TCM Prescription: Huo Xin Pills



Prescription Description
Prescription IDTCMF4366
Pinyin NameHuo Xin Wan
Chinese Name活心丸
English NameHuo Xin Pills
Function Description胸痹, 真心痛
IndicationsTrue heart pain disorder, Chest pain
Disease ICD-11 Category SA20 [True heart pain disorder (TM1), 真心痛 (TM1) ];
MD30.Z [Chest pain, unspecified, 胸痛，未特指的 ];
Human Tissues Associated with IndicationHeart, Lung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1299 Ganoderma lucidum 灵芝 TCMH1299 MGEN736-15
TCMH1880 Moschus moschiferus 麝香 TCMH1880 GBMA2112-09
TCMH2327 Conyza blinii 熊胆 TCMH2327
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH1573 Bovis calculus 牛黄 TCMH1573
TCMH2605 Margarita 珍珠 TCMH2605
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH233 Bufonis venenum 蟾酥 TCMH233
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
TCMH183 Dryobalanops aromatica 冰片 TCMH183 GBVK4926-11
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT203 G6PD Glucose-6-phosphate 1-dehydrogenase Oxidoreductase P11413
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT974 GPER1 G-protein coupled estrogen receptor 1 GPCR Q99527
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1351 Nocardia sp.
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FDPS, FUT7, HSD17B1, HSD17B2, HSD17B3, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 10.4508
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FDPS, FUT7, GLO1, HSD17B3, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 9.92914
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GPER1, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH 8.60535
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 8.56692
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GPER1, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TOP2A, XDH 8.53684
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, AR, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, ESRRA, FABP3, GPER1, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PTGS2, SRC, TYR 8.35442
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 8.05271
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 8.04268
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GPER1, HCAR2, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TOP2A, XDH 7.99711
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FDPS, HSD17B1, HSD17B2, HSD17B3 7.77514
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7, CA9 7.73113
[BP] GO:0010033 response to organic substance AKR1B1, APEX1, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, HSD17B2, IGF1R, KDR, MMP2, PIK3CA, PPARA, PTGS2, SRC, TYR 7.14294
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, HSD17B2, HSD17B3, NQO2, PTGS1, PTGS2, TYR, XDH 6.8221
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 6.71899
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD3, ESR1, FABP3, FABP4, FLT3, GPER1, HCAR2, HSD17B1, HSD17B2, HSD17B3, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, XDH 6.47358
[BP] GO:0033993 response to lipid AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GPER1, HSD17B2, PTGS2, SRC, TYR 6.42362
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FDPS, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 6.4081
[BP] GO:0014070 response to organic cyclic compound APEX1, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, ESRRA, FLT3, GPER1, PTGS2, SRC, TYR 6.4081
[BP] GO:0009725 response to hormone AKR1B1, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GPER1, PPARA, PTGS2, SRC 6.04259
[BP] GO:0042221 response to chemical AKR1B1, APEX1, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, SRC, TYR 6.04219
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 5.99008
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AR, CDC25B, CSNK2A1, CYP1B1, DRD3, ESR1, ESRRA, FABP3, FLT3, GPER1, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH 5.92741
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, HSD17B3, KDR, PIK3CA, PPARA, SRC, TYR 5.91281
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH 5.91281
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, FLT3, GPER1, HCAR2, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.90196
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, FLT3, GPER1, HCAR2, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.87833
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC 5.71771
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PIM1, PPARA, SRC 5.70762
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GPER1, IGF1R, MMP2, PPARA, PTGS2, SRC 5.52348
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 5.51576
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, SRC 5.46519
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC 5.4583
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HSD17B2, HSD17B3, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TOP2A, TYR 5.23789
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, FDPS, HSD17B1, HSD17B2, HSD17B3, PIK3CA, PIK3CB, PTGS1, PTGS2 5.23789
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FDPS, FLT3, GPER1, HCAR2, PPARA, PTGS2, SRC 5.18981
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 5.16244
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 5.15515
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPER1, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH 5.14063
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 5.07867
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 4.89616
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC 4.80343
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, SRC 4.76325
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, GPER1, HCAR2, HSD17B1, HSD17B2, HSD17B3 4.76325
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, DRD3, FABP3, PPARA 4.66457
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, DRD3, ESR1, FLT3, GPER1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.60894
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD3, GPER1, HCAR2, KDR, PIK3CB, PTGS2, SRC 4.12527
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AR, AXL, CYP1B1, FLT3, GPER1, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.0969
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD3, GPER1, MET, PIK3CA, PIK3CB, SRC, XDH 4.03452
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AR, AURKB, AXL, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR 4.00516
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH 4.00262
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 4.00262
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.95883
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APEX1, AR, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GPER1, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, SRC 3.92193
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, PIK3CB, SRC, XDH 3.92193
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD3, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 3.92193
