TCM Prescription: Qu Feng Ointment



Prescription Description
Prescription IDTCMF5117
Pinyin NameQu Feng Gao
Chinese Name祛风膏
English NameQu Feng Ointment
Function Description痹病, 腹痛, 胃脘痛, 腹泻, 痢疾
IndicationsStomach ache disorder, Dysentery disorder, Abdominal pain disorder, Arthritis, Diarrhea, Dysentery
Disease ICD-11 Category SA51 [Stomach ache disorder (TM1), 胃脘痛 (TM1) ];
SA56 [Dysentery disorder (TM1), 痢疾 (TM1) ];
SA58 [Abdominal pain disorder (TM1), 腹痛 (TM1) ];
FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
ME05.1 [Diarrhoea, 腹泻 ];
1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ];
Human Tissues Associated with IndicationIntestine, Stomach, SkeletalMuscle
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH672 Alpinia officinarum 高良姜 TCMH672 ITSAK2176-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1661 Rhizoma homalomenae occultae 千年健 TCMH1661
TCMH222 Aconitum carmichaelii 草乌 TCMH222 ITSAH2410-14
TCMH2166 Clematis chinensis 威灵仙 TCMH2166
TCMH447 Illicium difengpi 地枫皮 TCMH447 AF163728
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH2044 Caesalpinia sappan 苏木 TCMH2044 ITSAJ4578-14
TCMH2176 Scolopendra subspinipes mutilans 蜈蚣 TCMH2176
TCMH2073 Prunus persica 桃仁 TCMH2073 ITSAN1047-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH354 Hydnocarpus anthelminticus 大风子 TCMH354
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH1903 Zingiber officinale 生姜 TCMH1903 ITSAO3969-14
TCMH333 Bulbus allii fistulosi 葱 TCMH333
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH486 Syzygium aromaticum 丁香 TCMH486 GBVI185-11
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH1508 Commiphora myrrha 没药 TCMH1508 MH522406
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT678 XIAP Inhibitor of apoptosis protein 3 Transferase P98170
TCMT679 MPEG1 Macrophage-expressed gene 1 protein Unclassified Q2M385
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT714 ODC1 Ornithine decarboxylase Lyase P11926
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1188 Leishmania braziliensis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRB1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1B1, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MAOA, MET, MIF, MTNR1B, POLA1, POLB, PPARA, SLC1A1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 12.9941
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.5132
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, NR3C1, POLB, PPARA, PTGES, RORC, SMAD3, SRC, TEK, TRPV1, TYR 10.2157
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, GRIK5, GRM5, HSD17B2, IGF1R, INSR, MMP2, MMP9, NR3C1, POLB, PPARA, PTGES, RORC, SRC, TEK, TRPV1, TYR 10.2157
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, MIF, PPARA, PTGES, TBXAS1, TRPV1 10.0896
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGES, TBXAS1 10.0658
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.81495
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, TBXAS1 9.81495
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGES, TBXAS1 9.7978
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, FLT3, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, MET, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 9.13316
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, FLT3, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, MET, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 9.10684
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, POLB, PPARA, PTGES, RORC, SMAD3, SRC, TEK, TERT, TRPV1, TYR 9.02233
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GLO1, HSPA1A, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR, XDH 8.73206
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 8.62461
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.60093
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, APP, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, EGFR, ERBB2, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NUAK1, PGR, PIM1, PTGES, SMAD3, SRC, TEK, TERT, XDH 8.60093
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 8.58323
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CYP1B1, EGFR, ERBB2, F10, F3, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MIF, PTPN1, SRC, TEK, XDH 8.44517
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK, TERT 8.42655
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, AKR1B1, ALOX12, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, MET, MTNR1B, POLA1, POLB, SMAD3, SRC, TERT, TRPV1 8.41186
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NR3C1, NUAK1, POLA1, POLB, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 8.40426
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APEX1, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, MTNR1B, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1 8.40426
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK, TERT 8.36496
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, RORC, SMAD3, SRC, TERT, TRPV1 8.30318
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 8.18243
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGES, TBXAS1 8.13086
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ERBB2, F10, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, MMP9, MTNR1A, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 7.92085
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK, TERT 7.76595
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ERBB2, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, NR3C1, PPARA, SMAD3, SRC, TEK, TRPV1 7.7536
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.7536
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, MTNR1B, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.63404
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, TBXAS1 7.61111
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, F10, F3, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.51577
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, MTNR1B, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.48275
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGES, SRC, TERT 7.47828
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ERBB2, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, NR3C1, RORC, SMAD3, SRC, TRPV1 7.45968
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK, TERT 7.37351
