TCM Prescription: Taiyi Plaster



Prescription Description
Prescription IDTCMF1782
Pinyin NameTai Yi Gao
Chinese Name太乙膏
English NameTaiyi Plaster
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1215 Sophora flavescens 苦参 TCMH1215 ITSAM449-14
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH1896 Radix rehmanniae 生地黄 TCMH1896
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.8749
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.8749
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, AKR1C3, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HSD11B1, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, INSR, KDR, MET, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 13.946
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AKR1C3, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 11.8555
[BP] GO:0023056 positive regulation of signaling AKR1B1, AKR1C3, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 11.8515
[BP] GO:0042221 response to chemical AKR1B1, AKR1C3, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSPA1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PTGS2, SMAD3, SRC, TEK 11.8515
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AKR1C3, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 11.4431
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AKR1C3, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 11.2772
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, AKR1C3, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FLT3, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 11.1969
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AKR1C3, ALOX15, AXL, BCL2, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MIF, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 11.118
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AKR1C3, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 10.8759
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSPA1A, HTR1B, HTR5A, IGF1R, INSR, KDR, MMP2, PIK3CA, PTGS2, SMAD3, SRC, TEK 10.6183
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AKR1C3, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 10.3676
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HTR1B, HTR5A, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, SRC, TEK 10.3649
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, PTGS2, SRC 9.91892
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, INSR, PTGS2, SRC, TEK 9.6742
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AKR1C3, ALOX15, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 9.6742
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC, TEK 9.2854
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, AKR1C3, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 9.20254
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, HSD11B2, HTR1B, HTR5A, PTGS2, SRC, TEK 8.96193
[BP] GO:0050896 response to stimulus ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA6, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, F10, FABP3, FABP4, FLT3, HSD11B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS1, PTGS2, SMAD3, SRC, TEK 8.78638
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 8.56436
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1C3, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, MET, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 8.41802
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, BCL2, CSNK2A1, EGFR, ESR1, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK 8.41312
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1C3, ALOX15, ALOX5, ALPL, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, FABP4, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK 8.40415
[BP] GO:0048583 regulation of response to stimulus AKR1B1, AKR1C3, ALOX15, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, FABP4, FLT3, GPR35, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 8.25828
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AKR1C3, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 8.01932
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, AKR1C3, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 7.82472
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1C3, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HSPA1A, HTR2B, HTR2C, MIF, PIK3CA, PIM1, PTGS1, PTGS2, XDH 7.68134
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7, CA9 7.56367
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AKR1C3, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, HTR2B, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 7.39497
[BP] GO:0010941 regulation of cell death AKR1B1, AKR1C3, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 7.39497
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGS1, PTGS2 7.39497
[BP] GO:0097756 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 7.35906
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGS2, SRC 7.23159
[BP] GO:0009966 regulation of signal transduction AKR1B1, AKR1C3, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 7.1992
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, EGFR, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, PTGS2, SRC 7.17638
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 7.17389
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGS1, PTGS2 7.16441
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC, TEK 7.08653
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 7.02947
[BP] GO:0032879 regulation of localization ACHE, ADORA3, ALOX15, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TEK 7.004
[BP] GO:0003018 None EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 6.95924
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK 6.94335
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, BCL2, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 6.93258
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 6.91067
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, BCL2, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 6.88183
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR1B, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PTGS2, SMAD3, SRC 6.84636
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, AKR1C3, CNR1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR2A, HTR2C 6.76138
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, AKR1C3, AXL, BCL2, CA1, CA2, CNR1, CNR2, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, SMAD3, SRC, TEK 6.65423
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.52836
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, AKR1C3, CA2, CNR1, CNR2, ESR1, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, INSR, PIK3CA, PIK3CB, SRC 6.49755
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.45909
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, EGFR, ESR1, FABP3, FABP4, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, PIK3CA, PIK3CB, SMAD3 6.41436
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, INSR, KDR, PIK3CA, SMAD3, SRC, TEK 6.37215
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK 6.37215
[BP] GO:0007187 None CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 6.35378
