Access Plants That Show Activities on Each Target Protein

Target Class L1 Target Class L2 Target Class L3 Target Gene Symbol Target Name No. of Plants No. of Medicinal Plants No. of Food Plants No. of Human Edible Plants No. of Agricultural Plants No. of Garden Plants No. of Drug-producing Plants
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 RORB Nuclear receptor ROR-beta 2 1 0 1 0 0 0
Epigenetic regulator Eraser Lysine demethylase KDM4E Lysine-specific demethylase 4D-like 649 287 72 199 0 18 145
Enzyme Kinase Protein Kinase SGK1 Serine/threonine-protein kinase Sgk1 1 0 0 1 0 0 1
Membrane receptor Family C G protein-coupled receptor Small molecule receptor (family C GPCR) GRM8 Metabotropic glutamate receptor 8 142 111 127 25 0 8 22
Unclassified protein n.a. n.a. MEN1 Menin 1 1 0 1 0 0 1
Enzyme Transferase n.a. PIK3CD PI3-kinase p110-delta subunit 1 0 0 0 0 0 0
Enzyme Kinase Protein Kinase PLK4 Serine/threonine-protein kinase PLK4 2 0 0 2 0 0 1
Enzyme Kinase Protein Kinase STK25 Serine/threonine-protein kinase 25 1 0 0 1 0 0 1
Enzyme Hydrolase n.a. FAAH Anandamide amidohydrolase 11 8 4 4 0 1 0
Enzyme Hydrolase n.a. CES2 Carboxylesterase 2 40 18 0 4 0 0 7
Enzyme n.a. n.a. SCD Acyl-CoA desaturase 11 6 0 5 0 1 1
Enzyme Kinase Protein Kinase CIT Citron Rho-interacting kinase 1 0 0 1 0 0 1
Enzyme Isomerase n.a. PTGES Prostaglandin E synthase 55 40 5 24 0 3 9
Enzyme Kinase Protein Kinase MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 3 2 0 3 0 0 1
Enzyme Transferase n.a. TERT Telomerase reverse transcriptase 22 15 3 9 0 0 6
Enzyme Kinase Protein Kinase CHEK1 Serine/threonine-protein kinase Chk1 15 9 0 4 0 1 4
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) FFAR1 Free fatty acid receptor 1 549 288 141 166 1 17 139
Enzyme Kinase Protein Kinase IKBKB Inhibitor of nuclear factor kappa B kinase beta subunit 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase AURKA Serine/threonine-protein kinase Aurora-A 38 25 6 16 0 0 6
Enzyme Kinase Protein Kinase GAK Serine/threonine-protein kinase GAK 3 1 0 2 0 0 1
Enzyme Kinase Protein Kinase DCLK1 Serine/threonine-protein kinase DCLK1 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase CHUK Inhibitor of nuclear factor kappa B kinase alpha subunit 1 0 0 1 0 0 1
Transporter n.a. n.a. NPC1 Niemann-Pick C1 protein 152 51 10 39 0 2 54
Enzyme Kinase Protein Kinase MUSK Muscle, skeletal receptor tyrosine protein kinase 1 0 0 1 0 0 1
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22A2 Solute carrier family 22 member 2 5 3 1 1 0 1 0
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22A1 Solute carrier family 22 member 1 3 1 0 1 0 0 0
Enzyme Kinase Protein Kinase MAPK13 MAP kinase p38 delta 1 0 0 1 0 0 1
Epigenetic regulator Eraser Histone deacetylase HDAC3 Histone deacetylase 3 1 0 0 0 0 0 0
Enzyme Kinase Protein Kinase PDPK1 3-phosphoinositide dependent protein kinase-1 2 0 0 2 0 0 1
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) MLNR Motilin receptor 1 1 1 0 0 0 0
Enzyme Kinase Protein Kinase DAPK3 Death-associated protein kinase 3 2 0 0 2 0 0 1
Enzyme Kinase Protein Kinase MAP3K7 Mitogen-activated protein kinase kinase kinase 7 3 2 0 3 0 0 1
Enzyme Kinase Protein Kinase RIPK2 Serine/threonine-protein kinase RIPK2 3 1 0 2 0 0 1
Enzyme Hydrolase n.a. MGAM Maltase-glucoamylase 10 6 2 4 0 0 1
Enzyme Lyase n.a. CA12 Carbonic anhydrase XII 2498 986 175 700 3 66 589
Enzyme Kinase Protein Kinase DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 6 3 0 5 0 0 1
Enzyme Oxidoreductase n.a. AKR1B10 Aldo-keto reductase family 1 member B10 245 103 15 85 0 7 69
Enzyme Kinase Protein Kinase NUAK1 NUAK family SNF1-like kinase 1 295 115 23 94 0 5 71
Enzyme Kinase Protein Kinase JAK2 Tyrosine-protein kinase JAK2 10 5 0 4 0 0 2
Transcription factor n.a. n.a. MITF Microphthalmia-associated transcription factor 8 5 1 2 0 0 0
Enzyme Kinase Protein Kinase ROCK2 Rho-associated protein kinase 2 8 3 0 3 0 0 2
Enzyme Kinase Protein Kinase ULK1 Serine/threonine-protein kinase ULK1 1 0 0 1 0 0 1
Enzyme n.a. n.a. ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 1 0 0 1 0 0 1
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 NR1I2 Pregnane X receptor 11 8 1 5 0 1 2
Unclassified protein n.a. n.a. GMNN Geminin 64 36 5 16 0 5 20
Enzyme Kinase Protein Kinase RPS6KA5 Ribosomal protein S6 kinase alpha 5 1 0 0 1 0 0 1
Enzyme Protease Cysteine protease USP2 Ubiquitin carboxyl-terminal hydrolase 2 39 27 5 21 0 2 12
Enzyme Kinase Protein Kinase RPS6KA4 Ribosomal protein S6 kinase alpha 4 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase STK16 Serine/threonine-protein kinase 16 1 0 0 1 0 0 1
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22A3 Solute carrier family 22 member 3 16 6 0 3 0 0 2
Ion channel Voltage-gated ion channel Transient receptor potential channel TRPA1 Transient receptor potential cation channel subfamily A member 1 200 93 22 52 0 3 32
Enzyme Kinase Protein Kinase PAK3 Serine/threonine-protein kinase PAK 3 1 0 0 1 0 0 1
Enzyme Phosphodiesterase Phosphodiesterase 5 PDE5A Phosphodiesterase 5A 11 9 0 6 0 0 0
Enzyme Phosphodiesterase Phosphodiesterase 9 PDE9A Phosphodiesterase 9A 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase STK17B Serine/threonine-protein kinase 17B 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase STK10 Serine/threonine-protein kinase 10 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase PRKD3 Protein kinase C nu 2 0 0 2 0 0 1
Transporter Electrochemical transporter SLC superfamily of solute carriers SLCO2B1 Solute carrier organic anion transporter family member 2B1 2 2 0 2 0 0 1
Enzyme Transferase n.a. TNKS Tankyrase-1 49 28 6 17 1 2 7
Transporter Primary active transporter ATP-binding cassette ABCB11 Bile salt export pump 9 7 3 3 0 0 4
Enzyme Kinase Protein Kinase MAP3K6 Mitogen-activated protein kinase kinase kinase 6 1 0 0 1 0 0 1
Enzyme Phosphodiesterase n.a. TDP2 Tyrosyl-DNA phosphodiesterase 2 14 11 0 4 0 1 2
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 ESRRB Estrogen-related receptor beta 166 96 47 45 1 8 16
Enzyme Kinase Protein Kinase MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 9 3 0 4 0 0 2
Enzyme Kinase Protein Kinase LATS1 Serine/threonine-protein kinase LATS1 1 0 0 1 0 0 1
Enzyme Hydrolase n.a. ABHD16A Protein BAT5 3 3 1 2 0 1 0
Enzyme Kinase Protein Kinase PAK4 Serine/threonine-protein kinase PAK 4 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase CHEK2 Serine/threonine-protein kinase Chk2 6 1 0 3 0 0 2
Enzyme Oxidoreductase n.a. ALDH1A1 Aldehyde dehydrogenase 1A1 244 85 15 69 0 9 53
Enzyme Oxidoreductase n.a. DHFR Dihydrofolate reductase 1 0 0 0 0 0 0
Transporter Primary active transporter Oxidoreduction-driven transporters COX2 Cytochrome c oxidase subunit 2 14 7 2 3 0 0 9
Enzyme Kinase Protein Kinase ABL1 Tyrosine-protein kinase ABL 4 2 0 2 0 0 2
Enzyme Kinase Protein Kinase EGFR Epidermal growth factor receptor erbB1 312 125 23 100 0 5 72
Enzyme Protease Serine protease F2 Thrombin 93 41 9 32 0 4 17
Enzyme Protease Serine protease F10 Coagulation factor X 153 53 6 49 0 5 37
Enzyme Protease Aspartic protease REN Renin 1 1 0 0 0 0 0
Enzyme Hydrolase n.a. ADA Adenosine deaminase 8 5 1 3 0 0 4
Enzyme Lyase n.a. CA1 Carbonic anhydrase I 243 97 13 75 0 4 57
Enzyme Lyase n.a. CA2 Carbonic anhydrase II 1492 618 144 423 1 35 357
Other cytosolic protein n.a. n.a. HRAS Transforming protein p21/H-Ras-1 1 0 0 1 0 0 0
Secreted protein n.a. n.a. TNF TNF-alpha 1 1 0 1 0 0 0
Structural protein n.a. n.a. LMNA Prelamin-A/C 2393 1053 229 661 3 54 567
Secreted protein n.a. n.a. TTR Transthyretin 691 287 58 204 0 18 193
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 ESR1 Estrogen receptor alpha 521 255 110 133 1 13 88
Enzyme Oxidoreductase n.a. ND4 NADH-ubiquinone oxidoreductase chain 4 26 15 1 3 0 0 3
Enzyme Protease Metallo protease MMP1 Matrix metalloproteinase-1 439 271 106 137 0 19 115
Enzyme Oxidoreductase n.a. HMGCR HMG-CoA reductase 1 1 1 0 0 0 1
Enzyme Kinase Protein Kinase RAF1 Serine/threonine-protein kinase RAF 4 2 0 2 0 0 2
Enzyme Hydrolase n.a. FUCA1 Alpha-L-fucosidase I 2 1 1 0 0 0 0
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 NR3C1 Glucocorticoid receptor 117 46 10 32 0 1 31
Surface antigen n.a. n.a. PRNP Prion protein 2 1 0 0 0 0 0
Enzyme Transferase n.a. TK1 Thymidine kinase, cytosolic 76 30 8 20 0 2 16
Secreted protein n.a. n.a. SHBG Testis-specific androgen-binding protein 12 9 2 6 0 0 0
Enzyme Kinase Protein Kinase ERBB2 Receptor protein-tyrosine kinase erbB-2 3 1 0 2 0 0 1
Enzyme Kinase Protein Kinase NTRK1 Nerve growth factor receptor Trk-A 1 0 0 1 0 0 1
