Putative targets based on weak experimental activity

Plant ingredients against the target with activities between 10uM and 50uM


Ingredient ID Target (Gene Symbol) No. of Activity Values Activity Value (nM) Activity Type Activity Reference
NPC141765 PPARD 1 18110 EC50 PMID: 27450788
NPC141765 PTPN1 1 15010 IC50 PMID: 24224843
NPC183950 POLB 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC183950 ALDH1A1 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC183950 MAPT 1 22387.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC183950 KMT2A 1 17782.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC203891 XDH 1 36500 IC50 PMID: 10425142
NPC203891 PKM 2 Median: 25118.9
Range: 25118.9 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC203891 MAPT 1 22387.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC230301 DPP4 1 28840 IC50 DOI: 10.1039/C0MD00245C
NPC230301 POLB 1 26300 IC50 PMID: 14640519
NPC231772 MAPK1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC231772 TDP1 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC231772 TP53 2 Median: 28370.85
Range: 25118.9 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC243728 POLB 1 26500 IC50 PMID: 15165161
NPC247553 GLA 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC247553 GAA 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC247553 ALDH1A1 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC247553 HPGD 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC247553 HSD17B10 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC247553 AKR1B1 1 22900 IC50 PMID: 20805028
NPC247553 CASP1 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC247553 CASP7 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC247553 KDM4E 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 GALK1 1 47269 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 THRB 1 44668.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 TSHR 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 CYP2C9 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 CYP2D6 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 GAA 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 DAPK1 1 21000 IC50 PMID: 26322379
NPC279121 CDK2 1 20000 IC50 PMID: 17178224
NPC279121 TDP1 2 Median: 29881.65
Range: 19952.6 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC279121 ABCB1 1 19600 IC50 PMID: 15240100
NPC279121 GPR35 1 18600 IC50 PMID: 24900447
NPC279121 AMY1A;AMY1B;AMY1C 1 18400 IC50 PMID: 18507367
NPC279121 MMP3 1 16200 IC50 PMID: 22658537
NPC279121 CYP2C19 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 BLM 2 Median: 17900.75
Range: 15848.9 to 19952.6
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC434 ALDH1A1 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC434 HSD17B10 2 Median: 35716.75
Range: 31622.8 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC434 CYP3A4 2 Median: 25118.9
Range: 25118.9 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC49074 PTGS1 1 36000 IC50 PMID: 16038536
NPC50898 APEX1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC50898 THRB 2 Median: 44964.7
Range: 39810.7 to 50118.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC50898 BACE1 2 Median: 38500
Range: 38500 to 38500
IC50 PMID: 22243648
DOI: 10.1007/s00044-012-0353-y
NPC50898 BCHE 1 37400 Ki PMID: 19879672
NPC50898 HBB 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC50898 HSD17B10 2 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC50898 DAPK1 1 31000 IC50 PMID: 26322379
NPC50898 NPSR1 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC50898 HPGD 3 Median: 28183.8
Range: 22387.2 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC50898 NFKB1 2 Median: 19952.6
Range: 19952.6 to 19952.6
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC50898 MAPK1 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC76336 GLA 2 Median: 40074.85
Range: 35481.3 to 44668.4
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC76336 GAA 2 Median: 40074.85
Range: 35481.3 to 44668.4
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC76336 RECQL 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC76336 CA13 1 17800 Ki PMID: 22892213
NPC231772 LMNA 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC231772 SMN1;SMN2 2 Median: 19622.15
Range: 14125.4 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC231772 USP2 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC231772 CYP2D6 1 12589.25 AC50 PubChem BioAssay data set
CHEMBL1201862
NPC279121 MAPT 3 Median: 12589.3
Range: 12589.3 to 17782.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC279121 SYK 1 12000 IC50 PMID: 22257213
NPC279121 HPGD 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 MMP13 1 10050 IC50 PMID: 22658537
NPC29883 CA2 2 Median: 10600
Range: 10600 to 10600
Ki PMID: 18501600
PMID: 18579385
NPC434 HPGD 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC50898 SMN1;SMN2 5 Median: 22387.2
Range: 14125.4 to 35481.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC50898 MAOB 1 12800 IC50 PMID: 20045650
NPC50898 CYP2D6 2 Median: 26200
Range: 12589.3 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC50898 GMNN 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC50898 LMNA 2 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC50898 AKR1B1 1 11900 IC50 PMID: 26529431
NPC50898 KDM4E 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC76336 HIF1A 2 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC76336 CA1 1 10560 Ki PMID: 22892213