TCM Prescription: Fu Fang Ling Zhi Infusion



Prescription Description
Prescription IDTCMF3677
Pinyin NameFu Fang Ling Zhi Chong Ji
Chinese Name复方灵芝冲剂
English NameFu Fang Ling Zhi Infusion
Function Description黄疸
IndicationsJaundice disorder, Jaundice
Disease ICD-11 Category SA01 [Jaundice disorder (TM1), 黄疸 (TM1) ];
ME10.1 [Unspecified jaundice, 未特指的黄疸 ];
Human Tissues Associated with IndicationLiver
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1299 Ganoderma lucidum 灵芝 TCMH1299 MGEN736-15
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1351 Nocardia sp.
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MET, PPARA, PTGES, TRPV1 10.472
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, GLO1, HSD17B3, PIM1, PPARA, PTGES, TYR, XDH 8.71215
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, CYP3A4, F10, F3, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, HSD17B3, KDR, MAOA, MET, PPARA, SRC, TRPV1, XDH 8.22434
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, NR3C1, PIM1, PPARA, PTGES, PTPN1, RELA, SRC, TOP1, TOP2A, TRPV1, TYR, XDH 8.06012
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, HSD17B3 7.77248
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GLO1, IGF1R, KDR, MAP2K1, MET, PIM1, PPARA, PTPN1, RELA, SRC, TOP2A, TRPV1, XDH 7.58705
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GLO1, IGF1R, KDR, MAP2K1, MET, PIM1, PTPN1, RELA, SRC, TOP2A, TRPV1, XDH 7.40667
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7 7.05016
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, PTGES, RELA, SRC 7.03744
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 7.03744
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GLO1, IGF1R, KDR, MAP2K1, PIM1, PTPN1, RELA, SRC, TOP2A, TRPV1, XDH 6.75806
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, HSD17B3 6.66615
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CYP1B1, F10, F3, FLT3, KDR, MAP2K1, MAP3K7, MET, PTPN1, RELA, SRC, XDH 6.5244
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, NR3C1, PIM1, PPARA, PTGES, PTPN1, RELA, SRC, TOP1, TOP2A, TYR, XDH 6.5085
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, HSD17B3 6.23941
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, KDR, MAP2K1, MAP3K7, MET, PTPN1, RELA, SRC, XDH 6.15988
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, APEX1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, NR3C1, PPARA, PTGES, RELA, SRC, TRPV1, TYR 6.15988
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, KDR, MAP2K1, MAP3K7, MET, PTPN1, RELA, SRC, XDH 6.15988
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, MAP2K1, PPARA, RELA, SRC, TYR 6.15988
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7 6.08461
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2, HSD17B3 6.07665
[BP] GO:0014070 response to organic cyclic compound APEX1, APP, AR, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, NR3C1, PTGES, RELA, SRC, TRPV1, TYR 5.74803
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, HSD17B2, IGF1R, NR3C1, PPARA, PTGES, RELA, SRC, TRPV1, TYR 5.69945
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B3, MAOA, TYR 5.69945
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, HSD17B3, PTGES 5.34178
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.25865
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, APEX1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, NR3C1, PPARA, PTGES, RELA, SRC, TOP1, TRPV1, TYR 5.18314
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, RELA, SRC 5.16156
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGES 5.16156
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, MET, PPARA, PTGES 5.10551
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES 5.09763
[BP] GO:0033993 response to lipid AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, NR3C1, PTGES, RELA, SRC, TYR 4.9996
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES 4.90596
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, APP, AR, CDC25B, CSNK2A1, CYP1B1, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, PIM1, PTGES, RELA, SRC, XDH 4.90574
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, PIM1, PTPN1, RELA, SRC 4.89208
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, F10, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PTPN1, RELA, SRC, XDH 4.89208
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, HSD17B3 4.88699
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, F10, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, NR3C1, PIM1, PPARA, PTPN1, RELA, SRC, TOP2A, TRPV1, XDH 4.88075
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APEX1, APP, AR, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MAP2K1, MET, PPARA, PTPN1, SRC, TRPV1 4.78808
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CSNK2A1, CYP1B1, F10, F3, FLT3, KDR, MAP2K1, MAP3K7, MET, PTPN1, RELA, SRC, XDH 4.73747
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA2, CA6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, F10, F3, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MAP2K1, MAP3K7, NR3C1, PPARA, PTGES, PTPN1, RELA, SRC, TOP1, TOP2A, TRPV1, TYR 4.67375
[BP] GO:0009725 response to hormone AKR1B1, APEX1, AR, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, NR3C1, PPARA, RELA, SRC, TRPV1 4.63226
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAP2K1, MAP3K7, MET, NR3C1, PIM1, PPARA, PTGES, PTPN1, RELA, SRC, TOP1, TOP2A, TRPV1, TYR, XDH 4.52903
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, NR3C1, PIM1, PPARA, PTGES, PTPN1, RELA, SRC, TOP1, TOP2A, TRPV1, TYR, XDH 4.5102
