Plant ID: NPO10906
Plant Latin Name: Pinus Koraiensis
Taxonomy Genus: Pinus
Taxonomy Family: Pinaceae
NCBI TaxonomyDB:
88728
Plant-of-the-World-Online:
n.a.
Analgesic; Antibacterial; Antiinflammatory; Galactogogue; Poultice
China; Russia
Ingredient ID: NPC98442
Ingredient ID: NPC97315
Ingredient ID: NPC95868
Ingredient ID: NPC91382
Ingredient ID: NPC85813
Ingredient ID: NPC77272
Ingredient ID: NPC76145
Ingredient ID: NPC6095
Ingredient ID: NPC55907
Ingredient ID: NPC48853
Ingredient ID: NPC479462
Ingredient ID: NPC479461
Ingredient ID: NPC479460
Ingredient ID: NPC479459
Ingredient ID: NPC479458
Ingredient ID: NPC479457
Ingredient ID: NPC479456
Ingredient ID: NPC479455
Ingredient ID: NPC479454
Ingredient ID: NPC479453
Ingredient ID: NPC479452
Ingredient ID: NPC479451
Ingredient ID: NPC44581
Ingredient ID: NPC424
Ingredient ID: NPC39426
Ingredient ID: NPC38059
Ingredient ID: NPC37009
Ingredient ID: NPC36061
Ingredient ID: NPC35543
Ingredient ID: NPC34764
Ingredient ID: NPC300956
Ingredient ID: NPC294548
Ingredient ID: NPC290178
Ingredient ID: NPC281972
Ingredient ID: NPC277693
Ingredient ID: NPC266535
Ingredient ID: NPC261831
Ingredient ID: NPC257976
Ingredient ID: NPC252107
Ingredient ID: NPC236431
Ingredient ID: NPC234560
Ingredient ID: NPC229465
Ingredient ID: NPC216630
Ingredient ID: NPC209970
Ingredient ID: NPC20764
Ingredient ID: NPC187095
Ingredient ID: NPC186903
Ingredient ID: NPC177251
Ingredient ID: NPC171736
Ingredient ID: NPC169075
Ingredient ID: NPC168661
Ingredient ID: NPC16452
Ingredient ID: NPC164203
Ingredient ID: NPC159714
Ingredient ID: NPC159505
Ingredient ID: NPC154932
Ingredient ID: NPC154772
Ingredient ID: NPC154079
Ingredient ID: NPC151752
Ingredient ID: NPC149184
Ingredient ID: NPC146197
Ingredient ID: NPC141032
Ingredient ID: NPC139029
Ingredient ID: NPC137972
Ingredient ID: NPC12154
Ingredient ID: NPC115798
Ingredient ID: NPC110290
Ingredient ID: NPC105708
Ingredient ID: NPC100165
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
Therapeutic Target | Enzyme | NOS1 | Nitric-oxide synthase, brain | P29475 | CHEMBL3568 |
Therapeutic Target | Enzyme | NOS3 | Nitric-oxide synthase, endothelial | P29474 | CHEMBL4803 |
Therapeutic Target | Enzyme | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
Therapeutic Target | Fatty acid binding protein family | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Therapeutic Target | Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
Therapeutic Target | Nuclear hormone receptor subfamily 1 | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESRRA | Estrogen-related receptor alpha | P11474 | CHEMBL3429 |
Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESR1 | Estrogen receptor alpha | P03372 | CHEMBL206 |
Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESRRB | Estrogen-related receptor beta | O95718 | CHEMBL3751 |
Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
Therapeutic Target | Oxidoreductase | AOX1 | Aldehyde oxidase | Q06278 | CHEMBL3257 |
Therapeutic Target | Oxidoreductase | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
Therapeutic Target | Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
Therapeutic Target | Phosphodiesterase | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
Therapeutic Target | Protein Kinase | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | P45985 | CHEMBL2897 |
Therapeutic Target | Serine protease | DPP4 | Dipeptidyl peptidase IV | P27487 | CHEMBL284 |
Therapeutic Target | Small molecule receptor (family A GPCR) | FFAR4 | G-protein coupled receptor 120 | Q5NUL3 | CHEMBL5339 |
Therapeutic Target | Small molecule receptor (family A GPCR) | FFAR1 | Free fatty acid receptor 1 | O14842 | CHEMBL4422 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 35 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00016744 | Phenylbutyrate/Genistein Duotherapy in Delta F508-Homozygous(for Cystic Fibrosis) | cystic fibrosis | Genistein (NPC39426) | NP level |
NCT00376948 | Genistein, Gemcitabine, and Erlotinib in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer | pancreatic carcinoma | Genistein (NPC39426) | NP level |
NCT00590538 | Phenylbutyrate/Genistein Duotherapy in Delta F508-Heterozygotes (for Cystic Fibrosis) | cystic fibrosis | Genistein (NPC39426) | NP level |
NCT01664650 | Effects of Genistein in Postmenopausal Women With Metabolic Syndrome | metabolic syndrome | Genistein (NPC39426) | NP level |
NCT00290758 | Genistein in Preventing Breast Cancer in Women at High Risk for Breast Cancer | breast cancer | Genistein (NPC39426) | NP level |
NCT00244933 | Gemcitabine Hydrochloride and Genistein in Treating Women With Stage IV Breast Cancer | breast cancer | Genistein (NPC39426) | NP level |
NCT04853082 | Limonene on Regulating Metabolism-related Fatty Liver Disease (MAFLD) and Analysis of TCM Constitution | Hepatic steatosis | Limonene (NPC76145) | NP level |
NCT01792310 | A Phase 1/2A Study of LAM561 in Adult Patients With Advanced Solid Tumours | glioma | Oleic Acid (NPC261831) | NP level |
