Collective Molecular Activities of the Plant: Bletilla Striata
Country/Region:
ChinaTraditional Medicine System:
TCMMedicinal Functions:
Antibacterial; Antiinflammatory; Antiphlogistic; Demulcent; Pectoral; Skin; Styptic; Vulnerary
Japan; China; Myanmar; South Africa
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
75 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
37 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
44 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC96998
Ingredient ID: NPC96835
Ingredient ID: NPC8564
Ingredient ID: NPC66367
Ingredient ID: NPC64847
Ingredient ID: NPC58963
Ingredient ID: NPC53906
Ingredient ID: NPC52271
Ingredient ID: NPC480637
Ingredient ID: NPC480636
Ingredient ID: NPC480635
Ingredient ID: NPC480634
Ingredient ID: NPC480633
Ingredient ID: NPC480632
Ingredient ID: NPC478415
Ingredient ID: NPC472649
Ingredient ID: NPC472648
Ingredient ID: NPC472647
Ingredient ID: NPC472646
Ingredient ID: NPC4300
Ingredient ID: NPC37410
Ingredient ID: NPC36269
Ingredient ID: NPC35340
Ingredient ID: NPC344
Ingredient ID: NPC32357
Ingredient ID: NPC317727
Ingredient ID: NPC31342
Ingredient ID: NPC312929
Ingredient ID: NPC309588
Ingredient ID: NPC300161
Ingredient ID: NPC294436
Ingredient ID: NPC288702
Ingredient ID: NPC282690
Ingredient ID: NPC282508
Ingredient ID: NPC276682
Ingredient ID: NPC264381
Ingredient ID: NPC263572
Ingredient ID: NPC258780
Ingredient ID: NPC258492
Ingredient ID: NPC254819
Ingredient ID: NPC254433
Ingredient ID: NPC254000
Ingredient ID: NPC253622
Ingredient ID: NPC246588
Ingredient ID: NPC236569
Ingredient ID: NPC232525
Ingredient ID: NPC231373
Ingredient ID: NPC228503
Ingredient ID: NPC227509
Ingredient ID: NPC22610
Ingredient ID: NPC224340
Ingredient ID: NPC217922
Ingredient ID: NPC214502
Ingredient ID: NPC206525
Ingredient ID: NPC191462
Ingredient ID: NPC185147
Ingredient ID: NPC183709
Ingredient ID: NPC181427
Ingredient ID: NPC176152
Ingredient ID: NPC171739
Ingredient ID: NPC169968
Ingredient ID: NPC165273
Ingredient ID: NPC159966
Ingredient ID: NPC159773
Ingredient ID: NPC148699
Ingredient ID: NPC148599
Ingredient ID: NPC136699
Ingredient ID: NPC133463
Ingredient ID: NPC126291
Ingredient ID: NPC120247
Ingredient ID: NPC113495
Ingredient ID: NPC111891
Ingredient ID: NPC108198
Ingredient ID: NPC103110
Ingredient ID: NPC100551
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Methyl-lysine/arginine binding protein | L3MBTL1 | Lethal(3)malignant brain tumor-like protein 1 | Q9Y468 | CHEMBL1287622 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 138 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT02213575 | Study 3: Minocycline Decreases Microglia Activation | hypertension | Minocycline (NPC317727) | NP level |
| NCT04031755 | A Proof-of-Concept Study of Minocycline in Autism | autism | Minocycline (NPC317727) | NP level |
| NCT00733057 | Minocycline for the Treatment of Early-Phase Schizophrenia | neurobehavioral manifestations | Minocycline (NPC317727) | NP level |
| NCT00361257 | Minocycline for the Treatment of Decreased Mental Function in HIV-Infected Adults | HIV infection | Minocycline (NPC317727) | NP level |
| NCT01906008 | Phase II Study of Minocycline for Reducing Symptom Burden in Colorectal Patients | colorectal carcinoma | Minocycline (NPC317727) | NP level |
| NCT02113176 | Minocycline as Neuroprotectant After Aneurysmal Subarachnoid Hemorrhage | hemorrhage | Minocycline (NPC317727) | NP level |
| NCT02099240 | Patients Response to Early Switch To Oral:Osteomyelitis Study | osteomyelitis | Minocycline (NPC317727) | NP level |
| NCT00536042 | Open-Label Trial of the Use of Minocycline in the Treatment of Asthma | asthma | Minocycline (NPC317727) | NP level |
| NCT00501059 | A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease | cardiovascular disease | Salicylic Acid (NPC100551) | NP level |
| NCT01805895 | A Pilot Study of Minocycline in Intracerebral Hemorrhage Patients | intracerebral hemorrhage | Minocycline (NPC317727) | NP level |
| NCT02289768 | Study To Evaluate The Efficacy And Safety Of Actikerall® Solution In Patients With Grade I-II Actinic Keratoses | actinic keratosis | Salicylic Acid (NPC100551) | NP level |
