Natural Product: NPC47883

Natural Product ID:  NPC47883
Common Name:   2,8-Dihydroxy-6-(3,3',4'-Trihydroxy-Biphenyl-4-Yloxy)-Dibenzofuran-3-Carboxylic Acid
IUPAC Name:   6-[4-(3,4-dihydroxyphenyl)-2-hydroxyphenoxy]-2,8-dihydroxydibenzofuran-3-carboxylic acid
Synonyms:  
Molecular Formula:   C25H16O9
Standard InCHIKey:  VRTKLDOVWDISRQ-UHFFFAOYSA-N
Standard InCHI:  InChI=1S/C25H16O9/c26-13-7-15-14-9-18(28)16(25(31)32)10-22(14)34-24(15)23(8-13)33-21-4-2-12(6-20(21)30)11-1-3-17(27)19(29)5-11/h1-10,26-30H,(H,31,32)
Canonical SMILES:  Oc1cc(Oc2ccc(cc2O)c2ccc(c(c2)O)O)c2c(c1)c1cc(O)c(cc1o2)C(=O)O
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO21285 Cladophora socialis Species Cladophoraceae Eukaryota PMID[17949055]

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT178 Individual Protein Protein-tyrosine phosphatase 1B Homo sapiens IC50 = 3710 nM 23964704

