Collective Molecular Activities of the Plant: Eleutherococcus Senticosus
Country/Region:
RussiaTraditional Medicine System:
Medicinal Functions:
Adaptogen; Antiinflammatory; Hypoglycaemic; Tonic; Vasodilator
Japan; China; Russia; South Africa
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
141 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
75 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
64 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99480
Ingredient ID: NPC95392
Ingredient ID: NPC93201
Ingredient ID: NPC93033
Ingredient ID: NPC90725
Ingredient ID: NPC87466
Ingredient ID: NPC85813
Ingredient ID: NPC84398
Ingredient ID: NPC83798
Ingredient ID: NPC83535
Ingredient ID: NPC81010
Ingredient ID: NPC78612
Ingredient ID: NPC78479
Ingredient ID: NPC76972
Ingredient ID: NPC70744
Ingredient ID: NPC67857
Ingredient ID: NPC66700
Ingredient ID: NPC5982
Ingredient ID: NPC59474
Ingredient ID: NPC55830
Ingredient ID: NPC55715
Ingredient ID: NPC55063
Ingredient ID: NPC54395
Ingredient ID: NPC5326
Ingredient ID: NPC52230
Ingredient ID: NPC52086
Ingredient ID: NPC49074
Ingredient ID: NPC488688
Ingredient ID: NPC488687
Ingredient ID: NPC488686
Ingredient ID: NPC488685
Ingredient ID: NPC488684
Ingredient ID: NPC488683
Ingredient ID: NPC488682
Ingredient ID: NPC35877
Ingredient ID: NPC35519
Ingredient ID: NPC34902
Ingredient ID: NPC34103
Ingredient ID: NPC33611
Ingredient ID: NPC33320
Ingredient ID: NPC32977
Ingredient ID: NPC314434
Ingredient ID: NPC309907
Ingredient ID: NPC306470
Ingredient ID: NPC306195
Ingredient ID: NPC304964
Ingredient ID: NPC302857
Ingredient ID: NPC29883
Ingredient ID: NPC294902
Ingredient ID: NPC293377
Ingredient ID: NPC293305
Ingredient ID: NPC290319
Ingredient ID: NPC28913
Ingredient ID: NPC288254
Ingredient ID: NPC279633
Ingredient ID: NPC279610
Ingredient ID: NPC279481
Ingredient ID: NPC278124
Ingredient ID: NPC277493
Ingredient ID: NPC27730
Ingredient ID: NPC275769
Ingredient ID: NPC273730
Ingredient ID: NPC272801
Ingredient ID: NPC272195
Ingredient ID: NPC271087
Ingredient ID: NPC27075
Ingredient ID: NPC268221
Ingredient ID: NPC267635
Ingredient ID: NPC266061
Ingredient ID: NPC264711
Ingredient ID: NPC253905
Ingredient ID: NPC249045
Ingredient ID: NPC247871
Ingredient ID: NPC24747
Ingredient ID: NPC243509
Ingredient ID: NPC242580
Ingredient ID: NPC236579
Ingredient ID: NPC234536
Ingredient ID: NPC230301
Ingredient ID: NPC229230
Ingredient ID: NPC227058
Ingredient ID: NPC223697
Ingredient ID: NPC220089
Ingredient ID: NPC216630
Ingredient ID: NPC214458
Ingredient ID: NPC214374
Ingredient ID: NPC210460
Ingredient ID: NPC209970
Ingredient ID: NPC205380
Ingredient ID: NPC204673
Ingredient ID: NPC19834
Ingredient ID: NPC196924
Ingredient ID: NPC19530
Ingredient ID: NPC194857
Ingredient ID: NPC192107
Ingredient ID: NPC184049
Ingredient ID: NPC178134
Ingredient ID: NPC177002
Ingredient ID: NPC174720
Ingredient ID: NPC17252
Ingredient ID: NPC171928
Ingredient ID: NPC171736
Ingredient ID: NPC16830
Ingredient ID: NPC167976
Ingredient ID: NPC165204
Ingredient ID: NPC165159
Ingredient ID: NPC164700
Ingredient ID: NPC162534
Ingredient ID: NPC161193
Ingredient ID: NPC157781
Ingredient ID: NPC156654
Ingredient ID: NPC155977
Ingredient ID: NPC155767
Ingredient ID: NPC154186
Ingredient ID: NPC153745
Ingredient ID: NPC153572
Ingredient ID: NPC149203
Ingredient ID: NPC143639
