TCM Prescription: Xi Ling Jie Du Pills



Prescription Description
Prescription IDTCMF5758
Pinyin NameXi Ling Jie Du Wan
Chinese Name犀羚解毒丸
English NameXi Ling Jie Du Pills
Function Description感冒, 风温
IndicationsCommon cold disorder, Common cold
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
Human Tissues Associated with IndicationLung, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH1562 Arctium lappa 牛蒡子 TCMH1562 ITSAI1776-14
TCMH1142 Schizonepetae spica 荆芥穗 TCMH1142
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
TCMH1127 Lonicera japonica 金银花 TCMH1127 ITSAI3881-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH420 Lophatherum gracile 淡竹叶 TCMH420 GBVY2724-14, GBVT2442-13
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH2230 Rhinoceros unicornis 犀角 TCMH2230
TCMH1997 Bubalus bubalis 水牛角 TCMH1997 GBMA0080-06
TCMH1294 Cornu saigae tataricae 羚羊角 TCMH1294
TCMH183 Dryobalanops aromatica 冰片 TCMH183 GBVK4926-11
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT796 PCNA Proliferating cell nuclear antigen Unclassified P12004
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT864 THRA Thyroid hormone receptor alpha Nuclear receptor P10827
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1195 Streptococcus pasteurianus
TCMT1196 Salmonella
TCMT1197 Shigella sp.
TCMT1198 Serratia marcescens
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1333 Human rhinovirus 1A
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, ESR1, ESRRA, FABP3, GSK3B, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, MMP2, MMP9, NR1H4, NR3C1, PPARA, PTGS2, RORC, SRC, TYR 13.3054
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TYR, XDH 12.6165
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, NR1H4, NR3C1, PPARA, PTGS2, RORC, SRC, TYR 12.4881
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SRC, THRA, THRB 12.4881
[BP] GO:0042221 response to chemical ABCB1, ADRA2A, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, NR1H4, NR3C1, PPARA, PTGS2, RORC, SRC, TERT, TYR 11.9956
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NR1H4 11.2888
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SRC, THRA, THRB 11.079
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, IDO1, NR1H4, NR3C1, PTGS2, RORC, SRC, TYR 11.0158
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PGR, PIM1, PPARA, RORC, SRC, THRA, THRB 10.8484
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, NR1H4, PPARA, PTGS2 10.8062
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, ESR1, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MET, NR1H4, PPARA, PTGS2, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 10.7863
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 10.7326
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 10.6842
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, ESR1, ESRRA, FABP3, FLT3, GSK3B, HSD11B2, IGF1R, KIT, MMP2, NR1H4, NR3C1, PPARA, PTGS2, SRC 10.1845
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DNMT1, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, IDO1, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PGR, PIM1, PTGS2, SRC, TERT, XDH 10.1671
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 10.1033
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TYR, XDH 9.78321
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TYR, XDH 9.76003
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, GSK3B, HMGCR, KDR, KIT, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 9.32567
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, GSK3B, HMGCR, KDR, KIT, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 9.29337
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 9.17304
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 9.011
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, FABP3, FUT7, GBA2, HMGCR, IDO1, NR1H4, PIM1, PPARA, PTGS2, TYR, XDH 8.93862
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TYR, XDH 8.88167
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 8.88167
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 8.72685
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 8.66571
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, GSK3B, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 8.49427
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FLT3, HSD11B2, NR3C1, PTGS2, RORC, SRC, TYR 8.35833
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GSK3B, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 8.27261
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DYRK1A, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GSK3B, HMGCR, HSD11B1, HSD17B2, KDR, KIT, MET, MMP2, MMP9, PGR, PIM1, PPARA, PTGS2, RORC, SRC, TERT, THRA, THRB, TNKS2, TYR 8.19166
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, NR3C1, PPARA, PTGS2, SRC 8.16519
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, MMP9, NR1H4, NR3C1, PTGS2, RORC, SRC, TERT 8.16519
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, GSK3B, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT 8.04195
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, GSK3B, HMGCR, KDR, KIT, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.99108
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, THRA, XDH 7.99018
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PIM1, PTGS2, PTPN1, SRC, TERT, THRA, XDH 7.96981
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, GSK3B, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PIM1, PTGS2, PTPN1, SRC, TERT 7.9342
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, ESR1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, NR1H4, NR3C1, PTGS2, RORC, SRC 7.65957
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9, DHFR 7.33394
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, GSK3B, HMGCR, IDO1, KDR, KIT, MET, MMP12, MMP2, MMP9, NR1H4, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.28239
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GSK3B, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 7.28239
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NR1H4 7.10934
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.05095
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AR, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS2, TERT 6.97734
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, DYRK1A, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, NR1H4, PPARA, PTGS2, PTPN1, SRC, TERT, THRA, TNKS, TNKS2, XDH 6.91746
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ADRA2A, APP, CDK6, CYP19A1, DHFR, DYRK1A, ESR1, F3, FABP4, GSK3B, HMGCR, IDO1, IGF1R, MET, MMP12, MMP2, NR1H4, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 6.87119
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, F3, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, SRC, TERT, THRA, TNKS, TNKS2, XDH 6.86598
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.76676
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PTGS2, SRC, TERT 6.76231
