabolic syndrome	Genistein (NPC39426)	NP level
NCT00290758	Genistein in Preventing Breast Cancer in Women at High Risk for Breast Cancer	breast cancer	Genistein (NPC39426)	NP level
NCT00244933	Gemcitabine Hydrochloride and Genistein in Treating Women With Stage IV Breast Cancer	breast cancer	Genistein (NPC39426)	NP level
NCT00058266	Genistein in Treating Patients With Localized Prostate Cancer Who Are Planning to Undergo Radical Prostatectomy	prostate cancer	Genistein (NPC39426)	NP level
NCT04482595	BIO 300 Oral Suspension in Previously Hospitalized Long COVID Patients	pulmonary fibrosis;severe acute respiratory syndrome	Genistein (NPC39426)	NP level
NCT00590538	Phenylbutyrate/Genistein Duotherapy in Delta F508-Heterozygotes (for Cystic Fibrosis)	cystic fibrosis	Genistein (NPC39426)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Prostate cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82	AOX1,ESR2,ESR1,MAOB NCT00005827,NCT02766478,NCT00058266,NCT00584532
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	AOX1,MAOB,ESR2,BLM,TSHR,EGFR
Breast cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C60-2C6Y	ESR2,ESR1,EGFR NCT00290758,NCT00244933
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	EGFR,ESRRA,ESR1,ESRRB,AOX1
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	MAOB,ALDH2,BLM,DPP4,CYP2C9
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	MAPT,ALDH2,ESRRB,DPP4,CYP2C9
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	ESRRB,TSHR,DPP4,ESRRA
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	ESRRB,TSHR,ESR1,ESRRA
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	TSHR,BLM,AOX1,DPP4
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	BLM,DPP4,CYP2C9,ESRRA
Carpal tunnel syndrome Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C10.0	AOX1,ESRRB,DPP4,ESR1
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	MAOB,ESR2,MAPT
Non-small cell lung cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25	EGFR NCT02567799,NCT01628471
Vasomotor/allergic rhinitis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA08	ESR2,ESRRA,ESRRB
Psoriasis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA90	DPP4,ESRRA,ESRRB
Metabolic disorder Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C50-5D2Z	DPP4 NCT01664650,NCT00541710
Adenocarcinoma of prostate Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82.0	NCT00546039,NCT01325311,NCT01126879
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	MAPT,ESR2,BLM
Leishmaniasis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F54	TSHR,BLM,DPP4
Squamous cell carcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.2	BLM,TSHR,CYP2C9
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	AOX1,DPP4,EGFR
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	BLM,MAPT,MAPT
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	ESR2,ESRRB,CYP2C9
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	TSHR,BLM,CYP2C9
Malignant neoplasms of corpus uteri, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.Z	ESRRB,BLM,CYP2C9
Asthma Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA23	ESRRB,ESRRA
Contact dermatitis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EK00-EK0Z	ESRRB,ESRRA
Menopausal disorder Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA30	ESR1,ESR2
Skin disease Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA00-EM0Z	ESRRB,ESRRA
Eyelid inflammatory disorder Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9A02	ESRRA,ESRRB
Colorectal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B91	EGFR NCT01985763
Hepatitis virus infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1E50-1E51	EGFR,ESR2
Atopic eczema Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA80	ESRRB,ESRRA
Inflammatory arthropathy Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA2Z	ESRRA,ESRRB
Hyper-lipoproteinaemia Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C80	ESR1,ESR2
Diabetes mellitus, type unspecified Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A14	DPP4,ESR1
Brain cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00	EGFR,ESR1
Parkinsonism Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A00	MAOB,MAPT
Postoperative inflammation Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1A00-CA43	ESRRA,ESRRB
Malignant neoplasm of pancreas, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.Z	NCT00376948,NCT00882765
Cystic fibrosis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA25	NCT00016744,NCT00590538
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	MAPT,BLM
Myelodysplastic syndromes, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A3Z	TSHR,CYP2C9
Other specified malignant neoplasms of kidney, except renal pelvis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90.Y	CYP2C9,TSHR
Superficial ovarian endometriosis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA10.B4	ESRRB,DPP4
Urothelial carcinoma of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94.2	BLM,CYP2C9
Chikungunya virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D40	ESRRB,EGFR
Invasive carcinoma of breast Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C61	BLM,ESR1
Malignant neoplasms of adrenal gland Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	BLM,DPP4
Vaginitis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA02	ESR1
Type 2 diabetes mellitus Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A11	DPP4
Prostate hyperplasia Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA90	ESR2
Malignant mesenchymal neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B5D-2B5Y	EGFR
Mature T-cell lymphoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A90	EGFR
Bacterial infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1A00-1C4Z	CYP2C9
Hypo-thyroidism Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A00	TSHR
Low bone mass disorder Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FB83	ESR1
Cerebral ischaemia Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B1Z	ALDH2
Mature B-cell leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A82	EGFR
Malaria Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F40-1F45	MAOB
Dyspareunia Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA12	ESR1
Skeletal anomaly Disease Category: 20.Developmental anomalies Disease ICD-11 Code: LD24	ESR1
Urethral cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C93	EGFR
Autism spectrum disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A02	DPP4
Hypopharyngeal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B6D	EGFR
Myocardial infarction Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA41-BA43	DPP4
Rheumatoid arthritis Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA20	ESRRA
Acute diabete complication Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A2Y	DPP4
