Collective Molecular Activities of the Plant: Akebia Trifoliata
Plant ID: NPO11170
Plant Latin Name: Akebia Trifoliata
Taxonomy Genus: Akebia
Taxonomy Family: Lardizabalaceae
Plant External Links:
NCBI TaxonomyDB:
155132
Plant-of-the-World-Online:
n.a.
Country/Region:
ChinaTraditional Medicine System:
TCMMedicinal Functions:
Analgesic; Antibacterial; Antifungal; Antiinflammatory; Antitumor; Blood tonic; Cardiotonic; Diuretic; Emmenagogue; Galactogogue
China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
225 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
193 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
132 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99886
Ingredient ID: NPC96630
Ingredient ID: NPC95675
Ingredient ID: NPC94368
Ingredient ID: NPC91962
Ingredient ID: NPC91574
Ingredient ID: NPC90701
Ingredient ID: NPC89069
Ingredient ID: NPC88566
Ingredient ID: NPC86954
Ingredient ID: NPC85813
Ingredient ID: NPC85661
Ingredient ID: NPC84030
Ingredient ID: NPC82295
Ingredient ID: NPC78551
Ingredient ID: NPC78500
Ingredient ID: NPC78479
Ingredient ID: NPC76145
Ingredient ID: NPC75158
Ingredient ID: NPC75121
Ingredient ID: NPC7491
Ingredient ID: NPC71703
Ingredient ID: NPC71506
Ingredient ID: NPC69271
Ingredient ID: NPC68889
Ingredient ID: NPC66681
Ingredient ID: NPC66577
Ingredient ID: NPC63704
Ingredient ID: NPC59581
Ingredient ID: NPC59570
Ingredient ID: NPC58970
Ingredient ID: NPC58478
Ingredient ID: NPC57879
Ingredient ID: NPC57877
Ingredient ID: NPC56112
Ingredient ID: NPC55181
Ingredient ID: NPC54264
Ingredient ID: NPC53720
Ingredient ID: NPC52700
Ingredient ID: NPC52403
Ingredient ID: NPC52309
Ingredient ID: NPC49151
Ingredient ID: NPC46679
Ingredient ID: NPC45270
Ingredient ID: NPC44751
Ingredient ID: NPC42471
Ingredient ID: NPC42403
Ingredient ID: NPC41180
Ingredient ID: NPC40249
Ingredient ID: NPC39633
Ingredient ID: NPC39068
Ingredient ID: NPC38497
Ingredient ID: NPC37644
Ingredient ID: NPC36408
Ingredient ID: NPC34764
Ingredient ID: NPC323787
Ingredient ID: NPC32279
Ingredient ID: NPC315507
Ingredient ID: NPC312132
Ingredient ID: NPC310478
Ingredient ID: NPC309982
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Ingredient ID: NPC308218
Ingredient ID: NPC303979
Ingredient ID: NPC303683
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Ingredient ID: NPC302327
Ingredient ID: NPC301964
Ingredient ID: NPC301696
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Ingredient ID: NPC297608
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Ingredient ID: NPC287331
Ingredient ID: NPC285716
Ingredient ID: NPC28545
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Ingredient ID: NPC283655
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Ingredient ID: NPC273545
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Ingredient ID: NPC26906
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Ingredient ID: NPC25275
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Ingredient ID: NPC213749
Ingredient ID: NPC213449
Ingredient ID: NPC210040
Ingredient ID: NPC209275
Ingredient ID: NPC209166
Ingredient ID: NPC208936
Ingredient ID: NPC208075
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Ingredient ID: NPC207115
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Ingredient ID: NPC201844
Ingredient ID: NPC199958
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Ingredient ID: NPC186098
Ingredient ID: NPC185189
Ingredient ID: NPC182840
Ingredient ID: NPC181089
Ingredient ID: NPC180871
Ingredient ID: NPC180684
Ingredient ID: NPC179831
Ingredient ID: NPC178223
Ingredient ID: NPC177112
Ingredient ID: NPC176819
Ingredient ID: NPC176309
Ingredient ID: NPC175342
Ingredient ID: NPC174679
Ingredient ID: NPC174368
Ingredient ID: NPC174365
Ingredient ID: NPC17408
Ingredient ID: NPC173996
Ingredient ID: NPC171063
Ingredient ID: NPC169222
Ingredient ID: NPC168855
Ingredient ID: NPC167976
Ingredient ID: NPC167385
Ingredient ID: NPC166894
Ingredient ID: NPC1656
