TCM Prescription: Xiao Er Gan Yan Granules



Prescription Description
Prescription IDTCMF242
Pinyin NameXiao Er Gan Yan Ke Li 
Chinese Name小儿肝炎颗粒
English NameXiao Er Gan Yan Granules
Function Description胁痛, 黄疸
IndicationsHypochondrium pain disorder, Jaundice disorder, Jaundice
Disease ICD-11 Category SA00 [Hypochondrium pain disorder (TM1), 胁痛 (TM1) ];
SA01 [Jaundice disorder (TM1), 黄疸 (TM1) ];
ME10.1 [Unspecified jaundice, 未特指的黄疸 ];
Human Tissues Associated with IndicationHeart, Lung,Liver
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH351 Sojae semen germinatum 大豆黄卷 TCMH351
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH2119 Tetrapanax papyriferus 通草 TCMH2119
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, KIT, MMP9, PTGES, RELA, SRC, TERT 11.041
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD2, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, HSD17B3, KIT, MET, PPARA, PTGES 10.0428
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 9.69609
[BP] GO:0023056 positive regulation of signaling AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 9.69609
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PPARA, PTGES, RELA, RORC, SRC, TYR 9.69418
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A6, TYR 9.48926
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, KIT, MMP2, PPARA, PTGES, RELA, RORC, SRC, TYR 9.44278
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, KIT, MMP2, MMP9, PPARA, PTGES, RELA, RORC, SRC, TERT, TYR 9.364
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TERT, TNKS, TNKS2, TYR, XDH 9.25815
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TERT, TNKS, TNKS2, TYR, XDH 9.08753
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, HSD17B1, HSD17B2, HSD17B3 8.27583
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FLT3, PTGES, RELA, RORC, SRC, TYR 8.13297
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, F3, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HSD17B3, KDR, KIT, MAOA, MET, PPARA, SRC, TERT, TNKS, TNKS2, XDH 7.9823
[BP] GO:0032502 developmental process ACHE, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CBR1, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, FABP4, FLT3, FUT7, HSD17B2, HSD17B3, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PIM1, PPARA, PTPRS, RELA, RORC, SRC, TERT, TNKS2, TYR 7.9823
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FUT7, HSD17B3, PIM1, PPARA, PTGES, TYR, XDH 7.95004
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, HSD17B3, MAOA, TYR 7.81101
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGES 7.78213
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 7.55717
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AR, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, PTGES, RELA, RORC, SRC, TYR 7.34754
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, PTPRS, RELA, SRC, TERT, TNKS, TNKS2, XDH 7.29097
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGES 7.28838
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, HSD17B3, KDR, KIT, MAP2K1, PPARA, PTPRS, RELA, SRC, TYR 7.24665
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, PTPRS, RELA, SRC, TERT, TNKS, TNKS2, XDH 7.18633
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, KIT, MMP9, PTGES, TERT 7.18444
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD2, FABP3, FABP4, FUT7, KIT, MET, PPARA, PTGES 7.18444
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CYP1B1, DRD2, F3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MET, PTPN1, RELA, SRC, XDH 7.10365
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGES 7.10323
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, RELA, RORC, SRC, TERT 7.08896
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, DRD1, FABP3, FLT3, IGF1R, KIT, MMP2, PPARA, RELA, SRC 7.08896
[BP] GO:0042127 regulation of cell proliferation AKR1B1, AKR1C3, APP, AR, BCL2, CDC25B, CSNK2A1, CYP1B1, DNMT1, DRD2, F3, FABP3, FLT3, IGF1R, KDR, KIT, MAP2K1, MMP2, MMP9, PIM1, PTGES, RELA, SRC, TERT, XDH 7.04962
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2, HSD17B3 7.00586
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.95756
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, FLT3, HSD17B2, HSD17B3, KDR, KIT, MAP2K1, MMP9, PIM1, PPARA, PTPRS, RELA, RORC, SRC, TYR 6.67484
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, DRD1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, RELA, RORC, SRC 6.36605
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 6.32719
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2, HSD17B3 6.26981
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP2, MMP9, PTPN1, RELA, RORC, SRC, TERT 6.18512
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DYRK1A, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, XDH 6.18512
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 6.12304
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD17B1, HSD17B2, HSD17B3 6.044
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F3, FABP4, FLT3, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 6.03214
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGES 5.97122
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TERT, TNKS, TNKS2, TYR, XDH 5.95199
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.92047
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS 5.89472
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TERT, TNKS, TNKS2, TYR, XDH 5.86375
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 5.82913
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGES 5.81215
[BP] GO:0010941 regulation of cell death AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIM1, PPARA, PTPN1, RELA, SRC, TERT, XDH 5.70561