Ingredient ID: NPC142753
Ingredient ID: NPC141765
Ingredient ID: NPC141273
Ingredient ID: NPC138582
Ingredient ID: NPC138347
Ingredient ID: NPC136165
Ingredient ID: NPC1321
Ingredient ID: NPC129489
Ingredient ID: NPC126759
Ingredient ID: NPC125275
Ingredient ID: NPC123965
Ingredient ID: NPC117237
Ingredient ID: NPC117057
Ingredient ID: NPC115776
Ingredient ID: NPC114287
Ingredient ID: NPC111897
Ingredient ID: NPC111888
Ingredient ID: NPC111395
Ingredient ID: NPC110899
Ingredient ID: NPC110528
Ingredient ID: NPC1075
Ingredient ID: NPC107482
Ingredient ID: NPC100223
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2A13 | Cytochrome P450 2A13 | Q16696 | CHEMBL3542436 |
| Drug Transporter | SLC superfamily of solute carriers | SLC22A6 | Solute carrier family 22 member 6 | Q4U2R8 | CHEMBL1641347 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Enzyme | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 38 | |
 Plant level | 1 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00004359 | Phase II Pilot Study of Extracorporeal Phototherapy for Epidermolysis Bullosa Acquisita | epidermolysis bullosa acquisita | Methoxsalen (NPC33320) | NP level |
| NCT00029679 | Borage Oil and Ginkgo Biloba (EGb 761) in Asthma | asthma | Linoleic Acid (NPC85813) | NP level |
| NCT00030589 | Chemotherapy and Photodynamic Therapy in Treating Patients With Cutaneous T-Cell Lymphoma | lymphoma | Methoxsalen (NPC33320) | NP level |
| NCT00054600 | Safety and Efficacy Study of Photopheresis With UVADEX to Prevent Graft-versus-Host Disease | graft versus host disease | Methoxsalen (NPC33320) | NP level |
| NCT00054613 | Safety and Efficacy Study of Photopheresis Plus Standard Therapy to Treat Chronic Graft-versus-Host Disease | graft versus host disease | Methoxsalen (NPC33320) | NP level |
| NCT00056056 | Ultraviolet Light Therapy Using Methoxsalen With or Without Bexarotene in Treating Patients With Mycosis Fungoides | lymphoma | Methoxsalen (NPC33320) | NP level |
| NCT00056355 | Extracorporeal Photopheresis to Maintain Symptoms Remission During Steroid Withdrawal in Patients With Steroid-Dependent Crohn's Disease | Crohn's disease | Methoxsalen (NPC33320) | NP level |
| NCT00204932 | Effects of CLA Supplements on Body Weight and Fat Oxidation | obesity | Linoleic Acid (NPC85813) | NP level |
| NCT00221000 | Safety and Efficacy of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Rheumatoid Arthritis | rheumatoid arthritis | Methoxsalen (NPC33320) | NP level |
| NCT00221026 | Safety and Efficacy of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Crohn's Disease | Crohn's disease | Methoxsalen (NPC33320) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AKR1B1,INSR,KDR,FFAR1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1,SRC
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
MMP1,CYP2C9,MMP9,AKR1C3,TSHR,ACHE,GPR35,F2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
NUAK1,DRD1,ACHE,POLB,TEK,MMP2,LMNA,CA14,OR51E2,MMP1,FFAR4,FABP3,AKR1C3,CA2,F2,CYP1B1,GSTP1,MET,SNCA,CYP2C9,ALOX15,RECQL
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
OR51E2,FABP5,ALOX15
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
MET,MMP1,MMP9,DRD1,ALOX15,F2
|
Allergic/hypersensitivity disorderDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A80-4A8Z |
DRD1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
