Natural Product: NPC75204

Natural Product ID:  NPC75204
Common Name:   (E)-Hex-2-Enal
IUPAC Name:   (E)-hex-2-enal
Synonyms:  
Molecular Formula:   C6H10O
Standard InCHIKey:  MBDOYVRWFFCFHM-SNAWJCMRSA-N
Standard InCHI:  InChI=1S/C6H10O/c1-2-3-4-5-6-7/h4-6H,2-3H2,1H3/b5-4+
Canonical SMILES:  CCC/C=C/C=O
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO16087 Atractylodes lancea Species Asteraceae Eukaryota TM-MC*
NPO4795.1 Prunus armeniaca var. ansu Varieties Rosaceae Eukaryota TCMID*
NPO14747 Usnea florida Species Parmeliaceae Eukaryota UNPD*
NPO14604 Dipteronia dyeriana Species Aceraceae Eukaryota UNPD*
NPO13077 Amygdalus communis vas NA NA NA TCMSP*
NPO20902 Atractylodes macrocephala Species Asteraceae Eukaryota TM-MC*
NPO420 Eucheuma muricatum Species Solieriaceae Eukaryota TCMID*
NPO8671 Physalis solanaceus Species Solanaceae Eukaryota UNPD*
NPO12547 Viburnum chingii Species Adoxaceae Eukaryota UNPD*
NPO23624 Thalluslaminariae NA NA NA TCMSP*
NPO16501 Capsicum annuum Species Solanaceae Eukaryota TM-MC*
NPO25426 Arachis hypogaea Species Fabaceae Eukaryota TCMID*
NPO16109 Actinidia kolomikta Species Actinidiaceae Eukaryota UNPD*
NPO4795 Prunus armeniaca Species Rosaceae Eukaryota UNPD*
NPO29545 Capsici fructus NA NA NA TCMSP*
NPO9445 Crocus sativus Species Iridaceae Eukaryota TM-MC*
NPO26327 Chaenomeles sinensis Species Rosaceae Eukaryota TCMID*
NPO7718 Peucedanum palustre Species Apiaceae Eukaryota UNPD*
NPO13582 Leucopaxillus giganteus Species Tricholomataceae Eukaryota UNPD*
NPO29654 Lonicerae japonicae flos NA NA NA TCMSP*
NPO14914 Esox saurus Species Esocidae Eukaryota UNPD*
NPO26439 Folium artemisiae argyi NA NA NA TCMSP*
NPO21355 Elsholtzia ciliata Species Lamiaceae Eukaryota TM-MC*
NPO23332.1 Dendrobium fimbriatum var. oculatum Varieties Orchidaceae Eukaryota TCMID*
NPO5750 Monomorium floricola Species Formicidae Eukaryota UNPD*
NPO4083 Brevibacillus laterosporus Species Paenibacillaceae Bacteria UNPD*
NPO29555 Evodiae fructus NA NA NA TCMSP*
NPO28295 Foeniculum vulgare Species Apiaceae Eukaryota TM-MC*
NPO22234 Ficus carica Species Moraceae Eukaryota TCMID*
NPO11376 Schistostephium rotundifolium Species Asteraceae Eukaryota UNPD*
NPO2607 Ophiorrhiza blumeana Species Rubiaceae Eukaryota UNPD*
NPO29546 Eriobotryae folium NA NA NA TCMSP*
NPO13879 Humulus lupulus Species Cannabaceae Eukaryota TM-MC*
NPO7077 Canarium strictum Species Burseraceae Eukaryota UNPD*
NPO26256 Zanthoxylum chiriquinum Species Rutaceae Eukaryota UNPD*
NPO1723 Sideritis syriaca Species Lamiaceae Eukaryota UNPD*
NPO29631 Dichroae radix NA NA NA TCMSP*
NPO4391 Hypericum perforatum Species Hypericaceae Eukaryota TM-MC*
