Structure

Physi-Chem Properties

Molecular Weight:  275.06
Volume:  273.445
LogP:  3.606
LogD:  2.998
LogS:  -6.373
# Rotatable Bonds:  0
TPSA:  48.42
# H-Bond Aceptor:  4
# H-Bond Donor:  0
# Rings:  5
# Heavy Atoms:  4

MedChem Properties

QED Drug-Likeness Score:  0.494
Synthetic Accessibility Score:  2.527
Fsp3:  0.059
Lipinski Rule-of-5:  Accepted
Pfizer Rule:  Rejected
GSK Rule:  Accepted
BMS Rule:  0
Golden Triangle Rule:  Accepted
Chelating Alert:  0
PAINS Alert:  0

ADMET Properties (ADMETlab2.0)

ADMET: Absorption

Caco-2 Permeability:  -4.863
MDCK Permeability:  1.903005068015773e-05
Pgp-inhibitor:  0.198
Pgp-substrate:  0.0
Human Intestinal Absorption (HIA):  0.003
20% Bioavailability (F20%):  0.002
30% Bioavailability (F30%):  0.389

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):  0.294
Plasma Protein Binding (PPB):  97.98394012451172%
Volume Distribution (VD):  0.853
Pgp-substrate:  1.5818431377410889%

ADMET: Metabolism

CYP1A2-inhibitor:  0.976
CYP1A2-substrate:  0.169
CYP2C19-inhibitor:  0.879
CYP2C19-substrate:  0.099
CYP2C9-inhibitor:  0.628
CYP2C9-substrate:  0.879
CYP2D6-inhibitor:  0.74
CYP2D6-substrate:  0.821
CYP3A4-inhibitor:  0.82
CYP3A4-substrate:  0.135

ADMET: Excretion

Clearance (CL):  11.173
Half-life (T1/2):  0.121

ADMET: Toxicity

hERG Blockers:  0.043
Human Hepatotoxicity (H-HT):  0.222
Drug-inuced Liver Injury (DILI):  0.955
AMES Toxicity:  0.92
Rat Oral Acute Toxicity:  0.053
Maximum Recommended Daily Dose:  0.87
Skin Sensitization:  0.131
Carcinogencity:  0.946
Eye Corrosion:  0.004
Eye Irritation:  0.651
Respiratory Toxicity:  0.878

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General Info & Identifiers & Properties  
Structure MOL file  
Source Organisms  
Biological Activities  
Similar NPs/Drugs  

  Natural Product: NPC278525

Natural Product ID:  NPC278525
Common Name*:   Liriodenine
IUPAC Name:   n.a.
Synonyms:   Hiriodenine; Liriodenine
Standard InCHIKey:  MUMCCPUVOAUBAN-UHFFFAOYSA-N
Standard InCHI:  InChI=1S/C17H9NO3/c19-16-11-4-2-1-3-10(11)14-13-9(5-6-18-15(13)16)7-12-17(14)21-8-20-12/h1-7H,8H2
SMILES:  c1ccc2c(-c3c4c(ccnc4C2=O)cc2c3OCO2)c1
Synthetic Gene Cluster:   n.a.
ChEMBL Identifier:   CHEMBL37736
PubChem CID:   10144
Chemical Classification**:  
  • CHEMONTID:0000000 [Organic compounds]
    • [CHEMONTID:0000279] Alkaloids and derivatives
      • [CHEMONTID:0000381] Aporphines

