Molecular Weight:   | 222.09 |
Volume:   | 223.61 |
LogP:   | 2.501 |
LogD:   | 2.682 |
LogS:   | -2.884 |
# Rotatable Bonds:   | 4 |
TPSA:   | 36.92 |
# H-Bond Aceptor:   | 4 |
# H-Bond Donor:   | 0 |
# Rings:   | 2 |
# Heavy Atoms:   | 4 |
QED Drug-Likeness Score:   | 0.731 |
Synthetic Accessibility Score:   | 2.493 |
Fsp3:   | 0.333 |
Lipinski Rule-of-5:   | Accepted |
Pfizer Rule:   | Accepted |
GSK Rule:   | Accepted |
BMS Rule:   | 0 |
Golden Triangle Rule:   | Accepted |
Chelating Alert:   | 0 |
PAINS Alert:   | 0 |
Caco-2 Permeability:   | -4.486 |
MDCK Permeability:   | 2.4364493583561853e-05 |
Pgp-inhibitor:   | 0.02 |
Pgp-substrate:   | 0.0 |
Human Intestinal Absorption (HIA):   | 0.002 |
20% Bioavailability (F20%):   | 0.007 |
30% Bioavailability (F30%):   | 0.016 |
Blood-Brain-Barrier Penetration (BBB):   | 0.307 |
Plasma Protein Binding (PPB):   | 90.16094207763672% |
Volume Distribution (VD):   | 0.972 |
Pgp-substrate:   | 4.841390609741211% |
CYP1A2-inhibitor:   | 0.972 |
CYP1A2-substrate:   | 0.905 |
CYP2C19-inhibitor:   | 0.915 |
CYP2C19-substrate:   | 0.857 |
CYP2C9-inhibitor:   | 0.107 |
CYP2C9-substrate:   | 0.906 |
CYP2D6-inhibitor:   | 0.908 |
CYP2D6-substrate:   | 0.915 |
CYP3A4-inhibitor:   | 0.906 |
CYP3A4-substrate:   | 0.476 |
Clearance (CL):   | 10.23 |
Half-life (T1/2):   | 0.502 |
hERG Blockers:   | 0.038 |
Human Hepatotoxicity (H-HT):   | 0.04 |
Drug-inuced Liver Injury (DILI):   | 0.029 |
AMES Toxicity:   | 0.037 |
Rat Oral Acute Toxicity:   | 0.028 |
Maximum Recommended Daily Dose:   | 0.057 |
Skin Sensitization:   | 0.91 |
Carcinogencity:   | 0.946 |
Eye Corrosion:   | 0.076 |
Eye Irritation:   | 0.866 |
Respiratory Toxicity:   | 0.191 |
Natural Product ID:   | NPC283170 |
Common Name*:   | Dillapiole |
IUPAC Name:   | 4,5-dimethoxy-6-prop-2-enyl-1,3-benzodioxole |
Synonyms:   | Dillapiol |
Standard InCHIKey:   | LIKYNOPXHGPMIH-UHFFFAOYSA-N |
Standard InCHI:   | InChI=1S/C12H14O4/c1-4-5-8-6-9-11(16-7-15-9)12(14-3)10(8)13-2/h4,6H,1,5,7H2,2-3H3 |
SMILES:   | C=CCc1cc2c(c(c1OC)OC)OCO2 |
Synthetic Gene Cluster:   | n.a. |
ChEMBL Identifier:   | CHEMBL470874 |
PubChem CID:   |
10231 |
Chemical Classification**:   |
|
*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.
Organism ID | Organism Name | Taxonomy Level | Family | SuperKingdom | Isolation Part | Collection Location | Collection Time | Reference |
---|---|---|---|---|---|---|---|---|
NPO14948 | Brucea javanica | Species | Simaroubaceae | Eukaryota | n.a. | seed | n.a. | DOI[10.1016/0031-9422(96)00258-0] |
NPO28295 | Foeniculum vulgare | Species | Apiaceae | Eukaryota | n.a. | leaf | n.a. | DOI[10.1016/S0031-9422(00)94055-X] |
NPO22104 | Trifolium pratense | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | DOI[10.1016/S0031-9422(00)94679-X] |
NPO28928 | Piper nigrum | Species | Piperaceae | Eukaryota | n.a. | fruit | n.a. | DOI[10.1016/S0040-4039(01)00209-X] |
NPO14948 | Brucea javanica | Species | Simaroubaceae | Eukaryota | n.a. | fruit | n.a. | DOI[10.1016/S1383-5769(99)00023-9] |
NPO21079 | Actinomadura hibisca | Species | Thermomonosporaceae | Bacteria | n.a. | n.a. | n.a. | DOI[10.1021/jo00272a013] |
NPO28295 | Foeniculum vulgare | Species | Apiaceae | Eukaryota | n.a. | flower | n.a. | DOI[10.3390/70200245] |
NPO14948 | Brucea javanica | Species | Simaroubaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[10086989] |
NPO28928 | Piper nigrum | Species | Piperaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[10575373] |
NPO21587 | Hypericum papuanum | Species | Hypericaceae | Eukaryota | aerial parts | n.a. | n.a. |
PMID[10650088] |
NPO20889 | Anastrepha suspensa | Species | Tephritidae | Eukaryota | n.a. | n.a. | n.a. |
PMID[10706642] |
NPO6473.1 | Perilla frutescens var. acuta | Strain | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[10757731] |
NPO20635 | Dalbergia frutescens | Species | Fabaceae | Eukaryota | bark | n.a. | n.a. |
PMID[11076565] |
NPO21587 | Hypericum papuanum | Species | Hypericaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[11421727] |
NPO18141 | Solanum torvum | Species | Solanaceae | Eukaryota | n.a. | fruit | n.a. |
PMID[11830167] |
NPO21334 | Artemisia dracunculus | Species | Asteraceae | Eukaryota | leaves | n.a. | n.a. |
PMID[14738379] |
NPO21334 | Artemisia dracunculus | Species | Asteraceae | Eukaryota | underground organs | n.a. | n.a. |
PMID[14738379] |
NPO21334 | Artemisia dracunculus | Species | Asteraceae | Eukaryota | dried aerial organs | n.a. | n.a. |
PMID[14738379] |
NPO21334 | Artemisia dracunculus | Species | Asteraceae | Eukaryota | roots and stolons | n.a. | n.a. |
PMID[14738379] |
NPO21334 | Artemisia dracunculus | Species | Asteraceae | Eukaryota | dried aerial organs | n.a. | n.a. |
PMID[14738379] |
NPO14948 | Brucea javanica | Species | Simaroubaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[1512598] |
NPO14948 | Brucea javanica | Species | Simaroubaceae | Eukaryota | Seeds | n.a. | n.a. |
PMID[15165151] |
NPO28928 | Piper nigrum | Species | Piperaceae | Eukaryota | n.a. | leaf | n.a. |
PMID[15467205] |
NPO15520 | Dracocephalum kotschyi | Species | Lamiaceae | Eukaryota | n.a. | leaf | n.a. |
PMID[15949825] |
NPO13968 | Garcinia scortechinii | Species | Clusiaceae | Eukaryota | fruits | n.a. | n.a. |
PMID[16038540] |
NPO14358 | Rhodobacter sphaeroides | Species | Rhodobacteraceae | Bacteria | n.a. | n.a. | n.a. |
PMID[1612412] |
NPO21023 | Astilbe koreana | Species | Saxifragaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[16580200] |
NPO28928 | Piper nigrum | Species | Piperaceae | Eukaryota | n.a. | whole plant | n.a. |
PMID[16808005] |
NPO14948 | Brucea javanica | Species | Simaroubaceae | Eukaryota | fruit | Indonesia | n.a. |
PMID[17896817] |
NPO8068 | Blumea mollis | Species | Asteraceae | Eukaryota | n.a. | leaf | n.a. |
PMID[18566831] |
NPO15146 | Myrica nana | Species | Myricaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[18723353] |
NPO14948 | Brucea javanica | Species | Simaroubaceae | Eukaryota | n.a. | Vietnam | n.a. |
PMID[19026551] |
NPO14162 | Chlorophytum borivilianum | Species | Asparagaceae | Eukaryota | roots | n.a. | n.a. |
PMID[19128156] |
NPO7016 | Gardenia tubifera | Species | Rubiaceae | Eukaryota | exudate | n.a. | n.a. |
PMID[20028108] |
NPO14948 | Brucea javanica | Species | Simaroubaceae | Eukaryota | seeds | n.a. | n.a. |
PMID[20050684] |
NPO12357 | Lycopus europaeus | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[20674349] |
NPO21460 | Anethum graveolens | Species | Apiaceae | Eukaryota | n.a. | seed | n.a. |
PMID[21049975] |
NPO21079 | Actinomadura hibisca | Species | Thermomonosporaceae | Bacteria | n.a. | n.a. | n.a. |
PMID[21119678] |
NPO11492 | Kopsia grandifolia | Species | Apocynaceae | Eukaryota | n.a. | leaf | n.a. |
PMID[21428274] |
NPO11492 | Kopsia grandifolia | Species | Apocynaceae | Eukaryota | n.a. | stem | n.a. |
PMID[21428274] |
NPO21470 | Conoideocrella tenuis | Species | Clavicipitaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[21473608] |
NPO21470 | Conoideocrella tenuis | Species | Clavicipitaceae | Eukaryota | n.a. | mycelium | n.a. |
PMID[21473608] |
NPO8650 | Perilla frutescens | Species | Lamiaceae | Eukaryota | leaves | n.a. | n.a. |
PMID[22272932] |
NPO14948 | Brucea javanica | Species | Simaroubaceae | Eukaryota | Seeds | n.a. | n.a. |
PMID[22506620] |
NPO28928 | Piper nigrum | Species | Piperaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[23102654] |
NPO14621 | Cuminum cyminum | Species | Apiaceae | Eukaryota | n.a. | seed | n.a. |