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 6.31831
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1 6.31831
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MIF, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK 6.2912
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CNR1, EGFR, HTR2A, HTR2B, HTR2C, KDR, MIF, PIK3CB, PTGS2, SRC 6.22637
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, HTR1B, IGF1R, INSR, KDR, MMP2, PIK3CA, PTGS2, SMAD3, SRC 6.21479
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, BCL2, EGFR, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 6.17354
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, BCL2, EGFR, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 6.17354
[BP] GO:0042592 homeostatic process AKR1B1, AXL, BCL2, CA12, CA2, CA7, CNR1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, PIK3CA, PIK3CB, SMAD3, SRC 6.13562
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.11929
[BP] GO:0003013 None EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 5.93605
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 5.90944
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, EGFR, FLT3, HSD11B2, HTR1B, PTGS2, SRC 5.8268
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGS1, PTGS2 5.8268
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, HTR1B, PTGS2, SRC 5.6876
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC, TEK 5.67346
[BP] GO:0032502 developmental process ACHE, AKR1B1, AKR1C3, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD11B1, HTR2A, HTR2B, HTR5A, INSR, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SMAD3, SRC, TEK 5.62513
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, AKR1C3, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 5.58672
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1C3, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, MET, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 5.55803
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, BCL2, EGFR, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 5.39136
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PTGS2, SRC, TEK 5.38515
[BP] GO:0097746 None EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.36546
[BP] GO:0035296 None EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.36546
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.34067
[BP] GO:0030334 regulation of cell migration ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK 5.34067
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TEK, XDH 5.34067
[BP] GO:0040012 regulation of locomotion ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, F10, HTR1D, IGF1R, INSR, KDR, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK 5.29753
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR1B, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, SMAD3, SRC 5.25644
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1 5.25484
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, SRC 5.21789
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.21264
[BP] GO:0050880 None EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.19026
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, CNR2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, SMAD3, SRC, XDH 5.18013
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1 5.17788
[BP] GO:0035150 None EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.17535
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.17191
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, CNR2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, SMAD3, SRC, XDH 5.17191
[BP] GO:0051049 regulation of transport ACHE, ALOX15, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, EGFR, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, MIF, MMP12, MMP9, PIK3CB, PTGS2, SMAD3, SRC 5.16868
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC, TEK 5.15323
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 5.14912
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, PIK3CB, SRC, TEK, XDH 5.03954
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, EGFR, HTR2A, HTR2B, HTR2C, KDR, MIF, SRC, TEK 5.03593
[BP] GO:2000145 regulation of cell motility ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK 5.02302
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 5.01993
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TEK, XDH 5.01655
[BP] GO:0043408 regulation of MAPK cascade ALOX15, DUSP3, EGFR, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, PIK3CB, SRC, TEK, XDH 5.00289
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 4.99724
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, BCL2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 4.98973
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 4.95933
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DUSP3, EGFR, HTR2A, HTR2B, HTR2C, KDR, MIF, SRC, TEK 4.90616
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 4.87022
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.84565
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.81747
[BP] GO:0042325 regulation of phosphorylation ALOX15, BCL2, DUSP3, EGFR, ESRRB, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 4.81533
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.79685
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B1 4.77923
[BP] GO:0019216 regulation of lipid metabolic process AKR1C3, CNR1, CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, PTGS2, SRC, TEK 4.77923
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, BCL2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 4.75089
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, HTR1B 4.73624
[BP] GO:0050790 regulation of catalytic activity ADORA3, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 4.72917
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, HTR1A, MET, MIF, PIK3CB, PIM1, SRC, TEK 4.71157
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.71121
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 4.68927
[BP] GO:0050795 None CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 4.67643
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PTGS1, PTGS2 4.64398
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 4.63323
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, MMP9, SRC 4.63323
[BP] GO:0051270 regulation of cellular component movement ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK 4.61705
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1C3, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, XDH 4.60665
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.60528
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, SMAD3, SRC, TEK 4.58318
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, MET, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 4.57651
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.56442
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH 4.50263
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 4.49869
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 4.48834
