TCM Prescription: Shuang Teng Jin Gu Tablets



Prescription Description
Prescription IDTCMF7232
Pinyin NameShuang Teng Jin Gu Pian
Chinese Name双藤筋骨片
English NameShuang Teng Jin Gu Tablets
Function Description祛风除湿, 散寒止痛, 活血通络。用于骨性关节炎寒湿阻络证所致的关节疼痛, 沉重, 活动受限, 劳累及受寒后加重等。
IndicationsArthritis, Rheumatoid arthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationBlood, SkeletaMuscle
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH600 Euonymus fortunei 扶芳藤 TCMH600 GBVF1345-11, GBVF1343-11
TCMH1714 Lonicera japonica 忍冬藤 TCMH1714 ITSAI3881-14
TCMH2507 Epimedium brevicornum 淫羊藿 TCMH2507 AY362429
TCMH517 Angelica pubescens 独活 TCMH517 ITSAF170-14
TCMH294 Rhizoma dioscoreae nipponicae 穿山龙 TCMH294
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1310 Enterococcus hirae
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR2B, HTR6, INSR, KDR, MET, MMP12, MMP9, SMAD3, SRC, TEK, XDH 10.4431
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR2B, HTR6, INSR, KDR, MET, MMP12, MMP9, SMAD3, SRC, TEK, XDH 10.4431
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, CSNK2A1, CYP1B1, DRD2, EGFR, F3, FABP3, FLT3, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PGR, PIM1, SMAD3, SRC, TEK, XDH 9.80088
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FABP3, HSD17B2, HTR5A, IGF1R, INSR, MMP2, MMP9, NR3C1, RORC, SRC, TEK, TYR 9.52963
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, HTR5A, IGF1R, INSR, KDR, MMP2, NR3C1, RORC, SMAD3, SRC, TEK, TYR 9.52227
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, HTR2B, HTR5A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, RORC, SMAD3, SRC, TEK, TYR 8.80541
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FLT3, HTR5A, NR3C1, RORC, SRC, TEK, TYR 8.61801
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.02063
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, HTR7, INSR, KDR, MET, SMAD3, SRC, TEK, XDH 7.70982
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, EGFR, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET 7.64763
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 7.64763
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, CYP1B1, DRD2, EGFR, F3, FLT3, GPR35, HSPA1A, HTR2B, HTR6, INSR, KDR, MET, SRC, TEK, XDH 7.58389
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 7.58389
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, RORC, SMAD3, SRC, TEK, XDH 7.58389
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, AR, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, FABP3, FLT3, HTR5A, IGF1R, INSR, MMP2, NR3C1, SMAD3, SRC, TEK 7.58389
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, DRD2, EGFR, F3, FLT3, GPR35, HSPA1A, HTR2B, HTR6, INSR, KDR, MET, MMP12, MMP9, SMAD3, SRC, TEK, XDH 7.56742
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, F3, FLT3, GPR35, HSPA1A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, SRC, TEK, XDH 7.55809
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, RORC, SMAD3, SRC, TEK, TYR, XDH 7.15518
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.07261
[BP] GO:0033993 response to lipid ALPL, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, HTR5A, NR3C1, RORC, SRC, TYR 7.04512
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, HSD17B2, HTR1A, HTR2B, HTR7, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, RORC, SMAD3, SRC, TEK, TYR 6.86553
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.64877
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, HSPA1A, HTR2B, PIM1, TYR, XDH 6.61353
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, RORC, SMAD3, SRC, TEK, XDH 6.46543
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, SMAD3, SRC, TEK 6.35662
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.31589
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.29614
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, RORC, SMAD3, SRC 6.29286
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK, XDH 6.11372
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, DRD2, EGFR, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2B, HTR6, INSR, KDR, MET, MMP12, MMP2, MMP9, SMAD3, SRC, TEK, XDH 6.08468
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP2, NR3C1, NR3C2, NUAK1, PGR, PIM1, RORC, SMAD3, SRC, TEK, TYR, XDH 6.07944
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.04758
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK 6.01852
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CSNK2A1, DRD2, EGFR, F3, FLT3, HTR1A, HTR2B, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK 5.9172
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, HTR5A, INSR, NR3C1, SRC, TEK 5.90559
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SRC 5.8985
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.8985
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.88475
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AURKB, AXL, CA2, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, FUT7, HSD17B2, HTR2B, HTR5A, INSR, KDR, MET, MMP2, MMP9, PGR, PIM1, RORC, SMAD3, SRC, TEK, TYR 5.77347
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK, XDH 5.64655
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.61733
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AR, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, F3, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, HTR1A, HTR2B, HTR5A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NR3C1, NUAK1, RORC, SMAD3, SRC, TEK, TYR 5.59424
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIM1, SMAD3, SRC, TEK, XDH 5.57212
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AR, AXL, CYP1A1, CYP1B1, DRD1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, NR3C1, RORC, SMAD3, SRC 5.56818
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD17B1, HSD17B2 5.56818
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK 5.56499
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.47803
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.43024
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIM1, SMAD3, SRC, TEK 5.40053
[BP] GO:0007210 None HTR1A, HTR2B, HTR5A, HTR6, HTR7 5.39767
[BP] GO:0098664 None HTR1A, HTR2B, HTR5A, HTR6, HTR7 5.39767
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSD17B2, HTR5A, INSR, KDR, MMP9, PGR, PIM1, RORC, SMAD3, SRC, TEK, TYR 5.29172