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, XDH 5.64524
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIM1, PTPN1, RELA, SRC, TERT, XDH 5.58502
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PPARA, PTGES 5.58441
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, KIT, PPARA, RELA, SRC 5.52586
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, AR, BCL2, CDC25B, CSNK2A1, DRD2, F3, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, RELA, TERT 5.49585
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, XDH 5.295
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 5.20161
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 5.14751
[BP] GO:0060548 negative regulation of cell death AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, RELA, SRC, TERT 5.06902
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC 5.02883
[BP] GO:0050896 response to stimulus ABCB1, ACHE, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, F3, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP2, MMP9, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TERT, TYR 4.95969
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD1, DRD2, MAOA 4.94988
[BP] GO:0048608 reproductive structure development AKR1C3, AR, AXL, BCL2, CYP19A1, HSD17B2, HSD17B3, KIT, MAP2K1, SRC 4.94987
[BP] GO:0031325 positive regulation of cellular metabolic process AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CDC25B, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.93547
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, F3, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, PPARA, PTPN1, PTPRS, RELA, SRC, TERT, TNKS, TNKS2, XDH 4.88294
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, F3, FABP4, HSD17B2, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RELA, RORC, SRC, TNKS2, TYR 4.86772
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, RELA, SRC, TERT 4.85794
[BP] GO:0009893 positive regulation of metabolic process AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.78525
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.7148
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS 4.69679
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DRD2, DYRK1A, F3, FLT3, FUT7, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RELA, SRC, TNKS, TNKS2, TYR, XDH 4.69228
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, DNMT1, DRD2, IGF1R, KDR, KIT, MAP2K1, MET, MMP1, MMP9, SRC, TNKS, TNKS2 4.60501
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, RELA, SRC 4.55989
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, KDR, RELA, SRC 4.39297
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.38983
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, IGF1R, KDR, MAP2K1, MMP9, PIM1, PTPN1, RELA, SRC, TERT, XDH 4.38551
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.35817
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 4.35817
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, DNMT1, FABP3, HSD17B2, KDR, MMP2, PTGES, RELA, SRC 4.33652
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, AKR1C3, CACNA1C, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, HSD17B1, HSD17B2, HSD17B3 4.31173
[BP] GO:0009966 regulation of signal transduction AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DYRK1A, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, PTPRS, RELA, SRC, TERT, TNKS, TNKS2, XDH 4.30438
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, APP, AR, DRD2, FLT3, KDR, KIT, MAP2K1, MAP3K7, PTPN1, SRC, XDH 4.30438
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 4.30438
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 4.30438
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 4.27682
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, AKR1C3, CSNK2A1, DRD1, DRD2, MAOA 4.24754
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD17B1, HSD17B2, HSD17B3 4.17179
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, MAOA, TYR 4.14836
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AR, AXL, CYP1B1, DNMT1, DRD1, IGF1R, MMP2, MMP9, RELA, RORC, SRC 4.13731
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, SRC, TNKS 4.12799
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1, HSD17B3 4.07374
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.07207
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APP, AR, CYP1A1, CYP1B1, DRD1, FLT3, RORC, SRC 4.06233
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, BCL2, CYP1A1, FLT3, KIT, MAP2K1, MET, PIM1, SRC, TYR 4.05565
[BP] GO:0051270 regulation of cellular component movement APP, BCL2, CACNA1C, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.05139
[BP] GO:0030334 regulation of cell migration APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.04547
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PPARA, PTPN1, SRC, TERT 4.01629
[BP] GO:0031399 regulation of protein modification process ALOX15, APP, AR, BCL2, CDC25B, DNMT1, DRD1, DRD2, DYRK1A, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, RELA, SRC, XDH 4.01629
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD17B1, HSD17B2, HSD17B3, PTGES 4.01522
[BP] GO:0080134 regulation of response to stress ABCB1, APP, CYP19A1, DRD2, DYRK1A, F3, FABP4, IGF1R, MAP2K1, MAP3K7, MET, MMP2, PPARA, PTPN1, PTPRS, RELA, SRC, TERT, XDH 4.00766
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DNMT1, DRD2, DYRK1A, F3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, RELA, SRC, XDH 3.99763
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.96696
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.93714