| NCT01580969 | Repeat Radiation, Minocycline and Bevacizumab in Patients With Recurrent Glioma | central nervous system cancer | Minocycline (NPC317727) | NP level |
| NCT00916461 | Role of Minocycline in First Episode Psychosis | psychosis | Minocycline (NPC317727) | NP level |
| NCT02533232 | Minocycline Augmentation of Clozapine for Treatment Resistant Schizophrenia | schizoaffective disorder;schizophrenia | Minocycline (NPC317727) | NP level |
| NCT01134627 | Minocycline as add-on to Interferon Beta-1a [IFN Beta-1a] (Rebif®) in Relapsing-Remitting Multiple Sclerosis [RRMS] | relapsing-remitting multiple sclerosis | Minocycline (NPC317727) | NP level |
| NCT03947827 | Minocycline as Adjunctive Treatment for Treatment Resistant Depression | treatment resistant depression | Minocycline (NPC317727) | NP level |
| NCT01139749 | Efficacy and Safety of Low-dose Oral Isotretinoin for Seborrhea | seborrheic dermatitis | Salicylic Acid (NPC100551) | NP level |
| NCT02815280 | A Study to Compare the Efficacy and Safety of Topical Administration of FMX-101 for Treatment of Moderate-to-Severe Acne | acne | Minocycline (NPC317727) | NP level |
| NCT00203112 | Safety and Efficacy Study of Copaxone Administered in Combination With Minocycline | multiple sclerosis | Minocycline (NPC317727) | NP level |
| NCT01809340 | The Effect of Minocycline on Relapse After Successful Intravenous Ketamine/Minocycline-induced Symptoms Response in Subjects With Depression | depressive disorder | Minocycline (NPC317727) | NP level |
| NCT01706250 | U0289-401: Eight Week, Split-face, Study to Determine and Compare the Efficacy and Tolerability of MAXCLARITY™ II to PROACTIV™ | acne | Salicylic Acid (NPC100551) | NP level |
| NCT02770378 | A Proof-of-concept Clinical Trial Assessing the Safety of the Coordinated Undermining of Survival Paths by 9 Repurposed Drugs Combined With Metronomic Temozolomide (CUSP9v3 Treatment Protocol) for Recurrent Glioblastoma | glioblastoma multiforme | Minocycline (NPC317727) | NP level |
| NCT01552798 | Efficacy of a Single Dose of Aspirin vs. Acetaminophen in Tension Type Headache | Headache | Salicylic Acid (NPC100551) | NP level |
| NCT00401921 | A Study of the Effects of Minocycline on Cognitive Function After Carotid Endarterectomy | internal carotid artery stenosis | Minocycline (NPC317727) | NP level |
| NCT02703363 | Minocycline and Celecoxib as Adjunctive Treatments of Bipolar Depression | bipolar disorder;depressive disorder | Minocycline (NPC317727) | NP level |
| NCT00371332 | Effect of Adjunctive Treatment With Arestin on the Subgingival Microflora in Patients With Moderate to Advanced Periodontitis | periodontitis | Minocycline (NPC317727) | NP level |
| NCT00063193 | National Institute of Neurological Disorders and Stroke (NINDS) Parkinson's Disease Neuroprotection Trial | Parkinson disease | Minocycline (NPC317727) | NP level |
| NCT02193269 | The Effects of Minocycline in Humans | memory impairment | Minocycline (NPC317727) | NP level |
| NCT00277355 | Pilot Study of Minocycline in Huntington's Disease | Huntington disease | Minocycline (NPC317727) | NP level |
| NCT03056703 | Bioequivalence of Single Dose Fast Release Aspirin (1000 mg) Tablet Versus Single Dose of Two 500 mg Fast Release Aspirin Tablets | pain | Salicylic Acid (NPC100551) | NP level |
| NCT02313909 | Rivaroxaban Versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With Recent Embolic Stroke of Undetermined Source (ESUS) | stroke | Salicylic Acid (NPC100551) | NP level |
| NCT00029874 | Minocycline in Patients With Huntington's Disease | Huntington disease | Minocycline (NPC317727) | NP level |
| NCT00145106 | Comparison of Tazarotene and Minocycline Therapies for Maintenance of Facial Acne Vulgaris | acne | Minocycline (NPC317727) | NP level |
| NCT00630396 | Study of a Neuroprotective Drug to Limit the Extent of Damage From an Ischemic Stroke | stroke | Minocycline (NPC317727) | NP level |
| NCT02055963 | Minocycline for Postsurgical Symptom Reduction in Head and Neck Cancer | head and neck malignant neoplasia | Minocycline (NPC317727) | NP level |
| NCT01938508 | Minocycline Bioequivalence Study | skin disease | Minocycline (NPC317727) | NP level |