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, DRD1, EGFR, FLT3, NR3C1, RORC, SRC 5.26534
[BP] GO:0030335 positive regulation of cell migration APP, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.25577
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.18424
[BP] GO:2000147 positive regulation of cell motility APP, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.10741
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, EGFR, F3, INSR, MET, SRC, TEK, XDH 5.09583
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.08393
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, RORC, SMAD3, SRC, TEK 5.0751
[BP] GO:0051272 positive regulation of cellular component movement APP, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.00962
[BP] GO:0003018 None ADORA1, DRD1, EGFR, HTR1A, HTR2B, HTR7, SRC, TEK 4.97902
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.95444
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, GPR35, HTR2B, INSR, MET, SMAD3, SRC 4.94155
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.91755
[BP] GO:0040017 positive regulation of locomotion APP, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.86967
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, EGFR, FABP3, FABP4, FUT7, MET 4.80146
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, DRD2, DUSP3, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, SRC, TEK, XDH 4.78614
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, RORC, SMAD3, SRC 4.71363
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, HCAR2, HSD17B1, HSD17B2, HTR1A 4.69729
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, DRD2, EGFR, FLT3, HTR2B, INSR, KDR, SRC, TEK, XDH 4.68311
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 4.66466
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, DRD2, EGFR, HSPA1A, HTR2B, MMP2, SMAD3, SRC, TEK, TYR 4.60064
[BP] GO:0050678 None AR, EGFR, F3, HTR2B, KDR, MMP12, PGR, SMAD3, TEK, XDH 4.59097
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, F3, FLT3, GPR35, HSPA1A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 4.56346
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, DRD1, EGFR, IGF1R, INSR, MMP2, MMP9, NR3C1, RORC, SRC 4.56346
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DRD1, DRD2, EGFR, HSPA1A 4.55821
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.55821
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2, EGFR 4.53648
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, XDH 4.52897
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, RORC, SMAD3, SRC, TEK, TYR, XDH 4.43139
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, SMAD3, SRC, TEK, TYR 4.41209
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, RORC, SMAD3, SRC, TEK, TYR, XDH 4.35663
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 4.30329
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2B, SRC, TEK 4.26779
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, CA2, CYP1B1, DRD2, EGFR, F3, HCAR2, HSPA1A, HTR2B, KDR, MET, MMP12, MMP9, PIM1, SMAD3, SRC, TEK 4.24207
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, XDH 4.22166
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, DRD1, DRD2, EGFR, FABP3, FABP4, GPR35, HTR2B, INSR, MET, SMAD3 4.22081
[BP] GO:0003013 None ADORA1, DRD1, EGFR, HTR1A, HTR2B, HTR7, SRC, TEK 4.18765
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, EGFR, HCAR2, HTR2B, KDR, SRC 4.16
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, HTR2B, KDR, SRC 4.1525
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, DRD1, DRD2, EGFR, FABP3, FLT3, HTR2B, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 4.14899
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, DRD1, DRD2, EGFR, FABP3, FLT3, HTR2B, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 4.14899
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, DRD1, DRD2, EGFR, HCAR2, HTR2B, INSR, MMP12, SMAD3, SRC 4.14478
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, AR, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 4.13123
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC, TEK 4.12421
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.12421
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, AR, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 4.09147
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, HSPA1A, HTR2B, IGF1R, INSR, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 4.06149
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SRC, TEK 3.9907
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F3, INSR, MET, SRC, TEK 3.97292
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, FABP3, HTR2B, KDR, NR3C1, SRC 3.96535
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.93365
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DRD2, DUSP3, EGFR, F3, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, SMAD3, SRC, TEK, XDH 3.93365
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.93365
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.88052
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, SRC, TEK 3.86083
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.85283
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, HTR1A, TYR 3.84824
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD1, DRD2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, SRC, TEK, TYR 3.83219
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.82104
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, TYR, XDH 3.81621
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.81069
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.78052
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.78052
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, EGFR, GPR35, HCAR2, HSPA1A, HTR1A, HTR2B, INSR, MMP12, MMP9, SMAD3, SRC 3.74618
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, EGFR, FLT3, HTR1A, MET, PIM1, SRC, TEK, TYR 3.73082
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC, TEK 3.70838
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.69474
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.69474
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2B, IGF1R, INSR, KDR, MMP9, SRC, TEK, XDH 3.65708
[BP] GO:0050679 None AR, EGFR, F3, HTR2B, KDR, MMP12, TEK 3.63532
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 3.61859
