Collective Molecular Activities of the Plant: Epimedium Sagittatum
Country/Region:
ChinaTraditional Medicine System:
TCMMedicinal Functions:
Antirheumatic; Aphrodisiac; Carminative; Expectorant; Infertility; Kidney; Ophthalmic; Tonic; Vasodilator
Japan; China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
163 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
99 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
66 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98745
Ingredient ID: NPC98356
Ingredient ID: NPC97804
Ingredient ID: NPC96152
Ingredient ID: NPC9611
Ingredient ID: NPC94399
Ingredient ID: NPC93500
Ingredient ID: NPC92844
Ingredient ID: NPC9117
Ingredient ID: NPC88789
Ingredient ID: NPC87397
Ingredient ID: NPC8659
Ingredient ID: NPC86054
Ingredient ID: NPC85813
Ingredient ID: NPC85346
Ingredient ID: NPC8396
Ingredient ID: NPC81775
Ingredient ID: NPC81010
Ingredient ID: NPC76648
Ingredient ID: NPC75425
Ingredient ID: NPC74604
Ingredient ID: NPC74304
Ingredient ID: NPC7365
Ingredient ID: NPC72722
Ingredient ID: NPC71786
Ingredient ID: NPC71536
Ingredient ID: NPC71347
Ingredient ID: NPC70759
Ingredient ID: NPC67308
Ingredient ID: NPC67020
Ingredient ID: NPC66087
Ingredient ID: NPC65786
Ingredient ID: NPC62765
Ingredient ID: NPC62254
Ingredient ID: NPC61477
Ingredient ID: NPC60
Ingredient ID: NPC5319
Ingredient ID: NPC5173
Ingredient ID: NPC50898
Ingredient ID: NPC4920
Ingredient ID: NPC47724
Ingredient ID: NPC40233
Ingredient ID: NPC3936
Ingredient ID: NPC39
Ingredient ID: NPC34103
Ingredient ID: NPC320283
Ingredient ID: NPC319463
Ingredient ID: NPC318533
Ingredient ID: NPC317489
Ingredient ID: NPC31428
Ingredient ID: NPC311256
Ingredient ID: NPC311000
Ingredient ID: NPC31092
Ingredient ID: NPC308718
Ingredient ID: NPC306590
Ingredient ID: NPC306207
Ingredient ID: NPC305987
Ingredient ID: NPC304870
Ingredient ID: NPC303430
Ingredient ID: NPC302857
Ingredient ID: NPC302293
Ingredient ID: NPC299856
Ingredient ID: NPC299804
Ingredient ID: NPC29883
Ingredient ID: NPC298049
Ingredient ID: NPC294902
Ingredient ID: NPC29183
Ingredient ID: NPC291704
Ingredient ID: NPC290926
Ingredient ID: NPC290613
Ingredient ID: NPC29
Ingredient ID: NPC288298
Ingredient ID: NPC286788
Ingredient ID: NPC282086
Ingredient ID: NPC281131
Ingredient ID: NPC279980
Ingredient ID: NPC279696
Ingredient ID: NPC279121
Ingredient ID: NPC278419
Ingredient ID: NPC278068
Ingredient ID: NPC273699
Ingredient ID: NPC273538
Ingredient ID: NPC269171
Ingredient ID: NPC268312
Ingredient ID: NPC26782
Ingredient ID: NPC264779
Ingredient ID: NPC26417
Ingredient ID: NPC258552
Ingredient ID: NPC25675
Ingredient ID: NPC253729
Ingredient ID: NPC253487
Ingredient ID: NPC252558
Ingredient ID: NPC250543
Ingredient ID: NPC249714
Ingredient ID: NPC242149
Ingredient ID: NPC240735
Ingredient ID: NPC239687
Ingredient ID: NPC238010
Ingredient ID: NPC237460
Ingredient ID: NPC236709
Ingredient ID: NPC234560
Ingredient ID: NPC230301
Ingredient ID: NPC226676
Ingredient ID: NPC225710
Ingredient ID: NPC224731
Ingredient ID: NPC224714
Ingredient ID: NPC219913
Ingredient ID: NPC219876
Ingredient ID: NPC219053
Ingredient ID: NPC216489
Ingredient ID: NPC212625
Ingredient ID: NPC211773
Ingredient ID: NPC20791
Ingredient ID: NPC200528
Ingredient ID: NPC199191
Ingredient ID: NPC198251
Ingredient ID: NPC197606
Ingredient ID: NPC193375
