TCM Prescription: Qing Gan Zhi Lin Decoction



Prescription Description
Prescription IDTCMF2878
Pinyin NameQing Gan Zhi Lin Tang
Chinese Name清肝止淋汤
English NameQing Gan Zhi Lin Decoction
Function Description妇人有带下而色红者, 似血非血, 淋沥不断, 所谓赤带也治法须清肝火而扶脾气, 则庶几可愈方用清肝止淋汤
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationUterus
ReferenceSATCM
Reference Book/linkhttp://www.satcm.gov.cn/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1896 Radix rehmanniae 生地黄 TCMH1896
TCMH541 Colla corii asini 阿胶 TCMH541
TCMH571 Paeonia suffruticosa 粉丹皮 TCMH571 ITSAP4470-14
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH885 Fructus zizyphi jujubae 红枣 TCMH885
TCMH2293 Phaseolus vulgaris 小黑豆 TCMH2293 ITSAA4763-14
Reference: SATCM

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT673 SERPINE1 Plasminogen activator inhibitor-1 Unclassified P05121
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT974 GPER1 G-protein coupled estrogen receptor 1 GPCR Q99527
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1390 Human herpesvirus 2 strain G
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 9.83629
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9 8.89022
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F10, F3, FABP3, FABP4, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD17B1, HSD17B2, KDR, MET, PPARA, SERPINE1, SLC1A1, SRC, XDH 8.65275
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 7.92666
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AR, AXL, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, GPER1, GRIK5, GRM5, HSD17B2, IGF1R, MMP2, MMP9, PPARA, SERPINE1, SRC, TYR 7.75731
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, PIM1, PPARA, TYR, XDH 6.96806
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.89891
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA 6.73334
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD1, DRD2, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8 6.59151
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD1, DRD2, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8 6.59151
[BP] GO:0010033 response to organic substance AKR1B1, AR, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM5, HSD17B2, IGF1R, KDR, MMP2, PPARA, SERPINE1, SRC, TYR 6.53178
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, HSD17B1, HSD17B2 6.35892
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8 6.16284
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, SLC1A1 6.14352
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.75185
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AR, AURKB, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F10, F3, FLT3, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP9, PTPN1, SERPINE1, SRC, XDH 5.56569
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AR, AURKB, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F10, F3, FLT3, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP9, PTPN1, SERPINE1, SRC, XDH 5.45624
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PIM1, PPARA, SRC 5.41308
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.40678
[BP] GO:0042221 response to chemical AKR1B1, AR, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM5, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, SERPINE1, SRC, TYR 5.3747
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CYP1B1, ESR1, F3, FLT3, GPER1, GRIK5, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SERPINE1, SRC, XDH 5.36988
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AR, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, FLT3, GPER1, GRM1, HCAR2, KDR, MET, MMP9, PTPN1, SRC, XDH 5.3494
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AR, AURKB, AXL, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPER1, GRIK5, GRM1, GRM5, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SERPINE1, SRC, XDH 5.33499
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AR, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, FLT3, GPER1, GRM1, HCAR2, KDR, MET, MMP9, PTPN1, SRC, XDH 5.33499
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.30142
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, ESR1, GPER1, HCAR2, HSD17B1, HSD17B2 5.29193
[BP] GO:0033993 response to lipid AR, AXL, CA2, CA9, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GPER1, HSD17B2, SERPINE1, SRC, TYR 5.29193
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, SRC 5.29193
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CYP1B1, ESR1, F3, FLT3, GPER1, GRIK5, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SERPINE1, SRC, XDH 5.29193
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.24024
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AR, AURKB, AXL, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SERPINE1, SLC1A1, SRC, XDH 5.14924
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, SLC1A1 5.02067
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, GPER1, IGF1R, KDR, MET, MMP9, SERPINE1, SRC 4.96564
[BP] GO:0007188 None ADORA1, DRD1, DRD2, GPER1, GRM1, GRM3, GRM5, GRM8 4.76188
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CYP1B1, ESR1, F3, FLT3, GPER1, GRIK5, HCAR2, IGF1R, KDR, MMP9, PIM1, PTPN1, SERPINE1, SRC, XDH 4.71105
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, GPER1, IGF1R, KDR, MET, MMP9, SERPINE1, SRC 4.64187
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, SRC 4.56461
[BP] GO:0014070 response to organic cyclic compound AR, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FLT3, GPER1, SRC, TYR 4.50686
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AR, AXL, CYP1B1, DRD2, F10, F3, FLT3, GPER1, GRM1, KDR, MET, PTPN1, SRC, XDH 4.50686
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.48202
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AR, CA2, CA9, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, GPER1, GRM5, IGF1R, MMP2, PPARA, SRC 4.48202