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, EGFR, HTR1A, INSR, SMAD3 3.60891
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 3.60891
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1, SRC 3.59634
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, DRD1, EGFR, FLT3, IGF1R, INSR, MMP2, NR3C1, SMAD3, SRC 3.5691
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, HTR1A 3.53714
[BP] GO:0007187 None ADORA1, DRD1, DRD2, HTR1A, HTR5A, HTR6, HTR7 3.52381
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DRD1, DRD2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, SRC, TEK, TYR 3.52172
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.49985
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, AR, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, SRC, TEK, XDH 3.47187
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, HTR2B, RORC, SRC, TEK 3.45494
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, RORC, SMAD3, SRC, TEK, TYR, XDH 3.45494
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, DRD1, DRD2, EGFR, F3, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PGR, RORC, SMAD3, SRC, TEK, XDH 3.45494
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, CSNK2A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2B, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 3.45457
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, DRD1, DRD2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, SMAD3, SRC, XDH 3.42685
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DRD2, DUSP3, EGFR, HTR2B, KDR, SRC, TEK 3.41411
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, DRD1, DRD2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, SMAD3, SRC, XDH 3.41411
[BP] GO:0097746 None ADORA1, DRD1, EGFR, HTR1A, HTR2B, HTR7 3.40359
[BP] GO:0035296 None ADORA1, DRD1, EGFR, HTR1A, HTR2B, HTR7 3.40359
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AR, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, DRD1, DRD2, DUSP3, EGFR, F3, FLT3, FUT7, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, TYR, XDH 3.39382
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.39382
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 3.38231
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.38231
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade APP, DRD2, EGFR, HTR2B, KDR, SRC, TEK 3.35881
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2B, SRC, TEK 3.35051
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, EGFR, KDR, NR3C1, SRC 3.34651
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.34651
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, EGFR, HTR7, PGR, RORC, SRC 3.32819
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 3.31557
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, NR3C1, NR3C2, PGR, RORC, SRC 3.3114
[BP] GO:0071383 None AR, EGFR, FLT3, NR3C1, SRC 3.30461
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, GPR35, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, RORC, SMAD3, SRC, TEK, XDH 3.28816
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, GPR35, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIM1, RORC, SMAD3, SRC, TEK, XDH 3.28547
[BP] GO:0050880 None ADORA1, DRD1, EGFR, HTR1A, HTR2B, HTR7 3.28375
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, DRD2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 3.27768
[BP] GO:0035150 None ADORA1, DRD1, EGFR, HTR1A, HTR2B, HTR7 3.26901
[BP] GO:0007193 None ADORA1, DRD2, HTR1A, HTR5A, HTR7 3.2621
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2B, IGF1R, INSR, KDR, MMP9, SRC, TEK, XDH 3.24675
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3 3.22223
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AR, AURKB, DRD1, DRD2, EGFR, F3, FABP3, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PGR, RORC, SMAD3, SRC, TEK, XDH 3.22223
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, HTR1A, TYR 3.21665
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, CBR1, CYP1A1, DRD1, DRD2, EGFR, FABP4, FLT3, FUT7, HTR2B, KDR, MET, MMP2, MMP9, PGR, RORC, SMAD3, SRC, TEK 3.20928
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, DRD1, DRD2, EGFR, F3, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PGR, RORC, SMAD3, SRC, TEK, XDH 3.18692
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, EGFR 3.18247
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, EGFR 3.18247
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, DRD1, DRD2, KDR, SRC 3.17591
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, CA2, CYP1B1, DRD2, EGFR, F3, GPR35, HCAR2, HSPA1A, HTR2B, INSR, KDR, MET, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, XDH 3.16277
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, DRD1, DRD2, EGFR, F3, FABP3, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PGR, RORC, SMAD3, SRC, TEK, XDH 3.15908
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, SRC 3.15181
[BP] GO:0048545 response to steroid hormone ALPL, AR, CA2, EGFR, FLT3, NR3C1, SRC 3.11715
[BP] GO:0097756 None ADORA1, HTR1A, HTR2B, HTR7 3.09716
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, EGFR, F3, FABP4, KDR, MET, MMP12, SMAD3, TEK 3.07363
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3 3.0554
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, EGFR, HCAR2 3.03574
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.03558
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9 3.02188
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, DRD1, DRD2, EGFR, FABP3, GPR35, HTR2B, SMAD3 2.97703
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, DRD2, EGFR, FLT3, HTR2B, INSR, KDR, MMP9, SRC, TEK, XDH 2.97221
[BP] GO:0050714 None ACHE, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 2.93684
[BP] GO:0007188 None ADORA1, DRD1, DRD2, HTR1A, HTR5A, HTR7 2.92468
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 2.90796
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, AR, CSNK2A1, DRD2, EGFR, F3, FLT3, HSPA1A, HTR2B, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 2.87644
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.8617
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, DRD1, DRD2, EGFR, FABP3, HTR2B, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, RORC, SMAD3, SRC 2.84747