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, F3, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, SRC, TERT, THRA, TNKS, TNKS2, XDH 6.7307
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APP, AR, AURKB, BCL2, CSNK2A1, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 6.71893
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MMP9, NR1H4, PIM1, PTGS2, PTPN1, SRC, TERT, THRA, XDH 6.65579
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, THRA, THRB, TNKS2, TYR 6.61447
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, NR1H4, NR3C1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, TYR 6.5151
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MMP9, NR1H4, PIM1, PTGS2, PTPN1, SRC, TERT 6.45782
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DAO, DHFR, GBA2, HMGCR, NR1H4, TYR 6.44033
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.36641
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DYRK1A, ESR1, ESRRA, ESRRB, FLT3, GBA2, GSK3B, HSD11B1, HSD17B2, KDR, KIT, MMP9, PGR, PIM1, PPARA, PTGS2, RORC, SRC, THRA, TYR 6.28126
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, HMGCR, KIT, NR1H4, PPARA, PTGS2, RORC, SRC, THRA 6.14946
[BP] GO:0022414 reproductive process ADRA2C, AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, IDO1, KIT, MMP2, MMP9, PGR, PTGS2, SRC, THRA, THRB 6.11979
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, ESR1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, MMP9, NR1H4, NR3C1, PTGS2, PTPN1, RORC, SRC, TERT 6.05333
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, GSK3B, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, PPARA, PTGS2, PTPN1, SRC, TERT, THRA 6.05047
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APP, AR, AURKB, BCL2, CSNK2A1, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, NR1H4, NR3C1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 5.97367
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.8543
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PTGS2, PTPN1, SRC, XDH 5.75739
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CDK6, HMGCR, KDR, NR1H4, PTGS2, SRC, TNKS, TNKS2 5.74789
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, PIM1, SRC 5.74331
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, KIT, PPARA, SRC, THRA, TYR 5.72108
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CDK6, CYP1B1, DNMT1, ESR1, GSK3B, IGF1R, MMP2, MMP9, NR1H4, NR3C1, PTGS2, RORC, SRC 5.70811
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AXL, BCL2, CYP1B1, F3, FLT3, HMGCR, KDR, KIT, MET, PTGS2, PTPN1, SRC, XDH 5.60822
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.48589
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, ESR1, GSK3B, KIT, PGR, PPARA, RORC, SRC 5.30171
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AR, AURKB, CSNK2A1, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GSK3B, HMGCR, IGF1R, KDR, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 5.28552
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, GSK3B, HMGCR, IDO1, KDR, KIT, MET, MMP12, MMP9, NR1H4, PIM1, PTGS2, SRC, TERT, THRA, THRB, TNKS2, XDH 5.23451
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 5.18583
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DAO, DHFR, DYRK1A, ESR1, F3, FLT3, FUT7, GBA2, GSK3B, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 5.18583
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, AR, BCL2, DYRK1A, ESR1, ESR2, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, SRC, TERT, XDH 5.18369
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, AR, BCL2, DYRK1A, ESR1, ESR2, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, SRC, TERT, XDH 5.16594
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GSK3B, HMGCR, IGF1R, MET, MMP9, NR1H4, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 5.16537
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, FABP3, FABP4, FUT7, GBA2, GSK3B, IDO1, MMP1, MMP12, MMP2, MMP9, SRC, XDH 5.10377
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DHFR, FABP3, HMGCR, HSD11B2, KDR, NR3C1, PTGS2, SRC 5.08975
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, ESR2, F3, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, SRC, TERT, THRA, TNKS, TNKS2, XDH 5.07111
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.02907
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, HMGCR, KIT, MET, PPARA, PTGS2 4.99419
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GSK3B, HMGCR, KDR, KIT, MET, MMP2, MMP9, PGR, PTGS2, RORC, SRC, TERT, THRA, THRB 4.93579
[BP] GO:0051172 None ADRA2A, APP, AR, AURKB, CSNK2A1, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HMGCR, IGF1R, MMP12, MMP9, NR1H4, NR3C1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 4.88324
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, FUT7, GBA2, GSK3B, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TYR, XDH 4.88324
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, HMGCR, KDR, KIT, MMP9, NR1H4, PTGS2, PTPN1, SRC, XDH 4.88324
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, HMGCR, KDR, KIT, MMP9, NR1H4, PTGS2, PTPN1, SRC, XDH 4.88324
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.85472
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, AR, BCL2, CDK6, CYP19A1, DYRK1A, ESR1, ESR2, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, NR1H4, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 4.85472
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 4.8457
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 4.79102
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.78487
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.77382
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APP, AR, DNMT1, ESR1, FLT3, GSK3B, IGF1R, KIT, MMP2, NR1H4, NR3C1, PTGS2, SRC 4.77382
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, PTGS2, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2 4.65468
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRA2C, APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HMGCR, IDO1, KDR, KIT, MET, MMP12, MMP9, NR1H4, PIM1, PTGS2, SRC, TERT 4.6407
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, GSK3B, MET, MMP9, PPARA, SRC, TERT 4.58172
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, RORC, SRC 4.51416
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 4.51416
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 4.50426
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.43331
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, DNMT1, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2 4.43331
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.37628
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, FLT3, HSD11B2, NR3C1, PTGS2, SRC 4.36455
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 4.35572
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, DHFR, ESR1, ESR2, F3, FLT3, GSK3B, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, XDH 4.34601
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2 4.33335
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DHFR, ESR1, ESR2, F3, FABP4, FLT3, GSK3B, HMGCR, IGF1R, KIT, MET, MMP9, NR1H4, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 4.3086
