TCM Prescription: He Gan Li Dan Infusion



Prescription Description
Prescription IDTCMF4298
Pinyin NameHe Gan Li Dan Chong Ji
Chinese Name和肝利胆冲剂
English NameHe Gan Li Dan Infusion
Function Description黄疸
IndicationsJaundice disorder, Jaundice
Disease ICD-11 Category SA01 [Jaundice disorder (TM1), 黄疸 (TM1) ];
ME10.1 [Unspecified jaundice, 未特指的黄疸 ];
Human Tissues Associated with IndicationLiver
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1114 Herba glechomae longitubae 金钱草 TCMH1114
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1333 Human rhinovirus 1A
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, KIT, MET, PPARA, PTGS2, TBXAS1, TRPV1 12.0153
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, FABP3, FABP4, FLT3, GSK3B, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, POLB, PPARA, PTGS2, SRC, TERT, TOP1, TRPV1, TYR 10.952
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, FABP3, GSK3B, HSD17B2, IDO1, IGF1R, MMP2, MMP9, NR3C1, POLB, PPARA, PTGS2, SRC, TRPV1, TYR 10.6619
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, FABP3, FABP4, FLT3, GSK3B, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, NR3C1, POLB, PPARA, PTGS2, SRC, TRPV1, TYR 10.3444
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, AKR1C3, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, F10, FABP3, FABP4, FLT3, GSK3B, HSD11B1, HSD17B1, HSD17B2, KDR, KIT, MET, POLA1, POLB, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 10.3034
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DYRK1A, F10, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD11B1, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TRPV1, TYR, XDH 9.74755
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, FABP3, FUT7, IDO1, PIM1, PPARA, PTGS2, TBXAS1, TYR, XDH 9.66277
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, GSK3B, HSD11B1, HSD17B1, HSD17B2, IDO1, PTGS2, TBXAS1, TYR, XDH 9.48454
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 9.45628
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PTGS2, SRC, TERT 9.3608
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 8.70492
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 8.42248
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DYRK1A, F10, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, NR3C1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 8.1664
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 8.00091
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, FABP3, FLT3, GSK3B, IGF1R, KIT, MMP2, NR3C1, PPARA, PTGS2, SRC, TRPV1 7.90793
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9, DHFR 7.40955
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 7.25194
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, KIT, MET, PPARA, PTGS2, TBXAS1 7.19698
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 7.19194
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PTGS2, SRC, TERT, TRPV1 7.11371
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, GSK3B, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 7.01193
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, GSK3B, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 6.98907
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DYRK1A, F10, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD11B1, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TRPV1, TYR, XDH 6.98033
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 6.91702
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.91221
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, IDO1, NR3C1, PTGS2, SRC, TYR 6.66191
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, NR3C1, PTGS2, SRC, TRPV1, TYR 6.62856
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TERT 6.58942
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS2, TBXAS1 6.57233
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DYRK1A, FABP4, FLT3, FUT7, GSK3B, HSD11B1, HSD17B2, KDR, KIT, MET, MMP2, MMP9, PIM1, POLB, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS2, TYR 6.51177
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, NR3C1, PTGS2, SRC, TRPV1 6.49722
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TERT, TRPV1, XDH 6.46323
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, SRC, TERT 6.41703
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, KIT, NR3C1, PPARA, PTGS2, SRC, TRPV1 6.39645
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, POLA1, POLB, PTGS2, SRC, TERT, TRPV1 6.38716
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, SRC, TERT, TRPV1, XDH 6.38199
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 6.38199
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGS2, TERT 6.32421
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DYRK1A, F10, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD11B1, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TRPV1, TYR, XDH 6.31758
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, F10, FABP3, FABP4, FLT3, GSK3B, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, POLA1, POLB, PPARA, PTGS2, SRC, TERT, TOP1, TRPV1, TYR 6.2763
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, PIM1, SRC 6.18928
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, TYR 6.14897
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 6.14897
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX12, APP, BCL2, CSNK2A1, CYP1B1, DNMT1, FABP3, FLT3, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTGS2, SRC, TERT, XDH 5.86714
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DHFR, FABP3, KDR, NR3C1, POLB, PTGS2, SRC, TOP1, TRPV1 5.84323
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 5.83342
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, F10, FLT3, GSK3B, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 5.74995
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DYRK1A, FLT3, GSK3B, HSD11B1, HSD17B2, KDR, KIT, MMP9, PIM1, POLB, PPARA, PTGS2, PTPRS, SRC, TYR 5.73542
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, AKR1C3, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DNMT1, DYRK1A, F10, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 5.59237
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 5.57619
[BP] GO:0032787 None AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PPARA, PTGS2, TBXAS1 5.46915
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, F10, FABP3, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 5.46915