*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO6333 Annona glabra Species Annonaceae Eukaryota n.a. stem wood n.a. DOI[10.1021/np100247r]
NPO9632 Annona reticulata Species Annonaceae Eukaryota n.a. stem n.a. DOI[10.1021/np50053a043]
NPO19242 Eucalyptus albens Species Myrtaceae Eukaryota flowers n.a. n.a. PMID[10075775]
NPO16788 Syzygium formosanum Species Myrtaceae Eukaryota Leaves n.a. n.a. PMID[10075776]
NPO6333 Annona glabra Species Annonaceae Eukaryota n.a. n.a. n.a. PMID[10395501]
NPO6333 Annona glabra Species Annonaceae Eukaryota n.a. n.a. n.a. PMID[10425140]
NPO15299 Sandoricum koetjape Species Meliaceae Eukaryota n.a. n.a. n.a. PMID[10479314]
NPO11164 Renealmia alpinia Species Zingiberaceae Eukaryota n.a. n.a. n.a. PMID[10479331]
NPO12483 Holarrhena floribunda Species Apocynaceae Eukaryota n.a. n.a. n.a. PMID[10650079]
NPO2884 Annona squamosa Species Annonaceae Eukaryota seeds n.a. n.a. PMID[11141125]
NPO10210 Artabotrys uncinatus Species Annonaceae Eukaryota n.a. n.a. n.a. PMID[11575948]
NPO4041 Guatteria multivenia Species Annonaceae Eukaryota Roots n.a. n.a. PMID[12088427]
NPO28923 Allium fistulosum Species Amaryllidaceae Eukaryota n.a. seed n.a. PMID[12381110]
NPO2884 Annona squamosa Species Annonaceae Eukaryota n.a. n.a. n.a. PMID[12398544]
NPO15275 Briareum asbestinum Species Briareidae Eukaryota n.a. n.a. n.a. PMID[12662092]
NPO15866 Goniothalamus amuyon Species Annonaceae Eukaryota n.a. n.a. n.a. PMID[12713398]
NPO15299 Sandoricum koetjape Species Meliaceae Eukaryota stems n.a. n.a. PMID[1517737]
NPO19436 Annona cherimola Species Annonaceae Eukaryota Seeds n.a. n.a. PMID[15387664]
NPO6333 Annona glabra Species Annonaceae Eukaryota Fruits n.a. n.a. PMID[15568797]
NPO13353 Sedum sarmentosum Species Crassulaceae Eukaryota n.a. aerial part n.a. PMID[15577228]
NPO19620 Stemona tuberosa Species Stemonaceae Eukaryota n.a. n.a. n.a. PMID[15679323]
NPO8520 Mucor spinosus Species Mucoraceae Eukaryota n.a. n.a. n.a. PMID[15844967]
NPO13465 Salvia broussonetii Species Lamiaceae Eukaryota roots n.a. n.a. PMID[15969497]
NPO12483 Holarrhena floribunda Species Apocynaceae Eukaryota n.a. n.a. n.a. PMID[16441070]
NPO7436 Annona foetida Species Annonaceae Eukaryota n.a. n.a. n.a. PMID[16499336]
NPO19620 Stemona tuberosa Species Stemonaceae Eukaryota roots n.a. n.a. PMID[16643052]
NPO15275 Briareum asbestinum Species Briareidae Eukaryota n.a. Caribbean n.a. PMID[1686898]
NPO19620 Stemona tuberosa Species Stemonaceae Eukaryota Roots; Stems; Tubers n.a. n.a. PMID[16872143]
NPO21404 Anagallis monelli Species Primulaceae Eukaryota n.a. aerial part n.a. PMID[17329877]
NPO15866 Goniothalamus amuyon Species Annonaceae Eukaryota n.a. n.a. n.a. PMID[1791473]
NPO11791 Magnolia obovata Species Magnoliaceae Eukaryota n.a. stem n.a. PMID[18175990]
NPO9650 Zanthoxylum nitidum Species Rutaceae Eukaryota Stems; Barks n.a. n.a. PMID[18303853]
NPO9650 Zanthoxylum nitidum Species Rutaceae Eukaryota stem bark n.a. n.a. PMID[18303853]
NPO2884 Annona squamosa Species Annonaceae Eukaryota n.a. n.a. n.a. PMID[18419154]
NPO19620 Stemona tuberosa Species Stemonaceae Eukaryota roots n.a. n.a. PMID[18452334]
NPO19083 Alstonia angustiloba Species Apocynaceae Eukaryota n.a. n.a. n.a. PMID[18524603]
NPO2884 Annona squamosa Species Annonaceae Eukaryota n.a. n.a. n.a. PMID[19296389]
NPO12483 Holarrhena floribunda Species Apocynaceae Eukaryota n.a. n.a. n.a. PMID[19299148]
NPO27979 Guatteria friesiana Species Annonaceae Eukaryota Stems n.a. n.a. PMID[19639965]
NPO10501 Mitrephora glabra Species Annonaceae Eukaryota stem bark n.a. n.a. PMID[19874044]
NPO3478 Nelumbo nucifera Species Nelumbonaceae Eukaryota n.a. n.a. n.a. PMID[19919095]
NPO32767 guatteria hispida Species Annonaceae Eukaryota bark n.a. n.a. PMID[20476748]
NPO28923 Allium fistulosum Species Amaryllidaceae Eukaryota Seeds Zigong, Sichuan Province, China 2004-SEP PMID[20515043]
NPO19592 Michelia alba Species Magnoliaceae Eukaryota leaves n.a. n.a. PMID[20584613]
NPO6333 Annona glabra Species Annonaceae Eukaryota stem Taipei Botanical Garden, Taipei, Taiwan, China 2006-MAR PMID[20828184]
NPO17759 Rhododendron mucronulatum Species Ericaceae Eukaryota n.a. stem n.a. PMID[21443171]
NPO11791 Magnolia obovata Species Magnoliaceae Eukaryota n.a. n.a. n.a. PMID[21625478]
NPO30067 Polyalthia longifolia Species Annonaceae Eukaryota n.a. n.a. n.a. PMID[21872367]
NPO19620 Stemona tuberosa Species Stemonaceae Eukaryota n.a. rhizome n.a. PMID[21902195]
NPO19620 Stemona tuberosa Species Stemonaceae Eukaryota n.a. tuberous root n.a. PMID[21902195]
NPO2884 Annona squamosa Species Annonaceae Eukaryota n.a. n.a. n.a. PMID[21910504]
NPO12425 Combretum griffithii Species Combretaceae Eukaryota n.a. stem n.a. PMID[21919533]
NPO2884 Annona squamosa Species Annonaceae Eukaryota n.a. seed n.a. PMID[22011319]
NPO2884 Annona squamosa Species Annonaceae Eukaryota seeds n.a. n.a. PMID[22011319]
NPO13353 Sedum sarmentosum Species Crassulaceae Eukaryota n.a. n.a. n.a. PMID[22085682]
NPO15299 Sandoricum koetjape Species Meliaceae Eukaryota n.a. n.a. n.a. PMID[22672802]
NPO30067 Polyalthia longifolia Species Annonaceae Eukaryota n.a. n.a. n.a. PMID[2292689]
NPO3478 Nelumbo nucifera Species Nelumbonaceae Eukaryota flower buds and leaves Khon Kaen province, Thailand 2010 PMID[23270663]
NPO2350 Microcos paniculata Species Malvaceae Eukaryota n.a. n.a. n.a. PMID[23327794]
NPO1168 Euphorbia sikkimensis Species Euphorbiaceae Eukaryota n.a. n.a. n.a. PMID[23327832]
NPO2884 Annona squamosa Species Annonaceae Eukaryota Barks n.a. n.a. PMID[2348205]
NPO12721 Liriodendron tulipifera Species Magnoliaceae Eukaryota n.a. n.a. n.a. PMID[23501116]
NPO18602 Melampodium leucanthum Species Asteraceae Eukaryota n.a. n.a. n.a. PMID[23501116]
NPO3478 Nelumbo nucifera Species Nelumbonaceae Eukaryota Leaves n.a. n.a. PMID[23642481]
NPO12425 Combretum griffithii Species Combretaceae Eukaryota Stems n.a. n.a. PMID[23795891]
NPO22181 Leibnitzia anandria Species Asteraceae Eukaryota n.a. n.a. n.a. PMID[24699147]
NPO6333 Annona glabra Species Annonaceae Eukaryota fruits n.a. n.a. PMID[25499882]
NPO18602 Melampodium leucanthum Species Asteraceae Eukaryota leaves and branches n.a. n.a. PMID[25685941]
NPO18602 Melampodium leucanthum Species Asteraceae Eukaryota leaves and branches San Antonio, Texas 2004-JUN PMID[25685941]
NPO21410 Populus balsamifera Species Salicaceae Eukaryota Buds n.a. n.a. PMID[25927817]
NPO17612 Xanthium sibiricum Species Asteraceae Eukaryota Fruits n.a. n.a. PMID[26110443]
NPO17296 Beesia calthifolia Species Ranunculaceae Eukaryota n.a. n.a. n.a. PMID[26238319]
NPO3478 Nelumbo nucifera Species Nelumbonaceae Eukaryota Flowers n.a. n.a. PMID[26462418]
NPO1168 Euphorbia sikkimensis Species Euphorbiaceae Eukaryota n.a. n.a. n.a. PMID[26756779]
NPO13745 Gynoxys verrucosa Species Asteraceae Eukaryota n.a. n.a. n.a. PMID[27057812]
NPO27979 Guatteria friesiana Species Annonaceae Eukaryota Barks n.a. n.a. PMID[27300257]
NPO40530 Polyalthia cerasoides Species Annonaceae Eukaryota n.a. n.a. n.a. PMID[27490091]
NPO26659 Annona bullata Species Annonaceae Eukaryota n.a. n.a. n.a. PMID[2778448]
NPO15190 Chloranthus fortunei Species Chloranthaceae Eukaryota n.a. n.a. n.a. PMID[27997206]
NPO6698 Euphorbia pithyusa Species Euphorbiaceae Eukaryota n.a. n.a. n.a. PMID[28671832]
NPO18676 Clerodendrum trichotomum Species Lamiaceae Eukaryota Roots n.a. n.a. PMID[29924604]
NPO12352 Magnolia baillonii Species Magnoliaceae Eukaryota n.a. n.a. n.a. PMID[3437284]
NPO20412 Magnolia grandiflora Species Magnoliaceae Eukaryota Wood n.a. n.a. PMID[7119806]
NPO16455 Xylopia aethiopica Species Annonaceae Eukaryota n.a. n.a. n.a. PMID[8158166]
NPO33359 miliusa cf. banacea Species Annonaceae Eukaryota n.a. n.a. n.a. PMID[8158166]
NPO9632 Annona reticulata Species Annonaceae Eukaryota n.a. n.a. n.a. PMID[8277309]
NPO26659 Annona bullata Species Annonaceae Eukaryota n.a. n.a. n.a. PMID[8350089]
NPO32735 guatteria scbmburgkiana Species Annonaceae Eukaryota n.a. n.a. n.a. PMID[8676127]
NPO2884 Annona squamosa Species Annonaceae Eukaryota n.a. fruit n.a. PMID[8786370]
NPO2884 Annona squamosa Species Annonaceae Eukaryota bark n.a. n.a. PMID[9214729]
NPO23076 Illigera luzonensis Species Hernandiaceae Eukaryota n.a. n.a. n.a. PMID[9214740]
NPO11164 Renealmia alpinia Species Zingiberaceae Eukaryota n.a. Suriname rainforest n.a. PMID[9428162]
NPO6333 Annona glabra Species Annonaceae Eukaryota n.a. n.a. n.a. PMID[9584397]
NPO6333 Annona glabra Species Annonaceae Eukaryota n.a. n.a. n.a. PMID[9599260]
NPO8583 Angelica japonica Species Apiaceae Eukaryota n.a. root n.a. PMID[9987830]
NPO3478 Nelumbo nucifera Species Nelumbonaceae Eukaryota Fruit n.a. n.a. Database[FooDB]
NPO2884 Annona squamosa Species Annonaceae Eukaryota Fruit n.a. n.a. Database[FooDB]
NPO3938 Cucurbita pepo Species Cucurbitaceae Eukaryota Fruit n.a. n.a. Database[FooDB]
NPO3478 Nelumbo nucifera Species Nelumbonaceae Eukaryota Rhizome n.a. n.a. Database[FooDB]
NPO10532 Pinus edulis Species Pinaceae Eukaryota Seed n.a. n.a. Database[FooDB]
NPO19436 Annona cherimola Species Annonaceae Eukaryota Seed n.a. n.a. Database[FooDB]
NPO3478 Nelumbo nucifera Species Nelumbonaceae Eukaryota Seed n.a. n.a. Database[FooDB]
NPO3938 Cucurbita pepo Species Cucurbitaceae Eukaryota n.a. n.a. Database[FooDB]
NPO9632 Annona reticulata Species Annonaceae Eukaryota n.a. n.a. Database[FooDB]
NPO19436 Annona cherimola Species Annonaceae Eukaryota n.a. n.a. Database[FooDB]
NPO28923 Allium fistulosum Species Amaryllidaceae Eukaryota n.a. n.a. Database[FooDB]
NPO9632 Annona reticulata Species Annonaceae Eukaryota Bark n.a. n.a. Database[FooDB]
NPO17336 Benincasa hispida Species Cucurbitaceae Eukaryota n.a. n.a. Database[FooDB]
NPO17336 Benincasa hispida Species Cucurbitaceae Eukaryota Fruit n.a. n.a. Database[FooDB]
NPO3478 Nelumbo nucifera Species Nelumbonaceae Eukaryota n.a. n.a. Database[FooDB]
NPO19436 Annona cherimola Species Annonaceae Eukaryota Fruit n.a. n.a. Database[FooDB]
NPO2884 Annona squamosa Species Annonaceae Eukaryota n.a. n.a. Database[FooDB]
NPO9632 Annona reticulata Species Annonaceae Eukaryota Fruit n.a. n.a. Database[FooDB]
NPO10532 Pinus edulis Species Pinaceae Eukaryota n.a. n.a. Database[FooDB]
NPO19436 Annona cherimola Species Annonaceae Eukaryota n.a. n.a. Database[FooDB]
NPO9632 Annona reticulata Species Annonaceae Eukaryota n.a. n.a. Database[FooDB]
NPO2884 Annona squamosa Species Annonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO21410 Populus balsamifera Species Salicaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO21685 Magnolia coco Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO3938 Cucurbita pepo Species Cucurbitaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO13737 Tephroseris kirilowii Species Asteraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO20412 Magnolia grandiflora Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO17336 Benincasa hispida Species Cucurbitaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO15866 Goniothalamus amuyon Species Annonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO19620 Stemona tuberosa Species Stemonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO17612 Xanthium sibiricum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO7844 Fritillaria hupehensis Species Liliaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO28923 Allium fistulosum Species Amaryllidaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO25658 Rumex japonicus Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO26659 Annona bullata Species Annonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO19769 Boschniakia rossica Species Orobanchaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO1909 Michelia lanuginosa Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO13018 Thelephora aurantiotincta Species Thelephoraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO10625 Fissistigma glaucescens Species Annonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO18765 Juniperus scopulorum Species Cupressaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO6333 Annona glabra Species Annonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO1783 Euonymus fortunei Species Celastraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO16308 Citrus wilsonii Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO12483 Holarrhena floribunda Species Apocynaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO29748 Tsoongiodendron odorum Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO19592 Michelia alba Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO13228 Farfugium japonicum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO19403 Epimedium grandiflorum Species Berberidaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO12351 Lettowianthus stellatus Species Annonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO13353 Sedum sarmentosum Species Crassulaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO17759 Rhododendron mucronulatum Species Ericaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO14991 Zanthoxylum cuspidatum Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO3478 Nelumbo nucifera Species Nelumbonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO9650 Zanthoxylum nitidum Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO8583 Angelica japonica Species Apiaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO29756 Aquilaria agallocha Species Thymelaeaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO11791 Magnolia obovata Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO7002 Ardisia hortorum Species Primulaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO9632 Annona reticulata Species Annonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO14407 Stachyurus praecox Species Stachyuraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO10210 Artabotrys uncinatus Species Annonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO28711 Artabotrys hexapetalus Species Annonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO5725 Stephania dinklagei Species Menispermaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO30870 Michelia champaca Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO3371 Podocarpus nubigenus Species Podocarpaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO12721 Liriodendron tulipifera Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO3800 Indigofera arrecta Species Fabaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO30067 Polyalthia longifolia Species Annonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO28923 Allium fistulosum Species Amaryllidaceae Eukaryota n.a. n.a. Database[Phenol-Explorer]