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, MIF, PTGS1, PTGS2 4.46742
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.46637
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 4.45692
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 4.42104
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 4.39142
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.38654
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 4.38654
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, BCL2, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 4.3751
[BP] GO:0031399 regulation of protein modification process ALOX15, BCL2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 4.3751
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, EGFR, HSD11B2, HSPA1A, HTR1A, HTR2C, MIF, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS1, PTGS2, SMAD3, SRC, TEK 4.33024
[BP] GO:0048585 negative regulation of response to stimulus ALOX15, BCL2, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, SMAD3, SRC, TEK, XDH 4.31904
[BP] GO:0007193 None HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 4.30209
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2 4.30209
[BP] GO:0065009 regulation of molecular function ADORA3, AURKB, BCL2, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 4.25899
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.22202
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, MIF, PIK3CB, SRC 4.17386
[BP] GO:0065007 biological regulation ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GPR35, HSD11B1, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 4.16098
[BP] GO:0003008 None AKR1B1, AKR1C3, BCL2, CNR1, CNR2, CYP1B1, EGFR, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, INSR, PIK3CA, PTGS2, SRC, TEK 4.14143
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, BCL2, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 4.14143
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, AKR1C3, ALOX15, ALPL, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HTR5A, INSR, KDR, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK 4.13894
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, ESRRB, HSPA1A, HTR2A, HTR2B, KDR, MET, MIF, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK 4.13248
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.11589
[BP] GO:0031325 positive regulation of cellular metabolic process AKR1C3, ALOX15, AURKB, BCL2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 4.10298
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 4.10282
[BP] GO:0007154 None AKR1C3, AXL, BCL2, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2, TEK 4.10244
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, HSD11B2, HSPA1A, HTR1B, HTR2A, HTR2B, MMP2, PTGS2, SMAD3, SRC, TEK 4.04985
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, EGFR, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PTGS2, SRC, TEK 4.04959
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.01926
[BP] GO:0043271 negative regulation of ion transport BCL2, CNR1, GPR35, HTR1B, HTR2A, MMP9, PTGS2 3.96448
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.96214
[BP] GO:0009893 positive regulation of metabolic process AKR1C3, ALOX15, AURKB, BCL2, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 3.95776
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process AKR1C3, EGFR, INSR, PTGS2, SMAD3, XDH 3.92748
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, SRC 3.92179
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, AURKB, BCL2, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 3.91875
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 3.91718
[BP] GO:0080134 regulation of response to stress CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PTGS2, SMAD3, SRC, TEK, XDH 3.84056
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTGS2, SRC 3.80325
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.74892
[BP] GO:0099536 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.74258
[BP] GO:0099537 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.74258
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, CA2, CA7, CNR1, CNR2, EGFR, HTR1B, HTR2A, PTGS2 3.723
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, CA2, CA7, CNR1, CNR2, EGFR, HTR1B, HTR2A, PTGS2 3.723
[BP] GO:0031401 positive regulation of protein modification process ALOX15, BCL2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 3.71433
[BP] GO:0007188 None CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 3.7082
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, EGFR, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PTGS2, SRC, TEK 3.70349
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.67421
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.67421
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.67421
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.67421
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.62627
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 3.61736
[BP] GO:0006693 None AKR1C3, MIF, PTGS1, PTGS2 3.616
[BP] GO:0006692 None AKR1C3, MIF, PTGS1, PTGS2 3.616
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, AURKB, BCL2, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 3.59093
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, EGFR, HTR1B, HTR2A, PTGS2 3.58326
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.51629
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, AKR1C3, ALOX15, AURKB, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 3.5004
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MIF, MMP9, PTGS2, SRC, XDH 3.49221
[BP] GO:0009892 negative regulation of metabolic process AKR1C3, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PTGS2, SMAD3, SRC, XDH 3.4536
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, MIF, PTGS1, PTGS2 3.43663
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, CNR2, HTR1B, HTR2A, PTGS2 3.42821
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.42821
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.42821
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, SRC 3.41712
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 3.38766
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, SRC 3.37275
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, SMAD3 3.3662
[BP] GO:0071276 cellular response to cadmium ion AKR1C3, CYP1A2, EGFR, MMP9 3.33589
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PTGS2, SRC 3.30534
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SMAD3, SRC, TEK 3.30324
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.29354
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, BCL2, CNR1, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 3.28683
[BP] GO:0032101 regulation of response to external stimulus CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, KDR, MET, MIF, MMP12, PTGS2, SMAD3, TEK 3.25264
[BP] GO:0050900 leukocyte migration CNR2, FUT7, MIF, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.25264
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, SRC 3.25264
[BP] GO:0043406 positive regulation of MAP kinase activity EGFR, FLT3, HTR2A, HTR2B, INSR, MIF, PIK3CB, SRC 3.25233