Transcription factor n.a. n.a. TP53 Cellular tumor antigen p53 330 196 52 106 1 14 99
Enzyme Cytochrome P450 Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 2032 794 165 550 1 47 509
Transporter Primary active transporter P-type ATPase ATP1A1 Sodium/potassium-transporting ATPase alpha-1 chain 15 9 1 7 0 1 5
Membrane receptor n.a. n.a. APP Beta amyloid A4 protein 300 196 155 84 0 10 80
Enzyme Oxidoreductase n.a. ALDH2 Aldehyde dehydrogenase 41 24 5 15 0 1 6
Enzyme Cytochrome P450 Cytochrome P450 family 17 CYP17A1 Cytochrome P450 17A1 2 1 0 1 0 0 0
Secreted protein n.a. n.a. SERPINE1 Plasminogen activator inhibitor-1 1 1 0 1 0 1 0
Enzyme Kinase Protein Kinase PRKCG Protein kinase C gamma 13 7 0 9 0 1 7
Enzyme Oxidoreductase n.a. MPO Myeloperoxidase 27 13 5 5 0 2 8
Enzyme Cytochrome P450 Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 2002 784 159 539 1 44 499
Enzyme n.a. n.a. ALPL Alkaline phosphatase, tissue-nonspecific isozyme 521 209 49 154 0 14 116
Transcription factor n.a. n.a. JUN Proto-oncogene c-JUN 6 5 0 0 0 0 6
Enzyme Kinase Protein Kinase PRKCB Protein kinase C beta 12 7 0 8 0 1 7
Enzyme Protease Serine protease HPN Serine protease hepsin 1 1 0 0 0 0 1
Enzyme Kinase Protein Kinase INSR Insulin receptor 296 115 23 95 0 5 71
Enzyme Kinase Protein Kinase LCK Tyrosine-protein kinase LCK 30 17 3 7 0 0 4
Enzyme Kinase Protein Kinase FYN Tyrosine-protein kinase FYN 41 26 7 14 0 1 2
Enzyme Hydrolase n.a. BCHE Butyrylcholinesterase 22 15 2 5 0 1 1
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 PGR Progesterone receptor 33 22 3 12 0 1 10
Enzyme Kinase Protein Kinase CDK1 Cyclin-dependent kinase 1 1333 555 133 392 0 35 304
Enzyme n.a. n.a. PYGL Liver glycogen phosphorylase 5 2 1 1 0 0 0
Enzyme n.a. n.a. POLB DNA polymerase beta 1587 666 156 463 0 41 364
Enzyme Hydrolase n.a. LPL Lipoprotein lipase 3 3 1 2 0 1 0
Enzyme Protease Serine protease EPHX1 Epoxide hydrolase 1 1 1 1 1 0 0 0
Enzyme Isomerase n.a. P4HB Protein disulfide-isomerase 58 15 2 17 0 1 17
Enzyme Kinase Protein Kinase FES Tyrosine-protein kinase FES 2 0 0 2 0 0 1
Enzyme Kinase Protein Kinase CSF1R Macrophage colony stimulating factor receptor 7 4 1 4 0 0 2
Enzyme Protease Aspartic protease CTSD Cathepsin D 1 0 0 0 0 0 0
Enzyme Protease Cysteine protease CAPN1 Calpain 1 20 5 0 1 0 0 11
Enzyme Lyase n.a. CA3 Carbonic anhydrase III 13 6 2 2 0 0 0
Enzyme Protease Serine protease PRSS1 Trypsin I 1 1 0 1 0 1 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADRB2 Beta-2 adrenergic receptor 22 8 3 4 0 2 5
Enzyme Protease Cysteine protease CTSL Cathepsin L 2 1 0 0 0 0 1
Enzyme Protease Cysteine protease CTSB Cathepsin B 6 4 1 2 0 0 2
Other cytosolic protein n.a. n.a. HSP90AA1 Heat shock protein HSP 90-alpha 27 8 0 4 0 0 12
Enzyme Kinase Protein Kinase YES1 Tyrosine-protein kinase YES 1324 552 132 391 0 35 304
Enzyme Kinase Protein Kinase LYN Tyrosine-protein kinase Lyn 3 1 0 2 0 0 1
Enzyme Kinase Protein Kinase RET Tyrosine-protein kinase receptor RET 12 5 0 5 0 0 3
Enzyme Kinase Protein Kinase IGF1R Insulin-like growth factor I receptor 1485 610 140 429 0 38 359
Transcription factor n.a. n.a. GLI1 Zinc finger protein GLI1 36 7 2 11 0 1 13
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) CHRM2 Muscarinic acetylcholine receptor M2 35 26 6 10 0 1 16
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) CHRM4 Muscarinic acetylcholine receptor M4 23 17 5 8 0 1 6
Transporter Primary active transporter ATP-binding cassette ABCB1 P-glycoprotein 1 153 62 11 46 0 6 40
Secreted protein n.a. n.a. SERPINA6 Corticosteroid binding globulin 39 21 5 13 0 1 10
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 NR3C2 Mineralocorticoid receptor 28 19 2 11 0 1 10
Other cytosolic protein n.a. n.a. HSP90AB1 Heat shock protein HSP 90-beta 1 1 0 1 0 0 0
Enzyme Protease Metallo protease MMP2 Matrix metalloproteinase-2 508 293 109 164 0 20 135
Enzyme Protease Metallo protease MMP3 Matrix metalloproteinase 3 6 1 0 1 0 0 4
Enzyme Kinase Protein Kinase MET Hepatocyte growth factor receptor 1454 600 140 426 0 37 345
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADRB1 Beta-1 adrenergic receptor 25 10 3 6 0 2 5
Enzyme Kinase Protein Kinase HCK Tyrosine-protein kinase HCK 13 6 0 5 0 0 3
Enzyme Cytochrome P450 Cytochrome P450 family 3 CYP3A4 Cytochrome P450 3A4 544 278 150 143 0 14 99
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR1A Serotonin 1a (5-HT1a) receptor 125 65 22 34 0 9 30
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) CHRM5 Muscarinic acetylcholine receptor M5 33 26 6 10 0 1 16
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADRA2A Alpha-2a adrenergic receptor 100 52 8 27 0 3 34
Enzyme Kinase Protein Kinase ROS1 Proto-oncogene tyrosine-protein kinase ROS 8 3 0 3 0 0 2
Enzyme Transferase n.a. GSTP1 Glutathione S-transferase Pi 271 167 143 57 0 10 60
Enzyme Kinase Protein Kinase PDGFRB Platelet-derived growth factor receptor beta 4 2 0 2 0 0 2
Enzyme Kinase Protein Kinase FGR Tyrosine-protein kinase FGR 1 0 0 1 0 0 1
Enzyme Transferase n.a. POLA1 DNA polymerase alpha subunit 8 5 1 4 0 0 1
Enzyme Oxidoreductase n.a. ALOX5 Arachidonate 5-lipoxygenase 154 75 10 42 0 5 27
Enzyme Protease Metallo protease LTA4H Leukotriene A4 hydrolase 1 1 0 1 0 1 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADORA3 Adenosine A3 receptor 221 117 14 77 0 4 55
Other cytosolic protein n.a. n.a. HSPA1A Heat shock 70 kDa protein 1 294 115 23 93 0 5 70
Transcription factor n.a. n.a. GLI2 Zinc finger protein GLI2 10 6 2 1 0 0 1
Secreted protein n.a. n.a. CXCL8 Interleukin-8 18 10 3 6 0 0 13
Enzyme Hydrolase n.a. GAA Lysosomal alpha-glucosidase 21 11 4 9 0 0 10
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 AR Androgen Receptor 49 28 6 16 0 1 14
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 RARA Retinoic acid receptor alpha 3 1 0 2 0 0 0
Ion channel Other ion channel Miscellaneous ion channel BCL2 Apoptosis regulator Bcl-2 254 102 25 74 0 9 50
Enzyme Cytochrome P450 Cytochrome P450 family 2 CYP2C8 Cytochrome P450 2C8 1 1 0 1 0 0 0
Enzyme Cytochrome P450 Cytochrome P450 family 2 CYP2D6 Cytochrome P450 2D6 179 106 5 43 0 2 65
Other cytosolic protein n.a. n.a. MAPT Microtubule-associated protein tau 187 107 23 55 0 8 35
Enzyme Kinase Protein Kinase KIT Stem cell growth factor receptor 11 4 0 3 0 0 5
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 RARB Retinoic acid receptor beta 2 1 0 1 0 0 0
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 THRA Thyroid hormone receptor alpha 1 0 0 0 0 0 0
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 THRB Thyroid hormone receptor beta-1 113 55 12 36 0 9 31
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC2A1 Glucose transporter 26 7 1 3 0 0 12
Enzyme n.a. n.a. UMPS Uridine 5'-monophosphate synthase 3 2 0 2 0 0 1
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) CHRM1 Muscarinic acetylcholine receptor M1 34 27 6 10 0 1 16
Other cytosolic protein n.a. n.a. BCR Bcr/Abl fusion protein 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase PIM1 Serine/threonine-protein kinase PIM1 1374 573 135 402 0 38 315
Enzyme Kinase Protein Kinase FGFR1 Fibroblast growth factor receptor 1 12 5 0 5 0 0 3
Enzyme Isomerase n.a. TOP1 DNA topoisomerase I 28 19 0 12 0 1 8
Enzyme Isomerase n.a. TOP2A DNA topoisomerase II alpha 405 179 71 113 0 13 89
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 VDR Vitamin D receptor 2 1 0 0 0 0 0
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 ESRRA Estrogen-related receptor alpha 166 96 47 45 1 8 16
Enzyme Cytochrome P450 Cytochrome P450 family 2 CYP2A6 Cytochrome P450 2A6 86 33 6 26 1 1 38
Enzyme Cytochrome P450 Cytochrome P450 family 19 CYP19A1 Cytochrome P450 19A1 496 185 41 144 0 11 112
Enzyme Cytochrome P450 Cytochrome P450 family 2 CYP2C9 Cytochrome P450 2C9 243 118 22 68 0 5 55
Enzyme Kinase Protein Kinase CDK4 Cyclin-dependent kinase 4 1 0 0 0 0 0 0
Enzyme Oxidoreductase n.a. IMPDH2 Inosine-5'-monophosphate dehydrogenase 2 1 0 0 0 0 0 0
Enzyme Protease Metallo protease ACE Angiotensin-converting enzyme 2 2 0 1 0 0 0
Enzyme Kinase Protein Kinase SRC Tyrosine-protein kinase SRC 333 128 24 99 0 6 86
Enzyme Protease Metallo protease PEPD Xaa-Pro dipeptidase 7 2 0 2 0 1 0
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 RARG Retinoic acid receptor gamma 2 1 0 1 0 0 0
Surface antigen n.a. n.a. F3 Coagulation factor III 726 309 46 210 0 19 160
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC5A1 Sodium/glucose cotransporter 1 61 20 9 13 0 2 13
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADRB3 Beta-3 adrenergic receptor 29 14 4 8 0 2 5
