CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Neomeris Annulata

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO1154
Plant Latin Name: Neomeris Annulata
Taxonomy Genus: Neomeris
Taxonomy Family: Dasycladaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

36 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

18 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

18 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC91887

Ingredient ID: NPC90246

Ingredient ID: NPC78757

Ingredient ID: NPC7013

Ingredient ID: NPC50615

Ingredient ID: NPC44462

Ingredient ID: NPC39426

Ingredient ID: NPC31834

Ingredient ID: NPC300

Ingredient ID: NPC299096

Ingredient ID: NPC28592

Ingredient ID: NPC259370

Ingredient ID: NPC259078

Ingredient ID: NPC256925

Ingredient ID: NPC242414

Ingredient ID: NPC236906

Ingredient ID: NPC234560

Ingredient ID: NPC230028

Ingredient ID: NPC22560

Ingredient ID: NPC207218

Ingredient ID: NPC200636

Ingredient ID: NPC194856

Ingredient ID: NPC186560

Ingredient ID: NPC186397

Ingredient ID: NPC18457

Ingredient ID: NPC157284

Ingredient ID: NPC144247

Ingredient ID: NPC141650

Ingredient ID: NPC135193

Ingredient ID: NPC133970

Ingredient ID: NPC120102

Ingredient ID: NPC119224

Ingredient ID: NPC117992

Ingredient ID: NPC114333

Ingredient ID: NPC110899

Ingredient ID: NPC105881

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Enzyme	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Therapeutic Target	Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Therapeutic Target	Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Therapeutic Target	Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Therapeutic Target	Nuclear hormone receptor subfamily 3	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Therapeutic Target	Nuclear hormone receptor subfamily 3	ESRRA	Estrogen-related receptor alpha	P11474	CHEMBL3429
Therapeutic Target	Nuclear hormone receptor subfamily 3	ESRRB	Estrogen-related receptor beta	O95718	CHEMBL3751
Therapeutic Target	Nuclear hormone receptor subfamily 3	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Therapeutic Target	Oxidoreductase	AOX1	Aldehyde oxidase	Q06278	CHEMBL3257
Therapeutic Target	Phosphodiesterase	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Therapeutic Target	Protein Kinase	MAP2K4	Dual specificity mitogen-activated protein kinase kinase 4	P45985	CHEMBL2897
Therapeutic Target	Serine protease	DPP4	Dipeptidyl peptidase IV	P27487	CHEMBL284
Therapeutic Target	Structural protein	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	24