PMID[23507295] |
NPO28295 | Foeniculum vulgare | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[24617303] |
NPO21460 | Anethum graveolens | Species | Apiaceae | Eukaryota | n.a. | aerial part | n.a. |
PMID[25154406] |
NPO8650 | Perilla frutescens | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[25320841] |
NPO13106 | Rhodomyrtus tomentosa | Species | Myrtaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[25466012] |
NPO1795 | Fragaria vesca | Species | Rosaceae | Eukaryota | n.a. | fruit | n.a. |
PMID[26169681] |
NPO18951 | Ligusticum sinense | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[26521454] |
NPO15520 | Dracocephalum kotschyi | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[26522747] |
NPO13106 | Rhodomyrtus tomentosa | Species | Myrtaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[28245113] |
NPO22104 | Trifolium pratense | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[30199256] |
NPO28928 | Piper nigrum | Species | Piperaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[31103896] |
NPO21334 | Artemisia dracunculus | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[31815461] |
NPO20045 | Burkholderia cepacia | Species | Burkholderiaceae | Bacteria | n.a. | n.a. | n.a. |
PMID[3839140] |
NPO14948 | Brucea javanica | Species | Simaroubaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[6481366] |
NPO14948 | Brucea javanica | Species | Simaroubaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[7561896] |
NPO20045 | Burkholderia cepacia | Species | Burkholderiaceae | Bacteria | n.a. | n.a. | n.a. |
PMID[7684040] |
NPO24658 | Dillenia papuana | Species | Dilleniaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[7798959] |
NPO8059 | Piper aduncum | Species | Piperaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[8158163] |
NPO211 | Aplysina cauliformis | Species | Aplysinidae | Eukaryota | n.a. | n.a. | n.a. |
PMID[8350091] |
NPO14621 | Cuminum cyminum | Species | Apiaceae | Eukaryota | Seed | n.a. | n.a. | Database[FooDB] |
NPO21460 | Anethum graveolens | Species | Apiaceae | Eukaryota | Seed | n.a. | n.a. | Database[FooDB] |
NPO21334 | Artemisia dracunculus | Species | Asteraceae | Eukaryota | Shoot | n.a. | n.a. | Database[FooDB] |
NPO14621 | Cuminum cyminum | Species | Apiaceae | Eukaryota | n.a. | n.a. | Database[FooDB] | |
NPO21334 | Artemisia dracunculus | Species | Asteraceae | Eukaryota | n.a. | n.a. | Database[FooDB] | |
NPO14621 | Cuminum cyminum | Species | Apiaceae | Eukaryota | n.a. | n.a. | Database[FooDB] | |
NPO21460 | Anethum graveolens | Species | Apiaceae | Eukaryota | n.a. | n.a. | Database[FooDB] | |
NPO21460 | Anethum graveolens | Species | Apiaceae | Eukaryota | n.a. | n.a. | Database[FooDB] | |
NPO28928 | Piper nigrum | Species | Piperaceae | Eukaryota | n.a. | n.a. | Database[FooDB] | |
NPO28928 | Piper nigrum | Species | Piperaceae | Eukaryota | n.a. | n.a. | Database[FooDB] | |
NPO28928 | Piper nigrum | Species | Piperaceae | Eukaryota | Fruit | n.a. | n.a. | Database[FooDB] |
NPO21334 | Artemisia dracunculus | Species | Asteraceae | Eukaryota | Leaf | n.a. | n.a. | Database[FooDB] |
NPO21460 | Anethum graveolens | Species | Apiaceae | Eukaryota | Leaf | n.a. | n.a. | Database[FooDB] |
NPO21334 | Artemisia dracunculus | Species | Asteraceae | Eukaryota | Plant | n.a. | n.a. | Database[FooDB] |
NPO21460 | Anethum graveolens | Species | Apiaceae | Eukaryota | Plant | n.a. | n.a. | Database[FooDB] |
NPO21460 | Anethum graveolens | Species | Apiaceae | Eukaryota | Root | n.a. | n.a. | Database[FooDB] |
NPO21334 | Artemisia dracunculus | Species | Asteraceae | Eukaryota | Seed | n.a. | n.a. | Database[FooDB] |
NPO20610 | Mosla dianthera | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO14948 | Brucea javanica | Species | Simaroubaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO25276 | Ligusticum scoticum | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO30338 | Piper nove | Species | Piperaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO31073 | Ligusticum chuanxiong | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO18141 | Solanum torvum | Species | Solanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO19953 | Lupinus formosus | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO21460 | Anethum graveolens | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO31071 | Erigeron sp | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO1795 | Fragaria vesca | Species | Rosaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO22104 | Trifolium pratense | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO19714 | Orthodon formosanus | Species | Cyprinidae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO18951 | Ligusticum sinense | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO14621 | Cuminum cyminum | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO8650 | Perilla frutescens | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO22622 | Coptis deltoidea | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO28928 | Piper nigrum | Species | Piperaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO28295 | Foeniculum vulgare | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO21334 | Artemisia dracunculus | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO8059 | Piper aduncum | Species | Piperaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO12357 | Lycopus europaeus | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO13014 | Ipomoea cairica | Species | Convolvulaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO13106 | Rhodomyrtus tomentosa | Species | Myrtaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO15520 | Dracocephalum kotschyi | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO6473.1 | Perilla frutescens var. acuta | Strain | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO14621 | Cuminum cyminum | Species | Apiaceae | Eukaryota | n.a. | n.a. | Database[Phenol-Explorer] | |
NPO21460 | Anethum graveolens | Species | Apiaceae | Eukaryota | n.a. | n.a. | Database[Phenol-Explorer] | |
NPO20508 | Ilex kaushue | Species | Aquifoliaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO21334 | Artemisia dracunculus | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO4785 | Persicaria thunbergii | Species | Polygonaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO3465 | Aconitum leucostomum | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO18951 | Ligusticum sinense | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO18141 | Solanum torvum | Species | Solanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO13014 | Ipomoea cairica | Species | Convolvulaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO21587 | Hypericum papuanum | Species | Hypericaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO1795 | Fragaria vesca | Species | Rosaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO25276 | Ligusticum scoticum | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO28295 | Foeniculum vulgare | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO25338 | Piper nove-hollandae | Species | Piperaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO8650 | Perilla frutescens | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO12357 | Lycopus europaeus | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO13106 | Rhodomyrtus tomentosa | Species | Myrtaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO21460 | Anethum graveolens | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO14948 | Brucea javanica | Species | Simaroubaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO8059 | Piper aduncum | Species | Piperaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO15520 | Dracocephalum kotschyi | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO22622 | Coptis deltoidea | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO4004 | Aquilegia ecalcarata | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO6473.1 | Perilla frutescens var. acuta | Strain | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO16703 | Isodon lophanthoides | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO6575 | Erigeron sp. | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO20134 | Dicliptera riparia | Species | Acanthaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO12089 | Trifolium alexandrinum | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO19714 | Orthodon formosanus | Species | Cyprinidae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO13968 | Garcinia scortechinii | Species | Clusiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO14621 | Cuminum cyminum | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO19953 | Lupinus formosus | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO22104 | Trifolium pratense | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO28928 | Piper nigrum | Species | Piperaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO20610 | Mosla dianthera | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO28295 | Foeniculum vulgare | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO13106 | Rhodomyrtus tomentosa | Species | Myrtaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO19714 | Orthodon formosanus | Species | Cyprinidae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO3465 | Aconitum leucostomum | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO30338 | Piper nove | Species | Piperaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO21460 | Anethum graveolens | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO22104 | Trifolium pratense | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO8059 | Piper aduncum | Species | Piperaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO18951 | Ligusticum sinense | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO18141 | Solanum torvum | Species | Solanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO30699 | Masla dianthera | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO25276 | Ligusticum scoticum | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO13014 | Ipomoea cairica | Species | Convolvulaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO31073 | Ligusticum chuanxiong | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO8650 | Perilla frutescens | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO14948 | Brucea javanica | Species | Simaroubaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO22622 | Coptis deltoidea | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO14948 | Brucea javanica | Species | Simaroubaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO8650 | Perilla frutescens | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO21460 | Anethum graveolens | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO28928 | Piper nigrum | Species | Piperaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO28295 | Foeniculum vulgare | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO18951 | Ligusticum sinense | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO8892 | Sordaria araneosa | Species | Sordariaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO14057 | Apollonias barbujana | Species | Lauraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO8059 | Piper aduncum | Species | Piperaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21270 | Nerita albicilla | Species | Neritidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO13106 | Rhodomyrtus tomentosa | Species | Myrtaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO4004 | Aquilegia ecalcarata | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO8072 | Rudbeckia speciosa | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO14358 | Rhodobacter sphaeroides | Species | Rhodobacteraceae | Bacteria | n.a. | n.a. | n.a. | Database[UNPD] |
NPO16703 | Isodon lophanthoides | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO6873 | Salvia xalapensis | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO2649 | Ocotea aciphylla | Species | Lauraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO8650 | Perilla frutescens | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO12944 | Sideritis tragoriganum | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO8570 | Ficus elastica | Species | Moraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22622 | Coptis deltoidea | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11084 | Asplenium normale | Species | Aspleniaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO14845 | Ceratophyllum submersum | Species | Ceratophyllaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11432 | Centrolobium tomentosum | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20610 | Mosla dianthera | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22298 | Inula thapsoides | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO3164 | Yponomeuta malinellus | Species | Yponomeutidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21839 | Cymathere triplicata | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | Database[UNPD] |
NPO10757 | Cyanospira rippkae | Species | Aphanizomenonaceae | Bacteria | n.a. | n.a. | n.a. | Database[UNPD] |
NPO10550 | Artemisia hanseniana | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO3465 | Aconitum leucostomum | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21334 | Artemisia dracunculus | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO29262 | Cranfillia vulcanica | Species | Blechnaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20827 | Boronia muelleri | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20190 | Oxandra xylopioides | Species | Annonaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20508 | Ilex kaushue | Species | Aquifoliaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO1795 | Fragaria vesca | Species | Rosaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO13467 | Anarsia lineatella | Species | Gelechiidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25276 | Ligusticum scoticum | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO4671 | Persea mexicana | Species | Lauraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21023 | Astilbe koreana | Species | Saxifragaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO17581 | Streptomyces fulvoviridis | Species | Streptomycetaceae | Bacteria | n.a. | n.a. | n.a. | Database[UNPD] |