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MIF, MMP1, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TRPV1, TYR, XDH 7.3447
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT 7.33065
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 7.28264
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, PTGES, TBXAS1 7.20667
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, F10, F3, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 7.07794
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, NR3C1, PTGES, RORC, SRC, TEK, TRPV1, TYR 7.05438
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRB1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, MMP9, MTNR1A, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 6.98632
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MIF, MMP9, MTNR1A, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.90859
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MIF, MMP9, MTNR1A, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.83122
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 6.66132
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FUT7, MET, MIF, PPARA, PTGES, TBXAS1 6.51613
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 6.32799
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, NR3C1, PTGES, RORC, SRC, TYR 6.32799
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NR3C1, NUAK1, POLA1, POLB, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR 6.28709
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, ERBB2, FABP3, FLT3, GRM1, GRM5, INSR, KDR, MIF, MMP9, MTNR1A, PTPN1, SMAD3, SRC, TEK, XDH 6.21582
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, ERBB2, FABP3, FLT3, GRM1, GRM5, INSR, KDR, MIF, MMP9, MTNR1A, PTPN1, SMAD3, SRC, TEK, XDH 6.21582
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MIF, MMP1, MMP2, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TYR, XDH 6.21165
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, NR3C1, PPARA, SRC, TEK, TRPV1 6.14742
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.09152
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 6.02422
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CDK6, CSNK2A1, CYP1B1, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, MTNR1A, MTNR1B, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLB, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 5.85394
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.8267
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, AR, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ERBB2, F3, FLT3, IGF1R, INSR, KDR, MIF, MMP2, MMP9, PIM1, TEK, TERT 5.70197
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.67919
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, FLT3, HSD11B1, HSD17B2, INSR, KDR, POLB, PPARA, SMAD3, SRC, TEK, TYR 5.66472
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, MIF, PPARA, PTGES, TBXAS1 5.59147
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, INSR, KDR, MET, MIF, MMP2, MMP9, PGR, PIM1, POLB, PPARA, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR 5.51266
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.49354
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 5.45912
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TRPV1 5.43329
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, F10, F3, FABP4, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MIF, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.37676
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CDK6, CYP1B1, EGFR, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, NR3C1, RORC, SRC, TRPV1 5.32717
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, MTNR1B, SMAD3, TRPV1 5.2895
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.27007
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, AR, EGFR, ERBB2, FLT3, GRM1, INSR, KDR, MIF, PTPN1, SRC, TEK, XDH 5.27007
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.20863
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD11B1, HSD17B1, HSD17B2 5.15085
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.9995
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, F10, F3, INSR, MET, SRC, TEK 4.93961
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, AR, DUSP3, EGFR, ERBB2, FLT3, GRM1, IGF1R, INSR, KDR, MIF, PTPN1, SRC, TEK, XDH 4.90154
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, GRM1, HSPA1A, MMP2, POLB, PPARA, SMAD3, SRC, TEK, TERT, TRPV1, TYR 4.8998
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.8863
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, ERBB2, F10, F3, INSR, MET, SRC, TEK, XDH 4.80693
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, F3, FABP4, GRM1, GRM5, GRM8, HSD17B2, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TRPV1, TYR 4.76847
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 4.62694
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, MTNR1A, MTNR1B, PGR, PPARA, RORC, SRC, TOP2A 4.60286
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, AR, CYP1A1, CYP1B1, EGFR, FLT3, NR3C1, RORC, SRC, TRPV1 4.60286
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRB1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, MTNR1A, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 4.60286
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CYP19A1, EGFR, ERBB2, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, INSR, MIF, MMP9, MTNR1B, PPARA, PTPN1, SMAD3, SRC, TERT, TRPV1 4.59951
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MIF, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, RORC, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TRPV1, TYR, XDH 4.48504
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, ERBB2, PPARA, SMAD3 4.40391
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRB1, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ERBB2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.38521
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 4.38188
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 4.38188
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 4.3726
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 4.19661
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SRC, TEK, XDH 4.16594
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8 4.16594
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGES, TERT 4.15435
