TCM Prescription: Sheng Xue Diao Wu Decoction



Prescription Description
Prescription IDTCMF5623
Pinyin NameSheng Xue Diao Wu Tang
Chinese Name升血调无汤
English NameSheng Xue Diao Wu Decoction
Function Description虚劳
IndicationsConsumptive disorder
Disease ICD-11 Category SD72 [Consumptive disorder (TM1), 虚劳 (TM1) ];
Human Tissues Associated with IndicationLung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1036 Spatholobus suberectus 鸡血藤 TCMH1036 ITSAK2607-14
TCMH700 Drynaria fortunei 骨碎补 TCMH700 GBVM3977-11
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH1430 Hordeum vulgare 麦芽 TCMH1430 ITSAI3101-14
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH619 Citrus medica var. sarcodactylis 佛手 TCMH619 ITSAJ4647-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT335 MPO Myeloperoxidase Oxidoreductase P05164
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT974 GPER1 G-protein coupled estrogen receptor 1 GPCR Q99527
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AR, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, GPER1, HSD17B2, IDO1, IGF1R, MMP2, MMP9, MPO, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR 10.5451
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GPER1, HCAR2, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH 10.1207
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GPER1, HCAR2, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TOP2A, XDH 10.0465
[BP] GO:0033993 response to lipid ALPL, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GPER1, HSD17B2, IDO1, MPO, PTGS2, RORC, SRC, TYR 9.90242
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GPER1, HCAR2, IDO1, IGF1R, KDR, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TOP2A, XDH 9.37029
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, HSD17B2, IDO1, IGF1R, KDR, MMP2, MPO, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR 9.1792
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GLO1, IDO1, MPO, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 9.04686
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 7.95699
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, HSD17B2, IDO1, IGF1R, KDR, MMP2, MMP9, MPO, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR 7.87567
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR, XDH 7.59728
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, IDO1, MPO, NQO2, PTGS1, PTGS2, TYR, XDH 7.59728
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR, XDH 7.49544
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC 7.20236
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, GPER1, PTGS2, RORC, SRC, TYR 7.19137
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.15681
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIM1, PTGS2, PTPN1, SRC 6.97302
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, HCAR2, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 6.8966
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GPER1, PPARA, PTGS2, SRC 6.892
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PIM1, PPARA, RORC, SRC 6.8533
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC, SRC 6.69899
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, IDO1, IGF1R, KDR, MMP9, MPO, PIK3CA, PIM1, PTGS2, PTPN1, SRC 6.25769
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GPER1, IGF1R, MMP2, PPARA, PTGS2, SRC 6.23555
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AR, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HSD17B2, KDR, MET, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TOP2A, TYR 6.1825
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.08684
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPER1, HCAR2, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 5.93605
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AR, CDC25B, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, GPER1, IDO1, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH 5.84839
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC, SRC 5.84132
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GPER1, HCAR2, HTR6, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.80867
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GPER1, HCAR2, HTR6, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.78381
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, AR, CYP1A1, CYP1B1, ESR1, FLT3, GPER1, PTGS2, RORC, SRC 5.23188
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.23188
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, GPER1, HCAR2, HSD17B1, HSD17B2, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, XDH 5.11531
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AR, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GPER1, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 5.10271
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PIK3CA, PPARA, SRC, TYR 5.09576
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 5.05562
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, IDO1, MMP1, MMP2, MMP9, MPO, PIK3CB, SRC, XDH 5.03683
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AR, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GPER1, IGF1R, KDR, MMP2, PIK3CA, PTGS2, RORC, SRC 4.95287
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, AR, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, HSD17B2, IDO1, IGF1R, KDR, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR 4.89718
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 4.80126
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 4.76463
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AR, AXL, CYP1B1, FLT3, GPER1, HTR6, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.74154
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.72531
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AR, AXL, CYP1B1, ESR1, GPER1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 4.51955
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1, HSD17B2 4.51955
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GPER1, HTR6, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.4436
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.36008
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AR, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, GPER1, HSD17B2, IDO1, IGF1R, MET, MMP1, MMP2, MMP9, MPO, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR 4.26706
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 4.2556
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GPER1, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, PTPN1, RORC, SRC, TOP2A 4.2374
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, GPER1, HCAR2, PPARA, PTGS2, RORC, SRC 4.17279
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.85573
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AR, AXL, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, GPER1, HTR6, IDO1, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.8474
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR, XDH 3.80297
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, HCAR2, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 3.79812
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, GPER1, HCAR2, HSD17B1, HSD17B2 3.79353
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR, XDH 3.74727
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.74316
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AR, AXL, CSNK2A1, CYP1B1, FLT3, GPER1, HTR6, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.69032
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.69032
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.686
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.62113
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MPO 3.62113
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.61022
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.52334
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 3.51709
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, MPO, PTGS1, PTGS2, SRC 3.49337
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, AR, CDC25B, ESRRB, FABP3, FLT3, GPER1, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.4628
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, AR, CDC25B, ESRRB, FABP3, FLT3, GPER1, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.4628
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GPER1, HCAR2, HTR6, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.45349