Ingredient ID: NPC184049
Ingredient ID: NPC180968
Ingredient ID: NPC179950
Ingredient ID: NPC179198
Ingredient ID: NPC179169
Ingredient ID: NPC176740
Ingredient ID: NPC175819
Ingredient ID: NPC174249
Ingredient ID: NPC173265
Ingredient ID: NPC172653
Ingredient ID: NPC170526
Ingredient ID: NPC167976
Ingredient ID: NPC165159
Ingredient ID: NPC163294
Ingredient ID: NPC15658
Ingredient ID: NPC155025
Ingredient ID: NPC153572
Ingredient ID: NPC151923
Ingredient ID: NPC145858
Ingredient ID: NPC145038
Ingredient ID: NPC144764
Ingredient ID: NPC142931
Ingredient ID: NPC142703
Ingredient ID: NPC141768
Ingredient ID: NPC141765
Ingredient ID: NPC139548
Ingredient ID: NPC135088
Ingredient ID: NPC131745
Ingredient ID: NPC129841
Ingredient ID: NPC121497
Ingredient ID: NPC120926
Ingredient ID: NPC12053
Ingredient ID: NPC120464
Ingredient ID: NPC119307
Ingredient ID: NPC116775
Ingredient ID: NPC114979
Ingredient ID: NPC113212
Ingredient ID: NPC111929
Ingredient ID: NPC111888
Ingredient ID: NPC109813
Ingredient ID: NPC108960
Ingredient ID: NPC1075
Ingredient ID: NPC107451
Ingredient ID: NPC104387
Ingredient ID: NPC103264
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 49 | |
 Plant level | 1 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00010686 | Dietary Phytoestrogens and Bone Metabolism | osteoporosis | Daidzein (NPC234560) | NP level |
| NCT00029679 | Borage Oil and Ginkgo Biloba (EGb 761) in Asthma | asthma | Linoleic Acid (NPC85813) | NP level |
| NCT00204932 | Effects of CLA Supplements on Body Weight and Fat Oxidation | obesity | Linoleic Acid (NPC85813) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Quercetin (NPC20791) | NP level |
| NCT00607945 | Dietary Fatty Acids as Complementary Therapy in Type 2 Diabetes Mellitus | type 2 diabetes mellitus | Linoleic Acid (NPC85813) | NP level |
| NCT00908791 | Proof of Principle Trial to Determine if Nutritional Supplement Conjugated Linoleic Acid (CLA) Can Modulate the Lipogenic Pathway in Breast Cancer Tissue | breast cancer | Linoleic Acid (NPC85813) | NP level |
| NCT00951158 | A Molecular Pharmacodynamic Dose-titration Trial of Conjugated Linoleic Acid (CLA; Clarinol®) in Patients With Advanced Solid Tumors | neoplasm | Linoleic Acid (NPC85813) | NP level |
| NCT01278810 | Phase I Study of Novel Estrogen Receptor(ER) a36 Modifier Icaritin in Advanced Breast Cancer Patients | breast cancer | Icaritin (NPC273538) | NP level |
| NCT01348204 | Nasal Potential Studies Utilizing Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators | cystic fibrosis | Quercetin (NPC20791) | NP level |
| NCT01375101 | Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus | oral lichen planus | Quercetin (NPC20791) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2,ESR1
|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
FFAR1,DPP4,KDR,AKR1B1,AURKB
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
PIM1,GSK3B,TP53,AURKB,SRC,AXL,FLT3,KDM1A,NFKB1
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ACHE,AKR1C3,BLM,MMP1,MMP12,CA7,F2,XDH,TTR,THPO,CYP2C9,CDK1,CA12,TSHR,MMP9,AURKB,NPSR1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ACHE,AKR1C3,BLM,CA2,MMP1,ALOX15,FABP3,CA7,ABCG2,NAPRT,F2,FUT7,XDH,POLB,TTR,RECQL,DPP4,PIM1,CISD1,LMNA,MMP2,HSD17B2,CYP1B1,CYP2C9,FFAR4,AXL,CNR2,ALOX5,DRD1,HIF1A,MET,AURKB,NPSR1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