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, AR, CDC25B, DRD1, DRD2, ESRRB, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 4.45351
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, AR, CDC25B, DRD1, DRD2, ESRRB, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 4.39998
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, AR, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRB, F10, F3, FABP4, GPER1, GRM1, GRM5, GRM8, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TYR 4.38878
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AR, AXL, CYP1B1, DRD1, ESR1, GPER1, GRIK5, GRM5, IGF1R, MMP2, MMP9, SERPINE1, SRC 4.34756
[BP] GO:0007187 None ADORA1, DRD1, DRD2, GPER1, GRM1, GRM3, GRM5, GRM8 4.32186
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, GPER1, IGF1R, KDR, MET, MMP9, SERPINE1, SRC 4.27712
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, GPER1, IGF1R, KDR, MET, MMP9, SERPINE1, SRC 4.26719
[BP] GO:0007193 None ADORA1, DRD2, GRM1, GRM3, GRM5, GRM8 4.26719
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, HSD17B2, TYR, XDH 4.26153
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AR, CDC25B, CYP1B1, DRD2, ESR1, ESRRA, F3, FABP3, FLT3, GPER1, IGF1R, KDR, MMP2, MMP9, PIM1, SRC, XDH 4.24267
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AR, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, SERPINE1, SRC 4.19939
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, MET, SRC 4.07407
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SRC 4.06499
[BP] GO:0071310 cellular response to organic substance AKR1B1, AR, AXL, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM5, IGF1R, KDR, MMP2, SERPINE1, SRC 4.05703
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, GPER1, KDR, SRC 3.96659
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, F10, F3, GPER1, MET, SRC, XDH 3.92397
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, AR, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 3.92372
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, AR, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 3.92372
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, FABP3, FABP4, FUT7, MET, PPARA 3.92047
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AR, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, GPER1, GRIK5, GRM5, HCAR2, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SERPINE1, SRC 3.92047
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.72449
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1 3.6919
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.67154
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.61973
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AR, AURKB, AXL, CYP1B1, DRD2, ESR1, F10, F3, FLT3, GPER1, GRM1, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 3.60352
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.6028
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.6028
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.58054
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD1, DRD2 3.58054
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 3.55958
[BP] GO:0042325 regulation of phosphorylation ADORA1, AR, CDC25B, DRD1, DRD2, ESRRB, FABP4, FLT3, GPER1, GRM1, GRM5, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.54088
[BP] GO:0009725 response to hormone AKR1B1, AR, CA2, CA9, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GPER1, PPARA, SRC 3.47786
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 3.44825
[BP] GO:0030335 positive regulation of cell migration DRD1, F10, F3, GPER1, IGF1R, KDR, MET, MMP9, SERPINE1, SRC 3.4186
[BP] GO:0051716 cellular response to stimulus AKR1B1, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, PTPN1, SERPINE1, SRC 3.40419
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AR, AXL, CA1, CA2, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC 3.38674
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, GPER1, GRIK5, GRM1, GRM5, MET 3.35108
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, AR, AURKB, AXL, CA2, CA6, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, PTPN1, SERPINE1, SRC, TYR 3.33742
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SERPINE1, SRC 3.32088
[BP] GO:2000147 positive regulation of cell motility DRD1, F10, F3, GPER1, IGF1R, KDR, MET, MMP9, SERPINE1, SRC 3.30235
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2, GPER1 3.25289
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.2469
[BP] GO:0051272 positive regulation of cellular component movement DRD1, F10, F3, GPER1, IGF1R, KDR, MET, MMP9, SERPINE1, SRC 3.21157
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.18572
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, GPER1, HCAR2, KDR, SRC 3.18572
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, AR, CDC25B, DRD2, ESRRB, FLT3, GPER1, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 3.15654
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.15654
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.15654
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 3.13412
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, AR, AURKB, AXL, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TYR, XDH 3.11308
[BP] GO:0040017 positive regulation of locomotion DRD1, F10, F3, GPER1, IGF1R, KDR, MET, MMP9, SERPINE1, SRC 3.1024
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AR, AXL, CYP1B1, DRD2, ESRRA, F10, F3, FABP4, FLT3, GPER1, GRM1, KDR, MET, MMP2, MMP9, PTPN1, SERPINE1, SRC, XDH 3.1024
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SERPINE1, SRC 3.07388
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CYP1B1, DRD2, ESR1, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SERPINE1, SRC 3.04762
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.04762
[BP] GO:0007268 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.04762