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRB1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, EGFR, ERBB2, F3, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, MTNR1A, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 4.14931
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.14414
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, CDK6, EGFR, HCAR2, KDR, MIF, SRC, TRPV1 4.09494
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.09364
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.07493
[BP] GO:0042391 None ADORA1, APP, BCL2, CACNA1C, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 4.06815
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 4.04502
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, EGFR, ERBB2, FLT3, MET, MIF, PIM1, POLA1, SRC, TEK, TYR 4.03864
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, MIF, MMP9, PPARA, PTPN1, SRC, TEK, XDH 4.01977
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TOP2A 4.00616
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, NR3C1, PGR, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.94254
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR 3.94254
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, ERBB2, FLT3, GRM1, IGF1R, INSR, MIF, PTPN1, SRC 3.92767
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 3.89413
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, ERBB2, KDR, MIF, PTPN1, SRC, TEK 3.89413
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, ALOX12, APP, AR, AXL, BCL2, CA2, CYP1B1, EGFR, F3, HCAR2, HSPA1A, KDR, MET, MIF, MMP9, PIM1, SLC1A1, SMAD3, SRC, TEK, TERT, TRPV1 3.89413
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, MIF, PTGES 3.87145
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.86572
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SRC, TEK, XDH 3.8513
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, AR, EGFR, ERBB2, FLT3, GRM5, IGF1R, INSR, MMP2, NR3C1, SMAD3, SRC, TRPV1 3.84645
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GRM5, IGF1R, INSR, PPARA, SRC, TEK, TRPV1 3.84493
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, HCAR2, HSD11B1, HSD17B1, HSD17B2, MTNR1B 3.826
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, KDR, NR3C1, SRC, TRPV1 3.80465
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, F3, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, MTNR1A, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.79508
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.729
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRB1, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MET, MIF, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 3.69228
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, POLB, PPARA, SMAD3, SRC, TEK, TERT 3.69228
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, APP, CDK6, CYP19A1, DUSP3, EGFR, F3, FABP4, HSPA1A, IGF1R, MET, MIF, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.69204
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, MIF, SRC, TERT 3.61077
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, HSPA1A, MIF, MMP2, MMP9, NUAK1, POLA1, POLB, PPARA, PTGES, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1 3.60462
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PGR, PIM1, POLB, PPARA, RORC, SMAD3, SRC, TEK, TYR 3.5926
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, AR, BCL2, CDK6, CYP19A1, DUSP3, EGFR, ERBB2, HSPA1A, IGF1R, MET, MIF, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.58835
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 3.58773
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TRPV1, TYR, XDH 3.5758
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.57263
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.55846
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRB1, APP, AR, AURKB, BCL2, CDC25B, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, MET, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.5576
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.55608
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, KDR, NR3C1, POLB, SRC, TRPV1 3.50035
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRB1, ALOX12, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CYP1B1, EGFR, ERBB2, F3, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, MET, MIF, MMP9, PIM1, SLC1A1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 3.45743
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 3.45743
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR 3.44454
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, ERBB2, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 3.43695
[BP] GO:0007187 None ADORA1, ADRB1, GRM1, GRM3, GRM5, GRM8, MTNR1A, MTNR1B 3.43377
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.42628
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, MIF, PTPN1, SRC, TEK 3.42628
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.41782
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 3.41501
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD11B1, HSD17B1, HSD17B2 3.41501
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, MIF, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.37016
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR 3.36705
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.36705
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.36705
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR 3.36705
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, NR3C1, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.36705
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GRIK5, INSR, MAOA, SLC1A1, SMAD3, TRPV1 3.33406
[BP] GO:0007154 None ADORA1, ADRB1, AR, AXL, BCL2, CACNA1C, GRIA2, GRIK5, GRM1, GRM3, GRM5, MTNR1B, PGR, SLC1A1, TEK, TRPV1 3.32899
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.29903
[BP] GO:0050678 None AR, CDK6, EGFR, ERBB2, F3, KDR, PGR, SMAD3, TEK, XDH 3.29796
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.29321
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK, TERT 3.29281
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 3.28655
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.26524
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, MAOA, TYR 3.2517
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, INSR, MIF, PTPN1, SRC 3.23524
