Molecular Weight:   | 240.08 |
Volume:   | 256.162 |
LogP:   | 3.283 |
LogD:   | 3.105 |
LogS:   | -3.635 |
# Rotatable Bonds:   | 3 |
TPSA:   | 57.53 |
# H-Bond Aceptor:   | 3 |
# H-Bond Donor:   | 2 |
# Rings:   | 2 |
# Heavy Atoms:   | 3 |
QED Drug-Likeness Score:   | 0.64 |
Synthetic Accessibility Score:   | 1.896 |
Fsp3:   | 0.0 |
Lipinski Rule-of-5:   | Accepted |
Pfizer Rule:   | Rejected |
GSK Rule:   | Accepted |
BMS Rule:   | 0 |
Golden Triangle Rule:   | Accepted |
Chelating Alert:   | 0 |
PAINS Alert:   | 0 |
Caco-2 Permeability:   | -4.789 |
MDCK Permeability:   | 1.2228045306983404e-05 |
Pgp-inhibitor:   | 0.005 |
Pgp-substrate:   | 0.001 |
Human Intestinal Absorption (HIA):   | 0.034 |
20% Bioavailability (F20%):   | 0.816 |
30% Bioavailability (F30%):   | 0.584 |
Blood-Brain-Barrier Penetration (BBB):   | 0.117 |
Plasma Protein Binding (PPB):   | 99.3736572265625% |
Volume Distribution (VD):   | 0.567 |
Pgp-substrate:   | 0.7889693379402161% |
CYP1A2-inhibitor:   | 0.986 |
CYP1A2-substrate:   | 0.088 |
CYP2C19-inhibitor:   | 0.804 |
CYP2C19-substrate:   | 0.056 |
CYP2C9-inhibitor:   | 0.726 |
CYP2C9-substrate:   | 0.957 |
CYP2D6-inhibitor:   | 0.865 |
CYP2D6-substrate:   | 0.82 |
CYP3A4-inhibitor:   | 0.882 |
CYP3A4-substrate:   | 0.163 |
Clearance (CL):   | 11.672 |
Half-life (T1/2):   | 0.841 |
hERG Blockers:   | 0.076 |
Human Hepatotoxicity (H-HT):   | 0.039 |
Drug-inuced Liver Injury (DILI):   | 0.504 |
AMES Toxicity:   | 0.652 |
Rat Oral Acute Toxicity:   | 0.272 |
Maximum Recommended Daily Dose:   | 0.193 |
Skin Sensitization:   | 0.928 |
Carcinogencity:   | 0.661 |
Eye Corrosion:   | 0.319 |
Eye Irritation:   | 0.989 |
Respiratory Toxicity:   | 0.163 |
Natural Product ID:   | NPC297186 |
Common Name*:   | 2',4'-Dihydroxychalcone |
IUPAC Name:   | (E)-1-(2,4-dihydroxyphenyl)-3-phenylprop-2-en-1-one |
Synonyms:   | (E)-2',4'-Dihydroxychalcone; 2',4'-Dihydroxychalcone |
Standard InCHIKey:   | JUMSUVHHUVPSOY-RMKNXTFCSA-N |
Standard InCHI:   | InChI=1S/C15H12O3/c16-12-7-8-13(15(18)10-12)14(17)9-6-11-4-2-1-3-5-11/h1-10,16,18H/b9-6+ |
SMILES:   | c1ccc(cc1)/C=C/C(=O)c1ccc(cc1O)O |
Synthetic Gene Cluster:   | n.a. |
ChEMBL Identifier:   | CHEMBL105310 |
PubChem CID:   |
5376979 |
Chemical Classification**:   |
|
*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.
Organism ID | Organism Name | Taxonomy Level | Family | SuperKingdom | Isolation Part | Collection Location | Collection Time | Reference |
---|---|---|---|---|---|---|---|---|
NPO784 | Sinapis alba | Species | Brassicaceae | Eukaryota | n.a. | seed | n.a. | DOI[10.1007/s11418-005-0009-z] |
NPO20440 | Chrysanthemum x morifolium | Species | Asteraceae | Eukaryota | Flowers | n.a. | n.a. | DOI[10.1016/j.foodchem.2009.03.042] |
NPO20440 | Chrysanthemum x morifolium | Species | Asteraceae | Eukaryota | Flowers | n.a. | n.a. | DOI[10.3136/fstr.15.499] |
NPO20440 | Chrysanthemum x morifolium | Species | Asteraceae | Eukaryota | Flowers | n.a. | n.a. | DOI[10.5897/AJB10.140] |
NPO20440 | Chrysanthemum x morifolium | Species | Asteraceae | Eukaryota | Flowers | n.a. | n.a. | DOI[10.5897/AJB2010.000-3252] |
NPO22258 | Chrysanthemum indicum | Species | Asteraceae | Eukaryota | Flowers | n.a. | n.a. | DOI[10.5897/JMPR.9000078] |
NPO1086 | Botrytis cinerea | Species | Sclerotiniaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[10691704] |
NPO22258 | Chrysanthemum indicum | Species | Asteraceae | Eukaryota | n.a. | flower | n.a. |
PMID[12130858] |
NPO32673 | zuccagnia punctata | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[15161186] |
NPO1086 | Botrytis cinerea | Species | Sclerotiniaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[16378371] |
NPO1086 | Botrytis cinerea | Species | Sclerotiniaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[16643065] |
NPO33288 | Brazilian Red Propolis | Strain | n.a. | n.a. | n.a. | Brazilian | n.a. |
PMID[17950610] |
NPO8025 | Aaptos ciliata | Species | Suberitidae | Eukaryota | n.a. | n.a. | n.a. |
PMID[18257536] |
NPO33288 | Brazilian Red Propolis | Strain | n.a. | n.a. | n.a. | Brazilian | n.a. |
PMID[18440233] |
NPO5325 | Lobophytum durum | Species | Alcyoniidae | Eukaryota | n.a. | n.a. | n.a. |
PMID[19177635] |
NPO5325 | Lobophytum durum | Species | Alcyoniidae | Eukaryota | n.a. | n.a. | n.a. |
PMID[19433363] |
NPO20812 | Soymida febrifuga | Species | Meliaceae | Eukaryota | n.a. | Myanmar | n.a. |
PMID[19689125] |
NPO26507 | Galenia africana | Species | Aizoaceae | Eukaryota | leaf | n.a. | n.a. |
PMID[20035557] |
NPO2765 | Oxytropis falcata | Species | Fabaceae | Eukaryota | n.a. | Sunan County, Gansu Province, China | 2006-JUN |
PMID[20684529] |
NPO5885 | Bathymodiolus thermophilus | Species | Mytilidae | Eukaryota | n.a. | gill | n.a. |
PMID[21222464] |
NPO5608 | Croton gratissimus | Species | Euphorbiaceae | Eukaryota | n.a. | stem | n.a. |
PMID[22032651] |
NPO5608 | Croton gratissimus | Species | Euphorbiaceae | Eukaryota | n.a. | leaf | n.a. |
PMID[22032651] |
NPO2765 | Oxytropis falcata | Species | Fabaceae | Eukaryota | whole plant | Guide County, Qinghai Province, China | 2008-AUG |
PMID[22775441] |
NPO20440 | Chrysanthemum x morifolium | Species | Asteraceae | Eukaryota | Flowers | Tongxiang, China | n.a. |
PMID[24621197] |
NPO22258 | Chrysanthemum indicum | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[26099993] |
NPO40183 | Leishmania amazonensis | Species | Trypanosomatidae | Eukaryota | n.a. | n.a. | n.a. |
PMID[26169126] |
NPO19152 | Empetrum nigrum | Species | Ericaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[26473275] |
NPO25653 | Spatholobus suberectus | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[26690274] |
NPO33288 | Brazilian Red Propolis | Strain | n.a. | n.a. | n.a. | n.a. | n.a. |
PMID[26938776] |
NPO22258 | Chrysanthemum indicum | Species | Asteraceae | Eukaryota | Flowers | n.a. | n.a. |
PMID[28156114] |
NPO20440 | Chrysanthemum x morifolium | Species | Asteraceae | Eukaryota | Flowers | n.a. | n.a. |
PMID[28248102] |
NPO40901 | Oxytropis chiliophylla | Species | n.a. | n.a. | n.a. | n.a. | n.a. |
PMID[29400468] |
NPO22258 | Chrysanthemum indicum | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[29400471] |
NPO8257 | Carpha glomerata | Species | Cyperaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[30219526] |
NPO22258 | Chrysanthemum indicum | Species | Asteraceae | Eukaryota | Aerial Parts | n.a. | n.a. |
PMID[30726671] |
NPO33288 | Brazilian Red Propolis | Strain | n.a. | n.a. | n.a. | n.a. | n.a. |
PMID[32525315] |
NPO1086 | Botrytis cinerea | Species | Sclerotiniaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[32705864] |
NPO784 | Sinapis alba | Species | Brassicaceae | Eukaryota | Seed | n.a. | n.a. | Database[FooDB] |
NPO19152 | Empetrum nigrum | Species | Ericaceae | Eukaryota | n.a. | n.a. | Database[FooDB] | |
NPO784 | Sinapis alba | Species | Brassicaceae | Eukaryota | n.a. | n.a. | Database[FooDB] | |
NPO784 | Sinapis alba | Species | Brassicaceae | Eukaryota | n.a. | n.a. | Database[FooDB] | |
NPO3344 | Bryonia alba | Species | Cucurbitaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO7845 | Tephrosia elata | Species | Geometridae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO22258 | Chrysanthemum indicum | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO1473 | Xanthorhiza simplicissima | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO6859 | Eurycoma harmandiana | Species | Simaroubaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO784 | Sinapis alba | Species | Brassicaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO2921 | Angelica acutiloba | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO25653 | Spatholobus suberectus | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO19152 | Empetrum nigrum | Species | Ericaceae | Eukaryota | n.a. | n.a. | Database[Phenol-Explorer] | |