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.24284
[BP] GO:0010863 positive regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B 3.24077
[BP] GO:0031347 regulation of defense response CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PTGS2, SMAD3, SRC, TEK 3.23852
[BP] GO:0009894 regulation of catabolic process BCL2, CNR1, CSNK2A1, EGFR, ESRRB, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB, SMAD3 3.2344
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SMAD3, SRC, TEK 3.22601
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, HTR5A, PTGS2 3.22601
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.21123
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 3.20912
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B1 3.1908
[BP] GO:0019371 None AKR1C3, PTGS1, PTGS2 3.18069
[BP] GO:1903530 regulation of secretion by cell ACHE, CNR1, CYP19A1, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, SRC 3.15827
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2 3.15623
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, EGFR, ESR1, FLT3, HTR1B, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC 3.155
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, AXL, BCL2, CNR1, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, INSR, MMP2, MMP9, PTGS2, SRC 3.13679
[BP] GO:0032268 regulation of cellular protein metabolic process ALOX15, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 3.13678
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 3.12543
[BP] GO:1900274 regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B 3.11002
[BP] GO:0009056 catabolic process ACHE, AKR1C3, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.11002
[BP] GO:0090066 None ALOX15, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.11002
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, FABP4, KDR, MET, MIF, PTGS2, SMAD3 3.10884
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.07815
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, HTR1B, KDR, PTGS2, SRC 3.07815
[BP] GO:0045759 None CNR1, CNR2, GPR35 3.07692
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, EGFR, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MET, MIF, NUAK1, PIK3CA, PIK3CB, SRC, TEK 3.074
[BP] GO:0002682 regulation of immune system process ALOX15, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, DUSP3, ESR1, ESRRA, HSPA1A, MIF, MMP12, MMP2, PIK3CA, PIK3CB, SMAD3, SRC 3.07161
[BP] GO:0050789 regulation of biological process ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 3.06823
[BP] GO:0080090 regulation of primary metabolic process ADORA3, AKR1C3, ALOX15, AURKB, BCL2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 3.04591
[BP] GO:0006928 movement of cell or subcellular component AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK 3.04591
[BP] GO:0032787 None AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PTGS1, PTGS2 3.04248
[BP] GO:1901570 None ALOX15, ALOX5, MIF, PTGS1, PTGS2 3.02147
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA3, AKR1C3, ALOX15, AURKB, BCL2, CA9, CNR1, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 3.00757
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SMAD3, SRC, TEK 2.99607
[BP] GO:0007208 None HTR2A, HTR2C 2.99607
[BP] GO:0009115 None AOX1, XDH 2.99607
[BP] GO:0007268 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.99494
[BP] GO:0098916 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.99494
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2 2.99454
[BP] GO:0001516 None MIF, PTGS1, PTGS2 2.99322
[BP] GO:0046457 None MIF, PTGS1, PTGS2 2.99322
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AXL, BCL2, CYP19A1, EGFR, ESR1, ESRRB, INSR, PTGS2, SRC 2.98753
[BP] GO:0050727 regulation of inflammatory response CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, PTGS2, SMAD3, TEK 2.97576
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 2.96352
[BP] GO:0043549 regulation of kinase activity DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, MIF, PIK3CA, PIK3CB, SRC, TEK 2.95662
[BP] GO:0043269 regulation of ion transport BCL2, CA2, CA7, CNR1, GPR35, HTR1A, HTR1B, HTR2A, MIF, MMP9, PTGS2 2.93443
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.93144
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.93144
[BP] GO:0032845 None BCL2, HTR2A, HTR2B, HTR2C, MIF, SRC 2.92525
[BP] GO:0009987 cellular process ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GPR35, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 2.915
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.9084
[BP] GO:0051046 None ACHE, CNR1, CYP19A1, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, SRC 2.9084
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.9084
[BP] GO:0044093 positive regulation of molecular function AURKB, BCL2, EGFR, ESR1, ESR2, FLT3, HSPA1A, HTR2A, HTR2B, INSR, MET, MIF, MMP9, PIK3CA, PIK3CB, SMAD3, SRC, TEK, XDH 2.9084
[BP] GO:0071900 regulation of protein serine/threonine kinase activity DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, MIF, PIK3CB, SRC 2.90333
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.90333
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.8601
[BP] GO:0031667 response to nutrient levels AKR1C3, ALPL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, SRC 2.85296
[BP] GO:0007267 None CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, TEK 2.84027
[BP] GO:0050999 None CNR1, CNR2, EGFR, HTR2B 2.83272
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.83272
[BP] GO:0055080 cation homeostasis BCL2, CA2, CA7, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 2.83272
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, EGFR, PIK3CB, PTGS2 2.82664
[BP] GO:0051338 regulation of transferase activity AURKB, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, MIF, PIK3CA, PIK3CB, SRC, TEK 2.82298
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, AURKB, BCL2, CNR1, CSNK2A1, DUSP3, ESR1, ESR2, ESRRA, FABP4, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, MET, MIF, MMP12, MMP9, PIK3CA, PTGS2, SMAD3, SRC, XDH 2.8029
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HTR2A, MIF, PTGS2 2.77083
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 2.76325
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3 2.76325
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.75531
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.75531
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.75531
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 2.74945
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, EGFR, FABP3, KDR, MMP2, PTGS2, SRC 2.74742
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTGS2, SRC 2.73634
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, SMAD3, SRC, XDH 2.71673
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.70185
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA2, CA7, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, SMAD3 2.69892
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.68147
[BP] GO:0007610 None BCL2, CNR1, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, PTGS2 2.67832