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00376948	Genistein, Gemcitabine, and Erlotinib in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer	pancreatic carcinoma	Genistein (NPC39426)	NP level
NCT01325311	Cholecalciferol and Genistein Before Surgery in Treating Patients With Early Stage Prostate Cancer	prostate adenocarcinoma	Genistein (NPC39426)	NP level
NCT01985763	Genistein in Treatment of Metastatic Colorectal Cancer	colorectal carcinoma;malignant colon neoplasm;rectum cancer	Genistein (NPC39426)	NP level
NCT00290758	Genistein in Preventing Breast Cancer in Women at High Risk for Breast Cancer	breast cancer	Genistein (NPC39426)	NP level
NCT01489813	Study of Genistein in Reducing Side Effects of Superficial Bladder Cancer Treatment	urinary bladder cancer	Genistein (NPC39426)	NP level
NCT00118040	Phase II Study of Isoflavone G-2535 (Genistein) in Patients With Bladder Cancer	urinary bladder carcinoma	Genistein (NPC39426)	NP level
NCT00016744	Phenylbutyrate/Genistein Duotherapy in Delta F508-Homozygous(for Cystic Fibrosis)	cystic fibrosis	Genistein (NPC39426)	NP level
NCT00005827	Genistein in Treating Patients With Stage II, Stage III, or Stage IV Prostate Cancer	prostate cancer	Genistein (NPC39426)	NP level
NCT00001696	A Pharmacokinetic Study of Genistein, a Tyrosine Kinase Inhibitor	cancer	Genistein (NPC39426)	NP level
NCT00584532	Effects of a Genistein Concentrated Polysaccharide (GCP) for Prostate Cancer on Active Surveillance.	prostate cancer	Genistein (NPC39426)	NP level
NCT02766478	Genistein Supplementation to Mitigate Cardiometabolic Dysfunction in Patients Undergoing Androgen Deprivation Therapy for Prostate Cancer	prostate cancer	Genistein (NPC39426)	NP level
NCT00541710	Effect of Genistein in Women With Metabolic Syndrome	metabolic syndrome	Genistein (NPC39426)	NP level
NCT01628471	MTD Determination, Safety and Efficacy of the Decitabine-Genistein Drug Combination in Advanced Solid Tumors and Non-Small Cell Lung Cancer	non-small cell lung carcinoma	Genistein (NPC39426)	NP level
NCT00590538	Phenylbutyrate/Genistein Duotherapy in Delta F508-Heterozygotes (for Cystic Fibrosis)	cystic fibrosis	Genistein (NPC39426)	NP level
NCT02567799	BIO 300 Non-Small Cell Lung Cancer Study	non-small cell lung carcinoma	Genistein (NPC39426)	NP level
NCT00058266	Genistein in Treating Patients With Localized Prostate Cancer Who Are Planning to Undergo Radical Prostatectomy	prostate cancer	Genistein (NPC39426)	NP level
NCT01126879	Genistein in Treating Patients With Prostate Cancer	prostate adenocarcinoma	Genistein (NPC39426)	NP level
NCT01664650	Effects of Genistein in Postmenopausal Women With Metabolic Syndrome	metabolic syndrome	Genistein (NPC39426)	NP level
NCT00546039	Synthetic Genistein (BONISTEIN™) in Patients Who Are Undergoing Surgery for Prostate Cancer	prostate adenocarcinoma	Genistein (NPC39426)	NP level
NCT00244933	Gemcitabine Hydrochloride and Genistein in Treating Women With Stage IV Breast Cancer	breast cancer	Genistein (NPC39426)	NP level
NCT00882765	Genistein in Treating Patients With Pancreatic Cancer That Can Be Removed by Surgery	pancreatic carcinoma	Genistein (NPC39426)	NP level
NCT00287690	Isoflavones and the Coronary Circulation in Men and Women With Coronary Artery Disease	coronary artery disease	Genistein (NPC39426)	NP level
NCT00010686	Dietary Phytoestrogens and Bone Metabolism	osteoporosis	Genistein (NPC39426);Daidzein (NPC234560)	NP level
NCT04482595	BIO 300 Oral Suspension in Previously Hospitalized Long COVID Patients	pulmonary fibrosis;severe acute respiratory syndrome	Genistein (NPC39426)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	BLM,EGFR,CA12,ESR2,TDP1,AOX1,MAOB,TSHR,LMNA
Prostate cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82	ESR1,AOX1,MAOB,ESR2 NCT00584532,NCT00005827,NCT02766478,NCT00058266
Breast cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C60-2C6Y	ESR2,CA4,CA12,ESR1,EGFR NCT00244933,NCT00290758
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	ESRRA,AOX1,ESR1,EGFR,ESRRB,CA12,CA4
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	EGFR,CA7,CA12,TDP1,AOX1,DPP4,LMNA
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	ESRRB,CA7,TDP1,DPP4,ESRRA,TSHR
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	ESRRB,CA12,ESR1,TDP1,ESRRA,TSHR
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	BLM,CA7,DPP4,CYP2C9,MAOB,LMNA
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	BLM,CA4,CA12,MAPT,CA12,MAPT
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	BLM,CA12,DPP4,AOX1,TSHR,LMNA
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	BLM,CA4,CA12,DPP4,CYP2C9,ESRRA
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	BLM,CA4,ESR2,MAPT,LMNA
Squamous cell carcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.2	BLM,CA7,CA12,CYP2C9,TSHR
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	BLM,CA7,CA12,CYP2C9,TSHR
Malignant neoplasms of adrenal gland Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	BLM,CA4,CA7,CA12,DPP4
Superficial ovarian endometriosis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA10.B4	DPP4,CA4,LMNA,ESRRB
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	ESRRB,DPP4,CYP2C9,MAPT
Carpal tunnel syndrome Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C10.0	ESRRB,ESR1,DPP4,AOX1
Metabolic disorder Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C50-5D2Z	DPP4 NCT00541710,NCT01664650
Non-small cell lung cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25	EGFR NCT01628471,NCT02567799
Bacterial infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1A00-1C4Z	CYP2C9,CA12,CA4
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	MAPT,MAOB,ESR2
Psoriasis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA90	ESRRA,ESRRB,DPP4
Vasomotor/allergic rhinitis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA08	ESRRA,ESRRB,ESR2
Asthma Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA23	ESRRA,ESRRB,CA4
Adenocarcinoma of prostate Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82.0	NCT00546039,NCT01325311,NCT01126879
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	BLM,CA4,MAPT
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	BLM,CA12,CA4
Leishmaniasis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F54	BLM,DPP4,TSHR
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	CYP2C9,ESR2,ESRRB
Malignant neoplasms of thyroid gland, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D10.Z	CA7,DPP4,CA12
Malignant neoplasms of corpus uteri, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.Z	BLM,ESRRB,CYP2C9
Chikungunya virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D40	EGFR,LMNA,ESRRB
Invasive carcinoma of breast Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C61	BLM,CA12,ESR1
Seborrhoeic dermatitis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA81	CA12,CA4
Postoperative inflammation Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1A00-CA43	ESRRB,ESRRA
Diabetes mellitus, type unspecified Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A14	DPP4,ESR1
Hyper-lipoproteinaemia Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C80	ESR1,ESR2
Contact dermatitis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EK00-EK0Z	ESRRA,ESRRB
Colorectal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B91	EGFR NCT01985763
Parkinsonism Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A00	MAPT,MAOB
Inflammatory arthropathy Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA2Z	ESRRB,ESRRA
Atopic eczema Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA80	ESRRB,ESRRA
Hepatitis virus infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1E50-1E51	EGFR,ESR2
Eyelid inflammatory disorder Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9A02	ESRRB,ESRRA
Menopausal disorder Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA30	ESR2,ESR1
Skin disease Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA00-EM0Z	ESRRA,ESRRB
Brain cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00	EGFR,ESR1
Cystic fibrosis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA25	NCT00016744,NCT00590538
Malignant neoplasm of pancreas, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.Z	NCT00376948,NCT00882765
Myelodysplastic syndromes, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A3Z	TSHR,CYP2C9
Other specified malignant neoplasms of kidney, except renal pelvis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90.Y	CYP2C9,TSHR
