Plant ID: NPO12730
Plant Latin Name: Heracleum Maximum
Taxonomy Genus: Heracleum
Taxonomy Family: Apiaceae
NCBI TaxonomyDB:
40918
Plant-of-the-World-Online:
n.a.
India
Ingredient ID: NPC96780
Ingredient ID: NPC96259
Ingredient ID: NPC95472
Ingredient ID: NPC94212
Ingredient ID: NPC91391
Ingredient ID: NPC88445
Ingredient ID: NPC84695
Ingredient ID: NPC79067
Ingredient ID: NPC78612
Ingredient ID: NPC74539
Ingredient ID: NPC68819
Ingredient ID: NPC64957
Ingredient ID: NPC62763
Ingredient ID: NPC60175
Ingredient ID: NPC56153
Ingredient ID: NPC51146
Ingredient ID: NPC50669
Ingredient ID: NPC39656
Ingredient ID: NPC312665
Ingredient ID: NPC310040
Ingredient ID: NPC305937
Ingredient ID: NPC304443
Ingredient ID: NPC303864
Ingredient ID: NPC303477
Ingredient ID: NPC301373
Ingredient ID: NPC292753
Ingredient ID: NPC286540
Ingredient ID: NPC281344
Ingredient ID: NPC277907
Ingredient ID: NPC277781
Ingredient ID: NPC26417
Ingredient ID: NPC262345
Ingredient ID: NPC25504
Ingredient ID: NPC247867
Ingredient ID: NPC245798
Ingredient ID: NPC245311
Ingredient ID: NPC239180
Ingredient ID: NPC23622
Ingredient ID: NPC235586
Ingredient ID: NPC234536
Ingredient ID: NPC233418
Ingredient ID: NPC229756
Ingredient ID: NPC225870
Ingredient ID: NPC224686
Ingredient ID: NPC223811
Ingredient ID: NPC214614
Ingredient ID: NPC213192
Ingredient ID: NPC20525
Ingredient ID: NPC202944
Ingredient ID: NPC198816
Ingredient ID: NPC191519
Ingredient ID: NPC191476
Ingredient ID: NPC191161
Ingredient ID: NPC190749
Ingredient ID: NPC181051
Ingredient ID: NPC179464
Ingredient ID: NPC17828
Ingredient ID: NPC174010
Ingredient ID: NPC169
Ingredient ID: NPC167611
Ingredient ID: NPC157192
Ingredient ID: NPC147795
Ingredient ID: NPC145379
Ingredient ID: NPC127265
Ingredient ID: NPC12380
Ingredient ID: NPC122862
Ingredient ID: NPC121824
Ingredient ID: NPC120926
Ingredient ID: NPC114979
Ingredient ID: NPC112428
Ingredient ID: NPC110686
Ingredient ID: NPC108347
Ingredient ID: NPC101751
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
Cytochrome P450 | Cytochrome P450 family 2 | CYP2A6 | Cytochrome P450 2A6 | P11509 | CHEMBL5282 |
Therapeutic Target | Other cytosolic protein | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 2 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00005092 | Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer | leukemia;multiple myeloma;myelodysplastic syndrome | Psoralen (NPC51146) | NP level |
NCT00533195 | Comparison of UVA1 Phototherapy Versus Photochemotherapy for Patients With Severe Generalized Atopic Dermatitis | atopic eczema | Bergapten (NPC74539) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
MAPT,MAPT
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CYP1A2,CYP1A1
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
MAPT
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
MAPT
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
MAPT
|
Mycosis fungoidesDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B01 |
CYP2A6
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
MAPT
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
MAPT
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
CYP2A6
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
NCT00005092
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
NCT00005092
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
NCT00533195
|
LeukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60-2B33 |
NCT00005092
|
Coeliac diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA95 |
CYP1A1
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
CYP1A2
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
MAPT
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
MAPT
|
Myotonic dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C71.0 |
CYP1A1
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
CYP1A1
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CYP1A2
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
CYP1A1
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
CYP1A1
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
CYP1A1
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
CYP1A1
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
MAPT
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
CYP2A6
|