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, HSD17B3 4.45375
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, APP, AR, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, IGF1R, NR3C1, PPARA, RELA, SRC, TRPV1 4.30473
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KDR, NR3C1, RELA, SRC, TRPV1 4.28226
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, PIM1, PTPN1, RELA, SRC 4.24676
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGES 4.13644
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, F10, F3, FABP3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, NR3C1, PIM1, PPARA, PTPN1, RELA, SRC, TOP2A, TRPV1, XDH 4.11036
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA2, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, HSD17B3, KDR, MAP2K1, MET, PIM1, PPARA, RELA, SRC, TOP2A, TYR 4.10999
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APEX1, APP, CACNA1C, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, SRC 4.04977
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, AR, FLT3, KDR, MAP2K1, MAP3K7, PTPN1, SRC, XDH 4.04927
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APEX1, APP, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, SRC 3.96666
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, APEX1, APP, AR, AXL, CYP1A1, CYP1B1, FABP4, FLT3, IGF1R, KDR, NR3C1, RELA, SRC, TRPV1 3.96666
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES 3.94755
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, FABP3, PPARA, TRPV1 3.93336
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.86112
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 3.86112
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, HSD17B3, TYR 3.84979
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGES 3.84979
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.71507
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APEX1, APP, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, SRC 3.71054
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, NR3C1, PTPN1, RELA, SRC, TOP2A, TRPV1 3.68631
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, RELA, SRC 3.67767
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, RELA, SRC 3.67767
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, PPARA, RELA, SRC, TRPV1 3.65957
[BP] GO:0030522 intracellular receptor signaling pathway AR, MAP3K7, NR3C1, PIM1, PPARA, RELA, SRC 3.65957
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, APP, AR, CYP1A1, CYP1B1, FLT3, NR3C1, SRC, TRPV1 3.64434
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, APEX1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, NR3C1, RELA, SRC, TRPV1 3.61351
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, RELA 3.60084
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, AR, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, PTPN1, SRC, XDH 3.56722
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PTPN1, RELA, SRC, XDH 3.5543
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.52355
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.52351
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PPARA, PTGES 3.51289
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.49853
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, FABP3, KDR, NR3C1, RELA, SRC, TOP1, TRPV1 3.49392
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, F10, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, SRC, TOP1, TOP2A 3.49383
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, RELA 3.49383
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PTPN1, RELA, SRC, XDH 3.49373
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APEX1, APP, AXL, CA12, CA2, CA7, CACNA1C, FABP3, FABP4, FLT3, MET, SRC, TRPV1 3.48773
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APEX1, APP, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, SRC 3.44209
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, MAP2K1, PIM1, PPARA, RELA, SRC, TYR 3.4293
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.4293
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AR, AXL, CACNA1C, CYP19A1, CYP1A2, CYP1B1, F10, F3, FABP4, HSD17B2, IGF1R, MET, PIM1, PPARA, RELA, SRC, TOP1, TRPV1, TYR 3.42474
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HSD17B3 3.42474
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PTPN1, SRC, TOP1, XDH 3.35053
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CSNK2A1, CYP1B1, F10, F3, FABP4, FLT3, KDR, MAP2K1, MAP3K7, MET, PTPN1, RELA, SRC, XDH 3.30807
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, CACNA1C, KDR, SRC, TRPV1 3.28408
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.26591
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, GLO1, IGF1R, KDR, MAP2K1, MET, NR3C1, PIM1, PPARA, PTGES, PTPN1, RELA, SRC, TOP2A, TRPV1, XDH 3.20318
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGES 3.11032
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, FABP3, PPARA, TRPV1 3.10821
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PTPN1, SRC, TOP1, XDH 3.09036
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, HSD17B3, PTGES 3.00658
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 3.00658
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.929
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGES, TYR 2.90871
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.86068
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.86068
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.86068
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CYP1B1, IGF1R, NR3C1, RELA, SRC, TRPV1 2.70846
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, RELA, SRC 2.69147
