Collective Molecular Activities of the Plant: Chenopodium Quinoa
Unknown.
Peru; Argentina; Bolivia; Ecuador; Chile
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
96 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
81 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
57 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC94167
Ingredient ID: NPC93888
Ingredient ID: NPC88255
Ingredient ID: NPC85813
Ingredient ID: NPC84585
Ingredient ID: NPC72184
Ingredient ID: NPC68224
Ingredient ID: NPC65196
Ingredient ID: NPC63599
Ingredient ID: NPC62045
Ingredient ID: NPC61473
Ingredient ID: NPC60825
Ingredient ID: NPC59650
Ingredient ID: NPC56386
Ingredient ID: NPC55412
Ingredient ID: NPC53069
Ingredient ID: NPC51174
Ingredient ID: NPC51129
Ingredient ID: NPC489908
Ingredient ID: NPC489907
Ingredient ID: NPC489899
Ingredient ID: NPC48623
Ingredient ID: NPC328447
Ingredient ID: NPC317120
Ingredient ID: NPC308771
Ingredient ID: NPC305712
Ingredient ID: NPC295644
Ingredient ID: NPC294902
Ingredient ID: NPC294548
Ingredient ID: NPC293933
Ingredient ID: NPC291419
Ingredient ID: NPC289795
Ingredient ID: NPC284475
Ingredient ID: NPC281686
Ingredient ID: NPC281517
Ingredient ID: NPC279292
Ingredient ID: NPC273103
Ingredient ID: NPC272614
Ingredient ID: NPC270796
Ingredient ID: NPC269919
Ingredient ID: NPC2660
Ingredient ID: NPC261831
Ingredient ID: NPC260491
Ingredient ID: NPC242580
Ingredient ID: NPC239128
Ingredient ID: NPC237812
Ingredient ID: NPC22675
Ingredient ID: NPC226453
Ingredient ID: NPC224526
Ingredient ID: NPC223263
Ingredient ID: NPC216630
Ingredient ID: NPC212794
Ingredient ID: NPC212452
Ingredient ID: NPC211203
Ingredient ID: NPC210148
Ingredient ID: NPC208793
Ingredient ID: NPC208104
Ingredient ID: NPC20791
Ingredient ID: NPC206155
Ingredient ID: NPC203468
Ingredient ID: NPC202009
Ingredient ID: NPC197459
Ingredient ID: NPC192768
Ingredient ID: NPC190298
Ingredient ID: NPC189960
Ingredient ID: NPC185755
Ingredient ID: NPC185467
Ingredient ID: NPC179400
Ingredient ID: NPC179007
Ingredient ID: NPC17810
Ingredient ID: NPC176482
Ingredient ID: NPC174246
Ingredient ID: NPC167400
Ingredient ID: NPC165693
Ingredient ID: NPC165395
Ingredient ID: NPC159823
Ingredient ID: NPC159082
Ingredient ID: NPC15848
Ingredient ID: NPC152451
Ingredient ID: NPC150950
Ingredient ID: NPC150648
Ingredient ID: NPC147983
Ingredient ID: NPC142165
Ingredient ID: NPC137958
Ingredient ID: NPC137074
Ingredient ID: NPC136994
Ingredient ID: NPC136014
Ingredient ID: NPC126681
Ingredient ID: NPC123965
Ingredient ID: NPC122172
Ingredient ID: NPC119158
Ingredient ID: NPC116775
Ingredient ID: NPC11433
Ingredient ID: NPC112890
Ingredient ID: NPC111485
Ingredient ID: NPC103904
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 463 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000114 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000116 | Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
| NCT00000372 | Glycine and D-Cycloserine in Schizophrenia | schizophrenia | Glycine (NPC126681) | NP level |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction | Folic Acid (NPC147983);Pyridoxine (NPC269919);Beta Carotene (NPC17810) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
NCT00694564
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
NCT03090048 |
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKB,KDR,FFAR1,PPARA,DPP4
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1,TP53,AXL,AURKB,SRC,FLT3,PIM1
NCT01842139 |
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT02929888
|
Acute viral hepatitisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E50 |
NCT00108589
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