NPO13427 Erinaceus europaeus Species Erinaceidae Eukaryota UNPD*
NPO12457 Siphocampylus verticillatus Species Campanulaceae Eukaryota UNPD*
NPO15159 Podocarpus salignus Species Podocarpaceae Eukaryota UNPD*
NPO4054 Lysimachiae foenigraeci herba NA NA NA TCMSP*
NPO14650 Lobelia chinensis Species Campanulaceae Eukaryota TM-MC*
NPO16625 Phalaenopsis aphrodite Species Orchidaceae Eukaryota UNPD*
NPO15178 Psychotria bahiensis Species Rubiaceae Eukaryota UNPD*
NPO29614 Polygonati odorati rhizoma NA NA NA TCMSP*
NPO1515 Lonicera japonica Species Caprifoliaceae Eukaryota TM-MC*
NPO15679 Amyris marshii Species Rutaceae Eukaryota UNPD*
NPO15884 Dodonaea polyandra Species Sapindaceae Eukaryota UNPD*
NPO29719 Ginkgo biloba Species Ginkgoaceae Eukaryota TCMSP*
NPO7792 Coreopsis grandiflora Species Asteraceae Eukaryota UNPD*
NPO11962 Garcinia macrophylla Species Clusiaceae Eukaryota UNPD*
NPO9386 Ectropis bicolor Species Geometridae Eukaryota UNPD*
NPO29560 Carthami flos NA NA NA TCMSP*
NPO6978 Boronella koniambiensis Species Rutaceae Eukaryota UNPD*
NPO13740 Aconitum kamtschaticum Species Ranunculaceae Eukaryota UNPD*
NPO28184 Folium nelumbinis NA NA NA TCMSP*
NPO13952 Streptomyces lavendulae Species Streptomycetaceae Bacteria UNPD*
NPO16307 Murraya kwangsiensis Species Rutaceae Eukaryota UNPD*
NPO29629 Viticis negundo folium Species Curculionidae Eukaryota TCMSP*
NPO651 Aconitum vilmorinianum Species Ranunculaceae Eukaryota UNPD*
NPO16755 Saposhnikovia divaricata Species Apiaceae Eukaryota HerDing*
NPO22874 Bombyx mori Species Bombycidae Eukaryota TCMSP*
NPO13273 Maytenus loeseneri Species Celastraceae Eukaryota UNPD*
NPO1797 Homo sapiens Species Hominidae Eukaryota blood PMID[22626821]
NPO29685 Eucommiae folium NA NA NA TCMSP*
NPO12470 Brachyspira hyodysenteriae Species Brachyspiraceae Bacteria UNPD*
NPO1797 Homo sapiens Species Hominidae Eukaryota saliva PMID[24421258]
NPO4750 Meliae azedarach fructus NA NA NA TCMSP*
NPO23256 Mentha arvensis Species Lamiaceae Eukaryota TM-MC*
NPO16541 Veratrum stenophyllum Species Melanthiaceae Eukaryota UNPD*
NPO1797 Homo sapiens Species Hominidae Eukaryota Faeces PMID[17314143]
NPO29463 Pogostemon cablin Species Lamiaceae Eukaryota TCMSP*
NPO13857 Mentha canadensis Species Lamiaceae Eukaryota TM-MC*
NPO22056.1 Streptomyces fervens Subspecies Streptomycetaceae Bacteria UNPD*
NPO26707 Bidentis bipinnatae herba NA NA NA TCMSP*
NPO18046 Mosla chinensis Species Lamiaceae Eukaryota TM-MC*
NPO11644 Prosopis ruscifolia Species Fabaceae Eukaryota UNPD*
NPO2997 Aloe africana Species Xanthorrhoeaceae Eukaryota TM-MC*
NPO3478 Nelumbo nucifera Species Nelumbonaceae Eukaryota TM-MC*
NPO22053 Vepris pilosa Species Rutaceae Eukaryota UNPD*