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 3.42186
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GPER1, HCAR2, HTR6, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.36176
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR 3.31754
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, AR, CDC25B, ESRRB, FLT3, GPER1, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.30613
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, GPER1, HCAR2, KDR, PIK3CB, PTGS2, SRC 3.27828
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, IDO1, PPARA, PTGS1, PTGS2 3.24998
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, IDO1 3.24487
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 3.24487
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.21082
[BP] GO:0042325 regulation of phosphorylation ADORA1, AR, CDC25B, ESRRB, FABP4, FLT3, GPER1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.16837
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.16837
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.13697
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CDC25B, CSNK2A1, ESR1, FLT3, GPER1, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS2 3.13193
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.10325
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AR, AXL, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD17B2, IDO1, MMP2, MMP9, PTGS2, SRC, TOP2A 3.10325
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, GPER1, MET, PIK3CA, PIK3CB, SRC 3.09065
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2 3.07093
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 3.07093
[BP] GO:0051896 regulation of protein kinase B signaling AXL, GPER1, MET, PIK3CA, PIK3CB, SRC, XDH 3.04165
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, GPER1, SRC 3.0407
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.0407
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, GPER1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.02489
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, AR, CDC25B, ESRRB, FABP3, FABP4, FLT3, GPER1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.02205
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AR, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 3.01935
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, AR, CDC25B, ESRRB, FABP3, FABP4, FLT3, GPER1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.98013
[BP] GO:0048545 response to steroid hormone ALPL, AR, CA2, FLT3, GPER1, PTGS2, SRC 2.97062
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, AOX1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO 2.96872
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, GPER1, IDO1, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A 2.96817
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, IDO1, PIK3CB 2.96817
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR 2.96622
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.9459
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, GPER1, HCAR2, PIK3CB, PTGS2 2.9042
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, AR, CDC25B, FLT3, GPER1, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.90417
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, IDO1, MPO, PIM1, PPARA, PTGS1, PTGS2, TYR 2.89746
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.86666
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.86666
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, IDO1, MPO, PIM1, PPARA, PTGS1, PTGS2, TYR 2.82407
[BP] GO:0009115 None AOX1, XDH 2.8175
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, GPER1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.81733
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 2.81733
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AR, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 2.80046
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.78689
[BP] GO:0006091 generation of precursor metabolites and energy AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 2.77689
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AR, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 2.76964
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, GPER1, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 2.76235
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AR, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 2.7575
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, GPER1, IGF1R, PPARA, PTGS2, SRC 2.67756
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 2.66917
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS1, PTGS2, TYR 2.66671
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.63283
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 2.63283
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, PTGS2, SRC 2.585
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.58154
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, ALDH2, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, IDO1, MPO, PIK3CB, SRC, XDH 2.58154
[BP] GO:0043065 positive regulation of apoptotic process CYP1B1, GPER1, HCAR2, IDO1, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.54361
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, GPER1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.53083
[BP] GO:0010676 None ESRRB, GPER1, PPARA, SRC 2.52418
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, AR, CDC25B, FABP4, FLT3, GPER1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.52418
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, GPER1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.52418
[BP] GO:0043068 positive regulation of programmed cell death CYP1B1, GPER1, HCAR2, IDO1, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.52001
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.50643
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.50465
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, FABP4, FLT3, GPER1, HTR6, IDO1, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.50249
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, FABP3, FLT3, GPER1, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 2.47477
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 2.45164
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.45164
[BP] GO:0046110 None AOX1, XDH 2.43518
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.43518
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.41988
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, ESR1, FABP4, GPER1, IDO1, PPARA, PTGS2 2.41271
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KDR, PTGS2, SRC 2.41271
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, PPARA, RORC, SRC, TOP2A 2.39553
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, AR, FLT3, GPER1, KDR, PIK3CB, PTPN1, SRC, XDH 2.39143
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.37049
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, ESR1, FABP4, GPER1, IDO1, MMP2, PPARA, PTGS2, PTPN1, SRC 2.36504
[BP] GO:1902532 negative regulation of intracellular signal transduction ESR1, GPER1, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.36124
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.34122
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.34122
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.33338
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1B1, KDR, SRC 2.33338
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, GPER1, PTGS2 2.32119
[BP] GO:0010675 None ESRRB, GPER1, PPARA, RORC, SRC 2.32119
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.31961
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.31961
[BP] GO:0010942 positive regulation of cell death CYP1B1, GPER1, HCAR2, IDO1, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.31286
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, GPER1, HCAR2, HSD17B1, HSD17B2, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR, XDH 2.3054
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.30274
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.30229
[BP] GO:0032355 response to estradiol CYP1A2, ESR1, ESRRA, GPER1, PTGS2 2.28971
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.27515
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, GPER1, MMP9, PTGS2, SRC, XDH 2.27127
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 2.25776
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.25776
