Collective Molecular Activities of the Plant: Dendrobium Chrysanthum
Country/Region:
China; IndiaTraditional Medicine System:
Indian Folk; TCMMyanmar; Nepal; India; Vietnam; China; Laos; Thailand
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
98 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
85 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
63 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC95995
Ingredient ID: NPC90803
Ingredient ID: NPC88566
Ingredient ID: NPC84807
Ingredient ID: NPC82648
Ingredient ID: NPC80471
Ingredient ID: NPC80370
Ingredient ID: NPC79943
Ingredient ID: NPC78500
Ingredient ID: NPC72258
Ingredient ID: NPC7163
Ingredient ID: NPC70970
Ingredient ID: NPC66681
Ingredient ID: NPC66027
Ingredient ID: NPC64176
Ingredient ID: NPC61198
Ingredient ID: NPC57490
Ingredient ID: NPC52403
Ingredient ID: NPC49151
Ingredient ID: NPC47422
Ingredient ID: NPC43246
Ingredient ID: NPC42471
Ingredient ID: NPC41476
Ingredient ID: NPC38017
Ingredient ID: NPC34103
Ingredient ID: NPC33761
Ingredient ID: NPC32441
Ingredient ID: NPC312929
Ingredient ID: NPC311485
Ingredient ID: NPC30506
Ingredient ID: NPC298757
Ingredient ID: NPC298346
Ingredient ID: NPC292828
Ingredient ID: NPC290613
Ingredient ID: NPC29
Ingredient ID: NPC288089
Ingredient ID: NPC287272
Ingredient ID: NPC285776
Ingredient ID: NPC285554
Ingredient ID: NPC279300
Ingredient ID: NPC275462
Ingredient ID: NPC265863
Ingredient ID: NPC262505
Ingredient ID: NPC26229
Ingredient ID: NPC25513
Ingredient ID: NPC245898
Ingredient ID: NPC243759
Ingredient ID: NPC243728
Ingredient ID: NPC2426
Ingredient ID: NPC241721
Ingredient ID: NPC240722
Ingredient ID: NPC239996
Ingredient ID: NPC239406
Ingredient ID: NPC232375
Ingredient ID: NPC23145
Ingredient ID: NPC230919
Ingredient ID: NPC230301
Ingredient ID: NPC230221
Ingredient ID: NPC217867
Ingredient ID: NPC216630
Ingredient ID: NPC213935
Ingredient ID: NPC212832
Ingredient ID: NPC21180
Ingredient ID: NPC204353
Ingredient ID: NPC196924
Ingredient ID: NPC196021
Ingredient ID: NPC194458
Ingredient ID: NPC193544
Ingredient ID: NPC190810
Ingredient ID: NPC190245
Ingredient ID: NPC186268
Ingredient ID: NPC177112
Ingredient ID: NPC171351
Ingredient ID: NPC16728
Ingredient ID: NPC165159
Ingredient ID: NPC164135
Ingredient ID: NPC163556
Ingredient ID: NPC156655
Ingredient ID: NPC156654
Ingredient ID: NPC156461
Ingredient ID: NPC154275
Ingredient ID: NPC153572
Ingredient ID: NPC151242
Ingredient ID: NPC149621
Ingredient ID: NPC149337
Ingredient ID: NPC142753
Ingredient ID: NPC142588
Ingredient ID: NPC141986
Ingredient ID: NPC141765
Ingredient ID: NPC130683
Ingredient ID: NPC128280
Ingredient ID: NPC115835
Ingredient ID: NPC111888
Ingredient ID: NPC110899
Ingredient ID: NPC110373
Ingredient ID: NPC109192
Ingredient ID: NPC107482
Ingredient ID: NPC10251
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Therapeutic Target | Hydrolase | CDA | Cytidine deaminase | P32320 | CHEMBL4502 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Therapeutic Target | Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Therapeutic Target | Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Therapeutic Target | Phosphodiesterase | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 53 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00001986 | 1-Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00016679 | 1-Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00080366 | Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00102596 | Clinical Trial Characterizing the Bioavailability of 1-Octanol in Adults With Ethanol-responsive Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00179010 | AMP as a Better Delivery System of Adenosine | ischemia | Adenosine (NPC156461) | NP level |
| NCT00210080 | A Study to Diagnose Lung Cancer by Sputum Cytology (01-312) | lung cancer | Uridine (NPC43246) | NP level |
| NCT00218946 | Nasogastric Tube in Premature Babies - Pain and Treatment | premature birth | Sucrose (NPC130683) | NP level |
| NCT00284323 | Salvage: Postconditioning With Adenosine for STEMI | ST Elevation Myocardial Infarction | Adenosine (NPC156461) | NP level |
| NCT00298636 | Dose-Response of Adenosine for Perioperative Pain | pain | Adenosine (NPC156461) | NP level |
| NCT00322764 | Phase II Study to Assess RG2417 in the Treatment of Bipolar I Depression | bipolar disorder | Uridine (NPC43246) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
DPP4
|
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT00781404
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT03718507,NCT04588441
|
Acute ST elevation myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41.0 |
NCT01747174,NCT00284323
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,CDA,TSHR,F2,CA7
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
DPP4,CA14,ADORA2A,CA2,F2,CA7,OR51E2,ADORA3
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
FABP5,OR51E2
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2,CYP19A1
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
NCT00751491,NCT01123525 |
AsphyxiaDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD11.1 |
NCT01871142
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