Metastatic biliary tract neoplasms Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C14-2C17	EGFR
Malignant haematopoietic neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B33	DPP4
Melanoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C30	EGFR
Angina pectoris Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA40	EGFR
Liver cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12	EGFR
Degenerative high myopia Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9B76	ESRRA
Primary psychotic disorder manifestation Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A25	MAOB
Chronic pain Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG30	EGFR
Thyroid cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D10	TSHR
Pancreatic cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10	EGFR
Myelodysplastic syndrome Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A37	EGFR
Stomach cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72	EGFR
Adrenal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	ESR1
Pituitary gland disorder Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A60-5A61	ESR1
Pulmonary hypertension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BB01	MAOB
Acquired hypomelanotic disorder Disease Category: 14.Diseases of the skin Disease ICD-11 Code: ED63	MAOB
Unspecified viral infection of unspecified site Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D9Z	ESR1
Depression Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A70-6A7Z	MAOB
Choreiform disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A01	MAPT
Indeterminate colitis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD72	ESR2
Skin cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C30-2C37	MAOB
Vitamin deficiency Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5B55-5B5F	AOX1
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	MAPT
Migraine Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A80	MAOB
Female pelvic pain Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA34	ESR1
Menstrual cycle bleeding disorder Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA20	ESR1
Testicular cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80	EGFR
Diabetic foot ulcer Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD54	EGFR
Colon cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B90	EGFR
Lung cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25	EGFR
Substance abuse Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6C40	ALDH2
Renal cell carcinoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90	EGFR
Spinal cord/cranial nerve neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A02	EGFR
Muscular dystrophy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C70	MAOB
Skin tag/polyp Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EK71	MAOB
Nausea/vomiting Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MD90	MAOB
Cardiovascular disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA00-BE2Z	ALDH2
Schizophrenia Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A20	ESRRA
General pain disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8E43	MAOB
Female infertility Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA31	ESR1
Breast in situ carcinoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2E65	ESR1
Female genital tract noninflammatory disorder Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA1Y	ESR1
Unspecific body region injury Disease Category: 22.Injury, poisoning or certain other consequences of external causes Disease ICD-11 Code: ND56	EGFR
Acne vulgaris Disease Category: 14.Diseases of the skin Disease ICD-11 Code: ED80	ESR1
Male infertility Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GB04	ESR1
Nasopharyngeal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B6B	EGFR
Acquired prion disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8E01	ESR1
Chronic arterial occlusive disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD4Z	DPP4
Mild neurocognitive disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6D71	MAPT
Sepsis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1G40-1G41	ESR2
Skin postprocedural disorder Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EL8Y	EGFR
Dementia Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6D80-6D8Z	MAOB
Unspecific substance use disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6C4Z	ALDH2
Intracerebral haemorrhage Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B00	EGFR
Head and neck cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D42	EGFR
Metastatic tumour Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D50-2E2Z	ESR1
Metastatic lymph node neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D60	EGFR
Cushing syndrome Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A70	ESR2
Endometriosis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA10	ESR1
Multiple sclerosis Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A40	ESR1
Ischemia Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B10-8B11	EGFR
Malignant neoplasms of bladder, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94.Z	NCT01489813
Unspecified malignant neoplasms of unspecified sites Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D4Z	NCT00001696
Neoplasms of unknown behaviour of urinary organs Disease Category: 02.Neoplasms Disease ICD-11 Code: 2F98	NCT00118040
Malignant neoplasms of colon Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B90	NCT01985763
Rectum cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B92	NCT01985763
Idiopathic pulmonary fibrosis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CB03.4	NCT04482595
Severe acute respiratory syndrome Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D65	NCT04482595
Osteoporosis Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FB83.1	NCT00010686
coronary artery disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA8Y-BA8Z	NCT00287690
Coeliac disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DA95	TSHR
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	BLM
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	BLM
West Nile virus infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D46	DPP4
Tetralogy of Fallot Disease Category: 20.Developmental anomalies Disease ICD-11 Code: LA88.2	ESRRB
Pneumonia due to Pseudomonasaeruginosa Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA40.05	DPP4
Malignant neoplasms of oesophagus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B70	BLM
Systemic lupus erythematosus Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A40.0	ESRRB
Malignant neoplasms of thyroid gland, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D10.Z	DPP4
Renal cell carcinoma, chromophobe type Disease Category: X.Extension Codes Disease ICD-11 Code: XH6153	ESRRA
Gliomas of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.0	BLM