NPO11578 Aloe vera Species Xanthorrhoeaceae Eukaryota TM-MC*
NPO8650 Perilla frutescens Species Lamiaceae Eukaryota TM-MC*
NPO15570 Plectranthus mollis Species Lamiaceae Eukaryota UNPD*
NPO14763 Aloe ferox Species Asphodelaceae Eukaryota TM-MC*
NPO4795 Prunus armeniaca Species Rosaceae Eukaryota TM-MC*
NPO10899 Ophioparma ventosa Species Ophioparmaceae Eukaryota UNPD*
NPO2837 Aloe spicata Species Asphodelaceae Eukaryota TM-MC*
NPO25099 Prunus mandshurica Species Rosaceae Eukaryota TM-MC*
NPO14111 Maytenus serrata Species Celastraceae Eukaryota UNPD*
NPO2921 Angelica acutiloba Species Apiaceae Eukaryota TM-MC*
NPO20032 Prunus sibirica Species Rosaceae Eukaryota TM-MC*
NPO14442 Gouania microcarpa Species Gobiesocidae Eukaryota UNPD*
NPO26589 Artemisia annua Species Asteraceae Eukaryota TCM_Taiwan*
NPO11438 Angelica gigas Species Apiaceae Eukaryota TM-MC*
NPO21349 Punica granatum Species Lythraceae Eukaryota TM-MC*
NPO15434 Rhodomicrobium vannielii Species Hyphomicrobiaceae Bacteria UNPD*
NPO4795.1 Prunus armeniaca var. ansu Varieties Rosaceae Eukaryota HerDing*
NPO15462 Angelica sinensis Species Apiaceae Eukaryota TM-MC*
NPO16039 Scutellaria barbata Species Lamiaceae Eukaryota TM-MC*
NPO15312 Coelogorgia palmosa Species Coelogorgiidae Eukaryota UNPD*
NPO4795.2 Prunus armeniaca l. var. ansu maxim. Varieties Rosaceae Eukaryota TCM_Taiwan*
NPO26589 Artemisia annua Species Asteraceae Eukaryota TM-MC*
NPO2943 Sraitia grosvenorii NA NA NA TM-MC*
NPO5482 Gymnanthemum amygdalinum Species Asteraceae Eukaryota UNPD*
NPO21891 Panax notoginseng Species Araliaceae Eukaryota TCMSP*
NPO10506 Artemisia apiacea Species Asteraceae Eukaryota TM-MC*
NPO15810 Zea mays Species Poaceae Eukaryota TM-MC*
NPO3697 Ongokea klaineana Species Aptandraceae Eukaryota UNPD*
NPO26257 Celastri orbiculati fructus NA NA NA TCMSP*
NPO28276 Artemisia argyi Species Asteraceae Eukaryota TM-MC*
NPO7591 Cedrus deodara Species Pinaceae Eukaryota TCMID*
NPO11100 Artemisia capillaris Species Asteraceae Eukaryota TM-MC*
NPO10219 Juniperus communis Species Cupressaceae Eukaryota TCMID*
NPO16311 Rusavskia elegans Species Teloschistaceae Eukaryota UNPD*
NPO29641 Rhododendri daurici folium NA NA NA TCMSP*
NPO10492 Artemisia montana Species Asteraceae Eukaryota TM-MC*
NPO16755 Saposhnikovia divaricata Species Apiaceae Eukaryota TCMID*
NPO10452 Odontites rubra Species Orobanchaceae Eukaryota UNPD*
NPO23080 Benincasae exocarpium NA NA NA TCMSP*
NPO25094 Artemisia princeps Species Asteraceae Eukaryota TM-MC*
NPO310 Flos mume Species Lycaenidae Eukaryota TCMID*
NPO12951 Talaromyces coalescens Species Trichocomaceae Eukaryota UNPD*
NPO29677 Scutellariae barbatae herba NA NA NA TCMSP*