NPO16308 Citrus wilsonii Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO8583 Angelica japonica Species Apiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO11967 Delphinium giraldii Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO14991 Zanthoxylum cuspidatum Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO21410 Populus balsamifera Species Salicaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO22452 Leucanthemum vulgare Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO28711 Artabotrys hexapetalus Species Annonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO19620 Stemona tuberosa Species Stemonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO13737 Tephroseris kirilowii Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO13810 Magnolia champaca Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO10210 Artabotrys uncinatus Species Annonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO2884 Annona squamosa Species Annonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO17296 Beesia calthifolia Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO17759 Rhododendron mucronulatum Species Ericaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO19592 Michelia alba Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO14233 Ormosia dasycarpa Species Limoniidae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO6333 Annona glabra Species Annonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO18676 Clerodendrum trichotomum Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO25457 Anemone anhuiensis Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO7002 Ardisia hortorum Species Primulaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO12483 Holarrhena floribunda Species Apocynaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO18765 Juniperus scopulorum Species Cupressaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO14407 Stachyurus praecox Species Stachyuraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO3938 Cucurbita pepo Species Cucurbitaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO12351 Lettowianthus stellatus Species Annonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO1909 Michelia lanuginosa Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO17336 Benincasa hispida Species Cucurbitaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO13353 Sedum sarmentosum Species Crassulaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO8485 Magnolia odora Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO15866 Goniothalamus amuyon Species Annonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO3482 Alpinia flabellata Species Zingiberaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO21685 Magnolia coco Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO13228 Farfugium japonicum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO17612 Xanthium sibiricum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO26659 Annona bullata Species Annonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO15299 Sandoricum koetjape Species Meliaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO9632 Annona reticulata Species Annonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO12721 Liriodendron tulipifera Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO9133 Lathyrus latifolius Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO9650 Zanthoxylum nitidum Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO5725 Stephania dinklagei Species Menispermaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO7844 Fritillaria hupehensis Species Liliaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO24402.1 Coffea liberica var. dewevrei Varieties Rubiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO13018 Thelephora aurantiotincta Species Thelephoraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO2350 Microcos paniculata Species Malvaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO3800 Indigofera arrecta Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO13358 Piper brachystachyum Species Piperaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO19769 Boschniakia rossica Species Orobanchaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO3478 Nelumbo nucifera Species Nelumbonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO28923 Allium fistulosum Species Amaryllidaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO22181 Leibnitzia anandria Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO11791 Magnolia obovata Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO19403 Epimedium grandiflorum Species Berberidaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO25658 Rumex japonicus Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO10625 Fissistigma glaucescens Species Annonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO12265 Aquilaria agallochum Species Thymelaeaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO1783 Euonymus fortunei Species Celastraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO3371 Podocarpus nubigenus Species Podocarpaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO20412 Magnolia grandiflora Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO3371 Podocarpus nubigenus Species Podocarpaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO28711 Artabotrys hexapetalus Species Annonaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO21685 Magnolia coco Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO30870 Michelia champaca Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO19769 Boschniakia rossica Species Orobanchaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO20412 Magnolia grandiflora Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO29756 Aquilaria agallocha Species Thymelaeaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO14991 Zanthoxylum cuspidatum Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO3938 Cucurbita pepo Species Cucurbitaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO28923 Allium fistulosum Species Amaryllidaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO16308 Citrus wilsonii Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO18765 Juniperus scopulorum Species Cupressaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO21410 Populus balsamifera Species Salicaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO2884 Annona squamosa Species Annonaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO12721 Liriodendron tulipifera Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO1909 Michelia lanuginosa Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO13353 Sedum sarmentosum Species Crassulaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO9650 Zanthoxylum nitidum Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO3478 Nelumbo nucifera Species Nelumbonaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO9133 Lathyrus latifolius Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO11791 Magnolia obovata Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO17166 Euphorbia palustris Species Euphorbiaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO17336 Benincasa hispida Species Cucurbitaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO25658 Rumex japonicus Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO19592 Michelia alba Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO9632 Annona reticulata Species Annonaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO17759 Rhododendron mucronulatum Species Ericaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO17612 Xanthium sibiricum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO19620 Stemona tuberosa Species Stemonaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO13228 Farfugium japonicum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO7844 Fritillaria hupehensis Species Liliaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO3478 Nelumbo nucifera Species Nelumbonaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO9650 Zanthoxylum nitidum Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO17612 Xanthium sibiricum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO25658 Rumex japonicus Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO13353 Sedum sarmentosum Species Crassulaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO16308 Citrus wilsonii Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO12265 Aquilaria agallochum Species Thymelaeaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO17336 Benincasa hispida Species Cucurbitaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO11791 Magnolia obovata Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO2350 Microcos paniculata Species Malvaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO19403 Epimedium grandiflorum Species Berberidaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO20412 Magnolia grandiflora Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO5455 Euploca racemosa Species Heliotropiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23076 Illigera luzonensis Species Hernandiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9650 Zanthoxylum nitidum Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12223 Stellaria media Species Caryophyllaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11236 Mycale mytilorum Species Mycalidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22452 Leucanthemum vulgare Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13228 Farfugium japonicum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16798 Piper sylvaticum Species Piperaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3371 Podocarpus nubigenus Species Podocarpaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19170 Lasianthaea podocephala Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11791 Magnolia obovata Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13247 Stevia pilosa Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18424 Selinum libanotis Species Apiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24402.1 Coffea liberica var. dewevrei Varieties Rubiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14407 Stachyurus praecox Species Stachyuraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15299 Sandoricum koetjape Species Meliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3938 Cucurbita pepo Species Cucurbitaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO27979 Guatteria friesiana Species Annonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17759 Rhododendron mucronulatum Species Ericaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13465 Salvia broussonetii Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12992 Shigella boydii Species Enterobacteriaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO20965 Oxytropis lanata Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16325 Sideritis dasygnaphala Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18927 Clinacanthus nutans Species Acanthaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4563 Clinopodium acinos Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17499 Bursera kerberi Species Burseraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23743 Camoensia maxima Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8721 Parectatosoma mocquerysi Species Anisacanthidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6236 Polymastia boletiformis Species Polymastiidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22629 Spongia vaginalis Species Spongiidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25370 Botrychium ternatum Species Ophioglossaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2292 Teclea verdoorniana Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13101 Passiflora hybrid Species Passifloraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21404 Anagallis monelli Species Primulaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4424 Salvia amplexicaulis Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17114 Streptomyces melanogenes Species Streptomycetaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO15020 Flindersia amboinensis Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14329 Sigillina signifera Species Polycitoridae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22545 Plectranthus crassus Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22181 Leibnitzia anandria Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO29450 Streptomyces parvisporogenes Species Streptomycetaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO15862 Eminium lehmannii Species Araceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15275 Briareum asbestinum Species Briareidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8485 Magnolia odora Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23897 Lobophytum strictum Species Alcyoniidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13018 Thelephora aurantiotincta Species Thelephoraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7844 Fritillaria hupehensis Species Liliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19668.1 Euphorbia characias subsp. wulfenii Subspecies Euphorbiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12425 Combretum griffithii Species Combretaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19436 Annona cherimola Species Annonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12870 Curcuma aeruginosa Species Zingiberaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11081 Baccharis grandicapitulata Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14236 Physalis coztomatl Species Solanaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10210 Artabotrys uncinatus Species Annonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12018 Alternaria bataticola Species Pleosporaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7436 Annona foetida Species Annonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17166 Euphorbia palustris Species Euphorbiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25681 Diospyros consolatae Species Ebenaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14194 Mamestra brassicae Species 0ctuidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22942 Moesziomyces antarcticus Species Ustilaginaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11164 Renealmia alpinia Species Zingiberaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13646 Phlebia strigosozonata Species Meruliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14233 Ormosia dasycarpa Species Limoniidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14455 Triunia erythrocarpa Species Proteaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18026 Bipolaris sacchari Species Pleosporaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18765 Juniperus scopulorum Species Cupressaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4679 Hedysarum gmelini Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25431 Anthemis cotula Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1843 Laurelia sempervirens Species Atherospermataceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3800 Indigofera arrecta Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO28711 Artabotrys hexapetalus Species Annonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16135 Pestalotiopsis oenotherae Species Sporocadaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17612 Xanthium sibiricum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17230 Psidium acutangulum Species Myrtaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26659 Annona bullata Species Annonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO28923 Allium fistulosum Species Amaryllidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20581 Sargassum fulvellum Species Sargassaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18602 Melampodium leucanthum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21468 Dilophus guineensis Species Dictyotaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7009 Callyspongia spinosissima Species Callyspongiidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16981 Gutierrezia dracunculoides Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12483 Holarrhena floribunda Species Apocynaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20329 Gymnacranthera paniculata Species Myristicaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18676 Clerodendrum trichotomum Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4973 Cirsium rivulare Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19709 Pseudocyphellaria australiensis Species Lobariaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19620 Stemona tuberosa Species Stemonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25346 Eucalyptus cneorifolia Species Myrtaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15405 Suaeda maritima Species Chenopodiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12351 Lettowianthus stellatus Species Annonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13353 Sedum sarmentosum Species Crassulaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10517 Aconitum vilmorini Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14567 Ursinia anethoides Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19769 Boschniakia rossica Species Orobanchaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15127 Senecio congestus Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2043 Pseudocyphellaria coronata Species Lobariaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO27148 Chuquiraga erinacea Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3482 Alpinia flabellata Species Zingiberaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12721 Liriodendron tulipifera Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12265 Aquilaria agallochum Species Thymelaeaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4041 Guatteria multivenia Species Annonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19242 Eucalyptus albens Species Myrtaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11646 Morella pensylvanica Species Myricaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6337 Cinchona rosulenta Species Rubiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1222 Baccharis scoparia Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6982 Cheimophila salicella n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO16455 Xylopia aethiopica Species Annonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6333 Annona glabra Species Annonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2360 Jatropha mahafalensis Species Euphorbiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25403 Alstonia villosa Species Apocynaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19083 Alstonia angustiloba Species Apocynaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13358 Piper brachystachyum Species Piperaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11373 0nomuraea spiralis Species Streptosporangiaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO7993 Euclea pseudebenus Species Ebenaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19371 Costasiella ocellifera Species Costasiellidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22727 Avena fatua Species Poaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12914 Sarcophyton flexuosum Species Alcyoniidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18333 Sphaerophysa salsula Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17964 Aspergillus subolivaceus Species Aspergillaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18262 Aspergillus microcysticus Species Aspergillaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2884 Annona squamosa Species Annonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19572 Pellacalyx axillaris Species Rhizophoraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20704 Conus gladiator Species Conidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15887 Absidia orchidis Species Cunninghamellaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19888 Doronicum grandiflorum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1909 Michelia lanuginosa Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15992 Hypogymnia vittata Species Parmeliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12769 Hosta sieboldii Species Asparagaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13810 Magnolia champaca Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18048 Phlomis crinita Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO29531 Lupinus cosentinii Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10423 Sibthorpia europaea Species Plantaginaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16308 Citrus wilsonii Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7002 Ardisia hortorum Species Primulaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22498 Lithocarpus haipinii Species Fagaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9538 Pterocarpus erinaceus Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11592 Cuphea hyssopifolia Species Lythraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3478 Nelumbo nucifera Species Nelumbonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13737 Tephroseris kirilowii Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18348 Crotalaria stolzii Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2568 Posidonia oceanica Species Posidoniaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17358 Sorbus torminalis Species Rosaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10048 Pyrus bourgaeana Species Rosaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13861 Niphates rowi Species Niphatidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22436 Lora quadra n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO17354 Micromonospora echinospora Species Micromonosporaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO2070 Thioalkalivibrio versutus Species Ectothiorhodospiraceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO17296 Beesia calthifolia Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3090 Verbascum undulatum Species Scrophulariaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4282 Fouquieria diguetii Species Fouquieriaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11967 Delphinium giraldii Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8172 Emericellopsis minima Species n.a. Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9133 Lathyrus latifolius Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16788 Syzygium formosanum Species Myrtaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1168 Euphorbia sikkimensis Species Euphorbiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO27877 Eliokarmos thyrsoides Species Hyacinthaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17630 Helenium integrifolium Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15190 Chloranthus fortunei Species Chloranthaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12352 Magnolia baillonii Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25658 Rumex japonicus Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6698 Euphorbia pithyusa Species Euphorbiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1783 Euonymus fortunei Species Celastraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2350 Microcos paniculata Species Malvaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18533 Delisea elegans Species Bonnemaisoniaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20325 Dictyodendrilla cavernosa Species Dictyodendrillidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13617 Eria rigida Species Orchidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13389 Cystoseira barbatula Species Sargassaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15802 Papaver pseudocanescens Species Papaveraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO968 Artemisia pectinata Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10532 Pinus edulis Species Pinaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21780 Strychnos gossweileri Species Loganiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17336 Benincasa hispida Species Cucurbitaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21410 Populus balsamifera Species Salicaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18894 Karenia mikimotoi Species Kareniaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10358 Bupleurum gerardi Species Apiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21685 Magnolia coco Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18169 Creosphaeria sassafras Species Xylariaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21569 Helichrysum fulvum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9632 Annona reticulata Species Annonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13745 Gynoxys verrucosa Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4717 Laserpitium siler Species Apiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15514 Pedicularis rex Species Orobanchaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2680 Holothuria squamifera Species Holothuriidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO5725 Stephania dinklagei Species Menispermaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO273 Phyllobates bicolor Species Dendrobatidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1798 Duguetia obovata Species Annonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19403 Epimedium grandiflorum Species Berberidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25612 Polyalthia microtus Species Annonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8583 Angelica japonica Species Apiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15866 Goniothalamus amuyon Species Annonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO5998 Echinoclathria subhispida Species Microcionidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19592 Michelia alba Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9906 Zephyranthes flava Species Amaryllidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8520 Mucor spinosus Species Mucoraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10562 Aglaia archboldiana Species Meliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25118 Centaurea benedicta Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10501 Mitrephora glabra Species Annonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10905 Baccharis truncata Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11246 Ononis viscosa Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25457 Anemone anhuiensis Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9769 Mortonia palmeri Species Celastraceae Eukaryota n.a. n.a. n.a. Database[UNPD]

☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

  NP Quantity Composition/Concentration

Organism ID NP ID Organism Material Preparation Organism Part NP Quantity (Standard) NP Quantity (Minimum) NP Quantity (Maximum) Quantity Unit Reference

☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT4163 Individual Protein Protein tyrosine phosphatase receptor type C-associated protein Homo sapiens IC50 = 182000.0 nM PMID[511283]
NPT1857 Individual Protein Dopamine D1 receptor Rattus norvegicus IC50 = 75000.0 nM PMID[511284]
NPT1858 Individual Protein Dopamine D2 receptor Rattus norvegicus IC50 = 59000.0 nM PMID[511284]
NPT1073 Individual Protein Dopamine transporter Rattus norvegicus IC50 = 31000.0 nM PMID[511284]
NPT91 Cell Line KB Homo sapiens ED50 = 1.0 ug ml-1 PMID[511286]
NPT81 Cell Line A549 Homo sapiens ED50 = 0.72 ug ml-1 PMID[511286]
NPT180 Cell Line HCT-8 Homo sapiens ED50 = 0.7 ug ml-1 PMID[511286]
NPT168 Cell Line P388 Mus musculus ED50 = 0.57 ug ml-1 PMID[511286]
NPT137 Cell Line L1210 Mus musculus ED50 = 2.33 ug ml-1 PMID[511286]
NPT91 Cell Line KB Homo sapiens ED50 = 3.1 ug ml-1 PMID[511289]
NPT1073 Individual Protein Dopamine transporter Rattus norvegicus IC50 = 31200.0 nM PMID[511292]
NPT189 Cell Line Vero Chlorocebus aethiops CC50 = 48000.0 nM PMID[511294]
NPT189 Cell Line Vero Chlorocebus aethiops MTC = 31.0 uM PMID[511294]
NPT91 Cell Line KB Homo sapiens IC50 = 5000.0 nM PMID[511297]
NPT83 Cell Line MCF7 Homo sapiens IC50 = 5000.0 nM PMID[511297]
NPT397 Cell Line NCI-H460 Homo sapiens IC50 = 5000.0 nM PMID[511297]
NPT395 Cell Line SF-268 Homo sapiens IC50 = 5000.0 nM PMID[511297]
NPT66 Individual Protein Acetylcholinesterase Electrophorus electricus IC50 > 150000.0 nM PMID[511299]
NPT368 Cell Line SN12C Homo sapiens GI50 n.a. 4977.37 nM PMID[511300]
NPT368 Cell Line SN12C Homo sapiens GI50 n.a. 5821.03 nM PMID[511301]
NPT369 Cell Line ACHN Homo sapiens GI50 n.a. 3935.5 nM PMID[511300]
NPT370 Cell Line NCI-H23 Homo sapiens GI50 n.a. 4045.76 nM PMID[511300]
NPT369 Cell Line ACHN Homo sapiens GI50 n.a. 4315.19 nM PMID[511301]
NPT370 Cell Line NCI-H23 Homo sapiens GI50 n.a. 5395.11 nM PMID[511301]
NPT371 Cell Line UO-31 Homo sapiens GI50 n.a. 4943.11 nM PMID[511301]
NPT372 Cell Line HOP-92 Homo sapiens GI50 n.a. 8689.6 nM PMID[511301]
NPT371 Cell Line UO-31 Homo sapiens GI50 n.a. 3419.79 nM PMID[511300]
NPT372 Cell Line HOP-92 Homo sapiens GI50 n.a. 5610.48 nM PMID[511300]
NPT116 Cell Line HL-60 Homo sapiens GI50 n.a. 2999.16 nM PMID[511300]
NPT373 Cell Line SK-MEL-5 Homo sapiens GI50 n.a. 2837.92 nM PMID[511300]
NPT374 Cell Line SF-539 Homo sapiens GI50 n.a. 3531.83 nM PMID[511300]
NPT374 Cell Line SF-539 Homo sapiens GI50 n.a. 7979.95 nM PMID[511301]
NPT111 Cell Line K562 Homo sapiens GI50 n.a. 3419.79 nM PMID[511300]
NPT375 Cell Line Malme-3M Homo sapiens GI50 n.a. 3589.22 nM PMID[511300]
NPT375 Cell Line Malme-3M Homo sapiens GI50 n.a. 3026.91 nM PMID[511301]
NPT111 Cell Line K562 Homo sapiens GI50 n.a. 4285.49 nM PMID[511301]
NPT376 Cell Line A498 Homo sapiens GI50 n.a. 3483.37 nM PMID[511300]
NPT377 Cell Line OVCAR-3 Homo sapiens GI50 n.a. 9246.98 nM PMID[511301]
NPT112 Cell Line MOLT-4 Homo sapiens GI50 n.a. 3380.65 nM PMID[511301]
NPT377 Cell Line OVCAR-3 Homo sapiens GI50 n.a. 10471.29 nM PMID[511300]
NPT112 Cell Line MOLT-4 Homo sapiens GI50 n.a. 3672.82 nM PMID[511300]
NPT379 Cell Line HOP-62 Homo sapiens GI50 n.a. 3890.45 nM PMID[511300]
NPT380 Cell Line U-251 Homo sapiens GI50 n.a. 6324.12 nM PMID[511301]
NPT381 Cell Line OVCAR-8 Homo sapiens GI50 n.a. 4036.45 nM PMID[511301]
NPT380 Cell Line U-251 Homo sapiens GI50 n.a. 5445.03 nM PMID[511300]
NPT381 Cell Line OVCAR-8 Homo sapiens GI50 n.a. 5140.44 nM PMID[511300]
NPT382 Cell Line OVCAR-5 Homo sapiens GI50 n.a. 16943.38 nM PMID[511300]
NPT382 Cell Line OVCAR-5 Homo sapiens GI50 n.a. 11481.54 nM PMID[511301]
NPT383 Cell Line SNB-19 Homo sapiens GI50 n.a. 5675.45 nM PMID[511300]
NPT572 Cell Line DMS-273 Homo sapiens GI50 n.a. 3443.5 nM PMID[511300]
NPT383 Cell Line SNB-19 Homo sapiens GI50 n.a. 7998.34 nM PMID[511301]
NPT572 Cell Line DMS-273 Homo sapiens GI50 n.a. 5457.58 nM PMID[511301]
NPT384 Cell Line TK-10 Homo sapiens GI50 n.a. 10185.91 nM PMID[511300]
NPT384 Cell Line TK-10 Homo sapiens GI50 n.a. 3019.95 nM PMID[511301]
NPT455 Cell Line NCI-H522 Homo sapiens GI50 n.a. 4255.98 nM PMID[511300]
NPT323 Cell Line SW-620 Homo sapiens GI50 n.a. 4920.4 nM PMID[511300]
NPT573 Cell Line M19-MEL Homo sapiens GI50 n.a. 5861.38 nM PMID[511301]
NPT573 Cell Line M19-MEL Homo sapiens GI50 n.a. 3749.73 nM PMID[511300]
NPT323 Cell Line SW-620 Homo sapiens GI50 n.a. 3819.44 nM PMID[511301]
NPT386 Cell Line KM12 Homo sapiens GI50 n.a. 6441.69 nM PMID[511300]
NPT386 Cell Line KM12 Homo sapiens GI50 n.a. 6501.3 nM PMID[511301]
NPT455 Cell Line NCI-H522 Homo sapiens GI50 n.a. 885.12 nM PMID[511301]
NPT574 Cell Line XF498 Homo sapiens GI50 n.a. 5754.4 nM PMID[511301]
NPT387 Cell Line M14 Homo sapiens GI50 n.a. 7533.56 nM PMID[511300]
NPT388 Cell Line NCI-H322M Homo sapiens GI50 n.a. 6011.74 nM PMID[511300]
NPT574 Cell Line XF498 Homo sapiens GI50 n.a. 4688.13 nM PMID[511300]
NPT387 Cell Line M14 Homo sapiens GI50 n.a. 6714.29 nM PMID[511301]
NPT389 Cell Line RPMI-8226 Homo sapiens GI50 n.a. 3198.9 nM PMID[511300]
NPT388 Cell Line NCI-H322M Homo sapiens GI50 n.a. 11220.18 nM PMID[511301]
NPT389 Cell Line RPMI-8226 Homo sapiens GI50 n.a. 3483.37 nM PMID[511301]
NPT456 Cell Line OVCAR-4 Homo sapiens GI50 n.a. 5069.91 nM PMID[511300]
NPT390 Cell Line LOX IMVI Homo sapiens GI50 n.a. 3767.04 nM PMID[511300]
NPT456 Cell Line OVCAR-4 Homo sapiens GI50 n.a. 8241.38 nM PMID[511301]
NPT390 Cell Line LOX IMVI Homo sapiens GI50 n.a. 4216.97 nM PMID[511301]
NPT147 Cell Line SK-MEL-2 Homo sapiens GI50 n.a. 4187.94 nM PMID[511300]
NPT147 Cell Line SK-MEL-2 Homo sapiens GI50 n.a. 5997.91 nM PMID[511301]
NPT575 Cell Line KM-20L2 Homo sapiens GI50 n.a. 7144.96 nM PMID[511301]
NPT575 Cell Line KM-20L2 Homo sapiens GI50 n.a. 5821.03 nM PMID[511300]
NPT391 Cell Line HCC 2998 Homo sapiens GI50 n.a. 4508.17 nM PMID[511300]
NPT81 Cell Line A549 Homo sapiens GI50 n.a. 3475.36 nM PMID[511300]
NPT81 Cell Line A549 Homo sapiens GI50 n.a. 3467.37 nM PMID[511301]
NPT392 Cell Line SNB-75 Homo sapiens GI50 n.a. 4178.3 nM PMID[511300]
NPT392 Cell Line SNB-75 Homo sapiens GI50 n.a. 5997.91 nM PMID[511301]
NPT393 Cell Line HCT-116 Homo sapiens GI50 n.a. 3288.52 nM PMID[511301]
NPT148 Cell Line HCT-15 Homo sapiens GI50 n.a. 4897.79 nM PMID[511300]
NPT393 Cell Line HCT-116 Homo sapiens GI50 n.a. 3169.57 nM PMID[511300]
NPT148 Cell Line HCT-15 Homo sapiens GI50 n.a. 4415.7 nM PMID[511301]
NPT394 Cell Line EKVX Homo sapiens GI50 n.a. 3459.39 nM PMID[511301]
NPT395 Cell Line SF-268 Homo sapiens GI50 n.a. 6137.62 nM PMID[511300]
NPT395 Cell Line SF-268 Homo sapiens GI50 n.a. 6025.6 nM PMID[511301]
NPT394 Cell Line EKVX Homo sapiens GI50 n.a. 5152.29 nM PMID[511300]
NPT731 Cell Line LXFL 529 Homo sapiens GI50 n.a. 5888.44 nM PMID[511301]
NPT576 Cell Line DMS-114 Homo sapiens GI50 n.a. 10046.16 nM PMID[511301]
NPT731 Cell Line LXFL 529 Homo sapiens GI50 n.a. 6516.28 nM PMID[511300]
NPT576 Cell Line DMS-114 Homo sapiens GI50 n.a. 4875.28 nM PMID[511300]