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.29869
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, F3, FLT3, GSK3B, HMGCR, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 4.28934
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 4.27188
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DHFR, DNMT1, FABP3, FLT3, GSK3B, HSD11B2, IGF1R, MMP2, NR1H4, PPARA, PTGS2, SRC, TYR 4.24142
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, ESRRB, FLT3, HMGCR, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 4.22249
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, PTGS2, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2 4.22249
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.19002
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HMGCR, HSD11B2, KIT, MMP2, PPARA, PTGS2, SRC, TERT, THRA, TYR 4.14415
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2 4.12243
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DHFR, DYRK1A, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 4.09138
[BP] GO:0051094 positive regulation of developmental process ADRA2C, APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HMGCR, IDO1, KDR, KIT, NR1H4, PIM1, PTGS2, SRC, TERT, THRA 4.09138
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, F3, FLT3, GSK3B, HMGCR, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 4.08677
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.04399
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2, TERT 4.03345
[BP] GO:0050793 regulation of developmental process ADRA2C, APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, GSK3B, HMGCR, IDO1, KDR, KIT, NR1H4, PIM1, PPARA, PTGS2, RORC, SRC, TERT, THRA, TNKS2, XDH 4.03275
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGS2, TERT 4.02772
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, NR1H4, PPARA, PTGS2, SRC 4.01833
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, DNMT1, FABP3, HSD17B2, KDR, MMP2, NR1H4, PTGS2, SRC 3.9992
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, ESR1, F3, FABP4, FLT3, GSK3B, HMGCR, IGF1R, KIT, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 3.9992
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR, SRC 3.98509
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, NR1H4, SRC 3.95132
[BP] GO:0045934 None ADRA2A, AR, AURKB, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, MMP12, NR1H4, NR3C1, PPARA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2 3.9504
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, KIT, PGR, PTGS2, SRC 3.94248
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 3.92865
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DHFR, DNMT1, FABP3, FLT3, GSK3B, HSD11B2, IGF1R, MMP2, NR1H4, PPARA, PTGS2, SRC, TYR 3.88949
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, NR1H4, PPARA 3.88949
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 3.8863
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, APP, AR, FLT3, HMGCR, KDR, KIT, PTPN1, SRC, XDH 3.88337
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, AR, BCL2, DYRK1A, ESR1, ESR2, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, SRC, TERT, XDH 3.88302
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 3.87061
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, NR1H4, PPARA, PTGS2, PTPN1, SRC, XDH 3.86448
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, FLT3, HMGCR, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 3.84548
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DYRK1A, ESR1, HMGCR, IGF1R, MET, MMP9, NR1H4, PTGS2, PTPN1, SRC, XDH 3.84491
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, NR1H4, PPARA, PTGS2, PTPN1, SRC, XDH 3.81324
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DHFR, DYRK1A, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 3.80798
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, GSK3B, MET, MMP9, PPARA, SRC, TERT, TNKS 3.80548
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, DNMT1, DYRK1A, FLT3, HMGCR, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 3.78024
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 3.78024
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, IDO1 3.76364
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.74479
[BP] GO:0010629 None APP, AR, AURKB, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, KDR, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SRC, TERT, THRA, THRB, XDH 3.71456
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, GBA2, IDO1, NR1H4, PIM1, PPARA, PTGS2, TYR 3.6871
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, ESRRB, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 3.66811
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, HMGCR, SRC, TNKS, TNKS2 3.63645
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CYP1A1, ESR1, KIT, PGR, PTGS2, SRC, THRA, THRB 3.59684
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, KIT, MET, PIM1, SRC, TYR 3.58863
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTGS2 3.58225
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.55454
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.53477
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.51882
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 3.51295
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, AOX1, APP, AR, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, NR1H4, NR3C1, NR3C2, PGR, PPARA, PTGS2, RORC, TERT, THRA, THRB, TYR, XDH 3.45822
[BP] GO:0009889 regulation of biosynthetic process ADORA3, ADRA2A, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DHFR, DNMT1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GSK3B, HMGCR, IGF1R, KDR, KIT, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2 3.45822
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, NR3C1, PTGS2, SRC 3.45822
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 3.45685
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, APP, AXL, BCL2, CA2, CA7, CYP19A1, GSK3B, HMGCR, MMP12, MMP9, NR1H4, PPARA, PTGS2, PTPN1, SRC, TERT, THRA 3.45238
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, ADRA2C, APP, AR, BCL2, CSNK2A1, GSK3B, HMGCR, MMP12, NR1H4, PTGS2, PTPN1, SRC, TERT, THRA 3.44737
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, IDO1, NR1H4, PPARA, PTGS2 3.4057
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, BCL2, DNMT1, ESR1, GSK3B, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 3.37004
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.36923
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.36923
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, CYP3A4, DAO, DHFR, HMGCR, TYR 3.34955
[BP] GO:0050730 None ADORA1, ADRA2A, ADRA2C, APP, FLT3, KIT, PTPN1, SRC 3.33515
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, ADRA2C, APP, CA2, GSK3B, HMGCR, MMP12, NR1H4, PTGS2, PTPN1, SRC, THRA 3.32062
[BP] GO:2000026 regulation of multicellular organismal development ADRA2C, APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, F3, GSK3B, HMGCR, IDO1, KDR, KIT, NR1H4, PIM1, PTGS2, SRC, TERT, XDH 3.30861