[BP] GO:0098916 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.04762
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, SRC, XDH 3.04666
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 3.04484
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, GPER1, SRC 3.0231
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 3.01918
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CDC25B, DRD2, ESR1, F3, FLT3, GPER1, IGF1R, KDR, MMP2, MMP9, PIM1 3.01828
[BP] GO:0007267 None ADORA1, AR, DRD1, DRD2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.0015
[BP] GO:0099536 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.0015
[BP] GO:0099537 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.0015
[BP] GO:0042391 None ADORA1, DRD1, GPER1, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 2.98644
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, AR, DRD2, FLT3, GPER1, GRM1, KDR, PTPN1, SRC, XDH 2.98307
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AR, AXL, CYP1B1, DRD2, F10, F3, FLT3, GPER1, GRM1, KDR, MET, MMP9, PTPN1, SRC, XDH 2.98307
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, DRD2, FABP3, FLT3, GPER1, GRM5, IGF1R, MMP2, PPARA, SRC, TYR 2.97586
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.96968
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, AOX1, AR, AURKB, AXL, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, SRC, TYR, XDH 2.96678
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AR, AURKB, CDC25B, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPER1, GRM1, GRM5, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SERPINE1, SRC, XDH 2.95987
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, TYR 2.88582
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, AR, CDC25B, DRD1, DRD2, FABP4, FLT3, GPER1, GRM1, GRM5, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.87895
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.87173
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, ESR1, F3, FABP4, GPER1, KDR, MET, PPARA, SERPINE1 2.87173
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, GPER1, HCAR2 2.86051
[BP] GO:0009115 None AOX1, XDH 2.85029
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AR, AURKB, CDC25B, DRD1, DRD2, ESR1, F3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, IGF1R, MMP9, PTPN1, SERPINE1, SRC, XDH 2.82627
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.79474
[BP] GO:1900542 None DRD1, DRD2, ESRRB, GPER1, GRM3, GRM8, PPARA 2.78012
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.7783
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, AR, CDC25B, DRD2, FLT3, GPER1, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 2.77813
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AR, AURKB, CDC25B, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GRM1, GRM5, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SERPINE1, SRC, XDH 2.75966
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 2.71192
[BP] GO:0006140 None DRD1, DRD2, ESRRB, GPER1, GRM3, GRM8, PPARA 2.71192
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD1, DRD2, FABP3, FLT3, GPER1, GRM5, IGF1R, MMP2, PPARA, SRC, TYR 2.70435
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AR, AURKB, CDC25B, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SERPINE1, SRC, XDH 2.66712
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, DRD1, DRD2, ESR1, ESR2, GPER1, IGF1R, MET, MMP9, PTPN1, SERPINE1, SRC, XDH 2.66712
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, AOX1, AR, AURKB, AXL, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SERPINE1, SLC1A1, SRC, TYR, XDH 2.66261
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, DRD1, DRD2, ESR1, ESR2, GPER1, IGF1R, MET, MMP9, PTPN1, SERPINE1, SRC, XDH 2.6559
[BP] GO:0023052 None ADORA1, AR, DRD1, DRD2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.64784
[BP] GO:0030817 None DRD1, DRD2, GPER1, GRM3, GRM8 2.64546
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.64546
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.60636
[BP] GO:0071407 cellular response to organic cyclic compound AR, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, GPER1, SRC 2.59361
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, GPER1, GRIK5, SLC1A1 2.57964
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, IGF1R, KDR, MMP9, PIM1, PTPN1, SERPINE1, SRC 2.55575
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, AR, CYP19A1, DRD1, DRD2, ESR1, ESR2, GPER1, IGF1R, MET, MMP9, PPARA, PTPN1, SERPINE1, SRC, XDH 2.55379
[BP] GO:0043408 regulation of MAPK cascade ADORA1, AR, DRD2, FLT3, GPER1, GRM1, IGF1R, KDR, PTPN1, SRC, XDH 2.55293
[BP] GO:0010676 None ESRRB, GPER1, PPARA, SRC 2.50935
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, GPER1, HCAR2, PPARA, SRC 2.50276
[BP] GO:0007154 None ADORA1, AR, AXL, DRD1, DRD2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.49764
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.48437
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.46923
[BP] GO:0099566 None GRM1, GRM5 2.45665
[BP] GO:0046110 None AOX1, XDH 2.45665
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.45665
[BP] GO:0051240 positive regulation of multicellular organismal process AR, AXL, CA2, CYP1B1, DRD2, ESRRB, F3, GPER1, HCAR2, KDR, MET, MMP9, PIM1, SERPINE1, SLC1A1, SRC 2.42154
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AR, AURKB, CDC25B, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPER1, GRM1, GRM5, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SERPINE1, SRC, XDH 2.41947
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.41373
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 2.38347
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, GPER1, PPARA, SERPINE1 2.38092
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.38092
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.37559