NPO14948 | Brucea javanica | Species | Simaroubaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO2243 | Euphorbia splendens | Species | Euphorbiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO14749 | Lippia carviodora | Species | Verbenaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20889 | Anastrepha suspensa | Species | Tephritidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO15871 | Parmelia enteromorpha | Species | Parmeliaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20316 | Hypselodoris cantabrica | Species | Chromodorididae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO14150 | Solanum jamaicense | Species | Solanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22104 | Trifolium pratense | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO13968 | Garcinia scortechinii | Species | Clusiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO12717 | Parmelia metastrigosa | Species | Parmeliaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO7016 | Gardenia tubifera | Species | Rubiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO28928 | Piper nigrum | Species | Piperaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO4771 | Tanacetum santolinoides | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO14162 | Chlorophytum borivilianum | Species | Asparagaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO1641 | Amycolatopsis azurea | Species | Pseudonocardiaceae | Bacteria | n.a. | n.a. | n.a. | Database[UNPD] |
NPO19953 | Lupinus formosus | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO9616 | Lunasia costulata | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20635 | Dalbergia frutescens | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22362 | Tylophora flava | Species | Apocynaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO12509 | Dipterocarpus dyeri | Species | Dipterocarpaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22880 | Aspergillus caespitosus | Species | Aspergillaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21557 | Woodsia manchuriensis | Species | Woodsiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO9203 | Cephalonomia gallicola | Species | Bethylidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO205 | Lasianthus fordii | Species | Rubiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11873 | Oecophylla smaragdina | Species | Formicidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO13766 | Ceanothus velutinus | Species | Rhamnaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22746 | Salix sieboldiana | Species | Salicaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22689 | Cassia carnaval | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21400 | Macrocystidia cucumis | Species | Tricholomataceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20045 | Burkholderia cepacia | Species | Burkholderiaceae | Bacteria | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20077 | Posoqueria latifolia | Species | Rubiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO211 | Aplysina cauliformis | Species | Aplysinidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO13014 | Ipomoea cairica | Species | Convolvulaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO18141 | Solanum torvum | Species | Solanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO12089 | Trifolium alexandrinum | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11998 | Ledebouria socialis | Species | Hyacinthaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20953 | Coprosma acerosa | Species | Rubiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11637 | Psilostrophe cooperi | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22042 | Kaunia arbuscularis | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO9108 | Leptotaenia multifida | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22490 | Limeum pterocarpum | Species | Limeaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO28295 | Foeniculum vulgare | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22227 | Sambucus ebulus | Species | Adoxaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21460 | Anethum graveolens | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20696 | Colchicum macedonicum | Species | Colchicaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO15146 | Myrica nana | Species | Myricaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21079 | Actinomadura hibisca | Species | Thermomonosporaceae | Bacteria | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21470 | Conoideocrella tenuis | Species | Clavicipitaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO14621 | Cuminum cyminum | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21587 | Hypericum papuanum | Species | Hypericaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21905 | Helianthopsis bishopii | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11492 | Kopsia grandifolia | Species | Apocynaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO24658 | Dillenia papuana | Species | Dilleniaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20764 | Euphorbia caducifolia | Species | Euphorbiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20134 | Dicliptera riparia | Species | Acanthaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO5191 | Penicillium cinerascens | Species | Aspergillaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO15520 | Dracocephalum kotschyi | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO10818 | Carpobrotus edulis | Species | Aizoaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20012 | Wunderlichia mirabilis | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO746 | Panax innovans | Species | Araliaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO18951 | Ligusticum sinense | Species | Apiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO5303 | Castanea crenata | Species | Fagaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO8068 | Blumea mollis | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO19880 | Palicourea alpina | Species | Rubiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO4785 | Persicaria thunbergii | Species | Polygonaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO26718 | Chelidonura fulvipunctata | Species | Aglajidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO19799 | Erwinia rhapontici | Species | Erwiniaceae | Bacteria | n.a. | n.a. | n.a. | Database[UNPD] |
NPO14528 | Pneumatospora obcoronata | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | Database[UNPD] |
NPO10293 | Diaporthe phaseolorum | Species | Diaporthaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21212 | Scrophularia smithii | Species | Scrophulariaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21775 | Zilla spinosa | Species | Brassicaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO12357 | Lycopus europaeus | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22551 | Trifolium alexandrium | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].
Organism ID | NP ID | Organism Material Preparation | Organism Part | NP Quantity (Standard) | NP Quantity (Minimum) | NP Quantity (Maximum) | Quantity Unit | Reference |
---|---|---|---|---|---|---|---|---|
NPO14621 | NPC283170 | Other | Seed | 15 | 15 | 15 | mg/100g | Database [DUKE] |
NPO21460 | NPC283170 | Raw | Seed | 2093.25 | 144 | 4042.5 | mg/100g | Database [DUKE] |
☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].
Target ID | Target Type | Target Name | Target Organism | Activity Type | Activity Relation | Value | Unit | Reference |
---|---|---|---|---|---|---|---|---|
NPT59 | Individual Protein | DNA polymerase beta | Homo sapiens | IC50 | > | 50000.0 | nM | PMID[494248] |
NPT20 | Organism | Candida albicans | Candida albicans | MIC | = | 500.0 | ug.mL-1 | PMID[494249] |
☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.
Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient
●  The left chart: Distribution of similarity level between NPC283170 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).
