Plant ID: NPO12468
Plant Latin Name: Asarum Heterotropoides
Taxonomy Genus: Asarum
Taxonomy Family: Aristolochiaceae
NCBI TaxonomyDB:
366663
Plant-of-the-World-Online:
n.a.
Unknown.
Ingredient ID: NPC99886
Ingredient ID: NPC97870
Ingredient ID: NPC97128
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Ingredient ID: NPC190945
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Ingredient ID: NPC180684
Ingredient ID: NPC180466
Ingredient ID: NPC179950
Ingredient ID: NPC178223
Ingredient ID: NPC177112
Ingredient ID: NPC173996
Ingredient ID: NPC171928
Ingredient ID: NPC168855
Ingredient ID: NPC166894
Ingredient ID: NPC166362
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Ingredient ID: NPC164542
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Ingredient ID: NPC13991
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Ingredient ID: NPC131981
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Ingredient ID: NPC129687
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Ingredient ID: NPC127326
Ingredient ID: NPC123526
Ingredient ID: NPC119949
Ingredient ID: NPC119579
Ingredient ID: NPC118284
Ingredient ID: NPC115499
Ingredient ID: NPC114239
Ingredient ID: NPC113101
Ingredient ID: NPC111544
Ingredient ID: NPC105509
Ingredient ID: NPC101153
Ingredient ID: NPC100223
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
Drug Transporter | Voltage-gated calcium channel | CACNA1C | Voltage-gated L-type calcium channel alpha-1C subunit | Q13936 | CHEMBL1940 |
Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Therapeutic Target | Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
![]() | 432 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00000102 | Congenital Adrenal Hyperplasia: Calcium Channels as Therapeutic Targets | congenital adrenal hyperplasia | Nifedipine (NPC190945) | ![]() |
NCT00000478 | Asymptomatic Cardiac Ischemia Pilot (ACIP) Study | Myocardial Ischemia | Nifedipine (NPC190945);Atenolol (NPC307123) | ![]() |
NCT00000513 | Trial of Antihypertensive Intervention Management | heart disease;hypertension | Atenolol (NPC307123) | ![]() |
NCT00000514 | Systolic Hypertension in the Elderly Program (SHEP) | cerebrovascular disorder;heart disease;hypertension | Atenolol (NPC307123) | ![]() |
NCT00000530 | Raynaud's Treatment Study (RTS) | Raynaud disease | Nifedipine (NPC190945) | ![]() |
NCT00004266 | Drugs for High Blood Pressure and High Cholesterol in American Indians With Type 2 Diabetes | diabetic nephropathy | Nifedipine (NPC190945) | ![]() |
NCT00005806 | Combination Chemotherapy in Treating Patients With Advanced Non-Small Cell Lung Cancer | lung cancer | Gefitinib (NPC56271) | ![]() |
NCT00006048 | ZD 1839 Plus Combination Chemotherapy in Treating Patients With Non-Small Cell Lung Cancer | lung cancer | Gefitinib (NPC56271) | ![]() |
NCT00006049 | ZD 1839 Plus Chemotherapy in Treating Patients With Non-Small Cell Lung Cancer | lung cancer | Gefitinib (NPC56271) | ![]() |
NCT00012337 | ZD 1839 in Treating Patients With Metastatic Kidney Cancer | kidney cancer | Gefitinib (NPC56271) | ![]() |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKB,ADRB1,DPP4,KDR
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
MAPT,AXL,ERBB4,KDM1A,RELA,PIM1,SRC,TP53,AURKB,FLT3,NFKB1
NCT00130702 |
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1,RELA
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,NPSR1,BLM,TSHR,AURKB,XDH,PTK6,CDK1,CHEK2,CA7
NCT00344773 |
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CACNA1C,BLM,CA2,LCK,ALOX15,CHEK2,CA7,ABCG2,AURKB,HCK,XDH,POLB,CCR2,RECQL,DPP4,ERBB2,PIM1,LMNA,CES1,LYN,BLK,RIPK2,CYP1B1,ADRA1B,ALOX5,DRD1,HIF1A,PTK6,MET,AXL,NPSR1
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
NOX4,ALOX15
NCT01912820 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
NPSR1,NOX4,BLM,CDK1,DRD1,CYP19A1,ALOX15,MET,AURKB
|
AdenocarcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D40 |
NCT03486496,NCT02951637,NCT00020709,NCT00049543,NCT00040794,NCT00198380
|
Adrenomedullary hyperfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A75 |
HIF1A
|