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, F10, F3, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.21466
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, MIF, PTPN1, SRC 3.20781
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MIF, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TRPV1, TYR, XDH 3.20781
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK, TERT 3.20781
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, TERT 3.18128
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.18128
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC 3.16153
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.14986
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.14653
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, MIF, PTPN1, SRC, TEK 3.14004
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCL2, CDK6, CYP1B1, ERBB2, FABP3, HSPA1A, PTGES, SMAD3, TERT, XDH 3.13352
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, KDR, SRC, TRPV1 3.11149
[BP] GO:0070848 response to growth factor APP, EGFR, ERBB2, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 3.07183
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC, TERT 3.06991
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRB1, AKR1B1, ALOX12, ALOX15, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, F10, F3, FABP4, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.03361
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR 3.02931
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.02197
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRB1, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, MTNR1A, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.0141
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 3.0064
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRB1, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, MTNR1A, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 2.98577
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, SMAD3, SRC, TEK 2.98577
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, MIF, PTGES 2.97517
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, EGFR, FLT3, NR3C1, SRC 2.96918
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 2.96578
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, SMAD3, SRC, TERT, TOP2A 2.96578
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 2.95604
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 2.94125
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 2.92972
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.92972
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, INSR, MIF, PTPN1, SRC, TEK 2.90547
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, ALPL, APP, AR, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, EGFR, ERBB2, FABP4, FLT3, FUT7, GLO1, KDR, MET, MIF, MMP2, MMP9, PGR, RORC, SMAD3, SRC, TEK, TERT, TOP2A 2.90547
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 2.89126
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 2.89126
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD17B1, HSD17B2, MIF, PTGES 2.87331
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, EGFR, ERBB2, HCAR2, INSR, MIF, SMAD3, SRC, TERT, TRPV1 2.86079
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, GRM5, MIF, PTPN1, SRC 2.83013
[BP] GO:0009755 hormone-mediated signaling pathway AR, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 2.82464
[BP] GO:0019371 None CBR1, PTGES, TBXAS1 2.81226
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, TRPV1, XDH 2.79464
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, NQO2, RORC 2.77285
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, FABP3, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.74354
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, BCL2, CDK6, CYP1B1, DUSP3, ERBB2, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.74354
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, ERBB2, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 2.74204
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 2.74204
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, GRM5, IGF1R, INSR, MMP2, SRC, TRPV1 2.72862
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MIF, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 2.72186
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.72186
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.72186
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.72186
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.72186
[BP] GO:0030522 intracellular receptor signaling pathway AR, NR3C1, PGR, PIM1, PPARA, RORC, SRC 2.72186
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.71667
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB1, AKR1B1, ALOX12, MET, TRPV1 2.71419
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, KDR, POLB, SRC 2.68307
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1, SRC 2.68241
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, INSR, MIF, PTPN1, SRC, TEK 2.66607
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRB1, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, MTNR1A, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 2.64136
[BP] GO:0071383 None AR, EGFR, FLT3, NR3C1, SRC 2.62631
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.62048
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, ERBB2, FLT3, GRM1, IGF1R, INSR, MIF, PTPN1, SRC 2.5949
[BP] GO:0023052 None ADORA1, ADRB1, AR, CACNA1C, GRIA2, GRIK5, GRM1, GRM3, GRM5, MTNR1B, PGR, SLC1A1, TEK 2.59401
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 2.58088
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 2.58088
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRB1, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, MTNR1A, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 2.56615
[BP] GO:0042060 None ALOX15, EGFR, ERBB2, PPARA, SMAD3 2.55791
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, SMAD3, SRC, TEK 2.55519
[BP] GO:0033554 cellular response to stress AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, MIF, MMP9, NUAK1, POLA1, POLB, PTPN1, SRC, TERT, TOP2A, TRPV1 2.54273
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, INSR, MIF, PTPN1, SRC 2.52466
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, BCL2, DUSP3, EGFR, ERBB2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP9, PTPN1, SMAD3, SRC, TERT, XDH 2.50748