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, GLO1, IGF1R, KDR, MAP2K1, MET, NR3C1, PIM1, PPARA, PTGES, PTPN1, RELA, SRC, TOP2A, TRPV1, XDH 2.68301
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.68301
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, FABP3, FLT3, IGF1R, PPARA, RELA, SRC, TRPV1, TYR 2.68301
[BP] GO:1901654 None AKR1B1, AR, CSNK2A1, NR3C1, RELA, SRC 2.64729
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, HSD17B2, HSD17B3, MAP2K1, SRC 2.63712
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.60199
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, CDC25B, FABP3, FLT3, KDR, MAP2K1, MAP3K7, PTPN1, SRC, XDH 2.57527
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, CDC25B, FABP3, FLT3, KDR, MAP2K1, MAP3K7, PTPN1, SRC, XDH 2.57527
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, APP, CYP19A1, F3, FABP4, IGF1R, MAP2K1, MAP3K7, MET, PPARA, PTPN1, RELA, SRC, XDH 2.55517
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, NR3C1, PPARA, PTPN1, RELA, SRC, TOP2A, TRPV1, XDH 2.55269
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, CDC25B, FLT3, KDR, MAP2K1, MAP3K7, PTPN1, SRC, XDH 2.5451
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGES, TYR 2.53883
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, FLT3, MAP2K1, MET, PIM1, SRC, TYR 2.50555
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, F10, F3, FLT3, FUT7, GLO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, PIM1, PPARA, PTPN1, RELA, SRC, TOP1, TOP2A, TYR, XDH 2.49666
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGES, TYR 2.471
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, RELA, SRC 2.46982
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, KDR, RELA, SRC 2.46519
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.45838
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, AR, CDC25B, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, PPARA, PTPN1, SRC, XDH 2.44872
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, TRPV1 2.44574
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, FABP3, FLT3, IGF1R, PPARA, RELA, SRC, TRPV1, TYR 2.43648
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.426
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, AR, CDC25B, FLT3, KDR, MAP2K1, MAP3K7, PTPN1, SRC, XDH 2.40298
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, AR, FLT3, IGF1R, NR3C1, RELA, SRC, TRPV1 2.38976
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.38812
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AR, AXL, CA2, CYP1B1, F3, KDR, MAP2K1, MAP3K7, MET, PIM1, RELA, SRC, TRPV1 2.3715
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AR, AURKB, CDC25B, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, NR3C1, PPARA, PTPN1, RELA, SRC, TOP2A, TRPV1, XDH 2.35434
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, PPARA, PTPN1, SRC, XDH 2.35298
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.35298
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, IGF1R, RELA, SRC 2.35114
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F10, F3, MET, SRC, XDH 2.32117
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, PPARA, PTPN1, SRC, XDH 2.32031
[BP] GO:0006081 None AKR1B10, CYP1B1, GLO1, RELA 2.29116
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.28974
[BP] GO:0046683 response to organophosphorus APEX1, APP, RELA, TRPV1, TYR 2.28806
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.28781
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, CDC25B, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, PTPN1, SRC, XDH 2.28781
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.28082
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, FABP4, PTGES 2.27976
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, PTGES, RELA, SRC 2.25634
[BP] GO:0048545 response to steroid hormone AR, CA2, FLT3, NR3C1, RELA, SRC 2.25431
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, F10, F3, IGF1R, KDR, MET, SRC 2.25331
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.25331
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.23693
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.23693
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, NR3C1, PPARA, PTPN1, RELA, SRC, TOP2A, TRPV1, XDH 2.21517
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, AR, CDC25B, CSNK2A1, F3, FLT3, IGF1R, KDR, PIM1, RELA 2.21517
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.17202
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, F10, F3, IGF1R, KDR, MET, SRC 2.17202
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, AR, CDC25B, CSNK2A1, F3, FLT3, KDR, MAP2K1, MAP3K7, PTPN1, RELA, SRC, XDH 2.17202
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, IGF1R, MAP2K1, MAP3K7, PTPN1, SRC 2.14461
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, MAOA, SRC, XDH 2.13787
[BP] GO:0071383 None AR, FLT3, NR3C1, SRC 2.12903
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CYP1B1, RELA, SRC 2.12896
[BP] GO:0014074 response to purine-containing compound APEX1, APP, RELA, TRPV1, TYR 2.107
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, MAP2K1, MAP3K7, PPARA, PTGES, PTPN1, RELA, SRC, TOP2A, TRPV1 2.10545
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, F10, F3, IGF1R, KDR, MET, SRC 2.10545
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, HSD17B3 2.09453
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CACNA1C, KDR, SRC, TRPV1 2.0839
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, MAP2K1, RELA, TYR 2.06941
[BP] GO:0034097 response to cytokine ALOX15, AXL, FABP4, FLT3, PTGES, RELA, SRC, TRPV1 2.06925