| NCT02569307 | Minocycline and/or Omega-3 Fatty Acids Added to Treatment as Usual for At Risk Mental States | psychosis | Minocycline (NPC317727) | NP level |
| NCT01693523 | Minocycline Study in Pancreatic Cancer Patients | pancreatic carcinoma | Minocycline (NPC317727) | NP level |
| NCT05032781 | Intra-Arterial Neuroprotective Agents and Cold Saline in Ischemic Stroke Intervention | stroke | Minocycline (NPC317727) | NP level |
| NCT01219673 | Symptom Burden in Head and Neck Cancer | head and neck malignant neoplasia | Minocycline (NPC317727) | NP level |
| NCT01706263 | U0289-402: An Open Label, 8 Week Study to Evaluate the Efficacy and Tolerability of MAXCLARITY II in Subjects With Acne | acne | Salicylic Acid (NPC100551) | NP level |
| NCT01914627 | Parallel Group Trial to Evaluate the Efficacy and Safety of Loion® Compared to 10% Salicylic Acid in Patients With Chronic Psoriasis Capitis | psoriasis | Salicylic Acid (NPC100551) | NP level |
| NCT01083420 | The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus | oral lichen planus | Minocycline (NPC317727) | NP level |
| NCT01828203 | Minocycline in Acute Spinal Cord Injury (MASC) | Spinal cord injury | Minocycline (NPC317727) | NP level |
| NCT00501254 | Pharmacodynamic Trial, of Slow Release ASA, in Platelet Functionalism, a Long Term Treatment Period | cardiovascular disease | Salicylic Acid (NPC100551) | NP level |
| NCT03447925 | Treatment of Plantar Keratosis With Medicinal Plant in Diabetic Patients | keratosis | Salicylic Acid (NPC100551) | NP level |
| NCT02812719 | Treatment of Melasma With Glycolic Acid-Salicylic Acid Peel Versus Glycolic Acid Peel | freckles | Salicylic Acid (NPC100551) | NP level |
| NCT01574742 | Open Study Assessing the Feasibility of Minocycline in Patients With Unipolar Depression | unipolar depression | Minocycline (NPC317727) | NP level |
| NCT02178813 | The Safety of High Dose Minocycline in the Patient Population Undergoing Carotid Revascularization | stroke | Minocycline (NPC317727) | NP level |
| NCT02187211 | Minocycline's Effects on Alcohol Responses in Humans | alcohol dependence | Minocycline (NPC317727) | NP level |
| NCT02695446 | Administration of Oral Extended Release Minocycline for Assessment of Skin and Plasma Concentrations of Minocycline | acne | Minocycline (NPC317727) | NP level |
| NCT01403662 | Evaluating the Efficacy of Adjunctive Minocycline for the Treatment of Bipolar Depression | bipolar disorder;depressive disorder | Minocycline (NPC317727) | NP level |
| NCT01746043 | A Phase II Study of Minocycline and Armodafinil for Reducing the Symptom Burden Produced by Chemoradiation Treatment for Esophageal Cancer | esophageal cancer | Minocycline (NPC317727) | NP level |
| NCT01755611 | Bioequivalence Minocycline Bioequivalence | infection | Minocycline (NPC317727) | NP level |
| NCT02250859 | A Pharmacokinetic Study of Minocycline in Male and Female Volunteers | acne | Minocycline (NPC317727) | NP level |
| NCT00666887 | Minocycline in Clinically Isolated Syndromes (CIS) | multiple sclerosis | Minocycline (NPC317727) | NP level |
| NCT03117530 | Measuring Brain Inflammation in Autism | autism spectrum disorder | Minocycline (NPC317727) | NP level |
| NCT01012349 | Efficacy and Safety Clinical Trial of the Combination of Acetylsalicylic Acid, Sodium Bicarbonate and Citric Acid, Produced by Geolab Pharmaceutical Industries Ltd., Compared to Acetylsalicylic Acid (Aspirin ® - Bayer) in Patients With Episodic Tension-type Headache. | Tension-type headache | Salicylic Acid (NPC100551) | NP level |
| NCT01539564 | Arestin - Use in Subjects With Peri-Implantitis | Peri-Implantitis | Minocycline (NPC317727) | NP level |
| NCT01429272 | Minocycline and Aspirin in the Treatment of Bipolar Depression | bipolar disorder | Minocycline (NPC317727) | NP level |
| NCT01517334 | Arestin - Use in Subjects With Peri-Implantitis (With Subgingival Microbiological Evaluation) | Peri-Implantitis | Minocycline (NPC317727) | NP level |
| NCT01422148 | Minocycline Plus Amiodarone Versus Amiodarone Alone for the Prevention of Atrial Fibrillation After Cardiac Surgery | atrial fibrillation | Minocycline (NPC317727) | NP level |
| NCT00361322 | Efficacy and Safety of a Preparation Containing an Antibiotic and Anti-Inflammatory Agent in Acne Vulgaris | acne | Salicylic Acid (NPC100551) | NP level |