[BP] GO:0010518 positive regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B 2.67342
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3 2.66415
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation BCL2, EGFR, MIF, PIK3CA, PTGS2 2.65834
[BP] GO:0006954 inflammatory response ADORA3, ALOX15, AXL, CNR2, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 2.65028
[BP] GO:0045859 regulation of protein kinase activity DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, MIF, PIK3CA, PIK3CB, SRC 2.6446
[BP] GO:0033674 positive regulation of kinase activity EGFR, FLT3, HTR2A, HTR2B, INSR, MIF, PIK3CA, PIK3CB, SRC, TEK 2.63399
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX15, ALOX5, CYP19A1, CYP1A1, MIF, PTGS1, PTGS2 2.62417
[BP] GO:0046890 None AKR1C3, FABP3, HTR2A, HTR2B, HTR2C, PTGS2 2.62192
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, SMAD3, SRC, TEK 2.62086
[BP] GO:0045821 None ESRRB, HTR2A, INSR 2.62086
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.61001
[BP] GO:0046110 None AOX1, XDH 2.61001
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.61001
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.58963
[BP] GO:0051246 regulation of protein metabolic process ALOX15, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 2.58474
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 2.56852
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.56017
[BP] GO:0051197 None ESRRB, HTR2A, INSR 2.56017
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, HTR1A, INSR, PTGS2, SMAD3 2.54463
[BP] GO:0051347 positive regulation of transferase activity AURKB, EGFR, FLT3, HTR2A, HTR2B, INSR, MIF, PIK3CA, PIK3CB, SRC, TEK 2.54366
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.54159
[BP] GO:1901652 response to peptide AKR1B1, FABP3, HSD11B2, IGF1R, INSR, PTGS2, SRC, TEK 2.54141
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 2.53842
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.53828
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.53828
[BP] GO:0030003 cellular cation homeostasis BCL2, CA2, CA7, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 2.53726
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, SRC 2.53458
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity EGFR, FLT3, HTR2A, HTR2B, INSR, MIF, PIK3CB, SRC 2.53216
[BP] GO:0006721 terpenoid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, EGFR 2.53216
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.51561
[BP] GO:0008406 gonad development AKR1C3, BCL2, CYP19A1, ESR1, INSR 2.51561
[BP] GO:0032768 None CNR1, CNR2, EGFR, HTR2B 2.51561
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.50454
[BP] GO:0001775 cell activation ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MIF, MMP9, PIK3CA, PIK3CB, SMAD3, SRC 2.50454
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSPA1A, HTR1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 2.5029
[BP] GO:0023052 None CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, TEK 2.49121
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, EGFR, MMP9 2.49121
[BP] GO:0051050 positive regulation of transport ACHE, AXL, BCL2, CA2, CYP19A1, EGFR, HTR2B, INSR, MIF, MMP12, PTGS2, SMAD3, SRC 2.49048
[BP] GO:0009895 negative regulation of catabolic process BCL2, CNR1, EGFR, HTR2B, MET, PIK3CA, SMAD3 2.48439
[BP] GO:0006873 cellular ion homeostasis BCL2, CA2, CA7, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 2.46629
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.46623
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.46623
[BP] GO:0051094 positive regulation of developmental process AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, HTR2A, HTR2C, INSR, KDR, PIM1, PTGS2, SMAD3, SRC, TEK 2.46285
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.45694
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.45694
[BP] GO:0050793 regulation of developmental process AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, HTR2A, HTR2C, INSR, KDR, MIF, NUAK1, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 2.45642
[BP] GO:0043085 positive regulation of catalytic activity AURKB, BCL2, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, INSR, MIF, PIK3CA, PIK3CB, SMAD3, SRC, TEK, XDH 2.45107
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1 2.42335
[BP] GO:0048608 reproductive structure development AKR1C3, AXL, BCL2, CYP19A1, ESR1, INSR, SRC 2.42335
[BP] GO:0010517 regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B 2.41671
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.4039
[BP] GO:0051194 None ESRRB, HTR2A, INSR 2.4039
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.4039
[BP] GO:0006145 None AOX1, XDH 2.36352
[BP] GO:0038171 None CNR1, CNR2 2.36352
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.36352
[BP] GO:0014827 None HTR1D, HTR2B 2.36352
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.35159
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.35159
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK 2.3504
[BP] GO:0060193 positive regulation of lipase activity EGFR, ESR1, HTR2A, HTR2B 2.34544
[BP] GO:0007584 response to nutrient AKR1C3, ALPL, CNR1, CYP1A1, EGFR, PTGS2 2.34081
[BP] GO:0043065 positive regulation of apoptotic process AKR1C3, BCL2, CNR1, CYP1B1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, XDH 2.3298
[BP] GO:0006874 cellular calcium ion homeostasis BCL2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 2.3255
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, HTR7, SRC 2.30787
[BP] GO:0051894 None KDR, SMAD3, TEK 2.30787
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.30787
[BP] GO:0007202 None EGFR, HTR2A, HTR2B 2.30787
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.30787
[BP] GO:0043068 positive regulation of programmed cell death AKR1C3, BCL2, CNR1, CYP1B1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, XDH 2.30366
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, PTGS2, SMAD3, SRC 2.28457
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.27902
[BP] GO:0007166 cell surface receptor signaling pathway ADORA3, AXL, BCL2, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, SMAD3, SRC, TEK 2.27184
[BP] GO:0006720 isoprenoid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, EGFR 2.26567
[BP] GO:0050776 regulation of immune response ALOX15, BCL2, CNR1, DUSP3, ESR1, HSPA1A, MIF, MMP12, MMP2, PIK3CA, PIK3CB, SMAD3, SRC 2.26567
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA3, ALOX15, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 2.26225
[BP] GO:0055074 calcium ion homeostasis BCL2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 2.24922
[BP] GO:0019637 organophosphate metabolic process ACHE, ALOX15, CSNK2A1, EGFR, HSPA1A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, PTGS2, XDH 2.24674
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, EGFR, HTR1B, IGF1R, INSR, MMP2, PTGS2, SRC 2.23693
[BP] GO:0001819 positive regulation of cytokine production CYP1B1, HSPA1A, HTR2B, MIF, MMP12, PTGS2, SMAD3, SRC 2.23693
[BP] GO:0072503 cellular divalent inorganic cation homeostasis BCL2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 2.21704
