Collective Molecular Activities of the Plant: Illicium Difengpi
Plant ID: NPO11871
Plant Latin Name: Illicium Difengpi
Taxonomy Genus: Illicium
Taxonomy Family: Schisandraceae
Plant External Links:
NCBI TaxonomyDB:
124772
Plant-of-the-World-Online:
n.a.
Country/Region:
ChinaTraditional Medicine System:
TCMChina
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
120 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
105 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
68 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC95675
Ingredient ID: NPC93843
Ingredient ID: NPC91574
Ingredient ID: NPC88566
Ingredient ID: NPC82648
Ingredient ID: NPC78551
Ingredient ID: NPC76145
Ingredient ID: NPC75158
Ingredient ID: NPC71853
Ingredient ID: NPC71703
Ingredient ID: NPC71506
Ingredient ID: NPC68889
Ingredient ID: NPC67037
Ingredient ID: NPC63697
Ingredient ID: NPC61769
Ingredient ID: NPC60556
Ingredient ID: NPC60555
Ingredient ID: NPC57877
Ingredient ID: NPC54264
Ingredient ID: NPC5423
Ingredient ID: NPC51189
Ingredient ID: NPC49026
Ingredient ID: NPC469625
Ingredient ID: NPC469622
Ingredient ID: NPC469621
Ingredient ID: NPC469614
Ingredient ID: NPC469613
Ingredient ID: NPC469612
Ingredient ID: NPC45727
Ingredient ID: NPC44751
Ingredient ID: NPC43822
Ingredient ID: NPC43114
Ingredient ID: NPC40249
Ingredient ID: NPC3649
Ingredient ID: NPC36408
Ingredient ID: NPC35932
Ingredient ID: NPC34764
Ingredient ID: NPC31279
Ingredient ID: NPC310905
Ingredient ID: NPC309182
Ingredient ID: NPC301195
Ingredient ID: NPC301043
Ingredient ID: NPC300649
Ingredient ID: NPC30043
Ingredient ID: NPC298080
Ingredient ID: NPC297358
Ingredient ID: NPC292792
Ingredient ID: NPC291100
Ingredient ID: NPC290613
Ingredient ID: NPC290189
Ingredient ID: NPC290078
Ingredient ID: NPC29
Ingredient ID: NPC289366
Ingredient ID: NPC288411
Ingredient ID: NPC287331
Ingredient ID: NPC277728
Ingredient ID: NPC274613
Ingredient ID: NPC270072
Ingredient ID: NPC26906
Ingredient ID: NPC268564
Ingredient ID: NPC264317
Ingredient ID: NPC257124
Ingredient ID: NPC252067
Ingredient ID: NPC249357
Ingredient ID: NPC244858
Ingredient ID: NPC239039
Ingredient ID: NPC233267
Ingredient ID: NPC232375
Ingredient ID: NPC231738
Ingredient ID: NPC230301
Ingredient ID: NPC228785
Ingredient ID: NPC22484
Ingredient ID: NPC220322
Ingredient ID: NPC218918
Ingredient ID: NPC214909
Ingredient ID: NPC214584
Ingredient ID: NPC213749
Ingredient ID: NPC209275
Ingredient ID: NPC196343
Ingredient ID: NPC195717
Ingredient ID: NPC192638
Ingredient ID: NPC190810
Ingredient ID: NPC18842
Ingredient ID: NPC186098
Ingredient ID: NPC182840
Ingredient ID: NPC180871
Ingredient ID: NPC178638
Ingredient ID: NPC177112
Ingredient ID: NPC176819
Ingredient ID: NPC175987
Ingredient ID: NPC175313
Ingredient ID: NPC173996
Ingredient ID: NPC17112
Ingredient ID: NPC166000
Ingredient ID: NPC1656
Ingredient ID: NPC164958
Ingredient ID: NPC16485
Ingredient ID: NPC163984
Ingredient ID: NPC16287
Ingredient ID: NPC160550
Ingredient ID: NPC157328
Ingredient ID: NPC156353
Ingredient ID: NPC150643
Ingredient ID: NPC144403
Ingredient ID: NPC141777
Ingredient ID: NPC13991
Ingredient ID: NPC139557
Ingredient ID: NPC139546
Ingredient ID: NPC138113
Ingredient ID: NPC131981
Ingredient ID: NPC131769
Ingredient ID: NPC124885
Ingredient ID: NPC123965
Ingredient ID: NPC12269
Ingredient ID: NPC11651
Ingredient ID: NPC114239
Ingredient ID: NPC109813
Ingredient ID: NPC105246
Ingredient ID: NPC105209
Ingredient ID: NPC100773
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Therapeutic Target | Other cytosolic protein | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Therapeutic Target | Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | CNR2 | Cannabinoid CB2 receptor | P34972 | CHEMBL253 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Therapeutic Target | Transcription factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 7 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00346502 | Evaluation of 20% Betulinic Acid Ointment for Treatment of Dysplastic Nevi (Moderate to Severe Dysplasia) | dysplastic nevus | Betulinic Acid (NPC264317) | NP level |
| NCT00701987 | Safety, Tolerability, and Preliminary Efficacy Study of ALS-357 in Patients With Cutaneous Metastatic Melanoma | melanoma | Betulinic Acid (NPC264317) | NP level |
| NCT01119534 | Comparative Efficacy of the Suppository Versus Guaiacol Suppository Versus Guaifenesin Syrup in Pediatric Patients With Cough Due the Infectious Origin | Cough | Camphor (NPC131981) | NP level |
| NCT01119534 | Comparative Efficacy of the Suppository Versus Guaiacol Suppository Versus Guaifenesin Syrup in Pediatric Patients With Cough Due the Infectious Origin | Cough | Eucalyptol (NPC287331) | NP level |
| NCT04392622 | d-Limonene +Radiation +Platinum Based Chemo for Xerostomia Prevention in Locally Advanced Head and Neck Squamous Cell Carcinoma | xerostomia | Limonene (NPC76145) | NP level |
| NCT04853082 | Limonene on Regulating Metabolism-related Fatty Liver Disease (MAFLD) and Analysis of TCM Constitution | Hepatic steatosis | Limonene (NPC76145) | NP level |
| NCT05432284 | Behavioral Pharmacology of THC and Beta-Myrcene | cannabis dependence | Myrcene (NPC138113) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TP53,MAPT
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
F2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA,F2,CNR2,CES1
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
MAPT
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
Arteries/arterioles disorderDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD52 |
MAPK1
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CNR2
|
Attention deficit hyperactivity disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A05 |
CNR2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