NPO19152 | Empetrum nigrum | Species | Ericaceae | Eukaryota | Fruits | n.a. | Database[Phenol-Explorer] | |
NPO20440 | Chrysanthemum x morifolium | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO784 | Sinapis alba | Species | Brassicaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO6859 | Eurycoma harmandiana | Species | Simaroubaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO8790 | Cyanostegia angustifolia | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO3344 | Bryonia alba | Species | Cucurbitaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO22258 | Chrysanthemum indicum | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO373 | Viburnum erubescens | Species | Adoxaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO1473 | Xanthorhiza simplicissima | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO2921 | Angelica acutiloba | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO25628 | Abrus pulchellus | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO2131 | Dactylorhiza viridis | Species | Orchidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO7845 | Tephrosia elata | Species | Geometridae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO25653 | Spatholobus suberectus | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO2921 | Angelica acutiloba | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO7845 | Tephrosia elata | Species | Geometridae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO784 | Sinapis alba | Species | Brassicaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO22258 | Chrysanthemum indicum | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO1473 | Xanthorhiza simplicissima | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO25653 | Spatholobus suberectus | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO22258 | Chrysanthemum indicum | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO25653 | Spatholobus suberectus | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO784 | Sinapis alba | Species | Brassicaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO2921 | Angelica acutiloba | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO20440 | Chrysanthemum x morifolium | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO3151 | Solanum lanceolatum | Species | Solanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO9091 | Orthosiphon spicatus | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO10038.1 | Abies pinsapo var. marocana | Varieties | Pinaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO8938 | Halobacillus litoralis | Species | Bacillaceae | Bacteria | n.a. | n.a. | n.a. | Database[UNPD] |
NPO2921 | Angelica acutiloba | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO26507 | Galenia africana | Species | Aizoaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25149 | Centaurea arguta | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO1473 | Xanthorhiza simplicissima | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25628 | Abrus pulchellus | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO9867 | Ixeris debilis | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO8257 | Carpha glomerata | Species | Cyperaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO3344 | Bryonia alba | Species | Cucurbitaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25653 | Spatholobus suberectus | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO6859 | Eurycoma harmandiana | Species | Simaroubaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25758 | Aspergillus amstelodami | Species | Aspergillaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25533 | Stellaster equestris | Species | Goniasteridae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25730 | Prorhinotermes simplex | Species | Termitoidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25052 | Diphysa robinioides | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO5086 | Alternaria macrospora | Species | Pleosporaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25708 | Erioderma phaeorhizum | Species | Pannariaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO9737 | Ampelocera edentula | Species | Ulmaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO4123 | Trididemnum cyanophorum | Species | Didemnidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO5885 | Bathymodiolus thermophilus | Species | Mytilidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO2765 | Oxytropis falcata | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO1086 | Botrytis cinerea | Species | Sclerotiniaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22258 | Chrysanthemum indicum | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO13474 | Euphrasia genargentea | Species | Orobanchaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO373 | Viburnum erubescens | Species | Adoxaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO9594 | Lysimachia fordiana | Species | Primulaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO7032 | Marasmiellus troyanus | Species | Omphalotaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO593 | Wikstroemia viridiflora | Species | Thymelaeaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO19152 | Empetrum nigrum | Species | Ericaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO4536 | Remirea maritima | Species | Cyperaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO8025 | Aaptos ciliata | Species | Suberitidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO24691 | Astragalus orbiculatus | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21472 | Pterolobium hexapetalum | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO3838 | Chrysosporum ovalisporum | Species | Aphanizomenonaceae | Bacteria | n.a. | n.a. | n.a. | Database[UNPD] |
NPO7845 | Tephrosia elata | Species | Geometridae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO6807 | Ranunculus asiaticus | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO24128 | Cassinia longifolia | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20440 | Chrysanthemum x morifolium | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO24229 | Schoenus nigricans | Species | Cyperaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO5325 | Lobophytum durum | Species | Alcyoniidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO2131 | Dactylorhiza viridis | Species | Orchidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO10132 | Schizophyllum lobatum | Species | Schizophyllaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO2670 | Maytenus chuchuhuasha | Species | Celastraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21669 | Acacia sieberana | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO6065 | Brassica carinata | Species | Brassicaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO8790 | Cyanostegia angustifolia | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO7418 | Eucalyptus resinifera | Species | Myrtaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO9998 | Abies excelsa | Species | Pinaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO4901 | Arnica mollis | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25422 | Artemisia dracunculoides | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO1293 | Streptomyces matensis | Species | Streptomycetaceae | Bacteria | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20812 | Soymida febrifuga | Species | Meliaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO784 | Sinapis alba | Species | Brassicaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO5857 | Achlya heterosexualis | Species | Saprolegniaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO5608 | Croton gratissimus | Species | Euphorbiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO2439 | Diplopterygium glaucum | Species | Gleicheniaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].