Enzyme Oxidoreductase n.a. HSD17B1 Estradiol 17-beta-dehydrogenase 1 752 307 62 221 0 20 206
Enzyme Protease Aspartic protease CTSE Cathepsin E 1 0 0 0 0 0 0
Enzyme n.a. n.a. MIF Macrophage migration inhibitory factor 61 26 10 21 0 2 7
Enzyme Transferase n.a. FDPS Farnesyl diphosphate synthase 1 1 1 0 0 1 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) DRD2 Dopamine D2 receptor 124 72 26 31 0 6 29
Enzyme Kinase Protein Kinase INSRR Insulin receptor-related protein 1 0 0 1 0 0 1
Enzyme n.a. n.a. PKM Pyruvate kinase isozymes M1/M2 14 13 4 7 0 1 1
Enzyme Oxidoreductase n.a. TYR Tyrosinase 15 14 3 9 0 0 1
Enzyme Protease Metallo protease MMP9 Matrix metalloproteinase 9 483 284 108 153 0 21 128
Ion channel Ligand-gated ion channel GABA-A receptor GABRA1 GABA receptor alpha-1 subunit 3 2 1 1 0 0 1
Enzyme Oxidoreductase n.a. IDO1 Indoleamine 2,3-dioxygenase 8 8 1 3 0 2 0
Enzyme Oxidoreductase n.a. DAO D-amino-acid oxidase 4 4 3 0 0 1 2
Enzyme Kinase Protein Kinase BRAF Serine/threonine-protein kinase B-raf 4 2 0 2 0 0 2
Enzyme Protease Metallo protease CPA1 Carboxypeptidase A1 4 2 0 2 0 0 0
Enzyme Protease Metallo protease CPB1 Carboxypeptidase B 1 0 0 1 0 0 0
Auxiliary transport protein Fatty acid binding protein family n.a. FABP4 Fatty acid binding protein adipocyte 510 278 55 186 0 19 134
Enzyme Oxidoreductase n.a. AKR1B1 Aldose reductase 487 212 39 153 0 6 124
Enzyme n.a. n.a. HPGD 15-hydroxyprostaglandin dehydrogenase [NAD+] 295 116 23 94 0 5 70
Enzyme Cytochrome P450 Cytochrome P450 family 11 CYP11B1 Cytochrome P450 11B1 1 0 0 0 0 0 0
Enzyme Oxidoreductase n.a. NQO1 Quinone reductase 1) 4 4 2 0 0 1 0
Enzyme Kinase Protein Kinase PHKG2 Phosphorylase kinase gamma subunit 2 2 0 0 2 0 0 1
Enzyme Oxidoreductase n.a. ALOX15 Arachidonate 15-lipoxygenase 695 365 155 210 1 19 176
Enzyme Oxidoreductase n.a. NQO2 Quinone reductase 2 149 68 12 41 0 1 27
Enzyme Oxidoreductase n.a. CBR1 Carbonyl reductase [NADPH] 1 166 59 5 45 0 3 42
Enzyme Hydrolase n.a. PNLIP Pancreatic lipase 3 3 1 2 0 1 0
Enzyme Kinase Protein Kinase PDGFRA Platelet-derived growth factor receptor alpha 4 2 0 2 0 0 2
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) TSHR Thyroid stimulating hormone receptor 597 384 127 188 0 17 149
Enzyme Kinase Protein Kinase FER Tyrosine-protein kinase FER 2 0 0 2 0 0 1
Enzyme Kinase Protein Kinase PRKCA Protein kinase C alpha 77 27 2 21 0 1 23
Enzyme Kinase Protein Kinase PRKACA cAMP-dependent protein kinase alpha-catalytic subunit 1 0 0 1 0 0 1
Enzyme Phosphatase Protein Phosphatase PTPN2 T-cell protein-tyrosine phosphatase 19 4 0 2 0 0 9
Unclassified protein n.a. n.a. XBP1 X-box-binding protein 1 19 4 0 1 0 0 10
Enzyme Kinase Protein Kinase FLT1 Vascular endothelial growth factor receptor 1 12 5 0 5 0 0 3
Enzyme Phosphatase Protein Phosphatase PTPN1 Protein-tyrosine phosphatase 1B 22 9 1 11 0 1 5
Enzyme n.a. n.a. ALOX12 Arachidonate 12-lipoxygenase 1396 580 134 414 0 36 319
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADRA2B Alpha-2b adrenergic receptor 275 200 173 70 0 13 57
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADRA2C Alpha-2c adrenergic receptor 70 40 7 21 0 0 19
Enzyme Cytochrome P450 Cytochrome P450 family 11 CYP11B2 Cytochrome P450 11B2 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 2 0 0 1 0 0 1
Enzyme Kinase Protein Kinase CSNK2A2 Casein kinase II alpha (prime) 1 0 0 1 0 0 1
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 2 RXRA Retinoid X receptor alpha 4 2 1 1 0 0 0
Transcription factor n.a. n.a. NFKB1 Nuclear factor NF-kappa-B p105 subunit 1166 541 184 334 1 31 297
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) CHRM3 Muscarinic acetylcholine receptor M3 39 32 7 10 0 1 21
Enzyme Protease Threonine protease PSMB1 Proteasome component C5 132 56 4 43 0 2 23
Membrane receptor n.a. n.a. ITGAL Leukocyte adhesion glycoprotein LFA-1 alpha 25 15 3 10 0 2 5
Enzyme Kinase Protein Kinase MAK Serine/threonine-protein kinase MAK 1 0 0 1 0 0 1
Enzyme Cytochrome P450 Cytochrome P450 family 2 CYP2B6 Cytochrome P450 2B6 67 57 63 5 0 5 17
Enzyme Cytochrome P450 Cytochrome P450 family 3 CYP3A5 Cytochrome P450 3A5 2 2 1 0 0 0 2
Enzyme Oxidoreductase n.a. IMPDH1 Inosine-5'-monophosphate dehydrogenase 1 1 0 0 0 0 0 0
Enzyme Oxidoreductase n.a. MAOA Monoamine oxidase A 396 184 21 128 0 6 113
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) CNR1 Cannabinoid CB1 receptor 95 30 4 28 0 2 33
Enzyme Kinase Protein Kinase EPHA1 Ephrin type-A receptor 1 1 0 0 1 0 0 1
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) DRD1 Dopamine D1 receptor 686 308 79 202 0 13 168
Enzyme Kinase Protein Kinase FGFR2 Fibroblast growth factor receptor 2 1 0 0 1 0 0 1
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) DRD4 Dopamine D4 receptor 49 35 15 14 0 1 15
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) DRD5 Dopamine D5 receptor 124 63 17 38 0 2 32
Ion channel Voltage-gated ion channel Potassium channels KCNA3 Voltage-gated potassium channel subunit Kv1.3 43 7 0 12 0 1 9
Enzyme Hydrolase n.a. ACHE Acetylcholinesterase 1850 754 146 509 0 45 445
Enzyme Transferase n.a. UGT1A1 UDP-glucuronosyltransferase 1-1 6 5 1 3 0 0 0
Enzyme Kinase Protein Kinase FGFR4 Fibroblast growth factor receptor 4 2 1 0 2 0 0 1
Enzyme Kinase Protein Kinase FGFR3 Fibroblast growth factor receptor 3 2 0 0 2 0 0 1
Enzyme Kinase Protein Kinase PRKACB cAMP-dependent protein kinase beta-1 catalytic subunit 1 0 0 1 0 0 1
Enzyme Lyase n.a. CA4 Carbonic anhydrase IV 1540 630 128 459 2 42 350
Enzyme n.a. n.a. CES1 Acyl coenzyme A:cholesterol acyltransferase 1356 483 59 352 0 29 332
Enzyme Oxidoreductase n.a. PTGS1 Cyclooxygenase-1 144 62 12 38 0 3 39
Enzyme Lyase n.a. CA6 Carbonic anhydrase VI 105 47 12 26 0 3 23
Ion channel Ligand-gated ion channel Glycine receptor GLRA1 Glycine receptor subunit alpha-1 6 3 1 2 0 1 0
Enzyme Kinase Protein Kinase RPS6KB1 Ribosomal protein S6 kinase 1 2 0 0 2 0 0 1
Enzyme Kinase Protein Kinase JAK1 Tyrosine-protein kinase JAK1 2 1 0 1 0 0 1
Enzyme Hydrolase n.a. AHCY Adenosylhomocysteinase 1 1 0 1 0 0 0
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC6A2 Norepinephrine transporter 78 66 71 8 0 5 16
Ion channel Ligand-gated ion channel GABA-A receptor GABRR1 GABA receptor rho-1 subunit 57 33 5 19 0 4 19
Enzyme Cytochrome P450 Cytochrome P450 family 5 TBXAS1 Thromboxane-A synthase 26 15 4 6 0 0 9
Enzyme Kinase Protein Kinase PRKCH Protein kinase C eta 3 2 0 3 0 1 2
Enzyme Kinase Protein Kinase CDK2 Cyclin-dependent kinase 2 10 3 1 3 0 0 1
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) CXCR1 Interleukin-8 receptor A 1 1 1 0 0 0 1
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADRA1D Alpha-1d adrenergic receptor 86 32 6 27 0 3 25
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) PTAFR Platelet activating factor receptor 3 3 1 2 0 1 0
Epigenetic regulator Writer DNA methyltransferase DNMT1 DNA (cytosine-5)-methyltransferase 1 101 43 9 32 0 5 21
Enzyme Oxidoreductase n.a. MAOB Monoamine oxidase B 297 115 15 82 0 5 62
Enzyme Kinase Protein Kinase MAPK3 MAP kinase ERK1 3 2 0 1 0 0 1
Enzyme Kinase Protein Kinase MARK3 Serine/threonine-protein kinase c-TAK1 9 3 0 4 0 0 2
Enzyme Protease Serine protease DPP4 Dipeptidyl peptidase IV 1269 561 139 367 2 34 298
Enzyme n.a. n.a. APEX1 DNA-(apurinic or apyrimidinic site) lyase 706 311 92 211 0 20 156
Enzyme Phosphodiesterase Phosphodiesterase 4 PDE4A Phosphodiesterase 4A 1 1 0 1 0 0 0
Enzyme Protease Threonine protease PSMB5 Proteasome Macropain subunit MB1 202 84 23 61 0 9 40
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR1D Serotonin 1d (5-HT1d) receptor 53 36 18 8 0 5 10
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR1B Serotonin 1b (5-HT1b) receptor 53 36 18 8 0 5 10
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR2A Serotonin 2a (5-HT2a) receptor 83 60 24 18 0 8 22
Enzyme Transferase n.a. CHAT Choline acetylase 1 1 1 0 0 0 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR2C Serotonin 2c (5-HT2c) receptor 77 56 24 15 0 6 19
Enzyme Kinase Protein Kinase MAPK1 MAP kinase ERK2 393 287 175 114 0 16 75
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR1E Serotonin 1e (5-HT1e) receptor 39 23 15 5 0 5 8
Enzyme Oxidoreductase n.a. HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 199 74 4 56 0 2 38
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADORA2A Adenosine A2a receptor 221 117 14 77 0 4 55