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, DRD1, DRD2, GPR35, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, INSR, SRC 2.8468
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2B, IGF1R, INSR, SRC 2.8419
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC 2.83438
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.81803
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, DRD2, EGFR, FLT3, HTR2B, INSR, KDR, MMP9, SRC, TEK, XDH 2.78964
[BP] GO:0009755 hormone-mediated signaling pathway AR, NR3C1, NR3C2, PGR, RORC, SRC 2.77647
[BP] GO:0006939 None DRD1, DRD2, HTR2B, HTR7 2.77342
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2B, IGF1R, INSR, SRC, TEK 2.7653
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.75626
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, AR, CYP19A1, DRD1, DRD2, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, MMP9, SMAD3, SRC, TEK, XDH 2.7542
[BP] GO:0009653 anatomical structure morphogenesis APP, AR, AXL, CA2, CA9, CYP1B1, DRD2, EGFR, HTR2B, INSR, MET, MMP2, SMAD3, SRC, TEK 2.74561
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.74561
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.74561
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.74561
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.74561
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, MMP12, SMAD3, TEK 2.73733
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 2.72811
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD2, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, SRC 2.71676
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, SMAD3, SRC, TEK 2.71195
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APP, AR, AURKB, CA9, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, HCAR2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, RORC, SMAD3, SRC, TEK, XDH 2.70674
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.70472
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2B, IGF1R, INSR, SRC, TEK 2.7038
[BP] GO:0030522 intracellular receptor signaling pathway AR, NR3C1, PGR, PIM1, RORC, SRC 2.69397
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.65366
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.65366
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, DRD2, EGFR, HCAR2, HTR2B, MMP12, SMAD3, SRC 2.64842
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.64842
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DRD2, EGFR, SMAD3 2.64842
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, SMAD3, SRC, TEK 2.64532
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, CYP19A1, CYP1A1, DRD1, EGFR, HSD17B2, INSR, MMP2, MMP9, PGR, SRC 2.64077
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, AR, DRD2, EGFR, F3, FLT3, HSPA1A, HTR2B, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 2.63465
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CYP1A1, DRD2, DUSP3, EGFR, INSR, SRC 2.63089
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, AR, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 2.63089
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.62474
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.62474
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.62474
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APP, AR, AURKB, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, HCAR2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, RORC, SMAD3, SRC, TEK, XDH 2.62474
[BP] GO:0060748 None AR, PGR 2.60393
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.60393
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, DRD2, DUSP3, EGFR, FABP4, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, RORC, SMAD3, SRC, XDH 2.57768
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.56165
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC 2.54697
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AR, AURKB, DRD2, EGFR, F3, FLT3, HSPA1A, HTR2B, INSR, MET, MMP9, SMAD3, SRC, TEK, XDH 2.54681
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 2.54681
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, RORC 2.54681
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.54681
[BP] GO:0002009 morphogenesis of an epithelium AR, CA2, CA9, EGFR, MET, SMAD3, SRC 2.52498
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR 2.49041
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET 2.4803
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DRD1, EGFR, IGF1R, INSR, MMP2, SRC 2.46633
[BP] GO:0098771 inorganic ion homeostasis APP, CA12, CA2, CA7, DRD1, DRD2, EGFR, GPR35, HTR2B, SMAD3 2.46633
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, DRD2, EGFR, HCAR2, HTR2B, MMP12, SMAD3, SRC 2.45981
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, DRD1, DRD2, EGFR, FABP3, HTR2B, IGF1R, INSR, MET, MMP12, NR3C1, PGR, RORC, SMAD3, SRC 2.45134
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, SMAD3, SRC, TEK 2.45031
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.44485
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, FABP4, HSPA1A, MMP12, MMP2, SMAD3, SRC, TEK 2.43789
[BP] GO:0032989 cellular component morphogenesis APP, AR, AXL, DRD2, EGFR, MET, SRC, TEK 2.43114
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2B, IGF1R, INSR, SRC 2.43082
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2B, SRC, TEK 2.41154
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.38379
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.38379
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.38379
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2 2.37819
[BP] GO:0050795 None ADORA1, DRD2, HTR1A, HTR2B 2.37819
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, SMAD3, SRC, XDH 2.37021
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.35445
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.3531
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.3531
[BP] GO:0051894 None KDR, SMAD3, TEK 2.34102
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.34102
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, DRD2, EGFR, HCAR2, HTR2B, MMP12, SMAD3, SRC 2.34102
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.32443
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.3183
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3 2.30824
[BP] GO:0050927 None F3, KDR, SMAD3 2.29594
