Collective Molecular Activities of the Plant: Ilex Latifolia
Plant ID: NPO10814
Plant Latin Name: Ilex Latifolia
Taxonomy Genus: Ilex
Taxonomy Family: Aquifoliaceae
Plant External Links:
NCBI TaxonomyDB:
53205
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
47 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
10 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
11 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC9498
Ingredient ID: NPC90096
Ingredient ID: NPC836
Ingredient ID: NPC78894
Ingredient ID: NPC7645
Ingredient ID: NPC74418
Ingredient ID: NPC68464
Ingredient ID: NPC62307
Ingredient ID: NPC57954
Ingredient ID: NPC5728
Ingredient ID: NPC5290
Ingredient ID: NPC41518
Ingredient ID: NPC312971
Ingredient ID: NPC307122
Ingredient ID: NPC295387
Ingredient ID: NPC294438
Ingredient ID: NPC292238
Ingredient ID: NPC287207
Ingredient ID: NPC273134
Ingredient ID: NPC272713
Ingredient ID: NPC271974
Ingredient ID: NPC267691
Ingredient ID: NPC265800
Ingredient ID: NPC261096
Ingredient ID: NPC251681
Ingredient ID: NPC248222
Ingredient ID: NPC247312
Ingredient ID: NPC244940
Ingredient ID: NPC241909
Ingredient ID: NPC225240
Ingredient ID: NPC213832
Ingredient ID: NPC213645
Ingredient ID: NPC195514
Ingredient ID: NPC189224
Ingredient ID: NPC181092
Ingredient ID: NPC179215
Ingredient ID: NPC175467
Ingredient ID: NPC16712
Ingredient ID: NPC160415
Ingredient ID: NPC146563
Ingredient ID: NPC14319
Ingredient ID: NPC136923
Ingredient ID: NPC135061
Ingredient ID: NPC133984
Ingredient ID: NPC129854
Ingredient ID: NPC12455
Ingredient ID: NPC110676
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Surface antigen | F3 | Coagulation factor III | P13726 | CHEMBL4081 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials |
|---|
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
F3
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
F3
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F3
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
F3
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
F3
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
F3
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
F3
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
F3
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