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT2241 Organism Glomerella acutata Glomerella acutata Activity = 100 % 17567029
NPT2241 Organism Glomerella acutata Glomerella acutata Activity = 87.5 % 17567029
NPT2241 Organism Glomerella acutata Glomerella acutata ID50 = 26.89 uL/L 17567029
NPT2241 Organism Glomerella acutata Glomerella acutata ID95 = 32.97 uL/L 17567029
NPT348 Organism Myzus persicae Myzus persicae LD90 = 54.4 ug/ml 10995371
NPT348 Organism Myzus persicae Myzus persicae LD50 = 24.3 ug/ml 10995371
NPT849 Organism Plutella xylostella Plutella xylostella Activity = 50 % 11312775
NPT849 Organism Plutella xylostella Plutella xylostella Activity = 20 % 11312775
NPT849 Organism Plutella xylostella Plutella xylostella Activity = 25 % 11312775
NPT849 Organism Plutella xylostella Plutella xylostella Activity = 85 % 11312775
NPT849 Organism Plutella xylostella Plutella xylostella Activity = 90 % 11312775
NPT849 Organism Plutella xylostella Plutella xylostella Activity = 55 % 11312775
NPT849 Organism Plutella xylostella Plutella xylostella Activity = 15 % 11312775
NPT849 Organism Plutella xylostella Plutella xylostella Activity = 30 % 11312775
NPT563 Organism Escherichia coli O157:H7 Escherichia coli O157:H7 GI = 97.3 % 14969531
NPT563 Organism Escherichia coli O157:H7 Escherichia coli O157:H7 GI = 89.9 % 14969531
NPT563 Organism Escherichia coli O157:H7 Escherichia coli O157:H7 GI = 47.5 % 14969531
NPT563 Organism Escherichia coli O157:H7 Escherichia coli O157:H7 GI = 25.5 % 14969531
NPT563 Organism Escherichia coli O157:H7 Escherichia coli O157:H7 GI = 8.2 % 14969531
NPT563 Organism Escherichia coli O157:H7 Escherichia coli O157:H7 GI = 7.3 % 14969531
NPT16 Organism Staphylococcus aureus Staphylococcus aureus GI = 100 % 14969531
NPT16 Organism Staphylococcus aureus Staphylococcus aureus GI = 96.7 % 14969531
NPT16 Organism Staphylococcus aureus Staphylococcus aureus GI = 72.6 % 14969531
NPT16 Organism Staphylococcus aureus Staphylococcus aureus GI = 44.3 % 14969531
NPT16 Organism Staphylococcus aureus Staphylococcus aureus GI = 28.7 % 14969531
NPT16 Organism Staphylococcus aureus Staphylococcus aureus GI = 29.2 % 14969531
NPT564 Organism Listeria monocytogenes Listeria monocytogenes GI = 99.8 % 14969531
NPT564 Organism Listeria monocytogenes Listeria monocytogenes GI = 99.4 % 14969531
NPT564 Organism Listeria monocytogenes Listeria monocytogenes GI = 81.2 % 14969531
NPT564 Organism Listeria monocytogenes Listeria monocytogenes GI = 45.3 % 14969531
NPT564 Organism Listeria monocytogenes Listeria monocytogenes GI = 32 % 14969531
NPT564 Organism Listeria monocytogenes Listeria monocytogenes GI = 31 % 14969531
NPT565 Organism Vibrio parahaemolyticus Vibrio parahaemolyticus GI = 99.8 % 14969531
NPT565 Organism Vibrio parahaemolyticus Vibrio parahaemolyticus GI = 100 % 14969531
NPT565 Organism Vibrio parahaemolyticus Vibrio parahaemolyticus GI = 99.6 % 14969531
NPT565 Organism Vibrio parahaemolyticus Vibrio parahaemolyticus GI = 84.7 % 14969531
NPT566 Organism Salmonella typhimurium Salmonella enterica subsp. enterica serovar Typhimurium GI = 99.4 % 14969531
NPT566 Organism Salmonella typhimurium Salmonella enterica subsp. enterica serovar Typhimurium GI = 98.9 % 14969531
NPT566 Organism Salmonella typhimurium Salmonella enterica subsp. enterica serovar Typhimurium GI = 98.5 % 14969531
NPT566 Organism Salmonella typhimurium Salmonella enterica subsp. enterica serovar Typhimurium GI = 83.4 % 14969531
NPT566 Organism Salmonella typhimurium Salmonella enterica subsp. enterica serovar Typhimurium GI = 63 % 14969531
NPT566 Organism Salmonella typhimurium Salmonella enterica subsp. enterica serovar Typhimurium GI = 47.1 % 14969531
NPT314 Organism Bacillus cereus Bacillus cereus GI = 100 % 14969531
NPT314 Organism Bacillus cereus Bacillus cereus GI = 98.7 % 14969531
NPT314 Organism Bacillus cereus Bacillus cereus GI = 91.8 % 14969531
NPT314 Organism Bacillus cereus Bacillus cereus GI = 91.3 % 14969531
NPT314 Organism Bacillus cereus Bacillus cereus GI = 90.5 % 14969531
NPT563 Organism Escherichia coli O157:H7 Escherichia coli O157:H7 GI = 99.9 % 14969531
NPT564 Organism Listeria monocytogenes Listeria monocytogenes GI = 99.7 % 14969531
NPT566 Organism Salmonella typhimurium Salmonella enterica subsp. enterica serovar Typhimurium GI = 98.7 % 14969531
NPT314 Organism Bacillus cereus Bacillus cereus GI = 98.8 % 14969531
NPT2 Others Unspecified Potency 594.6 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 21271.7 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 27306 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 59455.9 nM PubChem BioAssay data set

