Collective Molecular Activities of the Plant: Crotalaria Mitchellii
Plant ID: NPO11683
Plant Latin Name: Crotalaria Mitchellii
Taxonomy Genus: Crotalaria
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
59 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
56 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
17 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC90273
Ingredient ID: NPC80043
Ingredient ID: NPC75279
Ingredient ID: NPC71417
Ingredient ID: NPC69394
Ingredient ID: NPC68556
Ingredient ID: NPC6667
Ingredient ID: NPC60857
Ingredient ID: NPC60779
Ingredient ID: NPC42477
Ingredient ID: NPC41020
Ingredient ID: NPC31206
Ingredient ID: NPC306420
Ingredient ID: NPC303672
Ingredient ID: NPC303015
Ingredient ID: NPC300455
Ingredient ID: NPC297249
Ingredient ID: NPC292199
Ingredient ID: NPC282405
Ingredient ID: NPC27765
Ingredient ID: NPC273023
Ingredient ID: NPC26062
Ingredient ID: NPC24631
Ingredient ID: NPC243728
Ingredient ID: NPC241517
Ingredient ID: NPC236166
Ingredient ID: NPC234096
Ingredient ID: NPC230301
Ingredient ID: NPC216432
Ingredient ID: NPC206660
Ingredient ID: NPC201969
Ingredient ID: NPC200651
Ingredient ID: NPC190955
Ingredient ID: NPC186830
Ingredient ID: NPC178613
Ingredient ID: NPC171928
Ingredient ID: NPC1699
Ingredient ID: NPC167028
Ingredient ID: NPC166970
Ingredient ID: NPC166487
Ingredient ID: NPC162276
Ingredient ID: NPC152804
Ingredient ID: NPC152472
Ingredient ID: NPC142229
Ingredient ID: NPC13830
Ingredient ID: NPC134696
Ingredient ID: NPC134337
Ingredient ID: NPC129396
Ingredient ID: NPC120365
Ingredient ID: NPC120203
Ingredient ID: NPC118057
Ingredient ID: NPC115394
Ingredient ID: NPC115383
Ingredient ID: NPC11466
Ingredient ID: NPC113974
Ingredient ID: NPC1077
Ingredient ID: NPC104942
Ingredient ID: NPC103972
Ingredient ID: NPC101582
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | CNR2 | Cannabinoid CB2 receptor | P34972 | CHEMBL253 |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
F2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CNR2,F2
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CNR2
|
Attention deficit hyperactivity disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A05 |
CNR2
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F2
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
F2
|
Cerebral ischaemic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B11 |
F2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