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, EGFR, HCAR2, HTR1A, HTR2B, MMP12, SRC 2.28911
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CYP1A1, DRD1, EGFR, PGR, SRC 2.2819
[BP] GO:0001936 None F3, HTR2B, KDR, TEK, XDH 2.28159
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DRD1, EGFR, IGF1R, INSR, MMP2, SRC 2.27159
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.25425
[BP] GO:0050926 None F3, KDR, SMAD3 2.25425
[BP] GO:1903393 None KDR, SMAD3, TEK 2.25425
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.22226
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, CYP1B1, DRD2, FABP3, HSPA1A, SMAD3, XDH 2.1921
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.18758
[BP] GO:0021853 None DRD1, DRD2 2.16515
[BP] GO:0010641 None F3, SRC 2.16515
[BP] GO:1904936 None DRD1, DRD2 2.16515
[BP] GO:0042321 None ADORA1, DRD2 2.16515
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, CYP1B1, DRD1, DRD2, EGFR, HTR2B, HTR5A, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK 2.15128
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.13002
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.13002
[BP] GO:0002791 None ACHE, ADORA1, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 2.13002
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, DRD1, DRD2, EGFR, HSPA1A, IGF1R, INSR, MET, MMP12, NR3C1, PGR, RORC, SMAD3, SRC 2.13002
[BP] GO:0042310 None HTR1A, HTR2B, HTR7 2.13002
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, RORC, SMAD3, SRC, TEK, XDH 2.13002
[BP] GO:0019932 second-messenger-mediated signaling DRD1, DRD2, EGFR, HTR2B, HTR5A, KDR 2.10765
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, SMAD3, SRC, XDH 2.09881
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, NR3C1, PGR, SRC 2.09811
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.09695
[BP] GO:0051246 regulation of protein metabolic process ADORA1, APP, AR, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 2.09615
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.09615
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.09615
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, RORC, SMAD3, SRC, TEK, XDH 2.09565
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.0839
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, DRD2, EGFR, HCAR2, HTR1A, HTR2B, MMP12, SRC 2.07097
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, AR, DRD2, EGFR, FLT3, HTR2B, INSR, KDR, MMP9, SRC, TEK, XDH 2.06655
[BP] GO:1901890 None KDR, SMAD3, TEK 2.06136
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.06136
[BP] GO:0001659 None ADORA1, DRD1, DRD2 2.06136
[BP] GO:0003008 None ADORA1, AKR1B1, APP, CYP1B1, DRD1, DRD2, EGFR, HTR1A, HTR2B, HTR7, INSR, SRC, TEK, TYR 2.05701
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, RORC, SMAD3, SRC, TEK, XDH 2.05422
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.0513
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSPA1A, HTR1A, MMP2, MMP9, NUAK1, SMAD3, SRC, TEK 2.05036
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, INSR, SRC, TEK 2.05036
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, CYP19A1, EGFR, HSD17B2, INSR, PGR, SRC 2.05036
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, TYR 2.03701
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.03701
[BP] GO:0021843 None DRD1, DRD2 2.03689
[BP] GO:1990535 None APP, INSR 2.03689
[BP] GO:0021830 None DRD1, DRD2 2.03689
[BP] GO:0021826 None DRD1, DRD2 2.03689
[BP] GO:0031960 response to corticosteroid ALPL, EGFR, FLT3, NR3C1, SRC 2.03358
[BP] GO:0048729 tissue morphogenesis AR, CA2, CA9, EGFR, MET, SMAD3, SRC 2.01821
[BP] GO:0043269 regulation of ion transport ADORA1, APP, CA2, CA7, DRD1, DRD2, GPR35, HTR1A, MMP9 2.0157
[BP] GO:0071396 cellular response to lipid AR, AXL, EGFR, FLT3, NR3C1, RORC, SRC 2.01297
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.00384
[BP] GO:0106027 None APP, IGF1R, INSR 2.00384
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3 2.00384
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, DRD1, DRD2, F3, FLT3, GPR35, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 5.11142
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, PIM1, SMAD3, SRC, TEK 4.44115
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, DRD1, DRD2, FLT3, GPR35, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 4.14478
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, APP, AXL, CA2, CA4, CA9, DRD1, DRD2, DUSP3, EGFR, F3, FLT3, GPR35, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SRC, TEK 4.09628
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, EGFR, F3, FLT3, FUT7, GPR35, HCAR2, HSD17B2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, NR3C2, PGR, PIM1, SMAD3, SRC, TEK, TYR 4.09628
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DUSP3, EGFR, F3, FLT3, FUT7, GPR35, HCAR2, HSD17B2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, NR3C2, SRC, TEK, TYR 3.12285
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.57676
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, INSR, SRC 2.27532
[MF] GO:0046914 transition metal ion binding ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, RORC, SMAD3, TYR, XDH 12.6464
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, EGFR, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, HTR1A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, RORC, SMAD3, SRC, TEK, TYR, XDH 12.3116
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.0667
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, DRD1, DRD2, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, RORC, TEK 8.95629
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, DRD1, DRD2, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, RORC, TEK 7.94635
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, DRD1, DRD2, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, RORC, SMAD3, TEK 7.89848
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, DRD1, DRD2, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, RORC, TEK 7.70982
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.58389
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, HTR1A, HTR2B, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, RORC, SMAD3, TYR, XDH 7.15518