Similarity Score | Similarity Level | Natural Product ID |
---|---|---|
1.0 | High Similarity | NPC92869 |
1.0 | High Similarity | NPC191768 |
0.9829 | High Similarity | NPC211231 |
0.9487 | High Similarity | NPC119949 |
0.9322 | High Similarity | NPC308217 |
0.9316 | High Similarity | NPC33271 |
0.9153 | High Similarity | NPC52464 |
0.9153 | High Similarity | NPC304208 |
0.9032 | High Similarity | NPC52593 |
0.9032 | High Similarity | NPC473960 |
0.8992 | High Similarity | NPC73071 |
0.8984 | High Similarity | NPC58585 |
0.8934 | High Similarity | NPC285289 |
0.8923 | High Similarity | NPC197166 |
0.8917 | High Similarity | NPC474612 |
0.8864 | High Similarity | NPC284464 |
0.8862 | High Similarity | NPC270326 |
0.8855 | High Similarity | NPC20796 |
0.8846 | High Similarity | NPC240915 |
0.8837 | High Similarity | NPC471391 |
0.8837 | High Similarity | NPC471390 |
0.8814 | High Similarity | NPC204120 |
0.8797 | High Similarity | NPC300798 |
0.8797 | High Similarity | NPC58137 |
0.8788 | High Similarity | NPC9068 |
0.8788 | High Similarity | NPC6369 |
0.8788 | High Similarity | NPC30951 |
0.8769 | High Similarity | NPC145722 |
0.8769 | High Similarity | NPC7163 |
0.8769 | High Similarity | NPC185680 |
0.8769 | High Similarity | NPC256776 |
0.875 | High Similarity | NPC184814 |
0.875 | High Similarity | NPC63574 |
0.8731 | High Similarity | NPC472562 |
0.8731 | High Similarity | NPC80326 |
0.8731 | High Similarity | NPC174522 |
0.872 | High Similarity | NPC183446 |
0.8718 | High Similarity | NPC31279 |
0.8712 | High Similarity | NPC196420 |
0.871 | High Similarity | NPC264885 |
0.871 | High Similarity | NPC194626 |
0.8692 | High Similarity | NPC196937 |
0.8692 | High Similarity | NPC266848 |
0.8692 | High Similarity | NPC136750 |
0.8682 | High Similarity | NPC192255 |
0.8667 | High Similarity | NPC474808 |
0.8644 | High Similarity | NPC203924 |
0.8636 | High Similarity | NPC32189 |
0.8632 | High Similarity | NPC165386 |
0.8632 | High Similarity | NPC127326 |
0.8615 | High Similarity | NPC65183 |
0.8615 | High Similarity | NPC72046 |
0.8615 | High Similarity | NPC7744 |
0.8615 | High Similarity | NPC261812 |
0.8605 | High Similarity | NPC470624 |
0.8605 | High Similarity | NPC237169 |
0.8571 | High Similarity | NPC261714 |
0.8561 | High Similarity | NPC189474 |
0.855 | High Similarity | NPC112237 |
0.8537 | High Similarity | NPC475961 |
0.8537 | High Similarity | NPC254625 |
0.8527 | High Similarity | NPC58164 |
0.8527 | High Similarity | NPC228769 |
0.8527 | High Similarity | NPC153547 |
0.8527 | High Similarity | NPC470633 |
0.8527 | High Similarity | NPC10225 |
0.8519 | High Similarity | NPC312199 |
0.8516 | High Similarity | NPC474670 |
0.8516 | High Similarity | NPC202904 |
0.8516 | High Similarity | NPC189248 |
0.8507 | High Similarity | NPC53722 |
0.8507 | High Similarity | NPC201404 |
0.8507 | High Similarity | NPC290714 |
0.8507 | High Similarity | NPC292487 |
0.8504 | High Similarity | NPC64391 |
0.8496 | Intermediate Similarity | NPC172818 |
0.8496 | Intermediate Similarity | NPC25695 |
0.8496 | Intermediate Similarity | NPC143895 |
0.8485 | Intermediate Similarity | NPC474478 |
0.8485 | Intermediate Similarity | NPC31530 |
0.8478 | Intermediate Similarity | NPC162193 |
0.8478 | Intermediate Similarity | NPC33832 |
0.8462 | Intermediate Similarity | NPC51840 |
0.8462 | Intermediate Similarity | NPC224157 |
0.8462 | Intermediate Similarity | NPC234488 |
0.8462 | Intermediate Similarity | NPC258483 |
0.8462 | Intermediate Similarity | NPC240722 |
0.8462 | Intermediate Similarity | NPC192687 |
0.8462 | Intermediate Similarity | NPC311680 |
0.8462 | Intermediate Similarity | NPC244799 |
0.8462 | Intermediate Similarity | NPC299221 |
0.8455 | Intermediate Similarity | NPC63083 |
0.845 | Intermediate Similarity | NPC19694 |
0.8444 | Intermediate Similarity | NPC216434 |
0.8444 | Intermediate Similarity | NPC103448 |
0.8443 | Intermediate Similarity | NPC123948 |
0.8438 | Intermediate Similarity | NPC112596 |
0.8438 | Intermediate Similarity | NPC285725 |
0.8438 | Intermediate Similarity | NPC50683 |
0.8438 | Intermediate Similarity | NPC112571 |
0.8433 | Intermediate Similarity | NPC185908 |
0.8421 | Intermediate Similarity | NPC150534 |
0.8421 | Intermediate Similarity | NPC25333 |
0.8421 | Intermediate Similarity | NPC148893 |
0.8421 | Intermediate Similarity | NPC49235 |
0.8409 | Intermediate Similarity | NPC1474 |
0.8406 | Intermediate Similarity | NPC307466 |
0.8406 | Intermediate Similarity | NPC474749 |