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CDC25B, CSNK2A1, DRD3, ESR1, FLT3, GPER1, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS2 3.8803
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AR, AXL, CYP1B1, ESR1, GPER1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, SRC 3.87085
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD3, GPER1, HCAR2, PIK3CB, PTGS2 3.86526
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 3.84766
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AR, AXL, CSNK2A1, CYP1B1, DRD3, FLT3, GPER1, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.83492
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, CA12, CA2, CA7, DRD3, ESR1, FABP3, FABP4, FLT3, GPER1, MET, PIK3CA, PIK3CB, SRC 3.78825
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 3.75309
[BP] GO:0071310 cellular response to organic substance AKR1B1, APEX1, AR, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GPER1, IGF1R, KDR, MMP2, PIK3CA, PTGS2, SRC 3.72457
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.66822
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 3.66822
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, AR, CDC25B, DRD3, ESRRB, FABP3, FABP4, FLT3, GPER1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.66716
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, DRD3, FABP3, PPARA 3.66179
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, AR, CDC25B, DRD3, ESRRB, FABP3, FABP4, FLT3, GPER1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.62345
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, ESR1, ESR2, FLT3, GPER1, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.62118
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 3.62118
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FDPS 3.62118
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH 3.62054
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.61462
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, AR, CDC25B, ESRRB, FABP3, FLT3, GPER1, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.59411
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, AR, CDC25B, ESRRB, FABP3, FLT3, GPER1, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.59411
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, ESR1, ESR2, FLT3, GPER1, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.5515
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2, HSD17B3 3.5515
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, AR, CYP1A1, CYP1B1, ESR1, FLT3, GPER1, PTGS2, SRC 3.52774
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AR, AXL, CSNK2A1, CYP1B1, DRD3, ESRRA, FABP4, FLT3, GPER1, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.5093
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, NQO2, PTGS1 3.5093
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, AR, CDC25B, ESRRB, FLT3, GPER1, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.43283
[BP] GO:0051716 cellular response to stimulus AKR1B1, APEX1, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GPER1, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, PTPN1, SRC, TOP2A 3.35596
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, PPARA, PTGS1, PTGS2 3.35596
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, GPER1, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 3.35596
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HSD17B3 3.31871
[BP] GO:0042325 regulation of phosphorylation ADORA1, AR, CDC25B, ESRRB, FABP4, FLT3, GPER1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.30496
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FDPS 3.30231
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.30125
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, FDPS, HSD17B1, HSD17B2, HSD17B3 3.28948
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.24503
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD3, GPER1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.22069
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.20297
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD3, FABP3, FLT3, GPER1, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.17411
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AR, AURKB, CDC25B, CSNK2A1, DRD3, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH 3.16134
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD3, GPER1, KDR, SRC 3.1589
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, GPER1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.11614
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD3, ESR1, GPER1, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.11173
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, GPER1, SRC 3.10383
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.09631
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR 3.04095
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1B1, DRD3, FDPS, HSD17B3, TYR 3.03943
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, HSD17B3, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TYR 3.03411
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 3.01127
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, AR, AXL, CYP19A1, CYP1A2, CYP1B1, DRD3, ESR1, ESRRB, FABP4, GPER1, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TYR 3.0085
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, AR, CDC25B, FLT3, GPER1, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.98972
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.93881
[BP] GO:0008217 None ADORA1, AR, DRD3, PPARA, PTGS1, PTGS2 2.93881
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AR, AURKB, CDC25B, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH 2.92516
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.89936
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD3, FABP3, FLT3, GPER1, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 2.89936
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AR, AURKB, CDC25B, CSNK2A1, DRD3, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH 2.8973
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, GPER1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.89467
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AR, AURKB, CDC25B, CSNK2A1, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH 2.891
[BP] GO:0009115 None AOX1, XDH 2.84935
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.81975
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 2.80291
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, PTGS1, PTGS2, SRC 2.78244
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.77771
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 2.74235
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, GPER1, IGF1R, PPARA, PTGS2, SRC 2.73896
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, AR, AURKB, CSNK2A1, CYP2D6, DRD3, ESR1, ESR2, ESRRA, FABP4, GPER1, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, SRC, XDH 2.72285
[BP] GO:0022414 reproductive process AKR1B1, AR, AXL, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD17B2, HSD17B3, MMP2, MMP9, PTGS2, SRC, TOP2A 2.68434