| NCT01048983 | Reducing Symptom Burden - Non Small Cell Lung Cancer (NSCLC) | non-small cell lung carcinoma | Minocycline (NPC317727) | NP level |
| NCT02564978 | Evaluation of Oral Minocycline in the Treatment of Geographic Atrophy Associated With Age-Related Macular Degeneration | age-related macular degeneration | Minocycline (NPC317727) | NP level |
| NCT00240513 | Study Comparing Acne in Patients Taking Oral Minocycline to Patients Taking Minocycline Plus Topical Tretinoin | acne | Minocycline (NPC317727) | NP level |
| NCT03414502 | Treatment of Rheumatoid Arthritis With DMARDs: Predictors of Response | rheumatoid arthritis | Minocycline (NPC317727) | NP level |
| NCT00559494 | Minocycline and Perfusion Pressure Augmentation in Acute Spinal Cord Injury | Spinal cord injury | Minocycline (NPC317727) | NP level |
| NCT01206348 | Combination Treatment for Moderate to Severe Acne | acne | Minocycline (NPC317727) | NP level |
| NCT02907437 | Minocycline add-on to Antipsychotics for the Treatment of Negative and Cognitive Symptoms in Schizophrenia | schizophrenia | Minocycline (NPC317727) | NP level |
| NCT01173692 | Minocycline for Reduction of Radiation Therapy Treatment-Related Symptom Burden in Oropharynx Cancer: A Randomized Study. | oropharynx cancer | Minocycline (NPC317727) | NP level |
| NCT02056665 | Study to Evaluate the Efficacy and Safety of Minocycline in Angelman Syndrome | Angelman syndrome | Minocycline (NPC317727) | NP level |
| NCT00988026 | Safety and Efficacy Comparison of Minocycline Microgranules Versus Lymecycline in the Treatment of Mild to Moderate Acne | acne | Minocycline (NPC317727) | NP level |
| NCT01793051 | Intervention for Symptom Burden During Maintenance Therapy for Multiple Myeloma | multiple myeloma | Minocycline (NPC317727) | NP level |
| NCT04594733 | The Effect of Minocycline and N-acetylcysteine for the Treatment of Fibromyalgia | fibromyalgia | Minocycline (NPC317727) | NP level |
| NCT00047723 | Minocycline to Treat Amyotrophic Lateral Sclerosis | amyotrophic lateral sclerosis | Minocycline (NPC317727) | NP level |
| NCT01294462 | Study to Assess Safety and Efficacy of Ticagrelor (AZD6140) Versus Clopidogrel in Asian/Japanese Patients With Non-ST or ST Elevation Acute Coronary Syndromes (ACS) | acute coronary syndrome | Salicylic Acid (NPC100551) | NP level |
| NCT00662532 | Antibiotic Study for Dental Implants | periodontitis | Minocycline (NPC317727) | NP level |
| NCT02928965 | The Benefit of Minocycline on Negative Symptoms in Schizophrenia: Extent and Mechanisms | schizophrenia | Minocycline (NPC317727) | NP level |
| NCT03263273 | Study to Evaluate the Safety and Efficacy of Topical Minocycline Gel in Patients With Papulopustular Rosacea | rosacea | Minocycline (NPC317727) | NP level |
| NCT02680379 | Combined Treatment of Minocycline and Lovastatin to Treat Individuals With Fragile X Syndrome | fragile X syndrome | Minocycline (NPC317727) | NP level |
| NCT02755545 | A Clinical Trial to Evaluate the Efficacy of Two Acne Treatments | acne | Salicylic Acid (NPC100551) | NP level |
| NCT04490967 | Silymarin Cream Versus Salicylic Acid in Treatment of Acne Vulgaris | acne | Salicylic Acid (NPC100551) | NP level |
| NCT01058395 | Safety and Feasibility of Minocycline in the Treatment of Traumatic Brain Injury (TBI) | brain injury | Minocycline (NPC317727) | NP level |
| NCT04068207 | Minocycline Treatment in Retinitis Pigmentosa | retinitis pigmentosa | Minocycline (NPC317727) | NP level |
| NCT01228656 | Effectiveness of Association Mometasone Furoate 0.1% and Salicylic Acid 5% Compared With Mometasone Furoate | psoriasis | Salicylic Acid (NPC100551) | NP level |
| NCT03320018 | Neuroprotection in Acute Ischemic Stroke | stroke | Minocycline (NPC317727) | NP level |
| NCT04608500 | A Study (Study 2) to Evaluate the Safety and Efficacy of FMX103 1.5% Topical Minocycline Foam in the Treatment of Facial Papulopustular Rosacea | rosacea | Minocycline (NPC317727) | NP level |
| NCT03489629 | STaph Aureus Resistance-Treat Early and Repeat (STAR-TER) | cystic fibrosis | Minocycline (NPC317727) | NP level |
| NCT05474950 | Minocycline Treatment for Cystoid Macular Edema | cystoid macular edema | Minocycline (NPC317727) | NP level |