[BP] GO:1903393 None KDR, SMAD3, TEK 2.21704
[BP] GO:0045913 None ESRRB, HTR2A, INSR, SRC 2.21511
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.21203
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, SRC 2.19879
[BP] GO:0045860 positive regulation of protein kinase activity EGFR, FLT3, HTR2A, HTR2B, INSR, MIF, PIK3CA, PIK3CB, SRC 2.19863
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, BCL2, EGFR, HTR2B, MIF, MMP12, PTGS2, SMAD3, SRC 2.19511
[BP] GO:0033135 regulation of peptidyl-serine phosphorylation BCL2, EGFR, MIF, PIK3CA, PTGS2 2.18787
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.18571
[BP] GO:0071502 None HTR1B, HTR2B 2.18571
[BP] GO:0002683 negative regulation of immune system process ALOX15, AXL, CNR1, CNR2, CYP19A1, DUSP3, MIF, MMP12 2.17292
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTGS2, SRC 2.16927
[BP] GO:0010507 negative regulation of autophagy BCL2, HTR2B, MET, PIK3CA 2.159
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, MIF, PIK3CB 2.13867
[BP] GO:0014059 None CNR1, HTR1B, HTR2A 2.13867
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, MET, SMAD3, SRC 2.1304
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.1304
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1C3, AOX1, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A 2.12867
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.12638
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1C3, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, HTR1A 2.12419
[BP] GO:0031329 regulation of cellular catabolic process BCL2, CNR1, ESRRB, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB 2.12419
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.12036
[BP] GO:0019725 cellular homeostasis BCL2, CA2, CA7, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, SMAD3 2.11156
[BP] GO:0071383 None AKR1C3, EGFR, FLT3, SRC 2.10192
[BP] GO:0031349 positive regulation of defense response CNR1, EGFR, FABP4, HSPA1A, MMP12, MMP2, PTGS2, SRC 2.10192
[BP] GO:0010942 positive regulation of cell death AKR1C3, BCL2, CNR1, CYP1B1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, XDH 2.08303
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.06508
[BP] GO:0002209 None BCL2, HTR1A, HTR2C 2.06508
[BP] GO:0001662 None BCL2, HTR1A, HTR2C 2.06508
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.06508
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.06508
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.06508
[BP] GO:0009605 response to external stimulus AKR1C3, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, EGFR, HSD11B2, HTR2A, MMP12, PTGS2, SMAD3, SRC 2.04906
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3 2.04809
[BP] GO:0055065 metal ion homeostasis BCL2, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 2.04809
[BP] GO:0031334 positive regulation of protein complex assembly ALOX15, ESR1, HSPA1A, MET, MMP1, SRC 2.04809
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, EGFR, HTR1B, IGF1R, INSR, MMP2, PTGS2, SRC 2.04809
[BP] GO:0010760 negative regulation of macrophage chemotaxis CYP19A1, MIF 2.04809
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.04809
[BP] GO:0046113 None AOX1, XDH 2.04809
[BP] GO:0014831 None HTR1D, HTR2B 2.04809
[BP] GO:0032229 None CNR2, HTR1B 2.04809
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.04809
[BP] GO:1901890 None KDR, SMAD3, TEK 2.03569
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, PTGS2, SMAD3, SRC 2.03233
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, AXL, BCL2, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, HTR2B, KDR, MET, MIF, MMP2, MMP9, PTGS2, SMAD3, SRC, TEK 2.02103
[BP] GO:0090087 None ACHE, CA2, CNR1, EGFR, HTR2B, HTR2C, MIF, MMP12, PTGS2, SMAD3, SRC 2.01568
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.01568
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, AXL, CA4, CNR1, CNR2, F10, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 6.92922
[CC] GO:0044459 plasma membrane part ADORA3, ALOX15, AXL, CA2, CA4, CA9, CNR1, CNR2, DUSP3, EGFR, F10, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTGS2, SRC, TEK 6.2912
[CC] GO:0005886 plasma membrane ACHE, ADORA3, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, EGFR, ESR1, F10, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, SMAD3, SRC, TEK 6.14184
[CC] GO:0005887 integral component of plasma membrane ADORA3, AXL, CNR1, CNR2, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 5.89402
[CC] GO:0044425 membrane part ACHE, ADORA3, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GPR35, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, SRC, TEK 4.37944
[CC] GO:0016020 membrane ACHE, ADORA3, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, F10, FLT3, FUT7, GPR35, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK 4.28389
[CC] GO:0045121 membrane raft CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 2.98986
[CC] GO:0098857 membrane microdomain CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 2.97273
[CC] GO:0098589 membrane region CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 2.51137
[CC] GO:0005901 caveola HTR2A, INSR, PTGS2, SRC 2.159
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.8749
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.8749
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.728
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.728
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.4528
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 13.7577
[MF] GO:0008227 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 12.4567
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 12.4567
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 11.2526
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, SMAD3, XDH 11.1864
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.87012
[MF] GO:0038023 signaling receptor activity ADORA3, AXL, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 9.687
[MF] GO:0030594 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 9.67224
[MF] GO:0004872 receptor activity ADORA3, AXL, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 8.56436
[MF] GO:0004871 signal transducer activity ADORA3, AXL, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SMAD3, TEK 8.41312
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PTGS1, PTGS2, SMAD3, XDH 8.41312
[MF] GO:0060089 molecular transducer activity ADORA3, AXL, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 8.31099
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.84367
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SRC, TEK, XDH 7.80352
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 7.63261
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.46357
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, CNR1, CNR2, EGFR, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 7.39497
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, CNR1, CNR2, EGFR, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 7.39497
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 6.91995
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.76138