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DYRK1A, KIT, PPARA, RORC, SRC 3.89937
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, KDR, SRC 3.89624
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.86112
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, DRD2, F3, KIT, MET, SRC, XDH 3.85599
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A6 3.85547
[BP] GO:0042325 regulation of phosphorylation ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PPARA, PTPN1, SRC, XDH 3.85547
[BP] GO:0031401 positive regulation of protein modification process ALOX15, APP, AR, BCL2, CDC25B, DNMT1, DRD2, DYRK1A, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 3.85547
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, HSD17B2, HSD17B3, KIT, MAP2K1, MMP2, MMP9, SRC 3.85053
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, KDR, SRC, TNKS, TNKS2 3.84791
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AKR1C3, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, MAOA, MMP1, MMP2, MMP9, SRC, XDH 3.83054
[BP] GO:0032787 None AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PPARA, PTGES 3.82168
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, APP, AR, BCL2, CDC25B, DRD2, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 3.8177
[BP] GO:2000145 regulation of cell motility APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.79533
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, AR, BCL2, CA2, FLT3, RELA, SRC 3.77239
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 3.76992
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.76312
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.76096
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, HSD17B2, HSD17B3, KIT, MAP2K1, SRC 3.72718
[BP] GO:0043408 regulation of MAPK cascade ALOX15, APP, AR, DRD2, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, PTPN1, SRC, XDH 3.7071
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.65882
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MMP9, PIM1, PTPN1, RELA, SRC, TERT 3.62404
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, KIT, MMP9, TERT 3.61965
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, APP, AR, BCL2, CDC25B, DRD2, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 3.61034
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PPARA, PTPN1, SRC, XDH 3.60928
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, KDR, RELA, SRC 3.60518
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, AKR1C3, ALOX15, CYP19A1, CYP3A4, HSD17B3, TYR 3.60019
[BP] GO:0044093 positive regulation of molecular function ABCB1, APP, AR, AURKB, BCL2, CDC25B, DRD2, F3, FLT3, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, XDH 3.59061
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PPARA, PTPN1, SRC, XDH 3.56642
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, KIT, MMP2, PPARA, RELA, SRC, TERT, TYR 3.55177
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, APP, AR, AXL, BCL2, CBR1, CDC25B, CYP1A1, DRD1, DRD2, FABP4, FLT3, FUT7, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PTPRS, RORC, SRC, TERT 3.55167
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.51099
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, RELA, SRC 3.49716
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.49716
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.49716
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.49716
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DNMT1, DRD1, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, RELA, SRC, TYR 3.48051
[BP] GO:0040012 regulation of locomotion APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.46667
[BP] GO:0030522 intracellular receptor signaling pathway AR, MAP3K7, PIM1, PPARA, RELA, RORC, SRC 3.41724
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 3.36838
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 3.35741
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS 3.35741
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.35267
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, HSD17B3 3.24527
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APP, AR, DNMT1, DRD1, FLT3, IGF1R, KIT, MMP2, RELA, SRC 3.23455
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, APP, AR, BCL2, CDC25B, DNMT1, DRD2, DYRK1A, F3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 3.23209
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CYP1B1, DRD2, F3, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIM1, RELA, SRC, TERT 3.22275
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.22275
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.22275
[BP] GO:0016042 lipid catabolic process AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.21557
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.19097
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.18977
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DRD1, DYRK1A, F3, FLT3, FUT7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RELA, SRC, TNKS, TNKS2 3.18977
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DNMT1, DRD1, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, RELA, SRC, TYR 3.17698
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, RELA, SRC 3.17698
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.10598
[BP] GO:0019371 None AKR1C3, CBR1, PTGES 3.10598
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, KIT, RELA, TYR 3.06397
[BP] GO:0009987 cellular process ABCB1, ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 3.05504
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, MAP2K1, TNKS 3.0256
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.99525