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TYR, XDH 3.29699
[BP] GO:0051051 negative regulation of transport ADORA1, ADRA2A, ADRA2C, APP, BCL2, GSK3B, HMGCR, MMP9, NR1H4, PTGS2, THRA 3.28529
[BP] GO:0007176 None ADORA1, ADRA2A, ADRA2C, APP 3.26455
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, GBA2, IDO1, NR1H4, PIM1, PPARA, PTGS2, TYR 3.24038
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 3.24038
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, APP, AR, FLT3, HMGCR, IGF1R, KDR, KIT, PTPN1, SRC, XDH 3.21473
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.21131
[BP] GO:0006940 None ADORA1, ADRA2A, ADRA2C, KIT, PTGS2 3.19292
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, ADRA2C, FLT3, KIT, PTPN1, SRC 3.19251
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, APP, AXL, BCL2, CA2, CYP19A1, GSK3B, MMP12, NR1H4, PTGS2, SRC, TERT 3.16812
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, GBA2, IDO1, NR1H4, PIM1, PPARA, PTGS2, TYR 3.15919
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.14989
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.14989
[BP] GO:0030154 cell differentiation ALPL, AR, AXL, BCL2, CBR1, CDK6, CYP1A1, ESR1, FABP4, FLT3, FUT7, GSK3B, HMGCR, KDR, KIT, MMP2, MMP9, PTGS2, RORC, THRA, THRB 3.13585
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 3.08618
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR, IDO1 3.07939
[BP] GO:0010628 positive regulation of gene expression APP, AR, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GSK3B, KIT, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SRC, TERT, THRA, THRB, TNKS 3.03987
[BP] GO:1901362 None AKR1B1, AR, CSNK2A1, CYP19A1, CYP3A4, DAO, DHFR, DNMT1, ESR1, ESR2, ESRRA, ESRRB, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, NR1H4, NR3C1, NR3C2, PGR, PPARA, PTGS2, RORC, TERT, THRA, THRB, TYR 3.03225
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.02899
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.02899
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, NR1H4, SRC 3.00082
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, NR1H4, SRC, TNKS 2.98738
[BP] GO:0051253 None AR, AURKB, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, MMP12, NR1H4, NR3C1, PPARA, RORC, SRC, TERT, THRA, THRB 2.97758
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, FABP3, FABP4, FUT7, GBA2, GSK3B, IDO1, XDH 2.97593
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR 2.97593
[BP] GO:0045893 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SRC, TERT, THRA, THRB, TNKS 2.97593
[BP] GO:1903508 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SRC, TERT, THRA, THRB, TNKS 2.97593
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DHFR, DYRK1A, GSK3B, HMGCR, IGF1R, MET, PTGS2, PTPN1, TERT, XDH 2.97593
[BP] GO:1902680 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SRC, TERT, THRA, THRB, TNKS 2.97593
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GSK3B, HSD11B2, IGF1R, PPARA, PTGS2, SRC 2.97593
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, NR1H4, PPARA 2.96291
[BP] GO:0061097 None ADORA1, ADRA2A, ADRA2C, APP, PTPN1 2.96291
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, ADRA2C, APP, AURKB, BCL2, CDC25B, DHFR, ESR1, F3, FLT3, GSK3B, KIT, PTPN1, SRC, TERT, TNKS, XDH 2.94507
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, ADRA2C, APP, AURKB, CDC25B, FABP4, FLT3, GSK3B, HMGCR, IGF1R, KIT, PTPN1, SRC, TNKS 2.94405
[BP] GO:0031326 regulation of cellular biosynthetic process ADORA3, ADRA2A, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DHFR, DNMT1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GSK3B, IGF1R, KIT, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2 2.9377
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2, TERT 2.93588
[BP] GO:0045741 None ADORA1, ADRA2A, ADRA2C 2.93588
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, KIT, SRC 2.92441
[BP] GO:0071396 cellular response to lipid AR, AXL, CDK6, ESR1, FLT3, NR1H4, NR3C1, RORC, SRC 2.92228
[BP] GO:0022602 ovulation cycle process BCL2, ESR1, KIT, PGR, SRC 2.91932
[BP] GO:0045742 None ADORA1, ADRA2A, ADRA2C, MMP9 2.90461
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, ESR1, F3, FABP4, HMGCR, IDO1, KDR, MET, MMP12, NR1H4, PPARA, PTGS2 2.88346
[BP] GO:0008050 None THRA, THRB 2.88346
[BP] GO:0009115 None AOX1, XDH 2.88346
[BP] GO:0000122 None AR, AURKB, DNMT1, ESR1, ESR2, ESRRA, MMP12, NR1H4, NR3C1, PPARA, RORC, THRA, THRB 2.88105
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, GSK3B, TNKS 2.88007
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, NR1H4, PTGS2, SRC 2.865
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.84713
[BP] GO:1901186 None ADORA1, ADRA2A, ADRA2C, MMP9 2.83242
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KDR, NR3C1, PTGS2, SRC 2.81688
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, DNMT1, DYRK1A, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.78085
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, NR3C1, PTGS2 2.76616
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, KIT, PTGS2 2.76243
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.75591
[BP] GO:0051254 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SRC, TERT, THRA, THRB, TNKS 2.74376
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MMP9, PTGS2, PTPN1, SRC, TERT 2.72914
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, DYRK1A, GSK3B, TNKS 2.7212
[BP] GO:0042058 None ADORA1, ADRA2A, ADRA2C, APP, MMP9 2.69805
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCL2, CDK6, CYP1B1, FABP3, IDO1, PTGS2, TERT, XDH 2.69542
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS2 2.68694
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, NR1H4, PTGS2, SRC 2.68694
[BP] GO:0070201 None ACHE, ADRA2A, ADRA2C, APP, BCL2, GSK3B, HMGCR, MMP12, NR1H4, PTGS2, PTPN1, SRC, THRA 2.68694
[BP] GO:0061098 None ADORA1, ADRA2A, ADRA2C, PTPN1 2.68549
[BP] GO:0019219 regulation of nucleobase-containing compound metabolic process ADORA3, ADRA2A, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP4, IGF1R, KIT, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2 2.68285
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, KIT, NR1H4, PIM1 2.6809
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.6809
[BP] GO:0006357 None APP, AR, AURKB, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, KIT, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, TERT, THRA, THRB, TNKS 2.67768
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, NR1H4, SRC, TERT 2.67573
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, KIT, PTGS2 2.64842
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, KIT, PTGS2 2.64842
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DNMT1, GSK3B, IGF1R, MMP2, NR1H4, PTGS2, SRC 2.62915
[BP] GO:0045944 None APP, AR, ESR1, ESRRA, ESRRB, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, TERT, THRA, THRB, TNKS 2.62251