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F3, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, SRC, TEK, TYR, XDH 6.99813
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.86553
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.8237
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.4702
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 6.04758
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 6.04758
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DRD1, DRD2, EGFR, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 5.92319
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, HTR1A, HTR2B, HTR5A, HTR7 5.77347
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.70186
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, RORC, SMAD3 5.64342
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.56818
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.45547
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, IGF1R, INSR, NR3C1 5.40668
[MF] GO:0004993 None HTR1A, HTR2B, HTR5A, HTR6, HTR7 5.39767
[MF] GO:0099589 None HTR1A, HTR2B, HTR5A, HTR6, HTR7 5.39767
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 5.1259
[MF] GO:0008227 None DRD2, HTR1A, HTR2B, HTR5A, HTR6, HTR7 5.0751
[MF] GO:0043176 None HTR1A, HTR2B, HTR5A, HTR7 5.05587
[MF] GO:0051378 None HTR1A, HTR2B, HTR5A, HTR7 5.05587
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 4.89069
[MF] GO:0030594 None DRD1, DRD2, HTR1A, HTR2B, HTR5A, HTR6, HTR7 4.79451
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, TYR, XDH 4.71363
[MF] GO:0099528 None HTR1A, HTR2B, HTR5A, HTR6, HTR7 4.51509
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.45292
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.3959
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.19835
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.18765
[MF] GO:0005496 steroid binding AR, HSD17B1, NR3C1, NR3C2, PGR, RORC 4.16606
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2B, HTR5A, HTR7 3.93365
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 3.93365
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.70684
[MF] GO:0003707 steroid hormone receptor activity AR, NR3C1, NR3C2, PGR, RORC 3.70241
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, RORC, SMAD3, TYR, XDH 3.68873
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.51303
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.45899
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.36005
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.29593
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 3.22223
[MF] GO:0008389 None CYP2A13, CYP2A6 2.99195
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, SMAD3, SRC 2.79712
[MF] GO:0097159 organic cyclic compound binding ADORA1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, EGFR, FLT3, HSD17B1, HSPA1A, HTR1A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NR3C2, NUAK1, PGR, PIM1, RORC, SMAD3, SRC, TEK, XDH 2.76662
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.71512
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.68064
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, SRC, XDH 2.64014
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.46633
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, SMAD3, SRC 2.41247
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.39812
[MF] GO:0051425 None APP, INSR 2.3531
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.31926
[MF] GO:0008289 lipid binding AR, AXL, F3, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, RORC 2.31695
[MF] GO:0043559 insulin binding IGF1R, INSR 2.16515
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.13002
[MF] GO:1901363 heterocyclic compound binding ADORA1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FLT3, HSD17B1, HSPA1A, HTR1A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NR3C2, NUAK1, PGR, PIM1, RORC, SMAD3, SRC, TEK, XDH 2.13002
[MF] GO:0004930 None ADORA1, ADORA3, DRD1, DRD2, GPR35, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7 2.11214
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CSNK2A1, DUSP3, EGFR, F3, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, SRC, TEK 2.03701
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.03689
[MF] GO:0004064 arylesterase activity CA1, CA2 2.03689


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.6297
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.19
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR6, HTR7, GPR35, ADORA3, HTR2B, ADORA1, HTR1A, DRD1, NR3C1, HTR5A, DRD2 7.2752
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.8877
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR6, HTR7, ALOX5, HTR2B, HTR1A, HTR5A 5.8011
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.0786
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.6171
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 5.3441
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.4674
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.4227
Pathways in cancer_Homo sapiens_hsa05200 AR, SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 4.3093
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.3553
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, INSR, KDR, TEK, MET, EGFR, IGF1R 4.1037
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.8167
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 3.8505
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, TYR, CYP19A1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 3.6682
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, DRD1, HTR5A, EGFR 3.7361
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, DRD1, DRD2, EGFR 4.0722
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, HTR6, ADORA1, HTR1A, DRD1, DRD2 3.5373
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1, F3 2.7102
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.3868
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.5648
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.697
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3478
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7263
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.3868
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.25
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR 1.9905
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.2223