[BP] GO:0061370 testosterone biosynthetic process CYP19A1, HSD17B3 2.06925
[BP] GO:0010641 None F3, SRC 2.06925
[BP] GO:0007598 None F10, F3 2.06925
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.06925
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.06925
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, PTGES 2.06769
[BP] GO:0071363 cellular response to growth factor stimulus APP, KDR, NR3C1, RELA, SRC, TRPV1 2.06136
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, F3, MET, SRC 2.05764
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, PTGES 2.03789
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, F10, F3, IGF1R, KDR, MET, SRC 2.03525
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, CA12, CA2, CA7, CACNA1C, FABP3, FABP4, MET, TRPV1 2.02626
[BP] GO:1901655 None AKR1B1, AR, NR3C1, SRC 2.02429
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, F3, FABP4, KDR, MAP2K1, MET, PPARA, RELA 2.02371
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, F3, FABP3, FABP4, FLT3, GLO1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, NR3C1, PIM1, PPARA, PTGES, PTPN1, RELA, SRC, TOP1, TOP2A, TRPV1, XDH 2.02371
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.00568
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, IGF1R, MAP2K1, MAP3K7, PTPN1, SRC 2.00325
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, APP, AR, AURKB, CA1, CA2, CA4, CA7, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, KDR, MAOA, MAP2K1, MAP3K7, NR3C1, PIM1, PTGES, PTPN1, RELA, SRC, TOP1, TOP2A, TRPV1, TYR, XDH 4.4265
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.51301
[CC] GO:0009330 None TOP1, TOP2A 2.86068
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, APP, AR, AXL, CA12, CA14, CA2, CA4, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, F3, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, PIM1, PTGES, PTPN1, SRC, TRPV1, TYR 2.75388
[CC] GO:0031233 None CA4, F10, F3 2.43899
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AR, AXL, CA12, CA14, CA2, CA4, CACNA1C, CSNK2A1, F10, F3, FLT3, GLO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PTPN1, SRC, TRPV1 2.17964
[CC] GO:0044432 endoplasmic reticulum part APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, FLT3, HSD11B1, HSD17B2, HSD17B3, PTGES, PTPN1 2.04654
[CC] GO:0005783 None ADORA1, APEX1, APP, CA4, CYP19A1, FLT3, HSD17B3, KDR, MAP2K1, PTPN1, XDH 2.03525
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, F3, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, PIM1, PTGES, PTPN1, SRC, TOP1, TOP2A, TYR, XDH 10.4637
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7 10.217
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MAP2K1, MAP3K7, MET, NR3C1, PIM1, PPARA, PTGES, PTPN1, RELA, SRC, TOP1, TOP2A, TRPV1, TYR, XDH 10.217
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GLO1, NR3C1, PIM1, PPARA, PTPN1, TYR, XDH 10.217
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 8.22434
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7 7.04673
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7 6.5244
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 6.07665
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, GLO1 5.6028
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.37356
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PPARA, SRC, TOP1, TOP2A, TRPV1 5.18314
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.16156
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, GLO1, MAP3K7, NR3C1, PIM1, PPARA, PTPN1, TOP2A, TRPV1, TYR, XDH 4.88075
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, GLO1, MAP3K7, NR3C1, PIM1, PPARA, PTPN1, TOP2A, TRPV1, TYR, XDH 4.52682
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, CYP3A4, F10, F3, FABP3, FABP4, HSD17B1, NR3C1, PPARA, SHBG, TRPV1 4.52682
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, HSD17B3, XDH 4.25415
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NR3C1, SHBG 4.17067
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.13644
[MF] GO:0043168 anion binding ALOX15, APP, AURKB, AXL, CSNK2A1, F10, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PTGES, RELA, SRC, TOP1, TOP2A, TRPV1, XDH 3.98469
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.94755
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 3.91681
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.58024
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.57456
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2, HSD17B3 3.56257
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, HSD17B3 3.49856
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2, HSD17B3 3.48773
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.39798
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.36899
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 3.26591
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.20318
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.16869
[MF] GO:0005496 steroid binding AR, CYP3A4, HSD17B1, NR3C1, SHBG 3.00658
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 2.94062
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 2.91571
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.86068
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, PTGES, SRC, XDH 2.70974
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA6, CA7, GLO1, NR3C1, PPARA, PTPN1 2.46437
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.45838
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.45838
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.45838