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC75204 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.9706 High Similarity NPC279300
0.9697 High Similarity NPC72258
0.9167 High Similarity NPC33761
0.9143 High Similarity NPC8416
0.8919 High Similarity NPC323278
0.8684 High Similarity NPC33489
0.8611 High Similarity NPC254764
0.8462 Intermediate Similarity NPC67920
0.8462 Intermediate Similarity NPC287397
0.8462 Intermediate Similarity NPC298710
0.8462 Intermediate Similarity NPC208936
0.8421 Intermediate Similarity NPC12319
0.8421 Intermediate Similarity NPC101147
0.8421 Intermediate Similarity NPC18205
0.8182 Intermediate Similarity NPC8466
0.8 Intermediate Similarity NPC144407
0.7778 Intermediate Similarity NPC146507
0.7714 Intermediate Similarity NPC273054
0.75 Intermediate Similarity NPC109034
0.75 Intermediate Similarity NPC324812
0.7297 Intermediate Similarity NPC310810
0.725 Intermediate Similarity NPC217923
0.7105 Intermediate Similarity NPC269641
0.7027 Intermediate Similarity NPC266979
0.697 Remote Similarity NPC235797
0.6957 Remote Similarity NPC477789
0.6905 Remote Similarity NPC221250
0.6842 Remote Similarity NPC12889
0.675 Remote Similarity NPC24833
0.6667 Remote Similarity NPC155900
0.6667 Remote Similarity NPC113082
0.6667 Remote Similarity NPC30433
0.6667 Remote Similarity NPC239754
0.6667 Remote Similarity NPC58957
0.6667 Remote Similarity NPC234829
0.6667 Remote Similarity NPC8270
0.6667 Remote Similarity NPC111474
0.6591 Remote Similarity NPC106819
0.6591 Remote Similarity NPC216921
0.6585 Remote Similarity NPC226511
0.6579 Remote Similarity NPC63121
0.6579 Remote Similarity NPC197356
0.6579 Remote Similarity NPC304788
0.6522 Remote Similarity NPC110234
0.6522 Remote Similarity NPC44363
0.6522 Remote Similarity NPC163751
0.6471 Remote Similarity NPC317899
0.6458 Remote Similarity NPC275316
0.6444 Remote Similarity NPC145755
0.6444 Remote Similarity NPC267514
0.6444 Remote Similarity NPC114841
0.641 Remote Similarity NPC250734
0.6364 Remote Similarity NPC57923
0.6346 Remote Similarity NPC477790
0.6286 Remote Similarity NPC94980
0.6279 Remote Similarity NPC123357
0.6275 Remote Similarity NPC209431
0.6275 Remote Similarity NPC100809
0.6226 Remote Similarity NPC321568
0.6226 Remote Similarity NPC281986
0.6226 Remote Similarity NPC208749
0.6226 Remote Similarity NPC22019
0.619 Remote Similarity NPC155880
0.619 Remote Similarity NPC40434
0.619 Remote Similarity NPC130923
0.619 Remote Similarity NPC92863
0.619 Remote Similarity NPC34873
0.617 Remote Similarity NPC22098
0.617 Remote Similarity NPC195246
0.617 Remote Similarity NPC276009
0.6154 Remote Similarity NPC188789
0.6136 Remote Similarity NPC7754
0.6136 Remote Similarity NPC270170
0.6122 Remote Similarity NPC15789
0.6122 Remote Similarity NPC236338
0.6098 Remote Similarity NPC38497
0.6087 Remote Similarity NPC477686