NPT146 Cell Line SK-OV-3 Homo sapiens GI50 n.a. 22233.1 nM PMID[511300]
NPT146 Cell Line SK-OV-3 Homo sapiens GI50 n.a. 17864.88 nM PMID[511301]
NPT397 Cell Line NCI-H460 Homo sapiens GI50 n.a. 3589.22 nM PMID[511301]
NPT397 Cell Line NCI-H460 Homo sapiens GI50 n.a. 3341.95 nM PMID[511300]
NPT398 Cell Line UACC-62 Homo sapiens GI50 n.a. 4570.88 nM PMID[511301]
NPT308 Cell Line CAKI-1 Homo sapiens GI50 n.a. 3630.78 nM PMID[511300]
NPT308 Cell Line CAKI-1 Homo sapiens GI50 n.a. 3767.04 nM PMID[511301]
NPT398 Cell Line UACC-62 Homo sapiens GI50 n.a. 2766.94 nM PMID[511300]
NPT399 Cell Line SF-295 Homo sapiens GI50 n.a. 6123.5 nM PMID[511300]
NPT458 Cell Line IGROV-1 Homo sapiens GI50 n.a. 5970.35 nM PMID[511301]
NPT399 Cell Line SF-295 Homo sapiens GI50 n.a. 4864.07 nM PMID[511301]
NPT458 Cell Line IGROV-1 Homo sapiens GI50 n.a. 3899.42 nM PMID[511300]
NPT401 Cell Line 786-0 Homo sapiens GI50 n.a. 4246.2 nM PMID[511301]
NPT577 Cell Line RXF 631 Homo sapiens GI50 n.a. 4539.42 nM PMID[511301]
NPT577 Cell Line RXF 631 Homo sapiens GI50 n.a. 4226.69 nM PMID[511300]
NPT401 Cell Line 786-0 Homo sapiens GI50 n.a. 7691.3 nM PMID[511300]
NPT578 Cell Line SNB-78 Homo sapiens GI50 n.a. 14927.94 nM PMID[511301]
NPT578 Cell Line SNB-78 Homo sapiens GI50 n.a. 6039.49 nM PMID[511300]
NPT403 Cell Line UACC-257 Homo sapiens GI50 n.a. 2588.21 nM PMID[511300]
NPT403 Cell Line UACC-257 Homo sapiens GI50 n.a. 5236.0 nM PMID[511301]
NPT579 Cell Line DLD-1 Homo sapiens GI50 n.a. 4487.45 nM PMID[511301]
NPT579 Cell Line DLD-1 Homo sapiens GI50 n.a. 4045.76 nM PMID[511300]
NPT404 Cell Line CCRF-CEM Homo sapiens GI50 n.a. 4102.04 nM PMID[511301]
NPT404 Cell Line CCRF-CEM Homo sapiens GI50 n.a. 2697.74 nM PMID[511300]
NPT139 Cell Line HT-29 Homo sapiens GI50 n.a. 4954.5 nM PMID[511300]
NPT405 Cell Line NCI-H226 Homo sapiens GI50 n.a. 4688.13 nM PMID[511300]
NPT139 Cell Line HT-29 Homo sapiens GI50 n.a. 4055.09 nM PMID[511301]
NPT405 Cell Line NCI-H226 Homo sapiens GI50 n.a. 5272.3 nM PMID[511301]
NPT170 Cell Line SK-MEL-28 Homo sapiens GI50 n.a. 5584.7 nM PMID[511300]
NPT406 Cell Line RXF 393 Homo sapiens GI50 n.a. 5546.26 nM PMID[511300]
NPT170 Cell Line SK-MEL-28 Homo sapiens GI50 n.a. 5272.3 nM PMID[511301]
NPT406 Cell Line RXF 393 Homo sapiens GI50 n.a. 5058.25 nM PMID[511301]
NPT407 Cell Line COLO 205 Homo sapiens GI50 n.a. 4786.3 nM PMID[511301]
NPT407 Cell Line COLO 205 Homo sapiens GI50 n.a. 4236.43 nM PMID[511300]
NPT732 Cell Line HOP-18 Homo sapiens GI50 n.a. 24888.57 nM PMID[511301]
NPT139 Cell Line HT-29 Homo sapiens IC50 > 10000.0 nM PMID[511303]
NPT2719 Individual Protein Voltage-gated L-type calcium channel alpha-1C subunit Rattus norvegicus IC50 = 2500.0 nM PMID[511305]
NPT113 Cell Line RAW264.7 Mus musculus IC50 = 34700.0 nM PMID[511307]
NPT169 Cell Line B16-F10 Mus musculus IC50 > 10000.0 nM PMID[511308]
NPT65 Cell Line HepG2 Homo sapiens IC50 = 8300.0 nM PMID[511308]
NPT116 Cell Line HL-60 Homo sapiens IC50 = 5500.0 nM PMID[511308]
NPT111 Cell Line K562 Homo sapiens IC50 = 5000.0 nM PMID[511308]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. ED50 = 1.6 ug ml-1 PMID[511285]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 50.0 % PMID[511287]
NPT1208 Organism Leishmania braziliensis Leishmania braziliensis Activity = 90.0 % PMID[511287]
NPT634 Organism Leishmania amazonensis Leishmania amazonensis Activity = 100.0 ug ml-1 PMID[511287]
NPT634 Organism Leishmania amazonensis Leishmania amazonensis Activity = 90.0 % PMID[511287]
NPT633 Organism Leishmania donovani Leishmania donovani Activity = 100.0 ug ml-1 PMID[511287]
NPT633 Organism Leishmania donovani Leishmania donovani Activity = 90.0 % PMID[511287]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. Activity = 5.4 % PMID[511288]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. Activity = 40.5 % PMID[511288]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. Activity = 5.3 % PMID[511288]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. Activity = 84.1 % PMID[511288]
NPT312 Organism Saccharomyces cerevisiae Saccharomyces cerevisiae Activity = 16.7 ug ml-1 PMID[511290]
NPT312 Organism Saccharomyces cerevisiae Saccharomyces cerevisiae IZ = 15.0 mm PMID[511290]
NPT312 Organism Saccharomyces cerevisiae Saccharomyces cerevisiae Activity = 500.0 ug ml-1 PMID[511290]
NPT140 Organism Artemia Artemia LC50 = 1.1 ug.mL-1 PMID[511291]
NPT2 Others Unspecified Ratio IC50 = 2.4 n.a. PMID[511292]
NPT2 Others Unspecified Ratio IC50 = 1.9 n.a. PMID[511292]
NPT20 Organism Candida albicans Candida albicans IC50 = 3.5 ug.mL-1 PMID[511293]
NPT20 Organism Candida albicans Candida albicans MIC = 6.25 ug.mL-1 PMID[511293]
NPT85 Organism Filobasidiella neoformans Cryptococcus neoformans MIC = 12.5 ug.mL-1 PMID[511293]
NPT85 Organism Filobasidiella neoformans Cryptococcus neoformans IC50 = 2.0 ug.mL-1 PMID[511293]
NPT16 Organism Staphylococcus aureus Staphylococcus aureus IC50 = 2.0 ug.mL-1 PMID[511293]
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 3.13 ug.mL-1 PMID[511293]
NPT1208 Organism Leishmania braziliensis Leishmania braziliensis IC50 = 58500.0 nM PMID[511295]
NPT3631 Organism Leishmania guyanensis Leishmania guyanensis IC50 = 21500.0 nM PMID[511295]
NPT19 Organism Escherichia coli Escherichia coli MIC > 1000.0 ug.mL-1 PMID[511296]
NPT3721 Organism Enterococcus hirae Enterococcus hirae MIC = 600.0 ug.mL-1 PMID[511296]
NPT1531 Organism Enterococcus faecium Enterococcus faecium MIC = 150.0 ug.mL-1 PMID[511296]
NPT20 Organism Candida albicans Candida albicans MIC > 1000.0 ug.mL-1 PMID[511296]
NPT79 Organism Bacillus subtilis Bacillus subtilis MIC = 500.0 ug.mL-1 PMID[511296]
NPT729 Organism Micrococcus luteus Micrococcus luteus MIC = 150.0 ug.mL-1 PMID[511296]
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC > 1000.0 ug.mL-1 PMID[511296]
NPT4805 Organism Rhodococcus equi Rhodococcus equi MIC = 10.0 ug.mL-1 PMID[511296]
NPT1190 Organism Salmonella enterica Salmonella enterica MIC > 1000.0 ug.mL-1 PMID[511296]
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC > 1000.0 ug.mL-1 PMID[511296]
NPT729 Organism Micrococcus luteus Micrococcus luteus MIC = 6.3 ug.mL-1 PMID[511297]
NPT602 Organism Mycobacterium smegmatis Mycobacterium smegmatis MIC = 12.0 ug.mL-1 PMID[511297]
NPT312 Organism Saccharomyces cerevisiae Saccharomyces cerevisiae MIC = 12.0 ug.mL-1 PMID[511297]
NPT21 Organism Aspergillus niger Aspergillus niger MIC = 25.0 ug.mL-1 PMID[511297]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. Activity = 0.3 n.a. PMID[511298]
NPT17 Organism Staphylococcus epidermidis Staphylococcus epidermidis MIC = 50.0 ug.mL-1 PMID[511298]
NPT2580 Organism Candida dubliniensis Candida dubliniensis MIC = 50.0 ug.mL-1 PMID[511298]
NPT2580 Organism Candida dubliniensis Candida dubliniensis MIC = 100.0 ug.mL-1 PMID[511298]
NPT88 Organism Mycobacterium tuberculosis Mycobacterium tuberculosis MIC = 12.5 ug.mL-1 PMID[511302]
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Inhibition = 13.3 % PMID[511303]
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens Inhibition = 19.3 % PMID[511303]
NPT610 Others Molecular identity unknown IC50 = 600.0 nM PMID[511306]
NPT2 Others Unspecified IC50 = 56800.0 nM PMID[511307]
NPT2 Others Unspecified IC50 = 34800.0 nM PMID[511308]

☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.

  Chemically structural similarity: I. Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC278525 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.9854 High Similarity NPC22481
0.976 High Similarity NPC108342
0.9713 High Similarity NPC189903
0.9713 High Similarity NPC182907
0.9608 High Similarity NPC210434
0.9575 High Similarity NPC210296
0.9573 High Similarity NPC166722
0.9442 High Similarity NPC124313
0.9439 High Similarity NPC207283
0.9439 High Similarity NPC84164
0.9333 High Similarity NPC24019
0.9227 High Similarity NPC183537
0.9155 High Similarity NPC233334
0.914 High Similarity NPC77878
0.907 High Similarity NPC90875
0.9029 High Similarity NPC236668
0.8986 High Similarity NPC146976
0.8889 High Similarity NPC251160
0.8869 High Similarity NPC15406
0.8807 High Similarity NPC253675
0.8702 High Similarity NPC470020
0.8465 Intermediate Similarity NPC270515
0.8451 Intermediate Similarity NPC235076
0.8447 Intermediate Similarity NPC234197
0.8447 Intermediate Similarity NPC477019
0.8436 Intermediate Similarity NPC188420
0.8394 Intermediate Similarity NPC322482
0.8333 Intermediate Similarity NPC23614
0.8333 Intermediate Similarity NPC100079
0.8318 Intermediate Similarity NPC149471
0.8318 Intermediate Similarity NPC271215
0.8295 Intermediate Similarity NPC46451
0.8282 Intermediate Similarity NPC119134
0.8271 Intermediate Similarity NPC171409
0.8271 Intermediate Similarity NPC53069
0.8271 Intermediate Similarity NPC96405
0.8271 Intermediate Similarity NPC296482
0.8271 Intermediate Similarity NPC202768
0.8235 Intermediate Similarity NPC470018
0.8208 Intermediate Similarity NPC313189
0.8208 Intermediate Similarity NPC135549
0.8198 Intermediate Similarity NPC74575
0.8182 Intermediate Similarity NPC118121
0.8165 Intermediate Similarity NPC204446
0.8107 Intermediate Similarity NPC133140
0.8107 Intermediate Similarity NPC195268
0.81 Intermediate Similarity NPC216612
0.8053 Intermediate Similarity NPC49547
0.8042 Intermediate Similarity NPC132385
0.7975 Intermediate Similarity NPC478045
0.7948 Intermediate Similarity NPC470017
0.7945 Intermediate Similarity NPC55470
0.7944 Intermediate Similarity NPC476581
0.7944 Intermediate Similarity NPC16452
0.7944 Intermediate Similarity NPC36229
0.7937 Intermediate Similarity NPC122463
0.792 Intermediate Similarity NPC246381
0.7913 Intermediate Similarity NPC470022
0.7877 Intermediate Similarity NPC4071
0.7877 Intermediate Similarity NPC476578
0.7877 Intermediate Similarity NPC476582
0.7804 Intermediate Similarity NPC31930
0.7778 Intermediate Similarity NPC72905
0.7773 Intermediate Similarity NPC137353
0.7745 Intermediate Similarity NPC142385
0.7712 Intermediate Similarity NPC208522
0.771 Intermediate Similarity NPC5374
0.7692 Intermediate Similarity NPC41501
0.7692 Intermediate Similarity NPC202605
0.7692 Intermediate Similarity NPC112206
0.7682 Intermediate Similarity NPC290689
0.767 Intermediate Similarity NPC206201
0.7664 Intermediate Similarity NPC23080
0.7664 Intermediate Similarity NPC193906
0.7647 Intermediate Similarity NPC220337
0.7626 Intermediate Similarity NPC193238
0.7626 Intermediate Similarity NPC308943
0.7611 Intermediate Similarity NPC174049
0.7533 Intermediate Similarity NPC54066
0.7524 Intermediate Similarity NPC204385
0.7511 Intermediate Similarity NPC94842
0.7511 Intermediate Similarity NPC122436
0.751 Intermediate Similarity NPC134637
0.75 Intermediate Similarity NPC318068
0.75 Intermediate Similarity NPC71124
0.7477 Intermediate Similarity NPC254957
0.7476 Intermediate Similarity NPC249405
0.7466 Intermediate Similarity NPC222561
0.7459 Intermediate Similarity NPC303374
0.7458 Intermediate Similarity NPC235685
0.7445 Intermediate Similarity NPC473822
0.7439 Intermediate Similarity NPC129897
0.7436 Intermediate Similarity NPC471004
0.7426 Intermediate Similarity NPC101350
0.7424 Intermediate Similarity NPC280799
0.7411 Intermediate Similarity NPC208284
0.7386 Intermediate Similarity NPC107123
0.7384 Intermediate Similarity NPC472061
0.7361 Intermediate Similarity NPC146724
0.7345 Intermediate Similarity NPC232225
0.7342 Intermediate Similarity NPC300156
0.7339 Intermediate Similarity NPC191489
0.7331 Intermediate Similarity NPC329631
0.733 Intermediate Similarity NPC207971
0.7319 Intermediate Similarity NPC260434
0.7319 Intermediate Similarity NPC474688
0.7297 Intermediate Similarity NPC268077
0.7277 Intermediate Similarity NPC100573
0.7277 Intermediate Similarity NPC82548
0.7277 Intermediate Similarity NPC207873
0.7269 Intermediate Similarity NPC324361
0.7269 Intermediate Similarity NPC162530
0.7265 Intermediate Similarity NPC45190
0.7265 Intermediate Similarity NPC478078
0.7265 Intermediate Similarity NPC302807
0.7264 Intermediate Similarity NPC179704
0.726 Intermediate Similarity NPC312872
0.7257 Intermediate Similarity NPC255800
0.7257 Intermediate Similarity NPC96584
0.7256 Intermediate Similarity NPC312531
0.7249 Intermediate Similarity NPC246658
0.7246 Intermediate Similarity NPC201508
0.7241 Intermediate Similarity NPC477788
0.7241 Intermediate Similarity NPC144452
0.7237 Intermediate Similarity NPC237740
0.7237 Intermediate Similarity NPC298449
0.7232 Intermediate Similarity NPC4687
0.7227 Intermediate Similarity NPC287437
0.7225 Intermediate Similarity NPC474428
0.7222 Intermediate Similarity NPC100734
0.7222 Intermediate Similarity NPC315634
0.7222 Intermediate Similarity NPC88923
0.722 Intermediate Similarity NPC148889
0.722 Intermediate Similarity NPC475844
0.7218 Intermediate Similarity NPC13603
0.7217 Intermediate Similarity NPC46561
0.7215 Intermediate Similarity NPC224928
0.7212 Intermediate Similarity NPC124086
0.7204 Intermediate Similarity NPC287588
0.7193 Intermediate Similarity NPC266931
0.7189 Intermediate Similarity NPC141915
0.7189 Intermediate Similarity NPC280964
0.7189 Intermediate Similarity NPC114335
0.7185 Intermediate Similarity NPC172222
0.7184 Intermediate Similarity NPC91868
0.7184 Intermediate Similarity NPC63971
0.7177 Intermediate Similarity NPC475301
0.7177 Intermediate Similarity NPC53255
0.7177 Intermediate Similarity NPC85879
0.7177 Intermediate Similarity NPC326930
0.7176 Intermediate Similarity NPC474904
0.7174 Intermediate Similarity NPC473513
0.7174 Intermediate Similarity NPC27041
0.7174 Intermediate Similarity NPC169402
0.7168 Intermediate Similarity NPC174672
0.7168 Intermediate Similarity NPC174758
0.7162 Intermediate Similarity NPC116238
0.7156 Intermediate Similarity NPC249583
0.7155 Intermediate Similarity NPC225279
0.7149 Intermediate Similarity NPC473506
0.7149 Intermediate Similarity NPC217554
0.7149 Intermediate Similarity NPC308137
0.7149 Intermediate Similarity NPC310211
0.7149 Intermediate Similarity NPC478083
0.7143 Intermediate Similarity NPC173080
0.7143 Intermediate Similarity NPC207686
0.7143 Intermediate Similarity NPC1608
0.7143 Intermediate Similarity NPC328928
0.7137 Intermediate Similarity NPC471304
0.7131 Intermediate Similarity NPC89549
0.7131 Intermediate Similarity NPC473833
0.7125 Intermediate Similarity NPC295228
0.7124 Intermediate Similarity NPC90185
0.7124 Intermediate Similarity NPC121069
0.7123 Intermediate Similarity NPC5167
0.7119 Intermediate Similarity NPC477787
0.7119 Intermediate Similarity NPC87152
0.7119 Intermediate Similarity NPC475631
0.7119 Intermediate Similarity NPC328186
0.7119 Intermediate Similarity NPC228377
0.7119 Intermediate Similarity NPC475600
0.7119 Intermediate Similarity NPC122968
0.7119 Intermediate Similarity NPC476110
0.7111 Intermediate Similarity NPC470164
0.7111 Intermediate Similarity NPC323345
0.7109 Intermediate Similarity NPC285941
0.7107 Intermediate Similarity NPC253482
0.7105 Intermediate Similarity NPC87413
0.7104 Intermediate Similarity NPC127085
0.7104 Intermediate Similarity NPC17677
0.7101 Intermediate Similarity NPC316841
0.7101 Intermediate Similarity NPC475303
0.7101 Intermediate Similarity NPC292416
0.7101 Intermediate Similarity NPC473689
0.7101 Intermediate Similarity NPC475596
0.7095 Intermediate Similarity NPC6786
0.709 Intermediate Similarity NPC475648
0.7089 Intermediate Similarity NPC471190
0.7089 Intermediate Similarity NPC470486
0.7089 Intermediate Similarity NPC471977