Enzyme Kinase Protein Kinase EPHA2 Ephrin type-A receptor 2 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase EPHA3 Ephrin type-A receptor 3 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase EPHA8 Ephrin type-A receptor 8 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase EPHB2 Ephrin type-B receptor 2 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase LTK Leukocyte tyrosine kinase receptor 8 3 0 3 0 0 2
Enzyme Protease Cysteine protease CASP1 Caspase-1 21 13 2 9 0 0 14
Enzyme n.a. n.a. NOS3 Nitric-oxide synthase, endothelial 8 6 1 5 0 1 1
Enzyme n.a. n.a. NOS1 Nitric-oxide synthase, brain 9 6 1 5 0 1 1
Enzyme Kinase Protein Kinase TYK2 Tyrosine-protein kinase TYK2 2 1 0 1 0 0 1
Enzyme Phosphatase Protein Phosphatase CDC25A Dual specificity phosphatase Cdc25A 31 18 3 4 0 1 1
Enzyme Phosphatase Protein Phosphatase CDC25B Dual specificity phosphatase Cdc25B 578 231 37 155 0 15 123
Enzyme Kinase Protein Kinase AXL Tyrosine-protein kinase receptor UFO 1356 562 132 395 0 36 318
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADORA1 Adenosine A1 receptor 223 118 14 78 0 4 55
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) AGTR1 Type-1 angiotensin II receptor 1 1 0 1 0 0 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR1F Serotonin 1f (5-HT1f) receptor 39 23 15 5 0 5 8
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC5A2 Sodium/glucose cotransporter 2 62 20 9 13 0 2 14
Ion channel Ligand-gated ion channel GABA-A receptor GABRA5 GABA receptor alpha-5 subunit 3 2 1 1 0 0 1
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC6A4 Serotonin transporter 83 67 63 10 0 6 22
Enzyme Kinase Protein Kinase AKT1 Serine/threonine-protein kinase AKT 2 1 0 1 0 0 1
Enzyme Kinase Protein Kinase AKT2 Serine/threonine-protein kinase AKT2 2 1 0 1 0 0 1
Enzyme n.a. n.a. ATIC AICAR transformylase 1 0 0 0 0 0 0
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) CCKBR Cholecystokinin B receptor 1 1 0 0 0 0 0
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor CHRNA3 Neuronal acetylcholine receptor subunit alpha-3 7 6 2 3 0 1 3
Enzyme Kinase Protein Kinase GRK4 G protein-coupled receptor kinase 4 1 0 0 1 0 0 1
Enzyme Hydrolase n.a. CDA Cytidine deaminase 122 61 10 45 0 3 27
Enzyme Cytochrome P450 Cytochrome P450 family 2 CYP2C19 Cytochrome P450 2C19 320 121 17 87 0 7 85
Transporter Primary active transporter ATP-binding cassette ABCC1 Multidrug resistance-associated protein 1 1 0 0 0 0 0 0
Ion channel Ligand-gated ion channel GABA-A receptor GABRA3 GABA receptor alpha-3 subunit 3 2 1 1 0 0 1
Enzyme Protease Serine protease EPHX2 Epoxide hydratase 6 4 1 4 0 1 1
Enzyme Kinase Protein Kinase GRK5 G protein-coupled receptor kinase 5 8 3 0 3 0 0 2
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR7 Serotonin 7 (5-HT7) receptor 125 66 23 34 0 8 31
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) CNR2 Cannabinoid CB2 receptor 554 221 43 172 0 13 151
Membrane receptor Family B G protein-coupled receptor Peptide receptor (family B GPCR) CRHR1 Corticotropin releasing factor receptor 1 1 1 1 0 0 1 0
Enzyme Lyase n.a. CA5A Carbonic anhydrase VA 76 28 7 15 0 2 22
Enzyme n.a. n.a. NOS2 Nitric oxide synthase, inducible 2 1 0 1 0 0 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADRA1A Alpha-1a adrenergic receptor 88 38 7 31 0 4 27
Enzyme Oxidoreductase n.a. PTGS2 Cyclooxygenase-2 259 114 22 64 0 6 61
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HRH1 Histamine H1 receptor 21 11 5 9 0 1 7
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADRA1B Alpha-1b adrenergic receptor 27 11 2 6 0 2 9
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) OPRM1 Mu opioid receptor 37 15 1 6 0 2 13
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 RORA Nuclear receptor ROR-alpha 2 1 0 1 0 0 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) DRD3 Dopamine D3 receptor 162 85 28 35 0 8 48
Ion channel Voltage-gated ion channel Voltage-gated sodium channel SCN1A Sodium channel protein type I alpha subunit 9 5 0 3 0 0 2
Ion channel Voltage-gated ion channel Voltage-gated sodium channel SCN4A Sodium channel protein type IV alpha subunit 9 5 0 3 0 0 2
Enzyme n.a. n.a. GCK Hexokinase type IV 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase GRK3 Beta-adrenergic receptor kinase 2 1 0 0 1 0 0 1
Transcription factor n.a. n.a. AHR Aryl hydrocarbon receptor 863 342 108 242 1 26 184
Enzyme Kinase Protein Kinase FLT4 Vascular endothelial growth factor receptor 3 5 2 0 3 0 0 2
Enzyme Kinase Protein Kinase KDR Vascular endothelial growth factor receptor 2 1588 640 144 448 0 40 392
Enzyme Kinase Protein Kinase MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 1 0 0 1 0 0 1
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor CHRNA7 Neuronal acetylcholine receptor protein alpha-7 subunit 2 2 0 2 0 0 1
Enzyme Kinase Protein Kinase FLT3 Tyrosine-protein kinase receptor FLT3 1606 664 150 465 1 43 364
Enzyme Kinase Protein Kinase ACVRL1 Serine/threonine-protein kinase receptor R3 1 0 0 1 0 0 1
Enzyme Oxidoreductase n.a. HSD17B3 Estradiol 17-beta-dehydrogenase 3 25 9 3 9 0 1 3
Enzyme Oxidoreductase n.a. HSD17B2 Estradiol 17-beta-dehydrogenase 2 887 361 112 251 1 26 176
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 PPARG Peroxisome proliferator-activated receptor gamma 66 44 3 27 0 0 25
Unclassified protein n.a. n.a. SNCA Alpha-synuclein 565 323 182 171 0 20 127
Enzyme n.a. n.a. BRCA1 Breast cancer type 1 susceptibility protein 15 12 2 8 0 0 10
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor GRIK1 Glutamate receptor ionotropic kainate 1 158 114 127 30 0 8 29
Enzyme Protease Metallo protease MMP12 Matrix metalloproteinase 12 689 303 78 202 1 18 176
Secreted protein n.a. n.a. THPO Thrombopoietin 769 329 59 223 0 20 209
Transcription factor n.a. n.a. STAT3 Signal transducer and activator of transcription 3 16 11 1 7 0 1 6
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) OPRD1 Delta opioid receptor 112 49 5 25 0 8 29
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) OPRK1 Kappa opioid receptor 10 4 1 2 0 0 5
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) P2RY2 Purinergic receptor P2Y2 1 1 1 0 0 0 0
Enzyme Kinase Protein Kinase CSK Tyrosine-protein kinase CSK 1 0 0 1 0 0 1
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC19A1 Folate transporter 1 1 0 0 0 0 0 0
Membrane receptor Family C G protein-coupled receptor Small molecule receptor (family C GPCR) GRM5 Metabotropic glutamate receptor 5 3 2 0 1 0 0 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR2B Serotonin 2b (5-HT2b) receptor 146 81 23 40 0 9 37
Enzyme Kinase Protein Kinase PRKCI Protein kinase C iota 1 0 0 1 0 0 1
Transcription factor n.a. n.a. STAT1 Signal transducer and activator of transcription 1-alpha/beta 17 5 0 5 0 1 6
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor GRIA1 Glutamate receptor ionotropic, AMPA 1 2 2 0 0 0 0 0
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor GRIA2 Glutamate receptor ionotropic, AMPA 2 2 2 0 0 0 0 0
Enzyme n.a. n.a. AKR1C3 Aldo-keto-reductase family 1 member C3 568 295 142 169 1 17 146
Enzyme Transferase n.a. PIK3CA PI3-kinase p110-alpha subunit 154 70 12 42 0 1 28
Enzyme Transferase n.a. PIK3CB PI3-kinase p110-beta subunit 154 70 12 42 0 1 28
Enzyme Kinase Protein Kinase MTOR Serine/threonine-protein kinase mTOR 76 44 6 17 0 5 19
Enzyme Protease Cysteine protease CASP3 Caspase-3 4 3 1 1 0 0 4
Enzyme Kinase Protein Kinase MATK Tyrosine-protein kinase CTK 2 0 0 2 0 0 1
Enzyme Kinase Protein Kinase TEC Tyrosine-protein kinase TEC 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase TXK Tyrosine-protein kinase TXK 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase ABL2 Tyrosine-protein kinase ABL2 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase FRK Tyrosine-protein kinase FRK 4 1 0 3 0 0 1
Unclassified protein n.a. n.a. HTT Huntingtin 42 22 2 12 0 0 27
Enzyme Lyase n.a. CA7 Carbonic anhydrase VII 2259 889 172 652 3 57 512
Membrane receptor Family B G protein-coupled receptor Peptide receptor (family B GPCR) GLP1R Glucagon-like peptide 1 receptor 1 1 0 1 0 0 1
Enzyme Protease Cysteine protease CTSK Cathepsin K 8 6 2 3 0 0 2
Enzyme Kinase Protein Kinase GRK6 G protein-coupled receptor kinase 6 1 0 0 1 0 0 1
Other nuclear protein n.a. n.a. RAD52 DNA repair protein RAD52 homolog 101 43 9 32 0 5 21
Enzyme Kinase Protein Kinase ZAP70 Tyrosine-protein kinase ZAP-70 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase SYK Tyrosine-protein kinase SYK 2 0 0 2 0 0 1
Enzyme Kinase Protein Kinase MAPK8 c-Jun N-terminal kinase 1 2 0 0 2 0 0 1
Enzyme Kinase Protein Kinase MAPK9 c-Jun N-terminal kinase 2 1 0 0 1 0 0 0
Enzyme Kinase Protein Kinase MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4 163 94 47 44 1 8 17