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, PIM1, PPARA, PTPN1, RELA, SRC 2.40907
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 2.3294
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.23693
[MF] GO:0005497 None AR, SHBG 2.23693
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.23693
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1, TOP2A, TRPV1, XDH 2.22954
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.17202
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.13059
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.06925
[MF] GO:0016853 None ALOX12, ALOX15, PTGES, TOP1, TOP2A 2.06547
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1, TOP2A, TRPV1 2.06159
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.00568


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP3A4, CYP19A1 11.2221
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA14 11.4269
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.2255
Metabolic pathways_Homo sapiens_hsa01100 MAOA, ALOX15, HSD17B3, AKR1B1, ALOX12, TYR, CYP3A4, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH, PTGES 6.5556
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOA, ALOX5, ALOX15, ALOX12, CACNA1C 5.9481
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 5.6975
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.2783
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 4.0031
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.0856
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, PIM1, RELA 3.4291
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12, PTGES 3.3253
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, RELA, IGF1R 2.8142
cAMP signaling pathway_Homo sapiens_hsa04024 MAP2K1, ADORA1, CACNA1C, PPARA, RELA 2.528
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, KDR, MET, IGF1R 2.528
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, SRC, KDR, MET, IGF1R 2.528
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, KDR, MET, IGF1R 2.4757
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, KDR, MET, RELA, IGF1R 2.3765
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 2.2023
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, ADORA1, RELA 2.4488
Pathways in cancer_Homo sapiens_hsa05200 AR, MAP2K1, FLT3, MET, RELA, IGF1R 2.2023
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.9788
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR 2.2334
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, ADORA1, CACNA1C 2.1249
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, MET 2.2023
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, PIM1, CYP1B1, MET, CDC25B 2.0592
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.2023
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.2023
Melanoma_Homo sapiens_hsa05218 MAP2K1, MET, IGF1R 2.1816
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, SRC, RELA 2.1787
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2, CYP3A4 2.2023
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, RELA, IGF1R 2.0328
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MAP2K1, KDR, MET, RELA, IGF1R 1.8851
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, CACNA1C 1.9535
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.8979
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.2023
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIM1, F3, RELA 1.8831
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, CDC25B, IGF1R 1.8979
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, MAP3K7, RELA 1.9389
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, RELA, IGF1R 1.8788
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.8655
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.8788
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, CACNA1C 1.8471
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MAP3K7, RELA 1.8489
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA, RELA 1.8508
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.6914
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, MAP3K7, RELA 1.7983
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.7575
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.6914
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, TRPV1, NR3C1 1.6137
Measles_Homo sapiens_hsa05162 CSNK2A1, MAP3K7, RELA 1.6692
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, SRC, RELA 1.6084
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C 1.5291
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.4241
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, SRC, RELA 1.4177
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, MAP3K7, RELA 1.3691
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1148
HTLV-I infection_Homo sapiens_hsa05166 RELA 0.2761
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, RELA 1.0721
Apoptosis_Homo sapiens_hsa04210 MAP2K1, RELA 0.9893
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, SRC 1.0757
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, IGF1R 1.0154
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1 0.9905
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC 1.1992
Glioma_Homo sapiens_hsa05214 MAP2K1, IGF1R 1.434
AMPK signaling pathway_Homo sapiens_hsa04152 MAP3K7, IGF1R 1.0559
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9905
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 1.1962
Hepatitis C_Homo sapiens_hsa05160 PPARA, RELA 1.0154
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C 1.0299
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, IGF1R 0.9872
Purine metabolism_Homo sapiens_hsa00230 XDH 0.391
