Putative targets based on weak experimental activity

Plant ingredients against the target with activities between 10uM and 50uM


Ingredient ID Target (Gene Symbol) No. of Activity Values Activity Value (nM) Activity Type Activity Reference
NPC142415 ACP1 4 Median: 22050
Range: 21200 to 22900
IC50 PMID: 21453996
PMID: 21453996
PMID: 25264584
PMID: 25264584
NPC142415 PTPN6 2 Median: 22760
Range: 14190 to 31330
IC50 PMID: 18707891
PMID: 27123900
NPC14958 ALDH1A1 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC168799 MMP13 1 29030 IC50 PMID: 22658537
NPC168799 MMP3 1 28260 IC50 PMID: 22658537
NPC168799 MMP1 2 Median: 14720
Range: 14700 to 14740
IC50 PMID: 22658537
PMID: 23353736
NPC213552 HTR7 1 47600 IC50 PMID: 16643021
NPC213552 CA4 1 44000 Ki PMID: 26498394
NPC230301 DPP4 1 28840 IC50 DOI: 10.1039/C0MD00245C
NPC230301 POLB 1 26300 IC50 PMID: 14640519
NPC264317 POLB 2 Median: 44925
Range: 43600 to 46250
IC50 PMID: 14640519
PMID: 18343122
NPC264317 GLI1 2 Median: 32000
Range: 32000 to 32000
IC50 PMID: 18842418
PMID: 19309080
NPC294902 HPGD 3 Median: 39810.7
Range: 39810.7 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC294902 ALDH1A1 2 Median: 39810.7
Range: 39810.7 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC294902 APEX1 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC294902 APP 1 32800 IC50 PMID: 22921742
NPC294902 AKR1B1 1 32000 IC50 PMID: 22236472
NPC294902 CYP3A4 2 Median: 25118.9
Range: 25118.9 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC294902 POLB 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC51700 PPARA 1 41310 EC50 PMID: 21855333
NPC51700 AKR1B1 1 41000 IC50 PMID: 21561086
NPC51700 CYP19A1 1 32000 IC50 PMID: 18192087
NPC51700 PTPN6 1 25780 IC50 PMID: 18707891
NPC51700 POLB 1 18600 IC50 PMID: 15165161
NPC51700 CTSD 1 18200 IC50 DOI: 10.1007/s00044-012-0397-z
NPC51700 SLCO1B1 1 15848.93 IC50 PMID: 23571415
NPC99240 ALDH1A1 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC99240 CYP3A4 2 Median: 15848.9
Range: 15848.9 to 15848.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC142415 PTPRF 2 Median: 17055
Range: 11800 to 22310
IC50 PMID: 21453996
PMID: 27123900
NPC142415 PTPN11 1 11620 IC50 PMID: 27123900
NPC213552 MET 1 12900 IC50 PMID: 27258622
NPC264317 AKR1B1 1 11000 IC50 PMID: 21561086
NPC294902 THRB 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC294902 CA4 1 10100 Ki PMID: 20185318
NPC51700 SLCO1B3 1 11481.54 IC50 PMID: 23571415
NPC99240 TP53 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC99240 HPGD 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862