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AR, AURKB, CDC25B, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GRM1, GRM5, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SERPINE1, SRC, XDH 2.37132
[BP] GO:0030814 None DRD1, DRD2, GPER1, GRM3, GRM8 2.35725
[BP] GO:0044093 positive regulation of molecular function ADORA1, AR, AURKB, CDC25B, DRD2, ESR1, ESR2, F3, FLT3, GPER1, GRM1, GRM5, MET, MMP9, PTPN1, SRC, XDH 2.33569
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET 2.32761
[BP] GO:0030802 None DRD1, DRD2, GPER1, GRM3, GRM8 2.31203
[BP] GO:0046777 protein autophosphorylation AURKB, FLT3, IGF1R, KDR, PIM1, SRC 2.30858
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.28967
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, ESR1, GPER1, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.27607
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, DRD2, F10, F3, MET, SERPINE1, XDH 2.26794
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, ESR1, FABP4, GPER1, MMP2, PPARA, PTPN1, SERPINE1, SRC 2.25653
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CYP1A1, CYP1B1, DRD1, DRD2, KDR, SRC 2.25653
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.23948
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR 2.23419
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.23097
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2 2.23044
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 2.22943
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 2.22943
[BP] GO:0006145 None AOX1, XDH 2.22943
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.22943
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.22943
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AR, AURKB, AXL, CA2, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, SERPINE1, SRC, TYR 2.21705
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.21149
[BP] GO:1900371 None DRD1, DRD2, GPER1, GRM3, GRM8 2.19109
[BP] GO:0050801 ion homeostasis CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, GPER1, GRM1, GRM5 2.1829
[BP] GO:0030808 None DRD1, DRD2, GPER1, GRM3, GRM8 2.17865
[BP] GO:0045913 None ESRRB, GPER1, PPARA, SRC 2.1555
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DRD2, ESR1, F3, FABP4, GPER1, IGF1R, MET, MMP2, PPARA, PTPN1, SERPINE1, SRC, XDH 2.15064
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.13614
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AR, AURKB, AXL, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPER1, GRM1, IGF1R, KDR, MET, MMP2, MMP9, PPARA, PTPN1, SERPINE1, SRC, XDH 2.13614
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AR, DRD1, ESR1, FLT3, GPER1, GRM5, IGF1R, MMP2, SRC 2.12367
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.12367
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.12367
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AR, AURKB, AXL, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, GRM3, GRM8, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SERPINE1, SRC, XDH 2.10337
[BP] GO:1900543 None DRD2, GRM3, GRM8, PPARA 2.09735
[BP] GO:0045980 None DRD2, GRM3, GRM8, PPARA 2.07528
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, GPER1, GRIK5, GRM5, HCAR2, MMP9, PPARA, PTPN1, SERPINE1, SRC 2.07077
[BP] GO:0021853 None DRD1, DRD2 2.04735
[BP] GO:0010641 None F3, SRC 2.04735
[BP] GO:0007598 None F10, F3 2.04735
[BP] GO:1904936 None DRD1, DRD2 2.04735
[BP] GO:0042321 None ADORA1, DRD2 2.04735
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.04353
[BP] GO:0071383 None AR, FLT3, GPER1, SRC 2.04353
[BP] GO:0030799 None DRD1, DRD2, GPER1, GRM3, GRM8 2.0325
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, GRM1, MMP2, PPARA, SRC, TYR 2.0325
[BP] GO:0051130 positive regulation of cellular component organization AR, AURKB, AXL, DRD2, ESR1, GPER1, IGF1R, KDR, MET, MMP1, MMP9, SERPINE1, SRC 2.00695
[CC] GO:0042734 None GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.70404
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA9, DRD1, DRD2, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC 4.50064
[CC] GO:0014069 None ADORA1, DRD2, GPER1, GRIK5, GRM1, GRM3, GRM5, SRC 4.10103
[CC] GO:0099572 None ADORA1, DRD2, GPER1, GRIK5, GRM1, GRM3, GRM5, SRC 4.10103
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, AR, AXL, CA12, CA14, CA2, CA9, DRD1, DRD2, ESR1, F10, F3, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SERPINE1, SLC1A1, SRC 3.75865
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, DRD1, DRD2, F10, F3, FLT3, GPER1, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 3.66509
[CC] GO:0044456 None ACHE, ADORA1, DRD2, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 3.27897
[CC] GO:0097060 None GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 3.0873
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, AXL, CA2, CA9, DRD1, DRD2, F10, F3, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SRC 2.87173
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, AR, AXL, CA12, CA14, CA2, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, F10, F3, FLT3, FUT7, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SERPINE1, SLC1A1, SRC, TYR 2.87173
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, DRD1, DRD2, FLT3, GPER1, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 2.80571
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, AXL, CA12, CA14, CA2, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, F10, F3, FLT3, FUT7, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, IGF1R, KDR, MET, PTPN1, SLC1A1, SRC, TYR 2.45193
[CC] GO:0043197 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.32761
[CC] GO:0044309 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.29853
[CC] GO:0043005 None ADORA1, CA2, DRD2, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC 2.23311
[CC] GO:0044432 endoplasmic reticulum part CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, F10, FLT3, GPER1, GRIA2, HSD17B2, PTPN1 2.15064
