Records matched to the searched keyword "n.a."

Matched Space Investigations


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Study IDs Study Titles Investigation Categories Studied Biophysical Phenomena Associated Disease conditions Studied Biological Phenomena
SLID-001 The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Saliva; Urine; Blood; Fecal; Microbiota;
●n.a.
 ●Aging
●Neuro-ocular syndrome
●Immune system dysregulation
●Stress
 ●Omics - Transcriptome ---> Blood
●Omics - Transcriptome ---> Leukocytes
●Omics - Epigenome ---> Leukocytes
●Omics - Proteome ---> Blood
●Omics - Proteome ---> Urine
●Omics - Metabolome ---> Blood
●Omics - Metabolome ---> Fecal
●Omics - Metabolome ---> Urine
●Omics - Microbiome ---> Fecal
●Omics - Microbiome ---> Skin
●Cardiovascular and Immune System - Blood components ---> Blood cells
●Cardiovascular and Immune System - Blood components ---> Oxidative status
●Cardiovascular and Immune System - Immune function ---> Cytokine concentration
●Cardiovascular and Immune System - Immune function ---> Leukocytes
●Omics - DNA damage ---> Telomere length dynamics
●Omics - DNA damage ---> Omics - DNA damage responses
●Nervous and regulatory systems - Cognitive performance
●Nervous and regulatory systems - Eye properties ---> Intraocular pressure
●Cardiovascular and Immune System - Vessel properties ---> Carotid intima-media layer
SLID-002 Eye-Head Coordination in 31 Space Shuttle Astronauts during Visual Target Acquisition Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Behavior;
●n.a.
 ●Visuo-motor disorder
 ●Nervous and regulatory systems - Neuromotor control ---> Eye-head coordination changes
SLID-003 Short-duration spaceflight does not prolong QTc intervals in male astronauts Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Heart;
●Statistical physics of fluctuation system - Heartbeat fluctuation
 ●Long QT syndrome
 ●Cardiovascular and Immune System - Heart rhythm ---> QTc intervals
●Cardiovascular and Immune System - Heart rhythm ---> PR intervals
●Cardiovascular and Immune System - Heart rhythm ---> RR intervals
SLID-004 Effects of 17-day spaceflight on knee extensor muscle function and size Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Muscle;
●n.a.
 ●Muscle atrophy
 ●Musculoskeletal system - Muscle properties ---> Muscle force
●Musculoskeletal system - Muscle properties ---> Muscle cross-sectional area
SLID-005 Microbiological status of cosmonauts during orbital spaceflights on Salyut and Mir orbital stations Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Urine; Microbiota;
●n.a.
 ●Pathogen antibiotic resistance
 ●Omics - Microbiome ---> Urine
●Omics - Microbiome ---> Skin
●Omics - Microbiome ---> Mouth
●Omics - Microbiome ---> Throat
●Omics - Microbiome ---> Conventional pathogens
●Omics - Microbiome ---> Antibiotic sensitivity
SLID-006 Protein expression changes caused by spaceflight as measured for 18 Russian cosmonauts Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Blood;
●n.a.
 ●n.a.
 ●Cardiovascular and Immune System - Blood components ---> Blood proteins
SLID-007 Stress Related Shift Toward Inflammaging in Cosmonauts After Long-Duration Space Flight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Lymphocytes;
●n.a.
 ●Stress
●Immune system dysregulation
 ●Nervous and regulatory systems - Stress analysis ---> Stress markers
●Cardiovascular and Immune System - Immune function ---> Leukocyte number
●Cardiovascular and Immune System - Immune function ---> Cytokine response
SLID-008 Temporal Telomere and DNA Damage Responses in the Space Radiation Environment Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Urine; Blood;
●n.a.
 ●Aging
 ●Omics - DNA damage ---> Telomere length dynamics
●Omics - DNA damage ---> Telomere elongation
●Omics - DNA damage ---> Omics - DNA damage responses
SLID-009 Cardiovascular autonomic control after short-duration spaceflights Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Heart; Vessel;
●Statistical physics of fluctuation system - Heartbeat fluctuation
●Fluid dynamics - Hemodynamics
 ●Cardiac rhythm disturbances
●Orthostatic intolerance
 ●Cardiovascular and Immune System - Heart rhythm ---> Heart rate variability
●Cardiovascular and Immune System - Vessel properties ---> Blood pressure variability
●Cardiovascular and Immune System - Vessel properties ---> Baroreflex sensitivity
●Nervous and regulatory systems - Vegetative nervous system function ---> Cardiovascular autonomic control
SLID-010 Impairments of manual tracking performance during spaceflight: more converging evidence from a 20-day space mission Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Behavior;
●n.a.
 ●Visuo-motor disorder
●Mood impairment
 ●Nervous and regulatory systems - Neuromotor control ---> Manual tracking performance
●Nervous and regulatory systems - Psychology ---> Mood
SLID-011 Ocular Counter Rolling in Astronauts After Short- and Long-Duration Spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Behavior;
●n.a.
 ●Visuo-motor disorder
●Neurovestibular decline
 ●Nervous and regulatory systems - Neuro-sensory function ---> Ocular counter-rolling
●Nervous and regulatory systems - Neuro-sensory function ---> Gravity sensing
●Nervous and regulatory systems - Neuro-sensory function ---> Microgravity adaptation
SLID-012 Mechanism of spaceflight-induced changes in left ventricular mass Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Heart;
●Fluid dynamics - Hemodynamics
 ●Brain damage
 ●Nervous and regulatory systems - Brain structure ---> Left ventricular mass
●Nervous and regulatory systems - Brain structure ---> Left ventricular end-diastolic volume
●Nervous and regulatory systems - Brain structure ---> Left ventricular wall thickness
SLID-013 Immune system dysregulation occurs during short duration spaceflight on board the space shuttle Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Blood;
●n.a.
 ●Immune system dysregulation
 ●Cardiovascular and Immune System - Immune function ---> Leukocytes distribution
●Cardiovascular and Immune System - Immune function ---> Leukocytes population
●Cardiovascular and Immune System - Immune function ---> Leukocytes function
SLID-014 Latent virus reactivation in astronauts on the international space station Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Urine; Saliva; Blood;
●n.a.
 ●Latent viral reactivation
 ●Cardiovascular and Immune System - Immune function ---> Latent viral reactivation
SLID-015 Alterations in adaptive immunity persist during long-duration spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Blood;
●n.a.
 ●Immune system dysregulation
 ●Cardiovascular and Immune System - Immune function ---> Lymphocytes population
●Cardiovascular and Immune System - Immune function ---> Lymphocytes function
SLID-016 Latent viral reactivation is associated with changes in plasma antimicrobial protein concentrations during long-duration spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Saliva; Blood; Urine;
●n.a.
 ●Immune system dysregulation
 ●Cardiovascular and Immune System - Immune function ---> Latent viral reactivation
●Cardiovascular and Immune System - Immune function ---> Plasma antimicrobial protein concentrations
SLID-017 Optic Nerve Length before and after Spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Nerve; Behavior;
●n.a.
 ●Neuro-ocular syndrome
 ●Nervous and regulatory systems - Neuro-sensory function ---> Optic nerve length increasement
SLID-018 Plasma cytokine concentrations indicate that in vivo hormonal regulation of immunity is altered during long-duration spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Blood;
●n.a.
 ●Immune system dysregulation
 ●Cardiovascular and Immune System - Immune function ---> Cytokine concentration
●Nervous and regulatory systems - Endocrine function ---> Hormonal regulation
SLID-019 Spaceflight modulates gene expression in the whole blood of astronauts Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Blood;
●n.a.
 ●n.a.
 ●Omics - Transcriptome ---> Blood
●Other profiles - Molecular pathway
SLID-020 Intrinsic cardiovascular autonomic regulatory system of astronauts exposed long-term to microgravity in space: observational study Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Heart;
●Statistical physics of fluctuation system - Heartbeat fluctuation
 ●Cardiac rhythm disturbances
 ●Cardiovascular and Immune System - Heart rhythm ---> Heart rate variability
●Cardiovascular and Immune System - Heart rhythm ---> Power-law scaling β
●Cardiovascular and Immune System - Heart rhythm ---> Intrinsic autonomic regulatory system
●Cardiovascular and Immune System - Circadian rhythm
SLID-021 Effect of short- and long-duration spaceflight on QTc intervals in healthy astronauts Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Vessel; Heart;
●Statistical physics of fluctuation system - Heartbeat fluctuation
 ●Cardiac rhythm disturbances
 ●Cardiovascular and Immune System - Heart rhythm ---> QTc intervals
●Cardiovascular and Immune System - Heart rhythm ---> PR intervals
●Cardiovascular and Immune System - Heart rhythm ---> RR intervals
●Cardiovascular and Immune System - Blood components ---> Serum electrolytes
SLID-022 Bisphosphonates as a supplement to exercise to protect bone during long-duration spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Urine; Blood;
●n.a.
 ●Bone loss
 ●Musculoskeletal system - Bone properties ---> Bone mineral density
●Musculoskeletal system - Bone properties ---> Bone metabolism
●Digestive and Excretory System - Urine components ---> Urine Ca
●Other profiles - Medication use ---> Bisphosphonates
●Other profiles - Medication use ---> Alendronate
●Other profiles - Medication use ---> Exercise
SLID-023 Anti-aging effects of long-term space missions, estimated by heart rate variability Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Heart;
●Statistical physics of fluctuation system - Heartbeat fluctuation
●Magnetosphere
 ●Aging
 ●Cardiovascular and Immune System - Heart rhythm ---> Heart rate variability
●Other profiles - Magnetosphere
●Cardiovascular and Immune System - Circadian rhythm
SLID-024 Measurements of jugular, portal, femoral, and calf vein cross-sectional area for the assessment of venous blood redistribution with long duration spaceflight (Vessel Imaging Experiment) Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Vessel;
●Fluid dynamics - Hemodynamics
 ●n.a.
 ●Cardiovascular and Immune System - Vessel properties ---> Vein volume
●Cardiovascular and Immune System - Vessel properties ---> Vessel cross-sectional area
●Cardiovascular and Immune System - Vessel properties ---> Vessel 3D reconstruction
●Cardiovascular and Immune System - Vessel properties ---> Venous blood redistribution
●Cardiovascular and Immune System - Vessel properties ---> Venous blood velocity
SLID-025 NK cell function is impaired during long-duration spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Blood;
●n.a.
 ●Immune system dysregulation
 ●Cardiovascular and Immune System - Immune function ---> Natural killer cell impairment
SLID-026 Modification of unilateral otolith responses following spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Behavior;
●Inertial forces - Otolith system
 ●Neurovestibular decline
 ●Nervous and regulatory systems - Neuro-sensory function ---> Unilateral otolith responses
SLID-027 Telomere Length Dynamics and DNA Damage Responses Associated with Long-Duration Spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Blood; Urine;
●n.a.
 ●Aging
 ●Omics - DNA damage ---> Telomere length dynamics
●Omics - DNA damage ---> Telomere elongation
●Omics - DNA damage ---> Omics - DNA damage responses
SLID-028 Reduction in proximal femoral strength due to long-duration spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Bone;
●n.a.
 ●Bone loss
 ●Musculoskeletal system - Bone properties ---> Proximal femoral strength
SLID-029 Flexor bias of joint position in humans during spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Joint;
●n.a.
 ●Joint injury
 ●Musculoskeletal system - Joint mobility ---> Elbow extension
●Musculoskeletal system - Joint mobility ---> Elbow flexion
●Musculoskeletal system - Joint mobility ---> Ankle plantarflexion
●Musculoskeletal system - Joint mobility ---> Ankle dorsiflexion
●Musculoskeletal system - Joint mobility ---> Elbow joint angles
●Musculoskeletal system - Joint mobility ---> Flexor bias
SLID-030 Plasticity of the human IgM repertoire in response to long-term spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Blood; Saliva;
●n.a.
 ●Immune system dysregulation
 ●Cardiovascular and Immune System - Immune function ---> Antibody function
●Cardiovascular and Immune System - Immune function ---> IgM repertoire
●Cardiovascular and Immune System - Immune function ---> Stress response
SLID-031 Cortical reorganization in an astronaut's brain after long-duration spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Brain; Behavior;
●n.a.
 ●Sensorimotor decline
 ●Nervous and regulatory systems - Neuromotor control ---> Motor cortex-cerebellum functional connectivity
●Nervous and regulatory systems - Neuromotor control ---> Supplementary motor areas
●Nervous and regulatory systems - Neural properties ---> Cortical reorganization
SLID-032 Brain Tissue-Volume Changes in Cosmonauts Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Brain;
●Fluid dynamics - Hemodynamics
 ●Brain damage
 ●Nervous and regulatory systems - Brain structure ---> Gray matter volume
●Nervous and regulatory systems - Brain structure ---> White matter volume
●Nervous and regulatory systems - Brain structure ---> Cerebrospinal fluid space
SLID-033 Spaceflight-Associated Brain White Matter Microstructural Changes and Intracranial Fluid Redistribution Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Brain;
●Fluid dynamics - Hemodynamics
 ●Brain damage
●Aging
 ●Nervous and regulatory systems - Brain structure ---> Intracranial extracellular free water shifts
●Nervous and regulatory systems - Brain structure ---> Transient balance declines
●Nervous and regulatory systems - Brain structure ---> White matter microstructural changes
SLID-034 Lumbopelvic Muscle Changes Following Long-Duration Spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Muscle;
●n.a.
 ●Muscle atrophy
 ●Musculoskeletal system - Muscle properties ---> Lumbar musculature attenuation
SLID-035 Alterations in hematologic indices during long-duration spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Blood;
●n.a.
 ●Anemia
 ●Cardiovascular and Immune System - Blood components ---> Red blood cell indices
●Cardiovascular and Immune System - Blood components ---> Hemoglobin content
SLID-036 Effects of 17-day spaceflight on electrically evoked torque and cross-sectional area of the human triceps surae Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Muscle;
●n.a.
 ●Muscle atrophy
 ●Musculoskeletal system - Muscle properties ---> Muscle plus bone cross-sectional area
●Musculoskeletal system - Muscle properties ---> Twitch kinetics
SLID-037 Long-term changes in the density and structure of the human hip and spine after long-duration spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Bone;
●n.a.
 ●Bone loss
 ●Musculoskeletal system - Bone properties ---> Bone mineral density
●Musculoskeletal system - Bone properties ---> Bone mineral content
●Musculoskeletal system - Bone properties ---> Vertebral cross-sectional area
SLID-038 Increased core body temperature in astronauts during long-duration space missions Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Blood;
●Fluid dynamics - Hemodynamics
●Heat conduction - Body temperature
 ●Fever
 ●Nervous and regulatory systems - Body temperature ---> Core body temperature
●Nervous and regulatory systems - Body temperature ---> Thermoregulation
●Cardiovascular and Immune System - Immune function ---> Interleukin-1 receptor antagonist protein
●Nervous and regulatory systems - Cognitive performance
SLID-039 The effects of spaceflight on mammary metabolism in pregnant rats Investigated Organism: Rattus norvegicus;
Studied Organism Strains: SpragueDawley-derived;
Organism Common Name: Rat;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Mammary gland;
●n.a.
 ●Development impairment
 ●Nervous and regulatory systems - Endocrine function ---> Mammary metabolism
SLID-040 Loss of T cell precursors after spaceflight and exposure to vector-averaged gravity Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6 (B6)mice;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone marrow; Spleen; Thymus; Leukocytes;
●n.a.
 ●Immune system dysregulation
 ●Cardiovascular and Immune System - Immune function ---> T cell development
●Environment - Simulated microgravity
SLID-041 Effects of spaceflight on the murine mandible: Possible factors mediating skeletal changes in non-weight bearing bones of the head Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone;
●n.a.
 ●Bone loss
 ●Musculoskeletal system - Bone properties ---> Skull remodeling
●Musculoskeletal system - Bone properties ---> Bone volume
●Musculoskeletal system - Bone properties ---> Mineral density
●Musculoskeletal system - Bone properties ---> Mineral content
SLID-042 Effects of Spaceflight on Bone Microarchitecture in the Axial and Appendicular Skeleton in Growing Ovariectomized Rats Investigated Organism: Rattus norvegicus;
Studied Organism Strains: Fischer 344;
Organism Common Name: Rat;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone;
●n.a.
 ●Bone loss
 ●Musculoskeletal system - Bone properties ---> Bone mass
●Musculoskeletal system - Bone properties ---> Bone density
●Musculoskeletal system - Bone properties ---> Bone structure
●Nervous and regulatory systems - Endocrine function ---> Ovarian hormone insufficiency
SLID-043 Spaceflight Activates Lipotoxic Pathways in Mouse Liver Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Liver;
●n.a.
 ●Nonalcoholic fatty liver
 ●Omics - Transcriptome
●Omics - Metabolome
●Digestive and Excretory System - Liver function ---> Lipids metabolism dysfunction
SLID-044 Spaceflight-induced vertebral bone loss in ovariectomized rats is associated with increased bone marrow adiposity and no change in bone formation Investigated Organism: Rattus norvegicus;
Studied Organism Strains: Fischer 344;
Organism Common Name: Rat;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone;
●n.a.
 ●Bone loss
 ●Musculoskeletal system - Bone properties ---> Bone marrow adiposity
●Musculoskeletal system - Bone properties ---> Bone formation
●Musculoskeletal system - Bone properties ---> Bone loss
SLID-045 Effects of spaceflight on the immunoglobulin repertoire of unimmunized C57BL/6 mice Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6Tac;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Liver;
●n.a.
 ●Bone loss
 ●Nervous and regulatory systems - Brain properties ---> Structure
●Nervous and regulatory systems - Brain properties ---> Protein localization
SLID-046 Responses to spaceflight of mouse mandibular bone and teeth Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone; Teeth;
●n.a.
 ●Bone loss
●Development impairment
 ●Musculoskeletal system - Teeth properties ---> Teeth proteins
●Musculoskeletal system - Teeth properties ---> Teeth development retardation
●Musculoskeletal system - Teeth properties ---> Teeth mineralization
●Musculoskeletal system - Bone properties ---> Bone structure
SLID-047 Reproducible changes in the gut microbiome suggest a shift in microbial and host metabolism during spaceflight Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Liver; Microbiota;
●n.a.
 ●Gastrointestinal homeostasis
 ●Omics - Transcriptome ---> Liver
●Omics - Microbiome
SLID-048 Multiscale effects of spaceflight on murine tendon and bone Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Tendon; Bone;
●n.a.
 ●Bone loss
●Tendon decline
 ●Musculoskeletal system - Bone properties ---> Bone composition
●Musculoskeletal system - Bone properties ---> Bone structure
●Musculoskeletal system - Bone properties ---> Bone mechanics
●Musculoskeletal system - Tendon properties ---> Fibril diameter
SLID-049 Multi-omics analysis of multiple missions to space reveal a theme of lipid dysregulation in mouse liver Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Liver;
●n.a.
 ●Nonalcoholic fatty liver
 ●Omics - Multiomics analysis
●Digestive and Excretory System - Liver function ---> Lipid dysregulation
SLID-050 Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Thymus;
●n.a.
 ●Immune system dysregulation
 ●Cardiovascular and Immune System - Immune function ---> Thymic size
●Omics - Transcriptome ---> Thymus
●Environment - Artificial gravity
●n.a.
SLID-051 Effects of spaceflight on rat humerus geometry, biomechanics, and biochemistry Investigated Organism: Rattus norvegicus;
Studied Organism Strains: Wistar;
Organism Common Name: Rat;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone;
●n.a.
 ●Bone loss
 ●Musculoskeletal system - Bone properties ---> Bone structure
●Musculoskeletal system - Bone properties ---> Bone biomechanical property
●Musculoskeletal system - Bone properties ---> Bone components
SLID-052 Protein and collagen content of rat skeletal muscle following space flight Investigated Organism: Rattus norvegicus;
Studied Organism Strains: SpragueDawley-derived;
Organism Common Name: Rat;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Muscle;
●n.a.
 ●Muscle atrophy
 ●Musculoskeletal system - Muscle properties ---> Muscle composition
SLID-053 Fragility and composition of growing rat bone after one week in spaceflight Investigated Organism: Rattus norvegicus;
Studied Organism Strains: Pathogen-free albino male;
Organism Common Name: Rat;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone;
●n.a.
 ●Bone loss
 ●Musculoskeletal system - Bone properties ---> Bone metabolism
●Musculoskeletal system - Bone properties ---> Osteocalcin content
SLID-054 Effect of space flight on cytokine production and other immunologic parameters of rhesus monkeys Investigated Organism: Macaca mulatta;
Organism Common Name: Rhesus monkey;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone marrow; Leukocytes;
●n.a.
 ●Immune system dysregulation
 ●Cardiovascular and Immune System - Immune function ---> Cytokine production
●Cardiovascular and Immune System - Immune function ---> Marrow cell responsiveness
SLID-055 Spaceflight Downregulates Antioxidant Defense Systems in Rat Liver Investigated Organism: Rattus norvegicus;
Studied Organism Strains: SpragueDawley-derived;
Organism Common Name: Rat;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Liver;
●n.a.
 ●Oxidative damage
 ●Digestive and Excretory System - Liver function ---> Antioxidant defense
●Digestive and Excretory System - Liver function ---> Enzyme activity
SLID-056 Sustained microgravity reduces intrinsic wound healing and growth factor responses in the rat Investigated Organism: Rattus norvegicus;
Studied Organism Strains: Fisher 344;
Organism Common Name: Rat;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Connective tissue;
●n.a.
 ●Wound healing
 ●Development and Reproduction - Regeneration ---> Wound healing
●Other profiles - Medication use ---> Growth factor
SLID-057 Effects of spaceflight and PEG-IL-2 on rat physiological and immunological responses Investigated Organism: Rattus norvegicus;
Studied Organism Strains: SpragueDawley-derived;
Organism Common Name: Rat;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Brain; Heart; Kidney; Liver; Lungs; Trachea; Spleen; Thymus; Bone; Blood; Whole animal;
●n.a.
 ●Bone loss
●Immune system dysregulation
 ●Other profiles - Organ morphology ---> Brain
●Other profiles - Organ morphology ---> Heart
●Other profiles - Organ morphology ---> Kidneys
●Other profiles - Organ morphology ---> Liver
●Other profiles - Organ morphology ---> Lungs
●Other profiles - Organ morphology ---> Trachea
●Other profiles - Organ morphology ---> Spleen
●Other profiles - Organ morphology ---> Thymus
●Cardiovascular and Immune System - Immune function ---> Blood cell differentials
●Cardiovascular and Immune System - Immune function ---> Colony-forming units
●Cardiovascular and Immune System - Immune function ---> Lymphocyte mitogenic
●Cardiovascular and Immune System - Immune function ---> Superantigenic responses
●Cardiovascular and Immune System - Immune function ---> Interferon-gamma responses
●Cardiovascular and Immune System - Immune function ---> Cytokine secretion
●Musculoskeletal system - Bone properties ---> Bone strength
●Musculoskeletal system - Bone properties ---> Bone mass
●Other profiles - Medication use ---> Pegylated interleukin-2
SLID-058 Urinary excretion of LH and testosterone from male rats during exposure to increased gravity: post-spaceflight and centrifugation Investigated Organism: Rattus norvegicus;
Studied Organism Strains: SpragueDawley-derived;
Organism Common Name: Rat;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Urine;
●n.a.
 ●Fertility
 ●Nervous and regulatory systems - Endocrine function ---> Luteinizing hormone content
●Nervous and regulatory systems - Endocrine function ---> Testosterone content
SLID-059 The effects of 10 days of spaceflight on the shuttle Endeavor on predominantly fast-twitch muscles in the rat Investigated Organism: Rattus norvegicus;
Studied Organism Strains: Fischer 344;
Organism Common Name: Rat;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Muscle;
●n.a.
 ●Muscle atrophy
 ●Musculoskeletal system - Muscle properties ---> Muscle structure
●Musculoskeletal system - Muscle properties ---> Muscle proteins
●Musculoskeletal system - Muscle properties ---> Muscle plasticity
SLID-060 Space shuttle flight (STS-90) enhances degradation of rat myosin heavy chain in association with activation of ubiquitin-proteasome pathway Investigated Organism: Rattus norvegicus;
Studied Organism Strains: Wistar;
Organism Common Name: Rat;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Muscle;
●n.a.