Enzyme n.a. n.a. RECQL ATP-dependent DNA helicase Q1 1116 451 104 317 0 29 266
Ion channel Ligand-gated ion channel 5HT3 receptor HTR3A Serotonin 3a (5-HT3a) receptor 43 27 18 6 0 6 8
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) BDKRB1 Bradykinin B1 receptor 1 1 0 1 0 0 0
Enzyme Kinase Protein Kinase MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 1 0 0 1 0 0 1
Ion channel Ligand-gated ion channel GABA-A receptor GABRA2 GABA receptor alpha-2 subunit 3 2 1 1 0 0 1
Membrane receptor Family B G protein-coupled receptor Peptide receptor (family B GPCR) GCGR Glucagon receptor 2 0 0 1 0 0 1
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR5A Serotonin 5a (5-HT5a) receptor 103 46 18 28 0 7 26
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) P2RY1 Purinergic receptor P2Y1 1 1 1 0 0 0 0
Enzyme Oxidoreductase n.a. XDH Xanthine dehydrogenase 167 60 6 47 0 3 42
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) MTNR1A Melatonin receptor 1A 11 11 3 1 0 1 0
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor GRIA4 Glutamate receptor ionotropic, AMPA 4 142 111 127 25 0 8 22
Enzyme Protease Serine protease PREP Prolyl endopeptidase 2 1 1 0 0 0 0
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 2 RXRG Retinoid X receptor gamma 2 1 0 1 0 0 0
Enzyme Kinase Protein Kinase CSNK1A1 Casein kinase I alpha 11 5 0 4 0 0 2
Enzyme Kinase Protein Kinase CSNK1D Casein kinase I delta 1 0 0 1 0 0 0
Enzyme Transferase n.a. PIK3CG PI3-kinase p110-gamma subunit 1 0 0 0 0 0 0
Enzyme Oxidoreductase n.a. TDO2 Tryptophan 2,3-dioxygenase 13 7 5 2 0 0 3
Enzyme Kinase Protein Kinase MAPKAPK2 MAP kinase-activated protein kinase 2 1 0 0 1 0 0 1
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) MTNR1B Melatonin receptor 1B 11 11 3 1 0 1 0
Enzyme Kinase Protein Kinase CDK8 Cell division protein kinase 8 134 48 6 37 0 4 35
Enzyme Kinase Protein Kinase CLK1 Dual specificty protein kinase CLK1 6 3 0 4 0 0 1
Enzyme Kinase Protein Kinase CLK2 Dual specificity protein kinase CLK2 10 3 0 4 0 0 2
Enzyme Kinase Protein Kinase CLK3 Dual specificity protein kinase CLK3 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase GSK3A Glycogen synthase kinase-3 alpha 2 0 0 1 0 0 1
Enzyme Kinase Protein Kinase GSK3B Glycogen synthase kinase-3 beta 6 3 0 3 0 0 1
Enzyme Transferase n.a. HNMT Histamine N-methyltransferase 1 0 0 0 0 0 1
Enzyme Transferase n.a. SULT1A1 Sulfotransferase 1A1 65 55 62 4 0 5 16
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR6 Serotonin 6 (5-HT6) receptor 144 75 23 34 0 7 31
Enzyme Protease Metallo protease METAP2 Methionine aminopeptidase 2 5 1 0 1 0 0 1
Enzyme Kinase Protein Kinase CDK7 Cyclin-dependent kinase 7 1 0 0 0 0 0 0
Enzyme Kinase Protein Kinase CDK9 Cyclin-dependent kinase 9 1 0 0 0 0 0 0
Enzyme Hydrolase n.a. RAB9A Ras-related protein Rab-9A 171 67 15 47 0 6 58
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 RORC Nuclear receptor ROR-gamma 839 306 46 229 0 22 202
Enzyme Kinase Protein Kinase BLK Tyrosine-protein kinase BLK 2 0 0 2 0 0 1
Ion channel Ligand-gated ion channel P2X receptor P2RX1 P2X purinoceptor 1 1 1 1 0 0 0 0
Enzyme Kinase Protein Kinase IRAK1 Interleukin-1 receptor-associated kinase 1 3 1 0 2 0 0 1
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) CCR6 C-C chemokine receptor type 6 1 0 0 0 0 0 1
Enzyme Kinase Protein Kinase RPS6KA3 Ribosomal protein S6 kinase alpha 3 4 1 0 4 0 0 1
Enzyme Kinase Protein Kinase BMX Tyrosine-protein kinase BMX 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase PRKX Serine/threonine-protein kinase PRKX 8 3 0 3 0 0 2
Enzyme Kinase Protein Kinase NEK2 Serine/threonine-protein kinase NEK2 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase NEK4 Serine/threonine-protein kinase Nek4 1 0 0 1 0 0 1
Enzyme Oxidoreductase n.a. PGD 6-phosphogluconate dehydrogenase 198 82 22 60 0 9 39
Enzyme Kinase Protein Kinase JAK3 Tyrosine-protein kinase JAK3 3 1 0 2 0 0 1
Enzyme Kinase Protein Kinase MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase PLK1 Serine/threonine-protein kinase PLK1 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase DAPK1 Death-associated protein kinase 1 1 0 0 1 0 0 1
Enzyme Transferase n.a. ACLY ATP-citrate synthase 1 1 0 0 0 0 0
Enzyme Kinase Protein Kinase LIMK1 LIM domain kinase 1 13 6 1 2 0 0 3
Enzyme Kinase Protein Kinase LIMK2 LIM domain kinase 2 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase MAPK12 MAP kinase p38 gamma 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase MAPK10 c-Jun N-terminal kinase 3 10 4 0 4 0 0 1
Enzyme n.a. n.a. BLM Bloom syndrome protein 541 264 81 157 1 18 111
Auxiliary transport protein Calcium channel auxiliary subunit alpha2delta family n.a. CACNA2D1 Voltage-gated calcium channel alpha2/delta subunit 1 2 2 1 0 0 1 0
Enzyme Hydrolase n.a. ATP12A Potassium-transporting ATPase alpha chain 2 31 13 4 6 0 3 13
Enzyme Kinase Protein Kinase EPHA5 Ephrin type-A receptor 5 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase EPHB4 Ephrin type-B receptor 4 4 2 0 2 0 0 2
Enzyme Kinase Protein Kinase EPHB1 Ephrin type-B receptor 1 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase EPHA4 Ephrin type-A receptor 4 1 0 0 1 0 0 1
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) F2RL1 Proteinase-activated receptor 2 1 1 0 0 0 0 0
Enzyme Protease Cysteine protease CASP7 Caspase-7 15 12 2 8 0 0 10
Enzyme Protease Cysteine protease CASP6 Caspase-6 396 170 74 107 0 13 86
Enzyme n.a. n.a. GFER FAD-linked sulfhydryl oxidase ALR 240 101 13 63 0 4 65
Ion channel Ligand-gated ion channel P2X receptor P2RX3 P2X purinoceptor 3 2 1 1 0 0 0 1
Epigenetic regulator Eraser Histone deacetylase HDAC4 Histone deacetylase 4 1 0 0 0 0 0 0
Enzyme Protease Aspartic protease BACE1 Beta-secretase 1 76 27 3 24 0 6 16
Enzyme Kinase Protein Kinase SIK1 Serine/threonine-protein kinase SIK1 1 0 0 1 0 0 1
Enzyme Hydrolase n.a. EIF4A1 Eukaryotic initiation factor 4A-I 38 9 1 6 0 0 12
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 ESRRG Estrogen-related receptor gamma 1 1 1 0 0 0 0
Enzyme Isomerase n.a. PPIA Cyclophilin A 4 4 1 2 0 0 2
Enzyme Isomerase n.a. FKBP1A FK506-binding protein 1A 6 5 1 2 0 0 3
Enzyme Isomerase n.a. FKBP1B FK506-binding protein 1B 4 4 1 2 0 0 2
Enzyme Kinase Protein Kinase CSNK2A1 Casein kinase II alpha 1025 407 77 300 0 25 272
Secreted protein n.a. n.a. HBB Hemoglobin beta chain 27 21 2 11 0 1 12
Enzyme Kinase Protein Kinase SRPK2 Serine/threonine-protein kinase SRPK2 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase MAP3K9 Mitogen-activated protein kinase kinase kinase 9 1 0 0 1 0 0 1
Enzyme n.a. n.a. HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 16 9 1 4 0 0 0
Transcription factor n.a. n.a. SMAD3 Mothers against decapentaplegic homolog 3 294 115 23 93 0 5 70
Enzyme Kinase Protein Kinase CDK3 Cyclin-dependent kinase 3 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase CDK6 Cyclin-dependent kinase 6 66 22 4 14 0 2 15
Enzyme Kinase Protein Kinase CDK5 Cyclin-dependent kinase 5 2 0 0 0 0 0 0
Other nuclear protein n.a. n.a. MDM2 p53-binding protein Mdm-2 7 2 0 1 0 0 6
Unclassified protein n.a. n.a. PMP22 Peripheral myelin protein 22 73 43 6 16 0 5 18
Auxiliary transport protein Fatty acid binding protein family n.a. FABP5 Fatty acid binding protein epidermal 479 250 113 149 1 12 114
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC6A3 Dopamine transporter 75 63 71 6 0 5 16
Enzyme Kinase Protein Kinase PRKCE Protein kinase C epsilon 13 7 0 8 0 1 7
Enzyme Kinase Protein Kinase MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 54 21 3 16 0 2 13
Enzyme Kinase Protein Kinase TEK Tyrosine-protein kinase TIE-2 305 123 24 100 0 5 72
Enzyme Kinase Protein Kinase MAP3K10 Mitogen-activated protein kinase kinase kinase 10 8 3 0 3 0 0 2
Enzyme Isomerase n.a. FKBP4 FK506 binding protein 4 4 4 1 2 0 0 2
Enzyme Isomerase n.a. TOP2B DNA topoisomerase II beta 10 6 3 4 0 1 1
Epigenetic regulator Writer Protein methyltransferase KMT2A Histone-lysine N-methyltransferase MLL 90 50 7 33 0 5 34
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 PPARD Peroxisome proliferator-activated receptor delta 30 19 15 3 0 2 8
Transcription factor n.a. n.a. RELA Nuclear factor NF-kappa-B p65 subunit 708 261 31 207 0 17 171
Enzyme Protease Serine protease HGFAC Hepatocyte growth factor activator 1 1 0 0 0 0 1
Enzyme Kinase Protein Kinase PRKCQ Protein kinase C theta 10 5 0 5 0 1 3
Enzyme Lyase n.a. GLO1 Glyoxalase I 441 194 72 124 0 15 91
Enzyme Kinase Protein Kinase ACVR1 Activin receptor type-1 7 3 0 2 0 0 1