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, AR, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, TYR, XDH 15.851
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 14.7785
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 9.02098
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA 8.65275
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.22454
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.14651
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 8.14602
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA 7.75731
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSD17B1, SHBG 7.74101
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA 7.53242
[MF] GO:0043167 ion binding ACHE, ALOX5, AOX1, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC1A1, SRC, TYR, XDH 7.28651
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA 6.96806
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1 6.9192
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.9192
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 6.86243
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA 6.62978
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA 6.62978
[MF] GO:0043169 cation binding ACHE, ALOX5, AOX1, AR, AURKB, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC1A1, TYR, XDH 6.23904
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 6.16284
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA 6.16284
[MF] GO:0008289 lipid binding AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, GPER1, HSD17B1, PPARA, SHBG 5.51702
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.36988
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 5.30384
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 5.3032
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, HSD17B2, TYR, XDH 5.24271
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, F3, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 5.1915
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, F3, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 5.1915
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, F10, F3, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC, TYR, XDH 5.15474
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 5.14303
[MF] GO:0046872 metal ion binding ALOX5, AOX1, AR, AURKB, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC1A1, TYR, XDH 4.88175
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 4.77687
[MF] GO:0030594 None DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM5 4.59911
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.5347
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2, GPER1 4.06499
[MF] GO:0042562 hormone binding ACHE, AR, GPER1, HSD17B1, IGF1R, SHBG 4.02513
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, SRC, XDH 3.91461
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.4186
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.2802
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B1, HSD17B2, XDH 3.0231
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.00454
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC 2.87173
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.85029
[MF] GO:0008389 None CYP2A13, CYP2A6 2.85029
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.75966
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.46923
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.45712
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.45665
[MF] GO:0099583 None GRM1, GRM5 2.45665
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.45392
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.45392
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.22943
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.22943
[MF] GO:0004971 None GRIA2, GRIA4 2.22943
[MF] GO:0005497 None AR, SHBG 2.22943
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.22943
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.04735


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA7, CA6, CA9, CA14 16.1632
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.8069
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, ADORA3, GRIK5, GRM8, ADORA1, DRD1, DRD2, GRM1, GRIA4 7.3641
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.5131
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 7.0705
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, GPER1, MMP9, ESR1, GRM1, ESR2 6.1647
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.6155
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.3701
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.3487
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, ADORA1, DRD1, DRD2, PPARA, GRIA4 4.3679
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.5532
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP3A4, CYP19A1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH 3.5789
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, DRD1, DRD2, GRM1 4.0782
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.0806
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.0782
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD1, DRD2 3.815
Pathways in cancer_Homo sapiens_hsa05200 AR, FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.7445
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1, CYP3A4 3.3002
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, SERPINE1, PIM1, F3 2.7428
Adherens junction_Homo sapiens_hsa04520 PTPN1, SRC, MET, IGF1R 3.2036
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3002
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.7428
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.5047
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD1, DRD2, GRIA4 2.3947
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.2494
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 1.9801