Organism ID | NP ID | Organism Material Preparation | Organism Part | NP Quantity (Standard) | NP Quantity (Minimum) | NP Quantity (Maximum) | Quantity Unit | Reference |
---|
☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].
Target ID | Target Type | Target Name | Target Organism | Activity Type | Activity Relation | Value | Unit | Reference |
---|---|---|---|---|---|---|---|---|
NPT83 | Cell Line | MCF7 | Homo sapiens | IC50 | = | 16300.0 | nM | PMID[459920] |
NPT183 | Individual Protein | Arachidonate 5-lipoxygenase | Rattus norvegicus | IC50 | = | 400000.0 | nM | PMID[459921] |
NPT43 | Individual Protein | Tyrosinase | Agaricus bisporus | Inhibition | < | 20.0 | % | PMID[459922] |
NPT461 | Cell Line | PANC-1 | Homo sapiens | CD100 | > | 100.0 | uM | PMID[459924] |
NPT81 | Cell Line | A549 | Homo sapiens | IC50 | = | 41600.0 | nM | PMID[459925] |
NPT165 | Cell Line | HeLa | Homo sapiens | IC50 | = | 23100.0 | nM | PMID[459925] |
NPT453 | Cell Line | HT-1080 | Homo sapiens | IC50 | = | 34000.0 | nM | PMID[459925] |
NPT466 | Cell Line | U-937 | Homo sapiens | IC50 | = | 80200.0 | nM | PMID[459926] |
NPT81 | Cell Line | A549 | Homo sapiens | IC50 | = | 23200.0 | nM | PMID[459927] |
NPT453 | Cell Line | HT-1080 | Homo sapiens | IC50 | = | 17000.0 | nM | PMID[459927] |
NPT461 | Cell Line | PANC-1 | Homo sapiens | PC50 | = | 19.0 | uM | PMID[459927] |
NPT165 | Cell Line | HeLa | Homo sapiens | IC50 | = | 24400.0 | nM | PMID[459927] |
NPT46 | Individual Protein | Thyroid hormone receptor beta-1 | Homo sapiens | Potency | = | 35481.3 | nM | PMID[459928] |
NPT149 | Individual Protein | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Homo sapiens | Potency | = | 25118.9 | nM | PMID[459928] |
NPT48 | Individual Protein | Lysine-specific demethylase 4D-like | Homo sapiens | Potency | = | 35481.3 | nM | PMID[459928] |
NPT50 | Individual Protein | Tyrosyl-DNA phosphodiesterase 1 | Homo sapiens | Potency | = | 39810.7 | nM | PMID[459928] |
NPT51 | Individual Protein | Microtubule-associated protein tau | Homo sapiens | Potency | = | 12589.3 | nM | PMID[459928] |
NPT531 | Individual Protein | Nuclear receptor ROR-gamma | Mus musculus | Potency | = | 35481.3 | nM | PMID[459928] |
NPT51 | Individual Protein | Microtubule-associated protein tau | Homo sapiens | Potency | = | 44668.4 | nM | PMID[459928] |
NPT282 | Individual Protein | MAP kinase ERK2 | Homo sapiens | Potency | = | 31622.8 | nM | PMID[459928] |
NPT151 | Individual Protein | 15-hydroxyprostaglandin dehydrogenase [NAD+] | Homo sapiens | Potency | = | 15848.9 | nM | PMID[459928] |
NPT109 | Individual Protein | Cytochrome P450 3A4 | Homo sapiens | Potency | = | 1584.9 | nM | PMID[459928] |
NPT531 | Individual Protein | Nuclear receptor ROR-gamma | Mus musculus | Potency | = | 2818.4 | nM | PMID[459928] |
NPT81 | Cell Line | A549 | Homo sapiens | IC50 | > | 100000.0 | nM | PMID[459929] |
NPT306 | Cell Line | PC-3 | Homo sapiens | IC50 | > | 100000.0 | nM | PMID[459929] |
NPT170 | Cell Line | SK-MEL-28 | Homo sapiens | IC50 | = | 75000.0 | nM | PMID[459929] |
NPT114 | Cell Line | LoVo | Homo sapiens | IC50 | = | 81000.0 | nM | PMID[459929] |
NPT198 | Individual Protein | Vitamin D receptor | Homo sapiens | Potency | n.a. | 25118.9 | nM | PMID[459928] |
NPT444 | Individual Protein | Ubiquitin carboxyl-terminal hydrolase 1 | Homo sapiens | Potency | n.a. | 56234.1 | nM | PMID[459928] |
NPT520 | Cell Line | 3T3-L1 | Mus musculus | Activity | = | 273.0 | mg/dl | PMID[459931] |
NPT113 | Cell Line | RAW264.7 | Mus musculus | Inhibition | = | 40.1 | % | PMID[459932] |
NPT50 | Individual Protein | Tyrosyl-DNA phosphodiesterase 1 | Homo sapiens | Potency | n.a. | 16360.1 | nM | PMID[459928] |
NPT50 | Individual Protein | Tyrosyl-DNA phosphodiesterase 1 | Homo sapiens | Potency | n.a. | 29092.9 | nM | PMID[459928] |
NPT183 | Individual Protein | Arachidonate 5-lipoxygenase | Rattus norvegicus | IC50 | = | 400000.0 | nM | PMID[459935] |
NPT71 | Cell Line | HEK293 | Homo sapiens | IC50 | = | 109000.0 | nM | PMID[459938] |
NPT83 | Cell Line | MCF7 | Homo sapiens | IC50 | > | 10000.0 | nM | PMID[459940] |
NPT82 | Cell Line | MDA-MB-231 | Homo sapiens | IC50 | > | 10000.0 | nM | PMID[459940] |
NPT1310 | Individual Protein | Xanthine dehydrogenase | Bos taurus | IC50 | = | 107000.0 | nM | PMID[459942] |
NPT306 | Cell Line | PC-3 | Homo sapiens | Activity | = | 66.2 | % | PMID[459943] |
NPT306 | Cell Line | PC-3 | Homo sapiens | Activity | = | 16.6 | % | PMID[459943] |
NPT83 | Cell Line | MCF7 | Homo sapiens | IC50 | > | 50000.0 | nM | PMID[459944] |
NPT306 | Cell Line | PC-3 | Homo sapiens | IC50 | = | 13750.0 | nM | PMID[459944] |
NPT1160 | Cell Line | BJ | Homo sapiens | IC50 | = | 262500.0 | nM | PMID[459944] |
NPT306 | Cell Line | PC-3 | Homo sapiens | Activity | = | 16.3 | % | PMID[459944] |
NPT306 | Cell Line | PC-3 | Homo sapiens | Activity | = | 32.2 | % | PMID[459944] |
NPT306 | Cell Line | PC-3 | Homo sapiens | Activity | = | 10.7 | % | PMID[459944] |
NPT306 | Cell Line | PC-3 | Homo sapiens | Activity | = | 40.8 | % | PMID[459944] |
NPT306 | Cell Line | PC-3 | Homo sapiens | IC50 | = | 8080.0 | nM | PMID[459947] |