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor CHRNE Acetylcholine receptor protein epsilon chain 2 2 1 0 0 1 0
Enzyme Kinase Protein Kinase MST1R Macrophage-stimulating protein receptor 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase PTK2 Focal adhesion kinase 1 41 14 1 7 0 1 16
Enzyme Kinase Protein Kinase PRKCZ Protein kinase C zeta 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase PRKCD Protein kinase C delta 16 9 0 6 0 1 6
Enzyme Kinase Protein Kinase BTK Tyrosine-protein kinase BTK 8 3 0 3 0 0 2
Enzyme Oxidoreductase n.a. AOX1 Aldehyde oxidase 220 140 97 49 1 11 30
Enzyme Kinase Protein Kinase TYRO3 Tyrosine-protein kinase receptor TYRO3 8 3 0 3 0 0 2
Transcription factor n.a. n.a. PAX8 Paired box protein Pax-8 99 33 8 26 0 1 24
Enzyme Phosphodiesterase Phosphodiesterase 4 PDE4B Phosphodiesterase 4B 7 6 0 4 0 0 0
Ion channel Other ion channel Miscellaneous ion channel BCL2L1 Apoptosis regulator Bcl-X 4 4 1 2 0 0 1
Other cytosolic protein n.a. n.a. MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 27 10 1 9 0 2 6
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 PPARA Peroxisome proliferator-activated receptor alpha 497 258 116 152 1 12 118
Enzyme Kinase Protein Kinase TNK2 Tyrosine kinase non-receptor protein 2 8 3 0 3 0 0 2
Enzyme Cytochrome P450 Cytochrome P450 family 24 CYP24A1 Cytochrome P450 24A1 1 0 0 0 0 0 0
Enzyme Phosphatase Protein Phosphatase PPP3CA Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform 5 5 1 2 0 0 3
Enzyme Kinase Protein Kinase DDR1 Epithelial discoidin domain-containing receptor 1 1 0 0 1 0 0 1
Enzyme Phosphodiesterase Phosphodiesterase 4 PDE4D Phosphodiesterase 4D 34 22 4 19 0 0 4
Enzyme n.a. n.a. ADCY1 Brain adenylate cyclase 1 1 0 0 0 0 0 0
Enzyme Kinase Protein Kinase ITK Tyrosine-protein kinase ITK/TSK 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase DMPK Myotonin-protein kinase 1 0 0 1 0 0 1
Enzyme Transferase n.a. FUT7 Alpha-(1,3)-fucosyltransferase 7 605 265 68 182 0 18 134
Transcription factor n.a. n.a. SREBF2 Sterol regulatory element-binding protein 2 1 1 1 0 0 0 1
Ion channel Voltage-gated ion channel Potassium channels KCNH2 HERG 17 13 2 6 0 1 8
Enzyme Kinase Protein Kinase MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 1 0 0 1 0 0 0
Enzyme Kinase Protein Kinase MAP3K12 Mitogen-activated protein kinase kinase kinase 12 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase MERTK Proto-oncogene tyrosine-protein kinase MER 1 0 0 1 0 0 1
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor GRIK2 Glutamate receptor ionotropic kainate 2 16 3 0 5 0 0 7
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor GRIK3 Glutamate receptor ionotropic kainate 3 158 114 127 30 0 8 29
Enzyme Kinase Protein Kinase STK4 Serine/threonine-protein kinase MST1 1 0 0 1 0 0 1
Enzyme Hydrolase n.a. PLA2G7 LDL-associated phospholipase A2 3 3 1 2 0 1 0
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 NR1H3 LXR-alpha 7 1 1 4 0 0 1
Enzyme Kinase Protein Kinase PAK1 Serine/threonine-protein kinase PAK 1 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase PAK2 Serine/threonine-protein kinase PAK 2 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase STK3 Serine/threonine-protein kinase MST2 9 3 0 4 0 0 2
Enzyme Kinase Protein Kinase MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase PRKG2 cGMP-dependent protein kinase 2 1 0 0 1 0 0 1
Membrane receptor Family C G protein-coupled receptor Small molecule receptor (family C GPCR) GRM1 Metabotropic glutamate receptor 1 145 113 127 26 0 8 22
Enzyme Kinase Protein Kinase ATM Serine-protein kinase ATM 2 1 0 1 0 0 0
Enzyme Phosphatase Protein Phosphatase PTPRS Receptor-type tyrosine-protein phosphatase S 30 17 1 13 0 0 5
Enzyme Protease Metallo protease ADAM9 ADAM9 1 0 0 0 0 0 0
Enzyme n.a. n.a. FKBP5 Peptidyl-prolyl cis-trans isomerase FKBP5 2 1 0 0 0 0 1
Enzyme Kinase Protein Kinase ROCK1 Rho-associated protein kinase 1 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase TNK1 Non-receptor tyrosine-protein kinase TNK1 1 0 0 1 0 0 1
Structural protein n.a. n.a. TUBB3 Tubulin beta-3 chain 37 20 5 11 0 4 13
Enzyme Isomerase n.a. PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 2 1 0 1 0 0 0
Enzyme Kinase Protein Kinase ATR Serine-protein kinase ATR 2 1 0 1 0 0 0
Epigenetic regulator Eraser Histone deacetylase HDAC1 Histone deacetylase 1 2 0 0 0 0 0 0
Enzyme Kinase Protein Kinase CAMK2B CaM kinase II beta 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase CAMK2G CaM kinase II gamma 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase CAMK2D CaM kinase II delta 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A 118 50 10 39 0 5 25
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR4 Serotonin 4 (5-HT4) receptor 39 23 15 5 0 5 8
Enzyme Kinase Protein Kinase PTK6 Tyrosine-protein kinase BRK 3 1 0 2 0 0 1
Transcription factor n.a. n.a. KLF5 Kruppel-like factor 5 4 3 0 1 0 0 3
Ion channel Voltage-gated ion channel Voltage-gated calcium channel CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit 8 6 1 5 0 0 0
Enzyme Kinase Protein Kinase PRKG1 cGMP-dependent protein kinase 1 beta 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase CAMK1 CaM kinase I alpha 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase IKBKE Inhibitor of nuclear factor kappa B kinase epsilon subunit 8 3 0 3 0 0 2
Enzyme Kinase Protein Kinase PTK2B Protein tyrosine kinase 2 beta 1 0 0 1 0 0 1
Enzyme Phosphodiesterase Phosphodiesterase 3 PDE3A Phosphodiesterase 3A 9 7 2 2 0 0 5
Ion channel Voltage-gated ion channel Voltage-gated sodium channel SCN5A Sodium channel protein type V alpha subunit 8 5 0 2 0 0 2
Enzyme Kinase Protein Kinase MELK Maternal embryonic leucine zipper kinase 9 3 0 4 0 0 2
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 NR1I3 Nuclear receptor subfamily 1 group I member 3 1 1 0 1 0 0 0
Enzyme n.a. n.a. KARS1 Lysyl-tRNA synthetase 104 30 7 34 0 3 24
Enzyme Kinase Protein Kinase PDK1 Pyruvate dehydrogenase kinase isoform 1 1 0 0 1 0 0 1
Enzyme Isomerase n.a. EBP 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase 5 5 0 3 0 0 0
Enzyme Kinase Protein Kinase PRKD1 Protein kinase C mu 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase STK38 Serine/threonine-protein kinase 38 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase ERBB4 Receptor protein-tyrosine kinase erbB-4 3 1 0 2 0 0 1
Enzyme Kinase Protein Kinase RPS6KA2 Ribosomal protein S6 kinase alpha 2 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase EPHA7 Ephrin type-A receptor 7 1 0 0 1 0 0 1
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) P2RY14 Purinergic receptor P2Y14 1 1 0 0 0 0 0
Other nuclear protein n.a. n.a. SF3B3 Splicing factor 3B subunit 3 2 1 0 0 0 0 1
Enzyme Kinase Protein Kinase RPS6KA1 Ribosomal protein S6 kinase alpha 1 1 0 0 1 0 0 1
Unclassified protein n.a. n.a. SHH Sonic hedgehog protein 11 7 1 4 0 0 2
Enzyme Kinase Protein Kinase TESK1 Dual specificity testis-specific protein kinase 1 1 0 0 1 0 0 1
Unclassified protein n.a. n.a. ELAVL1 ELAV-like protein 1 36 15 0 2 0 0 7
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) LTB4R Leukotriene B4 receptor 1 2 2 1 1 0 1 0
Enzyme Kinase Protein Kinase MYLK Myosin light chain kinase, smooth muscle 1 0 0 1 0 0 1
Unclassified protein n.a. n.a. TAB1 Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase MAPK11 MAP kinase p38 beta 1 0 0 1 0 0 0
Enzyme Kinase Protein Kinase STK11 Serine/threonine-protein kinase 11 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase GRK1 Rhodopsin kinase 1 0 0 1 0 0 1
Ion channel Voltage-gated ion channel Voltage-gated sodium channel SCN9A Sodium channel protein type IX alpha subunit 9 5 0 3 0 0 2
Transporter Primary active transporter F-type and V-type ATPases ATP6AP1 Vacuolar ATP synthase subunit S1 1 0 0 0 0 0 1
Transcription factor n.a. n.a. NFE2L2 Nuclear factor erythroid 2-related factor 2 18 7 2 5 1 1 3
Enzyme Kinase Protein Kinase NTRK3 NT-3 growth factor receptor 2 0 0 2 0 0 1
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor GRIK5 Glutamate receptor ionotropic kainate 5 158 114 127 30 0 8 29
Enzyme Kinase Protein Kinase PKN1 Protein kinase N1 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase PKN2 Protein kinase N2 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase MAPK14 MAP kinase p38 alpha 18 11 2 6 0 0 1
Enzyme Kinase Protein Kinase CAMK4 CaM kinase IV 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase MAP3K11 Mitogen-activated protein kinase kinase kinase 11 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase NTRK2 Neurotrophic tyrosine kinase receptor type 2 2 0 0 2 0 0 1