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.3354
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, DRD1, GRIA4 2.242
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1661
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.2462
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9801
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.8345
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.6231
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, SERPINE1, F3 2.0644
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.518
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, DRD1, GRM1 1.2764
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.0768
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3741
Prostate cancer_Homo sapiens_hsa05215 AR, IGF1R 1.0973
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0955
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3329
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9508
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3695
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2764
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0597
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.0955
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.0768
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2623
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.991
HIF-1 signaling pathway_Homo sapiens_hsa04066 SERPINE1, IGF1R 1.028
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2764
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3509
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1946
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9508
Oocyte meiosis_Homo sapiens_hsa04114 AR, IGF1R 0.9326
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.8798
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9508
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9446
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8496
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.841
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.2623
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8496
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.7854
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.8005
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.7328
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.7773
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.247
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2945
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3041
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3193
Purine metabolism_Homo sapiens_hsa00230 XDH 0.338
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3379
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3257
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3776
Hippo signaling pathway_Homo sapiens_hsa04390 SERPINE1 0.3769
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3698
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4022
Tight junction_Homo sapiens_hsa04530 SRC 0.4022
Platelet activation_Homo sapiens_hsa04611 SRC 0.4269
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4476
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4099
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4269
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4476
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4269
Axon guidance_Homo sapiens_hsa04360 MET 0.4223
Melanogenesis_Homo sapiens_hsa04916 TYR 0.469
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4862
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4717
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4329
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.469
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4751
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SERPINE1 0.4624
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.4476
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4942
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4751
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4751
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4862
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4862
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4862
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.6343
Peroxisome_Homo sapiens_hsa04146 XDH 0.4942
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4862
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5287
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5455
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5597
Glioma_Homo sapiens_hsa05214 IGF1R 0.5597
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5586
p53 signaling pathway_Homo sapiens_hsa04115 SERPINE1 0.5462
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5597
Shigellosis_Homo sapiens_hsa05131 SRC 0.5597
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7256
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8345
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5597
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.8392
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.6302
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7129
Malaria_Homo sapiens_hsa05144 MET 0.6409
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6469
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7908
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6438
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.3371
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7945
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8105
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.841
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2 0.8703
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8342
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2817


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)