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Ingredient ID: NPC9880
Ingredient ID: NPC96630
Ingredient ID: NPC96218
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Ingredient ID: NPC89069
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Ingredient ID: NPC88566
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Ingredient ID: NPC76145
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Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Therapeutic Target | Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA1D | Alpha-1d adrenergic receptor | P25100 | CHEMBL223 |
Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA1A | Alpha-1a adrenergic receptor | P35348 | CHEMBL229 |
Therapeutic Target | Small molecule receptor (family A GPCR) | CNR2 | Cannabinoid CB2 receptor | P34972 | CHEMBL253 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
![]() | 10 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00966836 | Prevention of Transplant Atherosclerosis With Everolimus and Anti-cytomegalovirus Therapy | cytomegalovirus infection | Phenol (NPC100980) | ![]() |
NCT01119534 | Comparative Efficacy of the Suppository Versus Guaiacol Suppository Versus Guaifenesin Syrup in Pediatric Patients With Cough Due the Infectious Origin | Cough | Camphor (NPC131981) | ![]() |
NCT01197040 | Evaluation of Low Dose Corticosteroids Efficiency, Associated With Myfortic ® in the Treatment of Nephrotic Syndrome | nephrotic syndrome | Phenol (NPC100980) | ![]() |
NCT01468415 | Efficiency Comparison Between Methylprednisolone and Phenol 8% Treatment Using a Trans Sacral Approach - on Lower Back Pain and Limbs | Back pain | Phenol (NPC100980) | ![]() |
NCT01659580 | Phase III Trial of Dantonic® (T89) Capsule to Prevent and Treat Stable Angina | angina pectoris | Borneol (NPC283655) | ![]() |
NCT01705652 | Study to Assess the Activity of Nexrutine® in Prostate Cancer Patients | prostate cancer | Rutin (NPC176740) | ![]() |
NCT01989897 | Effect of HSA or Saline Diluent on Immunotherapy Extract Stability as Determined by Graded ID Skin Tests | allergic rhinitis | Phenol (NPC100980) | ![]() |
NCT02029118 | Acupoint Application in Patients With Stable Angina Pectoris (AASAP) | angina pectoris | Borneol (NPC283655) | ![]() |
NCT04392622 | d-Limonene +Radiation +Platinum Based Chemo for Xerostomia Prevention in Locally Advanced Head and Neck Squamous Cell Carcinoma | xerostomia | Limonene (NPC76145) | ![]() |
NCT04853082 | Limonene on Regulating Metabolism-related Fatty Liver Disease (MAFLD) and Analysis of TCM Constitution | Hepatic steatosis | Limonene (NPC76145) | ![]() |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
CNR1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA9,CA12,F2,ACHE
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
OR51E2,CA9,F2,ACHE,MMP2,CNR2,LMNA
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
OR51E2,FABP5
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
ACHE
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
NCT02029118,NCT01659580 |
Anorexia nervosaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B80 |
CNR1
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2
|