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.66477
[BP] GO:0003006 developmental process involved in reproduction AR, AXL, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, HSD17B3, PTGS2, SRC 2.65459
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, DRD3, FABP3, KDR, PTGS2, SRC 2.65269
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.6308
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, GLO1, GPER1, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH 2.62174
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, AR, CDC25B, FABP4, FLT3, GPER1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.61634
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, GPER1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.60163
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD3, ESR1, ESR2, FABP4, FLT3, GPER1, IGF1R, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 2.57425
[BP] GO:0010676 None ESRRB, GPER1, PPARA, SRC 2.56255
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, ESR1, HSD17B2, HSD17B3, SRC 2.56081
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.56081
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APEX1, AURKB, AXL, CDC25B, CSNK2A1, FDPS, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 2.55558
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.54912
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.49482
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.46056
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KDR, PTGS2, SRC 2.45895
[BP] GO:0046110 None AOX1, XDH 2.45895
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.45895
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, AR, FLT3, GPER1, KDR, PIK3CB, PTPN1, SRC, XDH 2.44938
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD3, ESR1, PPARA, SRC, TOP2A 2.44682
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.4157
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, DRD3, ESR1, FABP3, FABP4, GPER1, MET, PIK3CA, PIK3CB 2.41062
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 2.39953
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6 2.39387
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, DRD3, KDR, SRC 2.38973
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, DRD3, ESR1, ESR2, GPER1, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.38973
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, DRD3, ESR1, ESR2, GPER1, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.38155
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.38155
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.38155
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.38155
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD3 2.37674
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, GPER1, PTGS2 2.36857
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.35832
[BP] GO:0006793 phosphorus metabolic process ACHE, APEX1, AURKB, AXL, CDC25B, CSNK2A1, FDPS, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 2.35281
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 2.35281
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GPER1, HCAR2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 2.34503
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.34503
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD3, GPER1, PTGS2 2.34074
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD3, GPER1, PTGS2 2.34074
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.34074
[BP] GO:0032355 response to estradiol CYP1A2, ESR1, ESRRA, GPER1, PTGS2 2.33648
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, AR, CYP19A1, DRD3, ESR1, ESR2, GPER1, IGF1R, MET, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.3362
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 2.33576
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, GPER1, MMP9, PTGS2, SRC, XDH 2.32791
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.32791
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD3, ESR1, ESR2, ESRRA, FABP4, FLT3, GPER1, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.31427
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, GLO1, GPER1, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH 2.29718
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.29718
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, AR, ESR1, FLT3, GPER1, IGF1R, MMP2, PTGS2, SRC 2.29552
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, GPER1, MMP2, MMP9, PTGS2 2.28866
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AR, AURKB, CDC25B, CSNK2A1, DRD3, ESR1, FABP4, FLT3, GPER1, IGF1R, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.27604
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.25383
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.25383
[BP] GO:0006145 None AOX1, XDH 2.25383
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.25383
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.25383
[BP] GO:0045913 None ESRRB, GPER1, PPARA, SRC 2.22619
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, AXL, GPER1, PIK3CA, PIK3CB, PTGS1, PTGS2 2.21973
[BP] GO:0048545 response to steroid hormone AR, CA2, FLT3, GPER1, PTGS2, SRC 2.21333
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.20139
[BP] GO:0044283 None AKR1B1, ALOX5, CYP19A1, CYP1A1, FDPS, HSD17B3, PTGS1, PTGS2 2.19785
[BP] GO:0043408 regulation of MAPK cascade ADORA1, AR, FLT3, GPER1, IGF1R, KDR, PIK3CB, PTPN1, SRC, XDH 2.14687
[BP] GO:0031401 positive regulation of protein modification process ADORA1, AR, CDC25B, FLT3, GPER1, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.1101
[BP] GO:0071383 None AR, FLT3, GPER1, SRC 2.09882
[BP] GO:0008209 androgen metabolic process CYP19A1, ESR1, HSD17B3 2.07652
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, GPER1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A 2.06973
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2 2.06219
[BP] GO:0061370 testosterone biosynthetic process CYP19A1, HSD17B3 2.06219
[BP] GO:0030263 None GPER1, TOP2A 2.06219
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, GPER1, MMP9, PTGS2, SRC, XDH 2.05793
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.03971
[BP] GO:0035265 organ growth AR, CYP19A1, ESR1 2.00092
[BP] GO:0009891 positive regulation of biosynthetic process AR, AURKB, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, IGF1R, KDR, MET, PPARA, PTGS2, SRC, TOP2A 2.00092
[BP] GO:0043065 positive regulation of apoptotic process CYP1B1, GPER1, HCAR2, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.00092
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AR, AURKB, CA1, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD3, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GPER1, HSD17B1, HSD17B2, HSD17B3, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 2.91096