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, GPER1, KDR, SRC 2.25416
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, FABP3, FLT3, GPER1, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 2.251
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, GPER1, MMP2, MMP9, PTGS2 2.23843
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.23784
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, AR, ESR1, FLT3, GPER1, IGF1R, MMP2, PTGS2, SRC 2.22613
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.22613
[BP] GO:0006145 None AOX1, XDH 2.22613
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.22613
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.22613
[BP] GO:0045913 None ESRRB, GPER1, PPARA, SRC 2.18306
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, AXL, GPER1, PIK3CA, PIK3CB, PTGS1, PTGS2 2.15301
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.13851
[BP] GO:0044283 None AKR1B1, ALOX5, CYP19A1, CYP1A1, IDO1, MPO, PTGS1, PTGS2 2.12916
[BP] GO:0043408 regulation of MAPK cascade ADORA1, AR, FLT3, GPER1, IGF1R, KDR, PIK3CB, PTPN1, SRC, XDH 2.07388
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, ALDH2, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, IDO1, XDH 2.06422
[BP] GO:0071383 None AR, FLT3, GPER1, SRC 2.05825
[BP] GO:2000108 None HCAR2, IDO1, PIK3CB 2.0426
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GPER1, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 2.03358
[BP] GO:0030263 None GPER1, TOP2A 2.03358
[BP] GO:0031401 positive regulation of protein modification process ADORA1, AR, CDC25B, FLT3, GPER1, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.03147
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2 2.02409
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, GPER1, MMP9, PTGS2, SRC, XDH 2.00897
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.00897
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, FABP3, KDR, PTGS2, SRC 2.00551
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APEX1, AR, AURKB, CA1, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, GPER1, HSD17B1, HSD17B2, IDO1, KDR, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 2.22613
[CC] GO:0043226 organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALPL, AOX1, APEX1, AR, AURKB, AXL, CA1, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, GPER1, HTR6, IDO1, IGF1R, KDR, MMP2, MMP9, MPO, NQO2, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SHBG, SRC, TOP2A, TYR, XDH 2.08152
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALPL, AOX1, APEX1, AR, AURKB, AXL, CA1, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, GPER1, IGF1R, KDR, MMP2, MMP9, MPO, NQO2, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SHBG, SRC, TOP2A, TYR, XDH 2.03358
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.9036
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AR, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, ESR1, FLT3, GLO1, GPER1, HCAR2, HTR6, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SRC 1.63362
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, TYR, XDH 14.2277
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR, XDH 10.5451
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.1207
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 9.90242
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, IDO1, MPO, NQO2, PTGS1, PTGS2, TYR, XDH 8.90234
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC 8.35048
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC 8.35048
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC 8.17908
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSD17B1, RORC, SHBG 7.9918
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC 7.80222
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, IDO1, MMP1, MMP2, MMP9, MPO, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, TOP2A, TYR, XDH 7.62611
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, IDO1, MMP1, MMP2, MMP9, MPO, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, TOP2A, TYR, XDH 7.256
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.10665
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS1, PTGS2, SRC 6.73385
[MF] GO:0048037 cofactor binding ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, IDO1, MPO, NQO2, PTGS1, PTGS2, SRC, XDH 6.71559
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.56976
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS1, PTGS2, SRC 6.49104
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 5.99903
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.49982
[MF] GO:0042562 hormone binding ACHE, AR, GPER1, HSD17B1, IGF1R, NQO2, SHBG 5.35016
[MF] GO:0008289 lipid binding AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, HSD17B1, PPARA, RORC, SHBG 4.23784
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, AOX1, XDH 4.06444
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2, GPER1 4.02917
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 3.75665
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.69032
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.686
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC 3.62113
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TOP2A 3.57769
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.50031
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.44683
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B1, HSD17B2, XDH 3.04816
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.0407
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC 3.04018
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.02432
[MF] GO:0097159 organic cyclic compound binding ADORA1, ALDH2, AOX1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HSD17B1, IDO1, IGF1R, KDR, MET, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SHBG, SRC, TOP2A, XDH 2.95276
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC 2.90417
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.8175
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.8175
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SRC 2.75494
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.73879
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.72754
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC 2.59698
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.50586
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.37548
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC 2.34122
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 2.33974
[MF] GO:0036094 small molecule binding ADORA1, ALDH2, AOX1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TOP2A, XDH 2.31371
[MF] GO:1901363 heterocyclic compound binding ADORA1, ALDH2, AOX1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IDO1, IGF1R, KDR, MET, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 2.28971
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.22613
[MF] GO:0005497 None AR, SHBG 2.22613
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.12779
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.11564
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.08152


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.6893
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.2355
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, GPER1, PIK3CB, MMP9, ESR1, ESR2 7.4131
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 7.0146
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.4139
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 6.28
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, FUT7, AKR1B10, ALDH2, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1 5.574
Pathways in cancer_Homo sapiens_hsa05200 AR, PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, MET, IGF1R 5.195
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.2534
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.6994
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.3808
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.3594
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, HTR6, PIK3CA, ADORA1, PIK3CB, PPARA 3.4538
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 3.4538
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.4815
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.4538
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.0244
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.373