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, SMAD3 5.82902
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1C3, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, XDH 5.65878
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.29753
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 5.00585
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 4.7168
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 4.65282
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.58318
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 4.50263
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 4.26514
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 4.20453
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.16057
[MF] GO:0004930 None ADORA3, CNR1, CNR2, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 4.09208
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1C3, AOX1, HSD11B1, HSD11B2, HSD17B1, XDH 4.05547
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2 4.05547
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.03176
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 4.02322
[MF] GO:1901363 heterocyclic compound binding AOX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 3.83509
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.80325
[MF] GO:0097159 organic cyclic compound binding AOX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 3.74258
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.723
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.616
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD11B2, HSD17B1 3.55307
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.52083
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD11B2, HSD17B1 3.43663
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.42821
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.39008
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PTGS1, PTGS2, SMAD3, XDH 3.38766
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.99607
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.99607
[MF] GO:0003845 None HSD11B1, HSD11B2 2.99607
[MF] GO:0071886 None HTR2A, HTR2C 2.99607
[MF] GO:0044877 macromolecular complex binding ACHE, CSNK2A1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, SMAD3, SRC 2.93135
[MF] GO:0036094 small molecule binding AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH 2.90074
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH 2.85253
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH 2.85071
[MF] GO:0016903 None AKR1B1, AKR1C3, AOX1, XDH 2.83272
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.79904
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.73252
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB 2.67342
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB 2.67342
[MF] GO:0032403 protein complex binding ACHE, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, SMAD3, SRC 2.6257
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.61001
[MF] GO:0004949 None CNR1, CNR2 2.61001
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, HSD11B2, HSD17B1 2.58863
[MF] GO:0043168 anion binding ALOX15, AOX1, AURKB, AXL, CSNK2A1, EGFR, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH 2.53458
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB 2.41671
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.36352
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1C3, HSD11B1, HSD11B2, HSD17B1 2.34953
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.32258
[MF] GO:0042802 identical protein binding ACHE, AOX1, BCL2, CSNK2A1, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MIF, MMP9, NQO2, PTGS2, SMAD3, XDH 2.32258
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.29661
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.25799
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.21704
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.19879
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.19702
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, MET, PIK3CA, PIK3CB 2.1961
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.18571
[MF] GO:0043559 insulin binding IGF1R, INSR 2.18571
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.18026
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.17292
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.10192
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.10192
[MF] GO:0104005 hijacked molecular function AXL, EGFR, HSPA1A, HTR2A 2.06508
[MF] GO:0001618 virus receptor activity AXL, EGFR, HSPA1A, HTR2A 2.06508
[MF] GO:0004064 arylesterase activity CA1, CA2 2.04809
[MF] GO:0043546 None AOX1, XDH 2.04809


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 16.9686
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, GPR35, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3 11.4848
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 11.2314
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14 13.4156
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, ESR2, HSPA1A 8.6297
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP19A1 8.9682
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 7.1403
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 7.0366
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, EGFR, IGF1R 6.5235
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.7908
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 5.7897
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, PIK3CB, PTGS2, PTGS1 6.1252
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, BCL2, TEK, PIK3CB, EGFR, IGF1R 5.9104
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2C, HTR2A, HTR5A, HTR4, EGFR 5.4833
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, PIK3CA, HTR1E, HTR1D, HTR1A, HTR1B, PIK3CB, HTR4 5.2099
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 5.1871
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB 4.8271
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PIK3CB, HTR2A 4.8807
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, INSR, KDR, BCL2, TEK, PIK3CB, MET, EGFR, IGF1R 4.5669
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.4101
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.66
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.5972
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, AKR1C3, PTGS2, PTGS1 4.6459
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.429
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR 4.1944
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 4.2865
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.416
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.5361
Hepatitis B_Homo sapiens_hsa05161 SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 4.129
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1C3, AKR1B1, PTGS2, CYP19A1, PTGS1, HSD11B1, FUT7, ALOX5, HSD17B1, CYP1A2, CYP1A1, AOX1, ALPL, XDH 3.8303
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.7251
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 4.0811
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.1944