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PIM1, PPARA, PTGES, TYR 2.9895
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MMP9, PTPN1, RELA, SRC, TERT 2.96259
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.9529
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, BACE1, CA2, CA7, DRD1, DRD2, KIT 2.91508
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, BACE1, CA2, CA7, DRD1, DRD2, KIT 2.91508
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.89721
[BP] GO:0016488 None AKR1B10, AKR1C3 2.89291
[BP] GO:0016487 None AKR1B10, AKR1C3 2.89291
[BP] GO:0016107 None AKR1B10, AKR1C3 2.89291
[BP] GO:0006714 None AKR1B10, AKR1C3 2.89291
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, DYRK1A, MAP2K1, TNKS 2.87602
[BP] GO:0048585 negative regulation of response to stimulus ALOX15, AR, BCL2, CYP19A1, DRD1, DRD2, DYRK1A, IGF1R, MET, MMP9, PPARA, PTPN1, PTPRS, RELA, SRC, TERT, XDH 2.85553
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DYRK1A, IGF1R, MET, MMP9, PTPN1, RELA, SRC, XDH 2.84829
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 2.83641
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, TNKS, TNKS2 2.80396
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, MAOA 2.7931
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, MAOA 2.7931
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.7931
[BP] GO:0007165 signal transduction AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CHRM2, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TNKS, TNKS2 2.79062
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, F3, KIT, MET, SRC 2.78419
[BP] GO:0065009 regulation of molecular function ABCB1, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, F3, FABP4, FLT3, IGF1R, KIT, MAP2K1, MAP3K7, MET, MMP9, PIM1, PPARA, PTPN1, RELA, SRC, TERT, TNKS, XDH 2.77109
[BP] GO:0042592 homeostatic process AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, FABP3, FABP4, FLT3, MET, SRC, TERT 2.75077
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.74126
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DNMT1, DRD1, DRD2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PTPN1, RELA, SRC 2.73123
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, MAP2K1, RELA, TYR 2.6358
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MAP3K7, MET, MMP2, MMP9, PTPN1, SRC 2.63075
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, HSD17B3, PTGES 2.63075
[BP] GO:0008542 None APP, DRD1, DRD2, KIT 2.62386
[BP] GO:0006950 response to stress ACHE, AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, KIT, MAP2K1, MAP3K7, MMP2, MMP9, PPARA, PTGES, PTPN1, RELA, SRC, TERT 2.61561
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DRD1, DYRK1A, FLT3, FUT7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, PIM1, PTPN1, PTPRS, SRC, TNKS, TNKS2 2.61319
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, DYRK1A, SRC, TNKS 2.60743
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PIM1, PPARA, PTGES, TYR 2.60743
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.58919
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, MAP2K1, TYR 2.58279
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CYP1B1, DRD2, F3, KDR, KIT, MAP2K1, PIM1, RELA, SRC, TERT 2.54254
[BP] GO:0050790 regulation of catalytic activity APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, F3, FABP4, FLT3, IGF1R, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, TERT, TNKS, XDH 2.53621
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PIM1, PPARA, PTGES, TYR 2.53621
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, BCL2, RELA, SRC, TERT 2.5295
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.52176
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 2.52142
[BP] GO:0032268 regulation of cellular protein metabolic process ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, RELA, SRC, XDH 2.51958
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.49292
[BP] GO:0016095 None AKR1B10, AKR1C3 2.49292
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC, TERT 2.49089
[BP] GO:0007632 None APP, DRD1, DRD2, KIT 2.49089
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.49089
[BP] GO:0010648 negative regulation of cell communication ACHE, AR, BCL2, DRD1, DRD2, DYRK1A, IGF1R, MET, MMP9, PTPN1, PTPRS, RELA, SRC, TERT, XDH 2.48575
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, DNMT1, DRD2, IGF1R, KDR, KIT, MAP2K1, MET, MMP1, MMP9, PTPN1, PTPRS, SRC, TNKS, TNKS2 2.48191
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, MMP9, RORC 2.47572
[BP] GO:0023057 negative regulation of signaling ACHE, AR, BCL2, DRD1, DRD2, DYRK1A, IGF1R, MET, MMP9, PTPN1, PTPRS, RELA, SRC, TERT, XDH 2.47521
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.47374
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, RELA, SRC 2.46509
[BP] GO:0009611 response to wounding ACHE, ALOX15, BCL2, CYP1A1, DRD2, PPARA 2.45313
[BP] GO:0019216 regulation of lipid metabolic process AKR1C3, CYP1A1, FABP3, FLT3, KIT, PPARA, RORC, SRC 2.44333
[BP] GO:0007166 cell surface receptor signaling pathway APP, AXL, BCL2, CA1, CSNK2A1, DRD2, F3, FLT3, IGF1R, KDR, KIT, MAP3K7, MET, MMP2, MMP9, PTPN1, RELA, SRC, TNKS, TNKS2 2.43405
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC, TERT 2.42787
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DRD1, DYRK1A, SRC, TNKS 2.39608
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, KDR, MAP2K1, PTPN1, SRC 2.36634
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP3A4, MAOA 2.36634
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.36634
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.36634