 ●Muscle atrophy
 ●Musculoskeletal system - Muscle properties ---> Ubiquitin-proteasome
●Musculoskeletal system - Muscle properties ---> Myosin heavy chain degradation
SLID-061 Skeletal muscle gene expression in space-flown rats Investigated Organism: Rattus norvegicus;
Studied Organism Strains: SpragueDawley-derived;
Organism Common Name: Rat;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Muscle;
●n.a.
 ●Muscle atrophy
 ●Omics - Transcriptome ---> Muscle
SLID-062 Effects of spaceflight on myosin heavy-chain content, fibre morphology and succinate dehydrogenase activity in rat diaphragm Investigated Organism: Rattus norvegicus;
Studied Organism Strains: SpragueDawley-derived;
Organism Common Name: Rat;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Muscle;
●n.a.
 ●Muscle atrophy
 ●Musculoskeletal system - Muscle properties ---> Myosin heavy-chain content
●Musculoskeletal system - Muscle properties ---> Fibre morphology
●Musculoskeletal system - Muscle properties ---> Succinate dehydrogenase activity
SLID-063 Comparison of cell body size and oxidative enzyme activity in motoneurons between the cervical and lumbar segments in the rat spinal cord after spaceflight and recovery Investigated Organism: Rattus norvegicus;
Studied Organism Strains: SpragueDawley-derived;
Organism Common Name: Rat;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Neurons;
●n.a.
 ●Muscle atrophy
 ●Nervous and regulatory systems - Neural properties ---> Neuronal morphology
●Nervous and regulatory systems - Neural properties ---> Neuronal activity
SLID-064 Resveratrol prevents the wasting disorders of mechanical unloading by acting as a physical exercise mimetic in the rat Investigated Organism: Rattus norvegicus;
Studied Organism Strains: Wistar;
Organism Common Name: Rat;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Blood; Muscle; Bone;
●n.a.
 ●Bone loss
●Inflammation
●Muscle atrophy
 ●Other profiles - Medication use ---> Resveratrol
●Other profiles - Medication use ---> Physical exercise mimetic
●Nervous and regulatory systems - Endocrine function ---> Wasting disorders
●Nervous and regulatory systems - Endocrine function ---> Insulin sensitivity
●Cardiovascular and Immune System - Immune function ---> Inflammation
●Musculoskeletal system - Muscle properties ---> Muscle mechanics
●Musculoskeletal system - Bone properties ---> Bone shape
●Musculoskeletal system - Bone properties ---> Bone mechanics
SLID-065 Observing the mouse thyroid sphingomyelin under space conditions: a case study from the MDS mission in comparison with hypergravity conditions Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Thyroid;
●n.a.
 ●Immune system dysregulation
 ●Other profiles - Organ morphology ---> Thyroid
●Nervous and regulatory systems - Endocrine function ---> Thyroid gland enzymes
●Nervous and regulatory systems - Endocrine function ---> Sphingomyelin metabolism dysregulation
●Environment - Hypergravity
SLID-066 Effect of actual long-term spaceflight on BDNF, TrkB, p75, BAX and BCL-XL genes expression in mouse brain regions Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Brain;
●n.a.
 ●Neurodegenerative disease
●Behavioral abnormalities
 ●Nervous and regulatory systems - Neural properties ---> Neurogenesis
●Nervous and regulatory systems - Neural properties ---> Neuronal apoptosis
●Nervous and regulatory systems - Neural properties ---> Proapoptotic factor
●Nervous and regulatory systems - Neural properties ---> Antiapoptotic factor
●Nervous and regulatory systems - Neural properties ---> Neurotrophic factor
SLID-067 Spaceflight Effects on Cytochrome P450 Content in Mouse Liver Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Liver;
●n.a.
 ●Drug metabolism change
 ●Digestive and Excretory System - Liver function ---> Cytochrome P450
●Digestive and Excretory System - Liver function ---> Biotransformation
SLID-068 The effect of long-term hindlimb unloading on the expression of risk neurogenes encoding elements of serotonin-, dopaminergic systems and apoptosis; comparison with the effect of actual spaceflight on mouse brain Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Brain;
●n.a.
 ●Neurodegenerative disease
 ●Nervous and regulatory systems - Neural properties ---> Neuroplasticity
●Nervous and regulatory systems - Neural properties ---> Dopaminergic system
●Nervous and regulatory systems - Neural properties ---> Serotoninergic system
SLID-069 Healthy offspring from freeze-dried mouse spermatozoa held on the International Space Station for 9 months Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6N;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Spermatozoa;
●n.a.
 ●Fertility
 ●Development and Reproduction - Reproduction ---> Fertilization rate
●Development and Reproduction - Reproduction ---> Birth rate
●Omics - DNA damage
●Environment - Radiation
SLID-070 One-month spaceflight compromises the bone microstructure, tissue-level mechanical properties, osteocyte survival and lacunae volume in mature mice skeletons Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6N;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone;
●n.a.
 ●Bone loss
●Aging
 ●Musculoskeletal system - Bone properties ---> Bone volume
●Musculoskeletal system - Bone properties ---> Bone resorption
●Musculoskeletal system - Bone properties ---> Fatty marrow
●Musculoskeletal system - Bone properties ---> Osteocyte death
●Musculoskeletal system - Bone properties ---> Lacunae mineralization
SLID-071 Thirty days of spaceflight does not alter murine calvariae structure despite increased Sost expression Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6N;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone;
●n.a.
 ●Bone loss
 ●Musculoskeletal system - Bone properties ---> Bone structure
●Musculoskeletal system - Bone properties ---> Calvaria mechanotransduction pathways
●Musculoskeletal system - Bone properties ---> Sclerostin
SLID-072 Stromal and Hematopoietic Progenitors from C57/BI/6N Murine Bone Marrow After 30-Day "BION-M1" Spaceflight Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6N;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone marrow;
●n.a.
 ●Immune system dysregulation
 ●Musculoskeletal system - Bone properties ---> Bone Marrow cell population
●Musculoskeletal system - Bone properties ---> Bone Marrow cell function
SLID-073 Space radiation triggers persistent stress response, increases senescent signaling, and decreases cell migration in mouse intestine Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Intestine;
●n.a.
 ●Gastrointestinal homeostasis
 ●Environment - Radiation
●Digestive and Excretory System - Gastrointestinal properties ---> Persistent stress response
●Digestive and Excretory System - Gastrointestinal properties ---> Senescent signaling
●Digestive and Excretory System - Gastrointestinal properties ---> Cell migration
SLID-074 Analysis of femurs from mice embarked on board BION-M1 biosatellite reveals a decrease in immune cell development, including B cells, after 1 wk of recovery on Earth Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6N;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone marrow; Spleen;
●n.a.
 ●Immune system dysregulation
 ●Cardiovascular and Immune System - Immune function ---> B lymphopoiesis reduction
●Cardiovascular and Immune System - Immune function ---> Increased susceptibility to infection
SLID-075 Down-regulation of GATA1-dependent erythrocyte-related genes in the spleens of mice exposed to a space travel Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Spleen; Blood;
●n.a.
 ●Immune system dysregulation
 ●Other profiles - Organ morphology ---> Spleen mass and structure
●Cardiovascular and Immune System - Immune function ---> Plasma immunoglobulin concentration
●Omics - Transcriptome ---> Spleen
●Environment - Artificial gravity
SLID-076 Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Eye;
●Fluid dynamics - Hemodynamics
 ●Visual impairment
 ●Nervous and regulatory systems - Eye properties ---> Intraocular pressure
●Nervous and regulatory systems - Eye properties ---> Apoptosis
●Nervous and regulatory systems - Eye properties ---> Blood-retinal barrier
●Nervous and regulatory systems - Eye properties ---> Ocular structural
SLID-077 Hypergravity disrupts murine intestinal microbiota Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Microbiota;
●n.a.
 ●Gastrointestinal homeostasis
 ●Omics - Microbiome ---> Gut
●Other profiles - Organ morphology ---> Mucosal integrity
●Environment - Hypergravity
SLID-078 Spaceflight influences gene expression, photoreceptor integrity, and oxidative stress-related damage in the murine retina Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Eye;
●n.a.
 ●Oxidative damage
●Visual impairment
 ●Nervous and regulatory systems - Eye properties ---> Photoreceptor integrity
●Nervous and regulatory systems - Eye properties ---> Oxidative stress-related damage
SLID-079 Male mice, caged in the International Space Station for 35 days, sire healthy offspring Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Reproduction organs;
●n.a.
 ●Fertility
●Development impairment
 ●Development and Reproduction - Development ---> Male reproductive organs
●Development and Reproduction - Reproduction ---> Fertilization
●Development and Reproduction - Reproduction ---> Sperm function
●Development and Reproduction - Reproduction ---> Offspring viability
●Environment - Artificial gravity
SLID-080 Effects of spaceflight on the mouse submandibular gland Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Submandibular gland; Saliva;
●n.a.
 ●n.a.
 ●Nervous and regulatory systems - Endocrine function ---> Secretory protein expression
SLID-081 Validation of a New Rodent Experimental System to Investigate Consequences of Long Duration Space Habitation Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Whole animal; Whole animal; Liver; Spleen; Thymus; Adrenal gland; Muscle;
●n.a.
 ●Muscle atrophy
 ●Other profiles - Methodology ---> Equipment test
●Other profiles - Organ morphology ---> Liver
●Other profiles - Organ morphology ---> Spleen
●Other profiles - Organ morphology ---> Thymus
●Other profiles - Organ morphology ---> Adrenal glands
●Musculoskeletal system - Muscle properties ---> Muscle mass
●Nervous and regulatory systems - Behavior ---> Physical activity
SLID-082 Spaceflight affects neuronal morphology and alters transcellular degradation of neuronal debris in adult Caenorhabditis elegans Investigated Organism: Caenorhabditis elegans;
Organism Common Name: Nematode;
Organism Class: Worm;
Studied Organ/Tissue/Part: Neurons;
●n.a.
 ●Neurodegenerative disease
 ●Nervous and regulatory systems - Neural properties ---> Neuronal morphology
●Nervous and regulatory systems - Neural properties ---> Neuronal debris clearance
SLID-083 Effects of a Four-day Spaceflight and Recombinant Human Growth Hormone on Cancellous Bone Microarchitecture in Femoral Head of Rapidly Growing Male Rats Investigated Organism: Rattus norvegicus;
Studied Organism Strains: SpragueDawley-derived;
Organism Common Name: Rat;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone;
●n.a.
 ●Bone loss
 ●Musculoskeletal system - Bone properties ---> Bone volume
●Musculoskeletal system - Bone properties ---> Bone structure
●Musculoskeletal system - Bone properties ---> Bone lose
●Other profiles - Medication use ---> Recombinant human growth hormone
SLID-084 Persistent deterioration of visuospatial performance in spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Behavior;
●n.a.
 ●Cognitive decline
●Sensorimotor decline
 ●Nervous and regulatory systems - Neuromotor control ---> Electrophysiological responses
●Nervous and regulatory systems - Neuro-sensory function ---> Visuospatial performance
●Nervous and regulatory systems - Cognitive performance
SLID-085 Behavior of mice aboard the International Space Station Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●n.a.
 ●Nervous and regulatory systems - Behavior ---> Physical activity
●Nervous and regulatory systems - Behavior ---> Circling behavior
●Nervous and regulatory systems - Behavior ---> Race-tracking
SLID-086 Thermoregulatory responses of Rhesus monkeys during spaceflight Investigated Organism: Macaca mulatta;
Organism Common Name: Rhesus monkey;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Body temperature;
●Fluid dynamics - Hemodynamics
●Heat conduction - Body temperature
 ●Fever
 ●Nervous and regulatory systems - Body temperature ---> Axillary temperature
●Nervous and regulatory systems - Body temperature ---> Ankle skin temperature
●Nervous and regulatory systems - Body temperature ---> Thermoregulatory responses
●Cardiovascular and Immune System - Cardiovascular properties ---> Heart rate
●Cardiovascular and Immune System - Cardiovascular properties ---> Circadian rhythms
SLID-087 A spaceflight study of synaptic plasticity in adult rat vestibular maculas Investigated Organism: Rattus norvegicus;
Studied Organism Strains: SpragueDawley-derived;
Organism Common Name: Rat;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Vestibular organs;
●Inertial forces - Otolith system
 ●Stress
 ●Nervous and regulatory systems - Neural properties ---> Synaptic plasticity
●Nervous and regulatory systems - Neuro-sensory function ---> Neurovestibular center structural modification
●Nervous and regulatory systems - Behavior ---> Chromodacryorrhea
●Nervous and regulatory systems - Behavior ---> Abnormal posture and movement
SLID-088 Effects of spaceflight on bone mineralization in the rhesus monkey Investigated Organism: Macaca mulatta;
Organism Common Name: Rhesus monkey;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone;
●n.a.
 ●Bone loss
 ●Musculoskeletal system - Bone properties ---> Bone mineralization
●Musculoskeletal system - Bone properties ---> Bone volume
SLID-089 Effects of 14 days of spaceflight and nine days of recovery on cell body size and succinate dehydrogenase activity of rat dorsal root ganglion neurons Investigated Organism: Rattus norvegicus;
Studied Organism Strains: SpragueDawley-derived;
Organism Common Name: Rat;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Nerve;
●n.a.
 ●Neurovestibular decline
 ●Nervous and regulatory systems - Neuro-sensory function ---> Proprioception
SLID-090 Spaceflight affects bone formation in rhesus monkeys: a histological and cell culture study Investigated Organism: Macaca mulatta;
Organism Common Name: Rhesus monkey;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone;
●n.a.
 ●Bone loss
 ●Musculoskeletal system - Bone properties ---> Bone structure
●Musculoskeletal system - Bone properties ---> Bone formation
●Musculoskeletal system - Bone properties ---> Osteoblastic cell proliferation
SLID-091 Effects of spaceflight on innate immune function and antioxidant gene expression Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Thymus; Spleen; Liver;
●n.a.
 ●Immune system dysregulation
 ●Cardiovascular and Immune System - Immune function ---> Blastogenesis
●Cardiovascular and Immune System - Immune function ---> Blood cell population
●Cardiovascular and Immune System - Immune function ---> Cytokine concentrition
SLID-092 Evaluation of gene, protein and neurotrophin expression in the brain of mice exposed to space environment for 91 days Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/10J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Brain;
●n.a.
 ●n.a.
 ●Omics - Transcriptome ---> Brain
●Omics - Proteome ---> Brain
SLID-093 Effects of spaceflight and ground recovery on mesenteric artery and vein constrictor properties in mice Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Vessel;
●Fluid dynamics - Hemodynamics
 ●Unstable blood pressure
 ●Cardiovascular and Immune System - Cardiovascular properties ---> Blood pressure
●Cardiovascular and Immune System - Cardiovascular properties ---> Vessel morphology
●Cardiovascular and Immune System - Cardiovascular properties ---> Mesenteric artery
●Cardiovascular and Immune System - Cardiovascular properties ---> Vein constrictor properties
●Cardiovascular and Immune System - Cardiovascular properties ---> Vasoconstrictor responses
●Cardiovascular and Immune System - Cardiovascular properties ---> Orthostatic stress
●Other profiles - Medication use ---> Norepinephrine
●Other profiles - Medication use ---> Potassium chloride
●Other profiles - Medication use ---> Caffeine
SLID-094 Spaceflight-induced alterations in cerebral artery vasoconstrictor, mechanical, and structural properties: implications for elevated cerebral perfusion and intracranial pressure Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Brain; Vessel;
●Fluid dynamics - Hemodynamics
 ●Brain damage
 ●Nervous and regulatory systems - Brain properties ---> Cerebral arteries function
●Nervous and regulatory systems - Brain properties ---> Cerebral arteries mechanics
●Nervous and regulatory systems - Brain properties ---> Cerebral arteries structure
●Nervous and regulatory systems - Brain properties ---> Cerebral perfusion
●Nervous and regulatory systems - Brain properties ---> Intracranial pressure
SLID-095 Risk neurogenes for long-term spaceflight: dopamine and serotonin brain system Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Brain;
●n.a.
 ●Locomotor impairment
 ●Nervous and regulatory systems - Brain properties ---> Brain dopaminergic and serotonergic systems
SLID-096 Spaceflight on the Bion-M1 biosatellite alters cerebral artery vasomotor and mechanical properties in mice Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6N;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Vessel; Brain;
●Fluid dynamics - Hemodynamics
 ●Brain damage
 ●Nervous and regulatory systems - Brain properties ---> Cerebral arteries function
●Nervous and regulatory systems - Brain properties ---> Cerebral arteries mechanics
●Nervous and regulatory systems - Brain properties ---> Cerebral arteries structure
●Nervous and regulatory systems - Brain properties ---> Cerebral perfusion
SLID-097 Effects of microgravity on DNA damage response in Caenorhabditis elegans during Shenzhou-8 spaceflight Investigated Organism: Caenorhabditis elegans;
Organism Common Name: Nematode;
Organism Class: Worm;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●Aging
 ●Omics - DNA damage
●Omics - Transcriptome ---> Whole animal
SLID-098 Spaceflight impairs antigen-specific tolerance induction in vivo and increases inflammatory cytokines Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Lymph node; Spleen; Leukocytes;
●n.a.
 ●Immune system dysregulation
 ●Cardiovascular and Immune System - Immune function ---> Immune tolerance impairement
●Cardiovascular and Immune System - Immune function ---> Lymphocytes population
●Cardiovascular and Immune System - Immune function ---> Cytokine content
SLID-099 Osteoprotegerin is an effective countermeasure for spaceflight-induced bone loss in mice Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone;
●n.a.
 ●Bone loss
 ●Musculoskeletal system - Bone properties ---> Bone lose
●Musculoskeletal system - Bone properties ---> Bone mechanical properties
●Musculoskeletal system - Bone properties ---> Bone mass
●Musculoskeletal system - Bone properties ---> Bone components
●Other profiles - Medication use ---> Osteoprotegerin
SLID-100 BION-M 1: First continuous blood pressure monitoring in mice during a 30-day spaceflight Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Vessel; Heart;
●Fluid dynamics - Hemodynamics
 ●Cardiovascular deconditioning
 ●Cardiovascular and Immune System - Cardiovascular properties ---> Blood pressure
●Cardiovascular and Immune System - Cardiovascular properties ---> Hydrostatic pressure
SLID-101 Socioenvironmental stressors encountered during spaceflight partially affect the murine TCR-β repertoire and increase its self-reactivity Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6N;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Leukocytes; Thymocytes;
●n.a.
 ●Stress
●Pregnant
●Immune system dysregulation
 ●Cardiovascular and Immune System - Immune function ---> T lymphopoiesis
●Cardiovascular and Immune System - Immune function ---> Thymocyte maturation
●Environment - Socioenvironmental stressors
SLID-102 Articular cartilage and sternal fibrocartilage respond differently to extended microgravity Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6N;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Cartilage;
●n.a.
 ●n.a.
 ●Musculoskeletal system - Cartilage properties
SLID-103 Hypergravity and microgravity exhibited reversal effects on the bone and muscle mass in mice Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone;
●n.a.
 ●Muscle atrophy
●Bone loss
 ●Musculoskeletal system - Bone properties
●Musculoskeletal system - Muscle properties
●Environment - Hypergravity
SLID-104 Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space Investigated Organism: Mus musculus;
Studied Organism Strains: MuRF1 KO;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Muscle;
●n.a.
 ●Muscle atrophy
 ●Musculoskeletal system - Muscle properties
SLID-105 The effects of spaceflight and fracture healing on distant skeletal sites Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone;
●n.a.
 ●Wound healing
●Bone loss
 ●Musculoskeletal system - Bone properties ---> Bone loss
●Musculoskeletal system - Bone properties ---> Bone geometry
●Development and Reproduction - Regeneration ---> Fracture healing
SLID-106 Skeletal adaptations in young male mice after 4 weeks aboard the International Space Station Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone;
●n.a.
 ●Development impairment
●Bone loss
 ●Musculoskeletal system - Bone properties ---> Skeletal adaptation
●Musculoskeletal system - Bone properties ---> Bone mass
●Development and Reproduction - Development ---> Skeletal maturation
SLID-107 Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone;
●n.a.
 ●Bone loss
 ●Musculoskeletal system - Bone properties ---> Bone micro-architectural
●Musculoskeletal system - Bone properties ---> Bone mechanical properties
●Other profiles - Medication use ---> Dried plum powder
●Environment - Simulated microgravity
●Environment - Radiation
SLID-108 Dynamics of entomopathogenic nematode foraging and infectivity in microgravity Investigated Organism: Steinernema feltiae;
Organism Common Name: Nematode;
Organism Class: Worm;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●Infectious disease
 ●Nervous and regulatory systems - Behavior ---> Foraging
●Nervous and regulatory systems - Behavior ---> Crop protection
●Other profiles - Parasite infectivity
SLID-109 Spaceflight induces oxidative damage to blood-brain barrier integrity in a mouse model Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Brain; Blood-brain barrier;
●Fluid dynamics - Hemodynamics
 ●Brain damage
●Oxidative damage
 ●Nervous and regulatory systems - Brain properties ---> Blood-brain barrier integrity
●Nervous and regulatory systems - Neural properties ---> Neurovascular damage
●Omics - Proteome ---> Brain
SLID-110 Bioinformatic Analysis of the Sciatic Nerve Transcriptomes of Mice after 30-Day Spaceflight on Board the Bion-M1 Biosatellite Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Nerve;
●n.a.
 ●n.a.
 ●Omics - Transcriptome ---> Sciatic nerve
SLID-111 Vestibular cerebellum of thick-toed geckos (Chondrodactylus turnery GRAY, 1864) and C57/BL6N mice after the long-term space flight on the biosatellite BION-M1 Investigated Organism: Mus musculus; Chondrodactylus turneri;
Studied Organism Strains: GRAY,1864; C57/BL6N;
Organism Common Name: Thick-toed gecko; Mice;
Organism Class: Reptile; Mammalia;
Studied Organ/Tissue/Part: Vestibular organs;
●n.a.
 ●n.a.
 ●Nervous and regulatory systems - Neural properties ---> Cellular pathomorphological change
SLID-112 Effects of spaceflight on ocular counterrolling and the spatial orientation of the vestibular system Investigated Organism: Macaca mulatta;
Organism Common Name: Rhesus monkey;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Eye;
●n.a.
 ●Visuo-motor disorder
 ●Nervous and regulatory systems - Neuro-sensory function ---> Ocular counterrolling reduce
●Nervous and regulatory systems - Neuro-sensory function ---> Spatial orientation shift
SLID-113 Embryonic quail eye development in microgravity Investigated Organism: Coturnix coturnix;
Organism Common Name: Quail;
Organism Class: Bird;
Studied Organ/Tissue/Part: Embryos;
●n.a.
 ●Development impairment
 ●Development and Reproduction - Development ---> Eye development
SLID-114 Weightlessness during spaceflight results in enhanced synapse formation in a fish brain vestibular nucleus Investigated Organism: Xiphophorus helleri;
Organism Common Name: Swordtail fish;
Organism Class: Fish;
Studied Organ/Tissue/Part: Vestibular organs;
●n.a.
 ●Development impairment
 ●Development and Reproduction - Development ---> Synapse formation
●Development and Reproduction - Development ---> Brain vestibular nucleus
SLID-115 Mechanism of vestibular adaptation of fish under microgravity Investigated Organism: Carassius auratus;
Organism Common Name: Goldfish;
Organism Class: Fish;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●n.a.
 ●Nervous and regulatory systems - Behavior ---> Looping and rolling behavior
●Nervous and regulatory systems - Behavior ---> Dorsal light responses
●Nervous and regulatory systems - Behavior ---> Body flexion
●Nervous and regulatory systems - Neuro-sensory function ---> Vestibular adaptation
SLID-116 Calcium utilization by quail embryos during activities preceding space flight and during embryogenesis in microgravity aboard the orbital space station MIR Investigated Organism: Coturnix coturnix;
Organism Common Name: Quail;
Organism Class: Bird;
Studied Organ/Tissue/Part: Embryos;
●n.a.
 ●Development impairment
 ●Development and Reproduction - Development ---> Calcium utilization
●Development and Reproduction - Development ---> Embryogenesis
SLID-117 The calcium endocrine system of adolescent rhesus monkeys and controls before and after spaceflight Investigated Organism: Macaca mulatta;
Organism Common Name: Rhesus monkey;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Blood;
●Fluid dynamics - Hemodynamics
 ●Endocrine disorders
 ●Nervous and regulatory systems - Endocrine function ---> Calcium endocrine system
SLID-118 Urodelean amphibians in studies on microgravity: effects upon organ and tissue regeneration Investigated Organism: Pleurodeles waltl;
Organism Common Name: Newt;
Organism Class: Amphibian;
Studied Organ/Tissue/Part: Eye;
●n.a.