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2C, HTR2A, EGFR 4.092
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.5402
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 3.2249
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 3.0562
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 3.0562
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 3.4468
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.6373
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, INSR, PIK3CB 4.1944
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.4316
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.5163
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 3.0953
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.6207
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.6853
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.6853
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.0562
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.9333
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.2816
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 3.0531
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.1898
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.1759
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.5777
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.6169
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.6169
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, PIK3CB 2.5972
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.4247
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.5588
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PIK3CB, EGFR 2.354
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, PIK3CB 2.153
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0432
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.8315
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.549
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, IGF1R 1.9527
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.585
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 2.0251
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 1.9223
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, INSR, PIK3CB 1.8474
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.7442
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, INSR, PIK3CB 1.5882
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB 1.5129
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, EGFR 1.6341
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.5309
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.307
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.8928
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3195
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB, HSPA1A 1.3678
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.2142
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3611
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.0046
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.2711
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4022
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.3102
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 1.0259
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.4227
Axon guidance_Homo sapiens_hsa04360 MET 0.4175
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4227
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, PIK3CB 1.0179
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.8024
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.9201
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9062
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.3705
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7696
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.9329
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.902
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.6169
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0821
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5082
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5074
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0926
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.158
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.1145
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.1256
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.3828
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.111
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5303
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.3464
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5303
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5414
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5291
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1793
Peroxisome_Homo sapiens_hsa04146 XDH 0.5427
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.3347
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB, EGFR 2.5563
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5581
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5784
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5646
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.6853
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5764
Bile secretion_Homo sapiens_hsa04976 CA2 0.5859
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.3317
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.3703
Shigellosis_Homo sapiens_hsa05131 SRC 0.6164
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3495
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.6164
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6409
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.3678
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.4622
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6442
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6682
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6946
Malaria_Homo sapiens_hsa05144 MET 0.7071
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7169
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.712
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7219
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6641
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8182
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8703
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8604
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.9024
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.8102
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8511
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8804
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF 1.8536
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9066
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.991
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9024
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1602
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 1.0644
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1256
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.4378
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.323


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)