NPT2219 | Cell Line | C2C12 | Mus musculus | IC10 | = | 6.14 | ug ml-1 | PMID[459950] |
NPT2219 | Cell Line | C2C12 | Mus musculus | IC50 | = | 32.26 | ug.mL-1 | PMID[459950] |
NPT2 | Others | Unspecified | IC50 | = | 280000.0 | nM | PMID[459921] | |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | Inhibition | = | 5.0 | % | PMID[459921] |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | MIC | = | 6.25 | ug.mL-1 | PMID[459923] |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | IC50 | = | 7400.0 | nM | PMID[459925] |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | IC50 | = | 44300.0 | nM | PMID[459925] |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | IC50 | = | 39500.0 | nM | PMID[459925] |
NPT602 | Organism | Mycobacterium smegmatis | Mycobacterium smegmatis | MIC | = | 468700.0 | nM | PMID[459926] |
NPT602 | Organism | Mycobacterium smegmatis | Mycobacterium smegmatis | MBC | = | 234.3 | uM | PMID[459926] |
NPT88 | Organism | Mycobacterium tuberculosis | Mycobacterium tuberculosis | MIC | = | 195300.0 | nM | PMID[459926] |
NPT88 | Organism | Mycobacterium tuberculosis | Mycobacterium tuberculosis | Inhibition | = | 99.5 | % | PMID[459926] |
NPT88 | Organism | Mycobacterium tuberculosis | Mycobacterium tuberculosis | MBC | = | 416.5 | uM | PMID[459926] |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | IC50 | = | 4710.0 | nM | PMID[459927] |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | IC50 | > | 100000.0 | nM | PMID[459927] |
NPT93 | Individual Protein | Survival motor neuron protein | Homo sapiens | Potency | = | 28183.8 | nM | PMID[459928] |
NPT94 | Individual Protein | Aldehyde dehydrogenase 1A1 | Homo sapiens | Potency | = | 39810.7 | nM | PMID[459928] |
NPT792 | Individual Protein | Arachidonate 15-lipoxygenase | Homo sapiens | Potency | = | 19952.6 | nM | PMID[459928] |
NPT197 | Protein-Protein Interaction | Menin/Histone-lysine N-methyltransferase MLL | Homo sapiens | Potency | = | 35481.3 | nM | PMID[459928] |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | IC50 | > | 100000.0 | nM | PMID[459929] |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | IC50 | = | 49000.0 | nM | PMID[459929] |
NPT888 | Individual Protein | 78 kDa glucose-regulated protein | Homo sapiens | Potency | n.a. | 11220.2 | nM | PMID[459928] |
NPT4304 | Organism | Macrophomina phaseolina | Macrophomina phaseolina | MIC | = | 50.0 | ug.mL-1 | PMID[459933] |
NPT1276 | Organism | Gibberella zeae | Gibberella zeae | MIC | = | 25.0 | ug.mL-1 | PMID[459933] |
NPT3685 | Organism | Fusarium equiseti | Fusarium equiseti | MIC | = | 25.0 | ug.mL-1 | PMID[459933] |
NPT962 | Organism | Alternaria alternata | Alternaria alternata | MIC | = | 25.0 | ug.mL-1 | PMID[459933] |
NPT4635 | Organism | Colletotrichum truncatum | Colletotrichum truncatum | MIC | = | 6.25 | ug.mL-1 | PMID[459933] |
NPT4636 | Organism | Diaporthe longicolla | Diaporthe longicolla | MIC | = | 3.12 | ug.mL-1 | PMID[459933] |
NPT68 | Individual Protein | Aldose reductase | Rattus norvegicus | IC50 | = | 1010.0 | nM | PMID[459934] |
NPT1559 | Protein Family | Cyclooxygenase | Rattus norvegicus | IC50 | = | 400000.0 | nM | PMID[459935] |
NPT2 | Others | Unspecified | Potency | n.a. | 31622.8 | nM | PMID[459928] | |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | IC50 | = | 42000.0 | nM | PMID[459936] |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | IC50 | = | 18000.0 | nM | PMID[459936] |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | IC50 | = | 6300.0 | nM | PMID[459936] |
NPT2 | Others | Unspecified | Ratio CC50/IC50 | = | 1041.7 | n.a. | PMID[459937] | |
NPT27 | Others | Unspecified | CC50 | = | 416700.0 | nM | PMID[459937] | |
NPT634 | Organism | Leishmania amazonensis | Leishmania amazonensis | IC50 | = | 400.0 | nM | PMID[459937] |
NPT634 | Organism | Leishmania amazonensis | Leishmania amazonensis | Ratio IC50 | = | 16.0 | n.a. | PMID[459937] |
NPT115 | Organism | Mycobacterium tuberculosis H37Ra | Mycobacterium tuberculosis H37Ra | MIC>90 | = | 104.0 | uM | PMID[459938] |
NPT115 | Organism | Mycobacterium tuberculosis H37Ra | Mycobacterium tuberculosis H37Ra | IC50 | = | 23800.0 | nM | PMID[459938] |
NPT35 | Others | n.a. | Activity | = | -3.0 | % | PMID[459939] | |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | Activity | = | 3.9 | % | PMID[459939] |
NPT35 | Others | n.a. | Activity | = | 0.38 | mmolequiv/mmol | PMID[459942] | |
NPT35 | Others | n.a. | IC50 | = | 197000.0 | nM | PMID[459942] | |
NPT668 | Individual Protein | P-glycoprotein 1 | Homo sapiens | IC50 | = | 6000.0 | ug.mL-1 | PMID[459945] |
NPT21772 | PROTEIN COMPLEX | GroEL/GroES | Escherichia coli | Inhibition | = | 97.0 | % | PMID[459946] |
NPT21772 | PROTEIN COMPLEX | GroEL/GroES | Escherichia coli | Inhibition | = | 78.0 | % | PMID[459946] |
NPT20555 | ORGANISM | SARS-CoV-2 | Severe acute respiratory syndrome coronavirus 2 | IC50 | > | 20000.0 | nM | PMID[459949] |
NPT20555 | ORGANISM | SARS-CoV-2 | Severe acute respiratory syndrome coronavirus 2 | IC50 | > | 19952.62 | nM | PMID[459949] |
☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.
Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient
●  The left chart: Distribution of similarity level between NPC297186 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).
Similarity Score | Similarity Level | Natural Product ID |
---|---|---|
0.9912 | High Similarity | NPC267552 |
0.9912 | High Similarity | NPC45438 |
0.9912 | High Similarity | NPC115159 |
0.9912 | High Similarity | NPC143427 |
0.9912 | High Similarity | NPC156139 |
0.9912 | High Similarity | NPC73532 |
0.9912 | High Similarity | NPC19174 |
0.9912 | High Similarity | NPC224273 |
0.9826 | High Similarity | NPC32032 |
0.9826 | High Similarity | NPC133909 |
0.9739 | High Similarity | NPC242895 |
0.9658 | High Similarity | NPC13238 |
0.9649 | High Similarity | NPC158222 |
0.9649 | High Similarity | NPC161617 |
0.9565 | High Similarity | NPC159525 |
0.9496 | High Similarity | NPC62952 |
0.9496 | High Similarity | NPC8745 |
0.9417 | High Similarity | NPC169250 |
0.9417 | High Similarity | NPC100067 |
0.9417 | High Similarity | NPC105157 |
0.9417 | High Similarity | NPC98254 |
0.9417 | High Similarity | NPC190043 |
0.9417 | High Similarity | NPC23126 |
0.9417 | High Similarity | NPC72158 |
0.9417 | High Similarity | NPC30501 |
0.9417 | High Similarity | NPC103356 |
0.9417 | High Similarity | NPC162612 |
0.9417 | High Similarity | NPC266689 |
0.9412 | High Similarity | NPC10926 |
0.9402 | High Similarity | NPC196976 |
0.9391 | High Similarity | NPC40649 |
0.9391 | High Similarity | NPC209486 |
0.9339 | High Similarity | NPC221777 |
0.9339 | High Similarity | NPC473017 |
0.9339 | High Similarity | NPC21305 |
0.9333 | High Similarity | NPC267846 |
0.9322 | High Similarity | NPC309765 |
0.931 | High Similarity | NPC188814 |
0.931 | High Similarity | NPC195262 |
0.9262 | High Similarity | NPC102829 |
0.9262 | High Similarity | NPC120488 |
0.9262 | High Similarity | NPC474998 |
0.9256 | High Similarity | NPC116513 |
0.9237 | High Similarity | NPC303737 |
0.9231 | High Similarity | NPC294037 |
0.9211 | High Similarity | NPC276111 |
0.9211 | High Similarity | NPC118288 |
0.9187 | High Similarity | NPC26697 |
0.9153 | High Similarity | NPC146642 |
0.9153 | High Similarity | NPC248363 |
0.9153 | High Similarity | NPC149246 |
0.9113 | High Similarity | NPC34070 |
0.9113 | High Similarity | NPC475042 |
0.9113 | High Similarity | NPC469526 |
0.9106 | High Similarity | NPC92624 |
0.9106 | High Similarity | NPC476119 |
0.9076 | High Similarity | NPC215392 |
0.906 | High Similarity | NPC283844 |
0.906 | High Similarity | NPC241089 |
0.904 | High Similarity | NPC262359 |
0.904 | High Similarity | NPC135801 |
0.904 | High Similarity | NPC64359 |
0.904 | High Similarity | NPC313618 |
0.904 | High Similarity | NPC308037 |
0.9032 | High Similarity | NPC259942 |
0.9032 | High Similarity | NPC233056 |
0.9 | High Similarity | NPC91105 |
0.8974 | High Similarity | NPC121259 |
0.8968 | High Similarity | NPC40524 |
0.8968 | High Similarity | NPC87231 |
0.8968 | High Similarity | NPC205468 |
0.8968 | High Similarity | NPC139074 |
0.8968 | High Similarity | NPC213485 |
0.8968 | High Similarity | NPC257756 |
0.8968 | High Similarity | NPC212631 |
0.8968 | High Similarity | NPC129132 |
0.8952 | High Similarity | NPC109123 |
0.8926 | High Similarity | NPC65761 |
0.8926 | High Similarity | NPC472029 |
0.8917 | High Similarity | NPC226275 |
0.8898 | High Similarity | NPC188646 |
0.8898 | High Similarity | NPC175098 |
0.8898 | High Similarity | NPC242294 |
0.8898 | High Similarity | NPC263670 |
0.8898 | High Similarity | NPC472365 |
0.8898 | High Similarity | NPC312318 |
0.8898 | High Similarity | NPC282780 |
0.8898 | High Similarity | NPC57601 |
0.8898 | High Similarity | NPC337373 |
0.8898 | High Similarity | NPC192304 |
0.8898 | High Similarity | NPC139813 |
0.8898 | High Similarity | NPC166480 |
0.8898 | High Similarity | NPC56031 |
0.8898 | High Similarity | NPC44437 |
0.8889 | High Similarity | NPC175738 |
0.8871 | High Similarity | NPC186098 |
0.8871 | High Similarity | NPC80694 |
0.885 | High Similarity | NPC17525 |
0.8828 | High Similarity | NPC61153 |