 ●n.a.
 ●Development and Reproduction - Regeneration ---> Organ and tissue regeneration
●Development and Reproduction - Regeneration ---> Cell proliferation
●Environment - Simulated microgravity
SLID-119 Morphometric investigations of sensory vestibular structures in tadpoles (Xenopus laevis) after a spaceflight: implications for microgravity-induced alterations of the vestibuloocular reflex Investigated Organism: Xenopus laevis;
Organism Common Name: African Clawed Frog;
Organism Class: Amphibian;
Studied Organ/Tissue/Part: Vestibular organs;
●n.a.
 ●n.a.
 ●Development and Reproduction - Development ---> Otoliths shap
●Development and Reproduction - Development ---> CalBindin expressing cell
●Nervous and regulatory systems - Neuro-sensory function ---> Vestibular adaptation
●Nervous and regulatory systems - Neuro-sensory function ---> Vestibuloocular reflex
SLID-120 Spaceflight-associated changes in immunoglobulin VH gene expression in the amphibian Pleurodeles waltl Investigated Organism: Pleurodeles waltl;
Organism Common Name: Newt;
Organism Class: Amphibian;
Studied Organ/Tissue/Part: Spleen;
●n.a.
 ●n.a.
 ●Cardiovascular and Immune System - Immune function ---> IgM heavy-chain gene expression
SLID-121 Decrease in antibody somatic hypermutation frequency under extreme, extended spaceflight conditions Investigated Organism: Pleurodeles waltl;
Organism Common Name: Newt;
Organism Class: Amphibian;
Studied Organ/Tissue/Part: Spleen; Liver;
●n.a.
 ●n.a.
 ●Cardiovascular and Immune System - Immune function ---> IgM heavy-chain gene mutation
SLID-122 Gravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesis Investigated Organism: Pleurodeles waltl;
Organism Common Name: Newt;
Organism Class: Amphibian;
Studied Organ/Tissue/Part: Larvae;
●n.a.
 ●n.a.
 ●Cardiovascular and Immune System - Immune function ---> IgM heavy-chain gene expression
●Cardiovascular and Immune System - Immune function ---> Lymphopoiesis
SLID-123 Changes in titin and myosin heavy chain isoform composition in skeletal muscles of Mongolian gerbil (Meriones unguiculatus) after 12-day spaceflight Investigated Organism: Meriones unguiculatus;
Organism Common Name: Mongolian jird;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Muscle;
●n.a.
 ●Muscle atrophy
 ●Musculoskeletal system - Muscle properties ---> Muscle composition
●Musculoskeletal system - Muscle properties ---> Titin
●Musculoskeletal system - Muscle properties ---> Myosin heavy chain isoform
SLID-124 Microgravity promotes osteoclast activity in medaka fish reared at the international space station Investigated Organism: Oryzias latipes;
Organism Common Name: Medaka fish;
Organism Class: Fish;
Studied Organ/Tissue/Part: Whole animal; Bone;
●n.a.
 ●n.a.
 ●Musculoskeletal system - Bone properties ---> Bone mineral density
●Musculoskeletal system - Bone properties ---> Osteoclasts mitochondria roundness
●Musculoskeletal system - Bone properties ---> Osteoclast activation
●Nervous and regulatory systems - Behavior ---> Motionless
●Omics - Transcriptome
SLID-125 Evaluation of rodent spaceflight in the NASA animal enclosure module for an extended operational period (up to 35 days) Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Whole animal; Thymus; Adrenal gland; Spleen; Heart; Lungs; Blood;
●n.a.
 ●n.a.
 ●Other profiles - Equipment test
●Other profiles - Organ morphology ---> Thymus
●Other profiles - Organ morphology ---> Adrenals
●Other profiles - Organ morphology ---> Spleen
●Other profiles - Organ morphology ---> Heart
●Other profiles - Organ morphology ---> Lungs
●Nervous and regulatory systems - Behavior ---> Food consumption
●Nervous and regulatory systems - Behavior ---> Water consumption
●Cardiovascular and Immune System - Blood components ---> Blood proteins
●Cardiovascular and Immune System - Blood components ---> Blood cells
●Cardiovascular and Immune System - Blood components ---> Blood elements
●Other profiles - Methodology ---> Equipment test
SLID-126 Behavior of Stem-Like Cells, Precursors for Tissue Regeneration in Urodela, Under Conditions of Microgravity Investigated Organism: Pleurodeles waltl;
Organism Common Name: Newt;
Organism Class: Amphibian;
Studied Organ/Tissue/Part: Stem-Like Cells;
●n.a.
 ●n.a.
 ●Development and Reproduction - Regeneration ---> Stem-like cell-dependent regeneration
SLID-127 Radiation and microgravity effects observed in the insect system Carausius morosus Investigated Organism: Carausius morosus;
Organism Common Name: Indian stick insect;
Organism Class: Arthropod;
Studied Organ/Tissue/Part: Egg;
●n.a.
 ●n.a.
 ●Development and Reproduction - Development ---> Embryogenesis
●Development and Reproduction - Development ---> Hatching rate
●Development and Reproduction - Development ---> Growth kinetics
●Development and Reproduction - Development ---> Anomaly frequency
●Environment - Radiation
SLID-128 Embryonic Development and Behaviour of Japanese Quail Exposed to Microgravity Investigated Organism: Coturnix coturnix;
Organism Common Name: Quail;
Organism Class: Bird;
Studied Organ/Tissue/Part: Embryos;
●n.a.
 ●Development impairment
 ●Development and Reproduction - Development ---> Embryogenesis
●Development and Reproduction - Development ---> Eye development
●Development and Reproduction - Development ---> Brain development
●Development and Reproduction - Development ---> Beak development
●Development and Reproduction - Development ---> Embryos morphology
SLID-129 The Quail Embryonic Development Under the Conditions of Weightlessness Investigated Organism: Coturnix coturnix;
Organism Common Name: Quail;
Organism Class: Bird;
Studied Organ/Tissue/Part: Embryos;
●n.a.
 ●Development impairment
 ●Development and Reproduction - Development ---> Embryogenesis
●Development and Reproduction - Development ---> Shatching rate
●Development and Reproduction - Development ---> Anomalies
SLID-130 Ophthalmic changes and increased intracranial pressure associated with long duration spaceflight: An emerging understanding Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Brain; Eye;
●Fluid dynamics - Hemodynamics
 ●Visual impairment
 ●Nervous and regulatory systems - Neuro-sensory function ---> Visual impairment
●Nervous and regulatory systems - Neuro-sensory function ---> Visual acuity shift
●Nervous and regulatory systems - Neuro-sensory function ---> Ophthalmic changes
●Nervous and regulatory systems - Neuro-sensory function ---> Intracranial pressure
SLID-131 Circadian misalignment affects sleep and medication use before and during spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Behavior;
●n.a.
 ●Sleeplessness
 ●Nervous and regulatory systems - Sleep ---> Nervous and regulatory systems - Sleep deficiency
●Other profiles - Medication use ---> Hypnotic drug
●Cardiovascular and Immune System - Circadian rhythm ---> Circadian misalignment
SLID-132 Medication use by U.S. crewmembers on the International Space Station Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Behavior;
●n.a.
 ●n.a.
 ●Other profiles - Medication use ---> Hypnotic drug
●Other profiles - Medication use ---> Pain relievers
●Other profiles - Medication use ---> Antifungal preparations
●Other profiles - Medication use ---> Steroid
●Other profiles - Medication use ---> Antihistamines
SLID-133 Characterization of sleep-wake patterns in crew members under a short-duration spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Behavior; Heart;
●n.a.
 ●Sleeplessness
 ●Nervous and regulatory systems - Sleep ---> Nervous and regulatory systems - Sleep deficiency
●Nervous and regulatory systems - Sleep ---> Nervous and regulatory systems - Sleep-wake patterns
●Cardiovascular and Immune System - Heart rhythm ---> Heart rate
SLID-134 Effects of Spaceflight on Astronaut Brain Structure as Indicated on MRI Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Brain;
●Fluid dynamics - Hemodynamics
 ●Brain damage
 ●Nervous and regulatory systems - Brain structure ---> Cerebrospinal fluid space narrowing
●Nervous and regulatory systems - Brain structure ---> Ventricular volume
●Nervous and regulatory systems - Brain structure ---> Central sulcus narrowing
●Nervous and regulatory systems - Brain structure ---> Brain upward shift
SLID-135 Changes in human skeletal muscle architecture and function induced by extended spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Muscle;
●n.a.
 ●Muscle atrophy
 ●Musculoskeletal system - Muscle properties ---> Muscle strength
●Musculoskeletal system - Muscle properties ---> Muscle architecture
●Musculoskeletal system - Muscle properties ---> Fiber length
●Musculoskeletal system - Muscle properties ---> Pennation angle
SLID-136 The effect of long-term exposure to microgravity on the perception of upright Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Behavior;
●n.a.
 ●Neurovestibular decline
 ●Nervous and regulatory systems - Neuro-sensory function ---> Perception of upright
●Nervous and regulatory systems - Neuro-sensory function ---> Orientation
SLID-137 Spaceflight-induced cardiovascular changes and recovery during NASA's Functional Task Test Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Heart;
●Fluid dynamics - Hemodynamics
 ●Cardiac rhythm disturbances
 ●Cardiovascular and Immune System - Heart rhythm ---> Mean heart rate
●Cardiovascular and Immune System - Heart rhythm ---> Heart rate variability
●Nervous and regulatory systems - Vegetative nervous system function ---> Autonomic activity
●Nervous and regulatory systems - Vegetative nervous system function ---> Parasympathetic modulation
●Nervous and regulatory systems - Vegetative nervous system function ---> Sympathovagal balance
SLID-138 Long-term exposure to microgravity impairs vestibulo-cardiovascular reflex Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Vessel;
●Fluid dynamics - Hemodynamics
 ●Orthostatic intolerance
 ●Nervous and regulatory systems - Neuro-sensory function ---> Vestibulo-cardiovascular reflex impairment
●Cardiovascular and Immune System - Vessel properties ---> Blood pressure
SLID-139 Study of the impact of long-duration space missions at the International Space Station on the astronaut microbiome Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Microbiota;
●n.a.
 ●Hypersensitivity
●Gastrointestinal homeostasis
 ●Omics - Microbiome ---> Gut
●Omics - Microbiome ---> Skin
●Cardiovascular and Immune System - Immune function ---> Cytokine profile
SLID-140 Long-duration spaceflight adversely affects post-landing operator proficiency Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Behavior;
●n.a.
 ●Sensorimotor decline
●Cognitive decline
 ●Nervous and regulatory systems - Neuromotor control ---> Manual dexterity
●Nervous and regulatory systems - Neuromotor control ---> Dual-tasking
●Nervous and regulatory systems - Neuromotor control ---> Motion perception
●Nervous and regulatory systems - Cognitive performance
SLID-141 Inflight leg cuff test does not identify the risk for orthostatic hypotension after long-duration spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Vessel; Heart;
●Fluid dynamics - Hemodynamics
 ●Orthostatic intolerance
 ●Cardiovascular and Immune System - Heart rhythm ---> Heart rate
●Cardiovascular and Immune System - Vessel properties ---> Systolic pressure
●Cardiovascular and Immune System - Vessel properties ---> Diastolic pressure
●Cardiovascular and Immune System - Vessel properties ---> Mean arterial pressure
●Cardiovascular and Immune System - Vessel properties ---> Baroreflex response
SLID-142 Mental performance in extreme environments: results from a performance monitoring study during a 438-day spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Behavior;
●n.a.
 ●Cognitive decline
●Mood impairment
 ●Nervous and regulatory systems - Psychology ---> Mental performance
●Nervous and regulatory systems - Psychology ---> Mood
●Nervous and regulatory systems - Cognitive performance
SLID-143 Impaired pressor response after spaceflight and bed rest: evidence for cardiovascular dysfunction Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Vessel; Heart;
●Fluid dynamics - Hemodynamics
 ●Blood pressor response impairment
 ●Cardiovascular and Immune System - Heart rhythm ---> Heart rate
●Cardiovascular and Immune System - Vessel properties ---> Pressor response
●Cardiovascular and Immune System - Vessel properties ---> Isometric muscle action
●Cardiovascular and Immune System - Vessel properties ---> Mean arterial pressure
SLID-144 Heart rate variability and short duration spaceflight: relationship to post-flight orthostatic intolerance Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Heart;
●Fluid dynamics - Hemodynamics
●Statistical physics of fluctuation system - Heartbeat fluctuation
 ●Orthostatic intolerance
 ●Cardiovascular and Immune System - Heart rhythm ---> Heart rate variability
●Nervous and regulatory systems - Vegetative nervous system function ---> Parasympathetic activity
●Nervous and regulatory systems - Vegetative nervous system function ---> Sympathetic activity
●Nervous and regulatory systems - Vegetative nervous system function ---> Sympathovagal balance
SLID-145 B cell homeostasis is maintained during long-duration spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Blood;
●n.a.
 ●Immune system dysregulation
 ●Cardiovascular and Immune System - Immune function ---> B cell homeostasis
●Cardiovascular and Immune System - Immune function ---> B cell number
●Cardiovascular and Immune System - Immune function ---> B cell phenotype
●Cardiovascular and Immune System - Immune function ---> Plasama anti body concentrition
SLID-146 Brain ventricular volume changes induced by long-duration spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Brain;
●Fluid dynamics - Hemodynamics
 ●Brain damage
 ●Nervous and regulatory systems - Brain structure ---> Brain ventricular volume
●Nervous and regulatory systems - Brain structure ---> Cerebrospinal fluid volume
●Nervous and regulatory systems - Brain structure ---> Cerebrospinal fluid resorption
SLID-147 Resistive exercise in astronauts on prolonged spaceflights provides partial protection against spaceflight-induced bone loss Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Behavior; Urine; Blood; Bone;
●n.a.
 ●Bone loss
 ●Musculoskeletal system - Bone properties ---> Bone loss
●Musculoskeletal system - Bone properties ---> Bone mineral density
●Musculoskeletal system - Bone properties ---> Bone resorption
●Cardiovascular and Immune System - Blood components ---> Bone markers
●Digestive and Excretory System - Urine components ---> Bone markers
●Other profiles - Medication use ---> Exercise
SLID-148 Exercise as a countermeasure for latent viral reactivation during long duration space flight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Saliva; Urine; Blood;
●n.a.
 ●Latent viral reactivation
 ●Cardiovascular and Immune System - Immune function ---> Latent viral reactivation
●Other profiles - Medication use ---> Exercise
SLID-149 Non-linear heart rate control in orthostatic tolerant cosmonauts after short-duration spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Heart;
●Fluid dynamics - Hemodynamics
 ●Orthostatic intolerance
 ●Cardiovascular and Immune System - Heart rhythm ---> Heart rate variability
●Cardiovascular and Immune System - Heart rhythm ---> Non-linear heart rate control
SLID-150 Dysfunctional vestibular system causes a blood pressure drop in astronauts returning from space Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Vessel; Vestibular system;
●Fluid dynamics - Hemodynamics
 ●Unstable blood pressure
 ●Nervous and regulatory systems - Neuro-sensory function ---> Otolith system deconditioning
●Cardiovascular and Immune System - Vessel properties ---> Mean arterial pressure
●Cardiovascular and Immune System - Vessel properties ---> Blood pressure instability
●Nervous and regulatory systems - Vegetative nervous system function ---> Cardiovascular autonomic control
SLID-151 Macro- and microstructural changes in cosmonauts' brains after long-duration spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Brain;
●Fluid dynamics - Hemodynamics
 ●Brain damage
 ●Nervous and regulatory systems - Brain structure ---> White matter
●Nervous and regulatory systems - Brain structure ---> Gray matter
●Nervous and regulatory systems - Brain structure ---> Cerebrospinal fluid composition
●Nervous and regulatory systems - Neuro-sensory function ---> Visual acuity
●Nervous and regulatory systems - Neural properties ---> Motor strategies adaption
SLID-152 Understanding the effects of spaceflight on head–trunk coordination during walking and obstacle avoidance Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Behavior;
●n.a.
 ●Sensorimotor decline
 ●Nervous and regulatory systems - Neuromotor control ---> Head–trunk coordination
●Nervous and regulatory systems - Neuromotor control ---> Movement strategies
SLID-153 A microbial survey of the International Space Station (ISS) Investigated Organism: Microbiota;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria/Fungus;
Microbe Type: Microbiota;
Microbe Form: Spacecraft sample;
●n.a.
 ●n.a.
 ●Omics - Microbiome
●Other profiles - Microbial colonization on space crafts
●Omics - Spacecraft microbiome monitoring
SLID-154 Spaceflight Modifies Escherichia coli Gene Expression in Response to Antibiotic Exposure and Reveals Role of Oxidative Stress Response Investigated Organism: Escherichia coli;
Studied Organism Strains: ATCC 4157;
Organism Common Name: E. coli;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human opportunistic pathogen; Normal flora of Human; Model organism;
Microbe Form: Active organism;
●n.a.
 ●Antibiotic resistance
 ●Stress resistance - Oxidative stress resistance
●Omics - Transcriptome
SLID-155 Succession and persistence of microbial communities and antimicrobial resistance genes associated with International Space Station environmental surfaces Investigated Organism: Microbiota;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria/Fungus;
Microbe Type: Microbiota;
Microbe Form: Spacecraft sample;
●n.a.
 ●Antibiotic resistance
●Virulence
 ●Omics - Microbiome
●Cell behavior - Survival and growth ---> Cell viability
●Other profiles - Microbial colonization on space crafts
●Omics - Spacecraft microbiome monitoring
SLID-156 Comparison of Bacillus subtilis transcriptome profiles from two separate missions to the International Space Station Investigated Organism: Bacillus subtilis;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Model organism; Plant probiotic;
Microbe Form: Active organism;
●Polymer network-Biofilm ---> Biofilm formation
●Polymer network-Biofilm ---> Transcriptomic
 ●n.a.
 ●Omics - Transcriptome
SLID-157 Microbiomes of China's Space Station During Assembly, Integration, and Test Operations Investigated Organism: Microbiota;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria/Fungus;
Microbe Type: Microbiota;
Microbe Form: Spacecraft sample;
●n.a.
 ●n.a.
 ●Omics - Microbiome ---> China's space station samples
●Cell behavior - Survival and growth ---> Cell viability
●Other profiles - Microbial colonization on space crafts
●Omics - Spacecraft microbiome monitoring
SLID-158 Identification of potential tobramycin-resistant mutagenesis of Escherichia coli strains after spaceflight Investigated Organism: Escherichia coli;
Studied Organism Strains: T1_13;
Organism Common Name: E. coli;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Normal flora of Human; Human opportunistic pathogen; Model organism;
Microbe Form: Active organism;
●n.a.
 ●Antibiotic resistance
 ●Omics - Genome ---> Mutagenesis
●Omics - Transcriptome
SLID-159 Increased growth rate and amikacin resistance of Salmonella enteritidis after one-month spaceflight on China's Shenzhou-11 spacecraft Investigated Organism: Salmonella enteritidis;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human pathogen;
Microbe Form: Active organism;
●Polymer network-Biofilm ---> Biofilm growth
●Polymer network-Biofilm ---> Proteomic
 ●Antibiotic resistance
 ●Cell behavior - Survival and growth ---> Growth rate
●Morphology - Biofilm
SLID-160 Characterization of the total and viable bacterial and fungal communities associated with the International Space Station surfaces Investigated Organism: Microbiota;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria/Fungus;
Microbe Type: Microbiota;
Microbe Form: Spacecraft sample;
●n.a.
 ●n.a.
 ●Omics - Microbiome
●Other profiles - Microbial colonization on space crafts
●Omics - Spacecraft microbiome monitoring
SLID-161 Integrated proteomic and metabolomic analysis to study the effects of spaceflight on Candida albicans Investigated Organism: Candida albicans;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Fungus;
Microbe Type: Human opportunistic pathogen;
Microbe Form: Active organism;
●Polymer network-Biofilm ---> Biofilm formation
●Polymer network-Biofilm ---> Proteomic/Metabolomic
 ●Virulence
 ●Cell behavior - Survival and growth ---> Growth rate
●Morphology - Mycelium
●Stress resistance - Oxidative stress resistance
●Morphology - Biofilm
SLID-162 Genomic and phenotypic characterization of Burkholderia isolates from the potable water system of the International Space Station Investigated Organism: Burkholderia contaminans; Burkholderia cepacia;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human opportunistic pathogen;
Microbe Form: Active organism;
●Polymer network-Biofilm ---> Biofilm formation
●Polymer network-Biofilm ---> Genomic
 ●Virulence
 ●Omics - Genome ---> Mutagenesis
●Morphology - Biofilm
SLID-163 Space Station conditions are selective but do not alter microbial characteristics relevant to human health Investigated Organism: Microbiota;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria/Fungus;
Microbe Type: Microbiota;
Microbe Form: Active organism;
●Polymer network-Biofilm ---> Biofilm formation
●Polymer network-Biofilm ---> Genomic
 ●Antibiotic resistance
 ●Omics - Microbiome
●Stress resistance - Heat shock resistance
●Stress resistance - PH tolerance
●Morphology - Biofilm
SLID-164 Expression of stress response genes in barley Hordeum vulgare in a spaceflight environment Investigated Organism: Hordeum vulgare;
Organism Common Name: Barley;
Organism Class: Food;
Studied Organ/Tissue/Part: Seedling;
Food Category: Grain;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Omics - Transcriptomics ---> Seedling
●Omics - Transcriptomics of stress resistance ---> Heat shock response
●Omics - Transcriptomics of stress resistance ---> Pathogenesis-related response
●Omics - Transcriptomics of stress resistance ---> ROS scavenging response
SLID-165 Microgravity effects on thylakoid, single leaf, and whole canopy photosynthesis of dwarf wheat Investigated Organism: Triticum aestivum (Dwarf wheat);
Organism Common Name: n.a.;
Organism Class: Food;
Studied Organ/Tissue/Part: Leaf; Foil; Whole plant;
Food Category: Grain;
Growth Stage During Space Flight: Seed to mature plant;
●Light absorption and electron transfer - Photosynthesis
 ●n.a.
 ●Process - Photosynthesis ---> Photosynthetic photon flux
●Process - Photosynthesis ---> Quantum yield of canopy photosynthesis
●Process - Photosynthesis ---> Whole chain electron
●Process - Photosynthesis ---> Chlorophyll content
●Process - Photosynthesis ---> Chlorophyll fluorescence
●Growth - Whole plant ---> Plant dry mass
SLID-166 Microgravity effects on leaf morphology, cell structure, carbon metabolism and mRNA expression of dwarf wheat Investigated Organism: Triticum aestivum (Dwarf wheat);
Organism Common Name: n.a.;
Organism Class: Food;
Studied Organ/Tissue/Part: Leaf;
Food Category: Grain;
Growth Stage During Space Flight: Seed to mature plant;
●Light absorption and electron transfer - Photosynthesis - Chloroplasts
 ●n.a.