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.60615
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.60615
[BP] GO:0045986 None ADORA1, ADRA2C, PTGS2 2.60615
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, HMGCR, KDR, SRC 2.57676
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, NR1H4, PTGS2, TNKS, TNKS2 2.57022
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 2.54309
[BP] GO:0003018 None ADORA1, ADRA2A, ADRA2C, HMGCR, PTGS2, SRC 2.54309
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.53275
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.52758
[BP] GO:0010906 None ESRRB, GSK3B, PPARA, RORC, SRC 2.50843
[BP] GO:0060748 None AR, PGR 2.48536
[BP] GO:0046110 None AOX1, XDH 2.48536
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.48536
[BP] GO:0006808 regulation of nitrogen utilization BCL2, NR1H4 2.48536
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, CSNK2A1, DHFR, DNMT1, DYRK1A, ESR1, F3, FABP4, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.47772
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.47089
[BP] GO:0045892 None AR, AURKB, DNMT1, ESR1, ESR2, ESRRA, FABP4, MMP12, NR1H4, NR3C1, PPARA, RORC, SRC, THRA, THRB 2.45889
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.45889
[BP] GO:1901184 None ADORA1, ADRA2A, ADRA2C, APP, MMP9 2.45889
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 2.43929
[BP] GO:0010468 regulation of gene expression ADORA3, APP, AR, AURKB, BCL2, CA9, CDK6, CSNK2A1, CYP1A2, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP4, GSK3B, KDR, KIT, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TERT, THRA, THRB, TNKS, XDH 2.43281
[BP] GO:0060341 regulation of cellular localization ADRA2A, APP, AR, BCL2, CSNK2A1, GSK3B, HMGCR, NR1H4, PTGS2, PTPN1, SRC, TERT, THRA 2.43281
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DYRK1A, GSK3B, SRC, TNKS 2.42339
[BP] GO:0010556 regulation of macromolecule biosynthetic process ADORA3, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DHFR, DNMT1, ESR1, ESR2, ESRRA, ESRRB, FABP4, GSK3B, IGF1R, KDR, KIT, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2 2.42053
[BP] GO:0050994 None ADORA1, ADRA2A, PPARA, THRA 2.41731
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.41678
[BP] GO:0007617 None APP, THRA, THRB 2.41678
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DNMT1, GSK3B, IGF1R, MMP2, NR1H4, PTGS2, SRC 2.41124
[BP] GO:0009058 None ACHE, AKR1B1, ALOX5, AR, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, ESR1, ESR2, ESRRA, ESRRB, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, NR1H4, NR3C1, NR3C2, PGR, PPARA, PTGS2, RORC, TERT, THRA, THRB, TYR 2.39573
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, GSK3B, KDR, SRC 2.39573
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.39209
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, HMGCR, HSD11B2, PTGS2, SRC, TYR 2.38521
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, HMGCR, IGF1R, KIT, PTPN1, SRC 2.33652
[BP] GO:0044283 None AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP3A4, DHFR, HMGCR, IDO1, PTGS2 2.33547
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.32547
[BP] GO:0051223 None ACHE, ADRA2A, ADRA2C, APP, GSK3B, HMGCR, MMP12, NR1H4, PTGS2, PTPN1, SRC, THRA 2.32547
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.31674
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS2, SRC 2.31606
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.31117
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.31117
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.31116
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, PTGS2, TERT 2.30903
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, ESR1, FABP4, IDO1, MMP12, MMP2, NR1H4, PPARA, PTGS2, PTPN1, SRC 2.30767
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.30503
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.30503
[BP] GO:1903507 None AR, AURKB, DNMT1, ESR1, ESR2, ESRRA, FABP4, MMP12, NR1H4, NR3C1, PPARA, RORC, SRC, THRA, THRB 2.30283
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, ADRA2C, APP, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KIT, PTPN1, SRC 2.30198
[BP] GO:1902679 None AR, AURKB, DNMT1, ESR1, ESR2, ESRRA, FABP4, MMP12, NR1H4, NR3C1, PPARA, RORC, SRC, THRA, THRB 2.29702
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, NR3C1, SRC 2.27897
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DHFR, PPARA 2.26673
[BP] GO:2000112 regulation of cellular macromolecule biosynthetic process ADORA3, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DHFR, DNMT1, ESR1, ESR2, ESRRA, ESRRB, FABP4, GSK3B, IGF1R, KIT, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2 2.25682
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.256
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.256
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, MMP9, RORC 2.256
[BP] GO:2000113 None AR, AURKB, DHFR, DNMT1, ESR1, ESR2, ESRRA, FABP4, GSK3B, MMP12, NR1H4, NR3C1, PPARA, RORC, SRC, THRA, THRB 2.256
[BP] GO:0031327 None ADRA2A, AR, AURKB, DHFR, DNMT1, ESR1, ESR2, ESRRA, FABP4, GSK3B, MMP12, NR1H4, NR3C1, PPARA, RORC, SRC, THRA, THRB 2.256
[BP] GO:0035625 None ADRA2A, ADRA2C 2.256
[BP] GO:0032811 None ADRA2A, ADRA2C 2.256
[BP] GO:0070213 None TNKS, TNKS2 2.256
[BP] GO:0006145 None AOX1, XDH 2.256
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.256
[BP] GO:0001503 ossification ALPL, BCL2, MMP2, MMP9, THRA 2.23353
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.23353
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, HSD11B2, IDO1, KIT, MMP2, MMP9, NR1H4, PPARA, PTGS2, PTPN1, SRC, TERT, THRA 2.233
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.22812
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DYRK1A, GSK3B, SRC, TNKS 2.22369
[BP] GO:0051953 None ADORA1, ADRA2A, ADRA2C 2.21643
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.21643
[BP] GO:0009890 None ADRA2A, AR, AURKB, DHFR, DNMT1, ESR1, ESR2, ESRRA, FABP4, GSK3B, MMP12, NR1H4, NR3C1, PPARA, RORC, SRC, THRA, THRB 2.2
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP2, MMP9, NR1H4, PTPN1, SRC, TNKS, TNKS2 2.18495
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.178
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.1641
[BP] GO:0046888 None ADORA1, ADRA2A, ADRA2C, HMGCR 2.15622
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, FABP3, FABP4, GBA2, GSK3B, IDO1, SRC, XDH 2.14108
[BP] GO:0006066 None AKR1B1, AKR1B10, APP, CYP1B1, CYP3A4, DHFR, HMGCR 2.13433
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.13277
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.13118
[BP] GO:0006766 vitamin metabolic process AOX1, CBR1, CYP1A1, CYP3A4, DHFR 2.13118
[BP] GO:0010675 None ESRRB, GSK3B, PPARA, RORC, SRC 2.13118
[BP] GO:0045932 None ADORA1, ADRA2C, PTGS2 2.12093
[BP] GO:0045595 regulation of cell differentiation ADRA2C, APP, AR, AXL, BCL2, CA2, CDK6, ESRRA, ESRRB, GSK3B, KDR, KIT, PPARA, PTGS2, RORC, TERT, THRA, XDH 2.11839
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.11399