NCT00029679 | Borage Oil and Ginkgo Biloba (EGb 761) in Asthma | asthma | Linoleic Acid (NPC85813) | NP level |
NCT00058266 | Genistein in Treating Patients With Localized Prostate Cancer Who Are Planning to Undergo Radical Prostatectomy | prostate cancer | Genistein (NPC39426) | NP level |
NCT00638196 | Placebo vs. Linoleic Acid Controlled Assessment of Treatment Efficacy in MS | multiple sclerosis | Oleic Acid (NPC261831) | NP level |
NCT01489813 | Study of Genistein in Reducing Side Effects of Superficial Bladder Cancer Treatment | urinary bladder cancer | Genistein (NPC39426) | NP level |
NCT01126879 | Genistein in Treating Patients With Prostate Cancer | prostate adenocarcinoma | Genistein (NPC39426) | NP level |
NCT00001696 | A Pharmacokinetic Study of Genistein, a Tyrosine Kinase Inhibitor | cancer | Genistein (NPC39426) | NP level |
NCT04392622 | d-Limonene +Radiation +Platinum Based Chemo for Xerostomia Prevention in Locally Advanced Head and Neck Squamous Cell Carcinoma | xerostomia | Limonene (NPC76145) | NP level |
NCT00118040 | Phase II Study of Isoflavone G-2535 (Genistein) in Patients With Bladder Cancer | urinary bladder carcinoma | Genistein (NPC39426) | NP level |
NCT00882765 | Genistein in Treating Patients With Pancreatic Cancer That Can Be Removed by Surgery | pancreatic carcinoma | Genistein (NPC39426) | NP level |
NCT00607945 | Dietary Fatty Acids as Complementary Therapy in Type 2 Diabetes Mellitus | type 2 diabetes mellitus | Linoleic Acid (NPC85813) | NP level |
NCT00951158 | A Molecular Pharmacodynamic Dose-titration Trial of Conjugated Linoleic Acid (CLA; Clarinol®) in Patients With Advanced Solid Tumors | neoplasm | Linoleic Acid (NPC85813) | NP level |
NCT01628471 | MTD Determination, Safety and Efficacy of the Decitabine-Genistein Drug Combination in Advanced Solid Tumors and Non-Small Cell Lung Cancer | non-small cell lung carcinoma | Genistein (NPC39426) | NP level |
NCT01325311 | Cholecalciferol and Genistein Before Surgery in Treating Patients With Early Stage Prostate Cancer | prostate adenocarcinoma | Genistein (NPC39426) | NP level |
NCT00546039 | Synthetic Genistein (BONISTEIN™) in Patients Who Are Undergoing Surgery for Prostate Cancer | prostate adenocarcinoma | Genistein (NPC39426) | NP level |
NCT00005827 | Genistein in Treating Patients With Stage II, Stage III, or Stage IV Prostate Cancer | prostate cancer | Genistein (NPC39426) | NP level |
NCT01661764 | Fish Oil Supplementation, Nutrigenomics and Colorectal Cancer Prevention | colorectal adenoma | Oleic Acid (NPC261831) | NP level |
NCT04482595 | BIO 300 Oral Suspension in Previously Hospitalized Long COVID Patients | pulmonary fibrosis;severe acute respiratory syndrome | Genistein (NPC39426) | NP level |
NCT00204932 | Effects of CLA Supplements on Body Weight and Fat Oxidation | obesity | Linoleic Acid (NPC85813) | NP level |
NCT02567799 | BIO 300 Non-Small Cell Lung Cancer Study | non-small cell lung carcinoma | Genistein (NPC39426) | NP level |
NCT00010686 | Dietary Phytoestrogens and Bone Metabolism | osteoporosis | Daidzein (NPC234560);Genistein (NPC39426) | NP level |
NCT00908791 | Proof of Principle Trial to Determine if Nutritional Supplement Conjugated Linoleic Acid (CLA) Can Modulate the Lipogenic Pathway in Breast Cancer Tissue | breast cancer | Linoleic Acid (NPC85813) | NP level |
NCT02063802 | Metformin vs Conjugated Linoleic Acid and an Intervention Program With Healthy Habits in Obese Children | obesity | Linoleic Acid (NPC85813) | NP level |
NCT00584532 | Effects of a Genistein Concentrated Polysaccharide (GCP) for Prostate Cancer on Active Surveillance. | prostate cancer | Genistein (NPC39426) | NP level |
NCT00541710 | Effect of Genistein in Women With Metabolic Syndrome | metabolic syndrome | Genistein (NPC39426) | NP level |
NCT00287690 | Isoflavones and the Coronary Circulation in Men and Women With Coronary Artery Disease | coronary artery disease | Genistein (NPC39426) | NP level |
NCT01985763 | Genistein in Treatment of Metastatic Colorectal Cancer | colorectal carcinoma;malignant colon neoplasm;rectum cancer | Genistein (NPC39426) | NP level |
NCT02766478 | Genistein Supplementation to Mitigate Cardiometabolic Dysfunction in Patients Undergoing Androgen Deprivation Therapy for Prostate Cancer | prostate cancer | Genistein (NPC39426) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
AOX1,EGFR,ESRRB,CA12,ESR1,PPARA,ESRRA,CA4,NOS2
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
AKR1C3,MAOB,ESR2,AOX1,ESR1
NCT00584532,NCT00005827,NCT00058266,NCT02766478 |
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
BLM,CYP2C9,CA12,DPP4,ESRRA,CA4,FABP3,NOS2,FABP5
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
BLM,OR51E2,CA12,DPP4,CA4,FFAR1,FABP3,FABP5,CA7
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
ESR1,EGFR,CA12,CA4,ESR2
NCT00244933,NCT00908791,NCT00290758 |
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
