Putative targets based on weak experimental activity

Plant ingredients against the target with activities between 10uM and 50uM


Ingredient ID Target (Gene Symbol) No. of Activity Values Activity Value (nM) Activity Type Activity Reference
NPC103342 KDM4E 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC103342 CYP3A4 1 36200 IC50 PMID: 15270556
NPC116775 BCHE 1 43100 Ki PMID: 19879672
NPC116775 ALDH1A1 2 Median: 35716.75
Range: 31622.8 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC116775 HPGD 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC116775 CDK6 2 Median: 22000
Range: 22000 to 22000
IC50 PMID: 15689157
DOI: 10.1007/s00044-009-9233-5
NPC116775 GLO1 1 20600 IC50 PMID: 18258440
NPC116775 KDM4E 2 Median: 27829.8
Range: 15848.9 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC116775 HSD17B10 2 Median: 15848.9
Range: 15848.9 to 15848.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC116775 BACE1 1 14700 IC50 DOI: 10.1007/s00044-012-0353-y
NPC133671 P4HB 1 19020 AC50 PubChem BioAssay data set
CHEMBL1201862
NPC169749 DPP4 1 37150 IC50 DOI: 10.1039/C0MD00245C
NPC169749 ALPL 1 33200 IC50 PubChem BioAssay data set
CHEMBL1201862
NPC169749 ALPPL2 1 32300 EC50 PubChem BioAssay data set
CHEMBL1201862
NPC169749 KMT2A 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC169749 AMY1A;AMY1B;AMY1C 1 30200 IC50 PMID: 18507367
NPC169749 AKR1B1 1 29000 IC50 PMID: 18165015
NPC169749 CD38 1 24800 IC50 PMID: 21641214
NPC169749 DAPK1 1 23000 IC50 PMID: 26322379
NPC169749 ABCC2 1 22000 IC50 PMID: 19725578
NPC169749 ABCC1 1 20000 IC50 PMID: 19725578
NPC169749 CYP2D6 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC169749 APOBEC3A 1 17500 IC50 PubChem BioAssay data set
CHEMBL1201862
NPC169749 MTOR 2 Median: 19881.25
Range: 16481.6 to 23280.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC169749 BLM 3 Median: 14125.4
Range: 14125.4 to 14125.4
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC169749 ALOX12 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC176740 MAPT 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC176740 EPHX2 1 24300 IC50 PMID: 24679441
NPC176740 KDM4E 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC179950 EPHX2 1 28430 IC50 PMID: 24679441
NPC179950 XDH 1 26310 IC50 PMID: 12444671
NPC179950 MAPT 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC181465 XDH 1 14800 IC50 PMID: 9461655
NPC20791 PMP22 1 47754.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 THRB 1 44668.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 GALK1 1 42128.5 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 CDK2 1 40000 IC50 PMID: 17178224
NPC20791 CD38 1 37900 IC50 PMID: 21641214
NPC20791 SORD 2 Median: 106300
Range: 35600 to 177000
IC50 PMID: 8893834
PMID: 12672241
NPC20791 SMN1;SMN2 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 EPHX2 1 33540 IC50 PMID: 24679441
NPC20791 DPP4 2 Median: 81365
Range: 32730 to 130000
IC50 PMID: 18650094
DOI: 10.1039/C0MD00245C
NPC20791 MAPK1 2 Median: 35716.75
Range: 31622.8 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 ADORA3 1 30000 Ki PMID: 8576921
NPC20791 PTGS2 1 28600 IC50 PMID: 17378609
NPC20791 BLM 3 Median: 28183.8
Range: 28183.8 to 28183.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 TDP1 2 Median: 26651.35
Range: 25118.9 to 28183.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 ALDH1A1 6 Median: 37646
Range: 25118.9 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 CDK6 2 Median: 25000
Range: 25000 to 25000
IC50 PMID: 15689157
DOI: 10.1007/s00044-009-9233-5
NPC20791 PTPN1 2 Median: 23300
Range: 23300 to 23300
IC50 PMID: 12419367
PMID: 19297174
NPC20791 KMT2A 1 22387.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 AMY1A;AMY1B;AMY1C 1 21400 IC50 PMID: 18507367
NPC20791 SYK 1 20000 IC50 PMID: 22257213
NPC20791 HPGD 2 Median: 21169.9
Range: 19952.6 to 22387.2
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 APEX1 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 CYP2D6 1 18800 IC50 PMID: 22328583
NPC20791 USP2 2 Median: 25057.75
Range: 18492.7 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 GPR35 1 15400 IC50 PMID: 24900447
NPC20791 APP 1 15300 IC50 PMID: 26719209
NPC231772 MAPK1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC231772 TDP1 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC231772 TP53 2 Median: 28370.85
Range: 25118.9 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC240431 EPHX2 1 17230 IC50 PMID: 24679441
NPC305016 CYP3A4 1 23200 Ki PMID: 16248836
NPC59951 CYP2D6 1 45500 IC50 PMID: 15270556
NPC59951 CYP3A4 1 21800 IC50 PMID: 15270556
NPC103342 RECQL 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC116775 MAPT 2 Median: 14219.1
Range: 12589.3 to 15848.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC169749 HSP90AB1 1 13500 IC50 PMID: 24548207
NPC179950 ALPL 1 14000 IC50 PubChem BioAssay data set
CHEMBL1201862
NPC179950 KDM4E 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 LMNA 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 PIK3CG 1 13790 IC50 PMID: 25050878
NPC20791 PREP 1 13000 IC50 PMID: 18650094
NPC20791 LCK 2 Median: 13000
Range: 13000 to 13000
IC50 PMID: 1995903
PMID: 16441060
NPC20791 CALM1;CALM2;CALM3 1 12970 IC50 PMID: 21129983
NPC20791 PLAU 1 12100 IC50 PMID: 24610996
NPC20791 CA5B 1 11900 Ki PMID: 20185318
NPC20791 CYP2C19 1 10500 IC50 PMID: 22328583
NPC20791 MMP12 1 10230 IC50 PMID: 22658537
NPC20791 HIF1AN 1 10200 IC50 PMID: 19822432
NPC20791 CYP2C9 1 10200 IC50 PMID: 22328583
NPC231772 LMNA 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC231772 SMN1;SMN2 2 Median: 19622.15
Range: 14125.4 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC231772 USP2 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC231772 CYP2D6 1 12589.25 AC50 PubChem BioAssay data set
CHEMBL1201862