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, HMGCR, HSD11B2, IDO1, KIT, MMP12, NR1H4, PTGS2, SRC, TYR 2.09791
[BP] GO:0097746 None ADORA1, ADRA2A, ADRA2C, HMGCR, PTGS2 2.09156
[BP] GO:0035296 None ADORA1, ADRA2A, ADRA2C, HMGCR, PTGS2 2.09156
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, ESR1, MET, SRC 2.09156
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, GSK3B, IDO1, MMP12, NR1H4, PTGS2, SRC 2.08875
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.08406
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.08406
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.08406
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, NR1H4, PTPN1, SRC 2.08406
[BP] GO:0043696 None CDK6, ESRRB 2.08406
[BP] GO:0043697 None CDK6, ESRRB 2.08406
[BP] GO:0035624 None ADRA2A, ADRA2C 2.08406
[BP] GO:0010641 None F3, SRC 2.08406
[BP] GO:0060509 None THRA, THRB 2.08406
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.08406
[BP] GO:0014060 None ADRA2A, ADRA2C 2.08406
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, BCL2, GSK3B, MMP9, PTGS2, PTPN1, SRC, TERT 2.08406
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, HMGCR, KIT, PTGS2, TYR 2.08164
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, ADRA2C, PTGS2, THRA, THRB 2.08164
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, ADRA2C, APP, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KIT, PTPN1, SRC 2.07847
[BP] GO:0044249 None ACHE, AKR1B1, ALOX5, AR, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, ESR1, ESR2, ESRRA, ESRRB, HMGCR, HSD17B1, HSD17B2, IDO1, NR1H4, NR3C1, NR3C2, PGR, PPARA, PTGS2, RORC, TERT, THRA, THRB, TYR 2.07585
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, ESR1, F3, FLT3, FUT7, GSK3B, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2 2.07006
[BP] GO:0010558 None AR, AURKB, DHFR, DNMT1, ESR1, ESR2, ESRRA, FABP4, GSK3B, MMP12, NR1H4, NR3C1, PPARA, RORC, SRC, THRA, THRB 2.06475
[BP] GO:1900078 None ESRRA, NR1H4, SRC 2.05454
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.05454
[BP] GO:1904646 cellular response to amyloid-beta APP, GSK3B, IGF1R 2.05454
[BP] GO:1903827 regulation of cellular protein localization APP, AR, BCL2, CSNK2A1, GSK3B, PTGS2, PTPN1, SRC, TERT, THRA 2.05273
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, GSK3B, HMGCR, IDO1, MMP9, PTGS2, SRC, XDH 2.05273
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, ESR1, FABP4, IDO1, NR1H4, PPARA, PTGS2 2.04303
[BP] GO:0003013 None ADORA1, ADRA2A, ADRA2C, HMGCR, PTGS2, SRC 2.02485
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, GSK3B, HMGCR, IDO1, MMP9, PTGS2, SRC, XDH 2.02124
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.01535
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.01438
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DNMT1, GSK3B, KDR, MET, MMP9, SRC, TNKS, TNKS2 2.01383
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, CSNK2A1, DHFR, DNMT1, DYRK1A, ESR1, F3, FABP4, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.01383
[BP] GO:0050880 None ADORA1, ADRA2A, ADRA2C, HMGCR, PTGS2 2.00277
[BP] GO:0051252 regulation of RNA metabolic process ADORA3, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP4, KIT, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TERT, THRA, THRB, TNKS 2.00062
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.00034
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, ADRA2C, AKR1B1, AKR1B10, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TYR, XDH 3.58346
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA2C, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, KDR, KIT, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, SRC, TERT, THRA, TNKS, TNKS2, TYR, XDH 2.97593
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, NR3C2, PTGS2, PTPN1 2.9169
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, ADRA2C, AKR1B1, AKR1B10, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA9, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HMGCR, IDO1, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TYR, XDH 2.84503
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX5, ALPL, APP, AR, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, ESR1, F3, FLT3, FUT7, GBA2, GSK3B, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MET, MMP2, NR3C2, PGR, PIM1, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TYR 2.52764
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, APP, AR, AURKB, BACE1, BCL2, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GSK3B, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, NR3C1, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TYR, XDH 2.50903
[CC] GO:0005654 None AKR1B1, ALOX5, AR, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, GSK3B, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TERT, THRA, THRB, TNKS 2.42165
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, NR3C2, PTGS2 2.29527
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, THRA, THRB, TNKS, TYR, XDH 20.7103
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 14.9189
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TYR, XDH 14.7841
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR1H4, NR3C1, NR3C2, PGR, RORC 13.0216
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, PGR, PPARA, RORC, THRA, THRB 12.712
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, PGR, PPARA, RORC, THRA, THRB 12.712
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, THRA, THRB, TNKS 12.712
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DYRK1A, F3, FLT3, FUT7, GBA2, GSK3B, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 11.795
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.0991
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 9.17304
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, TERT, THRA, THRB, TNKS, TNKS2, TYR, XDH 8.84968
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, TERT, THRA, THRB, TNKS, TNKS2, TYR, XDH 8.54044
[MF] GO:0008289 lipid binding AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC 7.12398
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 7.10759
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 6.70306
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, HMGCR, HSD11B2, HSD17B1, IDO1, PTGS2, SRC, XDH 6.53613
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, CDK6, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 6.1499
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.14946
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 5.75555
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, ADRA2A, ADRA2C, AOX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HMGCR, HSD11B2, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, XDH 5.48589
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.27484
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.18583
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.16594
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 5.03247
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, PTGS2, SRC 4.98359
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NR3C1, THRA, THRB 4.96099