Epigenetic regulator Reader Methyl-lysine/arginine binding protein SMN1 Survival motor neuron protein 328 157 26 91 0 9 101
Transcription factor n.a. n.a. HIF1A Hypoxia-inducible factor 1 alpha 936 390 94 264 1 22 244
Enzyme Cytochrome P450 Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 2147 861 171 584 2 48 513
Enzyme Cytochrome P450 Cytochrome P450 family 2 CYP2A13 Cytochrome P450 2A13 76 40 8 23 0 1 39
Enzyme Lyase n.a. CA9 Carbonic anhydrase IX 1053 463 60 310 0 24 285
Enzyme Kinase Protein Kinase PHKG1 Phosphorylase kinase gamma subunit 1 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase DDR2 Discoidin domain-containing receptor 2 4 2 0 2 0 0 2
Enzyme Cytochrome P450 Cytochrome P450 family 51 CYP51A1 Cytochrome P450 51 1 1 0 1 0 0 0
Enzyme n.a. n.a. PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 15 4 1 4 0 0 3
Unclassified protein n.a. n.a. MPEG1 Macrophage-expressed gene 1 protein 19 14 0 7 0 1 0
Enzyme Kinase Protein Kinase MYLK3 Myosin light chain kinase 1 0 0 1 0 0 1
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22A6 Solute carrier family 22 member 6 294 115 23 93 0 5 70
Enzyme Kinase Protein Kinase SBK1 Serine/threonine-protein kinase SBK1 1 0 0 1 0 0 1
Unclassified protein n.a. n.a. PDCD4 Programmed cell death protein 4 1 0 0 0 0 0 0
Enzyme Kinase Protein Kinase MAP3K19 SPS1/STE20-related protein kinase YSK4 1 0 0 1 0 0 1
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) FFAR4 G-protein coupled receptor 120 549 288 141 166 1 17 139
Enzyme Kinase Protein Kinase LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 8 3 0 3 0 0 2
Enzyme Kinase Protein Kinase CDC42BPA Serine/threonine-protein kinase MRCK-A 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase CDC42BPG Serine/threonine-protein kinase MRCK gamma 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase NEK5 Serine/threonine-protein kinase Nek5 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase ULK3 Serine/threonine-protein kinase ULK3 1 0 0 1 0 0 1
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) NPSR1 Neuropeptide S receptor 1374 576 137 407 0 37 313
Enzyme n.a. n.a. DSTYK Dual serine/threonine and tyrosine protein kinase 1 0 0 1 0 0 1
Transporter Electrochemical transporter SLC superfamily of solute carriers SLCO4C1 Solute carrier organic anion transporter family member 4C1 12 8 1 5 0 1 3
Enzyme Kinase Protein Kinase MARK2 MAP/microtubule affinity-regulating kinase 2 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase TAOK1 Serine/threonine-protein kinase TAO1 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase TLK2 Serine/threonine-protein kinase tousled-like 2 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase STK32C Serine/threonine-protein kinase 32C 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase PIM3 Serine/threonine-protein kinase PIM3 2 0 0 2 0 0 1
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC47A2 Multidrug and toxin extrusion protein 2 4 1 0 1 0 0 0
Enzyme Kinase Protein Kinase MYLK4 Myosin light chain kinase family member 4 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase HIPK1 Homeodomain-interacting protein kinase 1 3 2 0 1 0 0 1
Enzyme Kinase Protein Kinase CAMK1D CaM kinase I delta 8 3 0 3 0 0 2
Enzyme Kinase Protein Kinase MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase MAPKAPK5 MAP kinase-activated protein kinase 5 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase BRSK2 BR serine/threonine-protein kinase 2 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase NIM1K Serine/threonine-protein kinase NIM1 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase ULK2 Serine/threonine-protein kinase ULK2 1 0 0 1 0 0 1
Enzyme Lyase n.a. CA13 Carbonic anhydrase XIII 4 1 0 0 0 0 0
Enzyme n.a. n.a. ABHD12 Monoacylglycerol lipase ABHD12 3 3 1 2 0 1 0
Enzyme Kinase Protein Kinase MINK1 Misshapen-like kinase 1 2 0 0 2 0 0 1
Enzyme Kinase Protein Kinase DCLK2 Serine/threonine-protein kinase DCLK2 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase CAMKK1 CaM-kinase kinase alpha 1 0 0 1 0 0 1
Enzyme n.a. n.a. DAGLB Sn1-specific diacylglycerol lipase beta 3 3 1 2 0 1 0
Enzyme Kinase Protein Kinase HIPK4 Homeodomain-interacting protein kinase 4 4 2 0 2 0 0 2
Ion channel Voltage-gated ion channel Transient receptor potential channel TRPV1 Vanilloid receptor 91 33 9 23 0 3 24
Enzyme Kinase Protein Kinase MYO3A Myosin IIIA 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase NEK11 Serine/threonine-protein kinase Nek11 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase MAPK15 Mitogen-activated protein kinase 15 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase NEK9 Serine/threonine-protein kinase NEK9 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase BRSK1 BR serine/threonine-protein kinase 1 2 0 0 2 0 0 1
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HCAR2 Hydroxycarboxylic acid receptor 2 277 179 180 69 0 12 61
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) GPBAR1 G-protein coupled bile acid receptor 1 4 2 0 2 0 0 2
Enzyme Hydrolase n.a. GANC Neutral alpha-glucosidase C 1 0 0 0 0 0 0
Enzyme Kinase Protein Kinase HASPIN Serine/threonine-protein kinase haspin 10 8 3 4 0 1 2
Enzyme Kinase Protein Kinase GRK7 G protein-coupled receptor kinase 7 1 0 0 1 0 0 1
Epigenetic regulator Eraser Histone deacetylase HDAC7 Histone deacetylase 7 1 0 0 0 0 0 0
Enzyme Kinase Protein Kinase MYO3B Myosin-IIIB 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 5 3 0 4 0 0 1
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 ESR2 Estrogen receptor beta 982 449 138 281 1 28 233
Epigenetic regulator Eraser Histone deacetylase HDAC2 Histone deacetylase 2 9 4 0 1 0 0 1
Epigenetic regulator Eraser Histone deacetylase HDAC10 Histone deacetylase 10 1 0 0 0 0 0 0
Enzyme Kinase Protein Kinase SGK3 Serine/threonine-protein kinase Sgk3 1 0 0 1 0 0 1
Epigenetic regulator Eraser Histone deacetylase HDAC11 Histone deacetylase 11 1 0 0 0 0 0 0
Epigenetic regulator Eraser Histone deacetylase SIRT1 NAD-dependent deacetylase sirtuin 1 1 0 0 1 0 0 0
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC47A1 Multidrug and toxin extrusion protein 1 4 1 0 1 0 0 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) P2RY11 Purinergic receptor P2Y11 1 0 0 1 0 0 0
Enzyme Kinase Protein Kinase AURKB Serine/threonine-protein kinase Aurora-B 1426 581 136 410 0 37 336
Enzyme Kinase Protein Kinase PBK PDZ-binding kinase 1 0 0 1 0 0 1
Epigenetic regulator Writer Protein methyltransferase EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 1 1 0 1 0 0 0
Enzyme Kinase Protein Kinase MARK4 MAP/microtubule affinity-regulating kinase 4 8 3 0 3 0 0 2
Enzyme Kinase Protein Kinase CAMK1G CaM kinase I gamma 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase TSSK2 Testis-specific serine/threonine-protein kinase 2 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase NEK1 Serine/threonine-protein kinase Nek1 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase PASK PAS domain-containing serine/threonine-protein kinase 1 0 0 1 0 0 1
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 NR1H4 Bile acid receptor FXR 1537 531 68 411 0 40 361
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) TAAR1 Trace amine-associated receptor 1 62 36 17 17 0 3 12
Enzyme Kinase Protein Kinase CAMKK2 CaM-kinase kinase beta 8 3 0 3 0 0 2
Enzyme Kinase Protein Kinase SRPK1 Serine/threonine-protein kinase SRPK1 1 0 0 1 0 0 1
Ion channel Voltage-gated ion channel Voltage-gated sodium channel SCN2A Sodium channel protein type II alpha subunit 9 5 0 3 0 0 2
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) GPER1 G-protein coupled estrogen receptor 1 8 6 1 4 0 0 0
Ion channel Ligand-gated ion channel P2X receptor P2RX4 P2X purinoceptor 4 1 1 1 0 0 0 0
Enzyme Kinase Protein Kinase MAP3K5 Mitogen-activated protein kinase kinase kinase 5 1 0 0 1 0 0 1
Enzyme Hydrolase n.a. MGLL Monoglyceride lipase 1 1 0 1 0 0 0
Enzyme Oxidoreductase n.a. HSD17B10 Endoplasmic reticulum-associated amyloid beta-peptide-binding protein 1523 668 144 449 0 43 343
Membrane receptor n.a. n.a. SIGMAR1 Sigma opioid receptor 40 29 2 13 0 0 15
Enzyme Kinase Protein Kinase MAP3K3 Mitogen-activated protein kinase kinase kinase 3 1 0 0 1 0 0 1
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC29A1 Equilibrative nucleoside transporter 1 3 2 1 0 0 0 1
Membrane receptor Frizzled family G protein-coupled receptor Smoothened receptor (frizzled family GPCR) SMO Smoothened homolog 5 2 0 2 0 0 0