0.8406 | Intermediate Similarity | NPC205316 |
0.8406 | Intermediate Similarity | NPC11422 |
0.8406 | Intermediate Similarity | NPC178014 |
0.8406 | Intermediate Similarity | NPC42716 |
0.84 | Intermediate Similarity | NPC472596 |
0.8387 | Intermediate Similarity | NPC15805 |
0.8387 | Intermediate Similarity | NPC20674 |
0.8385 | Intermediate Similarity | NPC27239 |
0.8385 | Intermediate Similarity | NPC190144 |
0.8385 | Intermediate Similarity | NPC150809 |
0.8385 | Intermediate Similarity | NPC123127 |
0.8372 | Intermediate Similarity | NPC474821 |
0.8372 | Intermediate Similarity | NPC242032 |
0.8359 | Intermediate Similarity | NPC105925 |
0.8358 | Intermediate Similarity | NPC104167 |
0.8358 | Intermediate Similarity | NPC11453 |
0.8358 | Intermediate Similarity | NPC121651 |
0.8357 | Intermediate Similarity | NPC301961 |
0.8357 | Intermediate Similarity | NPC166584 |
0.8346 | Intermediate Similarity | NPC474600 |
0.8333 | Intermediate Similarity | NPC6451 |
0.8333 | Intermediate Similarity | NPC319969 |
0.8333 | Intermediate Similarity | NPC137669 |
0.8333 | Intermediate Similarity | NPC477886 |
0.8321 | Intermediate Similarity | NPC474295 |
0.8321 | Intermediate Similarity | NPC229172 |
0.8321 | Intermediate Similarity | NPC184684 |
0.8321 | Intermediate Similarity | NPC103637 |
0.8321 | Intermediate Similarity | NPC311057 |
0.8321 | Intermediate Similarity | NPC476399 |
0.8321 | Intermediate Similarity | NPC133934 |
0.8321 | Intermediate Similarity | NPC184641 |
0.8321 | Intermediate Similarity | NPC36531 |
0.8321 | Intermediate Similarity | NPC41782 |
0.8321 | Intermediate Similarity | NPC230538 |
0.832 | Intermediate Similarity | NPC344161 |
0.832 | Intermediate Similarity | NPC222175 |
0.8308 | Intermediate Similarity | NPC31707 |
0.8308 | Intermediate Similarity | NPC165128 |
0.8308 | Intermediate Similarity | NPC158471 |
0.8308 | Intermediate Similarity | NPC57119 |
0.8308 | Intermediate Similarity | NPC222127 |
0.8308 | Intermediate Similarity | NPC266691 |
0.8308 | Intermediate Similarity | NPC226862 |
0.8308 | Intermediate Similarity | NPC82862 |
0.8296 | Intermediate Similarity | NPC474039 |
0.8296 | Intermediate Similarity | NPC283949 |
0.8295 | Intermediate Similarity | NPC103823 |
0.8295 | Intermediate Similarity | NPC28730 |
0.8295 | Intermediate Similarity | NPC88297 |
0.8295 | Intermediate Similarity | NPC214406 |
0.8295 | Intermediate Similarity | NPC186845 |
0.8295 | Intermediate Similarity | NPC44748 |
0.8295 | Intermediate Similarity | NPC474632 |
0.8295 | Intermediate Similarity | NPC223953 |
0.8295 | Intermediate Similarity | NPC78974 |
0.8295 | Intermediate Similarity | NPC18924 |
0.8295 | Intermediate Similarity | NPC223136 |
0.8295 | Intermediate Similarity | NPC9891 |
0.8286 | Intermediate Similarity | NPC116019 |
0.8284 | Intermediate Similarity | NPC236522 |
0.8284 | Intermediate Similarity | NPC474139 |
0.8284 | Intermediate Similarity | NPC234865 |
0.8273 | Intermediate Similarity | NPC476450 |
0.8273 | Intermediate Similarity | NPC180953 |
0.8271 | Intermediate Similarity | NPC215833 |
0.8271 | Intermediate Similarity | NPC36437 |
0.8271 | Intermediate Similarity | NPC233018 |
0.8271 | Intermediate Similarity | NPC69513 |
0.8271 | Intermediate Similarity | NPC241341 |
0.8268 | Intermediate Similarity | NPC246967 |
0.8268 | Intermediate Similarity | NPC135414 |
0.8268 | Intermediate Similarity | NPC261661 |
0.8268 | Intermediate Similarity | NPC474864 |
0.8261 | Intermediate Similarity | NPC81638 |
0.8261 | Intermediate Similarity | NPC324962 |
0.8261 | Intermediate Similarity | NPC76415 |
0.8261 | Intermediate Similarity | NPC218510 |
0.8258 | Intermediate Similarity | NPC82111 |
0.8258 | Intermediate Similarity | NPC232275 |
0.8258 | Intermediate Similarity | NPC45715 |
0.8258 | Intermediate Similarity | NPC12275 |
0.8258 | Intermediate Similarity | NPC474356 |
0.8258 | Intermediate Similarity | NPC469698 |
0.8258 | Intermediate Similarity | NPC227160 |
0.8258 | Intermediate Similarity | NPC473412 |
0.8244 | Intermediate Similarity | NPC45824 |
0.8239 | Intermediate Similarity | NPC474560 |
0.8235 | Intermediate Similarity | NPC113550 |
0.8231 | Intermediate Similarity | NPC246620 |
0.8231 | Intermediate Similarity | NPC8050 |
0.8231 | Intermediate Similarity | NPC82679 |
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.
●  The left chart: Distribution of similarity level between NPC283170 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).