| NCT00456677 | Evaluation of the Utility of Minocycline as an Anti-Inflammatory Agent in the Treatment of Asthma | asthma | Minocycline (NPC317727) | NP level |
| NCT03503227 | The Value of Prednisolone With Aspirin Before Embryo Transfer in Intracytoplasmic Sperm Injection (ICSI) Cycles | infertility | Salicylic Acid (NPC100551) | NP level |
| NCT00579644 | Treatment of Early RA: Minocycline in Combination With Methotrexate vs Methotrexate Alone | rheumatoid arthritis | Minocycline (NPC317727) | NP level |
| NCT02541500 | An Open Label Study of Oral Minocycline for the Treatment of Patients With Co-occurring Opioid and ATS Dependence | heroin dependence | Minocycline (NPC317727) | NP level |
| NCT00355576 | Combination Therapy Selection Trial in Amyotrophic Lateral Sclerosis | amyotrophic lateral sclerosis | Minocycline (NPC317727) | NP level |
| NCT03142451 | A Study (Study 1) to Evaluate the Safety and Efficacy of FMX103 1.5% Topical Minocycline Foam in the Treatment of Facial Papulopustular Rosacea | rosacea | Minocycline (NPC317727) | NP level |
| NCT02524665 | 8 Week Study to Evaluate and Compare the Efficacy and Tolerability of MAXCLARITY II and MURAD To Treat Acne | acne | Salicylic Acid (NPC100551) | NP level |
| NCT03040128 | Use of Minocycline in Intracerebral Hemorrhage | intracerebral hemorrhage | Minocycline (NPC317727) | NP level |
| NCT00203697 | Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot Study | idiopathic pulmonary fibrosis | Minocycline (NPC317727) | NP level |
| NCT00425074 | Pharmacodynamic-pharmacokinetic Trial, of Slow Release ASA, in the Platelet Functionalism. | cardiovascular disease | Salicylic Acid (NPC100551) | NP level |
| NCT02060149 | The Effect of Nebulization of Alkaline Solution on Treating XDRAB Pneumonia With C/S Plus Minocycline | pneumonia | Minocycline (NPC317727) | NP level |
| NCT01695291 | Novel Medication Strategies Targeting Brain Mechanisms in Pediatric OCD | obsessive-compulsive disorder | Minocycline (NPC317727) | NP level |
| NCT04291456 | Minocycline in MS: Confirmation of Benefit | multiple sclerosis | Minocycline (NPC317727) | NP level |
| NCT02362529 | Biomarkers of Neuroinflammation and Anti-Inflammatory Treatments in Major Depressive Disorder | major depressive disorder | Minocycline (NPC317727) | NP level |
| NCT01362218 | Pharmacodynamic Clinical Trial of Cardiovascular Polypill on LDL Cholesterol | Hypercholesterolemia | Salicylic Acid (NPC100551) | NP level |
| NCT03832647 | Anti-acne Efficacy of a Dermo-cosmetic Product Associated With the Fixed Combination Adapalene 0.1%/ Benzoyl Peroxide 2.5% Treatment Versus This Treatment Associated With a Standard Moisturizer in Male and Female Subjects Presenting With Mild to Moderate Acne | acne | Salicylic Acid (NPC100551) | NP level |
| NCT01314482 | Minocycline for the Prevention of Post-operative Intercostal Neuralgia | neuralgia | Minocycline (NPC317727) | NP level |
| NCT02815267 | A Study to Compare the Efficacy and Safety of Topical Administration of FMX-101 for Treatment of Moderate-to-Severe Acne | acne | Minocycline (NPC317727) | NP level |
| NCT01134991 | Study to Evaluate the Safety and Efficacy of Topical Minocycline FXFM244 in Rosacea Patients | rosacea | Minocycline (NPC317727) | NP level |
| NCT00392223 | Efficacy And Safety Of Azithromycin SR Compared With Minocycline In Acne | acne | Minocycline (NPC317727) | NP level |
| NCT02947763 | Single Versus Multiple Visits Endodontic Treatment | Periapical Periodontitis | Minocycline (NPC317727) | NP level |
| NCT01362010 | Clinical Study to Evaluate Tolerability and Safety of FXFM244 and to Monitor Clinical Effect in Acne Vulgaris Patients | acne | Minocycline (NPC317727) | NP level |
| NCT02133885 | Study 2: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients | hypertension | Minocycline (NPC317727) | NP level |
| NCT01468844 | Minocycline to Treat Central Retinal Vein Occlusion | retinal vein occlusion | Minocycline (NPC317727) | NP level |
| NCT01171326 | Study to Evaluate the Safety and Efficacy of Topical Minocycline FXFM244 in Impetigo Patients | impetigo | Minocycline (NPC317727) | NP level |