BLM,OR51E2,CA4,ESR2,NOS2,FABP5,MAPT,LMNA
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
BLM,OR51E2,CA12,CA4,FABP3,NOS2,FABP5,FABP4
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
BLM,CYP2C9,OR51E2,TSHR,AKR1C3,CA7,NOS2,CA12
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
BLM,CA12,DPP4,TSHR,NOS2,FABP5,AOX1,LMNA
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
BLM,OR51E2,CA4,NOS2,FABP5,MAPT,NOS1
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
CYP2C9,FFAR4,FABP5,OR51E2,FFAR4,TSHR,FABP5
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
CYP2C9,ESRRB,ESR2,NOS2,ALOX15,NOS3,NOS1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
BLM,CYP2C9,CA12,TSHR,AKR1C3,CA7,NR1I2
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
CYP2C9,FFAR4,ESRRB,DPP4,ALOX15,FABP5,MAPT
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
OR51E2,FFAR4,ESRRB,DPP4,ESR1,NOS2,AOX1
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
OR51E2,FABP5,ALOX15
NCT01126879,NCT01325311,NCT00546039 |
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
NOS2,CA4,ESRRB,ESRRA
NCT00029679 |
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
ESRRA,DPP4,ESRRB
FABP5,NOS2 |
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
ESRRB,DPP4,CA4,FABP3,LMNA
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
ESRRB,FFAR1,NOS1,EGFR,LMNA
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
PPARA,DPP4,FFAR1
NCT00607945 |
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
NR1I2,FFAR1,FABP3,NOS2
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
DPP4,FFAR1,CA12,CA7
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
BLM,CYP2C9,ESRRB,ALOX15
|
Metabolic disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50-5D2Z |
DPP4
NCT00541710,NCT01664650 |
Vasomotor/allergic rhinitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA08 |
ESRRA,ESRRB,ESR2
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
DPP4,ESR1,PPARA
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CYP2C9,CA12,CA4
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
ESR2,MAPT,MAOB
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
FFAR1,PPARA,DPP4
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
NOS3,NOS3,MAOB
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
ESR1,ESR2,PPARA
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
EGFR
NCT01661764,NCT01985763 |
Non-small cell lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
EGFR
NCT02567799,NCT01628471 |
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
BLM,DPP4,TSHR
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
BLM,NOS2,ALOX15
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
ESRRB,FFAR1,NOS2
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
BLM,ESR1,CA12
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
ESRRA,ESRRB
|
Postoperative inflammationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-CA43 |
ESRRA,ESRRB
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
CA4,CA12
|
Contact dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EK00-EK0Z |
ESRRB,ESRRA
|
Female pelvic painDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA34 |
AKR1C3,ESR1
|
Menopausal disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA30 |
ESR2,ESR1
|
SepsisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1G40-1G41 |
ESR2,NOS2
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
ESR1,EGFR
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
EGFR,NOS3
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
NOS2,ESRRA
|
MigraineDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A80 |
MAOB,NOS1
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
NOS3,DPP4
|
Skin diseaseDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA00-EM0Z |
ESRRA,ESRRB
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
MAOB,MAPT
|
Eyelid inflammatory disorderDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A02 |
ESRRB,ESRRA
|
Hepatitis virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E50-1E51 |
EGFR,ESR2
|
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
PPARA
FABP4 |
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
ESR1
NCT00638196 |
Coronary atherosclerosisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA80 |
NOS2,NOS3
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
PPARA,NOS2
|
Inflammatory arthropathyDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA2Z |
ESRRB,ESRRA
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
NCT02063802,NCT00204932
|
Malignant neoplasm of pancreas, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.Z |
NCT00882765,NCT00376948
|
Cystic fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA25 |
NCT00016744,NCT00590538
|
Myelodysplastic syndromes, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A3Z |
CYP2C9,TSHR
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
BLM,ALOX15
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
AKR1C3,FABP4