 ●Process - Photosynthesis ---> Chloroplast density
●Process - Photosynthesis ---> Chloroplast area
●Process - Photosynthesis ---> Chloroplast L/W
●Process - Photosynthesis ---> Thylakoid density
●Process - Photosynthesis ---> Thylakoid spacing
●Growth - Leaf ---> Leaf transverse thickness
●Growth - Leaf ---> Leaf cell density
●Growth - Leaf ---> Cell area
●Omics - Transcriptomics ---> RNA seq
●Omics - Transcriptomics ---> Leaf
●Component - Carbohydrate ---> Insoluble starch
●Component - Carbohydrate ---> Lignin
●Component - Carbohydrate ---> Coniferyl
●Component - Carbohydrate ---> Sinapyl
●Component - Carbohydrate ---> Rhamnose
●Component - Carbohydrate ---> Fucose
●Component - Carbohydrate ---> Arabinose
●Component - Carbohydrate ---> Xylose
●Component - Carbohydrate ---> Mannose
●Component - Carbohydrate ---> Galactose
●Component - Carbohydrate ---> Glucose
SLID-167 Quantification of four active ingredients and fingerprint analysis of Licorice (Glycyrrhiza uralensis Fisch.) after spaceflight by HPLC–DAD Investigated Organism: Glycyrrhiza uralensis;
Organism Common Name: Licorice;
Organism Class: Herb;
Studied Organ/Tissue/Part: Seed; Root;
Food Category: n.a.;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Component - Active ingredients ---> Isoliquiritin
●Component - Active ingredients ---> Liquiritigenin
●Component - Active ingredients ---> Isoliquirigenin
●Component - Active ingredients ---> Glabridin
SLID-168 STS-95 space experiment for plant growth and development, and auxin polar transport Investigated Organism: Pisum sativum; Zea mays;
Organism Common Name: Pea; Maize;
Organism Class: Food;
Studied Organ/Tissue/Part: Seedling; Epicotyls; Coleoptile;
Food Category: Vegetable; Grain;
Growth Stage During Space Flight: Seedling;
●Gravitational pull - Gravitropism
 ●n.a.
 ●Growth - Seed germination ---> Epicotyls extensibility
●Growth - Seed germination ---> Coleoptiles extensibility
●Growth - Seed germination ---> Epicotyls direction
●Growth - Seed germination ---> Epicotyls angle
●Component - Plant hormone ---> Auxin
SLID-169 Polar auxin transport is essential to maintain growth and development of etiolated pea and maize seedlings grown under 1 g conditions: Relevance to the international space station experiment Investigated Organism: Pisum sativum; Zea mays;
Organism Common Name: Pea; Maize;
Organism Class: Food;
Studied Organ/Tissue/Part: Seedling; Epicotyls; Coleoptile;
Food Category: Vegetable; Grain;
Growth Stage During Space Flight: Seedling;
●Gravitational pull - Gravitropism
 ●n.a.
 ●Growth - Seed germination ---> Coleoptile length
●Growth - Seed germination ---> Mesocotyls length
●Component - Plant hormone ---> Auxin
SLID-170 A novel maize dwarf mutant generated by Ty1-copia LTR-retrotransposon insertion in Brachytic2 after spaceflight Investigated Organism: Zea mays;
Organism Common Name: Maize;
Organism Class: Food;
Studied Organ/Tissue/Part: Seed; Ear;
Food Category: Grain;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Growth - Stem and branch ---> Ear height
●Growth - Stem and branch ---> Cell length
●Growth - Stem and branch ---> Total cell number per internode
●Growth - Fruit and seed ---> Seed-setting rate
●Omics - Genetics and breeding ---> Polymorphic sites
●Omics - Genetics and breeding ---> Allelic mutations
●Omics - Genetics and breeding ---> Retrotransposon insertion
●Quality - Yield
SLID-171 Genome-wide expression analysis of reactive oxygen species gene network in Mizuna plants grown in long-term spaceflight Investigated Organism: Brassica rapa (Mizuna);
Organism Common Name: n.a.;
Organism Class: Food;
Studied Organ/Tissue/Part: Leaf;
Food Category: Vegetable;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Omics - Transcriptomics ---> Leaf
●Omics - Transcriptomics of stress resistance ---> ROS oxidative marker gene expression
●Omics - Transcriptomics of stress resistance ---> ROS scavenging response
SLID-172 Gravity-regulated localization of PsPIN1 is important for polar auxin transport in etiolated pea seedlings: Relevance to the International Space Station experiment Investigated Organism: Pisum sativum;
Organism Common Name: Pea;
Organism Class: Food;
Studied Organ/Tissue/Part: Seedling;
Food Category: Vegetable;
Growth Stage During Space Flight: Seedling;
●Gravitational pull - Gravitropism
 ●n.a.
 ●Component - Plant hormone ---> Auxin
●Component - Plant hormone ---> Auxin transport protein
SLID-173 Spaceflight effects on consecutive generations of peas grown onboard the Russian segment of the International Space Station Investigated Organism: Pisum sativum;
Organism Common Name: Pea;
Organism Class: Food;
Studied Organ/Tissue/Part: Whole plant; Seed; Root;
Food Category: Vegetable;
Growth Stage During Space Flight: Seed to seed;
●n.a.
 ●n.a.
 ●Growth - Fruit and seed ---> Pods per plant
●Growth - Fruit and seed ---> Seeds per plant
●Omics - Genetics and breeding ---> Chromosomal aberrations count
●Quality - Yield
SLID-174 Microbiological and Nutritional Analysis of Lettuce Crops Grown on the International Space Station Investigated Organism: Lactuca sativa;
Organism Common Name: Red romaine lettuce;
Organism Class: Food;
Studied Organ/Tissue/Part: Leaf; Root;
Food Category: Vegetable;
Growth Stage During Space Flight: Seed to mature plant;
●n.a.
 ●n.a.
 ●Omics - Microbiota ---> Species composition
●Omics - Microbiota ---> Species diversity
●Component - Mineral elements
SLID-175 Growth regulation mechanisms in higher plants under microgravity conditions - changes in cell wall metabolism Investigated Organism: Arabidopsis thaliana; Oryza sativa;
Organism Common Name: Thale cress; Rice;
Organism Class: Model organism; Food;
Studied Organ/Tissue/Part: Coleoptile; Hypocotyl;
Food Category: Grain; n.a.;
Growth Stage During Space Flight: Seedling;
●Gravitational pull - Gravitropism
 ●n.a.
 ●Growth - Seed germination ---> Coleoptile length
●Growth - Seed germination ---> Hypocotyl length
●Growth - Seed germination ---> Coleoptiles extensibility
●Component - Plant hormone ---> Auxin
●Component - Cell wall ---> Cell wall enzyme activity
●Component - Cell wall ---> Cell wall extensibility
●Component - Cell wall ---> Cell wall polysaccharides
SLID-176 Growth and cell wall changes in rice roots during spaceflight Investigated Organism: Oryza sativa;
Organism Common Name: Rice;
Organism Class: Food; Model organism;
Studied Organ/Tissue/Part: Root;
Food Category: Grain;
Growth Stage During Space Flight: Seedling;
●Gravitational pull - Gravitropism
 ●n.a.
 ●Growth - Root ---> Root length
●Growth - Root ---> Root angle
●Component - Cell wall ---> Cell wall polysaccharides
●Component - Cell wall ---> Polysaccharides level
SLID-177 Analysis of cytogenetic damage in rice seeds induced by energetic heavy ions on-ground and after spaceflight Investigated Organism: Oryza sativa;
Organism Common Name: Rice;
Organism Class: Food; Model organism;
Studied Organ/Tissue/Part: Root tip;
Food Category: Grain;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Growth - Root ---> Mitosis index
●Process - DNA damage ---> Micronucleus
●Process - DNA damage ---> Cytogenetic damage
SLID-178 Diversity and Stability Study on Rice Mutants Induced in Space Environment Investigated Organism: Oryza sativa;
Organism Common Name: Rice;
Organism Class: Food; Model organism;
Studied Organ/Tissue/Part: Leaf;
Food Category: Grain;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Omics - Proteome ---> Leaf
●Component - Proteins
SLID-179 Comparison of space flight and heavy ion radiation induced genomic/epigenomic mutations in rice (Oryza sativa) Investigated Organism: Oryza sativa;
Organism Common Name: Rice;
Organism Class: Food; Model organism;
Studied Organ/Tissue/Part: Leaf;
Food Category: Grain;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Omics - Genetics and breeding ---> Polymorphic sites
●Omics - Genetics and breeding ---> Mutation rate
●Omics - Genetics and breeding ---> Mutation heritability
●Omics - Epigenome
SLID-180 Gene expression of rice seeds surviving 13- and 20-month exposure to space environment Investigated Organism: Oryza sativa;
Organism Common Name: Rice;
Organism Class: Food; Model organism;
Studied Organ/Tissue/Part: Seed; Root; Shoot;
Food Category: Grain;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Omics - Transcriptomics ---> Dry seeds
●Omics - Transcriptomics ---> Germinated seed
●Omics - Transcriptomics ---> Roots
●Omics - Transcriptomics ---> Shoots
●Omics - Genetics and breeding ---> Mutation rate
●Omics - Genetics and breeding ---> Allelic mutations
SLID-181 Proteomic analysis in different development stages on SP0 generation of rice seeds after space flight Investigated Organism: Oryza sativa;
Organism Common Name: Rice;
Organism Class: Food; Model organism;
Studied Organ/Tissue/Part: Leaf;
Food Category: Grain;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Growth - Seed germination ---> Germination rate
●Growth - Stem and branch ---> Tiller number
●Process - Stress resistance ---> Reactive oxygen species resistance
SLID-182 Space environment induced mutations prefer to occur at polymorphic sites of rice genomes Investigated Organism: Oryza sativa;
Organism Common Name: Rice;
Organism Class: Food; Model organism;
Studied Organ/Tissue/Part: Leaf;
Food Category: Grain;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Process - Stress resistance ---> Rice blast resistance
●Omics - Genetics and breeding ---> Polymorphic sites
●Omics - Genetics and breeding ---> Mutation rate
SLID-183 Transcriptomic analyses of space-induced rice mutants with enhanced susceptibility to rice blast Investigated Organism: Oryza sativa;
Organism Common Name: Rice;
Organism Class: Food; Model organism;
Studied Organ/Tissue/Part: Leaf;
Food Category: Grain;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Process - Stress resistance ---> Susceptibility to rice blast
●Component - Plant hormone ---> Hormone metabolism
●Omics - Transcriptomics ---> Seedling leaf
●Component - Cell wall ---> Cell wall structure
●Environment - Simulated microgravity
SLID-184 Proteomic analysis of high yield rice variety mutated from spaceflight Investigated Organism: Oryza sativa;
Organism Common Name: Rice;
Organism Class: Food; Model organism;
Studied Organ/Tissue/Part: Leaf;
Food Category: Grain;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Omics - Proteome ---> Leaf
●Component - Proteins
SLID-185 Characteristics of phenotype and genetic mutations in rice after spaceflight Investigated Organism: Oryza sativa;
Organism Common Name: Rice;
Organism Class: Food; Model organism;
Studied Organ/Tissue/Part: Whole plant; Leaf;
Food Category: Grain;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Growth - Whole plant ---> Plant hight
●Growth - Fruit and seed ---> Spike length
●Growth - Fruit and seed ---> Mature grains per spike
●Growth - Fruit and seed ---> Seed rate
●Omics - Genetics and breeding ---> Mutation rate
●Quality - Yield
SLID-186 A Comparative Study on Mutagenic Effects of Space Flight and Irradiation of γ-rays on Rice Investigated Organism: Oryza sativa;
Organism Common Name: Rice;
Organism Class: Food; Model organism;
Studied Organ/Tissue/Part: Seed; Seedling;
Food Category: Grain;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Growth - Seed germination ---> Seedling height
●Growth - Fruit and seed ---> Seed fertility
SLID-187 Xylem development and cell wall changes of soybean seedlings grown in space Investigated Organism: Glycine max;
Organism Common Name: Soybean;
Organism Class: Food; Herb;
Studied Organ/Tissue/Part: Hypocotyl; Cotyledon;
Food Category: Grain;
Growth Stage During Space Flight: Seedling;
●Gravitational pull - Gravitropism
 ●n.a.
 ●Growth - Xylem ---> Cellulose microfibrils
●Growth - Xylem ---> Vessel wall thickness
SLID-188 Growth patterns for etiolated soybeans germinated under spaceflight conditions Investigated Organism: Glycine max;
Organism Common Name: Soybean;
Organism Class: Food; Herb;
Studied Organ/Tissue/Part: Root;
Food Category: Grain;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Growth - Root ---> Primary root length
●Growth - Root ---> Lateral root length
●Component - Plant hormone ---> Ethylene
●Environment - Simulated microgravity
SLID-189 Comparative floral development of Mir-grown and ethylene-treated, earth-grown Super Dwarf wheat Investigated Organism: Triticum aestivum (Super Dwarf wheat);
Organism Common Name: n.a.;
Organism Class: Food;
Studied Organ/Tissue/Part: Whole plant; Flower;
Food Category: Grain;
Growth Stage During Space Flight: Seed to mature plant;
●n.a.
 ●n.a.
 ●Growth - Whole plant ---> Plant hight
●Growth - Flower ---> Anther morphology
●Growth - Flower ---> Florets per spikelet
●Growth - Flower ---> Pollen produce
●Growth - Stem and branch ---> Tiller number
●Growth - Fruit and seed ---> Awn length
●Growth - Fruit and seed ---> Rachis nodes per spike
●Growth - Fruit and seed ---> Spike length
●Component - Plant hormone ---> Ethylene
●Quality - Yield
SLID-190 Effects of spaceflight and simulated microgravity on cell sub-microstructure and antioxidant enzyme activity in tomato Investigated Organism: Solanum lycopersicum;
Organism Common Name: Tomato;
Organism Class: Food;
Studied Organ/Tissue/Part: Leaf; Fruit;
Food Category: Fruit;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Process - Photosynthesis ---> Chloroplasts structure
●Growth - Fruit and seed ---> Fruit bearing rate
●Growth - Fruit and seed ---> Fruit maximum diameter
●Quality - Yield
●Environment - Simulated microgravity
SLID-191 Physical, chemical and biological characteristics of space flown tomato ( Lycopersicum esculentum ) seeds Investigated Organism: Solanum lycopersicum;
Organism Common Name: Tomato;
Organism Class: Food;
Studied Organ/Tissue/Part: Seed; Whole plant;
Food Category: Fruit;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Growth - Whole plant ---> Plant hight
●Component - Plant hormone ---> Cytokinin
●Component - Plant hormone ---> Cibberellin
●Component - Plant hormone ---> Auxin
●Component - Carbohydrate
●Component - Mineral elements
SLID-192 The effects of spaceflight on soluble protein, isoperoxidase, and genomic DNA in ural licorice (Glycyrrhiza uralensis fisch.) Investigated Organism: Glycyrrhiza uralensis;
Organism Common Name: Licorice;
Organism Class: Herb;
Studied Organ/Tissue/Part: Leaf;
Food Category: n.a.;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Process - Stress resistance ---> Ionizing radiation
●Process - Stress resistance ---> Peroxidase activity
●Component - Proteins
●Environment - Radiation
SLID-193 Transcriptome and proteomic analyses reveal multiple differences associated with chloroplast development in the spaceflight-induced wheat albino mutant mta Investigated Organism: Triticum aestivum (Wheat);
Organism Common Name: n.a.;
Organism Class: Food;
Studied Organ/Tissue/Part: Leaf;
Food Category: Grain;
Growth Stage During Space Flight: Seed;
●Light absorption and electron transfer - Photosynthesis
 ●n.a.
 ●Process - Photosynthesis ---> Chloroplast development
●Process - Photosynthesis ---> Chloroplast morphology
●Process - Photosynthesis ---> Chlorophyll content
●Process - Photosynthesis ---> Carotenoid content
●Omics - Transcriptomics ---> Leaf
●Omics - Proteome ---> Leaf
SLID-194 RNAseq analysis reveals pathways and candidate genes associated with salinity tolerance in a spaceflight-induced wheat mutant Investigated Organism: Triticum aestivum (Wheat);
Organism Common Name: n.a.;
Organism Class: Food;
Studied Organ/Tissue/Part: Shoot;
Food Category: Grain;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Omics - Transcriptomics ---> Shoot
●Process - Stress resistance ---> Salinity stress
SLID-195 Characterization of a Novel Chlorophyll-Deficient Mutant Mt6172 in Wheat Investigated Organism: Triticum aestivum (Wheat);
Organism Common Name: n.a.;
Organism Class: Food;
Studied Organ/Tissue/Part: Seedling; Leaf; Root;
Food Category: Grain;
Growth Stage During Space Flight: Seed;
●Light absorption and electron transfer - Photosynthesis
 ●n.a.
 ●Growth - Seed germination ---> Seedling height
●Growth - Seed germination ---> Root length
●Growth - Root ---> Root length
●Process - Photosynthesis ---> Chloroplast morphology
●Process - Photosynthesis ---> Electron transport rate
●Process - Photosynthesis ---> Maximum photosystem II
SLID-196 A spaceflight experiment for the study of gravimorphogenesis and hydrotropism in cucumber seedlings Investigated Organism: Cucumis sativus;
Organism Common Name: Cucumber;
Organism Class: Food;
Studied Organ/Tissue/Part: Root;
Food Category: Vegetable;
Growth Stage During Space Flight: Seedling;
●Gravitational pull - Gravitropism
 ●n.a.
 ●Growth - Root ---> Hydrotropism
●Growth - Root ---> Gravitropism
●Component - Plant hormone ---> Auxin
SLID-197 Gravitropism interferes with hydrotropism via counteracting auxin dynamics in cucumber roots: clinorotation and spaceflight experiments Investigated Organism: Cucumis sativus;
Organism Common Name: Cucumber;
Organism Class: Food;
Studied Organ/Tissue/Part: Root;
Food Category: Vegetable;
Growth Stage During Space Flight: Seedling;
●Gravitational pull - Gravitropism
 ●n.a.
 ●Growth - Root ---> Hydrotropism
●Growth - Root ---> Gravitropism
●Component - Plant hormone ---> Auxin
●Component - Plant hormone ---> Auxin transport protein
SLID-198 The gravity-induced re-localization of auxin efflux carrier CsPIN1 in cucumber seedlings: spaceflight experiments for immunohistochemical microscopy Investigated Organism: Cucumis sativus;
Organism Common Name: Cucumber;
Organism Class: Food;
Studied Organ/Tissue/Part: Hypocotyl;
Food Category: Vegetable;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Component - Plant hormone ---> Auxin
●Component - Plant hormone ---> Auxin transport protein
SLID-199 Molecular Cytogenetics of Pisum sativum L. Grown under Spaceflight-Related Stress Investigated Organism: Pisum sativum;
Organism Common Name: Pea;
Organism Class: Food;
Studied Organ/Tissue/Part: Root tip;
Food Category: Vegetable;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Omics - Genetics and breeding ---> Chromosome structural changes
SLID-200 Spaceflight induces both transient and heritable alterations in DNA methylation and gene expression in rice (Oryza sativa L.) Investigated Organism: Oryza sativa;
Organism Common Name: Rice;
Organism Class: Food; Model organism;
Studied Organ/Tissue/Part: Leaf;
Food Category: Grain;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Omics - Genetics and breeding ---> Transposable elements
●Omics - Epigenome ---> Leaf
SLID-201 The spaceflight environment can induce transpositional activation of multiple endogenous transposable elements in a genotype-dependent manner in rice Investigated Organism: Oryza sativa;
Organism Common Name: Rice;
Organism Class: Food; Model organism;
Studied Organ/Tissue/Part: Leaf;
Food Category: Grain;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Omics - Genetics and breeding ---> Genetic instability
●Omics - Genetics and breeding ---> Transposable elements
●Omics - Transcriptomics ---> Leaf
SLID-202 Spaceflight-induced genetic and epigenetic changes in the rice (Oryza sativa L.) genome are independent of each other Investigated Organism: Oryza sativa;
Organism Common Name: Rice;
Organism Class: Food; Model organism;
Studied Organ/Tissue/Part: Leaf;
Food Category: Grain;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Omics - Genetics and breeding ---> Transposable elements
●Omics - Genetics and breeding ---> Mutation rate
●Omics - Genetics and breeding ---> Heritable epigenetic changes
●Omics - Epigenome ---> Leaf
SLID-203 Rocket Science: The Effect of Spaceflight on Germination Physiology, Ageing, and Transcriptome of Eruca sativa Seeds Investigated Organism: Eruca vesicaria subsp. sativa;
Organism Common Name: Salad rocket;
Organism Class: Food;
Studied Organ/Tissue/Part: Seed;
Food Category: Vegetable;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Growth - Seed germination ---> Seed conductivity
●Growth - Ageing
●Omics - Transcriptomics ---> Seed
SLID-204 Morphological variation of mutant sunflowers (Helianthus annuus) induced by space flight and their genetic background detection by SSR primers Investigated Organism: Helianthus annuus;
Organism Common Name: Sunflower;
Organism Class: Garden plant; Food;
Studied Organ/Tissue/Part: Leaf; Flower; Seed;
Food Category: Oil crop;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Growth - Flower ---> Flower color
●Growth - Flower ---> Ligulate petals shape
●Omics - Genetics and breeding ---> Mutation
●Omics - Genetics and breeding ---> Sterile plants
SLID-205 Analysis of the Spaceflight Effects on Growth and Development of Super Dwarf Wheat Grown on the Space Station Mir Investigated Organism: Triticum aestivum (Super Dwarf wheat);
Organism Common Name: n.a.;
Organism Class: Food;
Studied Organ/Tissue/Part: Whole plant; Flower;
Food Category: Grain;
Growth Stage During Space Flight: Seed to mature plant;
●n.a.
 ●n.a.
 ●Growth - Whole plant ---> Plant biomass
●Growth - Stem and branch ---> Tillers per spikelet
●Growth - Stem and branch ---> Stem length
●Growth - Flower ---> Florets per spikelet
●Growth - Flower ---> Pollination
●Growth - Fruit and seed ---> Spike mass
●Growth - Fruit and seed ---> Awn length
●Growth - Fruit and seed ---> Spikelets per spike
●Growth - Fruit and seed ---> Seeds per spike
●Quality - Yield
●Component - Plant hormone ---> Auxin
SLID-206 Effects of Exposure in Space on Tomato Seeds: Photosynthesis, Biomass, and Water Relations of Well-Watered and Drought-Stressed Plants Investigated Organism: Solanum lycopersicum;
Organism Common Name: Tomato;
Organism Class: Food;
Studied Organ/Tissue/Part: Whole plant; Seed;
Food Category: Fruit;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Growth - Whole plant ---> Plant biomass
●Growth - Fruit and seed ---> Fruit production
●Process - Stress resistance ---> Drought stress
●Process - Stress resistance ---> Water relations
●Quality - Yield
●Process - Photosynthesis
SLID-207 Effect of spaceflight duration of subcellular morphologies and defense enzyme activities in earth-grown tomato seedlings propagated from space-flown seeds Investigated Organism: Solanum lycopersicum;
Organism Common Name: Tomato;
Organism Class: Food;
Studied Organ/Tissue/Part: Leaf;
Food Category: Fruit;
Growth Stage During Space Flight: Seed;
●Light absorption and electron transfer - Photosynthesis - Chloroplasts
 ●n.a.
 ●Process - Stress resistance ---> Defense enzyme activity
●Process - Photosynthesis ---> Chloroplasts structure
●Process - Energy metabolism ---> Mitochondria structure
SLID-208 Effects of a spaceflight environment on heritable changes in wheat gene expression Investigated Organism: Triticum aestivum (Wheat);
Organism Common Name: n.a.;
Organism Class: Food;
Studied Organ/Tissue/Part: Leaf;
Food Category: Grain;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Omics - Transcriptomics ---> Leaf
●Omics - Genetics and breeding ---> Heritable gene expression changes
SLID-209 Effects of space flight on Xenopus laevis larval development Investigated Organism: Xenopus laevis;
Organism Common Name: African Clawed Frog;
Organism Class: Amphibian;
Studied Organ/Tissue/Part: Embryos;
●n.a.
 ●n.a.
 ●Development and Reproduction - Development ---> Notochord deformity
●Development and Reproduction - Development ---> Muscle fiber density
●Development and Reproduction - Development ---> Smaller lungs
●Development and Reproduction - Development ---> Caudal deformity
SLID-210 Altered gravitational forces affect the development of the static vestibuloocular reflex in fish (Oreochromis mossambicus) Investigated Organism: Oreochromis mossambicus;
Organism Common Name: Mozambique tilapia;
Organism Class: Fish;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●n.a.
 ●Development and Reproduction - Development ---> Morphological development acceleration
●Nervous and regulatory systems - Neuro-sensory function ---> Static vestibuloocular reflex
●Environment - Hypergravity
SLID-211 Effects of microgravity on the larval development, metamorphosis and reproduction of the urodele amphibian Pleurodeles waltl Investigated Organism: Pleurodeles waltl;
Organism Common Name: Newt;
Organism Class: Amphibian;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●n.a.