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.92346
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, AOX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HMGCR, HSD11B2, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, XDH 4.86417
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, PTGS2, SRC 4.78134
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.48993
[MF] GO:0019899 enzyme binding ADRA2A, APP, AR, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP3A4, ESR1, ESR2, ESRRB, F3, GSK3B, HMGCR, KIT, MET, NR3C1, PGR, PPARA, PTGS2, PTPN1, SRC, THRB, TNKS2 4.35922
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 4.34197
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, ADRA2C, AOX1, APP, BCL2, CSNK2A1, DYRK1A, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PGR, PTGS2, TERT, TYR, XDH 4.26314
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 3.9992
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.95482
[MF] GO:0043565 None AR, BCL2, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, TERT, THRA, THRB 3.93457
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, PPARA, SRC 3.89532
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.87826
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DAO, DHFR, DNMT1, DYRK1A, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, NR1H4, PIM1, SRC, XDH 3.60211
[MF] GO:0004887 None NR1H4, THRA, THRB 3.59684
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 3.59373
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.56533
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS2, TYR 3.45822
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.36923
[MF] GO:0008134 transcription factor binding AR, BCL2, ESR1, ESRRB, FLT3, GSK3B, NR1H4, PIM1, PPARA, SRC, TERT, THRA 3.33515
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.28789
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.28104
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.26455
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC, THRA 3.05338
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.03564
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.88346
[MF] GO:0003845 None HSD11B1, HSD11B2 2.88346
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 2.88105
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC, THRA 2.83675
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DAO, DHFR, DNMT1, DYRK1A, FLT3, GSK3B, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 2.74354
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DAO, DHFR, DNMT1, DYRK1A, FLT3, GSK3B, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 2.74181
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.65407
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA2A, ADRA2C, AOX1, AR, AXL, BCL2, DAO, FLT3, HMGCR, KIT, PTGS2, TERT, TYR, XDH 2.53905
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 2.53905
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.48536
[MF] GO:0004938 None ADRA2A, ADRA2C 2.48536
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TERT 2.43839
[MF] GO:0000981 None AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PGR, PPARA, RORC, THRA, THRB 2.42339
[MF] GO:0043168 anion binding ABCB1, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, DAO, DHFR, DYRK1A, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, KIT, MET, NR1H4, PIM1, SRC, XDH 2.42053
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.35495
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, ADRA2C, AOX1, BCL2, FLT3, HMGCR, KIT, PTGS2, TERT, TYR, XDH 2.28473
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.256
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.256
[MF] GO:0032795 None ADORA1, ADRA2A 2.256
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.256
[MF] GO:0050662 coenzyme binding AOX1, DAO, DHFR, HMGCR, HSD11B2, HSD17B1, XDH 2.16044
[MF] GO:0001077 None AR, ESR1, ESRRA, NR1H4, NR3C1, PGR, PPARA 2.16044
[MF] GO:0000976 None AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PGR, PPARA, RORC, THRA 2.12093
[MF] GO:0044212 None AR, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, THRA 2.09791
[MF] GO:0001067 None AR, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, THRA 2.09416
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.08406
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.08406
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.08406
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.05454
[MF] GO:0051721 None BCL2, HMGCR, PTPN1 2.01438
[MF] GO:0000978 None AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RORC 2.00548


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.0116
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.9974
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.488
Metabolic pathways_Homo sapiens_hsa01100 CBR1, DNMT1, AKR1B1, HMGCR, PTGS2, TYR, CYP3A4, GBA2, CYP19A1, DHFR, HSD11B1, FUT7, DAO, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1 8.0615
Pathways in cancer_Homo sapiens_hsa05200 AR, GSK3B, CDK6, FLT3, MMP1, MMP2, KIT, BCL2, PTGS2, MMP9, MET, IGF1R 5.909
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 5.9851
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, CDK6, ABCB1, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 5.2486
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.0887
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 5.0768
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.7062
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.8207
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, NR1H4, HMGCR, CYP3A4 3.8677
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.3114
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.6247
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 THRB, THRA, ADORA3, ADORA1, NR3C1, ADRA2C, ADRA2A 2.9751
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, THRB, THRA, SRC, ESR1 2.978
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, BCL2, MET, IGF1R 2.9169
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, CDK6, KIT, KDR, BCL2, MET, IGF1R 2.5627
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 2.9473
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC, ESR1, ESR2 2.8665
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.3633
Prostate cancer_Homo sapiens_hsa05215 AR, GSK3B, BCL2, IGF1R 2.5525
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9169
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, MET, IGF1R 2.0944
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 1.9115
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.0944
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 1.8099
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.0944
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.0256
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA2C, ADRA2A 1.7525
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 1.9378
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, PTGS2 2.02
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.9062