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 1.0721
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA, RELA 0.9488
Calcium signaling pathway_Homo sapiens_hsa04020 CACNA1C 0.3862
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, MAP3K7 0.9872
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.511
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 RELA, IGF1R 1.2355
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, SRC 1.2833
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, SRC 0.7523
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.434
Viral carcinogenesis_Homo sapiens_hsa05203 SRC, RELA 0.7791
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4249
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.8901
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.4743
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.434
Influenza A_Homo sapiens_hsa05164 MAP2K1, RELA 0.871
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, RELA 1.434
Tuberculosis_Homo sapiens_hsa05152 SRC, RELA 0.8623
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.862
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 CACNA1C 0.4448
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1 0.4517
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, RELA 1.4033
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.434
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, RELA 1.4033
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.2833
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.4719
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.4278
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC 1.2833
Platelet activation_Homo sapiens_hsa04611 SRC 0.5
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4969
Axon guidance_Homo sapiens_hsa04360 MET 0.4909
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.4153
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4816
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.434
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3601
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.5033
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.522
Leishmaniasis_Homo sapiens_hsa05140 MAP3K7, RELA 1.4033
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 RELA 0.5532
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.4094
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1 0.5613
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5613
Amoebiasis_Homo sapiens_hsa05146 RELA 0.5613
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.3551
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.4153
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.5722
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5699
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.569
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.5699
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.5613
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5774
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5812
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.5913
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.5787
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5869
Salmonella infection_Homo sapiens_hsa05132 RELA 0.5869
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5799
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5913
Small cell lung cancer_Homo sapiens_hsa05222 RELA 0.5869
Peroxisome_Homo sapiens_hsa04146 XDH 0.5913
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC 1.7047
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.6084
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5913
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.6026
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6165
Pertussis_Homo sapiens_hsa05133 RELA 0.6146
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8788
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.6432
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.6165
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.639
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6603
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.6603
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1 0.6661
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RELA 0.6576
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.008
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.8049
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1 0.7033
Legionellosis_Homo sapiens_hsa05134 RELA 0.7071
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8508
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1 0.7261
Malaria_Homo sapiens_hsa05144 MET 0.743
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.7385
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7983
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.7479
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.8114
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.8589
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.8114
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.9097
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9788
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8901
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.9355
Base excision repair_Homo sapiens_hsa03410 APEX1 0.871
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9431
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9355
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.9686
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 1.0701


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)