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD11B1, HSD17B2, KDR, KIT, POLB, PPARA, PTPRS, SRC, TYR 5.29767
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 5.22491
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, DHFR, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, POLB, PTGS2, PTPRS, SRC, TNKS, TOP1, XDH 5.1576
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, GSK3B, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, SRC, TERT, TRPV1, XDH 5.1214
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, F10, FABP4, HSD17B2, IDO1, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, SRC, TNKS2, TOP1, TRPV1, TYR 5.04019
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, SRC, TERT 5.03538
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PIM1, PPARA, PTGS2, TBXAS1, TYR 5.01624
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, F10, FABP4, FLT3, GSK3B, IDO1, KDR, KIT, MET, MMP2, MMP9, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 5.00647
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, BCL2, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.96759
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, GSK3B, MET, MMP9, PPARA, SRC, TERT 4.9673
[BP] GO:0019371 None AKR1C3, CBR1, PTGS2, TBXAS1 4.92837
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, DHFR, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, POLB, PTGS2, PTPRS, SRC, TNKS, TOP1, XDH 4.84853
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, PTGS2 4.84853
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.83545
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, BCL2, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.82952
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.82524
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, F10, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 4.73543
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, BCL2, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.71655
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, AKR1C3, ALOX12, ALOX15, CYP19A1, CYP3A4, DHFR, TYR 4.63375
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, F10, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 4.63082
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, AKR1C3, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DYRK1A, F10, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP2, MMP9, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 4.57883
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS, TOP1 4.57883
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, BCL2, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.57268
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PIM1, PPARA, PTGS2, TBXAS1, TYR 4.51256
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GSK3B, IDO1, MMP1, MMP2, MMP9, SRC, XDH 4.46044
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.44064
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PIM1, PPARA, PTGS2, TBXAS1, TYR 4.42101
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, DHFR, DNMT1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 4.41995
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX12, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DNMT1, DYRK1A, FABP3, FABP4, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, NR3C1, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 4.41354
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CYP1B1, F10, FLT3, KDR, KIT, MET, PTGS2, SRC, XDH 4.37134
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 4.35209
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 4.30172
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.24558
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.23981
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, KIT, MMP2, POLB, PPARA, PTGS2, SRC, TERT, TRPV1, TYR 4.23981
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AXL, CYP1B1, DNMT1, GSK3B, IGF1R, MMP2, MMP9, NR3C1, PTGS2, SRC, TRPV1 4.23928
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, F10, FLT3, GSK3B, IGF1R, KDR, KIT, MET, SRC, TNKS, TOP1 4.22754
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, GSK3B, MET, MMP9, PPARA, SRC, TERT, TNKS 4.219
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.2156
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DHFR, DNMT1, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR 4.20965
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, DHFR, IDO1, PTGS2 4.19401
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTGS2, SRC, TERT, TRPV1 4.16858
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APP, CYP1A1, CYP1B1, FLT3, NR3C1, PTGS2, SRC, TRPV1 4.15633
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 4.12439
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ALOX12, APP, CYP19A1, DHFR, DYRK1A, FABP4, GSK3B, IDO1, IGF1R, MET, MMP2, PPARA, PTGS2, PTPRS, SRC, TERT, XDH 4.12275
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, F10, FLT3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, XDH 3.96719
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APP, DNMT1, FLT3, GSK3B, IGF1R, KIT, MMP2, NR3C1, PTGS2, SRC, TRPV1 3.96283
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, GSK3B, KIT, PPARA, SRC, TOP1 3.95788
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APP, AXL, BCL2, CA12, CA2, CA7, FABP3, FABP4, FLT3, MET, POLA1, POLB, SRC, TERT, TRPV1 3.91431
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, KDR, PTGS2, SRC, TNKS, TNKS2, TRPV1 3.89428
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, POLB, PPARA, PTGS2, SRC, TERT 3.87975
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.86771
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DHFR, DNMT1, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR 3.86395
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.84703
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, IDO1, KIT, MMP2, MMP9, POLA1, POLB, PPARA, PTGS2, SRC, TERT, TRPV1 3.80588
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, BCL2, CA2, FLT3, NR3C1, PTGS2, SRC 3.80308
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DNMT1, DYRK1A, FABP3, FABP4, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, NR3C1, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 3.7985
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, FLT3, NR3C1, PTGS2, SRC 3.72788
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.6635
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.6392
