Putative targets based on weak experimental activity

Plant ingredients against the target with activities between 10uM and 50uM


Ingredient ID Target (Gene Symbol) No. of Activity Values Activity Value (nM) Activity Type Activity Reference
NPC219876 HSD17B10 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC219876 PTGS1 2 Median: 58350
Range: 36700 to 80000
IC50 PMID: 11858749
PMID: 16038536
NPC219876 SMN1;SMN2 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC219876 NPSR1 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC219876 BLM 2 Median: 28183.8
Range: 28183.8 to 28183.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC219876 ALDH1A1 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC219876 RECQL 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC219876 MAPT 2 Median: 19952.6
Range: 19952.6 to 19952.6
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC219876 APEX1 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 GALK1 1 47269 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 THRB 1 44668.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 TSHR 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 CYP2C9 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 CYP2D6 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 GAA 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 DAPK1 1 21000 IC50 PMID: 26322379
NPC279121 CDK2 1 20000 IC50 PMID: 17178224
NPC279121 TDP1 2 Median: 29881.65
Range: 19952.6 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC279121 ABCB1 1 19600 IC50 PMID: 15240100
NPC279121 GPR35 1 18600 IC50 PMID: 24900447
NPC279121 AMY1A;AMY1B;AMY1C 1 18400 IC50 PMID: 18507367
NPC279121 MMP3 1 16200 IC50 PMID: 22658537
NPC279121 CYP2C19 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 BLM 2 Median: 17900.75
Range: 15848.9 to 19952.6
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC289774 TDP1 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC49074 PTGS1 1 36000 IC50 PMID: 16038536
NPC50898 APEX1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC50898 THRB 2 Median: 44964.7
Range: 39810.7 to 50118.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC50898 BACE1 2 Median: 38500
Range: 38500 to 38500
IC50 PMID: 22243648
DOI: 10.1007/s00044-012-0353-y
NPC50898 BCHE 1 37400 Ki PMID: 19879672
NPC50898 HBB 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC50898 HSD17B10 2 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC50898 DAPK1 1 31000 IC50 PMID: 26322379
NPC50898 NPSR1 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC50898 HPGD 3 Median: 28183.8
Range: 22387.2 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC50898 NFKB1 2 Median: 19952.6
Range: 19952.6 to 19952.6
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC50898 MAPK1 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC53545 L3MBTL1 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC219876 KDM4E 2 Median: 19622.15
Range: 14125.4 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC219876 POLB 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 MAPT 3 Median: 12589.3
Range: 12589.3 to 17782.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC279121 SYK 1 12000 IC50 PMID: 22257213
NPC279121 HPGD 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279121 MMP13 1 10050 IC50 PMID: 22658537
NPC50898 SMN1;SMN2 5 Median: 22387.2
Range: 14125.4 to 35481.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC50898 MAOB 1 12800 IC50 PMID: 20045650
NPC50898 CYP2D6 2 Median: 26200
Range: 12589.3 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC50898 GMNN 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC50898 LMNA 2 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC50898 AKR1B1 1 11900 IC50 PMID: 26529431
NPC50898 KDM4E 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862