Tetralogy of Fallot Disease Category: 20.Developmental anomalies Disease ICD-11 Code: LA88.2	CA4,ESRRB
Urothelial carcinoma of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94.2	BLM,CYP2C9
Renal cell carcinoma, chromophobe type Disease Category: X.Extension Codes Disease ICD-11 Code: XH6153	CA12,ESRRA
Rheumatoid arthritis Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA20	ESRRA
Female infertility Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA31	ESR1
Malaria Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F40-1F45	MAOB
Malignant haematopoietic neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B33	DPP4
Testicular cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80	EGFR
Glaucoma Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9C61	CA4
Mature B-cell leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A82	EGFR
Myocardial infarction Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA41-BA43	DPP4
Male infertility Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GB04	ESR1
Muscular dystrophy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C70	MAOB
Degenerative high myopia Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9B76	ESRRA
Chronic arterial occlusive disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD4Z	DPP4
Metastatic lymph node neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D60	EGFR
Acne vulgaris Disease Category: 14.Diseases of the skin Disease ICD-11 Code: ED80	ESR1
Acute diabete complication Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A2Y	DPP4
Unspecified viral infection of unspecified site Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D9Z	ESR1
Colon cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B90	EGFR
Indeterminate colitis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD72	ESR2
Thyroid cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D10	TSHR
Renal cell carcinoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90	EGFR
Stomach cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72	EGFR
Skeletal anomaly Disease Category: 20.Developmental anomalies Disease ICD-11 Code: LD24	ESR1
Malignant mesenchymal neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B5D-2B5Y	EGFR
Skin tag/polyp Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EK71	MAOB
Lung cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25	EGFR
Dyspareunia Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA12	ESR1
Intracerebral haemorrhage Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B00	EGFR
Endometriosis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA10	ESR1
Vaginitis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA02	ESR1
Type 2 diabetes mellitus Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A11	DPP4
Mild neurocognitive disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6D71	MAPT
Choreiform disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A01	MAPT
Low bone mass disorder Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FB83	ESR1
Diabetic foot ulcer Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD54	EGFR
Primary psychotic disorder manifestation Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A25	MAOB
Skin postprocedural disorder Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EL8Y	EGFR
Breast in situ carcinoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2E65	ESR1
Cushing syndrome Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A70	ESR2
Prostate hyperplasia Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA90	ESR2
Nasopharyngeal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B6B	EGFR
Acquired prion disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8E01	ESR1
Hypopharyngeal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B6D	EGFR
Schizophrenia Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A20	ESRRA
Female pelvic pain Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA34	ESR1
Unspecific body region injury Disease Category: 22.Injury, poisoning or certain other consequences of external causes Disease ICD-11 Code: ND56	EGFR
Chronic pain Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG30	EGFR
General pain disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8E43	MAOB
Metastatic biliary tract neoplasms Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C14-2C17	EGFR
Skin cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C30-2C37	MAOB
Angina pectoris Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA40	EGFR
Pancreatic cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10	EGFR
Urethral cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C93	EGFR
Pulmonary hypertension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BB01	MAOB
Nausea/vomiting Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MD90	MAOB
Sepsis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1G40-1G41	ESR2
Spinal cord/cranial nerve neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A02	EGFR
Multiple sclerosis Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A40	ESR1
Adrenal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	ESR1
Ischemia Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B10-8B11	EGFR
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	MAPT
Autism spectrum disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A02	DPP4
Female genital tract noninflammatory disorder Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA1Y	ESR1
Menstrual cycle bleeding disorder Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA20	ESR1
Metastatic tumour Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D50-2E2Z	ESR1
Melanoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C30	EGFR
Vitamin deficiency Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5B55-5B5F	AOX1
Mature T-cell lymphoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A90	EGFR
Hypo-thyroidism Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A00	TSHR
Myelodysplastic syndrome Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A37	EGFR
Pituitary gland disorder Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A60-5A61	ESR1
Acquired hypomelanotic disorder Disease Category: 14.Diseases of the skin Disease ICD-11 Code: ED63	MAOB
Head and neck cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D42	EGFR
Dementia Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6D80-6D8Z	MAOB
Depression Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A70-6A7Z	MAOB
Liver cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12	EGFR
Migraine Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A80	MAOB
Osteoporosis Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FB83.1	NCT00010686
Malignant neoplasms of bladder, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94.Z	NCT01489813
Severe acute respiratory syndrome Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D65	NCT04482595
Rectum cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B92	NCT01985763
Malignant neoplasms of colon Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B90	NCT01985763
coronary artery disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA8Y-BA8Z	NCT00287690
Idiopathic pulmonary fibrosis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CB03.4	NCT04482595
Neoplasms of unknown behaviour of urinary organs Disease Category: 02.Neoplasms Disease ICD-11 Code: 2F98	NCT00118040
Unspecified malignant neoplasms of unspecified sites Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D4Z	NCT00001696
Coeliac disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DA95	TSHR
Osteoarthritis, unspecified Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA0Z	CA12
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	BLM
Atrial fibrillation Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BC81.3	CA7
Keratoconus Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9A78.50	CA4
West Nile virus infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D46	DPP4
Pre-eclampsia Disease Category: 18.Pregnancy, childbirth or the puerperium Disease ICD-11 Code: JA24	CA4
Pneumonia due to Pseudomonasaeruginosa Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA40.05	DPP4
Other specified malignant neoplasms of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.Y	CA12
Malignant neoplasms of oesophagus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B70	BLM
Systemic lupus erythematosus Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A40.0	ESRRB
Gliomas of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.0	BLM