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, BCL2, DUSP3, EGFR, ERBB2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP9, PTPN1, SMAD3, SRC, TERT, XDH 2.49251
[BP] GO:0044057 None ADORA1, ADORA3, ADRB1, CACNA1C, EGFR, GPR35, GRM1, HCAR2, SLC1A1, SMAD3, TRPV1 2.49251
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, MIF, PTGES 2.49087
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, EGFR, GRM5, IGF1R, INSR, MMP2, SRC, TRPV1 2.49087
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC, TERT 2.48787
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR, MIF, TERT 2.48699
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, SMAD3, TRPV1 2.47699
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.47699
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, SRC 2.47367
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, MIF 2.44947
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, KDR, MIF, SRC, TEK 2.44947
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1, TRPV1 2.44323
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR, HSPA1A, MAOA 2.4424
[BP] GO:0007267 None ADORA1, ADRB1, AR, GRIA2, GRIK5, GRM1, GRM3, GRM5, MTNR1B, PGR, SLC1A1, TEK 2.44039
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, INSR, MIF, PTPN1, SRC 2.42898
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.41037
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.40984
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.38441
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.34248
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.33538
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, RORC, SRC, TEK 2.33205
[BP] GO:0099566 None GRM1, GRM5 2.33205
[BP] GO:0060748 None AR, PGR 2.33205
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.33205
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.33205
[BP] GO:0002520 None CACNA1C, SMAD3 2.33205
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.33205
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GRM5, IGF1R, INSR, SRC 2.33205
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DUSP3, EGFR, HSPA1A, IGF1R, MET, MIF, NUAK1, PTPN1, TERT, XDH 2.31648
[BP] GO:0090342 None CDK6, MIF, NUAK1, TERT 2.31625
[BP] GO:0040008 regulation of growth ADRB1, ALOX12, APP, AR, BCL2, CSNK2A1, EGFR, ERBB2, HSPA1A, INSR, PIM1, SMAD3 2.29385
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, TRPV1, XDH 2.29385
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.25683
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, HSD17B2, INSR, MMP2, MMP9, MTNR1A, PGR, SRC, TOP2A 2.25683
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 2.2042
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MIF, MMP9, PTPN1, SMAD3, SRC, TERT 2.19774
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.19164
[BP] GO:0045766 positive regulation of angiogenesis ALOX12, CYP1B1, F3, KDR, TEK, TERT 2.17531
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, NR3C1, SRC 2.1611
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, CACNA1C, GPR35, GRIK5, GRM1, GRM5, POLA1, SMAD3, TRPV1 2.15638
[BP] GO:0007188 None ADORA1, ADRB1, GRM1, GRM3, GRM5, GRM8 2.14875
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.1328
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AR, AURKB, BCL2, CSNK2A1, DUSP3, EGFR, FABP4, GRM3, GRM8, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 2.12655
[BP] GO:1901184 None ADORA1, APP, EGFR, ERBB2, MMP9 2.12649
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC 2.12649
[BP] GO:0035556 intracellular signal transduction ADRB1, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, EGFR, ERBB2, GRM5, IGF1R, INSR, KDR, MET, MIF, NUAK1, POLB, PTPN1, SRC, TEK 2.12269
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.10934
[BP] GO:0032880 regulation of protein localization ACHE, APP, AR, BCL2, CACNA1C, CSNK2A1, EGFR, ERBB2, HCAR2, MIF, MTNR1B, PTPN1, SMAD3, SRC, TERT 2.1053
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, NR3C1, NR3C2, PGR, PPARA, RORC 2.1014
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.09615
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.09615
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.09615
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.09615
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, APP, AR, AURKB, EGFR, ERBB2, FABP3, IGF1R, INSR, KDR, MET, MTNR1A, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 2.0959
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, MIF, POLB, TERT 2.09549
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.08901
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.08901
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.0874
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, BCL2, HSPA1A, SRC, TERT 2.0666
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CACNA1C, EGFR, ERBB2, HCAR2, MIF, MTNR1B, PTPN1, SMAD3, SRC 2.04807
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 2.04807
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, EGFR, HSD17B2, INSR, PGR, SRC 2.03846
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.03772
[BP] GO:0090344 None CDK6, MIF, TERT 2.03689
[BP] GO:0022612 gland morphogenesis BCL2, EGFR, POLB 2.03689
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.03689
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.03484
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, POLB, TEK, TYR 2.02672
[BP] GO:0044236 multicellular organism metabolic process ADRB1, MMP1, MMP2, MMP9, TRPV1 2.02173
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, CDK6, KDR, SMAD3, TEK 2.02173
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.01908
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.01908
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGES, SRC 2.0077
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.00708
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, GRIK5, HCAR2, MMP9, SMAD3, SRC, TOP2A, TRPV1, XDH 2.00433
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRB1, ALOX12, ALOX15, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, EGFR, ERBB2, F10, F3, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TEK, TERT, TRPV1 5.6934
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRB1, ALOX15, APP, AXL, CA2, CA4, CA9, CACNA1C, DUSP3, EGFR, ERBB2, F10, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, SLC1A1, SRC, TEK, TRPV1 5.00417