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, KIT, MMP9, TERT 3.63075
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DYRK1A, GSK3B, SRC, TNKS, TOP1 3.56141
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS, TOP1 3.55481
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, ALOX12, BCL2, CSNK2A1, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTGS2, TERT 3.52018
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.51469
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, BCL2, CYP1B1, DHFR, PTGS2, TRPV1, XDH 3.50584
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, IDO1 3.50584
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 3.49978
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.48988
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.48988
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.48988
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, DNMT1, GSK3B, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 3.48988
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.47574
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, MMP9, SRC 3.44513
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, FLT3, KIT, MET, PIM1, POLA1, SRC, TYR 3.43604
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.40404
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, MMP9, PTGS2, SRC 3.38514
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BACE1, BCL2, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DHFR, DYRK1A, F10, FLT3, FUT7, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, POLB, PPARA, PTGS2, PTPRS, SRC, TNKS, TNKS2, TOP1, TYR, XDH 3.38514
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DHFR, PPARA 3.38496
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.3508
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC, TERT 3.3508
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GSK3B, IGF1R, PPARA, PTGS2, SRC, TRPV1 3.33988
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DYRK1A, GSK3B, SRC, TNKS, TOP1 3.31869
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC, TERT 3.26231
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, IDO1 3.25961
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PTGS2, SRC 3.23528
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, AKR1C3, CYP1A1, FABP3, FLT3, KIT, PPARA, PTGS2, SRC 3.22052
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.22052
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.22052
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.20458
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KDR, NR3C1, PTGS2, SRC, TRPV1 3.11118
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.09534
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 3.07626
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DYRK1A, F10, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TRPV1, TUBB3, TYR, XDH 3.03747
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, F10, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 3.03747
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, GSK3B, TNKS 3.03003
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC, TRPV1 3.01243
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGS2 3.01145
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, F10, KIT, MET, SRC, XDH 2.97644
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, GSK3B, KDR, MET, MMP9, SRC, TNKS, TNKS2 2.9752
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DNMT1, GSK3B, IGF1R, MMP2, PTGS2, SRC, TRPV1 2.96109
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, KIT, PTGS2 2.93472
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, KIT, PTGS2 2.93472
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, FABP4, GSK3B, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TNKS 2.9314
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AKR1C3, ALOX15, APP, AURKB, BCL2, CSNK2A1, DHFR, DNMT1, DYRK1A, FABP3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, NR3C1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.92318
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, KIT, PTGS2 2.92003
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, POLB, SRC 2.91345
[BP] GO:0032845 None ADORA1, BCL2, SRC, TNKS, TNKS2, TRPV1 2.89967
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.8994
[BP] GO:0016488 None AKR1B10, AKR1C3 2.89749
[BP] GO:0016487 None AKR1B10, AKR1C3 2.89749
[BP] GO:0016107 None AKR1B10, AKR1C3 2.89749
[BP] GO:0006714 None AKR1B10, AKR1C3 2.89749
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.89749
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.89749
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.89749
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, DYRK1A, GSK3B, TNKS 2.89702
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.79443
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, F10, KIT, MET, SRC 2.79324
[BP] GO:0033554 cellular response to stress AKR1B1, AKR1C3, ALOX15, AXL, BCL2, CA2, CA9, CYP1B1, DHFR, GSK3B, MMP9, POLA1, POLB, PTGS2, SRC, TERT, TRPV1 2.78972
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DNMT1, GSK3B, IGF1R, MMP2, PTGS2, SRC, TRPV1 2.73719
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.73719
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CYP1A1, PTGS2, SRC, TRPV1, TYR 2.70908
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AKR1C3, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GSK3B, IDO1, XDH 2.7014
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, POLB, TYR 2.57995
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, GSK3B, PTGS2, SRC, TERT, TRPV1 2.57469
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.57469
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AKR1C3, ALOX15, APP, AURKB, BCL2, DNMT1, DYRK1A, FABP3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, NR3C1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.55786
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1 2.54218
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.50238
[BP] GO:1904018 positive regulation of vasculature development ALOX12, CYP1B1, KDR, KIT, PTGS2, TERT 2.47733
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP2, MMP9, TRPV1 2.47389
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.47389
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.47389
[BP] GO:0016095 None AKR1B10, AKR1C3 2.47389
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.45122
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.4506