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4 1.9151
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.6605
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, PTGS2 1.7199
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, CDC25B, IGF1R 1.6162
Melanogenesis_Homo sapiens_hsa04916 GSK3B, KIT, TYR 1.6117
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.6582
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 1.4397
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, PPARA 1.5373
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, PTGS2 1.5143
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.4385
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.4506
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.265
Measles_Homo sapiens_hsa05162 GSK3B, CDK6, CSNK2A1 1.3464
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, ESRRB, IGF1R 1.3047
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDK6, CDC25B 1.4372
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.2155
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, GSK3B, APP 1.1659
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, BCL2 0.9931
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.8435
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.8425
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.8814
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9706
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC 0.9931
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, BCL2 0.8066
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.8136
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8136
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA 0.7547
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.7932
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 0.9901
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B 0.7409
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1 0.7349
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.7809
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7409
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0592
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1952
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PPARA 0.7058
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.6819
Peroxisome_Homo sapiens_hsa04146 DAO, XDH 1.0169
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6096
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2387
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.1843
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.5952
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2775
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2895
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2959
Influenza A_Homo sapiens_hsa05164 GSK3B 0.2895
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.5704
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.5844
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.3239
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3315
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3433
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.3372
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1617
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, BCL2 1.2155
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, TERT 0.488
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.3571
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.234
Platelet activation_Homo sapiens_hsa04611 SRC 0.3799
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B 0.3642
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.439
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.4318
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4433
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.439
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4479
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4484
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4475
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4568
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4575
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4589
Gap junction_Homo sapiens_hsa04540 SRC 0.4589
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4582
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5107
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.5107
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4883
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5107
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5091
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5157
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, NR3C2 1.5036
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5176
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5308
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5308
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5308
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5308
Shigellosis_Homo sapiens_hsa05131 SRC 0.5308
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5445
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5308
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.4076
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6492
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5674
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.6582
Endometrial cancer_Homo sapiens_hsa05213 GSK3B 0.5844
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.5583
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.5704
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5844
Malaria_Homo sapiens_hsa05144 MET 0.5875
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO 0.5875
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5952
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.5875
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5911
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6146
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5439
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5952
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6038
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.5993
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8099
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO 0.6328
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.6819
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7174
Folate biosynthesis_Homo sapiens_hsa00790 DHFR, ALPL 2.0944
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7349
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7547
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7258
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7442
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.8202
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8027
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8468
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9169
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2286


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)