Collective Molecular Activities of the Plant: Prunus Dulcis
Plant ID: NPO10029
Plant Latin Name: Prunus Dulcis
Taxonomy Genus: Prunus
Taxonomy Family: Rosaceae
Plant External Links:
NCBI TaxonomyDB:
3755
Plant-of-the-World-Online:
n.a.
Country/Region:
India; ItalyTraditional Medicine System:
Unani; Indian Folk; Homeopathy; Ayurveda; SiddhaMedicinal Functions:
Antiemetic; Antitumor; Demulcent; Emollient; Miscellany; Nutritive; Pectoral
Italy; India
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
125 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
78 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
99 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99734
Ingredient ID: NPC94167
Ingredient ID: NPC93888
Ingredient ID: NPC85813
Ingredient ID: NPC85488
Ingredient ID: NPC83032
Ingredient ID: NPC79943
Ingredient ID: NPC78500
Ingredient ID: NPC78263
Ingredient ID: NPC68779
Ingredient ID: NPC65678
Ingredient ID: NPC62045
Ingredient ID: NPC60151
Ingredient ID: NPC59650
Ingredient ID: NPC55412
Ingredient ID: NPC491218
Ingredient ID: NPC490427
Ingredient ID: NPC490424
Ingredient ID: NPC489910
Ingredient ID: NPC489908
Ingredient ID: NPC489907
Ingredient ID: NPC489899
Ingredient ID: NPC48623
Ingredient ID: NPC44659
Ingredient ID: NPC424
Ingredient ID: NPC40511
Ingredient ID: NPC39426
Ingredient ID: NPC36061
Ingredient ID: NPC34089
Ingredient ID: NPC330817
Ingredient ID: NPC328447
Ingredient ID: NPC32817
Ingredient ID: NPC32441
Ingredient ID: NPC31714
Ingredient ID: NPC317120
Ingredient ID: NPC314434
Ingredient ID: NPC313955
Ingredient ID: NPC309330
Ingredient ID: NPC30506
Ingredient ID: NPC301585
Ingredient ID: NPC29883
Ingredient ID: NPC295644
Ingredient ID: NPC294852
Ingredient ID: NPC294548
Ingredient ID: NPC290319
Ingredient ID: NPC281686
Ingredient ID: NPC281131
Ingredient ID: NPC272614
Ingredient ID: NPC269980
Ingredient ID: NPC269919
Ingredient ID: NPC265885
Ingredient ID: NPC265319
Ingredient ID: NPC26484
Ingredient ID: NPC261831
Ingredient ID: NPC260491
Ingredient ID: NPC257582
Ingredient ID: NPC251354
Ingredient ID: NPC246558
Ingredient ID: NPC246534
Ingredient ID: NPC243319
Ingredient ID: NPC242580
Ingredient ID: NPC237812
Ingredient ID: NPC230301
Ingredient ID: NPC228346
Ingredient ID: NPC226453
Ingredient ID: NPC226340
Ingredient ID: NPC226027
Ingredient ID: NPC220825
Ingredient ID: NPC219876
Ingredient ID: NPC219143
Ingredient ID: NPC216630
Ingredient ID: NPC213876
Ingredient ID: NPC209970
Ingredient ID: NPC208793
Ingredient ID: NPC20791
Ingredient ID: NPC20535
Ingredient ID: NPC203468
Ingredient ID: NPC203050
Ingredient ID: NPC201844
Ingredient ID: NPC201284
Ingredient ID: NPC199072
Ingredient ID: NPC196745
Ingredient ID: NPC189436
Ingredient ID: NPC188428
Ingredient ID: NPC187770
Ingredient ID: NPC185755
Ingredient ID: NPC181465
Ingredient ID: NPC179950
Ingredient ID: NPC17810
Ingredient ID: NPC176740
Ingredient ID: NPC176017
Ingredient ID: NPC174246
Ingredient ID: NPC174020
Ingredient ID: NPC171736
Ingredient ID: NPC1682
Ingredient ID: NPC167400
Ingredient ID: NPC163099
Ingredient ID: NPC163076
Ingredient ID: NPC162806
Ingredient ID: NPC162742
Ingredient ID: NPC156654
Ingredient ID: NPC15566
Ingredient ID: NPC155263
Ingredient ID: NPC152451
Ingredient ID: NPC150950
Ingredient ID: NPC149803
Ingredient ID: NPC149184
Ingredient ID: NPC147983
Ingredient ID: NPC137958
Ingredient ID: NPC136014
Ingredient ID: NPC135602
Ingredient ID: NPC133671
Ingredient ID: NPC130683
Ingredient ID: NPC126681
Ingredient ID: NPC126029
Ingredient ID: NPC125062
Ingredient ID: NPC120649
Ingredient ID: NPC116775
Ingredient ID: NPC11433
Ingredient ID: NPC113733
Ingredient ID: NPC112890
Ingredient ID: NPC111888
Ingredient ID: NPC111132
Ingredient ID: NPC104983
Ingredient ID: NPC104316
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2B6 | Cytochrome P450 2B6 | P20813 | CHEMBL4729 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A3 | Dopamine transporter | Q01959 | CHEMBL238 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A2 | Norepinephrine transporter | P23975 | CHEMBL222 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A4 | Serotonin transporter | P31645 | CHEMBL228 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 626 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000114 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000116 | Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Ascorbate (NPC187770);Beta Carotene (NPC17810) | NP level |
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
| NCT00000372 | Glycine and D-Cycloserine in Schizophrenia | schizophrenia | Glycine (NPC126681) | NP level |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | Myocardial Ischemia | Beta Carotene (NPC17810);Folic Acid (NPC147983);Pyridoxine (NPC269919) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
NCT00694564
|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1
NCT03090048,NCT03522922 |
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR,MAOB
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
DPP4,NR3C1,AURKB,FFAR1,PPARA,KDR
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TP53,PIM1,FLT3,MAPT,AURKB,AXL,SRC,KDM1A,NFKB1
NCT00184054,NCT00329498,NCT01842139 |
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT02929888
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