[BP] GO:0009892 negative regulation of metabolic process AKR1C3, APP, AR, AURKB, BCL2, CSNK2A1, DNMT1, DRD2, DYRK1A, FABP4, IGF1R, KDR, MAP2K1, MET, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.36413
[BP] GO:0051338 regulation of transferase activity APP, AURKB, CDC25B, DRD2, FABP4, FLT3, IGF1R, KIT, MAP2K1, MAP3K7, PTPN1, SRC, TNKS 2.36366
[BP] GO:0044092 negative regulation of molecular function APP, AURKB, CSNK2A1, CYP1B1, DRD2, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 2.36289
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.35671
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, PTGES, RELA, SRC 2.345
[BP] GO:0034502 protein localization to chromosome AURKB, TERT, TNKS, TNKS2 2.345
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.31774
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, KDR, MET, MMP9, SRC, TNKS, TNKS2 2.31512
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.31077
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KDR, RELA, SRC 2.30318
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA 2.29554
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CYP19A1, DRD1, DRD2, MAP2K1, MMP9, PPARA, PTPN1, SRC, TERT 2.29386
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, RELA 2.28017
[BP] GO:0050806 positive regulation of synaptic transmission APP, CA2, CA7, DRD1, DRD2 2.26454
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, KDR, MAP2K1, SRC 2.26172
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.26172
[BP] GO:0070213 None TNKS, TNKS2 2.25911
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.25911
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, SRC 2.24255
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC, TERT 2.23695
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DNMT1, DRD1, IGF1R, MMP2, RELA, SRC 2.23523
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.23425
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.21946
[BP] GO:0006081 None AKR1B10, AKR1C3, CYP1B1, RELA 2.2107
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, PTGES, RELA, SRC 2.19793
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, DNMT1, DRD1, DRD2, IGF1R, MAP2K1, MET, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2 2.19365
[BP] GO:1901575 None ACHE, AKR1B10, AKR1C3, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, MAOA, XDH 2.1773
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, FABP3, FABP4, KIT, MET 2.1773
[BP] GO:0048169 None APP, DRD2, KIT 2.1736
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, TNKS2 2.16766
[BP] GO:0080135 regulation of cellular response to stress APP, DYRK1A, IGF1R, MAP2K1, MAP3K7, MET, PTPN1, PTPRS, TERT, XDH 2.16109
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, DRD1, DRD2, F3, FABP4, KDR, MAP2K1, MET, PPARA, PTPRS, RELA 2.16109
[BP] GO:0045859 regulation of protein kinase activity APP, CDC25B, DRD2, FABP4, FLT3, IGF1R, KIT, MAP2K1, MAP3K7, PTPN1, SRC 2.1332
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.13123
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.13123
[BP] GO:0051239 regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CACNA1C, CHRM2, CYP1B1, DRD2, F3, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIM1, PTPRS, RELA, SRC, TERT, TNKS2, XDH 2.12723
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, IGF1R, SRC, TNKS, TNKS2 2.11144
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.10581
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.09195
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, FABP3, FABP4, MET 2.08943
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.08943
[BP] GO:0048638 regulation of developmental growth APP, AR, BCL2, DRD2, PIM1, PTPRS, TNKS2 2.08943
[BP] GO:0008306 None APP, DRD1, DRD2, KIT 2.08857
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.08768
[BP] GO:0043085 positive regulation of catalytic activity APP, AURKB, BCL2, CDC25B, DRD2, F3, FLT3, KIT, MAP2K1, MAP3K7, PTPN1, SRC, TERT, TNKS, XDH 2.08651
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, F3, FLT3, FUT7, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RELA, RORC, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.08651
[BP] GO:0021853 None DRD1, DRD2 2.08651
[BP] GO:0010641 None F3, SRC 2.08651
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.08651
[BP] GO:1904936 None DRD1, DRD2 2.08651
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, APP, AR, AURKB, BCL2, CSNK2A1, DNMT1, DRD2, DYRK1A, FABP4, IGF1R, MET, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.08651
[BP] GO:0009314 response to radiation APP, AURKB, BCL2, DRD1, DRD2, KIT, RELA, TYR 2.08191
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.07945
[BP] GO:0030100 regulation of endocytosis ALOX15, APP, AXL, DRD2, PTPN1, SRC 2.06946
[BP] GO:0042417 None DRD1, DRD2, MAOA 2.0624
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, HSD17B3 2.0624
[BP] GO:0051246 regulation of protein metabolic process ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, RELA, SRC, XDH 2.05377
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DNMT1, DRD1, IGF1R, MMP2, RELA, SRC 2.04755
[BP] GO:0071383 None AKR1C3, AR, FLT3, SRC 2.04091
[BP] GO:0065007 biological regulation ABCB1, ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.03759
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CYP1A1, RELA, SRC, TYR 2.02375
[BP] GO:0042181 None AKR1C3, CYP19A1, HSD17B3 2.02375
[BP] GO:0051347 positive regulation of transferase activity AURKB, CDC25B, DRD2, FLT3, KIT, MAP2K1, MAP3K7, PTPN1, SRC, TNKS 2.01333
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, TERT 2.0023