[CC] GO:0043235 receptor complex APP, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, MTNR1A, NR3C2, SMAD3 4.95205
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRB1, ALOX12, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, F10, F3, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MAOA, MET, MMP2, MTNR1A, MTNR1B, NR3C2, PGR, PIM1, PTGES, PTPN1, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TERT, TRPV1, TYR 4.8906
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRB1, APP, AXL, CA4, F10, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, SLC1A1, TEK, TRPV1 4.72909
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, SLC1A1, SRC, TEK, TRPV1 4.42968
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRB1, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MAOA, MET, MPEG1, MTNR1A, MTNR1B, NR3C2, PTGES, PTPN1, SLC1A1, SRC, TBXAS1, TEK, TRPV1, TYR 3.86347
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRB1, APP, AXL, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, SLC1A1, TEK, TRPV1 3.43106
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, APP, AR, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CACNA1C, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MAOA, MIF, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, POLA1, PTGES, PTPN1, SMAD3, SRC, TBXAS1, TERT, TOP2A, TRPV1, TYR, XDH 3.36546
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.20781
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 2.93704
[CC] GO:0044456 None ACHE, ADORA1, APP, CACNA1C, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC, TRPV1 2.61025
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2, TEK 2.58031
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, F10, FLT3, GRIA2, HSD11B1, HSD17B2, NR3C2, PTGES, PTPN1, TBXAS1 2.48691
[CC] GO:0014069 None ADORA1, CACNA1C, GRIK5, GRM1, GRM3, GRM5, SRC 2.44118
[CC] GO:0099572 None ADORA1, CACNA1C, GRIK5, GRM1, GRM3, GRM5, SRC 2.44118
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 2.28584
[CC] GO:0031233 None CA4, F10, F3 2.13129
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, GRIA2, HSD11B1, HSD17B2, NR3C2, PTGES, TBXAS1 2.08312
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, GLO1, MMP1, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 16.3837
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.8363
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, RORC, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TRPV1, TYR, XDH 11.2762
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 11.1217
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, F10, F3, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MIF, MMP1, MMP2, MMP9, NQO2, NUAK1, PIM1, POLA1, POLB, PTGES, PTPN1, SRC, TBXAS1, TEK, TERT, TOP2A, TYR, XDH 10.8087
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.79167
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, AR, AXL, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, NR3C1, NR3C2, PGR, PPARA, RORC, TEK, TRPV1 9.64959
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, AR, AXL, CDK6, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, NR3C1, NR3C2, PGR, PPARA, RORC, TEK, TRPV1 8.75899
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, AR, AXL, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, NR3C1, NR3C2, PGR, PPARA, RORC, TEK, TRPV1 8.46927
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, POLB 8.41186
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRB1, AR, AXL, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, NR3C1, NR3C2, PGR, PPARA, RORC, SMAD3, TEK, TRPV1 8.2335
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, TEK 8.01189
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, GLO1, MMP1, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SLC1A1, SMAD3, TBXAS1, TERT, TOP2A, TRPV1, TYR, XDH 7.83825
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 7.7536
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, MMP1, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, SMAD3 7.75348
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.69907
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, GLO1, MMP1, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SLC1A1, SMAD3, TBXAS1, TERT, TOP2A, TRPV1, TYR, XDH 7.66004
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, TEK 7.21859
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, IGF1R, INSR, MTNR1A, NQO2, NR3C1 6.96371
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, XDH 6.9362
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK, TRPV1 6.56008
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK, TRPV1 6.56008
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.16745
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.36024
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 5.33491
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, INSR, KDR 4.8863
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.81721
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, PPARA, SRC, TEK, TOP2A, TRPV1 4.62694
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 4.4309
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 4.20404
[MF] GO:0003707 steroid hormone receptor activity AR, NR3C1, NR3C2, PGR, PPARA, RORC 4.16594
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.04393
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, NQO2, POLA1, PTGES, SRC, TBXAS1, XDH 4.03497
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 3.89413
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, SRC, TEK, TERT 3.67528
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.50047
[MF] GO:0019899 enzyme binding ADRB1, APP, AR, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, ERBB2, F3, GRM5, HSPA1A, MET, MIF, NR3C1, PGR, POLA1, POLB, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A 3.41501
[MF] GO:0005496 steroid binding AR, HSD17B1, NR3C1, NR3C2, PGR, RORC 3.36705
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2, XDH 3.31048
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, F10, F3, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, PPARA, RORC, TRPV1 3.29281
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.23468
[MF] GO:0019902 phosphatase binding BCL2, EGFR, ERBB2, MET, PPARA, PTPN1, SMAD3 2.8687