| NCT01297816 | Evaluation of Neuroprotective Effect of Minocycline | retinal detachment | Minocycline (NPC317727) | NP level |
| NCT02815332 | BPX-01 Minocycline Topical Gel in the Treatment of Acne Vulgaris | acne | Minocycline (NPC317727) | NP level |
| NCT01468831 | Minocycline to Treat Branch Retinal Vein Occlusion | retinal vein occlusion | Minocycline (NPC317727) | NP level |
| NCT02946788 | Open Label Photo-Documentation Study Of BPX-01 Minocycline Gel | acne | Minocycline (NPC317727) | NP level |
| NCT03050086 | Open Label Phase 2 Feasibility Study of BPX-04 Topical Minocycline Gel in Rosacea | rosacea | Minocycline (NPC317727) | NP level |
| NCT02998151 | Neurophysiological and Acute Pharmacological Studies in FXS Patients | fragile X syndrome | Minocycline (NPC317727) | NP level |
| NCT00630942 | Minocycline in Primary Sclerosing Cholangitis (PSC) | sclerosing cholangitis | Minocycline (NPC317727) | NP level |
| NCT02352987 | Effect of Neem Extract, Propylene Glycol and Salicylic Acid Combination in the Treatment of Arsenical Palmar Keratosis | heavy metal poisoning | Salicylic Acid (NPC100551) | NP level |
| NCT01283997 | Prevention of Treatment Induced Neuropathy in Multiple Myeloma | multiple myeloma | Minocycline (NPC317727) | NP level |
| NCT01004705 | A Pharmacodynamic Study to Evaluate the Effect of a Fixed Dose Combination Pill on Low Density Lipoprotein (LDL) Cholesterol | Hypercholesterolemia | Salicylic Acid (NPC100551) | NP level |
| NCT02051296 | Minocycline to Reduce Pain After Carpal Tunnel Release | Chronic pain | Minocycline (NPC317727) | NP level |
| NCT01320982 | Minocycline, Acetylsalicylic Acid or Pramipexole vs Placebo in Patients With Schizophrenia or Schizoaffective Disorder | schizoaffective disorder;schizophrenia | Minocycline (NPC317727) | NP level |
| NCT02456948 | Adjunct Minocyline in Treatment-resistant Depression | major depressive disorder | Minocycline (NPC317727) | NP level |
| NCT04478500 | Neuroinflammation in Hypertension Study | hypertension | Minocycline (NPC317727) | NP level |
| NCT03369951 | Minocycline Pharmacokinetics (ACUMIN) | bacterial disease | Minocycline (NPC317727) | NP level |
| NCT02272270 | Phase I Newly Diagnosed GBM With Temozolomide, Radiation, and Minocycline Followed by Adjuvant Minocycline/Temozolomide (D-TERMINED) | malignant glioma | Minocycline (NPC317727) | NP level |
| NCT00515255 | Study of NPL-2003 in Adolescents With Obsessive Compulsive Disorder (OCD) | obsessive-compulsive disorder | Minocycline (NPC317727) | NP level |
| NCT01046942 | ThrombElastoGraphic Haemostatic Status and Antiplatelet Therapy After Coronary Artery Bypass Graft Surgery | thrombophilia;thrombotic disease | Salicylic Acid (NPC100551) | NP level |
| NCT01453400 | Evaluate the Time of Pain Relief of Fast Acting Aspirin Versus Acetaminophen in Subjects Diagnosed With Sore Throat Pain | pharyngitis | Salicylic Acid (NPC100551) | NP level |
| NCT00154895 | Additional Minocycline Pleurodesis After Thoracoscopic Procedures for Primary Spontaneous Pneumothorax | Pneumothorax | Minocycline (NPC317727) | NP level |
| NCT01636934 | Minocycline Study in Non Small Cell Lung Cancer (NSCLC) Patients for Chemoradiation Therapy | lung cancer | Minocycline (NPC317727) | NP level |
| NCT01229085 | Efficacy Study of the Combination Mometasone + Salicylic Acid in Patients With Psoriasis | psoriasis | Salicylic Acid (NPC100551) | NP level |
| NCT02140164 | Study of Oral Minocycline in Treating Bilateral Cystoid Macular Edema Associated With Retinitis Pigmentosa | retinitis pigmentosa | Minocycline (NPC317727) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Ischaemic/haemorrhagic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B20 |
NCT02313909,NCT05032781,NCT03320018,NCT00630396,NCT02178813
|
RosaceaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED90 |
NCT03050086,NCT01134991,NCT04608500,NCT03142451,NCT03263273
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
NCT02533232,NCT01320982,NCT02907437,NCT02928965
|
Bipolar disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60 |
NCT01429272,NCT02703363,NCT01403662
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
NCT01229085,NCT01228656,NCT01914627
|
Depressive disorders, unspecifiedDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A7Z |