Ingredient ID: NPC163984
Ingredient ID: NPC163520
Ingredient ID: NPC16157
Ingredient ID: NPC161097
Ingredient ID: NPC160996
Ingredient ID: NPC156750
Ingredient ID: NPC155263
Ingredient ID: NPC154466
Ingredient ID: NPC153958
Ingredient ID: NPC152438
Ingredient ID: NPC150212
Ingredient ID: NPC150031
Ingredient ID: NPC149193
Ingredient ID: NPC147343
Ingredient ID: NPC14682
Ingredient ID: NPC142753
Ingredient ID: NPC142415
Ingredient ID: NPC13991
Ingredient ID: NPC139546
Ingredient ID: NPC138113
Ingredient ID: NPC137949
Ingredient ID: NPC13789
Ingredient ID: NPC137425
Ingredient ID: NPC136165
Ingredient ID: NPC135648
Ingredient ID: NPC135388
Ingredient ID: NPC135077
Ingredient ID: NPC133600
Ingredient ID: NPC131981
Ingredient ID: NPC131769
Ingredient ID: NPC128825
Ingredient ID: NPC125144
Ingredient ID: NPC122487
Ingredient ID: NPC122086
Ingredient ID: NPC119381
Ingredient ID: NPC114239
Ingredient ID: NPC109813
Ingredient ID: NPC108218
Ingredient ID: NPC106250
Ingredient ID: NPC105329
Ingredient ID: NPC105171
Ingredient ID: NPC104323
Ingredient ID: NPC101285
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Membrane receptor | APP | Beta amyloid A4 protein | P05067 | CHEMBL2487 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Therapeutic Target | Oxidoreductase | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Therapeutic Target | Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 42 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00029679 | Borage Oil and Ginkgo Biloba (EGb 761) in Asthma | asthma | Linoleic Acid (NPC85813) | NP level |
| NCT00204932 | Effects of CLA Supplements on Body Weight and Fat Oxidation | obesity | Linoleic Acid (NPC85813) | NP level |
| NCT00299559 | Kinetics of Etheric Oils, Smart Textiles vs. Ointment | common cold | Menthol (NPC223468) | NP level |
| NCT00607945 | Dietary Fatty Acids as Complementary Therapy in Type 2 Diabetes Mellitus | type 2 diabetes mellitus | Linoleic Acid (NPC85813) | NP level |
| NCT00848172 | Double-Blind, Placebo Controlled Pilot Study of Octanoic Acid in Essential Tremor | essential tremor | Octanoic Acid (NPC301696) | NP level |
| NCT00908791 | Proof of Principle Trial to Determine if Nutritional Supplement Conjugated Linoleic Acid (CLA) Can Modulate the Lipogenic Pathway in Breast Cancer Tissue | breast cancer | Linoleic Acid (NPC85813) | NP level |
| NCT00951158 | A Molecular Pharmacodynamic Dose-titration Trial of Conjugated Linoleic Acid (CLA; Clarinol®) in Patients With Advanced Solid Tumors | neoplasm | Linoleic Acid (NPC85813) | NP level |
| NCT01119534 | Comparative Efficacy of the Suppository Versus Guaiacol Suppository Versus Guaifenesin Syrup in Pediatric Patients With Cough Due the Infectious Origin | Cough | Menthol (NPC223468);Camphor (NPC131981) | NP level |
| NCT01119534 | Comparative Efficacy of the Suppository Versus Guaiacol Suppository Versus Guaifenesin Syrup in Pediatric Patients With Cough Due the Infectious Origin | Cough | Eucalyptol (NPC287331) | NP level |
| NCT01408446 | Effects and Safety of Menthol on Blood Pressure and Metabolic Parameters in Prehypertensive and Mild Hypertensive Patients | hypertension | Menthol (NPC223468) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
PTPN1,AKR1B1,FFAR1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
PTPRC,TP53
NCT02472626 |
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,TSHR,SLCO1B3,CA9,AKR1B10,AKR1C3
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CDC25B,LMNA,ALOX15,CES1,FABP3,FFAR4,CNR2,APP,SLCO1B3,CA9,AKR1B10,OR51E2,PTPRC,PTPN1,AKR1C3
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
ALOX15,FABP5,SLCO1B3,OR51E2
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CDC25B,ALOX15,SLCO1B3
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
APP
|
AmyloidosisDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5D00 |
APP
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
NCT01659580,NCT02029118
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