 ●Development and Reproduction - Development ---> Metamorphosis
●Development and Reproduction - Development ---> Fertilization
●Development and Reproduction - Development ---> Embryonic development
SLID-212 Fertilization of frog eggs on a sounding rocket in space Investigated Organism: Xenopus laevis;
Organism Common Name: African Clawed Frog;
Organism Class: Amphibian;
Studied Organ/Tissue/Part: Egg;
●n.a.
 ●n.a.
 ●Development and Reproduction - Reproduction ---> Fertilization
●Development and Reproduction - Reproduction ---> Egg surface structures
SLID-213 Embryogenesis and organogenesis of Carausius morosus under spaceflight conditions Investigated Organism: Carausius morosus;
Organism Common Name: Indian stick insect;
Organism Class: Arthropod;
Studied Organ/Tissue/Part: Egg;
●n.a.
 ●n.a.
 ●Development and Reproduction - Development ---> Embryogenesis
●Development and Reproduction - Development ---> Organogenesis
●Development and Reproduction - Development ---> Hatching rates
●Development and Reproduction - Development ---> Growth kinetics
●Development and Reproduction - Development ---> Anomaly frequencies
●Environment - Radiation
SLID-214 Space flight experiment on chinese silkworm on board the russian 10th biosatellite Investigated Organism: Bombyx mori;
Organism Common Name: Chinese silkworm;
Organism Class: Arthropod;
Studied Organ/Tissue/Part: Pupae; Egg; Cocoons; Larvae; Moths;
●n.a.
 ●Aging
 ●Development and Reproduction - Reproduction ---> Oviposition
●Development and Reproduction - Reproduction ---> Hatching
●Omics - DNA damage ---> Mutation
SLID-215 Development and swimming behavior of Medaka fry in a spaceflight aboard the Space Shuttle Columbia (STS-107) Investigated Organism: Oryzias latipes;
Organism Common Name: Medaka fish;
Organism Class: Fish;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●n.a.
 ●Nervous and regulatory systems - Behavior ---> Swimming behavior
●Nervous and regulatory systems - Behavior ---> Posture control
●Nervous and regulatory systems - Neuromotor control
SLID-216 Tardigrades survive exposure to space in low Earth orbit Investigated Organism: Richtersius coronifer;
Organism Common Name: Water bear;
Organism Class: Tardigrada;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●n.a.
 ●Other profiles - Survive
●Environment - Vacuum
●Environment - Radiation
SLID-217 Biochemical and Molecular Biological Analyses of space-flown nematodes in Japan, the First International Caenorhabditis elegans Experiment (ICE-First) Investigated Organism: Caenorhabditis elegans;
Organism Common Name: Nematode;
Organism Class: Worm;
Studied Organ/Tissue/Part: Muscle; Germ cell;
●n.a.
 ●n.a.
 ●Development and Reproduction - Reproduction ---> Meiotic chromosomal dynamics
●Development and Reproduction - Development ---> Muscle cell development
●Other profiles - Cell physiology ---> Apoptosis
●Other profiles - Cell physiology ---> Protein aggregation
SLID-218 Tardigrade Resistance to Space Effects: first results of experiments on the LIFE-TARSE mission on FOTON-M3 (September 2007) Investigated Organism: Macrobiotus richtersi;
Organism Common Name: Water bear;
Organism Class: Tardigrada;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●n.a.
 ●Other profiles - Survive
●Omics - DNA damage ---> DNA integrity
●Development and Reproduction - Reproduction ---> Oviposition
SLID-219 Innate immune responses of Drosophila melanogaster are altered by spaceflight Investigated Organism: Drosophila melanogaster;
Organism Common Name: Fruit fly;
Organism Class: Arthropod;
Studied Organ/Tissue/Part: Whole animal; Hemocytes;
●n.a.
 ●n.a.
 ●Cardiovascular and Immune System - Immune function ---> Plasmatocyte number
●Cardiovascular and Immune System - Immune function ---> Plasmatocyte activity
●Cardiovascular and Immune System - Immune function ---> Bacterial clearance
●Omics - Transcriptome
SLID-220 Effect of spaceflight on the circadian rhythm, lifespan and gene expression of Drosophila melanogaster Investigated Organism: Drosophila melanogaster;
Organism Common Name: Fruit fly;
Organism Class: Arthropod;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●Aging
 ●Cardiovascular and Immune System - Circadian rhythm ---> Circadian clock
●Nervous and regulatory systems - Behavior ---> Locomotor activity
●Nervous and regulatory systems - Behavior ---> Sleep pattern
●Omics - Transcriptome
SLID-221 The Development Of Drosophila Melanogaster under Different Duration Space Flight and Subsequent Adaptation to Earth Gravity Investigated Organism: Drosophila melanogaster;
Organism Common Name: Fruit fly;
Organism Class: Arthropod;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●n.a.
 ●Development and Reproduction - Development ---> Morphogenesis
●Development and Reproduction - Development ---> Cell differentiation
●Other profiles - Cell physiology ---> Cytoskeletal organization
SLID-222 Individual features of play behavior in thick-toed geckos in weightlessness and normal gravity conditions Investigated Organism: Chondrodactylus turneri;
Studied Organism Strains: Chondrodactylus turneri GRAY, 1864;
Organism Common Name: Thick-toed gecko;
Organism Class: Reptile;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●n.a.
 ●Nervous and regulatory systems - Behavior ---> Play behavior
SLID-223 Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6N;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone; Muscle; Blood;
●n.a.
 ●Bone loss
●Muscle atrophy
 ●Musculoskeletal system - Bone properties ---> Bone homeostasis
●Musculoskeletal system - Muscle properties ---> Muscle mass
●Musculoskeletal system - Muscle properties ---> Muscle homeostasis
●Omics - Transcriptome ---> Bone
●Omics - Transcriptome ---> Muscle
●Omics - Proteome ---> Blood
SLID-224 Object play in thick-toed geckos during a space experiment Investigated Organism: Chondrodactylus turneri;
Studied Organism Strains: Chondrodactylus turneri GRAY, 1864;
Organism Common Name: Thick-toed gecko;
Organism Class: Reptile;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●n.a.
 ●Nervous and regulatory systems - Behavior ---> Play behavior
SLID-225 Fish Inner Ear Otolith Growth Under Real Microgravity (Spaceflight) and Clinorotation Investigated Organism: Oreochromis mossambicus;
Organism Common Name: Mozambique tilapia;
Organism Class: Fish;
Studied Organ/Tissue/Part: Vestibular organs; Whole animal;
●Inertial forces - Otolith system
 ●n.a.
 ●Development and Reproduction - Development ---> Otoliths biomineralization
●Nervous and regulatory systems - Behavior ---> Swimming behavior
●Nervous and regulatory systems - Neuromotor control
●Environment - Simulated microgravity
SLID-226 Spaceflight results in increase of thick filament but not thin filament proteins in the paramyosin mutant of Caenorhabditis elegans Investigated Organism: Caenorhabditis elegans;
Organism Common Name: Nematode;
Organism Class: Worm;
Studied Organ/Tissue/Part: Muscle;
●n.a.
 ●n.a.
 ●Musculoskeletal system - Muscle properties ---> Mutant
●Musculoskeletal system - Muscle properties ---> Muscle proteins
●Musculoskeletal system - Muscle properties ---> Muscle fiber size
●Musculoskeletal system - Muscle properties ---> Function compensate
SLID-227 Development of mouse preimplantation embryos in space Investigated Organism: Mus musculus;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Embryos;
●n.a.
 ●Development impairment
 ●Development and Reproduction - Development ---> Blastocyst quality
●Development and Reproduction - Development ---> Blastocyst formation
●Omics - DNA damage
●Omics - Epigenome ---> Embryos
SLID-228 Extreme stress tolerance in tardigrades: surviving space conditions in low earth orbit Investigated Organism: Richtersius coronifer;
Organism Common Name: Water bear;
Organism Class: Tardigrada;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●n.a.
 ●Environment - Radiation
●Environment - Vacuum
●Other profiles - Survive ---> Anhydrobiosis
SLID-229 Spider Web-Building in Outer Space: Evaluation of Records from the Skylab Spider Experiment Investigated Organism: Araneus diadematus;
Organism Common Name: European garden spider;
Organism Class: Arthropod;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●n.a.
 ●Nervous and regulatory systems - Behavior ---> Web-building
SLID-230 Nematode Muscles Project in Spaceflight Experiment Investigated Organism: Caenorhabditis elegans;
Organism Common Name: Nematode;
Organism Class: Worm;
Studied Organ/Tissue/Part: Muscle;
●n.a.
 ●n.a.
 ●Musculoskeletal system - Muscle properties ---> Muscle protein
●Musculoskeletal system - Muscle properties ---> Mitochondrial network
SLID-231 Influence of long-term altered gravity on the swimming performance of developing cichlid fish: Including results from the 2nd German Spacelab Mission D-2 Investigated Organism: Oreochromis mossambicus;
Organism Common Name: Mozambique tilapia;
Organism Class: Fish;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●n.a.
 ●Development and Reproduction - Development
●Nervous and regulatory systems - Behavior ---> Somersaulting
●Nervous and regulatory systems - Behavior ---> Looping
●Nervous and regulatory systems - Behavior ---> Disorientated movements
●Nervous and regulatory systems - Behavior ---> Escape reaction
●Nervous and regulatory systems - Neuro-sensory function ---> Vestibular adaptation
SLID-232 Effect of 12-Day Spaceflight on Brain of Thick-Toed Geckos Investigated Organism: Chondrodactylus turneri;
Organism Common Name: Thick-toed gecko;
Organism Class: Reptile;
Studied Organ/Tissue/Part: Brain;
●n.a.
 ●n.a.
 ●Other profiles - Cell physiology ---> Cellular protein expression
SLID-233 Effect of potassium citrate therapy on the risk of renal stone formation during spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Urine;
●n.a.
 ●Renal stone
 ●Digestive and Excretory System - Excretory function ---> Renal stone formation
●Digestive and Excretory System - Excretory function ---> Uric acid supersaturation
●Other profiles - Medication use ---> Potassium citrate therapy
SLID-234 The State of the Digestive Organs during Long Spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Multiple organs;
●n.a.
 ●n.a.
 ●Other profiles - Organ morphology ---> Parenchymatous organ size
●Other profiles - Organ morphology ---> Parenchymatous organ echogenicity
●Other profiles - Organ morphology ---> Hollow organ wall
SLID-235 Stability of chromosome aberrations in the blood lymphocytes of astronauts measured after space flight by FISH chromosome painting Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Blood;
●n.a.
 ●Radiation damage
 ●Omics - DNA damage ---> Chromosome aberrations
SLID-236 Biochemical Markers of Bone Tissue Metabolism in Cosmonauts after a Prolonged Spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Blood;
●n.a.
 ●Bone loss
 ●Cardiovascular and Immune System - Blood components ---> Ionized calcium
●Cardiovascular and Immune System - Blood components ---> Parathyroid hormone
●Cardiovascular and Immune System - Blood components ---> Calcitonin
●Cardiovascular and Immune System - Blood components ---> Calcium homeostasis
●Nervous and regulatory systems - Endocrine function ---> Hormonal regulation
SLID-237 Prevalence of sleep deficiency and use of hypnotic drugs in astronauts before, during, and after spaceflight: an observational study Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Behavior;
●n.a.
 ●Sleeplessness
 ●Nervous and regulatory systems - Sleep ---> Nervous and regulatory systems - Sleep deficiency
●Other profiles - Medication use ---> Hypnotic drug
SLID-238 Brain structural plasticity with spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Brain;
●Fluid dynamics - Hemodynamics
 ●Brain damage
 ●Nervous and regulatory systems - Brain structure ---> Gray matter volume
●Nervous and regulatory systems - Brain structure ---> White matter volume
SLID-239 Gene-metabolite profile integration to understand the cause of spaceflight induced immunodeficiency Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Endothelial cells;
●n.a.
 ●Immune system dysregulation
 ●Cardiovascular and Immune System - Immune function ---> Immunodeficiency
SLID-240 High intensity training during spaceflight: results from the NASA Sprint Study Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Behavior; Bone;
●n.a.
 ●Bone loss
 ●Musculoskeletal system - Bone properties ---> Bone mineral density
●Other profiles - Medication use ---> Exercise
SLID-241 Quantitative magnetic resonance image assessment of the optic nerve and surrounding sheath after spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Behavior;
●Fluid dynamics - Hemodynamics
 ●Neuro-ocular syndrome
 ●Nervous and regulatory systems - Neuro-sensory function ---> Optic nerve deviation
●Nervous and regulatory systems - Neuro-sensory function ---> Optic nerve sheath cross-sectional areas
SLID-242 Vestibulo-oculomotor testing during the course of a spaceflight mission Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Vestibular system; Behavior;
●Inertial forces - Otolith system
 ●Neurovestibular decline
 ●Nervous and regulatory systems - Neuro-sensory function ---> Vestibulo-oculomotor response
SLID-243 Vestibular plasticity following orbital spaceflight: recovery from postflight postural instability Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Behavior; Vestibular system;
●n.a.
 ●Sensorimotor decline
 ●Nervous and regulatory systems - Neuro-sensory function ---> Vestibular plasticity
●Nervous and regulatory systems - Neuro-sensory function ---> Sensory organization
●Nervous and regulatory systems - Neuromotor control ---> Sensori-motor postural control
SLID-244 Impairments of manual tracking performance during spaceflight are associated with specific effects of microgravity on visuomotor transformations Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Behavior;
●n.a.
 ●Sensorimotor decline
 ●Nervous and regulatory systems - Neuromotor control ---> Manual tracking performance
●Nervous and regulatory systems - Neuromotor control ---> Visuomotor transformations
SLID-245 Hematopoietic stem cells and lineage cells undergo dynamic alterations under microgravity and recovery conditions Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Blood;
●n.a.
 ●Immune system dysregulation
 ●Cardiovascular and Immune System - Immune function ---> Blood lineage cells population
●Cardiovascular and Immune System - Immune function ---> Hematopoietic stem cell differentiation
SLID-246 Persistent Globe Flattening in Astronauts following Long-Duration Spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Eye;
●Fluid dynamics - Hemodynamics
 ●Visual impairment
 ●Nervous and regulatory systems - Eye properties ---> Scleral remodelling
●Nervous and regulatory systems - Eye properties ---> Globe flattening
SLID-247 Resilient microorganisms in dust samples of the International Space Station-survival of the adaptation specialists Investigated Organism: Microbiota;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria/Fungus;
Microbe Type: Microbiota;
Microbe Form: Spacecraft sample;
●n.a.
 ●Antibiotic resistance
 ●Omics - Microbiome ---> International space station dust sample
●Stress resistance - Heat shock resistance
●Other profiles - Microbial colonization on space crafts
●Omics - Spacecraft microbiome monitoring
SLID-248 Effect of space flight factors on alfalfa seeds Investigated Organism: Medicago sativa;
Organism Common Name: Alfalfa;
Organism Class: Garden plant;
Studied Organ/Tissue/Part: Seed; Root;
Food Category: n.a.;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Growth - Seed germination ---> Germination potential
●Growth - Seed germination ---> Germination index
●Growth - Seed germination ---> Hard seeds percentage
●Growth - Seed germination ---> Mitosis index
●Growth - Seed germination ---> Abnormal cotyledon percentage) Growth - Stem and branch
●Growth - Root ---> Root length
●Omics - Genetics and breeding ---> Chromosome aberration rate
●Quality - Yield
SLID-249 Gravitropism of hypocotyls of wild-type and starch-deficient Arabidopsis seedlings in spaceflight studies Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Seed; Seedling;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●Gravitational pull - Gravitropism
 ●n.a.
 ●Growth - Seed germination ---> Germination rate
●Growth - Seed germination ---> Seedling length
●Growth - Seed germination ---> Hypocotyl hook morphology
●Growth - Root ---> Gravitropis
●Component - Plant hormone ---> Ethylene
●Environment - Simulated microgravity
SLID-250 An endogenous growth pattern of roots is revealed in seedlings grown in microgravity Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Seedling; Root;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●Gravitational pull - Gravitropism
 ●n.a.
 ●Growth - Seed germination ---> Germination rate
●Growth - Seed germination ---> Seedling length
●Growth - Root ---> Root angle
●Growth - Root ---> Adventitious roots
●Growth - Root ---> Gravitropism
SLID-251 Phototropism of Arabidopsis thaliana in microgravity and fractional gravity on the International Space Station Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Hypocotyl; Root;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●Gravitational pull - Gravitropism
 ●n.a.
 ●Growth - Root ---> Roots curvature
●Growth - Root ---> Gravitropism
●Process - Phototropism ---> Phytochrome mutants
●Process - Phototropism ---> Red light
●Process - Phototropism ---> Blue light
SLID-252 Plant growth strategies are remodeled by spaceflight Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Root;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●Gravitational pull - Gravitropism
 ●n.a.
 ●Growth - Seed germination ---> Hypocotyl length
●Growth - Root ---> Root length
●Growth - Root ---> Root deviation
●Growth - Root ---> Gravitropism
SLID-253 Transcriptome analyses of Arabidopsis thaliana seedlings grown in space: implications for gravity-responsive genes Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Seedling; Root;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●Gravitational pull - Gravitropism
 ●n.a.
 ●Omics - Transcriptomics ---> Seedling
●Growth - Root ---> Gravitropism
●Environment - Artificial gravity
SLID-254 Transcriptional response of Arabidopsis seedlings during spaceflight reveals peroxidase and cell wall remodeling genes associated with root hair development Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Seedling; Root;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Process - Stress resistance ---> Oxidative stress
●Growth - Root ---> Root hair length
●Component - Cell wall ---> Cell wall remodeling
SLID-255 Morphometric analyses of petioles of seedlings grown in a spaceflight experiment Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Seedling;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Growth - Seed germination ---> Germination rate
●Growth - Seed germination ---> Seedling length
●Growth - Seed germination ---> Cell plastids
SLID-256 Comparative transcriptomics indicate changes in cell wall organization and stress response in seedlings during spaceflight Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Shoot;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Process - Stress resistance ---> Hypoxia responses
●Process - Stress resistance ---> Heat shock response
●Process - Stress resistance ---> DNA repair
●Component - Cell wall ---> Cell wall structure
●Component - Cell wall ---> Cell wall components
●Component - Cell wall ---> Glycome profiling
●Omics - Transcriptomics ---> Shoot
SLID-257 The combined effects of real or simulated microgravity and red-light photoactivation on plant root meristematic cells Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Root;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●Gravitational pull - Gravitropism
 ●n.a.
 ●Process - Photoactivation ---> Cell growth and proliferation
●Process - Photoactivation ---> Red light
●Environment - Simulated microgravity
SLID-258 Single-base resolution methylome analysis shows epigenetic changes in Arabidopsis seedlings exposed to microgravity spaceflight conditions on board the SJ-10 recoverable satellite Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Leaf;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Growth - Leaf ---> Leaf sizes
●Omics - Epigenome ---> Leaf
SLID-259 Comparing RNA-Seq and microarray gene expression data in two zones of the Arabidopsis root apex relevant to spaceflight Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Root tip;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Omics - Transcriptomics ---> Root
SLID-260 Variation in the transcriptome of different ecotypes of Arabidopsis thaliana reveals signatures of oxidative stress in plant responses to spaceflight Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Seedling;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Process - Stress resistance ---> Oxidative stress
●Process - Stress resistance ---> Hypoxia responses
●Process - Stress resistance ---> H2O2 and hypoxic treatment
●Omics - Transcriptomics ---> RNA seq
SLID-261 Epigenomics in an extraterrestrial environment: organ-specific alteration of DNA methylation and gene expression elicited by spaceflight in Arabidopsis thaliana Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Seedling;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Omics - Transcriptomics of stress resistance ---> Spaceflight adaptation
●Omics - Epigenome ---> Seedling
●Omics - Transcriptomics ---> Seedling
SLID-262 Spaceflight-induced alternative splicing during seedling development in Arabidopsis thaliana Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Seedling;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Omics - Transcriptomics ---> Seedling
●Omics - Transcriptomics ---> Alternative splicing
SLID-263 Root Skewing-Associated Genes Impact the Spaceflight Response of Arabidopsis thaliana Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Root;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Omics - Transcriptomics of stress resistance ---> Spaceflight adaptation
●Growth - Root ---> Root length
●Growth - Root ---> Root angle
●Growth - Root ---> Root skewing
SLID-264 Spaceflight induces novel regulatory responses in Arabidopsis seedling as revealed by combined proteomic and transcriptomic analyses Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Seedling;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Omics - Proteome ---> Seedling
●Omics - Proteome ---> Protein phosphorylation
●Omics - Transcriptomics ---> Seedling
●Omics - Transcriptomics ---> Alternative splicing
SLID-265 Arabidopsis gene expression patterns are altered during spaceflight Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Seedling;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Omics - Transcriptomics of stress resistance ---> Heat shock response
●Omics - Transcriptomics ---> Seedling
SLID-266 Operations of a spaceflight experiment to investigate plant tropisms Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Seedling;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●Gravitational pull - Gravitropism
 ●n.a.
 ●Growth - Seed germination ---> Hypocotyls angle
●Growth - Seed germination ---> Gravitropism
●Growth - Seed germination ---> Phototropism
SLID-267 Assessment of genetic diversity and variation of Robinia pseudoacacia seeds induced by short-term spaceflight based on two molecular marker systems and morphological traits Investigated Organism: Robinia pseudoacacia;
Organism Common Name: Black locust;
Organism Class: Garden plant;
Studied Organ/Tissue/Part: Whole plant; Leaf;
Food Category: n.a.;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Growth - Stem and branch ---> Basal diameter
●Growth - Stem and branch ---> Branch number
●Growth - Stem and branch ---> Branch stipular thorn length
●Growth - Stem and branch ---> Branch stipular thorn middle width
●Growth - Leaf ---> Leaflet vertex angle
●Growth - Leaf ---> Tippy leaf vertex angle
●Omics - Genetics and breeding ---> Genetic diversity
●Omics - Genetics and breeding ---> Polymorphic sites
SLID-268 Gravity independence of seed-to-seed cycling in Brassica rapa Investigated Organism: Brassica rapa (Brassica);
Organism Common Name: n.a.;
Organism Class: Food;
Studied Organ/Tissue/Part: Whole plant; Cotyledon;
Food Category: Vegetable; Oil crop;
Growth Stage During Space Flight: Seed to seed;
●n.a.
 ●n.a.
 ●Growth - Whole plant ---> Plant hight
●Growth - Fruit and seed ---> Buds per plant
●Growth - Fruit and seed ---> Silique length
●Growth - Fruit and seed ---> Seed weight
●Growth - Fruit and seed ---> Embryo morphology
●Component - Glucosinolate
●Quality - Yield
SLID-269 Influence of microgravity on ultrastructure and storage reserves in seeds of Brassica rapa L Investigated Organism: Brassica rapa (Brassica);
Organism Common Name: n.a.;
Organism Class: Food;
Studied Organ/Tissue/Part: Seed; Cotyledon;
Food Category: Vegetable; Oil crop;
Growth Stage During Space Flight: Seed to seed;
●n.a.
 ●n.a.
 ●Growth - Fruit and seed ---> Seed weight
●Growth - Fruit and seed ---> Embryo morphology
●Growth - Fruit and seed ---> Seed size
●Component - Storage reserves ---> Protein bodies
●Component - Storage reserves ---> Starch
SLID-270 Analysis of influences of spaceflight on chemical constituents in licorice by HPLC–ESI-MS/MS Investigated Organism: Glycyrrhiza uralensis;
Organism Common Name: Licorice;
Organism Class: Food; Herb;
Studied Organ/Tissue/Part: Seed; Root;
Food Category: n.a.;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Growth - Seed germination ---> Hard seeds percentage
●Growth - Seed germination ---> Germinate power
●Component - Active ingredients ---> Liquiritin contents
●Component - Active ingredients ---> Glycyrrhizic acid contents
●Growth - Root ---> Root mass
●Growth - Root ---> Root length
●Quality - Yield
SLID-271 Spaceflight environment-induced variation in root yield and active constituents of Salvia miltiorrhiza Investigated Organism: Salvia miltiorrhiza;
Organism Common Name: Red sage;
Organism Class: Herb;
Studied Organ/Tissue/Part: Root;
Food Category: n.a.;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Growth - Root ---> Root mass
●Component - Active ingredients ---> Tanshinone contents
●Component - Active ingredients ---> Phenolic acid contents
●Quality - Yield
SLID-272 Seed Storage Reserves and Glucosinolates in Brassica rapa L. Grown on the International Space Station Investigated Organism: Brassica rapa (Brassica);
Organism Common Name: n.a.;
Organism Class: Food;
Studied Organ/Tissue/Part: Silique; Leaf;
Food Category: Vegetable; Oil crop;
Growth Stage During Space Flight: Seed to seed;
●n.a.