NCT02703363,NCT01403662,NCT01809340
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
NCT00203112,NCT04291456,NCT00666887
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
NCT00425074,NCT00501059,NCT00501254
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
NCT02133885,NCT04478500,NCT02213575
|
Intracerebral haemorrhageDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B00 |
NCT01805895,NCT03040128
|
Injury of spinal cord, level unspecifiedDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: ND51.2 |
NCT00559494,NCT01828203
|
Amyotrophic lateral sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B60.0 |
NCT00355576,NCT00047723
|
Single episode depressive disorder, severe, without psychotic symptomsDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70.3 |
NCT02456948,NCT02362529
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
NCT00536042,NCT00456677
|
Obsessive-compulsive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B20 |
NCT00515255,NCT01695291
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
NCT03414502,NCT00579644
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
NCT02055963,NCT01219673
|
Neuropathy, ataxia, and retinitis pigmentosaDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C73.1 |
NCT04068207,NCT02140164
|
Schizophrenia or other primary psychotic disorders, unspecifiedDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A2Z |
NCT02569307,NCT00916461
|
HypercholesterolaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80.0 |
NCT01362218,NCT01004705
|
NADisease Category: NADisease ICD-11 Code: NA |
NCT01539564,NCT01517334
|
Periodontal diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA0C |
NCT00371332,NCT00662532
|
Schizoaffective disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A21 |
NCT01320982,NCT02533232
|
DepressionDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70-6A7Z |
NCT03947827,NCT01574742
|
Tension-type headacheDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A81 |
NCT01012349,NCT01552798
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
NCT01283997,NCT01793051
|
Huntington diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01.10 |
NCT00029874,NCT00277355
|
Retinal vascular occlusionDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B74 |
NCT01468831,NCT01468844
|
Autism spectrum disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A02 |
NCT03117530,NCT04031755
|
Fragile X chromosomeDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD55 |
NCT02680379,NCT02998151
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
NCT01706263,NCT00392223,NCT02946788,NCT02815332,NCT00240513,NCT00988026,NCT01206348,NCT02524665,NCT02815280,NCT01362010,NCT00145106,NCT02755545,NCT03832647,NCT00361322,NCT02695446,NCT02815267,NCT02250859,NCT04490967,NCT01706250
|
Thyroid cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10 |
TSHR
|
Hypo-thyroidismDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A00 |
TSHR
|
PneumoniaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA40 |
NCT02060149
|
Asymptomatic stenosis of intracranial or extracranial arteryDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD55 |
NCT00401921
|
Malignant neoplasms of oropharynxDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6A |
NCT01173692
|
Central nervous system diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A04-8D87 |
NCT01580969
|
Male infertilityDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB04 |
NCT03503227
|
Chronic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30 |
NCT02051296
|
Harmful effects of drugs, medicaments or biological substances, not elsewhere classifiedDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE60 |
NCT02352987
|
Macular degenerationDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B75 |
NCT02564978
|
Actinic keratosisDisease Category: X.Extension CodesDisease ICD-11 Code: XH36H6 |
NCT02289768
|
NasopharyngitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA00 |
NCT01453400
|
Skin diseaseDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA00-EM0Z |
NCT01938508
|
Haemorrhage, not elsewhere classifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG27 |
NCT02113176
|