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Astragalus Bicuspis

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

12 All known Ingredients in Total

5 Ingredients with Acceptable Bioavailablity

9 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Prostate cancer

Diffuse large B-cell lymphomas

Breast cancer

Solid tumour/cancer

Adenocarcinoma of pancreas

Malignant neoplasms of thymus

Carcinosarcoma of uterus

Serous cystadenoma,borderline malignancy of ovary

Glioblastoma of brain

Germ cell tumour of testis

Carpal tunnel syndrome

Alzheimer disease

Non-small cell lung cancer

Vasomotor/allergic rhinitis

Psoriasis

Metabolic disorder

Adenocarcinoma of prostate

Malignant neoplasms of biliary tract, distal bile duct

Leishmaniasis

Squamous cell carcinoma of bronchus or lung

Mesothelioma of pleura

Hepatocellular carcinoma of liver

Cytomegaloviral disease

Adenocarcinoma of bronchus or lung

Malignant neoplasms of corpus uteri, unspecified

Asthma

Contact dermatitis

Menopausal disorder

Skin disease

Eyelid inflammatory disorder

Colorectal cancer

Hepatitis virus infection

Atopic eczema

Inflammatory arthropathy

Hyper-lipoproteinaemia

Diabetes mellitus, type unspecified

Brain cancer

Parkinsonism

Postoperative inflammation

Malignant neoplasm of pancreas, unspecified

Cystic fibrosis

Pheochromocytoma

Myelodysplastic syndromes, unspecified

Other specified malignant neoplasms of kidney, except renal pelvis

Superficial ovarian endometriosis

Urothelial carcinoma of bladder

Chikungunya virus disease

Invasive carcinoma of breast

Malignant neoplasms of adrenal gland

Vaginitis

Type 2 diabetes mellitus

Prostate hyperplasia

Malignant mesenchymal neoplasm

Mature T-cell lymphoma

Bacterial infection

Hypo-thyroidism

Low bone mass disorder

Cerebral ischaemia

Mature B-cell leukaemia

Malaria

Dyspareunia

Skeletal anomaly

Urethral cancer

Autism spectrum disorder