 ●n.a.
 ●Growth - Fruit and seed ---> Silique length
●Growth - Fruit and seed ---> Seeds per silique
●Component - Storage reserves ---> Starch
●Component - Storage reserves ---> Soluble carbohydrate
●Component - Storage reserves ---> Glucose equivalents
●Process - Phototropism ---> Chlorophyll content
●Component - Glucosinolate
●Quality - Yield
SLID-273 Transcriptome Analysis of Oryza sativa Calli Under Microgravity Investigated Organism: Oryza sativa;
Organism Common Name: Rice;
Organism Class: Food; Model organism;
Studied Organ/Tissue/Part: Calli;
Food Category: Grain;
Growth Stage During Space Flight: Tissue culture;
●n.a.
 ●n.a.
 ●Omics - Transcriptomics ---> Calli
●Environment - Simulated microgravity
SLID-274 Plant reproduction during spaceflight: importance of the gaseous environment Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Seed;
Food Category: n.a.;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Growth - Seed germination ---> Germination rate
●Process - Phototropism ---> Chloroplast morphology
●Process - Phototropism ---> Chloroplast DNA
●Process - Stress resistance ---> UV radiation
●Process - Stress resistance ---> DNA damage)
●Process - Stress resistance ---> Environment - Radiation
SLID-275 Seed-to-seed-to-seed growth and development of Arabidopsis in microgravity Investigated Organism: Arabidopsis thaliana;
Organism Common Name: thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Whole plant; Seed;
Food Category: ;
Growth Stage During Space Flight: Seed to seed to seed;
●n.a.
 ●n.a.
 ●Growth - Stem and branch ---> Branch angles
●Growth - Fruit and seed ---> Silique angles
●Component - Storage reserves ---> Seed protein bodies
●Component - Storage reserves ---> Seed protein contents
SLID-276 Survival and DNA Damage in Plant Seeds Exposed for 558 and 682 Days outside the International Space Station Investigated Organism: Nicotiana tabacum; Arabidopsis thaliana;
Organism Common Name: Tobacco; Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Seedling; Leaf; Flower;
Food Category: n.a.;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Growth - Seed germination ---> Germination rate
●Process - Phototropism ---> Chloroplast morphology
●Process - Phototropism ---> Chloroplast DNA
●Process - Stress resistance ---> UV radiation
●Process - Stress resistance ---> DNA damage)
●Process - Stress resistance ---> Environment - Radiation
SLID-277 A crinkly leaf and delay flowering mutant of tobacco obtained from recoverable satellite-flown seeds Investigated Organism: Nicotiana tabacum;
Organism Common Name: Tobacco;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Root; Root tip;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●Gravitational pull - Gravitropism
 ●n.a.
 ●Growth - Flower ---> Flowering
●Growth - Leaf ---> Crinkly leaf
●Omics - Genetics and breeding ---> Polymorphic sites
●Omics - Genetics and breeding ---> Mutation
SLID-278 Early Root Cap Development and Graviresponse in White Clover (Trifolium repens) Grown in Space and on a Two-Axis Clinostat Investigated Organism: Trifolium repens;
Organism Common Name: White clover;
Organism Class: Garden plant;
Studied Organ/Tissue/Part: Seedling;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Growth - Seed germination ---> Germination rate
●Growth - Root ---> Root length
●Growth - Root ---> Root angle
●Growth - Root ---> Cap cell stories
●Growth - Root ---> Columella cell height
●Growth - Root ---> Columella cell width
●Growth - Root ---> Gravitropism
●Component - Storage reserves ---> Protein bodies
●Component - Storage reserves ---> Starch
●Component - Storage reserves ---> Amyloplast frequency
●Component - Storage reserves ---> Amyloplast distal asymmetry
●Environment - Simulated microgravity
SLID-279 Microgravity induces changes in microsome-associated proteins of Arabidopsis seedlings grown on board the international space station Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Seedling;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Omics - Proteome ---> Microsome-associated protein
●Environment - Artificial gravity
SLID-280 Spaceflight induces specific alterations in the proteomes of Arabidopsis Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Root; Leaf;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Omics - Proteome ---> Leaf
●Omics - Proteome ---> Root
SLID-281 Microsome-associated proteome modifications of Arabidopsis seedlings grown on board the International Space Station reveal the possible effect on plants of space stresses other than microgravity Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Seedling; Root;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●Gravitational pull - Gravitropism
 ●n.a.
 ●Omics - Proteome ---> Microsome-associated protein
●Environment - Artificial gravity
SLID-282 A novel blue-light phototropic response is revealed in roots of Arabidopsis thaliana in microgravity Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Root tip;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Process - Phototropism ---> Blue light
●Process - Phototropism ---> Red light
●Growth - Root ---> Gravitropism
SLID-283 Genetic dissection of the Arabidopsis spaceflight transcriptome: Are some responses dispensable for the physiological adaptation of plants to spaceflight? Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Root;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●Gravitational pull - Gravitropism
 ●n.a.
 ●Omics - Transcriptomics ---> Root
●Omics - Transcriptomics of stress resistance ---> Spaceflight adaptation
●Omics - Genetics and breeding ---> Mutant
●Omics - Genetics and breeding ---> Genetic manipulation
SLID-284 The effect of spaceflight on the gravity-sensing auxin gradient of roots: GFP reporter gene microscopy on orbit Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Seedling;
Food Category: n.a.;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Growth - Root ---> Gravitropism
●Component - Plant hormone ---> Auxin
●Component - Plant hormone ---> Cytokinin
SLID-285 RNAseq Analysis of the Response of Arabidopsis thaliana to Fractional Gravity Under Blue-Light Stimulation During Spaceflight Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Leaf;
Food Category: n.a.;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Omics - Transcriptomics ---> Seedling
●Environment - Fractional gravity
SLID-286 Physiological, transcriptional, and metabolic alterations in spaceflight-subjected Senna obtusifolia Investigated Organism: Senna obtusifolia;
Organism Common Name: Sicklepod;
Organism Class: Herb;
Studied Organ/Tissue/Part: Seed;
Food Category: n.a.;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Component - Secondary metabolites
●Quality - Yield ---> Seed yield
●Omics - Transcriptomics of stress resistance ---> Antioxidant gene expression
SLID-287 Survival of plant seeds, their UV screens, and nptII DNA for 18 months outside the International Space Station Investigated Organism: Nicotiana tabacum; Arabidopsis thaliana;
Organism Common Name: Tobacco; Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Seed;
Food Category: n.a.;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Growth - Seed germination
●Process - DNA damage ---> DNA integrity
SLID-288 Caenorhabditis elegans survives atmospheric breakup of STS-107, space shuttle Columbia Investigated Organism: Caenorhabditis elegans;
Organism Common Name: Nematode;
Organism Class: Worm;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●n.a.
 ●Other profiles - Survive
SLID-289 Genomic response of the nematode Caenorhabditis elegans to spaceflight Investigated Organism: Caenorhabditis elegans;
Organism Common Name: Nematode;
Organism Class: Worm;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●n.a.
 ●Omics - Transcriptome ---> Whole animal
SLID-290 Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans Investigated Organism: Caenorhabditis elegans;
Organism Common Name: Nematode;
Organism Class: Worm;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●Aging
 ●Other profiles - Cell physiology ---> Polyglutamine aggregates
SLID-291 Reproductive and locomotory capacities of Caenorhabditis elegans were not affected by simulated variable gravities and spaceflight during the Shenzhou-8 mission Investigated Organism: Caenorhabditis elegans;
Organism Common Name: Nematode;
Organism Class: Worm;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●n.a.
 ●Development and Reproduction - Reproduction ---> Brood size
●Nervous and regulatory systems - Behavior ---> Locomotory behavior
●Environment - Hypergravity
●Environment - Simulated microgravity
SLID-292 The DNA damage response of C. elegans affected by gravity sensing and radiosensitivity during the Shenzhou-8 spaceflight Investigated Organism: Caenorhabditis elegans;
Organism Common Name: Nematode;
Organism Class: Worm;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●n.a.
 ●Omics - DNA damage ---> Gravity sensing
●Omics - DNA damage ---> Radiosensitivity
●Omics - Transcriptome
SLID-293 Microgravity elicits reproducible alterations in cytoskeletal and metabolic gene and protein expression in space-flown Caenorhabditis elegans Investigated Organism: Caenorhabditis elegans;
Organism Common Name: Nematode;
Organism Class: Worm;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●Muscle atrophy
 ●Omics - Transcriptome ---> Whole animal
●Omics - Metabolome ---> Whole animal
●Nervous and regulatory systems - Behavior ---> Altered movement
SLID-294 Comparative Studies of the Thick-Toed Geckos after the 16 and 12 Days Spaceflight in Foton-M Experiments Investigated Organism: Chondrodactylus turneri;
Organism Common Name: Thick-toed gecko;
Organism Class: Reptile;
Studied Organ/Tissue/Part: Whole animal; Brain; Heart; Liver; Pancreas; Spleen; Small intestine;
●n.a.
 ●n.a.
 ●Other profiles - Organ morphology ---> Brain
●Other profiles - Organ morphology ---> Heart
●Other profiles - Organ morphology ---> Liver
●Other profiles - Organ morphology ---> Pancreas
●Other profiles - Organ morphology ---> Spleen
●Other profiles - Organ morphology ---> Small intestine
●Nervous and regulatory systems - Behavior ---> Video record
SLID-295 Recovery from 6-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Muscle; Blood;
●n.a.
 ●Stress
●Immune system dysregulation
 ●Nervous and regulatory systems - Stress analysis ---> Stress response
●Cardiovascular and Immune System - Immune function ---> Inflammatory
●Musculoskeletal system - Muscle properties ---> Muscle protein
SLID-296 Effects of spaceflight on the composition and function of the human gut microbiota Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Microbiota;
●n.a.
 ●Pathogen virulence
●Gastrointestinal homeostasis
●Pathogen antibiotic resistance
 ●Omics - Microbiome ---> Gut
SLID-297 The influence of spaceflight on the astronaut salivary microbiome and the search for a microbiome biomarker for viral reactivation Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Saliva; Microbiota;
●n.a.
 ●Latent viral reactivation
 ●Omics - Microbiome
●Cardiovascular and Immune System - Immune function ---> Latent viral reactivation
SLID-298 The effects of spaceflight on open-loop and closed-loop postural control mechanisms: human neurovestibular studies on SLS-2 Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Behavior;
●n.a.
 ●Neurovestibular decline
●Sensorimotor decline
 ●Nervous and regulatory systems - Neuromotor control ---> Postural control
●Nervous and regulatory systems - Neuro-sensory function ---> Proprioception
SLID-299 Filamentous fungi exposed to spaceflight stresses including known levels of ultraviolet irradiations Investigated Organism: Trichophyton terrestre; Chaetomium globosum;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Fungus;
Microbe Type: Environmental microorganism;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Morphology - Mycelium ---> Hyphal growth dynamics
●Environment - Radiation
SLID-300 The effects of space flight on the production of monorden by Humicola fuscoatra WC5157 in solid-state fermentation Investigated Organism: Humicola fuscoatra;
Studied Organism Strains: WC5157;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Fungus;
Microbe Type: Industrial microorganism; Plant pathogen;
Microbe Form: Active organism;
●n.a.
 ●Antifungal resistance
 ●Metabolite production - Potential drug ---> Monorden
●Metabolite production - pharmaceutical metabolite ---> Antibiotic drug production
SLID-301 Chromosome mechanics of fungi under spaceflight conditions--tetrad analysis of two-factor crosses between spore color mutants of Sordaria macrospora Investigated Organism: Sordaria macrospora;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Fungus;
Microbe Type: Model organism;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Omics - Genome ---> Chromosome mechanics
●Omics - Genome ---> Gene recombination
●Omics - Genome ---> DNA strand break
●Morphology - Spore color
SLID-302 Analysis of deletion mutations of the rpsL gene in the yeast Saccharomyces cerevisiae detected after long-term flight on the Russian space station Mir Investigated Organism: Saccharomyces cerevisiae;
Organism Common Name: Baker's yeast;
Organism Class:
Organism Category: Fungus;
Microbe Type: Model organism; Industrial microorganism;
Microbe Form: Spores;
●n.a.
 ●n.a.
 ●Omics - Genome ---> Mutation spectrum
SLID-303 The effect of space flight on the production of actinomycin D by Streptomyces plicatus Investigated Organism: Streptomyces plicatus;
Studied Organism Strains: WC56452;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Industrial microorganism;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Cell behavior - Survival and growth ---> Colony-forming
●Cell behavior - Survival and growth ---> Sporulation
●Metabolite production - pharmaceutical metabolite ---> Antibiotic drug production
●Metabolite production - Drug ---> Actinomycin D
SLID-304 Effects of space flight, clinorotation, and centrifugation on the substrate utilization efficiency of E. coli Investigated Organism: Escherichia coli;
Studied Organism Strains: ATCC 4157;
Organism Common Name: E. coli;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Normal flora of Human; Model organism; Human opportunistic pathogen;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Cell behavior - Survival and growth ---> Growth rate
●Cell behavior - Survival and growth ---> Substrate utilization efficiency
●Environment - Simulated microgravity
●Environment - Hypergravity
SLID-305 Microbial antibiotic production aboard the International Space Station Investigated Organism: Streptomyces plicatus;
Studied Organism Strains: WC56452;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Industrial microorganism;
Microbe Form: Spores; Active organism;
●n.a.
 ●n.a.
 ●Cell behavior - Survival and growth ---> Cell viability
●Morphology - Cell volume
●Metabolite production - pharmaceutical metabolite ---> Antibiotic drug production
●Metabolite production - Drug ---> Actinomycin D
SLID-306 Preliminary report on the biological effects of space flight on the producing strain of a new immunosuppressant, Kanglemycin C Investigated Organism: Nocardia mediterranei var. kanglensis 1747-64;
Studied Organism Strains: kanglensis 1747-64;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Environmental microorganism;
Microbe Form: Spores;
●n.a.
 ●n.a.
 ●Morphology - Mycelium ---> Mycelium shape
●Morphology - Broth color
●Metabolite production - Drug ---> Kanglemycin C
●Metabolite production - pharmaceutical metabolite ---> Immunosuppressant drug production
SLID-307 Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq Investigated Organism: Salmonella typhimurium;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human pathogen;
Microbe Form: Active organism;
●Polymer network-Biofilm ---> Biofilm formation
●Polymer network-Biofilm ---> Proteomic
 ●Virulence
 ●Omics - Transcriptome
●Omics - Proteome
●Morphology - Biofilm
SLID-308 Mold species in dust from the International Space Station identified and quantified by mold-specific quantitative PCR Investigated Organism: Molds;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Fungus;
Microbe Type: Environmental microorganism;
Microbe Form: Spacecraft sample;
●n.a.
 ●n.a.
 ●Omics - Microbiome
●Other profiles - Microbial colonization on space crafts
●Omics - Spacecraft microbiome monitoring
SLID-309 Effects of spaceflight on polysaccharides of Saccharomyces cerevisiae cell wall Investigated Organism: Saccharomyces cerevisiae;
Studied Organism Strains: FL01,FL03,2.0016,2.1424;
Organism Common Name: Baker's yeast;
Organism Class:
Organism Category: Fungus;
Microbe Type: Industrial microorganism; Model organism;
Microbe Form: Freeze-dried organism;
●n.a.
 ●n.a.
 ●Morphology - Cell wall ---> Cell wall thickness
●Morphology - Cell wall ---> Cell wall component
SLID-310 Media ion composition controls regulatory and virulence response of Salmonella in spaceflight Investigated Organism: Salmonella typhimurium;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human pathogen;
Microbe Form: Active organism;
●n.a.
 ●Virulence
 ●Environment - Medium nutritional condition ---> Ion composition
●Omics - Transcriptome
●Omics - Proteome
●Other profiles - Molecular pathway
SLID-311 Isolation of rpoB mutations causing rifampicin resistance in Bacillus subtilis spores exposed to simulated Martian surface conditions Investigated Organism: Bacillus subtilis;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Model organism; Plant probiotic;
Microbe Form: Spores;
●n.a.
 ●Antibiotic resistance
 ●Environment - Simulated martian conditions
●Omics - Genome ---> Mutation
●Cell behavior - Survival and growth
SLID-312 Response of Pseudomonas aeruginosa PAO1 to low shear modelled microgravity involves AlgU regulation Investigated Organism: Pseudomonas aeruginosa;
Studied Organism Strains: PAO1;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human opportunistic pathogen;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Environment - Simulated microgravity
●Omics - Transcriptome
●Stress resistance - Oxidative stress resistance
●Stress resistance - Heat shock resistance
●Metabolite production - Biomaterial ---> Alginate
SLID-313 Transcriptional and proteomic responses of Pseudomonas aeruginosa PAO1 to spaceflight conditions involve Hfq regulation and reveal a role for oxygen Investigated Organism: Pseudomonas aeruginosa;
Studied Organism Strains: PAO1;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human opportunistic pathogen;
Microbe Form: Active organism;
●n.a.
 ●Virulence
 ●Omics - Transcriptome
●Omics - Proteome
SLID-314 Enhanced S-adenosyl-l-methionine production in Saccharomyces cerevisiae by spaceflight culture, overexpressing methionine adenosyltransferase and optimizing cultivation Investigated Organism: Saccharomyces cerevisiae;
Studied Organism Strains: H5M147,H5MR83;
Organism Common Name: Baker's yeast;
Organism Class:
Organism Category: Fungus;
Microbe Type: Model organism; Industrial microorganism;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Cell behavior - Survival and growth ---> Growth rate
●Metabolite production - Drug ---> S-adenosyl-l-methionine
SLID-315 Mutagenesis in bacterial spores exposed to space and simulated martian conditions: data from the EXPOSE-E spaceflight experiment PROTECT Investigated Organism: Bacillus subtilis;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Plant probiotic; Model organism;
Microbe Form: Spores;
●n.a.
 ●n.a.
 ●Environment - Simulated martian conditions
●Omics - Genome ---> Mutation spectrum
SLID-316 Transcriptomic responses of germinating Bacillus subtilis spores exposed to 1.5 years of space and simulated martian conditions on the EXPOSE-E experiment PROTECT Investigated Organism: Bacillus subtilis;
Studied Organism Strains: 168 (trpC2);
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Model organism; Plant probiotic;
Microbe Form: Spores; Active organism;
●n.a.
 ●n.a.
 ●Environment - Simulated martian conditions
●Omics - Transcriptome
SLID-317 Spaceflight-induced enhancement of 2-keto-L-gulonic acid production by a mixed culture of Ketogulonigenium vulgare and Bacillus thuringiensis Investigated Organism: Bacillus thuringiensis; Ketogulonigenium vulgare;
Studied Organism Strains: KB2194‐320; B1514; K2 and B1514;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Industrial microorganism;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Metabolite production - Drug precursor ---> 2‐keto‐L‐gulonic acid
●Metabolite production - pharmaceutical metabolite ---> Vitamin precurtor production
SLID-318 Spaceflight promotes biofilm formation by Pseudomonas aeruginosa Investigated Organism: Pseudomonas aeruginosa;
Studied Organism Strains: PA14;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human opportunistic pathogen;
Microbe Form: Active organism;
●Polymer network-Biofilm ---> Biofilm formation
 ●n.a.
 ●Cell behavior - Survival and growth ---> Viable cell number
●Morphology - Biofilm
●Cell behavior - Motility
SLID-319 Effect of spaceflight on Pseudomonas aeruginosa final cell density is modulated by nutrient and oxygen availability Investigated Organism: Pseudomonas aeruginosa;
Studied Organism Strains: PA14;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human opportunistic pathogen;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Environment - Medium nutritional condition ---> Phosphate concentration
●Environment - Medium nutritional condition ---> Carbon source
●Environment - Medium nutritional condition ---> Oxygen availability
●Cell behavior - Survival and growth ---> Cell density
●Cell behavior - Motility
SLID-320 Effects of microgravity on the virulence of Listeria monocytogenes, Enterococcus faecalis, Candida albicans, and methicillin-resistant Staphylococcus aureus Investigated Organism: Staphylococcus aureus; Listeria monocytogenes; Enterococcus faecalis; Candida albicans;
Studied Organism Strains: ATCC 7644; FPR3757, ATCC BAA-1556; OG1RF, ATCC 47077; SC5314;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human opportunistic pathogen; Normal flora of Human; Human pathogen;
Microbe Form: Active organism;
●n.a.
 ●Virulence
 ●n.a.
SLID-321 A multi-omic analysis of an Enterococcus faecium mutant reveals specific genetic mutations and dramatic changes in mRNA and protein expression Investigated Organism: Enterococcus faecium;
Studied Organism Strains: CGMCC 1.2136;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human opportunistic pathogen; Normal flora of Human;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Omics - Genome
●Omics - Transcriptome
●Omics - Proteome
SLID-322 Protein patterns of black fungi under simulated Mars-like conditions Investigated Organism: Exophiala jeanselmei; Knufia perforans; Cryomyces antarcticus;
Studied Organism Strains: MA 2853; MA 5682; MA 1299;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Fungus;
Microbe Type: Human opportunistic pathogen; Extremophile;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Cell behavior - Survival and growth
●Omics - Proteome
●Environment - Simulated martian conditions
SLID-323 Comparative genomic analysis of Klebsiella pneumonia (LCT-KP214) and a mutant strain (LCT-KP289) obtained after spaceflight Investigated Organism: Klebsiella pneumonia;
Studied Organism Strains: LCT-KP289,LCT-KP214;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human pathogen;
Microbe Form: Active organism;
●Polymer network-Biofilm ---> Biofilm architecture
 ●Antibiotic resistance
 ●Omics - Genome ---> Genomic structural variations
SLID-324 Genomic and transcriptomic analysis of NDM-1 Klebsiella pneumoniae in spaceflight reveal mechanisms underlying environmental adaptability Investigated Organism: Klebsiella pneumoniae;
Studied Organism Strains: ATCC BAA-2146;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human pathogen;
Microbe Form: Active organism;
●Polymer network-Biofilm ---> Biofilm formation
 ●Antibiotic resistance
 ●Omics - Genome
●Stress resistance - Oxidative stress resistance
●Morphology - Biofilm
SLID-325 Use of genome sequencing to assess nucleotide structure variation of Staphylococcus aureus strains cultured in spaceflight on Shenzhou-X, under simulated microgravity and on the ground Investigated Organism: Staphylococcus aureus;
Studied Organism Strains: LCT-SAS, LCT-SAM, LCT-SAG;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Model organism; Human opportunistic pathogen; Normal flora of Human;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Omics - Genome ---> Omics - Genome structure variation
●Environment - Simulated microgravity
SLID-326 Effects of simulated microgravity and spaceflight on morphological differentiation and secondary metabolism of Streptomyces coelicolor A3(2) Investigated Organism: Treptomyces coelicolor;
Studied Organism Strains: A3(2),M145;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Industrial microorganism;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Cell behavior - Survival and growth ---> Life cycle shorten
●Cell behavior - Survival and growth ---> Sporulation
●Omics - Transcriptome
SLID-327 Genomic and Proteomic Analysis of Escherichia coli After Spaceflight Reveals Changes Involving Metabolic Pathways Investigated Organism: Escherichia coli;
Studied Organism Strains: LCT-EC67;
Organism Common Name: E. coli;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Model organism; Normal flora of Human; Human opportunistic pathogen;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Omics - Proteome
SLID-328 Effects of Space Environment on Genome, Transcriptome, and Proteome of Klebsiella pneumoniae Investigated Organism: Klebsiella pneumoniae;
Studied Organism Strains: LCT-KP289,LCT-KP214;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human pathogen;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Omics - Genome ---> SNP
●Omics - Genome ---> Plasmid copy number variation
●Omics - Transcriptome
●Omics - Proteome
SLID-329 Survival of Antarctic Cryptoendolithic Fungi in Simulated Martian Conditions On Board the International Space Station Investigated Organism: Cryomyces minteri; Cryomyces antarcticus;
Studied Organism Strains: CCFEE 5187; CCFEE 515;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Fungus;
Microbe Type: Extremophile;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Cell behavior - Survival and growth ---> Colony-forming ability
●Cell behavior - Survival and growth ---> Cell viability
●Environment - Simulated martian conditions
SLID-330 Characterization of fungi isolated from the equipment used in the International Space Station or Space Shuttle Investigated Organism: Fungi;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Fungus;
Microbe Type: Environmental microorganism;
Microbe Form: Spacecraft sample;
●n.a.
