Collective Molecular Activities of the Plant: Cirsium Setosum
Plant ID: NPO11697
Plant Latin Name: Cirsium Setosum
Taxonomy Genus: Cirsium
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
576424
Plant-of-the-World-Online:
n.a.
Country/Region:
ChinaTraditional Medicine System:
TCMChina
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
66 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
46 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
31 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98555
Ingredient ID: NPC85446
Ingredient ID: NPC81010
Ingredient ID: NPC79943
Ingredient ID: NPC79056
Ingredient ID: NPC70388
Ingredient ID: NPC69884
Ingredient ID: NPC52005
Ingredient ID: NPC51843
Ingredient ID: NPC50898
Ingredient ID: NPC44328
Ingredient ID: NPC43300
Ingredient ID: NPC34581
Ingredient ID: NPC32441
Ingredient ID: NPC311621
Ingredient ID: NPC311485
Ingredient ID: NPC305835
Ingredient ID: NPC302857
Ingredient ID: NPC29884
Ingredient ID: NPC290613
Ingredient ID: NPC290437
Ingredient ID: NPC29
Ingredient ID: NPC279121
Ingredient ID: NPC278102
Ingredient ID: NPC268075
Ingredient ID: NPC266441
Ingredient ID: NPC265800
Ingredient ID: NPC261103
Ingredient ID: NPC241498
Ingredient ID: NPC231773
Ingredient ID: NPC231772
Ingredient ID: NPC230301
Ingredient ID: NPC228113
Ingredient ID: NPC227211
Ingredient ID: NPC218109
Ingredient ID: NPC217635
Ingredient ID: NPC217372
Ingredient ID: NPC213935
Ingredient ID: NPC20791
Ingredient ID: NPC205939
Ingredient ID: NPC204932
Ingredient ID: NPC204693
Ingredient ID: NPC202942
Ingredient ID: NPC195945
Ingredient ID: NPC192638
Ingredient ID: NPC188042
Ingredient ID: NPC179950
Ingredient ID: NPC1788
Ingredient ID: NPC176740
Ingredient ID: NPC16728
Ingredient ID: NPC167132
Ingredient ID: NPC157663
Ingredient ID: NPC156655
Ingredient ID: NPC156654
Ingredient ID: NPC156461
Ingredient ID: NPC156353
Ingredient ID: NPC144813
Ingredient ID: NPC142754
Ingredient ID: NPC140616
Ingredient ID: NPC138811
Ingredient ID: NPC130683
Ingredient ID: NPC126102
Ingredient ID: NPC125852
Ingredient ID: NPC12455
Ingredient ID: NPC105025
Ingredient ID: NPC102765
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 79 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00179010 | AMP as a Better Delivery System of Adenosine | ischemia | Adenosine (NPC156461) | NP level |
| NCT00218946 | Nasogastric Tube in Premature Babies - Pain and Treatment | premature birth | Sucrose (NPC130683) | NP level |
| NCT00284323 | Salvage: Postconditioning With Adenosine for STEMI | ST Elevation Myocardial Infarction | Adenosine (NPC156461) | NP level |
| NCT00298636 | Dose-Response of Adenosine for Perioperative Pain | pain | Adenosine (NPC156461) | NP level |
| NCT00330096 | Effects of Hesperidin on Bone Mineral Density and Bone Metabolism of Postmenopausal Women | osteoporosis | Hesperidin (NPC79056) | NP level |
| NCT00349921 | Clonidine Versus Adenosine to Treat Neuropathic Pain | pain | Adenosine (NPC156461) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Quercetin (NPC20791) | NP level |
| NCT00482560 | Analgesic Effect of Breast Feeding vs Sucrose in Neonatal Screening | pain | Sucrose (NPC130683) | NP level |
| NCT00519207 | Evaluation of Topical Liposomal Lidocaine and Oral Sucrose for Treatment of Pain in Newborns Undergoing Venipuncture | pain | Sucrose (NPC130683) | NP level |
| NCT00565188 | Application of ATP Infusions in Palliative Home Care | cancer | Adenosine (NPC156461) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOB,MAOA
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AKR1B1,KDR,DPP4,AURKB
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
FLT3,CDK8,TP53,SRC,AXL,KDM1A,AURKB,PIM1,GSK3B
|
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT00781404
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT04588441,NCT03718507
|
Acute ST elevation myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41.0 |
NCT01747174,NCT00284323
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CDK1,THPO,NPSR1,CA7,XDH,F2,MMP12,AURKB,TTR,ACHE,CA12
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
NPSR1,ADORA2A,CYP2C19,MAOB,ACHE,CES1,ADORA3,CA7,POLB,AURKB,PIM1,AXL,CA14,XDH,HIF1A,CA2,ALOX5,ABCG2,F2,CYP1B1,MET,TTR,DPP4,ALOX15,RECQL
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
NOX4,ALOX15,TTR
NCT01912820 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CDK1,F2,NPSR1,MET,NOX4,MMP12,AURKB,CYP19A1,ALOX15
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