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, AOX1, APEX1, AR, AURKB, AXL, CA1, CA2, CA4, CA6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GPER1, HSD17B3, IGF1R, KDR, MMP2, MMP9, NQO2, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SHBG, SRC, TOP2A, TYR, XDH 2.71584
[CC] GO:0005783 None ADORA1, APEX1, CA4, CYP19A1, CYP2D6, FLT3, GPER1, HSD17B3, KDR, PTGS2, PTPN1, XDH 2.41951
[CC] GO:0043226 organelle ACHE, ADORA1, AKR1B1, AKR1B10, AOX1, APEX1, AR, AURKB, AXL, CA1, CA2, CA4, CA6, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GPER1, HSD17B3, IGF1R, KDR, MMP2, MMP9, NQO2, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SHBG, SRC, TOP2A, TYR, XDH 1.9608
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.93239
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, AR, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, TYR, XDH 15.6532
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 12.3741
[MF] GO:0043167 ion binding ACHE, ALOX5, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 11.2352
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 10.2257
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 8.40627
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP2, MMP9, NQO2, PPARA, PTPN1 8.22382
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, HSD17B2, HSD17B3, NQO2, PTGS1, PTGS2, TYR, XDH 8.04879
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 8.04268
[MF] GO:0043169 cation binding ACHE, ALOX5, AOX1, APEX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD3, ESR1, ESR2, ESRRA, ESRRB, FDPS, GLO1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, TOP2A, TYR, XDH 7.88999
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA 6.8221
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA 6.8221
[MF] GO:0046872 metal ion binding ALOX5, AOX1, APEX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, FDPS, GLO1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, TOP2A, TYR, XDH 6.8221
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSD17B1, SHBG 6.66357
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, GLO1 6.65429
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA 6.36171
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, SRC 5.50911
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.4199
[MF] GO:0042562 hormone binding ACHE, AR, GPER1, HSD17B1, IGF1R, NQO2, SHBG 5.40943
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, SRC 5.29605
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.1821
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, TYR 4.97192
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 4.97192
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD3, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TOP2A 4.95626
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, XDH 4.89158
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B1, HSD17B2, HSD17B3, XDH 4.13903
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.05658
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2, GPER1 4.05658
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 3.86526
[MF] GO:0008289 lipid binding AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, HSD17B1, PPARA, SHBG 3.61532
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.61462
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.52407
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, DRD3, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HCAR2, IGF1R, KDR, MET, PPARA 3.17411
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.09631
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.0864
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.84935
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.84935
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SRC 2.8308
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.80361
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD3, ESR1, ESR2, ESRRA, ESRRB, FDPS, FLT3, GPER1, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SHBG, SRC, TOP2A, XDH 2.77191
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, DRD3, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HCAR2, IGF1R, KDR, MET, PPARA 2.63086
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.55558
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, DRD3, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HCAR2, IGF1R, KDR, MET, PPARA 2.49324
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.44656
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC 2.41051
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 2.40067
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD17B1, HSD17B2, HSD17B3 2.38973
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.25383
[MF] GO:0005497 None AR, SHBG 2.25383
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, DRD3, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HCAR2, IGF1R, KDR, MET, PPARA 2.24907
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.19785
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD17B1, HSD17B2, HSD17B3 2.11932
[MF] GO:0016229 steroid dehydrogenase activity HSD17B1, HSD17B2, HSD17B3 2.04075


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14 13.7891
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.7799
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, GPER1, PIK3CB, MMP9, ESR1, ESR2 7.6276
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 7.6488
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.5096
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 6.3547
Pathways in cancer_Homo sapiens_hsa05200 AR, PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, MET, IGF1R 5.186
Metabolic pathways_Homo sapiens_hsa01100 FDPS, HSD17B3, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH 4.95
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.7206
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.406
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.3883
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.0929
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 3.4994
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.4994
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.5409
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.42
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.084
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.372
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.3188
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2D6, CYP1A2, CYP1A1, CYP1B1 3.2926
Prostate cancer_Homo sapiens_hsa05215 AR, PIK3CA, PIK3CB, IGF1R 3.0332
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, PIM1, PIK3CB 2.8551
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3452
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.8891
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.2196
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, PIK3CA, ADORA1, PIK3CB, PPARA 2.7595
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.7595
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2 3.1535
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.7595
Serotonergic synapse_Homo sapiens_hsa04726 CYP2D6, ALOX5, PTGS2, PTGS1 2.744