 ●Antibiotic resistance
 ●Omics - Microbiome
●Other profiles - Microbial colonization on space crafts
●Omics - Spacecraft microbiome monitoring
SLID-331 Fungal Spores Viability on the International Space Station Investigated Organism: Aspergillus niger; Cladosporium herbarum; Basipetospora halophila; Ulocladium chartarum;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Fungus;
Microbe Type: Human opportunistic pathogen; Industrial microorganism; Environmental microorganism; Human pathogen;
Microbe Form: Spores; Active organism;
●n.a.
 ●n.a.
 ●Cell behavior - Survival and growth ---> Spore spreading
●Cell behavior - Survival and growth ---> Spore viability
SLID-332 Cultivation of Staphylococcus epidermidis in the Human Spaceflight Environment Leads to Alterations in the Frequency and Spectrum of Spontaneous Rifampicin-Resistance Mutations in the rpoB Gene Investigated Organism: Staphylococcus epidermidis;
Studied Organism Strains: ATCC 12228;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Normal flora of Human; Human opportunistic pathogen;
Microbe Form: Active organism;
●Polymer network - Biofilm ---> Biofilm formation
 ●Antibiotic resistance
 ●Morphology - Biofilm
●Omics - Genome ---> Mutation spectrum
SLID-333 A Systems Biology Analysis Unfolds the Molecular Pathways and Networks of Two Proteobacteria in Spaceflight and Simulated Microgravity Conditions Investigated Organism: Pseudomonas aeruginosa; Salmonella typhimurium;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human pathogen; Human opportunistic pathogen;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Environment - Simulated microgravity
●Other profiles - Molecular pathway
●Omics - Transcriptome
SLID-334 A Molecular Genetic Basis Explaining Altered Bacterial Behavior in Space Investigated Organism: Escherichia coli;
Studied Organism Strains: ATCC 4157;
Organism Common Name: E. coli;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Model organism; Normal flora of Human; Human opportunistic pathogen;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Omics - Transcriptome
SLID-335 Characterization of Aspergillus fumigatus Isolates from Air and Surfaces of the International Space Station Investigated Organism: Aspergillus fumigatus;
Studied Organism Strains: ISSFT-021,IF1SW-F5;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Fungus;
Microbe Type: Human opportunistic pathogen;
Microbe Form: Active organism;
●n.a.
 ●Antibiotic resistance
 ●Omics - Genome
●Cell behavior - Survival and growth ---> Growth rate
●Metabolite production - Potential drug ---> Fumigaclavine A
●Metabolite production - Potential drug ---> Fumigaclavine C
●Metabolite production - Potential drug ---> FumiquinazolineC/D
●Metabolite production - Potential drug ---> Pyripyropene A
●Metabolite production - Potential drug ---> Fumagillin
●Metabolite production - Potential drug ---> Helvolic acid
●Other profiles - Microbial colonization on space crafts
SLID-336 The Impact of Space Flight on Survival and Interaction of Cupriavidus metallidurans CH34 with Basalt, a Volcanic Moon Analog Rock Investigated Organism: Cupriavidus metallidurans;
Studied Organism Strains: CH34;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Plant probiotic;
Microbe Form: Active organism;
●Polymer network-Biofilm ---> Biofilm formation
 ●n.a.
 ●Morphology - Biofilm
SLID-337 Non-Toxin-Producing Bacillus cereus Strains Belonging to the B. anthracis Clade Isolated from the International Space Station Investigated Organism: Bacillus anthracis-B. cereus-B. thuringiensis group;
Studied Organism Strains: 11 strains;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human pathogen;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Omics - Genome
●Other profiles - Species identification
●Other profiles - Microbial colonization on space crafts
SLID-338 Whole metagenome profiles of particulates collected from the International Space Station Investigated Organism: Microbiota;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria/Fungus;
Microbe Type: Microbiota;
Microbe Form: Spacecraft sample;
●n.a.
 ●n.a.
 ●Omics - Microbiome ---> Metagenome
●Omics - Microbiome ---> Microbial diversity
●Other profiles - Microbial colonization on space crafts
●Omics - Spacecraft microbiome monitoring
SLID-339 Exposure of Mycobacterium marinum to low-shear modeled microgravity: effect on growth, the transcriptome and survival under stress Investigated Organism: Mycobacterium marinum;
Studied Organism Strains: 1218R;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human pathogen;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Cell behavior - Survival and growth ---> Growth rate
●Morphology - Bacterium size
●Omics - Transcriptome
SLID-340 Draft Genome Sequences from a Novel Clade of Bacillus cereus Sensu Lato Strains, Isolated from the International Space Station Investigated Organism: Bacillus cereus (Sensu Lato);
Studied Organism Strains: ISSFR-3F, ISSFR-9F, ISSFT-23F,JEM-2,S1-R4H1-FB,S2-R3J1-FB-BA1;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human opportunistic pathogen; Human probiotic;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Omics - Genome
●Other profiles - Microbial colonization on space crafts
SLID-341 Cultivation in Space Flight Produces Minimal Alterations in the Susceptibility of Bacillus subtilis Cells to 72 Different Antibiotics and Growth-Inhibiting Compounds Investigated Organism: Bacillus subtilis;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Plant probiotic; Model organism;
Microbe Form: Active organism;
●n.a.
 ●Antibiotic resistance
 ●Cell behavior - Survival and growth
SLID-342 Phenotypic Changes Exhibited by E. coli Cultured in Space Investigated Organism: Escherichia coli;
Studied Organism Strains: ATCC 4157;
Organism Common Name: E. coli;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Model organism; Human opportunistic pathogen; Normal flora of Human;
Microbe Form: Active organism;
●n.a.
 ●Antibiotic resistance
 ●Morphology - Cell ---> Cell size
●Morphology - Cell ---> Cell envelope thickness
●Morphology - Cell ---> Cell ultrastructure
●Cell behavior - Cluster
SLID-343 Payload hardware and experimental protocol development to enable future testing of the effect of space microgravity on the resistance to gentamicin of uropathogenic Escherichia coli and its σs-deficient mutant Investigated Organism: Escherichia coli;
Studied Organism Strains: AMG1;
Organism Common Name: E. coli;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human opportunistic pathogen; Model organism; Normal flora of Human;
Microbe Form: Active organism;
●n.a.
 ●Antibiotic resistance
 ●Environment - Simulated microgravity
●Cell behavior - Survival and growth ---> Growth rate
SLID-344 Detection of antimicrobial resistance genes associated with the International Space Station environmental surfaces Investigated Organism: Acinetobacter pittii; Klebsiella quasipneumoniae subsp. similipneumoniae; Pantoea conspicua; Staphylococcus aureus subsp. anaerobius; Pantoea dispersa; Staphylococcus hominis; Staphylococcus haemolyticus; Enterobacter bugandensis;
Studied Organism Strains: IIF3SW-P1,IIF3SW-P2; IIF1SW-B2,IIF1SW-P1,IIF1SW-P2,IIF1SW-P3,IIF1SW-P4,IIF1SW-P5; IIIF1SW-B1,IIIF1SW-B3,IIIF1SW-B4,IIIF1SW-B5,IIIF4SW-B1; IF1SW-B2,IF2SW-B2,IF2SW-B3,IF1SW-P3,IF1SW-P4,IF2SW-P1,IF3SW-P1; IF4SW-P1,IF4SW-P3,IF4SW-P5,IF6SW-P1A,IF6SW-P2,IF6SW-P3A,IF7SW-P3,IIF6SW-P1,IIF6SW-P2,IIF6SW-P3,IIF8SW-P1,IIF8SW-P2; IF5SW-B1,IF5SW-B2,IF5SW-P1,IF5SW-P2,IIF5SW-B1,IIF5SW-B2,IIF5SW-B5,IIF5SW-P1,IIF5SW-P2,IIF5SW-P3,IIF5SW-P4,IIF5SW-P5; IIF2SW-P3,IIF2SW-P4,IIF2SW-P5; IF2SW-B1,IF2SW-B4,IF2SW-B5,IF2SW-P2,IF2SW-P3,IF3SW-P2;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human opportunistic pathogen; Normal flora of Human; Human pathogen; Model organism;
Microbe Form: Active organism;
●n.a.
 ●Antibiotic resistance
 ●Omics - Genome
●Other profiles - Microbial colonization on space crafts
SLID-345 Alterations in the Spectrum of Spontaneous Rifampicin-Resistance Mutations in the Bacillus subtilis rpoB Gene after Cultivation in the Human Spaceflight Environment Investigated Organism: Bacillus subtilis;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Model organism; Plant probiotic;
Microbe Form: Active organism;
●n.a.
 ●Antibiotic resistance
 ●Omics - Genome ---> Mutation spectrum
●Omics - Genome ---> Mutagenic potential
SLID-346 Probiotics into outer space: feasibility assessments of encapsulated freeze-dried probiotics during 1 month's storage on the International Space Station Investigated Organism: Lactobacillus casei;
Studied Organism Strains: Shirota;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human probiotic;
Microbe Form: Freeze-dried organism;
●n.a.
 ●Probiotic properties
 ●Cell behavior - Survival and growth
●Omics - Genome ---> Polymorphic DNA profile
●Omics - Genome ---> Variant frequency
SLID-347 Characterization of Aspergillus niger Isolated from the International Space Station Investigated Organism: Aspergillus niger;
Studied Organism Strains: JSC-093350089,ATCC 1015;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Fungus;
Microbe Type: Industrial microorganism; Human opportunistic pathogen;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Cell behavior - Survival and growth ---> Growth rate
●Morphology - Colony ---> Pigment distribution
●Omics - Proteome
●Other profiles - Microbial colonization on space crafts
SLID-348 Meta-analysis of data from spaceflight transcriptome experiments does not support the idea of a common bacterial "spaceflight response" Investigated Organism: Pseudomonas aeruginosa; Salmonella enterica; Staphylococcus aureus; Bacillus subtilis; Rhodospira rubrum;
Studied Organism Strains: S1H; UAMS-1; PAO1; 168; χ3339;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Normal flora of Human; Human opportunistic pathogen; Model organism; Environmental microorganism; Plant probiotic; Human pathogen;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Omics - Transcriptome
SLID-349 Decreased biofilm formation ability of Acinetobacter baumannii after spaceflight on China's Shenzhou 11 spacecraft Investigated Organism: Acinetobacter baumannii;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human opportunistic pathogen;
Microbe Form: Active organism;
●Polymer network-Biofilm ---> Biofilm formation
●Polymer network-Biofilm ---> Proteomic
 ●Antibiotic resistance
 ●Morphology - Biofilm
●Cell behavior - Survival and growth ---> Growth rate
●Omics - Genome ---> Mutation
●Omics - Transcriptome
SLID-350 International Space Station conditions alter genomics, proteomics, and metabolomics in Aspergillus nidulans Investigated Organism: Aspergillus nidulans;
Studied Organism Strains: LO1362,CW12001;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Fungus;
Microbe Type: Model organism;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Omics - Genome
●Omics - Proteome
●Metabolite production - Metabolomics
SLID-351 Proteomic characterization of Aspergillus fumigatus isolated from air and surfaces of the International Space Station Investigated Organism: Aspergillus fumigatus;
Studied Organism Strains: ISSFT-021,IF1SW-F4;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Fungus;
Microbe Type: Human opportunistic pathogen;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Omics - Proteome
●Other profiles - Microbial colonization on space crafts
SLID-352 LCT-EF258 with S17I Mutation in DprA Exhibits Horizontal Gene Transfer Deficiency After Spaceflight Investigated Organism: Enterococcus faecium;
Studied Organism Strains: LCT-EF258,LCT-EF90;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Normal flora of Human; Human opportunistic pathogen;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Omics - Genome ---> Horizontal gene transfer
SLID-353 Microbial community composition of water samples stored inside the International Space Station Investigated Organism: Microbiota;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Environmental microorganism;
Microbe Form: Spacecraft sample;
●n.a.
 ●n.a.
 ●Omics - Microbiome
●Cell behavior - Survival and growth ---> Viable bacterial load
●Cell behavior - Survival and growth ---> Total bacterial load
●Other profiles - Microbial colonization on space crafts
●Omics - Spacecraft microbiome monitoring
SLID-354 Reactivation of Microbial Strains and Synthetic Communities After a Spaceflight to the International Space Station: Corroborating the Feasibility of Essential Conversions in the MELiSSA Loop Investigated Organism: Nitrosomonas ureae; Nitrobacter winogradskyi; Rhodospirillum rubrum; Arthrospira sp.; Cupriavidus pinatubonensis; Nitrosomonas europaea;
Studied Organism Strains: Nb255; S1H; ATCC19718; PCC 8005; 1245; Nm10;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Potential food; Environmental microorganism;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Cell behavior - Survival and growth ---> Cell viability
●Environment - Radiation
SLID-355 Physical Forces Modulate Oxidative Status and Stress Defense Meditated Metabolic Adaptation of Yeast Colonies: Spaceflight and Microgravity Simulations Investigated Organism: Saccharomyces cerevisiae;
Studied Organism Strains: BY4743;
Organism Common Name: Baker's yeast;
Organism Class:
Organism Category: Fungus;
Microbe Type: Industrial microorganism; Model organism;
Microbe Form: Active organism;
●Shear forces - Shear stress - Cell adhesion under shear stress
 ●n.a.
 ●Stress resistance - Oxidative stress resistance
●Cell behavior - Survival and growth ---> Apoptosis
●Environment - Shear stress
●Environment - Simulated microgravity
SLID-356 Decreased metabolism and increased tolerance to extreme environments in Staphylococcus warneri during long-term spaceflight Investigated Organism: Staphylococcus warneri;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human opportunistic pathogen; Normal flora of Human;
Microbe Form: Active organism;
●Polymer network-Biofilm ---> Biofilm formation
●Polymer network-Biofilm ---> Transcriptomic
 ●Antibiotic resistance
 ●Omics - Genome
●Omics - Transcriptome
●Omics - Proteome
●Morphology - Biofilm
SLID-357 EcAMSat spaceflight measurements of the role of σs in antibiotic resistance of stationary phase Escherichia coli in microgravity Investigated Organism: Escherichia coli;
Organism Common Name: E. coli;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Normal flora of Human; Human opportunistic pathogen; Model organism;
Microbe Form: Active organism;
●n.a.
 ●Antibiotic resistance
 ●Cell behavior - Survival and growth ---> Growth rate
SLID-358 Spaceflight and simulated microgravity conditions increase virulence of Serratia marcescens in the Drosophila melanogaster infection model Investigated Organism: Serratia marcescens;
Studied Organism Strains: Db11;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human opportunistic pathogen;
Microbe Form: Active organism;
●n.a.
 ●Virulence
 ●Environment - Simulated microgravity
●Omics - Transcriptome ---> Host
SLID-359 Metabolomic Analysis of Aspergillus niger Isolated From the International Space Station Reveals Enhanced Production Levels of the Antioxidant Pyranonigrin A Investigated Organism: Aspergillus niger;
Studied Organism Strains: JSC-093350089,ATCC 1015;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Fungus;
Microbe Type: Human opportunistic pathogen; Industrial microorganism;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Metabolite production - pharmaceutical metabolite ---> Antioxidant molecule production
●Metabolite production - Antioxidant ---> Pyranonigrin A
SLID-360 Comparisons of Transcriptome Profiles from Bacillus subtilis Cells Grown in Space versus High Aspect Ratio Vessel (HARV) Clinostats Reveal a Low Degree of Concordance Investigated Organism: Bacillus subtilis;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Plant probiotic; Model organism;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Omics - Transcriptome
●Environment - Simulated microgravity
SLID-361 The postmitotic Saccharomyces cerevisiae after spaceflight showed higher viability Investigated Organism: Saccharomyces cerevisiae;
Studied Organism Strains: ATCC 18824;
Organism Common Name: Baker's yeast;
Organism Class:
Organism Category: Fungus;
Microbe Type: Industrial microorganism; Model organism;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Cell behavior - Survival and growth ---> Viability
●Cell behavior - Survival and growth ---> Cell cycle
SLID-362 Transcriptomic and proteomic responses of Serratia marcescens to spaceflight conditions involve large-scale changes in metabolic pathways Investigated Organism: Serratia marcescens;
Studied Organism Strains: LCT-SM213, LCTSM262, LCT-SM166;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human opportunistic pathogen;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Omics - Transcriptome
●Omics - Proteome
SLID-363 The risk of Staphylococcus skin infection during space travel and mitigation strategies Investigated Organism: Staphylococcus aureus;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Normal flora of Human; Human opportunistic pathogen; Model organism;
Microbe Form: Active organism;
●n.a.
 ●Microbial infection risk assessment
 ●Other profiles - Microbial colonization on space crafts
SLID-364 Space-flight Mutation of Streptomyces gilvosporeus for Enhancing Natamycin Production Investigated Organism: Streptomyces gilvosporeus;
Studied Organism Strains: LK-22;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Industrial microorganism;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Cell behavior - Survival and growth
●Omics - Genome ---> Mutation
●Metabolite production - Drug ---> Natamycin
●Metabolite production - pharmaceutical metabolite ---> Antibiotic drug production
SLID-365 Effects of Microgravity on the Virulence of Salmonella Toward Caenorhabditis elegans Investigated Organism: Salmonella;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human pathogen;
Microbe Form: Active organism;
●n.a.
 ●Virulence
 ●Environment - Simulated microgravity
●Omics - Genome ---> Mutagenesis
SLID-366 Analysis of genetic variation in Ganoderma Lucidum after space flight Investigated Organism: Ganoderma lucidum;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Fungus;
Microbe Type: Medicinal microorganism;
Microbe Form: Active organism;
●n.a.
 ●n.a.
 ●Omics - Genome ---> Amplified fragment length polymorphism
SLID-367 Modification of reproductive development in Arabidopsis thaliana under spaceflight conditions Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Flower; Silique;
Food Category: n.a.;
Growth Stage During Space Flight: Seed to mature plant;
●n.a.
 ●n.a.
 ●Growth - Flower ---> Flower number
●Growth - Flower ---> Pollen viability
●Growth - Fruit and seed ---> Silique fertility
SLID-368 Changes in plant medium composition after a spaceflight experiment: Potassium levels are of special interest Investigated Organism: Xanthisma gracile; Hemerocallis cv Autumn Blaze;
Organism Common Name: n.a.; Day lily;
Organism Class: Garden plant; Food;
Studied Organ/Tissue/Part: Medium composition;
Food Category: n.a.; Vegetable;
Growth Stage During Space Flight: Mature plant;
●n.a.
 ●n.a.
 ●Environment - Medium composition change
SLID-369 Effect on a Flour Beetle of Irradiation during Space Flight Investigated Organism: Tribolium confusum;
Organism Common Name: Flour Beetle;
Organism Class: Arthropod;
Studied Organ/Tissue/Part: Pupae; Larvae;
●n.a.
 ●n.a.
 ●Development and Reproduction - Development ---> Molting failure
●Development and Reproduction - Development ---> Pupal death
●Development and Reproduction - Development ---> Pupal period prolongation
●Environment - Radiation
SLID-370 Pharmacokinetics of acetaminophen administered in tablets and capsules under long-term space flight conditions Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-371 Evaluation of physical and chemical changes in pharmaceuticals flown on space missions Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-372 Stability of vitamin B complex in multivitamin and multimineral supplement tablets after space flight Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-373 Medication use by U.S. crewmembers on the International Space Station Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-374 Chemical Potency and Degradation Products of Medications Stored Over 550 Earth Days at the International Space Station Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-375 Principles of Clinical Medicine for Space Flight Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-376 Prevalence of sleep deficiency and use of hypnotic drugs in astronauts before, during, and after spaceflight: an observational study Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-377 Spaceflight medical countermeasures: a strategic approach for mitigating effects from solar particle events Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-378 Physiological, pharmacokinetic, and pharmacodynamic changes in space Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-379 Bioavailability of Promethazine during Spaceflight Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-380 Spaceflight Medical Systems Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-381 Aquatic invertebrate protein sources for long-duration space travel Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-382 Assessment of nutrient stability in foods from the space food system after long-duration spaceflight on the ISS Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-383 Development of Spaceflight Foods with High Microbial Concentrations Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-384 Factors affecting flavor perception in space: Does the spacecraft environment influence food intake by astronauts? Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-385 Initial assessment of the nutritional quality of the space food system over three years of ambient storage Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-386 Kinetic parameters of thiamine degradation in NASA spaceflight foods determined by the endpoints method for long-term storage Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-387 Mission to Mars: food production and processing for the final frontier Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-388 Space food and bacterial infections: Realities of the risk and role of science Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-389 Spaceflight Metabolism and Nutritional Support Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-390 The Spaceflight Food System: A Case Study in Long Duration Preservation Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-391 Spaceflight Metabolism and Nutritional Support Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-392 Inflight Salivary Pharmacokinetics of Scopolamine and Dextroamphetamine Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-393 In-flight Pharmacokinetics of Acetaminophen in Saliva Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-394 A Psychiatric Formulary for Deep Space Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-395 Apollo food technology apollo food technology Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-396 Risk of Performance Decrement and Crew Illness Due to an Inadequate Food System Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-397 Effect of spaceflight on cardiovascular responses to upright posture in a 77-year-old astronaut Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Vessel; Heart;
●Fluid dynamics - Hemodynamics
 ●n.a.
 ●Cardiovascular and Immune System - Heart rhythm ---> Heart rate
●Cardiovascular and Immune System - Heart rhythm ---> Stroke volume
●Cardiovascular and Immune System - Heart rhythm ---> Cardiac output
●Cardiovascular and Immune System - Vessel properties ---> Systolic pressure
●Cardiovascular and Immune System - Vessel properties ---> Diastolic pressure
●Cardiovascular and Immune System - Vessel properties ---> Total peripheral resistance
●Nervous and regulatory systems - Endocrine function ---> Norepinephrine
●Nervous and regulatory systems - Endocrine function ---> Epinephrine
SLID-398 Space Food and Nutrition Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-399 Assessment of the Long-Term Stability of Retort Pouch Foods to Support Extended Duration Spaceflight Investigated Organism:
Organism Common Name:
Organism Class:
●n.a.
SLID-400 Detection of DNA damage by space radiation in human fibroblasts flown on the International Space Station Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Fibroblast cell;
●n.a.
 ●Radiation damage
 ●Omics - DNA damage ---> DNA double-strand break
SLID-401 A harness for enhanced comfort and loading during treadmill exercise in space Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Behavior;
●n.a.
 ●Pain
 ●Other profiles - Medication use ---> Exercise
SLID-402 Binocular misalignments elicited by altered gravity provide evidence for nonlinear central compensation Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Behavior;
●n.a.
 ●Visuo-motor disorder
 ●Nervous and regulatory systems - Neuro-sensory function ---> Binocular misalignments
SLID-403 CCISS, Vascular and BP Reg Canadian space life science research on ISS Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Heart; Vessel;
●Statistical physics of fluctuation system - Heartbeat fluctuation
●Fluid dynamics - Hemodynamics --->
●Arterial stiffness
●Cardiac rhythm disturbances
 ●Cardiovascular and Immune System - Heart rhythm ---> Heart rate
●Cardiovascular and Immune System - Heart rhythm ---> Heart rate variability
●Cardiovascular and Immune System - Vessel properties ---> Arterial baroreflex
●Cardiovascular and Immune System - Vessel properties ---> Arterial stiffness
SLID-404 Fluid shifts, vasodilatation and ambulatory blood pressure eduction during long duration spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Heart; Vessel;
●n.a.
 ●Unstable blood pressure
●Cardiac rhythm disturbances
 ●Cardiovascular and Immune System - Heart rhythm ---> Heart rate
●Cardiovascular and Immune System - Vessel properties ---> Blood pressure
●Cardiovascular and Immune System - Heart rhythm ---> Cardiac output
●Digestive and Excretory System - Urine components ---> Urine sodium
●Digestive and Excretory System - Urine components ---> Urine potassium
●Digestive and Excretory System - Urine components ---> Urine osmolality
SLID-405 Hemolysis contributes to anemia during long-duration space flight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Blood; Urine;
●n.a.