[CC] GO:0016020 membrane ABCB1, ACHE, ALOX15, ALOX5, ALPL, APP, AR, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD1, DRD2, F3, FLT3, FUT7, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTGES, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TYR 3.8336
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.49716
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, AR, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CBR1, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD1, DRD2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSD17B3, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, PTGES, PTPN1, PTPRS, RELA, SRC, TERT, TNKS, TNKS2, TYR, XDH 3.46989
[CC] GO:0043226 organelle ABCB1, ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA9, CACNA1C, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, FUT7, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RELA, RORC, SHBG, SRC, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 3.25538
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, AKR1B1, AKR1B10, AKR1C3, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, FUT7, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RELA, RORC, SHBG, SRC, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 3.23455
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ALOX15, ALPL, APP, AR, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CSNK2A1, DRD1, DRD2, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTPN1, PTPRS, SRC, TERT 2.78473
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD1, FLT3, HSD17B2, HSD17B3, PTGES, PTPN1 2.46689
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DNMT1, DYRK1A, F3, FLT3, FUT7, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PTGES, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 12.8869
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 12.4208
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DNMT1, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 12.1188
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.90696
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 7.29097
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4 6.68308
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.30214
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, TYR 6.11459
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DNMT1, DRD1, DRD2, KIT, MAP3K7, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, TYR, XDH 6.11041
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, PPARA, SRC 5.96175
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, XDH 5.70561
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.52586
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 5.295
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.295
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, CBR1, HSD17B1, HSD17B2, HSD17B3, XDH 5.06902
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DNMT1, KIT, MAP3K7, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, TYR, XDH 4.75879
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, TYR 4.69679
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.66501
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, MMP1, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS 4.48309
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, CBR1, HSD17B1, HSD17B2, HSD17B3 4.31173
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, SRC 4.13731
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.12799
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC 4.0594
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.0089
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, SRC 3.97499
[MF] GO:0047035 testosterone dehydrogenase (NAD+) activity AKR1C3, HSD17B2, HSD17B3 3.85494
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD17B1, HSD17B2, HSD17B3 3.49134
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD17B1, HSD17B2, HSD17B3 3.37516
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC 3.35319
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.35267
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, AURKB, AXL, CSNK2A1, DYRK1A, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, PTGES, PTPRS, RELA, SRC, TUBB3, XDH 3.34135
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.29557
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A6, CYP3A4 3.1452
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, HSD17B1, PTGES, SRC, XDH 3.06113
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC 2.99601
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TERT 2.91928
[MF] GO:0045550 None AKR1B10, AKR1C3 2.89291
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, SHBG 2.87602
[MF] GO:0005496 steroid binding AR, CYP3A4, HSD17B1, RORC, SHBG 2.85521
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, XDH 2.76247
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, CYP3A4, F3, FABP3, FABP4, HSD17B1, PPARA, RORC, SHBG 2.62338
[MF] GO:0047718 None AKR1B10, AKR1C3 2.49292
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.49292
[MF] GO:0047045 None AKR1C3, HSD17B3 2.49292
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, DRD2, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP3K7, MET, MMP9, RELA, TERT, TYR, XDH 2.44384
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CSNK2A1, DYRK1A, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, PTPRS, SRC 2.40888
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.25911
[MF] GO:0005497 None AR, SHBG 2.25911
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.25911
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.13123
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.08651