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
ESRRB,CA4
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
AKR1C3,CA12
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
BLM,CYP2C9
|
Malignant neoplasms of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
FABP4,NOS2
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
ESRRA,CA12
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
BLM,AKR1C3
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
BLM,FFAR1,FABP3,FABP4,LMNA,OR51E2,PPARA,FABP5,AOX1,EGFR,TDP1,TSHR,NOS2,NR1I2,MAOB,ESR2,CA12,NOS3
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
FFAR4,ESRRB,DPP4,TDP1,TSHR,ALOX15,ESRRA,NR1I2,FFAR1,NOS2,FABP5,CA7,NOS1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
BLM,CYP2C9,OR51E2,FFAR4,DPP4,AKR1C3,NR1I2,MAOB,FABP3,NOS2,ALOX15,CA7,LMNA
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
CA12,FFAR4,ESRRB,TDP1,TSHR,ALOX15,ESRRA,NR1I2,ESR1,FABP3,FABP5,NOS1
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
BLM,OR51E2,CA12,AKR1C3,CA4,NOS2,FABP5,FABP4,MAPT,CA12,AKR1C3,MAPT
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
OR51E2,CA12,FFAR4,DPP4,TDP1,FFAR1,ALOX15,AOX1,CA7,EGFR,LMNA
|
Nasopharyngeal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6B |
EGFR
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
EGFR
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
EGFR
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
MAOB
|
DyspareuniaDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA12 |
ESR1
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
EGFR
|
OsteoarthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA00-FA05 |
NOS2
|
EndometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10 |
ESR1
|
Intracranial injuryDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NA07 |
NOS3
|
Muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70 |
MAOB
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
MAPT
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
EGFR
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1
|
Primary psychotic disorder manifestationDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A25 |
MAOB
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
DPP4
|
HypotensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA20-BA21 |
NOS3
|
Spinal cord/cranial nerve neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A02 |
EGFR
|
Skin cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30-2C37 |
MAOB
|
Colon cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90 |
EGFR
|
Adrenal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
ESR1
|
Skeletal anomalyDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD24 |
ESR1
|
VaginitisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA02 |
ESR1
|
Unspecific body region injuryDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: ND56 |
EGFR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOB
|
Metastatic tumourDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D50-2E2Z |
ESR1
|
Bowel habit changeDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME05 |
NOS2
|
IschemiaDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B10-8B11 |
EGFR
|
General pain disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E43 |
MAOB
|
Unspecified viral infection of unspecified siteDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D9Z |
ESR1
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
NOS2
|
Hypopharyngeal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6D |
EGFR
|
HyperlipidemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
PPARA
|
Male infertilityDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB04 |
ESR1
|
Diabetic foot ulcerDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD54 |
EGFR
|
Hypo-thyroidismDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A00 |
TSHR
|
Female genital tract noninflammatory disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA1Y |
ESR1
|
Chronic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30 |
EGFR
|
RetinopathyDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B71 |
NOS2
|
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
EGFR
|
Pituitary gland disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A60-5A61 |
ESR1
|
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
ESR2
|
Skin postprocedural disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EL8Y |
EGFR
|
Urethral cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C93 |
EGFR
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
DPP4
|
Testicular cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80 |
EGFR
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
MAPT
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
CA4
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
EGFR
|
Thyroid cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10 |
TSHR
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
EGFR
|
Insulin-resistance syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A44 |