  Chemically structural similarity: II. Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC278525 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.8295 Intermediate Similarity NPD3763 Approved
0.8271 Intermediate Similarity NPD3815 Phase 1
0.8271 Intermediate Similarity NPD3816 Phase 1
0.8107 Intermediate Similarity NPD3921 Approved
0.8107 Intermediate Similarity NPD3924 Approved
0.8107 Intermediate Similarity NPD3923 Approved
0.8107 Intermediate Similarity NPD3922 Approved
0.8008 Intermediate Similarity NPD4926 Clinical (unspecified phase)
0.7686 Intermediate Similarity NPD8091 Phase 3
0.766 Intermediate Similarity NPD6790 Phase 1
0.7659 Intermediate Similarity NPD3920 Phase 2
0.7658 Intermediate Similarity NPD7571 Clinical (unspecified phase)
0.7652 Intermediate Similarity NPD5801 Clinical (unspecified phase)
0.7613 Intermediate Similarity NPD7069 Discontinued
0.7586 Intermediate Similarity NPD4885 Approved
0.7533 Intermediate Similarity NPD6242 Discontinued
0.7522 Intermediate Similarity NPD6568 Discontinued
0.7468 Intermediate Similarity NPD7885 Phase 2
0.7468 Intermediate Similarity NPD7886 Phase 2
0.7445 Intermediate Similarity NPD7395 Discontinued
0.7406 Intermediate Similarity NPD6257 Clinical (unspecified phase)
0.7378 Intermediate Similarity NPD5866 Approved
0.7353 Intermediate Similarity NPD6727 Phase 2
0.7339 Intermediate Similarity NPD7708 Approved
0.7331 Intermediate Similarity NPD6741 Clinical (unspecified phase)
0.7331 Intermediate Similarity NPD5040 Clinical (unspecified phase)
0.7325 Intermediate Similarity NPD8350 Clinical (unspecified phase)
0.7311 Intermediate Similarity NPD5805 Approved
0.7295 Intermediate Similarity NPD6525 Clinical (unspecified phase)
0.7293 Intermediate Similarity NPD4429 Discontinued
0.7285 Intermediate Similarity NPD6477 Clinical (unspecified phase)
0.7273 Intermediate Similarity NPD5483 Clinical (unspecified phase)
0.7261 Intermediate Similarity NPD1483 Discontinued
0.7257 Intermediate Similarity NPD6494 Phase 2
0.7251 Intermediate Similarity NPD7414 Clinical (unspecified phase)
0.725 Intermediate Similarity NPD2921 Clinical (unspecified phase)
0.7249 Intermediate Similarity NPD4989 Phase 2
0.7243 Intermediate Similarity NPD5488 Discontinued
0.7232 Intermediate Similarity NPD5429 Discontinued
0.723 Intermediate Similarity NPD4889 Approved
0.7222 Intermediate Similarity NPD7803 Approved
0.719 Intermediate Similarity NPD6716 Phase 1
0.7179 Intermediate Similarity NPD6247 Clinical (unspecified phase)
0.7175 Intermediate Similarity NPD5513 Phase 2
0.7174 Intermediate Similarity NPD3326 Clinical (unspecified phase)
0.7171 Intermediate Similarity NPD7862 Clinical (unspecified phase)
0.7154 Intermediate Similarity NPD5482 Discontinued
0.7149 Intermediate Similarity NPD7426 Phase 1
0.7131 Intermediate Similarity NPD5022 Discontinued
0.7131 Intermediate Similarity NPD6531 Approved
0.7131 Intermediate Similarity NPD6530 Approved
0.7131 Intermediate Similarity NPD4952 Phase 3
0.7131 Intermediate Similarity NPD8052 Clinical (unspecified phase)
0.7124 Intermediate Similarity NPD5658 Approved
0.7109 Intermediate Similarity NPD5459 Phase 2
0.7105 Intermediate Similarity NPD7927 Clinical (unspecified phase)
0.7095 Intermediate Similarity NPD1923 Clinical (unspecified phase)
0.7094 Intermediate Similarity NPD2285 Clinical (unspecified phase)
0.7083 Intermediate Similarity NPD6963 Approved
0.7083 Intermediate Similarity NPD6964 Approved
0.7082 Intermediate Similarity NPD8479 Phase 2
0.7078 Intermediate Similarity NPD7417 Discontinued
0.7069 Intermediate Similarity NPD3354 Phase 2
0.7063 Intermediate Similarity NPD6228 Discontinued
0.7049 Intermediate Similarity NPD6517 Phase 3
0.7046 Intermediate Similarity NPD3259 Approved
0.7045 Intermediate Similarity NPD4418 Discontinued
0.7042 Intermediate Similarity NPD4373 Phase 2
0.704 Intermediate Similarity NPD6219 Discontinued
0.7039 Intermediate Similarity NPD5519 Discontinued
0.7035 Intermediate Similarity NPD7010 Phase 3
0.7033 Intermediate Similarity NPD6460 Clinical (unspecified phase)
0.7032 Intermediate Similarity NPD6569 Phase 2
0.7024 Intermediate Similarity NPD7956 Approved
0.7024 Intermediate Similarity NPD7955 Approved
0.7016 Intermediate Similarity NPD7588 Discontinued
0.7009 Intermediate Similarity NPD5850 Phase 3
0.6996 Remote Similarity NPD5632 Approved
0.6992 Remote Similarity NPD7278 Phase 2
0.6992 Remote Similarity NPD6230 Discontinued
0.6992 Remote Similarity NPD7279 Phase 2
0.6991 Remote Similarity NPD3946 Clinical (unspecified phase)
0.6987 Remote Similarity NPD5914 Approved
0.6987 Remote Similarity NPD4997 Clinical (unspecified phase)
0.6984 Remote Similarity NPD7169 Suspended
0.6983 Remote Similarity NPD5891 Approved
0.6979 Remote Similarity NPD4923 Phase 1
0.6976 Remote Similarity NPD4558 Phase 2
0.6975 Remote Similarity NPD7994 Phase 2
0.6975 Remote Similarity NPD7268 Clinical (unspecified phase)
0.6974 Remote Similarity NPD7467 Discontinued
0.6974 Remote Similarity NPD4859 Phase 1
0.6973 Remote Similarity NPD3217 Phase 2
0.6964 Remote Similarity NPD4396 Clinical (unspecified phase)
0.696 Remote Similarity NPD5530 Phase 1
0.696 Remote Similarity NPD5601 Phase 2
0.6958 Remote Similarity NPD6962 Phase 2
0.6941 Remote Similarity NPD6281 Approved
0.694 Remote Similarity NPD3257 Approved
0.694 Remote Similarity NPD7538 Clinical (unspecified phase)
0.6937 Remote Similarity NPD5512 Phase 3
0.693 Remote Similarity NPD7222 Phase 2
0.6926 Remote Similarity NPD7225 Discontinued
0.6919 Remote Similarity NPD1078 Clinical (unspecified phase)
0.6914 Remote Similarity NPD3006 Discontinued
0.691 Remote Similarity NPD8149 Discontinued
0.6909 Remote Similarity NPD2334 Discontinued
0.6904 Remote Similarity NPD4845 Discontinued
0.6898 Remote Similarity NPD8016 Phase 3
0.6898 Remote Similarity NPD8017 Clinical (unspecified phase)
0.6892 Remote Similarity NPD5975 Clinical (unspecified phase)
0.6886 Remote Similarity NPD2060 Approved
0.6878 Remote Similarity NPD6160 Clinical (unspecified phase)
0.6875 Remote Similarity NPD7710 Clinical (unspecified phase)
0.6863 Remote Similarity NPD5867 Clinical (unspecified phase)
0.6852 Remote Similarity NPD3386 Phase 2
0.6847 Remote Similarity NPD1304 Clinical (unspecified phase)
0.6847 Remote Similarity NPD1038 Approved
0.6846 Remote Similarity NPD5479 Discontinued
0.6842 Remote Similarity NPD6138 Clinical (unspecified phase)
0.6838 Remote Similarity NPD3394 Approved
0.6838 Remote Similarity NPD3393 Approved
0.6838 Remote Similarity NPD3389 Approved
0.6838 Remote Similarity NPD5612 Discontinued
0.6834 Remote Similarity NPD7924 Phase 2
0.6834 Remote Similarity NPD7925 Phase 2
0.6827 Remote Similarity NPD8100 Phase 3
0.6825 Remote Similarity NPD6872 Clinical (unspecified phase)
0.6824 Remote Similarity NPD3945 Discontinued
0.6822 Remote Similarity NPD3258 Approved
0.6822 Remote Similarity NPD5450 Discontinued
0.681 Remote Similarity NPD2780 Approved
0.681 Remote Similarity NPD6567 Clinical (unspecified phase)
0.681 Remote Similarity NPD2782 Approved
0.6805 Remote Similarity NPD7555 Discontinued
0.6795 Remote Similarity NPD5417 Clinical (unspecified phase)
0.6793 Remote Similarity NPD7180 Phase 3
0.6792 Remote Similarity NPD3263 Phase 3
0.6786 Remote Similarity NPD6503 Clinical (unspecified phase)
0.6777 Remote Similarity NPD1659 Phase 1
0.6777 Remote Similarity NPD7567 Approved
0.677 Remote Similarity NPD4118 Clinical (unspecified phase)
0.6769 Remote Similarity NPD6987 Phase 1
0.6769 Remote Similarity NPD5901 Discontinued
0.6769 Remote Similarity NPD4795 Phase 2
0.6763 Remote Similarity NPD4328 Approved
0.6762 Remote Similarity NPD7558 Phase 2
0.676 Remote Similarity NPD8468 Phase 2
0.6753 Remote Similarity NPD5863 Clinical (unspecified phase)
0.6753 Remote Similarity NPD2739 Clinical (unspecified phase)
0.6749 Remote Similarity NPD1505 Phase 2
0.6746 Remote Similarity NPD8101 Phase 3
0.6745 Remote Similarity NPD2781 Approved
0.6742 Remote Similarity NPD7233 Approved
0.6742 Remote Similarity NPD7234 Approved
0.6738 Remote Similarity NPD5416 Discontinued
0.6738 Remote Similarity NPD7703 Clinical (unspecified phase)
0.6736 Remote Similarity NPD6824 Clinical (unspecified phase)
0.6735 Remote Similarity NPD7807 Clinical (unspecified phase)
0.6733 Remote Similarity NPD3328 Phase 2
0.6733 Remote Similarity NPD8358 Approved
0.6732 Remote Similarity NPD8463 Approved
0.6732 Remote Similarity NPD5532 Phase 2
0.6727 Remote Similarity NPD4375 Approved
0.6723 Remote Similarity NPD5070 Clinical (unspecified phase)
0.6723 Remote Similarity NPD5930 Phase 3
0.6723 Remote Similarity NPD4667 Clinical (unspecified phase)
0.6723 Remote Similarity NPD6140 Clinical (unspecified phase)
0.6722 Remote Similarity NPD7675 Phase 3
0.6722 Remote Similarity NPD7676 Clinical (unspecified phase)
0.6722 Remote Similarity NPD7674 Phase 3
0.6721 Remote Similarity NPD7729 Clinical (unspecified phase)
0.6713 Remote Similarity NPD5751 Clinical (unspecified phase)
0.671 Remote Similarity NPD7452 Approved
0.671 Remote Similarity NPD7453 Approved
0.6708 Remote Similarity NPD7547 Clinical (unspecified phase)
0.6707 Remote Similarity NPD7853 Phase 2
0.6706 Remote Similarity NPD8102 Discontinued
0.6696 Remote Similarity NPD4551 Phase 2
0.6696 Remote Similarity NPD2778 Approved
0.6696 Remote Similarity NPD4036 Approved
0.6696 Remote Similarity NPD3825 Phase 3
0.6696 Remote Similarity NPD4122 Approved
0.6696 Remote Similarity NPD4033 Approved
0.6696 Remote Similarity NPD4034 Approved
0.6696 Remote Similarity NPD31 Approved
0.6696 Remote Similarity NPD4037 Approved
0.6696 Remote Similarity NPD3947 Discontinued
0.6696 Remote Similarity NPD6661 Clinical (unspecified phase)
0.6696 Remote Similarity NPD4038 Approved
0.6696 Remote Similarity NPD4039 Approved
0.6696 Remote Similarity NPD32 Approved
0.6696 Remote Similarity NPD4035 Approved
0.6695 Remote Similarity NPD6298 Discontinued
0.6695 Remote Similarity NPD2433 Clinical (unspecified phase)
0.6695 Remote Similarity NPD5147 Discontinued
0.6693 Remote Similarity NPD7859 Phase 2
0.6692 Remote Similarity NPD7689 Approved
0.6682 Remote Similarity NPD1620 Clinical (unspecified phase)
0.6681 Remote Similarity NPD3795 Approved

  Bioactivity similarity: Similar Natural Products in NPASS

Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.

Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity
B: biological targets similarity
C: networks similarity
D: cell-based bioactivity similarity
E: similarity based on clinical data