[BP] GO:0046394 None ALOX12, ALOX15, ALOX5, CYP1A1, DHFR, IDO1, PTGS2 2.43202
[BP] GO:0016053 None ALOX12, ALOX15, ALOX5, CYP1A1, DHFR, IDO1, PTGS2 2.42348
[BP] GO:0034097 response to cytokine ALOX15, AXL, BCL2, FABP4, FLT3, GSK3B, PTGS2, SRC, TRPV1 2.41043
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX12, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DYRK1A, F10, FABP3, FABP4, FLT3, GSK3B, HSD11B1, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TOP1, TRPV1, XDH 2.39918
[BP] GO:0048608 reproductive structure development AKR1C3, AXL, BCL2, CYP19A1, HSD17B2, KIT, SRC 2.39806
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, BCL2, CYP19A1, DYRK1A, GSK3B, IGF1R, MET, MMP9, PPARA, PTGS2, PTPRS, SRC, TERT, XDH 2.39663
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AKR1C3, APP, AURKB, BCL2, CSNK2A1, DHFR, DNMT1, DYRK1A, FABP4, GSK3B, IGF1R, KDR, MET, MMP9, NR3C1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.38756
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, NR3C1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.38178
[BP] GO:0043065 positive regulation of apoptotic process AKR1C3, BCL2, CYP1B1, GSK3B, IDO1, MMP9, PTGS2, SRC, TRPV1, XDH 2.36291
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.35574
[BP] GO:0006066 None AKR1B1, AKR1B10, AKR1C3, APP, CYP1B1, CYP3A4, DHFR 2.34817
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.34339
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.34339
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 2.34339
[BP] GO:0043068 positive regulation of programmed cell death AKR1C3, BCL2, CYP1B1, GSK3B, IDO1, MMP9, PTGS2, SRC, TRPV1, XDH 2.33746
[BP] GO:0034502 protein localization to chromosome AURKB, TERT, TNKS, TNKS2 2.32963
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.3025
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, TRPV1 2.29787
[BP] GO:0007584 response to nutrient AKR1C3, ALPL, CYP1A1, PTGS2, TRPV1, TYR 2.29719
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, SRC 2.29553
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A1, HSD17B2, IDO1, KIT, MMP2, MMP9, PTGS2, SRC 2.29486
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.29486
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 2.29137
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AXL, BCL2, CA2, CYP1B1, IDO1, KDR, KIT, MET, MMP9, PIM1, PTGS2, SRC, TERT, TRPV1 2.2618
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.25753
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.24182
[BP] GO:0070213 None TNKS, TNKS2 2.23207
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.23207
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.21511
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.20331
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.19774
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 2.19676
[BP] GO:0006940 None ADORA1, CHRM2, KIT, PTGS2 2.19658
[BP] GO:0031667 response to nutrient levels AKR1C3, ALPL, BCL2, CYP1A1, PTGS2, SRC, TRPV1, TYR 2.17238
[BP] GO:0080135 regulation of cellular response to stress APP, DHFR, DYRK1A, GSK3B, IGF1R, MET, PTGS2, PTPRS, TERT, XDH 2.16891
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 2.16391
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, APP, AXL, BCL2, CA2, CHRM2, CYP1B1, GSK3B, IDO1, KDR, KIT, MET, MMP9, PIM1, PTGS2, PTPRS, SRC, TERT, TNKS2, TRPV1, XDH 2.15712
[BP] GO:0010942 positive regulation of cell death AKR1C3, BCL2, CYP1B1, GSK3B, IDO1, MMP9, PTGS2, SRC, TRPV1, XDH 2.108
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.10668
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.10668
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, IGF1R, SRC, TNKS, TNKS2 2.10229
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, APP, AURKB, BCL2, CSNK2A1, DHFR, DNMT1, DYRK1A, FABP4, GSK3B, IGF1R, MET, MMP9, NR3C1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.07511
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.06567
[BP] GO:1904646 cellular response to amyloid-beta APP, GSK3B, IGF1R 2.06567
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, DHFR, FLT3 2.05786
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP2, MMP9, SRC, TNKS, TNKS2, TRPV1 2.05496
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.05496
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.05496
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.05496
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.05496
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.05496
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, NR3C1, PTGS2 2.02649
[BP] GO:0071383 None AKR1C3, FLT3, NR3C1, SRC 2.01555
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CBR1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, F10, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD11B1, HSD17B1, HSD17B2, IDO1, KDR, KIT, MMP2, MMP9, NR3C1, PIM1, POLA1, PTGS2, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TRPV1, TYR, XDH 3.75486
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, FLT3, FUT7, GSK3B, HSD11B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP2, PIM1, PTGS2, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR 2.74282
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DYRK1A, FABP3, FABP4, FLT3, FUT7, GSK3B, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 2.21247
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DYRK1A, FABP3, FABP4, FLT3, FUT7, GSK3B, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 2.07511
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, F10, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP2, PIM1, PTPRS, SRC, TERT, TRPV1 2.07491
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, FLT3, HSD11B1, HSD17B2, PTGS2, TBXAS1 2.00507
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DYRK1A, F10, FLT3, FUT7, GSK3B, HSD11B1, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTGS2, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 16.712
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DYRK1A, F10, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TRPV1, TUBB3, TYR, XDH 12.9845
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, TBXAS1, TNKS, TYR, XDH 11.3844
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.1293
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, HSD11B1, HSD17B1, HSD17B2, IDO1, PTGS2, TBXAS1, TYR, XDH 10.1128
