Plant ID: NPO12265
Plant Latin Name: Aquilaria Agallochum
Taxonomy Genus: Aquilaria
Taxonomy Family: Thymelaeaceae
NCBI TaxonomyDB:
1472648
Plant-of-the-World-Online:
n.a.
India
Ingredient ID: NPC98049
Ingredient ID: NPC96624
Ingredient ID: NPC96218
Ingredient ID: NPC94209
Ingredient ID: NPC93297
Ingredient ID: NPC90566
Ingredient ID: NPC9029
Ingredient ID: NPC90232
Ingredient ID: NPC84677
Ingredient ID: NPC82042
Ingredient ID: NPC80188
Ingredient ID: NPC7491
Ingredient ID: NPC74458
Ingredient ID: NPC72181
Ingredient ID: NPC71811
Ingredient ID: NPC66577
Ingredient ID: NPC60036
Ingredient ID: NPC59907
Ingredient ID: NPC54879
Ingredient ID: NPC54732
Ingredient ID: NPC54487
Ingredient ID: NPC45107
Ingredient ID: NPC42724
Ingredient ID: NPC424
Ingredient ID: NPC41655
Ingredient ID: NPC39077
Ingredient ID: NPC39068
Ingredient ID: NPC38790
Ingredient ID: NPC36061
Ingredient ID: NPC34440
Ingredient ID: NPC33179
Ingredient ID: NPC308749
Ingredient ID: NPC307216
Ingredient ID: NPC307215
Ingredient ID: NPC306120
Ingredient ID: NPC305296
Ingredient ID: NPC30430
Ingredient ID: NPC301964
Ingredient ID: NPC301585
Ingredient ID: NPC301295
Ingredient ID: NPC300723
Ingredient ID: NPC298224
Ingredient ID: NPC297358
Ingredient ID: NPC296929
Ingredient ID: NPC287165
Ingredient ID: NPC286570
Ingredient ID: NPC284034
Ingredient ID: NPC280884
Ingredient ID: NPC279936
Ingredient ID: NPC279404
Ingredient ID: NPC279026
Ingredient ID: NPC278683
Ingredient ID: NPC278613
Ingredient ID: NPC278525
Ingredient ID: NPC275050
Ingredient ID: NPC27226
Ingredient ID: NPC267812
Ingredient ID: NPC266093
Ingredient ID: NPC266061
Ingredient ID: NPC261831
Ingredient ID: NPC261080
Ingredient ID: NPC260731
Ingredient ID: NPC256551
Ingredient ID: NPC256179
Ingredient ID: NPC255136
Ingredient ID: NPC253204
Ingredient ID: NPC251857
Ingredient ID: NPC249891
Ingredient ID: NPC249632
Ingredient ID: NPC246543
Ingredient ID: NPC246080
Ingredient ID: NPC244300
Ingredient ID: NPC243047
Ingredient ID: NPC242585
Ingredient ID: NPC241110
Ingredient ID: NPC23851
Ingredient ID: NPC236579
Ingredient ID: NPC23552
Ingredient ID: NPC235251
Ingredient ID: NPC234827
Ingredient ID: NPC234231
Ingredient ID: NPC232957
Ingredient ID: NPC230329
Ingredient ID: NPC229403
Ingredient ID: NPC223455
Ingredient ID: NPC222658
Ingredient ID: NPC21854
Ingredient ID: NPC217191
Ingredient ID: NPC216630
Ingredient ID: NPC216127
Ingredient ID: NPC214067
Ingredient ID: NPC213842
Ingredient ID: NPC211762
Ingredient ID: NPC210354
Ingredient ID: NPC207844
Ingredient ID: NPC205727
Ingredient ID: NPC203719
Ingredient ID: NPC203286
Ingredient ID: NPC196924
Ingredient ID: NPC194554
Ingredient ID: NPC194526
Ingredient ID: NPC193036
Ingredient ID: NPC192962
Ingredient ID: NPC187234
Ingredient ID: NPC185189
Ingredient ID: NPC183999
Ingredient ID: NPC183067
Ingredient ID: NPC180730
Ingredient ID: NPC179024
Ingredient ID: NPC176589
Ingredient ID: NPC173403
Ingredient ID: NPC173036
Ingredient ID: NPC171294
Ingredient ID: NPC161640
Ingredient ID: NPC16157
Ingredient ID: NPC154186
Ingredient ID: NPC153053
Ingredient ID: NPC150021
Ingredient ID: NPC146197
Ingredient ID: NPC142900
Ingredient ID: NPC13789
Ingredient ID: NPC135648
Ingredient ID: NPC135388
Ingredient ID: NPC131579
Ingredient ID: NPC129489
Ingredient ID: NPC129144
Ingredient ID: NPC128575
Ingredient ID: NPC125737
Ingredient ID: NPC115879
Ingredient ID: NPC114764
Ingredient ID: NPC113243
Ingredient ID: NPC113184
Ingredient ID: NPC112619
Ingredient ID: NPC106250
Ingredient ID: NPC104569
Ingredient ID: NPC10251
Ingredient ID: NPC101285
Ingredient ID: NPC10068
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
Therapeutic Target | Fatty acid binding protein family | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Therapeutic Target | Nuclear hormone receptor subfamily 1 | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 3 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT01661764 | Fish Oil Supplementation, Nutrigenomics and Colorectal Cancer Prevention | colorectal adenoma | Oleic Acid (NPC261831) | NP level |
NCT01792310 | A Phase 1/2A Study of LAM561 in Adult Patients With Advanced Solid Tumours | glioma | Oleic Acid (NPC261831) | NP level |
NCT00638196 | Placebo vs. Linoleic Acid Controlled Assessment of Treatment Efficacy in MS | multiple sclerosis | Oleic Acid (NPC261831) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
TRIM24,PPARA,FABP4,OR51E2,FABP5
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
FABP5,TRIM24,FABP4,OR51E2
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
FABP5,FABP4,OR51E2,TRIM24
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
FABP5,FABP5,OR51E2
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
TRIM24,CYP3A4,FABP5
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
FABP5,CYP3A4,OR51E2
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
CYP3A4,PPARA
|
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
PPARA
FABP4 |
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
FABP5,OR51E2
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
FABP5,OR51E2
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
FABP5,OR51E2
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
PPARA
|
GoutDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA25 |
PPARA
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
PPARA
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
CYP3A4
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
PPARA
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
PPARA
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CYP3A4
|
Inborn lipid metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52 |
PPARA
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
PPARA
|
DyslipidemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80-5C81 |
PPARA
|
HyperlipidemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
PPARA
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
NCT00638196
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
NCT01661764
|
Glioma, malignantDisease Category: X.Extension CodesDisease ICD-11 Code: XH4RQ3 |
NCT01792310
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
FABP5
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
FABP5
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
FABP5
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
FABP4
|
Malignant neoplasms of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
FABP4
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
OR51E2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
OR51E2
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
OR51E2
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CYP3A4
|
Systemic sclerosisDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A42 |
FABP4
|
Malignant neoplasms of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
FABP4
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
FABP5
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CYP3A4
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
FABP5
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
OR51E2
|
Malignant neoplasm of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
FABP4
|