Putative targets based on weak experimental activity

Plant ingredients against the target with activities between 10uM and 50uM


Ingredient ID Target (Gene Symbol) No. of Activity Values Activity Value (nM) Activity Type Activity Reference
NPC149184 PPARG 1 30000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC149184 PPARD 1 30000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC149184 PPARA 1 30000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC171736 PPARG 1 30000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC171736 PPARA 1 30000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC171736 PPARD 1 30000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC209970 ALOX15 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC209970 PPARG 1 30000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC209970 TDP1 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC209970 HSD17B10 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC216630 PPARG 1 30000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC2989 HSD17B10 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC2989 ALDH1A1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC2989 KDM4E 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC2989 PCSK7 1 24590 IC50 PMID: 21510613
NPC2989 CYP2C9 1 20000 Ki PMID: 14761192
NPC94045 ALDH1A1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC94045 CYP3A4 2 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC94045 HPGD 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC94045 SMN1;SMN2 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC94045 USP2 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC94045 KDM4E 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC94045 HSD17B10 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC94045 MAPT 2 Median: 24068.2
Range: 19952.6 to 28183.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC94045 TRPV1 3 Median: 23700
Range: 15000 to 30000
IC50 PMID: 26750258
PMID: 26750258
PMID: 26750258