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, F10, IDO1, KIT, MMP1, MMP2, MMP9, NR3C1, PIM1, POLA1, POLB, PPARA, PTGS2, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 6.84354
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.83711
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, XDH 6.83711
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, F10, IDO1, KIT, MMP1, MMP2, MMP9, NR3C1, PIM1, POLA1, POLB, PPARA, PTGS2, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 6.54712
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, PTGS2, SRC, TBXAS1 6.46323
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.38716
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, PTGS2, SRC, TBXAS1 6.26908
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR 6.21855
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, PPARA, SRC, TOP1, TRPV1 6.14897
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS2, TBXAS1, TYR 5.86989
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, HSD17B1, IDO1, POLA1, PTGS2, SRC, TBXAS1, XDH 5.43776
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.32733
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, CBR1, HSD11B1, HSD17B1, HSD17B2, XDH 5.1214
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.08172
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, IDO1, PTGS2 5.08172
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, IDO1, PTGS2 5.01624
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.71799
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, CBR1, HSD11B1, HSD17B1, HSD17B2 4.3774
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.32409
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 4.2775
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, POLA1, POLB, SRC, TERT, TOP1 4.2125
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.19954
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 4.16222
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.05483
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, CSNK2A1, DHFR, DNMT1, DYRK1A, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, POLA1, SRC, TOP1, TRPV1, TUBB3, XDH 3.69089
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD17B1, HSD17B2 3.48988
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, AURKB, AXL, CSNK2A1, DHFR, DYRK1A, F10, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, PTPRS, SRC, TOP1, TRPV1, TUBB3, XDH 3.42834
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 3.39404
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD17B1, HSD17B2 3.38514
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.3508
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, MMP1, MMP2, MMP9, NR3C1, PPARA, TNKS 3.26231
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DHFR, DNMT1, DYRK1A, FLT3, GSK3B, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, POLA1, SRC, TOP1, TRPV1, TUBB3, XDH 3.11704
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CSNK2A1, DHFR, DNMT1, DYRK1A, FLT3, GSK3B, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, POLA1, SRC, TOP1, TRPV1, TUBB3, XDH 3.1162
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 3.03747
[MF] GO:0045550 None AKR1B10, AKR1C3 2.89749
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.89749
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, IDO1, PTGS2 2.78402
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, XDH 2.7623
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.47389
[MF] GO:0047718 None AKR1B10, AKR1C3 2.47389
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.47389
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.47389
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.47389
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, APP, AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, POLA1, PTPRS, SRC, TOP1, TRPV1, TUBB3 2.47007
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.4506
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.23207
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.23207
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.10668
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.05496
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, F10, FABP3, FABP4, HSD17B1, NR3C1, PPARA, TRPV1 2.05496
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, TERT, TRPV1, TYR, XDH 2.02062


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 11.2595
Metabolic pathways_Homo sapiens_hsa01100 CBR1, DNMT1, ALOX15, AKR1C3, AKR1B1, ALOX12, PTGS2, TYR, CYP3A4, CYP19A1, DHFR, HSD11B1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, IDO1 10.5093
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP3A4, CYP19A1 10.8164
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.2595
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1, AKR1C3, ALOX12, PTGS2 7.3428
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 6.5569
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, FLT3, MMP1, MMP2, KIT, BCL2, PTGS2, MMP9, MET, IGF1R 4.8102
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.4547
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET 3.942
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 3.8459
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.1814
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, ALOX12, PTGS2 3.3351
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.8438
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, BCL2, MET, IGF1R 3.1814
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, GSK3B, KIT, KDR, BCL2, MET, IGF1R 2.9382
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.0141
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0784
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, MET, IGF1R 2.2755
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.212
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.027
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.2142
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.1641
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, ADORA3, ADORA1, TRPV1, NR3C1 1.9154
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.0809
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.1019
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8265
Prostate cancer_Homo sapiens_hsa05215 GSK3B, BCL2, IGF1R 1.8193
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.7406
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, CYP3A4 2.027
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.9987
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 1.7399