0.8828 | High Similarity | NPC130899 |
0.8828 | High Similarity | NPC286336 |
0.8828 | High Similarity | NPC470210 |
0.8828 | High Similarity | NPC283590 |
0.8828 | High Similarity | NPC172262 |
0.8828 | High Similarity | NPC70859 |
0.8814 | High Similarity | NPC230349 |
0.881 | High Similarity | NPC275504 |
0.88 | High Similarity | NPC60558 |
0.878 | High Similarity | NPC475733 |
0.878 | High Similarity | NPC477454 |
0.8761 | High Similarity | NPC141523 |
0.876 | High Similarity | NPC264112 |
0.876 | High Similarity | NPC239495 |
0.876 | High Similarity | NPC65005 |
0.876 | High Similarity | NPC234560 |
0.876 | High Similarity | NPC194764 |
0.876 | High Similarity | NPC9985 |
0.876 | High Similarity | NPC39426 |
0.876 | High Similarity | NPC131039 |
0.875 | High Similarity | NPC28753 |
0.875 | High Similarity | NPC159623 |
0.875 | High Similarity | NPC144051 |
0.875 | High Similarity | NPC20560 |
0.875 | High Similarity | NPC50898 |
0.875 | High Similarity | NPC274121 |
0.875 | High Similarity | NPC204960 |
0.875 | High Similarity | NPC78540 |
0.875 | High Similarity | NPC82225 |
0.875 | High Similarity | NPC294593 |
0.875 | High Similarity | NPC18877 |
0.875 | High Similarity | NPC213216 |
0.873 | High Similarity | NPC244441 |
0.873 | High Similarity | NPC147757 |
0.873 | High Similarity | NPC185497 |
0.873 | High Similarity | NPC247779 |
0.872 | High Similarity | NPC179898 |
0.871 | High Similarity | NPC473691 |
0.871 | High Similarity | NPC95309 |
0.8696 | High Similarity | NPC116842 |
0.8692 | High Similarity | NPC235428 |
0.8692 | High Similarity | NPC150399 |
0.8692 | High Similarity | NPC1486 |
0.8692 | High Similarity | NPC44960 |
0.8692 | High Similarity | NPC186838 |
0.8692 | High Similarity | NPC472364 |
0.8692 | High Similarity | NPC240593 |
0.8692 | High Similarity | NPC53206 |
0.8692 | High Similarity | NPC290030 |
0.8692 | High Similarity | NPC168105 |
0.8692 | High Similarity | NPC476333 |
0.8692 | High Similarity | NPC66349 |
0.8692 | High Similarity | NPC474110 |
0.8692 | High Similarity | NPC213603 |
0.8692 | High Similarity | NPC98115 |
0.8692 | High Similarity | NPC477243 |
0.8692 | High Similarity | NPC25287 |
0.8692 | High Similarity | NPC477244 |
0.8692 | High Similarity | NPC477242 |
0.8692 | High Similarity | NPC274109 |
0.8692 | High Similarity | NPC41461 |
0.8692 | High Similarity | NPC53414 |
0.8692 | High Similarity | NPC87545 |
0.8692 | High Similarity | NPC249606 |
0.8692 | High Similarity | NPC472367 |
0.8692 | High Similarity | NPC473391 |
0.8692 | High Similarity | NPC12165 |
0.8684 | High Similarity | NPC224584 |
0.8678 | High Similarity | NPC229649 |
0.8672 | High Similarity | NPC267205 |
0.8661 | High Similarity | NPC198249 |
0.864 | High Similarity | NPC305518 |
0.864 | High Similarity | NPC128428 |
0.864 | High Similarity | NPC107672 |
0.8632 | High Similarity | NPC223004 |
0.8629 | High Similarity | NPC201728 |
0.8629 | High Similarity | NPC262671 |
0.8626 | High Similarity | NPC472419 |
0.8626 | High Similarity | NPC116632 |
0.8626 | High Similarity | NPC250266 |
0.8626 | High Similarity | NPC209560 |
0.8626 | High Similarity | NPC294409 |
0.8626 | High Similarity | NPC181124 |
0.8626 | High Similarity | NPC317119 |
0.8626 | High Similarity | NPC266597 |
0.8626 | High Similarity | NPC7013 |
0.8626 | High Similarity | NPC290291 |
0.8626 | High Similarity | NPC153979 |
0.8626 | High Similarity | NPC84585 |
0.8626 | High Similarity | NPC228661 |
0.8626 | High Similarity | NPC254841 |
0.8626 | High Similarity | NPC175552 |
0.8626 | High Similarity | NPC212767 |
0.8626 | High Similarity | NPC162680 |
0.8626 | High Similarity | NPC303644 |
0.8626 | High Similarity | NPC188879 |
0.8626 | High Similarity | NPC476480 |
0.8626 | High Similarity | NPC299379 |
0.8626 | High Similarity | NPC275055 |
0.8621 | High Similarity | NPC268388 |
0.8621 | High Similarity | NPC114682 |
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.
●  The left chart: Distribution of similarity level between NPC297186 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).