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1909
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2179
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.2457
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9905
Prostate cancer_Homo sapiens_hsa05215 AR, EGFR, IGF1R 1.9602
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.9446
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.2134
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.6332
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.4981
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.4693
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.3491
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 0.9855
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B 1.0612
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1196
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, IGF1R 1.0612
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0801
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3491
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.0986
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3808
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.324
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1001
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9435
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8604
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9435
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.937
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.9183
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 0.8941
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1996
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.852
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3196
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.852
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.852
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.852
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8471
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3613
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8083
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.324
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6611
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.2912
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.7416
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6358
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5 1.3464
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.248
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.4878
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3126
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3548
Purine metabolism_Homo sapiens_hsa00230 XDH 0.348
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3385
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3477
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.348
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3548
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3705
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR 0.3789
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3779
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3382
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4132
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.4038
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR, NR3C2 1.64
Hepatitis C_Homo sapiens_hsa05160 EGFR 0.4132
Platelet activation_Homo sapiens_hsa04611 SRC 0.4322
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5214
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.4299
Insulin resistance_Homo sapiens_hsa04931 INSR 0.4589
Axon guidance_Homo sapiens_hsa04360 MET 0.425
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4589
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4406
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4589
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4787
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4717
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4787
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4901
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.49
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4942
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.5171
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5071
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5071
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5167
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5067
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5456
Peroxisome_Homo sapiens_hsa04146 XDH 0.5171
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5465
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5445
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5278
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5334
Bile secretion_Homo sapiens_hsa04976 CA2 0.5478
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5674
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5659
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5704
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5867
Shigellosis_Homo sapiens_hsa05131 SRC 0.5688
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5782
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8312
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6092
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6293
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6117
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6975
Malaria_Homo sapiens_hsa05144 MET 0.6436
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6469
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.787
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0007
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7602
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8356
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7602
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8116
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.3641
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8404
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8083
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8356
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0208


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)