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, CYP19A1, IGF1R 9.4336
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, AKR1C3, CYP1B1, CYP3A4, CYP19A1 10.4836
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.8511
Metabolic pathways_Homo sapiens_hsa01100 CBR1, DNMT1, MAOA, ALOX15, HSD17B3, AKR1C3, AKR1B1, TYR, CYP3A4, CYP19A1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, PTGES 7.6115
Pathways in cancer_Homo sapiens_hsa05200 AR, MAP2K1, FLT3, MMP1, MMP2, KIT, BCL2, MMP9, MET, RELA, IGF1R 5.4278
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.2839
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 5.2839
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 5.2021
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, DNMT1, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 4.8911
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.1647
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, KIT, PIM1, RELA 4.6496
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOA, ALOX5, ALOX15, CACNA1C 4.5184
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, AKR1C3, PTGES 4.5184
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, MMP2, KDR, MMP9, MET, IGF1R 4.1591
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, MAP2K1, CACNA1C, DRD1, DRD2, PPARA, RELA 4.1878
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, KIT, KDR, DRD2, MET, IGF1R 4.0756
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, MAP2K1, KIT, KDR, BCL2, MET, RELA, IGF1R 3.7317
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, BCL2, RELA, IGF1R 3.9122
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3, RELA 3.7062
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC, TUBB3, DRD1, DRD2 3.914
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, MAP2K1, BCL2, CACNA1C 3.5272
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, SRC, KDR, BCL2, MET, IGF1R 3.3123
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 3.9788
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, KIT, KDR, MET, RELA, IGF1R 3.1191
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, SRC, BCL2, MMP9, RELA 3.0878
Cocaine addiction_Homo sapiens_hsa05030 MAOA, DRD1, DRD2, RELA 3.7111
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, KIT, MET 3.2619
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 3.2971
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2, CYP3A4 3.243
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.8336
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, MMP2, MMP9 2.7194
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.7178
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.243
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, BCL2, RELA, IGF1R 2.6782
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, MAP3K7, RELA 2.8105
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MMP9, MAP3K7, RELA 2.5931
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, MAP3K7, RELA 2.4895
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C, DRD1, DRD2 2.3558
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 2.1505
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.145
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA, DRD1, DRD2 1.9318
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, MAP3K7, RELA 1.7783
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C, DRD1 2.1842
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR 2.2918
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, CDC25B, IGF1R 1.8005
Melanoma_Homo sapiens_hsa05218 MAP2K1, MET, IGF1R 2.1505
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, SRC, RELA 2.145
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, KIT, TYR 1.7899
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.1757
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.7508
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.7662
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA, RELA 1.7247
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, CYP3A4 2.1505
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, BCL2, RELA 1.6385
Apoptosis_Homo sapiens_hsa04210 MAP2K1, BCL2, RELA 1.4839
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.4658
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.616
Measles_Homo sapiens_hsa05162 CSNK2A1, MAP3K7, RELA 1.5112
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.5396
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, BCL2, RELA 1.6385
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C 1.3633
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP, CACNA1C 1.3209
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.6073
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CACNA1C, DRD1 1.2945
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.2945
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.2808
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, SRC, RELA 1.2772
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, MAP2K1, SRC 1.1572
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, DRD1, DRD2 0.9201
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3399
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3504
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, IGF1R 0.8904
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.87
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1 0.87
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.87
AMPK signaling pathway_Homo sapiens_hsa04152 MAP3K7, IGF1R 0.9307
Hepatitis C_Homo sapiens_hsa05160 PPARA, RELA 0.8904
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3781
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9598
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.1191