Similarity Score | Similarity Level | Drug ID | Developmental Stage |
---|---|---|---|
0.904 | High Similarity | NPD943 | Approved |
0.904 | High Similarity | NPD1240 | Approved |
0.8898 | High Similarity | NPD1607 | Approved |
0.876 | High Similarity | NPD1510 | Phase 2 |
0.8615 | High Similarity | NPD1509 | Clinical (unspecified phase) |
0.8561 | High Similarity | NPD1549 | Phase 2 |
0.8485 | Intermediate Similarity | NPD1550 | Clinical (unspecified phase) |
0.8485 | Intermediate Similarity | NPD1552 | Clinical (unspecified phase) |
0.8362 | Intermediate Similarity | NPD9266 | Approved |
0.8362 | Intermediate Similarity | NPD74 | Approved |
0.8333 | Intermediate Similarity | NPD1164 | Approved |
0.8333 | Intermediate Similarity | NPD651 | Clinical (unspecified phase) |
0.8306 | Intermediate Similarity | NPD1201 | Approved |
0.8276 | Intermediate Similarity | NPD9263 | Approved |
0.8276 | Intermediate Similarity | NPD9264 | Approved |
0.8276 | Intermediate Similarity | NPD9267 | Approved |
0.8276 | Intermediate Similarity | NPD9265 | Clinical (unspecified phase) |
0.8189 | Intermediate Similarity | NPD1470 | Approved |
0.8116 | Intermediate Similarity | NPD1511 | Approved |
0.8115 | Intermediate Similarity | NPD9493 | Approved |
0.8115 | Intermediate Similarity | NPD405 | Clinical (unspecified phase) |
0.8058 | Intermediate Similarity | NPD7410 | Clinical (unspecified phase) |
0.8058 | Intermediate Similarity | NPD4378 | Clinical (unspecified phase) |
0.8 | Intermediate Similarity | NPD1512 | Approved |
0.8 | Intermediate Similarity | NPD2796 | Approved |
0.7986 | Intermediate Similarity | NPD7390 | Discontinued |
0.7931 | Intermediate Similarity | NPD9261 | Approved |
0.7907 | Intermediate Similarity | NPD1203 | Approved |
0.7902 | Intermediate Similarity | NPD4380 | Phase 2 |
0.7883 | Intermediate Similarity | NPD970 | Clinical (unspecified phase) |
0.7868 | Intermediate Similarity | NPD1551 | Phase 2 |
0.7857 | Intermediate Similarity | NPD6799 | Approved |
0.7845 | Intermediate Similarity | NPD846 | Approved |
0.7845 | Intermediate Similarity | NPD940 | Approved |
0.784 | Intermediate Similarity | NPD9545 | Approved |
0.7812 | Intermediate Similarity | NPD9269 | Phase 2 |
0.7805 | Intermediate Similarity | NPD9281 | Approved |
0.7778 | Intermediate Similarity | NPD9268 | Approved |
0.7778 | Intermediate Similarity | NPD4196 | Clinical (unspecified phase) |
0.777 | Intermediate Similarity | NPD3750 | Approved |
0.7759 | Intermediate Similarity | NPD1242 | Phase 1 |
0.7737 | Intermediate Similarity | NPD5405 | Approved |
0.7737 | Intermediate Similarity | NPD5406 | Approved |
0.7737 | Intermediate Similarity | NPD5408 | Approved |
0.7737 | Intermediate Similarity | NPD5404 | Approved |
0.7724 | Intermediate Similarity | NPD7411 | Suspended |
0.7681 | Intermediate Similarity | NPD2344 | Approved |
0.7671 | Intermediate Similarity | NPD1934 | Approved |
0.7643 | Intermediate Similarity | NPD1878 | Clinical (unspecified phase) |
0.7635 | Intermediate Similarity | NPD3882 | Suspended |
0.7619 | Intermediate Similarity | NPD2801 | Approved |
0.7619 | Intermediate Similarity | NPD2393 | Clinical (unspecified phase) |
0.7609 | Intermediate Similarity | NPD2935 | Discontinued |
0.7584 | Intermediate Similarity | NPD4381 | Clinical (unspecified phase) |
0.7584 | Intermediate Similarity | NPD3749 | Approved |
0.7584 | Intermediate Similarity | NPD7075 | Discontinued |
0.7571 | Intermediate Similarity | NPD1243 | Approved |
0.7568 | Intermediate Similarity | NPD8443 | Clinical (unspecified phase) |
0.7538 | Intermediate Similarity | NPD9717 | Approved |
0.7534 | Intermediate Similarity | NPD6599 | Discontinued |
0.7518 | Intermediate Similarity | NPD6651 | Approved |
0.75 | Intermediate Similarity | NPD7096 | Clinical (unspecified phase) |
0.75 | Intermediate Similarity | NPD7819 | Suspended |
0.7481 | Intermediate Similarity | NPD6859 | Clinical (unspecified phase) |
0.7465 | Intermediate Similarity | NPD2309 | Approved |
0.7462 | Intermediate Similarity | NPD1547 | Clinical (unspecified phase) |
0.7447 | Intermediate Similarity | NPD2800 | Approved |
0.7445 | Intermediate Similarity | NPD230 | Phase 1 |
0.7444 | Intermediate Similarity | NPD2798 | Approved |
0.7432 | Intermediate Similarity | NPD6801 | Discontinued |
0.7417 | Intermediate Similarity | NPD1237 | Approved |
0.7413 | Intermediate Similarity | NPD643 | Clinical (unspecified phase) |
0.741 | Intermediate Similarity | NPD3748 | Approved |
0.7353 | Intermediate Similarity | NPD3764 | Approved |
0.7329 | Intermediate Similarity | NPD5403 | Approved |
0.7328 | Intermediate Similarity | NPD422 | Phase 1 |
0.7328 | Intermediate Similarity | NPD2934 | Approved |
0.7328 | Intermediate Similarity | NPD2933 | Approved |
0.7324 | Intermediate Similarity | NPD7421 | Clinical (unspecified phase) |
0.731 | Intermediate Similarity | NPD5401 | Approved |
0.731 | Intermediate Similarity | NPD642 | Clinical (unspecified phase) |
0.7299 | Intermediate Similarity | NPD520 | Approved |
0.729 | Intermediate Similarity | NPD7852 | Clinical (unspecified phase) |
0.7287 | Intermediate Similarity | NPD1548 | Phase 1 |
0.7286 | Intermediate Similarity | NPD2799 | Discontinued |
0.7285 | Intermediate Similarity | NPD7768 | Phase 2 |
0.7273 | Intermediate Similarity | NPD3972 | Approved |
0.7265 | Intermediate Similarity | NPD2859 | Approved |
0.7265 | Intermediate Similarity | NPD2860 | Approved |
0.7226 | Intermediate Similarity | NPD2313 | Discontinued |
0.7219 | Intermediate Similarity | NPD3817 | Phase 2 |
0.7211 | Intermediate Similarity | NPD920 | Approved |
0.7206 | Intermediate Similarity | NPD6832 | Phase 2 |
0.7203 | Intermediate Similarity | NPD2654 | Approved |
0.7197 | Intermediate Similarity | NPD3818 | Discontinued |
0.7179 | Intermediate Similarity | NPD6166 | Phase 2 |