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Neomeris Annulata

Click for details-----ITS

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Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

36 All known Ingredients in Total

18 Ingredients with Acceptable Bioavailablity

18 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Diffuse large B-cell lymphomas

Prostate cancer

Breast cancer

Solid tumour/cancer

Mesothelioma of pleura

Carcinosarcoma of uterus

Serous cystadenoma,borderline malignancy of ovary

Adenocarcinoma of pancreas

Hepatocellular carcinoma of liver

Glioblastoma of brain

Germ cell tumour of testis

Malignant neoplasms of biliary tract, distal bile duct

Squamous cell carcinoma of bronchus or lung

Adenocarcinoma of bronchus or lung

Malignant neoplasms of adrenal gland

Superficial ovarian endometriosis

Malignant neoplasms of thymus

Carpal tunnel syndrome

Metabolic disorder

Non-small cell lung cancer

Bacterial infection

Alzheimer disease

Psoriasis

Vasomotor/allergic rhinitis

Asthma

Adenocarcinoma of prostate

Pheochromocytoma

Hepatoblastoma

Leishmaniasis

Cytomegaloviral disease

Malignant neoplasms of thyroid gland, unspecified

Malignant neoplasms of corpus uteri, unspecified

Chikungunya virus disease

Invasive carcinoma of breast

Seborrhoeic dermatitis

Postoperative inflammation

Diabetes mellitus, type unspecified

Hyper-lipoproteinaemia

Contact dermatitis

Colorectal cancer

Parkinsonism

Inflammatory arthropathy

Atopic eczema

Hepatitis virus infection

Eyelid inflammatory disorder

Menopausal disorder

Skin disease

Brain cancer

Cystic fibrosis

Malignant neoplasm of pancreas, unspecified

Myelodysplastic syndromes, unspecified

Other specified malignant neoplasms of kidney, except renal pelvis

Tetralogy of Fallot

Urothelial carcinoma of bladder

Renal cell carcinoma, chromophobe type

Rheumatoid arthritis

Female infertility

Malaria

Malignant haematopoietic neoplasm

Testicular cancer

Glaucoma

Mature B-cell leukaemia

Myocardial infarction

Male infertility