Putative targets based on weak experimental activity

Plant ingredients against the target with activities between 10uM and 50uM


Ingredient ID Target (Gene Symbol) No. of Activity Values Activity Value (nM) Activity Type Activity Reference
NPC142415 ACP1 4 Median: 22050
Range: 21200 to 22900
IC50 PMID: 21453996
PMID: 21453996
PMID: 25264584
PMID: 25264584
NPC142415 PTPN6 2 Median: 22760
Range: 14190 to 31330
IC50 PMID: 18707891
PMID: 27123900
NPC156654 L3MBTL1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC156654 KDM4E 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC156654 POLB 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC238861 BLM 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC238861 KDM4E 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC238861 HSD17B10 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC238861 CASP7 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC238861 HPGD 2 Median: 24068.2
Range: 19952.6 to 28183.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC238861 CYP3A4 2 Median: 15848.9
Range: 15848.9 to 15848.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC281398 MGLL 1 48000 IC50 DOI: 10.1039/C4MD00186A
NPC281398 RECQL 2 Median: 39810.7
Range: 39810.7 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC281398 HSD17B10 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC281398 ALOX12 1 22387.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC281398 POLB 1 22387.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC281398 L3MBTL1 1 17782.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC281398 KDM4E 3 Median: 19952.6
Range: 17782.8 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC281398 TDP1 2 Median: 20085
Range: 17782.8 to 22387.2
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC281398 HPGD 2 Median: 15848.9
Range: 15848.9 to 15848.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC281398 LMNA 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC289432 THRB 1 44668.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC289432 RECQL 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC289432 TDP1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC289432 KDM4E 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC289432 BLM 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC289432 LMNA 1 22387.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC289432 HSD17B10 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC289432 TP53 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC289432 ALDH1A1 1 17782.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC289432 HPGD 1 17782.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC289432 MAPK1 2 Median: 23735.85
Range: 15848.9 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC5413 L3MBTL1 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC5413 F3 1 30000 IC50 PMID: 9834151
NPC77000 PTPRC 1 41400 IC50 PMID: 23957426
NPC77000 RECQL 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC77000 PTPN6 1 39500 IC50 PMID: 23957426
NPC77000 PTPRF 1 36900 IC50 PMID: 23957426
NPC77000 PTPN1 1 33500 IC50 PMID: 23957426
NPC77000 KMT2A 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC77000 TDP1 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC77000 NPSR1 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC77000 PTPN11 2 Median: 33840
Range: 22500 to 45180
IC50 PMID: 23957426
PMID: 23957426
NPC77000 POLB 1 22387.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC77000 KDM4E 1 17782.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC77000 L3MBTL1 1 17782.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC93241 CES1 1 26250 Ki PMID: 23286284
NPC93241 BLM 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC93241 POLB 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC142415 PTPRF 2 Median: 17055
Range: 11800 to 22310
IC50 PMID: 21453996
PMID: 27123900
NPC142415 PTPN11 1 11620 IC50 PMID: 27123900
NPC238861 TDP1 2 Median: 15954.1
Range: 14125.4 to 17782.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC238861 RECQL 2 Median: 56294.65
Range: 12589.3 to 100000
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC281398 TP53 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC289432 CYP3A4 2 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC295317 ALDH1A1 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC5413 SRD5A2 1 14000 IC50 Patent: Patent: WO2009053857 A3
NPC77000 ALDH1A1 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC84786 PNLIP 1 13000 IC50 PMID: 17521912
NPC93241 TDP1 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862