0.7179 | Intermediate Similarity | NPD6167 | Clinical (unspecified phase) |
0.7179 | Intermediate Similarity | NPD6168 | Clinical (unspecified phase) |
0.7161 | Intermediate Similarity | NPD6232 | Discontinued |
0.7134 | Intermediate Similarity | NPD7473 | Discontinued |
0.712 | Intermediate Similarity | NPD4750 | Phase 3 |
0.7097 | Intermediate Similarity | NPD6959 | Discontinued |
0.7083 | Intermediate Similarity | NPD3020 | Approved |
0.7075 | Intermediate Similarity | NPD2534 | Approved |
0.7075 | Intermediate Similarity | NPD2533 | Approved |
0.7075 | Intermediate Similarity | NPD2532 | Approved |
0.7068 | Intermediate Similarity | NPD1610 | Phase 2 |
0.7063 | Intermediate Similarity | NPD5953 | Discontinued |
0.7059 | Intermediate Similarity | NPD4868 | Clinical (unspecified phase) |
0.7044 | Intermediate Similarity | NPD7286 | Phase 2 |
0.7044 | Intermediate Similarity | NPD6020 | Phase 2 |
0.7044 | Intermediate Similarity | NPD7054 | Approved |
0.7044 | Intermediate Similarity | NPD7804 | Clinical (unspecified phase) |
0.7034 | Intermediate Similarity | NPD1196 | Approved |
0.7031 | Intermediate Similarity | NPD1241 | Discontinued |
0.7007 | Intermediate Similarity | NPD1543 | Discontinued |
0.7 | Intermediate Similarity | NPD7074 | Phase 3 |
0.7 | Intermediate Similarity | NPD7472 | Approved |
0.6993 | Remote Similarity | NPD6100 | Approved |
0.6993 | Remote Similarity | NPD6099 | Approved |
0.6993 | Remote Similarity | NPD5402 | Approved |
0.6985 | Remote Similarity | NPD2797 | Approved |
0.6983 | Remote Similarity | NPD9256 | Approved |
0.6983 | Remote Similarity | NPD9258 | Approved |
0.6978 | Remote Similarity | NPD411 | Approved |
0.6978 | Remote Similarity | NPD3268 | Approved |
0.6966 | Remote Similarity | NPD1195 | Approved |
0.6957 | Remote Similarity | NPD6797 | Phase 2 |
0.695 | Remote Similarity | NPD447 | Suspended |
0.6949 | Remote Similarity | NPD1202 | Approved |
0.6939 | Remote Similarity | NPD3300 | Phase 2 |
0.6928 | Remote Similarity | NPD1465 | Phase 2 |
0.6923 | Remote Similarity | NPD4308 | Phase 3 |
0.6923 | Remote Similarity | NPD5494 | Approved |
0.6918 | Remote Similarity | NPD4628 | Phase 3 |
0.6917 | Remote Similarity | NPD2932 | Approved |
0.6917 | Remote Similarity | NPD3019 | Approved |
0.6914 | Remote Similarity | NPD7251 | Discontinued |
0.6912 | Remote Similarity | NPD3225 | Approved |
0.6912 | Remote Similarity | NPD1876 | Approved |
0.6894 | Remote Similarity | NPD1759 | Phase 1 |
0.6889 | Remote Similarity | NPD1608 | Approved |
0.6889 | Remote Similarity | NPD1481 | Phase 2 |
0.6887 | Remote Similarity | NPD3226 | Approved |
0.6884 | Remote Similarity | NPD9494 | Approved |
0.6883 | Remote Similarity | NPD2296 | Approved |
0.6871 | Remote Similarity | NPD7808 | Phase 3 |
0.6871 | Remote Similarity | NPD4419 | Clinical (unspecified phase) |
0.6871 | Remote Similarity | NPD4338 | Clinical (unspecified phase) |
0.6867 | Remote Similarity | NPD6980 | Clinical (unspecified phase) |
0.6859 | Remote Similarity | NPD919 | Approved |
0.6857 | Remote Similarity | NPD1296 | Phase 2 |
0.6846 | Remote Similarity | NPD7422 | Clinical (unspecified phase) |
0.6842 | Remote Similarity | NPD111 | Approved |
0.6831 | Remote Similarity | NPD1933 | Approved |
0.6831 | Remote Similarity | NPD1899 | Clinical (unspecified phase) |
0.6828 | Remote Similarity | NPD2346 | Discontinued |
0.6818 | Remote Similarity | NPD1758 | Phase 1 |
0.6815 | Remote Similarity | NPD1535 | Discovery |
0.6812 | Remote Similarity | NPD1019 | Discontinued |
0.681 | Remote Similarity | NPD6559 | Discontinued |
0.6794 | Remote Similarity | NPD256 | Approved |
0.6794 | Remote Similarity | NPD255 | Approved |
0.6792 | Remote Similarity | NPD3926 | Phase 2 |
0.679 | Remote Similarity | NPD1729 | Discontinued |
0.6774 | Remote Similarity | NPD1929 | Approved |
0.6774 | Remote Similarity | NPD1930 | Approved |
0.6774 | Remote Similarity | NPD4288 | Approved |
0.6774 | Remote Similarity | NPD1931 | Clinical (unspecified phase) |
0.6772 | Remote Similarity | NPD1247 | Approved |
0.6757 | Remote Similarity | NPD6190 | Approved |
0.675 | Remote Similarity | NPD1432 | Clinical (unspecified phase) |
0.6742 | Remote Similarity | NPD9568 | Approved |
0.6739 | Remote Similarity | NPD3267 | Approved |
0.6739 | Remote Similarity | NPD3266 | Approved |
0.6736 | Remote Similarity | NPD9279 | Approved |
0.6726 | Remote Similarity | NPD9089 | Approved |
0.6715 | Remote Similarity | NPD1755 | Approved |
0.6714 | Remote Similarity | NPD4908 | Phase 1 |
0.6714 | Remote Similarity | NPD1529 | Clinical (unspecified phase) |
0.6712 | Remote Similarity | NPD1471 | Phase 3 |
0.6694 | Remote Similarity | NPD1809 | Phase 2 |
0.6694 | Remote Similarity | NPD844 | Approved |
0.669 | Remote Similarity | NPD7033 | Discontinued |
0.669 | Remote Similarity | NPD3299 | Clinical (unspecified phase) |
0.6689 | Remote Similarity | NPD6398 | Clinical (unspecified phase) |
0.6689 | Remote Similarity | NPD3400 | Discontinued |
0.6689 | Remote Similarity | NPD7003 | Approved |
0.6667 | Remote Similarity | NPD845 | Approved |
0.6667 | Remote Similarity | NPD1238 | Approved |
0.6667 | Remote Similarity | NPD17 | Approved |
0.6667 | Remote Similarity | NPD7458 | Discontinued |
0.6646 | Remote Similarity | NPD7993 | Clinical (unspecified phase) |
0.6644 | Remote Similarity | NPD2354 | Approved |
0.6643 | Remote Similarity | NPD4307 | Phase 2 |
0.6643 | Remote Similarity | NPD1530 | Clinical (unspecified phase) |
0.6642 | Remote Similarity | NPD4878 | Approved |
0.6642 | Remote Similarity | NPD1894 | Discontinued |
0.6641 | Remote Similarity | NPD6831 | Clinical (unspecified phase) |
0.6639 | Remote Similarity | NPD288 | Approved |
Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.
Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.