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.84969
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 2.7384
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.72186
[MF] GO:0008389 None CYP2A13, CYP2A6 2.72186
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2 2.69501
[MF] GO:0005057 signal transducer activity, downstream of receptor ADRB1, EGFR, ERBB2, INSR, KDR, SMAD3 2.64136
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, EGFR, ERBB2, FLT3, GRIK5, IGF1R, KDR, MET, MIF, MMP9, NQO2, PGR, SMAD3, TERT, TOP2A, TRPV1, TYR, XDH 2.64136
[MF] GO:0043168 anion binding ALOX15, APP, AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, PTGES, SLC1A1, SRC, TEK, TOP2A, TRPV1, XDH 2.58467
[MF] GO:0019838 growth factor binding EGFR, ERBB2, IGF1R, INSR, KDR, TEK 2.51076
[MF] GO:0008502 None MTNR1A, MTNR1B 2.33205
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.33205
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.33205
[MF] GO:0099583 None GRM1, GRM5 2.33205
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 2.26978
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.25215
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, PGR, PPARA, RORC 2.21935
[MF] GO:0004879 nuclear receptor activity AR, PGR, PPARA, RORC 2.21935
[MF] GO:0016853 None ALOX12, ALOX15, MIF, PTGES, TBXAS1, TOP2A 2.21479
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.19164
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.19164
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, POLA1, SLC1A1, SRC, TEK, TOP2A, TRPV1, XDH 2.14875
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC 2.12649
[MF] GO:0004971 None GRIA2, GRIA4 2.0874
[MF] GO:0051425 None APP, INSR 2.0874
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.03653


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 16.988
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, GPR35, GRIK5, ADRB1, TRPV1, NR3C1, GRM1, GRM3, GRM5, MTNR1A, MTNR1B, ADORA3, GRM8, ADORA1, GRIA4 9.5727
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.4697
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, ERBB2, MET, EGFR, IGF1R 8.4697
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 6.9562
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.5508
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 6.0595
Pathways in cancer_Homo sapiens_hsa05200 AR, CDK6, SMAD3, FLT3, MMP1, MMP2, ERBB2, BCL2, MMP9, MET, EGFR, IGF1R 5.2699
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, ALOX15, AKR1B1, ALOX12, TYR, CYP19A1, HSD11B1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, PTGES 5.4248
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.9666
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.6647
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1, ALOX12, PTGES 5.1922
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, ERBB2, KDR, MMP9, MET, EGFR, IGF1R 4.2043
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1, EGFR, HSPA1A 4.0889
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ERBB2, BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 3.9626
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, ERBB2, BCL2, TEK, EGFR, IGF1R 4.0177
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, ADRB1, MET, EGFR, IGF1R, HSPA1A 3.5702
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOA, ALOX5, ALOX15, ALOX12, CACNA1C 3.8601
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, ADORA1, ADRB1, CACNA1C, PPARA, GRIA4 3.4628
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, BCL2, MET, EGFR, IGF1R 3.4418
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 3.3904
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, GRM8, GRM1, EGFR 3.3904
Prostate cancer_Homo sapiens_hsa05215 AR, ERBB2, BCL2, EGFR, IGF1R 3.3904
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1, F3 3.1765
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, ADRB1, GRM1, EGFR 3.3904
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, MTNR1A, MTNR1B, CACNA1C, GRIA4 3.2716
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 2.9618
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CACNA1C, GRM1, GRIA4 3.1765
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, ERBB2, ADRB1, CACNA1C, GRM1, EGFR 2.9618
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 3.5081
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, ADRB1 3.105
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 2.5444
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, SRC, BCL2, MMP9 2.585
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 2.7481
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, ERBB2, EGFR 2.8821
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, CACNA1C, GRM1 2.8821
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOA, CACNA1C, GRIA4 2.8817
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, ERBB2, MET, EGFR 2.8817
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRB1, CACNA1C 2.3537
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 2.8085
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, CACNA1C, EGFR 2.4538
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.8447
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOA, CACNA1C, GRIA4 1.9547
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, CACNA1C, EGFR, CDC25B, HSPA1A 1.6778
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.5507
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.0002
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, ERBB2, EGFR 2.068
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 1.6315
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.9477
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 1.9454
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.5403
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, CDC25B, IGF1R 1.5403
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2, CACNA1C 1.4275
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.4359
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 1.9477
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.8979
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.3634
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.3504
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.3341
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2 1.8881
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 1.9454