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.7406
Melanogenesis_Homo sapiens_hsa04916 GSK3B, KIT, TYR 1.7404
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.6486
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.7791
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 1.604
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.4051
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.3858
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.5869
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, GSK3B, APP 1.252
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, BCL2 1.1037
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, ADORA1, PPARA 1.1124
HTLV-I infection_Homo sapiens_hsa05166 POLB, GSK3B, TERT 0.9059
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.1835
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC 1.1805
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC 1.0739
Insulin resistance_Homo sapiens_hsa04931 GSK3B, PPARA 0.9278
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.9278
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.9646
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, BCL2 1.2588
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0546
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2013
Small cell lung cancer_Homo sapiens_hsa05222 BCL2, PTGS2 1.0739
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1242
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.1981
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2903
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3 1.0739
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.8874
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, SRC 0.9003
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, BCL2 0.8938
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0739
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9003
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9003
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1 0.8297
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA 0.8404
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, IGF1R 0.8176
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1 0.8176
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.8693
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8193
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PPARA 0.7862
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.7693
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.7693
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.7423
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7222
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.719
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.644
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.6889
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC 0.6326
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3288
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3481
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2 0.3343
Influenza A_Homo sapiens_hsa05164 GSK3B 0.3401
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.3753
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3822
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3944
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3753
Insulin signaling pathway_Homo sapiens_hsa04910 GSK3B 0.3944
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.3881
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.4678
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4053
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4229
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4229
Cell cycle_Homo sapiens_hsa04110 GSK3B 0.4229
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B 0.4125
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.4828
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4789
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.4717
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7406
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4872
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4717
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4869
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4789
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4868
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4955
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4959
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4968
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4963
Peroxisome_Homo sapiens_hsa04146 XDH 0.5148
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.5519
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5296
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5519
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5507
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.56
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5787
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5805
Glioma_Homo sapiens_hsa05214 IGF1R 0.5805
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5805
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5952
Shigellosis_Homo sapiens_hsa05131 SRC 0.5805
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8914
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6432
Endometrial cancer_Homo sapiens_hsa05213 GSK3B 0.6343
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7215
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.6251
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6251
Malaria_Homo sapiens_hsa05144 MET 0.644
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6375
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.6409
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6737
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6694
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7423
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7693
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7423
DNA replication_Homo sapiens_hsa03030 POLA1 0.7359
Base excision repair_Homo sapiens_hsa03410 POLB 0.7513
Folate biosynthesis_Homo sapiens_hsa00790 DHFR, ALPL 2.2115
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8176
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8074
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.8864
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0141


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)