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, IGF1R 2.5832
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.6851
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.656
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.6851
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, ADORA1, PIK3CB 2.6704
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, PIK3CB, MMP9 2.4427
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.4445
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, AOX1, PIK3CB 2.3559
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.3559
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 2.277
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.4427
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.4427
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1763
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, KDR, PIK3CB, MET, IGF1R 1.9961
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, PTGS1 2.4475
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.4338
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 2.0329
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 2.0758
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 2.1627
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.4427
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, PIK3CB 1.9205
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2, AOX1 2.3877
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2 2.1685
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, PIK3CB, IGF1R 1.9961
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.7464
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB 1.8684
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.7528
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.8228
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.7528
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.7447
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.6474
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.7265
Influenza A_Homo sapiens_hsa05164 FDPS, PIK3CA, PIK3CB 1.5056
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB 1.3906
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.4571
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.379
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.3361
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2649
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3603
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3707
Tuberculosis_Homo sapiens_hsa05152 SRC 0.37
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1545
HTLV-I infection_Homo sapiens_hsa05166 FDPS, PIK3CA, PIK3CB 1.1786
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, DRD3 1.1162
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4403
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB 1.0288
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.479
Axon guidance_Homo sapiens_hsa04360 MET 0.4735
Dopaminergic synapse_Homo sapiens_hsa04728 DRD3 0.4711
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.044
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.0569
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.0301
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, PIK3CB 0.9948
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 1.0116
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PIK3CB 1.1172
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2837
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.2005
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.2248
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.2761
Oocyte meiosis_Homo sapiens_hsa04114 AR, IGF1R 1.1067
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.2109
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.228
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.2109
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.2393
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5508
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5508
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.561
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.2761
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5508
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5602
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.574
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5748
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5768
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5768
Gap junction_Homo sapiens_hsa04540 SRC 0.5768
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.4413
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5758
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.4413
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.4782
Peroxisome_Homo sapiens_hsa04146 XDH 0.5889
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.4862
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.4536
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.5476
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6315
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6297
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6409
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4782
Bile secretion_Homo sapiens_hsa04976 CA2 0.6388
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, PIK3CB 1.5264
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.5929
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5556
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.6474
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.669
Shigellosis_Homo sapiens_hsa05131 SRC 0.6666
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.691
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.7031
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.7447
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.8254
Malaria_Homo sapiens_hsa05144 MET 0.7683
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7778
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7729
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7828
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9961
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.8959
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.957
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8791
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.8359
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1763
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.9333
Base excision repair_Homo sapiens_hsa03410 APEX1 0.9112
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.957
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.957
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.991
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9792
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 1.0408
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2196
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.4782


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)