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.3363
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.2808
Prostate cancer_Homo sapiens_hsa05215 AR, PIK3CA, PIK3CB, IGF1R 2.9743
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3083
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, PIM1, PIK3CB 2.8277
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.1606
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.8626
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, MPO, IGF1R 2.8626
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2 3.0945
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.7151
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.716
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, ALOX5, PTGS2, PTGS1 2.6992
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, IGF1R 2.5312
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.6099
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.6398
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.6398
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, ADORA1, PIK3CB 2.6247
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.4089
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, PIK3CB, MMP9 2.4055
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, AOX1, PIK3CB 2.3076
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.3076
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 2.2375
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.4055
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.4055
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, KDR, PIK3CB, MET, IGF1R 1.9454
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.4699
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, PTGS1 2.4184
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.9897
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.9416
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 2.0326
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.4016
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 2.1196
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, PIK3CB 1.8768
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.4055
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, PIK3CB, IGF1R 1.9454
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2 2.1255
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.7016
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.303
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB 1.8173
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.7726
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.7086
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.7086
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.7016
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.6819
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.6089
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB 1.3458
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.4142
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.3343
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.2915
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2603
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1101
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR6, ADORA3, ADORA1 1.0719
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3631
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3554
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6 0.3614
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3623
Phagosome_Homo sapiens_hsa04145 MPO 0.4048
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4298
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB 0.9851
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9863
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.0044
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, PIK3CB 0.9566
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.0173
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 0.9718
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.6451
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PIK3CB 1.0776
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4719
Axon guidance_Homo sapiens_hsa04360 MET 0.4662
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2443
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.1853
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.2366
Oocyte meiosis_Homo sapiens_hsa04114 AR, IGF1R 1.0671
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.1713
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.1653
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.1885
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.1713
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.1998
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.871
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.2366
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5436
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5436
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5546
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5436
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5536
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.4336
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.4018
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5677
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5688
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.4018
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5712
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5712
Gap junction_Homo sapiens_hsa04540 SRC 0.5712
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.4417
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5699
Peroxisome_Homo sapiens_hsa04146 XDH 0.584
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.4142
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.5086
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4336
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.427
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, PIK3CB 1.4873
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6271
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6251
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.637
Bile secretion_Homo sapiens_hsa04976 CA2 0.6347
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.5599
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.6098
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6562
Shigellosis_Homo sapiens_hsa05131 SRC 0.6562
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.6476
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6562
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6776
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.6704
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.7016
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.7802
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.7312
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2, AOX1 1.6704
Malaria_Homo sapiens_hsa05144 MET 0.7481
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2 0.7435
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7615
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9519
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7667
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2, GLO1 1.7726
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.7812
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.8579
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9197
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.871
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1397
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.9101
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8881
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.9266
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.9101
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.9266
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9566
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.9165
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9488
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.9488
Histidine metabolism_Homo sapiens_hsa00340 ALDH2 0.9784
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1707
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1653
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.4336


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)