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, SRC 0.9598
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, IGF1R 0.87
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, MAP3K7 0.87
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.9512
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, KIT 0.8674
HTLV-I infection_Homo sapiens_hsa05166 TERT, RELA 0.5611
Viral carcinogenesis_Homo sapiens_hsa05203 SRC, RELA 0.6733
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, CACNA1C 0.8548
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.4199
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA, RELA 0.8474
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.8254
Influenza A_Homo sapiens_hsa05164 MAP2K1, RELA 0.763
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, CACNA1C 0.7899
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, SRC 1.1605
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 RELA, IGF1R 1.1176
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4441
Axon guidance_Homo sapiens_hsa04360 MET 0.4383
Platelet activation_Homo sapiens_hsa04611 SRC 0.4472
Glioma_Homo sapiens_hsa05214 MAP2K1, IGF1R 1.3209
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4685
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.1605
Small cell lung cancer_Homo sapiens_hsa05222 BCL2, RELA 1.1646
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.1605
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.3529
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, RELA 1.2808
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, RELA 1.2808
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 RELA 0.4988
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.3209
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5068
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1 0.5068
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, BCL2 1.3321
Amoebiasis_Homo sapiens_hsa05146 RELA 0.5068
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, RELA 1.3209
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.5157
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5072
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5133
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5122
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.5133
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.5068
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.3209
Morphine addiction_Homo sapiens_hsa05032 DRD1 0.5209
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.2945
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2375
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5223
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC, RELA 1.3209
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.5223
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.3765
Leishmaniasis_Homo sapiens_hsa05140 MAP3K7, RELA 1.2808
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.5384
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3606
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5223
Salmonella infection_Homo sapiens_hsa05132 RELA 0.5308
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5322
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.3209
Peroxisome_Homo sapiens_hsa04146 XDH 0.5384
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5388
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.2945
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5471
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5384
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5453
Pertussis_Homo sapiens_hsa05133 RELA 0.5591
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5611
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.5845
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5611
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6048
Renin secretion_Homo sapiens_hsa04924 CACNA1C 0.6048
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.6048
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.6478
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1 0.6478
Legionellosis_Homo sapiens_hsa05134 RELA 0.6484
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1 0.6641
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.6484
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6686
Malaria_Homo sapiens_hsa05144 MET 0.6745
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6733
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8005
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6794
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7075
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.1647
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.7018
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.7233
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7693
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7064
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.7426
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.7899
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.8474
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0038
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.8674
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8289
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.87
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8389
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8674
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8811
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9918
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0694


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)