Similarity Score | Similarity Level | Drug ID | Developmental Stage |
---|---|---|---|
0.8629 | High Similarity | NPD3705 | Approved |
0.8092 | Intermediate Similarity | NPD3018 | Phase 2 |
0.7984 | Intermediate Similarity | NPD2981 | Phase 2 |
0.797 | Intermediate Similarity | NPD3027 | Phase 3 |
0.7953 | Intermediate Similarity | NPD1357 | Approved |
0.7923 | Intermediate Similarity | NPD2982 | Phase 2 |
0.7923 | Intermediate Similarity | NPD2983 | Phase 2 |
0.7895 | Intermediate Similarity | NPD1529 | Clinical (unspecified phase) |
0.782 | Intermediate Similarity | NPD1530 | Clinical (unspecified phase) |
0.7794 | Intermediate Similarity | NPD1612 | Clinical (unspecified phase) |
0.7794 | Intermediate Similarity | NPD1613 | Approved |
0.7793 | Intermediate Similarity | NPD1653 | Approved |
0.776 | Intermediate Similarity | NPD5283 | Phase 1 |
0.7742 | Intermediate Similarity | NPD228 | Approved |
0.7724 | Intermediate Similarity | NPD6980 | Clinical (unspecified phase) |
0.7584 | Intermediate Similarity | NPD37 | Approved |
0.7534 | Intermediate Similarity | NPD1940 | Clinical (unspecified phase) |
0.7518 | Intermediate Similarity | NPD3539 | Phase 1 |
0.75 | Intermediate Similarity | NPD1091 | Approved |
0.7465 | Intermediate Similarity | NPD3540 | Phase 1 |
0.7464 | Intermediate Similarity | NPD554 | Clinical (unspecified phase) |
0.7434 | Intermediate Similarity | NPD4965 | Approved |
0.7434 | Intermediate Similarity | NPD4966 | Approved |
0.7434 | Intermediate Similarity | NPD4967 | Phase 2 |
0.7355 | Intermediate Similarity | NPD7199 | Phase 2 |
0.7343 | Intermediate Similarity | NPD1375 | Discontinued |
0.7338 | Intermediate Similarity | NPD6234 | Discontinued |
0.7328 | Intermediate Similarity | NPD1548 | Phase 1 |
0.7279 | Intermediate Similarity | NPD6143 | Clinical (unspecified phase) |
0.7261 | Intermediate Similarity | NPD7184 | Clinical (unspecified phase) |
0.726 | Intermediate Similarity | NPD5307 | Clinical (unspecified phase) |
0.7254 | Intermediate Similarity | NPD6111 | Discontinued |
0.7252 | Intermediate Similarity | NPD5536 | Phase 2 |
0.7239 | Intermediate Similarity | NPD1610 | Phase 2 |
0.7239 | Intermediate Similarity | NPD422 | Phase 1 |
0.719 | Intermediate Similarity | NPD2801 | Approved |
0.7179 | Intermediate Similarity | NPD5494 | Approved |
0.7161 | Intermediate Similarity | NPD7975 | Clinical (unspecified phase) |
0.7134 | Intermediate Similarity | NPD1247 | Approved |
0.7125 | Intermediate Similarity | NPD3818 | Discontinued |
0.7123 | Intermediate Similarity | NPD6674 | Discontinued |
0.7122 | Intermediate Similarity | NPD4908 | Phase 1 |
0.7095 | Intermediate Similarity | NPD7124 | Phase 2 |
0.7063 | Intermediate Similarity | NPD1772 | Clinical (unspecified phase) |
0.7054 | Intermediate Similarity | NPD1137 | Approved |
0.7054 | Intermediate Similarity | NPD1139 | Approved |
0.705 | Intermediate Similarity | NPD2861 | Phase 2 |
0.7047 | Intermediate Similarity | NPD5297 | Approved |
0.7039 | Intermediate Similarity | NPD6055 | Clinical (unspecified phase) |
0.7037 | Intermediate Similarity | NPD3496 | Discontinued |
0.7032 | Intermediate Similarity | NPD3817 | Phase 2 |
0.7027 | Intermediate Similarity | NPD2219 | Phase 1 |
0.7027 | Intermediate Similarity | NPD5084 | Clinical (unspecified phase) |
0.7021 | Intermediate Similarity | NPD4907 | Clinical (unspecified phase) |
0.7021 | Intermediate Similarity | NPD6859 | Clinical (unspecified phase) |
0.7019 | Intermediate Similarity | NPD7228 | Approved |
0.7016 | Intermediate Similarity | NPD940 | Approved |
0.7016 | Intermediate Similarity | NPD846 | Approved |
0.7013 | Intermediate Similarity | NPD3384 | Approved |
0.7013 | Intermediate Similarity | NPD1934 | Approved |
0.7013 | Intermediate Similarity | NPD3382 | Approved |
0.7013 | Intermediate Similarity | NPD3383 | Approved |
0.7008 | Intermediate Similarity | NPD1358 | Approved |
0.7008 | Intermediate Similarity | NPD290 | Approved |
0.7007 | Intermediate Similarity | NPD4749 | Approved |
0.7006 | Intermediate Similarity | NPD919 | Approved |
0.7 | Intermediate Similarity | NPD1138 | Approved |
0.7 | Intermediate Similarity | NPD1008 | Clinical (unspecified phase) |
0.7 | Intermediate Similarity | NPD1424 | Approved |
0.6987 | Remote Similarity | NPD3882 | Suspended |
0.6978 | Remote Similarity | NPD6917 | Clinical (unspecified phase) |
0.6975 | Remote Similarity | NPD7054 | Approved |
0.6972 | Remote Similarity | NPD1726 | Clinical (unspecified phase) |
0.697 | Remote Similarity | NPD709 | Approved |
0.697 | Remote Similarity | NPD6671 | Approved |
0.6957 | Remote Similarity | NPD2922 | Phase 1 |
0.6953 | Remote Similarity | NPD2684 | Approved |
0.6944 | Remote Similarity | NPD2492 | Phase 1 |
0.6933 | Remote Similarity | NPD1511 | Approved |
0.6933 | Remote Similarity | NPD4357 | Discontinued |
0.6933 | Remote Similarity | NPD7472 | Approved |
0.6933 | Remote Similarity | NPD7074 | Phase 3 |
0.6909 | Remote Similarity | NPD4338 | Clinical (unspecified phase) |
0.6892 | Remote Similarity | NPD4237 | Approved |
0.6892 | Remote Similarity | NPD1652 | Phase 2 |
0.6892 | Remote Similarity | NPD4236 | Phase 3 |
0.6889 | Remote Similarity | NPD5691 | Approved |
0.6884 | Remote Similarity | NPD4379 | Clinical (unspecified phase) |
0.6875 | Remote Similarity | NPD230 | Phase 1 |
0.6875 | Remote Similarity | NPD1933 | Approved |
0.6875 | Remote Similarity | NPD447 | Suspended |
0.6871 | Remote Similarity | NPD7266 | Discontinued |
0.687 | Remote Similarity | NPD7843 | Approved |
0.6861 | Remote Similarity | NPD1611 | Approved |
0.6859 | Remote Similarity | NPD2977 | Approved |
0.6859 | Remote Similarity | NPD2978 | Approved |
0.6848 | Remote Similarity | NPD7240 | Approved |