Enzyme Protease Serine protease CTRC Chymotrypsin C 1 1 0 1 0 1 0
Enzyme Hydrolase n.a. FUCA2 Alpha-L-fucosidase 2 1 1 1 0 0 0 0
Enzyme Kinase Protein Kinase MKNK1 MAP kinase-interacting serine/threonine-protein kinase MNK1 689 302 78 203 1 18 177
Enzyme Hydrolase n.a. ABHD6 Monoacylglycerol lipase ABHD6 3 3 1 2 0 1 0
Enzyme Kinase Protein Kinase CDK19 Cell division cycle 2-like protein kinase 6 3 2 0 1 0 0 1
Enzyme Kinase Protein Kinase TSSK1B Testis-specific serine/threonine-protein kinase 1 1 0 0 1 0 0 1
Unclassified protein n.a. n.a. EBPL Emopamil-binding protein-like 3 3 0 2 0 0 0
Epigenetic regulator Eraser Histone deacetylase HDAC8 Histone deacetylase 8 9 4 0 1 0 0 1
Enzyme Kinase Protein Kinase STK33 Serine/threonine-protein kinase 33 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase PRKD2 Serine/threonine-protein kinase D2 2 0 0 2 0 0 1
Enzyme Protease Cysteine protease SENP6 Sentrin-specific protease 6 5 3 2 0 0 0 3
Enzyme Kinase Protein Kinase NUAK2 NUAK family SNF1-like kinase 2 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase SIK2 Serine/threonine-protein kinase SIK2 10 4 0 4 0 0 2
Enzyme Kinase Protein Kinase MYLK2 myosin light chain kinase 2 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase SLK Serine/threonine-protein kinase 2 3 1 0 2 0 0 1
Enzyme Transferase n.a. TNKS2 Tankyrase-2 46 25 6 16 1 2 7
Enzyme Kinase Protein Kinase TAOK3 Serine/threonine-protein kinase TAO3 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase HIPK2 Homeodomain-interacting protein kinase 2 5 2 0 3 0 0 2
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HRH4 Histamine H4 receptor 19 9 4 8 0 1 7
Enzyme Kinase Protein Kinase HIPK3 Homeodomain-interacting protein kinase 3 4 2 0 2 0 0 2
Enzyme Kinase Protein Kinase PLK3 Serine/threonine-protein kinase PLK3 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase CLK4 Dual specificity protein kinase CLK4 3 0 0 2 0 0 1
Enzyme Kinase Protein Kinase MKNK2 MAP kinase signal-integrating kinase 2 1066 443 99 303 1 25 283
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) RXFP1 Relaxin receptor 1 1 0 0 0 0 0 0
Enzyme Kinase Protein Kinase SGK2 Serine/threonine-protein kinase Sgk2 9 3 0 4 0 0 2
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) GPR35 G-protein coupled receptor 35 294 115 23 93 0 5 70
Transporter Electrochemical transporter SLC superfamily of solute carriers SLCO1B3 Solute carrier organic anion transporter family member 1B3 145 58 7 41 0 5 34
Enzyme n.a. n.a. NOX4 NADPH oxidase 4 1635 674 151 468 1 44 374
Enzyme Kinase Protein Kinase PAK6 Serine/threonine-protein kinase PAK6 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase SNRK SNF-related serine/threonine-protein kinase 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase LATS2 Serine/threonine-protein kinase LATS2 1 0 0 1 0 0 1
Enzyme Phosphodiesterase n.a. TDP1 Tyrosyl-DNA phosphodiesterase 1 1019 486 117 289 1 28 211
Enzyme Kinase Protein Kinase IRAK4 Interleukin-1 receptor-associated kinase 4 2 0 0 2 0 0 1
Ion channel Voltage-gated ion channel Voltage-gated sodium channel SCN3A Sodium channel protein type III alpha subunit 9 5 0 3 0 0 2
Enzyme Kinase Protein Kinase STK32B Serine/threonine-protein kinase 32B 1 0 0 1 0 0 1
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC5A4 Low affinity sodium-glucose cotransporter 61 20 9 13 0 2 13
Enzyme Kinase Protein Kinase MAP3K20 Mixed lineage kinase 7 1 0 0 1 0 0 0
Enzyme Kinase Protein Kinase PLK2 Serine/threonine-protein kinase PLK2 1 0 0 1 0 0 1
Enzyme Protease Metallo protease ERAP1 Endoplasmic reticulum aminopeptidase 1 4 2 0 2 0 0 0
Enzyme Kinase Protein Kinase MARK1 Serine/threonine-protein kinase MARK1 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase PIM2 Serine/threonine-protein kinase PIM2 2 0 0 2 0 0 1
Enzyme Kinase Protein Kinase PAK5 Serine/threonine-protein kinase PAK7 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase STK26 Serine/threonine-protein kinase MST4 1 0 0 1 0 0 1
Epigenetic regulator Reader Methyl-lysine/arginine binding protein DNMT3B DNA (cytosine-5)-methyltransferase 3B 2 2 0 0 0 0 0
Enzyme Kinase Protein Kinase NLK Serine/threonine protein kinase NLK 1 0 0 1 0 0 1
Epigenetic regulator Eraser Histone deacetylase HDAC6 Histone deacetylase 6 1 0 0 0 0 0 0
Enzyme Kinase Protein Kinase RPS6KB2 Ribosomal protein S6 kinase 2 1 0 0 1 0 0 1
Membrane receptor Family C G protein-coupled receptor Small molecule receptor (family C GPCR) GABBR1 GABA-B receptor 1 3 3 0 3 0 0 3
Enzyme Kinase Protein Kinase STK17A Serine/threonine-protein kinase 17A 2 0 0 2 0 0 1
Enzyme Kinase Protein Kinase STK39 STE20/SPS1-related proline-alanine-rich protein kinase 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase EPHA6 Ephrin type-A receptor 6 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase TBK1 Serine/threonine-protein kinase TBK1 8 3 0 3 0 0 2
Ion channel Voltage-gated ion channel Voltage-gated sodium channel SCN11A Sodium channel protein type XI alpha subunit 2 1 0 1 0 0 1
Enzyme Kinase Protein Kinase DAPK2 Death-associated protein kinase 2 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase RPS6KA6 Ribosomal protein S6 kinase alpha 6 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase TNIK TRAF2- and NCK-interacting kinase 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase TLK1 Serine/threonine-protein kinase tousled-like 1 1 0 0 1 0 0 1
Epigenetic regulator Eraser Histone deacetylase HDAC9 Histone deacetylase 9 1 0 0 0 0 0 0
Enzyme Kinase Protein Kinase TAOK2 Serine/threonine-protein kinase TAO2 1 0 0 1 0 0 1
Enzyme Lyase n.a. CA14 Carbonic anhydrase XIV 977 416 76 266 1 21 243
Enzyme Kinase Protein Kinase ALK ALK tyrosine kinase receptor 41 14 1 7 0 1 16
Enzyme Transferase n.a. POLI DNA polymerase iota 294 115 23 93 0 5 70
Enzyme Protease Serine protease CELA1 Elastase 1 1 0 0 0 0 0 0
Transporter Primary active transporter ATP-binding cassette ABCG2 ATP-binding cassette sub-family G member 2 146 43 6 35 0 1 35
Epigenetic regulator Reader Plant homeodomain PHF8 Histone lysine demethylase PHF8 3 1 0 0 0 0 1
Enzyme Kinase Protein Kinase CILK1 Serine/threonine-protein kinase ICK 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase AURKC Serine/threonine-protein kinase Aurora-C 2 0 0 1 0 0 1
Ion channel Voltage-gated ion channel Voltage-gated sodium channel SCN8A Sodium channel protein type VIII alpha subunit 9 5 0 3 0 0 2
Epigenetic regulator Eraser Histone deacetylase HDAC5 Histone deacetylase 5 1 0 0 0 0 0 0
Enzyme Kinase Protein Kinase CAMK2A CaM kinase II alpha 8 3 0 3 0 0 2
Enzyme Phosphodiesterase Phosphodiesterase 10 PDE10A Phosphodiesterase 10A 9 7 2 2 0 0 5
Enzyme Kinase Protein Kinase AKT3 Serine/threonine-protein kinase AKT3 2 1 0 1 0 0 1
Enzyme Transferase n.a. POLH DNA polymerase eta 294 115 23 93 0 5 70
Unclassified protein n.a. n.a. PLAA Phospholipase A-2-activating protein 2 2 0 2 0 0 0
Enzyme Lyase n.a. CA5B Carbonic anhydrase VB 76 28 7 15 0 2 22
Enzyme Kinase Protein Kinase STK38L Serine/threonine-protein kinase 38-like 1 0 0 1 0 0 1
Other cytosolic protein n.a. n.a. NISCH Nischarin 2 1 0 1 0 0 1
Enzyme Kinase Protein Kinase SIK3 Serine/threonine-protein kinase SIK3 1 0 0 1 0 0 1
Enzyme Transferase n.a. GSTK1 Glutathione S-transferase kappa 1 7 6 4 2 0 0 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) GPR55 G-protein coupled receptor 55 1 1 1 0 0 0 1
Enzyme Kinase Protein Kinase MAP3K2 Mitogen-activated protein kinase kinase kinase 2 1 0 0 1 0 0 1
Enzyme Kinase Protein Kinase DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B 13 6 0 6 0 0 2
Epigenetic regulator Reader Methyl-lysine/arginine binding protein L3MBTL1 Lethal(3)malignant brain tumor-like protein 1 493 211 72 136 0 16 107
Enzyme Hydrolase n.a. DAGLA Sn1-specific diacylglycerol lipase alpha 3 3 1 2 0 1 0
Enzyme Kinase Protein Kinase MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 1 0 0 1 0 0 1
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HRH3 Histamine H3 receptor 46 21 8 15 0 2 13
Enzyme Kinase Protein Kinase CDC42BPB Serine/threonine-protein kinase MRCK beta 1 0 0 1 0 0 1
Transporter Transmembrane 1-electron transfer carriers n.a. NOX1 NADPH oxidase 1 2 2 1 1 0 1 0
Enzyme Hydrolase n.a. LIPG Endothelial lipase 3 3 1 2 0 1 0
Enzyme Kinase Protein Kinase STK24 Serine/threonine-protein kinase 24 1 0 0 1 0 0 1
Transporter Electrochemical transporter SLC superfamily of solute carriers SLCO1B1 Solute carrier organic anion transporter family member 1B1 526 268 172 126 0 17 124
Epigenetic regulator Writer Histone acetyltransferase NCOA3 Nuclear receptor coactivator 3 10 6 3 4 0 1 1