Other specified disorders of the retinaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B7Y |
NCT05474950
|
Cystic fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA25 |
NCT03489629
|
Alcohol dependenceDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40.2 |
NCT02187211
|
FrecklesDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED61.0 |
NCT02812719
|
Deep vein thrombosisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD71 |
NCT01046942
|
Opioid dependence, unspecifiedDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C43.2Z |
NCT02541500
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
NCT03369951
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT01294462
|
ImpetigoDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1B72 |
NCT01171326
|
Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62.Z |
NCT00361257
|
Angelman syndromeDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD90.0 |
NCT02056665
|
Primary sclerosing cholangitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB96.2 |
NCT00630942
|
Age-associated cognitive declineDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB21.0 |
NCT02193269
|
Periapical periodontitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA09.7 |
NCT02947763
|
Herpes simplex infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F00 |
NCT01755611
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
NCT00063193
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
NCT01422148
|
Glioma, malignantDisease Category: X.Extension CodesDisease ICD-11 Code: XH4RQ3 |
NCT02272270
|
Osteomyelitis or osteitisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB84 |
NCT02099240
|
PneumothoraxDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB21 |
NCT00154895
|
Non-small cell lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
NCT01048983
|
ThrombophiliaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B61 |
NCT01046942
|
Chronic neuropathic pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30.5Z |
NCT01314482
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
NCT01139749
|
Glioblastoma, primary, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH0MB1 |
NCT02770378
|
Idiopathic pulmonary fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03.4 |
NCT00203697
|
Malignant neoplasm of pancreas, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.Z |
NCT01693523
|
Relapsing-remitting multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40.0 |
NCT01134627
|
Lichen planusDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA91 |
NCT01083420
|
Keratosis pilarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED56 |
NCT03447925
|
Chronic widespread painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30.01 |
NCT04594733
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
NCT01906008
|
Retinal detachmentDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B73 |
NCT01297816
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
NCT01636934
|
Intracranial injury, unspecifiedDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NA07.Z |
NCT01058395
|
Esophageal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
NCT01746043
|
Neurobehavioral disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00-8A0Z |
NCT00733057
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
NCT03056703
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
TSHR
|
Coeliac diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA95 |
TSHR
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
TSHR
|
Myelodysplastic syndromes, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A3Z |
TSHR
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
L3MBTL1
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
L3MBTL1
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
TSHR
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
TSHR
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
TSHR
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
NAPRT
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
TSHR
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
L3MBTL1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
TSHR
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
TSHR
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