NOS2
|
MelanomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
EGFR
|
Nausea/vomitingDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD90 |
MAOB
|
GoutDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA25 |
PPARA
|
Tension-type headacheDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A81 |
NOS1
|
Stomach cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
EGFR
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Breast in situ carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E65 |
ESR1
|
Metastatic lymph node neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60 |
EGFR
|
Idiopathic interstitial pneumonitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03 |
FFAR1
|
Prostate hyperplasiaDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA90 |
ESR2
|
MalariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F40-1F45 |
MAOB
|
Malignant mesenchymal neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B5D-2B5Y |
EGFR
|
Female infertilityDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA31 |
ESR1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
MAPT
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
ESRRA
|
Menstrual cycle bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20 |
ESR1
|
Low bone mass disorderDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB83 |
ESR1
|
Cushing syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A70 |
ESR2
|
Inborn lipid metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52 |
PPARA
|
Metastatic biliary tract neoplasmsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C14-2C17 |
EGFR
|
Autism spectrum disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A02 |
DPP4
|
Mature B-cell leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A82 |
EGFR
|
Skin tag/polypDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EK71 |
MAOB
|
Intracerebral haemorrhageDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B00 |
EGFR
|
DyslipidemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80-5C81 |
PPARA
|
Vitamin deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B55-5B5F |
AOX1
|
DepressionDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70-6A7Z |
MAOB
|
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
NOS2
|
Degenerative high myopiaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B76 |
ESRRA
|
OsteoporosisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB83.1 |
NCT00010686
|
Other specified non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92.Y |
NCT04853082
|
Rectum cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B92 |
NCT01985763
|
coronary artery diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA8Y-BA8Z |
NCT00287690
|
Malignant neoplasms of colonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90 |
NCT01985763
|
XerostomiaDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA02.1 |
NCT04392622
|
Severe acute respiratory syndromeDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D65 |
NCT04482595
|
Neoplasms of unknown behaviour of urinary organsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2F98 |
NCT00118040
|
Unspecified malignant neoplasms of unspecified sitesDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D4Z |
NCT00001696
|
Glioma, malignantDisease Category: X.Extension CodesDisease ICD-11 Code: XH4RQ3 |
NCT01792310
|
NeoplasmsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 02 |
NCT00951158
|
Malignant neoplasms of bladder, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.Z |
NCT01489813
|
Idiopathic pulmonary fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03.4 |
NCT04482595
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
NOS2
|
Coeliac diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA95 |
TSHR
|
Inflammatory bowel diseases, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD7Z |
NOS2
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
CA12
|
Dengue fever, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D2Z |
NR1I2
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
CA7
|
Intrauterine growth restrictionDisease Category: 19.Certain conditions originating in the perinatal periodDisease ICD-11 Code: KA20.1 |
NOS2
|
Malignant neoplasms of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
FABP4
|
KeratoconusDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A78.50 |
CA4
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
DPP4
|
Pre-eclampsiaDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA24 |
CA4
|
Pneumonia due to PseudomonasaeruginosaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA40.05 |
DPP4
|
Systemic sclerosisDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A42 |
FABP4
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
NOS2
|
Polycystic ovary syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80.1 |
FFAR4
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
FFAR1
|
Malignant neoplasm of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
FABP4
|