0.6842 | Remote Similarity | NPD1512 | Approved |
0.6842 | Remote Similarity | NPD7157 | Approved |
0.6839 | Remote Similarity | NPD5090 | Approved |
0.6839 | Remote Similarity | NPD5089 | Approved |
0.6838 | Remote Similarity | NPD4626 | Approved |
0.6835 | Remote Similarity | NPD6696 | Suspended |
0.6831 | Remote Similarity | NPD4625 | Phase 3 |
0.6824 | Remote Similarity | NPD970 | Clinical (unspecified phase) |
0.6815 | Remote Similarity | NPD6374 | Clinical (unspecified phase) |
0.6807 | Remote Similarity | NPD7808 | Phase 3 |
0.6806 | Remote Similarity | NPD1558 | Phase 1 |
0.6803 | Remote Similarity | NPD3454 | Phase 3 |
0.68 | Remote Similarity | NPD1242 | Phase 1 |
0.6788 | Remote Similarity | NPD6797 | Phase 2 |
0.6783 | Remote Similarity | NPD1296 | Phase 2 |
0.6783 | Remote Similarity | NPD5110 | Phase 2 |
0.6783 | Remote Similarity | NPD5111 | Phase 2 |
0.6783 | Remote Similarity | NPD6410 | Clinical (unspecified phase) |
0.6783 | Remote Similarity | NPD5109 | Approved |
0.6774 | Remote Similarity | NPD4675 | Approved |
0.6774 | Remote Similarity | NPD4678 | Approved |
0.677 | Remote Similarity | NPD6232 | Discontinued |
0.6768 | Remote Similarity | NPD5844 | Phase 1 |
0.6761 | Remote Similarity | NPD5752 | Clinical (unspecified phase) |
0.6755 | Remote Similarity | NPD5058 | Phase 3 |
0.6755 | Remote Similarity | NPD6783 | Clinical (unspecified phase) |
0.6752 | Remote Similarity | NPD2393 | Clinical (unspecified phase) |
0.6752 | Remote Similarity | NPD4585 | Approved |
0.6747 | Remote Similarity | NPD7251 | Discontinued |
0.6733 | Remote Similarity | NPD1878 | Clinical (unspecified phase) |
0.6732 | Remote Similarity | NPD1349 | Approved |
0.6732 | Remote Similarity | NPD1350 | Approved |
0.6732 | Remote Similarity | NPD1351 | Approved |
0.673 | Remote Similarity | NPD4055 | Discovery |
0.6728 | Remote Similarity | NPD3926 | Phase 2 |
0.6715 | Remote Similarity | NPD1778 | Approved |
0.6714 | Remote Similarity | NPD8651 | Approved |
0.6713 | Remote Similarity | NPD2669 | Clinical (unspecified phase) |
0.6711 | Remote Similarity | NPD1372 | Clinical (unspecified phase) |
0.671 | Remote Similarity | NPD4005 | Discontinued |
0.6691 | Remote Similarity | NPD1182 | Approved |
0.669 | Remote Similarity | NPD1240 | Approved |
0.6689 | Remote Similarity | NPD2935 | Discontinued |
0.6667 | Remote Similarity | NPD289 | Clinical (unspecified phase) |
0.6667 | Remote Similarity | NPD6788 | Approved |
0.6667 | Remote Similarity | NPD4868 | Clinical (unspecified phase) |
0.6667 | Remote Similarity | NPD3134 | Approved |
0.6667 | Remote Similarity | NPD5718 | Phase 2 |
0.6667 | Remote Similarity | NPD968 | Approved |
0.6667 | Remote Similarity | NPD7028 | Phase 2 |
0.6647 | Remote Similarity | NPD6559 | Discontinued |
0.6646 | Remote Similarity | NPD5677 | Discontinued |
0.6646 | Remote Similarity | NPD7473 | Discontinued |
0.6645 | Remote Similarity | NPD4210 | Discontinued |
0.6644 | Remote Similarity | NPD3657 | Discovery |
0.6643 | Remote Similarity | NPD3600 | Clinical (unspecified phase) |
0.6643 | Remote Similarity | NPD596 | Approved |
0.6643 | Remote Similarity | NPD600 | Approved |
0.6641 | Remote Similarity | NPD556 | Approved |
0.6641 | Remote Similarity | NPD5451 | Approved |
0.6641 | Remote Similarity | NPD4750 | Phase 3 |
0.6625 | Remote Similarity | NPD4381 | Clinical (unspecified phase) |
0.6623 | Remote Similarity | NPD7466 | Approved |
0.6623 | Remote Similarity | NPD7314 | Clinical (unspecified phase) |
0.6622 | Remote Similarity | NPD6029 | Clinical (unspecified phase) |
0.6622 | Remote Similarity | NPD3748 | Approved |
0.6622 | Remote Similarity | NPD1510 | Phase 2 |
0.6622 | Remote Similarity | NPD6028 | Clinical (unspecified phase) |
0.6621 | Remote Similarity | NPD2674 | Phase 3 |
0.6621 | Remote Similarity | NPD839 | Approved |
0.6621 | Remote Similarity | NPD840 | Approved |
0.6618 | Remote Similarity | NPD1408 | Clinical (unspecified phase) |
0.6617 | Remote Similarity | NPD5535 | Approved |
0.6614 | Remote Similarity | NPD291 | Approved |
0.6607 | Remote Similarity | NPD7549 | Discontinued |
0.6604 | Remote Similarity | NPD5353 | Approved |
0.6603 | Remote Similarity | NPD7261 | Clinical (unspecified phase) |
0.6601 | Remote Similarity | NPD6799 | Approved |
0.6601 | Remote Similarity | NPD1774 | Approved |
0.6599 | Remote Similarity | NPD1607 | Approved |
0.6599 | Remote Similarity | NPD2653 | Approved |
0.6594 | Remote Similarity | NPD17 | Approved |
0.6593 | Remote Similarity | NPD6387 | Discontinued |
0.6585 | Remote Similarity | NPD6166 | Phase 2 |
0.6585 | Remote Similarity | NPD6167 | Clinical (unspecified phase) |
0.6585 | Remote Similarity | NPD6168 | Clinical (unspecified phase) |
0.6581 | Remote Similarity | NPD920 | Approved |
0.6577 | Remote Similarity | NPD2796 | Approved |
0.6575 | Remote Similarity | NPD4060 | Phase 1 |
0.6575 | Remote Similarity | NPD3620 | Phase 2 |
0.6575 | Remote Similarity | NPD3619 | Clinical (unspecified phase) |
0.6573 | Remote Similarity | NPD9494 | Approved |
0.6571 | Remote Similarity | NPD1840 | Phase 2 |
0.6569 | Remote Similarity | NPD7534 | Approved |
0.6569 | Remote Similarity | NPD7533 | Approved |
0.6564 | Remote Similarity | NPD3787 | Discontinued |
0.6558 | Remote Similarity | NPD2532 | Approved |
0.6558 | Remote Similarity | NPD3688 | Clinical (unspecified phase) |
0.6558 | Remote Similarity | NPD2533 | Approved |
0.6558 | Remote Similarity | NPD4739 | Approved |
0.6558 | Remote Similarity | NPD3146 | Approved |
0.6558 | Remote Similarity | NPD2534 | Approved |
0.6556 | Remote Similarity | NPD5698 | Clinical (unspecified phase) |
Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.
Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.