0.6087 Remote Similarity NPC471753
0.6047 Remote Similarity NPC277382
0.6047 Remote Similarity NPC171978
0.6047 Remote Similarity NPC15934
0.6 Remote Similarity NPC82465
0.6 Remote Similarity NPC187922
0.5962 Remote Similarity NPC300121
0.5957 Remote Similarity NPC474202
0.5957 Remote Similarity NPC166788
0.5957 Remote Similarity NPC270706
0.5957 Remote Similarity NPC158853
0.5957 Remote Similarity NPC474362
0.5957 Remote Similarity NPC191337
0.5952 Remote Similarity NPC185839
0.5909 Remote Similarity NPC48930
0.587 Remote Similarity NPC301972
0.587 Remote Similarity NPC292463
0.5833 Remote Similarity NPC100380
0.5833 Remote Similarity NPC471752
0.5833 Remote Similarity NPC128280
0.5818 Remote Similarity NPC21946
0.5814 Remote Similarity NPC180840
0.58 Remote Similarity NPC118788
0.58 Remote Similarity NPC288381
0.58 Remote Similarity NPC220191
0.58 Remote Similarity NPC225974
0.58 Remote Similarity NPC20934
0.58 Remote Similarity NPC15325
0.5778 Remote Similarity NPC469713
0.5745 Remote Similarity NPC12907
0.5745 Remote Similarity NPC6963
0.5745 Remote Similarity NPC25771
0.5745 Remote Similarity NPC304079
0.5745 Remote Similarity NPC106547
0.5741 Remote Similarity NPC472808
0.5741 Remote Similarity NPC324224
0.5714 Remote Similarity NPC471958
0.5686 Remote Similarity NPC22329
0.5682 Remote Similarity NPC255042
0.5682 Remote Similarity NPC182840
0.5682 Remote Similarity NPC29091
0.5682 Remote Similarity NPC103213
0.566 Remote Similarity NPC159535
0.566 Remote Similarity NPC151761
0.5652 Remote Similarity NPC206906
0.5652 Remote Similarity NPC304151
0.5636 Remote Similarity NPC129150
0.5636 Remote Similarity NPC71755
0.5636 Remote Similarity NPC294938
0.5625 Remote Similarity NPC110396
0.5625 Remote Similarity NPC47946
0.5625 Remote Similarity NPC26600
0.561 Remote Similarity NPC81989
0.56 Remote Similarity NPC145311
0.56 Remote Similarity NPC207815

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC75204 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.6364 Remote Similarity NPD9297 Discontinued
0.6364 Remote Similarity NPD9091 Suspended
0.6087 Remote Similarity NPD6097 Approved
0.6087 Remote Similarity NPD6096 Approved
0.5957 Remote Similarity NPD9090 Phase 3
0.5714 Remote Similarity NPD5343 Approved
0.5682 Remote Similarity NPD5783 Phase 3
0.56 Remote Similarity NPD4220 Pre-registration

Structure

External Identifiers

PubChem CID   5281168
ChEMBL   CHEMBL2228570
ZINC  

Physicochemical Properties

Molecular Weight:  98.07
ALogP:  0.1876
MLogP:  2.01
XLogP:  1.85
# Rotatable Bonds:  4
Polar Surface Area:  17.07
# H-Bond Aceptor:  1
# H-Bond Donor:  0
# Rings:  0
# Heavy Atoms:  7

Download Data

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General Info & Identifiers & Properties  
Structure MOL file  
Source Organisms  
Biological Activities  
Similar NPs/Drugs