 ●Hemolysis
●Anemia
 ●Cardiovascular and Immune System - Blood components ---> Serum iron
●Cardiovascular and Immune System - Blood components ---> Ferritin
●Cardiovascular and Immune System - Blood components ---> Erythropoietin
●Cardiovascular and Immune System - Blood components ---> Carbon monoxide
SLID-406 Impact of communication delays to and from the International Space Station on self-reported individual and team behavior and performance: A mixed-methods study Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
●n.a.
 ●Mood impairment
 ●Nervous and regulatory systems - Psychology ---> Mood
●Nervous and regulatory systems - Psychology ---> Communication
SLID-407 Physiological and Functional Alterations after Spaceflight and Bed Rest Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Muscle;
●Statistical physics of fluctuation system - Heartbeat fluctuation
 ●Sensorimotor decline
 ●Nervous and regulatory systems - Neuromotor control ---> Kinetism
●Nervous and regulatory systems - Neuromotor control ---> Postural control
●Nervous and regulatory systems - Neuromotor control ---> Mobility
●Nervous and regulatory systems - Neuromotor control ---> Neuromuscular drive
●Musculoskeletal system - Muscle properties ---> Muscle strength
●Other profiles - Medication use ---> Exercise
●Cardiovascular and Immune System - Heart rhythm ---> Heart rate
●Cardiovascular and Immune System - Vessel properties ---> Blood pressure
●Cardiovascular and Immune System - Vessel properties ---> Plasma volume
SLID-408 Dietary acid load and bone turnover during long-duration spaceflight and bed rest Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Blood; Urine; Bone;
●n.a.
 ●Bone loss
 ●Musculoskeletal system - Bone properties ---> Bone mineral content
●Musculoskeletal system - Bone properties ---> Bone mineral density
●Digestive and Excretory System - Urine components ---> Urine Ca
●Digestive and Excretory System - Urine components ---> Urine N-telopeptide
●Cardiovascular and Immune System - Blood components ---> Bone-specific alkaline phosphatase
SLID-409 Effects of a Closed Space Environment on Gene Expression in Hair Follicles of Astronauts in the International Space Station Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Hair follicles;
●n.a.
 ●n.a.
 ●Omics - Transcriptome ---> Hair follicles
SLID-419 Biological and metabolic response in STS-135 space-flown mouse skin Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Skin;
●Oxidative damage
SLID-420 Decreased expression of myogenic transcription factors and myosin heavy chains in Caenorhabditis elegans muscles developed during spaceflight Investigated Organism: Caenorhabditis elegans;
Studied Organism Strains: Bristol N2;
Organism Common Name: Nematode;
Organism Class: Worm;
Studied Organ/Tissue/Part: Muscle; Whole animal;
●Muscle atrophy
SLID-422 Effects of Space Flight on Mouse Liver versus Kidney: Gene Pathway Analyses Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Liver; Kidney;
●n.a.
SLID-423 Effects of spaceflight on the muscles of the murine shoulder Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Muscle;
●n.a.
 ●Muscle atrophy
 ●Musculoskeletal system - Muscle properties ---> Muscle structure
●Musculoskeletal system - Muscle properties ---> Muscle proteins
●Omics - Proteome ---> Muscle
SLID-424 Evaluation of in vitro macrophage differentiation during space flight Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone marrow;
●n.a.
 ●Immune system dysregulation
 ●Cardiovascular and Immune System - Immune function ---> Blood cell population
●Omics - Transcriptome ---> Bone marrow
SLID-425 Exposure to microgravity for 30 days onboard Bion M1 caused muscle atrophy and impaired regeneration in murine femoral Quadriceps Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Muscle;
●n.a.
 ●Muscle atrophy
 ●Musculoskeletal system - Muscle properties ---> Muscle repair
●Musculoskeletal system - Muscle properties ---> Muscle proteins
●Musculoskeletal system - Muscle properties ---> Muscle structure
SLID-426 Fifteen days of microgravity causes growth in calvaria of mice Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Bone;
●n.a.
 ●Skeletal deformity
 ●Musculoskeletal system - Bone properties ---> Bone structure
●Musculoskeletal system - Bone properties ---> Mineral density
●Musculoskeletal system - Bone properties ---> Bone volume
SLID-427 Functional changes in the snail statocyst system elicited by microgravity Investigated Organism: Helix lucorum;
Organism Common Name: Snail;
Organism Class: Gastropoda;
Studied Organ/Tissue/Part: Vestibular organs; Nerve; Whole animal;
●n.a.
 ●n.a.
 ●Nervous and regulatory systems - Neuro-sensory function ---> Statocyst activity and response
●Nervous and regulatory systems - Behavior ---> Negative gravitaxis
●Nervous and regulatory systems - Neuro-sensory function ---> Nerve gene expression
SLID-428 Genetic models in applied physiology: selected contribution: effects of spaceflight on immunity in the C57BL/6 mouse. II. Activation, cytokines, erythrocytes, and platelets Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Blood; Whole animal; Spleen; Thymus;
●n.a.
 ●Immune system dysregulation
 ●Cardiovascular and Immune System - Immune function ---> Cytokine content
●Cardiovascular and Immune System - Blood contents ---> Erythrocytes
●Cardiovascular and Immune System - Blood contents ---> Platelets
●Cardiovascular and Immune System - Immune function ---> Blood cell differentials
●Other profiles - Organ morphology ---> Thymus mass
●Other profiles - Organ morphology ---> Spleen mass
●Nervous and regulatory systems - Behavior ---> Food consumption
●Nervous and regulatory systems - Behavior ---> Water consumption
SLID-429 Is spaceflight-induced immune dysfunction linked to systemic changes in metabolism? Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Spleen; Liver; Spleen; Adrenal gland;
●n.a.
 ●Immune system dysregulation
●Oxidative damage
 ●Cardiovascular and Immune System - Immune function ---> Blood cell population
●Cardiovascular and Immune System - Immune function ---> Splenocyte viability
●Omics - Metabolome ---> Liver
●Omics - Transcriptome ---> Liver
●Nervous and regulatory systems - Endocrine function ---> Adrenal hormones
SLID-430 Masticatory muscles of mouse do not undergo atrophy in space Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Muscle;
●n.a.
 ●Muscle atrophy
 ●Musculoskeletal system - Muscle properties ---> Muscle mass
●Musculoskeletal system - Muscle properties ---> Muscle gene expression and signaling
●Musculoskeletal system - Muscle properties ---> Muscle mechanics
SLID-431 Microarray analysis of spaceflown murine thymus tissue reveals changes in gene expression regulating stress and glucocorticoid receptors Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Thymus;
●n.a.
 ●Immune system dysregulation
 ●Omics - Transcriptome ---> Thymus
●Cardiovascular and Immune System - Immune function ---> Thymus gene expression and regulation
SLID-432 Preservation of Multiple Mammalian Tissues to Maximize Science Return from Ground Based and Spaceflight Experiments Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Multiple organs; Liver;
●n.a.
 ●n.a.
 ●Other profiles - Methodology ---> Tissue preservation
SLID-433 Prolonged Exposure to Microgravity Reduces Cardiac Contractility and Initiates Remodeling in Drosophila Investigated Organism: Drosophila melanogaster;
Organism Common Name: Fruit fly;
Organism Class: Arthropod;
Studied Organ/Tissue/Part: Heart;
●Statistical physics of fluctuation system - Heartbeat fluctuation
 ●Cardiomyopathies
 ●Cardiovascular and Immune System - Cardiovascular properties ---> Circadian rhythm
●Cardiovascular and Immune System - Cardiovascular properties ---> Heart remodeling
●Cardiovascular and Immune System - Cardiovascular properties ---> Heart structure
●Cardiovascular and Immune System - Cardiovascular properties ---> Heart morphology
●Omics - Transcriptome ---> Heart
SLID-434 Reduction of anabolic signals and alteration of osteoblast nuclear morphology in microgravity Investigated Organism: Mus musculus;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Osteoblast ;
●n.a.
 ●Bone loss
 ●Musculoskeletal system - Bone properties ---> Osteoblast gene expression
●Musculoskeletal system - Bone properties ---> Osteoblast morphology
SLID-435 Response of the mouse sublingual gland to spaceflight Investigated Organism:
Studied Organism Strains: C57BL/6;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Sublingual salivary gland;
●n.a.
 ●n.a.
 ●Nervous and regulatory systems - Endocrine function ---> Sublingual salivary glands morphology
●Nervous and regulatory systems - Endocrine function ---> Sublingual salivary glands protein expression
SLID-436 Retinal non-visual photoreception in space Investigated Organism: Mus musculus;
Studied Organism Strains: BALB/cJ,C57BL;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Eye;
●n.a.
 ●n.a.
 ●Nervous and regulatory systems - Eye properties ---> Retina cell survival
●Nervous and regulatory systems - Eye properties ---> Retina gene expression
SLID-437 Signs of Müller cell gliotic response found in the retina of newts exposed to real and simulated microgravity Investigated Organism: Pleurodeles waltl;
Organism Common Name: Newt;
Organism Class: Amphibian;
Studied Organ/Tissue/Part: Eye;
●n.a.
 ●Retinal gliosis
 ●Nervous and regulatory systems - Eye properties ---> Eye morphology
●Nervous and regulatory systems - Eye properties ---> Retina cell composition
SLID-438 Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early T-cell activation Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: T-cell; Spleen;
●n.a.
 ●n.a.
 ●Cardiovascular and Immune System - Immune function ---> T-cell activation
●Cardiovascular and Immune System - Immune function ---> Cytokine production
SLID-439 Spaceflight reduces vasoconstrictor responsiveness of skeletal muscle resistance arteries in mice Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Vessel;
●n.a.
 ●n.a.
 ●Cardiovascular and Immune System - Cardiovascular properties ---> Vasoconstrictor responsiveness
●Cardiovascular and Immune System - Cardiovascular properties ---> Blood pressure
●Cardiovascular and Immune System - Cardiovascular properties ---> Vessel gene expression
SLID-440 Spaceflight-induced synaptic modifications within hair cells of the mammalian utricle Investigated Organism: Mus musculus;
Studied Organism Strains: C57BL/6J;
Organism Common Name: Mice;
Organism Class: Mammalia;
Studied Organ/Tissue/Part: Hair cell;
●n.a.
 ●n.a.
 ●Nervous and regulatory systems - Neural properties ---> Synaptic modification
●Nervous and regulatory systems - Neuro-sensory function ---> Vestibular modification
SLID-441 Toll mediated infection response is altered by gravity and spaceflight in Drosophila Investigated Organism: Drosophila melanogaster;
Studied Organism Strains: Oregon-R wild-type;
Organism Common Name: Fruit fly;
Organism Class: Arthropod;
Studied Organ/Tissue/Part: Whole animal;
●n.a.
 ●Cardiovascular deconditioning
 ●Cardiovascular and Immune System - Immune function ---> Antibacterial response
●Omics - Transcriptome ---> Whole animal
SLID-414 Improvements in the re-flight of spaceflight experiments on plant tropisms Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Seed; Seedling;
●n.a.
 ●n.a.
 ●Growth - Seed germination ---> Germination rate
●Process - Phototropism ---> Red light
●Growth - Seed germination ---> Seedling length
●Growth - Seedling ---> Curvature
SLID-415 Microgravity does not alter plant stand gas exchange of wheat at moderate light levels and saturating CO2 concentration Investigated Organism: Triticum aestivum (Dwarf wheat);
Organism Common Name: n.a.;
Organism Class: Food;
Studied Organ/Tissue/Part: Leaf;
Food Category: Grain;
Growth Stage During Space Flight: Seed to mature plant;
●n.a.
 ●n.a.
 ●Process - Photosynthesis
●Growth - Leaf ---> Leaf area
SLID-416 Organ-specific remodeling of the Arabidopsis transcriptome in response to spaceflight Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Leaf; Root; Hypocotyl;
●n.a.
 ●n.a.
 ●Omics - Transcriptomics ---> Leaf
●Omics - Transcriptomics ---> Root
●Omics - Transcriptomics ---> Hypocotyl
●Growth - Seedling ---> Curvature
●Omics - Transcriptomics of stress resistance ---> Spaceflight adaptation
SLID-417 RNA-seq analyses of Arabidopsis thaliana seedlings after exposure to blue-light phototropic stimuli in microgravity Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Seedling;
●n.a.
 ●n.a.
 ●Environment - Artificial gravity
●Growth - Whole plant
●Process - Phototropism ---> Blue Light
●Omics - Transcriptomics ---> Seedling
●Process - Molecular pathway
SLID-418 Spaceflight transcriptomes: unique responses to a novel environment Investigated Organism: Arabidopsis thaliana;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Seedling; Tissue culture;
●n.a.
 ●n.a.
 ●Omics - Transcriptomics of stress resistance ---> Spaceflight adaptation
●Omics - Transcriptomics ---> Seedling
●Omics - Transcriptomics ---> Tissue culture
SLID-410 Fusarium oxysporum as an Opportunistic Fungal Pathogen on Zinnia hybrida Plants Grown on board the International Space Station Investigated Organism: Fusarium oxysporum;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Fungus;
Microbe Type: Plant opportunistic pathogen;
Microbe Form: Spacecraft sample;
●n.a.
 ●Virulence
 ●Other profiles - Microbial colonization on space crafts
●Omics - Genome
●Other profiles - Species identification
●Morphology - Mycelium
SLID-411 Metagenome to phenome approach enables isolation and genomics characterization of Kalamiella piersonii gen. nov., sp. nov. from the International Space Station Investigated Organism: Microbiota; Kalamiella piersonii;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Human opportunistic pathogen;
Microbe Form: Spacecraft sample;
●n.a.
 ●Antibiotic resistance
 ●Omics - Microbiome ---> Metagenome-resolved genomes
●Omics - Genome
●Other profiles - Species identification
●Cell behavior - Survival and growth ---> Growth rate
SLID-412 Nanosatellites for Biology in Space: In Situ Measurement of Bacillus subtilis Spore Germination and Growth after 6 Months in Low Earth Orbit on the O/OREOS Mission Investigated Organism: Bacillus subtilis;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Environmental microorganism;
Microbe Form: Spores;
●n.a.
 ●n.a.
 ●Environment - Hypergravity
●Environment - Radiation
●Cell behavior - Survival and growth
SLID-413 Spaceflight enhances cell aggregation and random budding in Candida albicans Investigated Organism: Candida albicans;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Fungus;
Microbe Type: Human opportunistic pathogen;
Microbe Form: Active organism;
●n.a.
 ●Microbial infection risk assessment
 ●Cell behavior - Survival and growth
●Omics - Transcriptome
●Cell behavior - Cluster
●Morphology - Cell
SLID-442 Effects of Space Flight on the Chemical Constituents and Anti-Inflammatory Activity of Licorice (Glycyrrhiza uralensis Fisch) Investigated Organism: Glycyrrhiza uralensis;
Organism Common Name: Licorice;
Organism Class: Herb;
Studied Organ/Tissue/Part: Seed; Root;
Food Category: n.a.;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Component - Active ingredients ---> Liquiritin contents
●Component - Active ingredients ---> Glycyrrhizic acid contents
●Component - Active ingredients ---> Anti-inflammatory effect
SLID-443 Effect of Spaceflight on Tomato Seed Quality and Biochemical Characteristics of Mature Plants Investigated Organism: Solanum lycopersicum;
Studied Organism Strains: Podmoskovny ranny of dwarf type;
Organism Common Name: Tomato;
Organism Class: Food;
Studied Organ/Tissue/Part: Whole plant ; Fruit ;
Food Category: Fruit ;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Growth - Seed germination
●Growth - Whole plant ---> Plant hight
●Growth - Whole plant ---> Crop cycle
●Growth - Flower ---> Flowering
●Growth - Fruit and seed ---> Fruit production
●Growth - Fruit and seed ---> Dry matter percentage
●Component - Active ingredients ---> Carotenoid content
●Component - Active ingredients ---> Antioxidant compounds and activity
●Component - Active ingredients ---> Organic acids
●Component - Carbohydrate ---> Monosaccharide
●Component - Mineral elements
●Quality - Taste index
●Quality - Yield
SLID-444 Research on lettuce growth technology onboard Chinese Tiangong II Spacelab Investigated Organism: Lactuca sativa;
Studied Organism Strains: Dasusheng;
Organism Common Name: Lettuce;
Organism Class: Food;
Studied Organ/Tissue/Part: Leaf;
Food Category: Vegetable;
Growth Stage During Space Flight: Seed to mature plant;
●n.a.
 ●n.a.
 ●Growth - Whole plant ---> Morphology
●Growth - Leaf ---> Leaf color
●Growth - Whole plant ---> Biomass
●Component - Mineral elements
●Quality - Yield
●Omics - Microbiota ---> Species composition
SLID-445 International Space Station environmental microbiome-microbial inventories of ISS filter debris Investigated Organism: Microbiota;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria/Fungus;
Microbe Type: Environmental microorganism;
Microbe Form: Spacecraft sample;
●n.a.
 ●n.a.
 ●Omics - Microbiome
●Omics - Spacecraft microbiome monitoring
●Other profiles - Microbial colonization on space crafts
SLID-446 Four-year bacterial monitoring in the International Space Station-Japanese Experiment Module "Kibo" with culture-independent approach Investigated Organism: Microbiota;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Environmental microorganism;
Microbe Form: Spacecraft sample;
●n.a.
 ●n.a.
 ●Omics - Microbiome
●Omics - Spacecraft microbiome monitoring
●Other profiles - Microbial colonization on space crafts
SLID-447 Survey of environmental biocontamination on board the International Space Station Investigated Organism: Microbiota;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria/Fungus;
Microbe Type: Environmental microorganism;
Microbe Form: Spacecraft sample;
●n.a.
 ●n.a.
 ●Omics - Microbiome
●Omics - Spacecraft microbiome monitoring
●Other profiles - Microbial colonization on space crafts
SLID-448 Bacterial monitoring with adhesive sheet in the international space station-"Kibo", the Japanese experiment module Investigated Organism: Microbiota;
Organism Common Name: n.a.;
Organism Class:
Organism Category: Bacteria;
Microbe Type: Environmental microorganism;
Microbe Form: Spacecraft sample;
●n.a.
 ●n.a.
 ●Omics - Microbiome
●Omics - Spacecraft microbiome monitoring
●Other profiles - Microbial colonization on space crafts
SLID-449 Effect of spaceflight on isoflavonoid accumulation in etiolated soybean seedlings Investigated Organism: Glycine max;
Organism Common Name: Soybean;
Organism Class: Food;
Studied Organ/Tissue/Part: Hypocotyl; Root; Seedling;
Food Category: Grain;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Growth - Root
●Growth - Seed germination
●Component - Secondary metabolites ---> Isoflavonoid
●Environment - Fractional gravity
SLID-450 Composition and physical properties of starch in microgravity-grown plants Investigated Organism: Glycine max; Solanum tuberosum L;
Organism Common Name: Soybean; Potato;
Organism Class: Food;
Studied Organ/Tissue/Part: Cotyledon; Hypocotyl; Stem;
Food Category: Grain;
Growth Stage During Space Flight: Seedling;
●n.a.
 ●n.a.
 ●Growth - Seed germination
●Growth - Leaf
●Component - Storage reserves ---> Starch
●Environment - Fractional gravity
SLID-451 Influence of Microgravity Environment on Root Growth, Soluble Sugars, and Starch Concentration of Sweetpotato Stem Cuttings Investigated Organism: Ipomoea batatas (L.) Lam.;
Studied Organism Strains: TU-82-155;
Organism Common Name: Sweetpotato;
Organism Class: Food;
Studied Organ/Tissue/Part: Root;
Food Category: Grain;
Growth Stage During Space Flight: Stem;
●n.a.
 ●n.a.
 ●Growth - Root
●Component - Storage reserves ---> Soluble Sugars
●Component - Storage reserves ---> Starch
●Environment - Fractional gravity
SLID-452 From seed-to-seed experiment with wheat plants under space-flight conditions Investigated Organism: Triticum aestivum (Super Dwarf wheat);
Organism Common Name: n.a.;
Organism Class: Food;
Studied Organ/Tissue/Part: Whole plant;
Food Category: Grain;
Growth Stage During Space Flight: Seed to mature plant;
●n.a.
 ●n.a.
 ●Component - Mineral elements
●Growth - Photosynthesis
●Growth - Whole plant
SLID-453 Metabolomics Analysis in Different Development Stages on SP0 Generation of Rice Seeds After Spaceflight Investigated Organism: Oryza sativa;
Studied Organism Strains: Dongnong423,Dongnong416;
Organism Common Name: Rice;
Organism Class: Food;
Studied Organ/Tissue/Part: Whole plant;
Food Category: Grain;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Growth - Whole plant
●Component - Storage reserves ---> Soluble Sugar
●Omics - Metabolomics
SLID-454 The Memory of Rice Response to Spaceflight Stress: From the Perspective of Metabolomics and Proteomics Investigated Organism: Oryza sativa;
Studied Organism Strains: Dongnong416;
Organism Common Name: Rice;
Organism Class: Food;
Studied Organ/Tissue/Part: Whole plant;
Food Category: Grain;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Growth - Whole plant
●Growth - Seed germination
●Omics - Metabolomics
●Component - Storage reserves
SLID-455 Combining Proteomics and Metabolomics to Analyze the Effects of Spaceflight on Rice Progeny Investigated Organism: Oryza sativa;
Studied Organism Strains: Dongnong423;
Organism Common Name: Rice;
Organism Class: Food;
Studied Organ/Tissue/Part: Whole plant;
Food Category: Grain;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Growth - Whole plant
●Growth - Seed germination
●Omics - Metabolomics
●Component - Storage reserves
SLID-456 Molecular Variation and Application from Aerospace Mutagenesis in Upland Rice Huhan 3 and Huhan 7 Investigated Organism: Oryza sativa;
Studied Organism Strains: Huhan 3,Huhan 3;
Organism Common Name: Rice;
Organism Class: Food;
Studied Organ/Tissue/Part: Whole plant;
Food Category: Grain;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Growth - Whole plant
●Growth - Seed germination
●Omics - Genetics and breeding
SLID-457 Germination, growth rates, and electron microscope analysis of tomato seeds flown on the LDEF Investigated Organism: Solanum lycopersicum;
Organism Common Name: Tomato;
Organism Class: Food;
Studied Organ/Tissue/Part: Seed; Leaf; Root;
Food Category: Fruit;
Growth Stage During Space Flight: Seed;
●n.a.
 ●n.a.
 ●Component - Mineral elements
●Growth - Seed germination
●Growth - Fruit and seed ---> Seed analysis
SLID-458 Molecular Basis to Integrate Microgravity Signals into the Photoperiodic Flowering Pathway in Arabidopsis thaliana under Spaceflight Condition Investigated Organism: Arabidopsis thaliana;
Studied Organism Strains: Col-0,pFT::GFP,ft-10;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Flower;
●n.a.
 ●n.a.
 ●Growth - Flower ---> Flowering
●Process - photoperiod
●Omics - Transcriptome
SLID-459 Transcriptomic Analysis of the Interaction Between FLOWERING LOCUS T Induction and Photoperiodic Signaling in Response to Spaceflight Investigated Organism: Arabidopsis thaliana;
Studied Organism Strains: Col-0;
Organism Common Name: Thale cress;
Organism Class: Model organism;
Studied Organ/Tissue/Part: Flower;
●n.a.
 ●n.a.
 ●Growth - Flower ---> Flowering
●Process - photoperiod
●Omics - Transcriptome
SLID-460 Human thermohomeostasis onboard “Mir” and in simulated microgravity studies Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Body temperature;
●Heat conduction - Body temperature
 ●Fever
 ●Nervous and regulatory systems - Body temperature ---> Oral
●Nervous and regulatory systems - Body temperature ---> Foot
●Nervous and regulatory systems - Body temperature ---> AWST
SLID-461 Body temperature and thermoregulation during submaximal exercise after 115-day spaceflight Investigated Organism: Homo sapiens;
Organism Common Name: Human;
Organism Class:
Studied Organ/Tissue/Part: Body temperature; Blood;
●Heat conduction - Body temperature
 ●Fever
 ●Nervous and regulatory systems - Body temperature ---> Core body temperature
●Nervous and regulatory systems - Body temperature ---> Thermoregulation
●Fluid dynamics - Hemodynamics