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, HSPA1A 1.2494
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.1406
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.3308
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRB1, CACNA1C 1.172
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, EGFR 1.1263
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOA 2.2256
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 0.9147
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2226
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2289
Alcoholism_Homo sapiens_hsa05034 MAOA 0.2353
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2286
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.239
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, SRC 0.9126
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2752
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3, TERT 0.7201
Apoptosis_Homo sapiens_hsa04210 BCL2 0.2994
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3102
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.4619
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.734
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.5632
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.5864
Axon guidance_Homo sapiens_hsa04360 MET 0.3245
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.7307
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7515
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.6819
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.6196
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.6972
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6819
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.6749
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5594
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.34
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.6438
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.6749
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.5867
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.34
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.34
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3603
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.3735
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3806
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.373
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.3806
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3806
Taste transduction_Homo sapiens_hsa04742 CACNA1C, GRM1 0.9662
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3901
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.3893
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.9126
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9278
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4021
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 0.9278
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 0.9355
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4041
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.9126
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 0.9439
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.4041
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4124
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4041
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3 1.051
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4113
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4031
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0044
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4161
Peroxisome_Homo sapiens_hsa04146 XDH 0.4136
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4136
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4265
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 0.9996
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.443
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4281
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4394
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4467
Bile secretion_Homo sapiens_hsa04976 CA2 0.4448
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4394
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4488
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4619
Shigellosis_Homo sapiens_hsa05131 SRC 0.4619
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.167
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, MIF, TYR 2.6033
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.1593
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2053
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.1321
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.183
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.2683
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5204
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.2784
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5535
Malaria_Homo sapiens_hsa05144 MET 0.5578
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR, CACNA1C 1.3219
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR, NR3C2 1.4378
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.3391
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.4297
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6094
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6544
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6196
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6196
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5622
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.6308
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.684
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.724
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.5504
DNA replication_Homo sapiens_hsa03030 POLA1 0.6469
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4978
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7307
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6934
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8055
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.724
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.7515
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.8867
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA, MIF 2.0002
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9355


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)