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC47883 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.9765 High Similarity NPC248315
0.9706 High Similarity NPC226725
0.9647 High Similarity NPC154527
0.9643 High Similarity NPC98546
0.9643 High Similarity NPC297807
0.9464 High Similarity NPC216842
0.9464 High Similarity NPC82217
0.9464 High Similarity NPC476640
0.9458 High Similarity NPC470704
0.9408 High Similarity NPC287243
0.9405 High Similarity NPC54098
0.9405 High Similarity NPC230619
0.9353 High Similarity NPC8127
0.9353 High Similarity NPC49667
0.9349 High Similarity NPC149846
0.9345 High Similarity NPC476641
0.9306 High Similarity NPC71260
0.9235 High Similarity NPC65885
0.9205 High Similarity NPC295436
0.9176 High Similarity NPC174700
0.9128 High Similarity NPC471841
0.9123 High Similarity NPC473834
0.9107 High Similarity NPC29411
0.9107 High Similarity NPC36320
0.9107 High Similarity NPC45449
0.908 High Similarity NPC475996
0.9059 High Similarity NPC280493
0.9059 High Similarity NPC202470
0.9048 High Similarity NPC263092
0.9048 High Similarity NPC1755
0.9048 High Similarity NPC1706
0.9048 High Similarity NPC39305
0.9048 High Similarity NPC59295
0.9017 High Similarity NPC24258
0.9012 High Similarity NPC117450
0.8988 High Similarity NPC312056
0.8988 High Similarity NPC84515
0.8988 High Similarity NPC272722
0.8988 High Similarity NPC238995
0.8976 High Similarity NPC185526
0.8953 High Similarity NPC247964
0.8953 High Similarity NPC476370
0.8947 High Similarity NPC476279
0.8929 High Similarity NPC231758
0.8929 High Similarity NPC188486
0.892 High Similarity NPC471842
0.8916 High Similarity NPC472461
0.8916 High Similarity NPC137100
0.8902 High Similarity NPC476374
0.8902 High Similarity NPC261471
0.8895 High Similarity NPC72696
0.8895 High Similarity NPC218533
0.8895 High Similarity NPC78830
0.8889 High Similarity NPC86477
0.8889 High Similarity NPC50394
0.8857 High Similarity NPC475783
0.8844 High Similarity NPC158226
0.8837 High Similarity NPC247136
0.883 High Similarity NPC272560
0.8824 High Similarity NPC133065
0.8824 High Similarity NPC89131
0.8817 High Similarity NPC196179
0.8817 High Similarity NPC34089
0.881 High Similarity NPC196879
0.881 High Similarity NPC16935
0.881 High Similarity NPC195832
0.881 High Similarity NPC154304
0.881 High Similarity NPC190487
0.88 High Similarity NPC164384
0.8793 High Similarity NPC37606
0.8793 High Similarity NPC310794
0.8779 High Similarity NPC247973
0.8772 High Similarity NPC39306
0.8772 High Similarity NPC259757
0.8771 High Similarity NPC269625
0.8771 High Similarity NPC174486
0.8757 High Similarity NPC300680
0.8757 High Similarity NPC130955
0.8757 High Similarity NPC188967
0.875 High Similarity NPC77179
0.875 High Similarity NPC23553
0.8743 High Similarity NPC99591
0.8743 High Similarity NPC227906
0.8736 High Similarity NPC28589
0.8736 High Similarity NPC248593
0.8735 High Similarity NPC125300
0.8728 High Similarity NPC163130
0.8728 High Similarity NPC165979
0.8728 High Similarity NPC49487
0.8728 High Similarity NPC99613
0.8721 High Similarity NPC277480
0.8713 High Similarity NPC272064
0.8708 High Similarity NPC240508
0.8701 High Similarity NPC476273
0.8698 High Similarity NPC115798
0.8698 High Similarity NPC191459
0.8698 High Similarity NPC18772
0.8698 High Similarity NPC152166
0.8698 High Similarity NPC25495
0.8698 High Similarity NPC300943
0.8698 High Similarity NPC261004
0.8698 High Similarity NPC4481
0.8698 High Similarity NPC19687
0.8698 High Similarity NPC253634
0.8698 High Similarity NPC176300
0.8698 High Similarity NPC9609
0.8698 High Similarity NPC22472
0.8698 High Similarity NPC18607
0.8698 High Similarity NPC204854
0.8698 High Similarity NPC288669
0.8698 High Similarity NPC193842
0.8698 High Similarity NPC143828
0.8698 High Similarity NPC105242
0.8698 High Similarity NPC130894
0.8698 High Similarity NPC7846
0.8693 High Similarity NPC296018
0.8693 High Similarity NPC154741
0.869 High Similarity NPC45131
0.8686 High Similarity NPC233956
0.8678 High Similarity NPC28042
0.8678 High Similarity NPC476365
0.8671 High Similarity NPC234331
0.8671 High Similarity NPC76482
0.8667 High Similarity NPC47905
0.8667 High Similarity NPC73929
0.8667 High Similarity NPC139683
0.8663 High Similarity NPC169471
0.8663 High Similarity NPC291110
0.8663 High Similarity NPC37183
0.8663 High Similarity NPC280893
0.8659 High Similarity NPC476170
0.8652 High Similarity NPC97523
0.8644 High Similarity NPC221820
0.8644 High Similarity NPC476773
0.8644 High Similarity NPC246877
0.8639 High Similarity NPC472438
0.8639 High Similarity NPC78302
0.8639 High Similarity NPC75215
0.8639 High Similarity NPC29841
0.8639 High Similarity NPC110070
0.8639 High Similarity NPC235215
0.8639 High Similarity NPC224137
0.8639 High Similarity NPC305663
0.8639 High Similarity NPC7973
0.8639 High Similarity NPC112954
0.8639 High Similarity NPC176665
0.8639 High Similarity NPC227192
0.8639 High Similarity NPC163524
0.8639 High Similarity NPC189179
0.8639 High Similarity NPC203891
0.8639 High Similarity NPC93376
0.8639 High Similarity NPC287979
0.8639 High Similarity NPC101830
0.8636 High Similarity NPC289244
0.8636 High Similarity NPC245975
0.8631 High Similarity NPC292385
0.8631 High Similarity NPC80489
0.8631 High Similarity NPC125709
0.8629 High Similarity NPC47386
0.8629 High Similarity NPC262580
0.8629 High Similarity NPC212038
0.8629 High Similarity NPC81332
0.8629 High Similarity NPC271848
0.8629 High Similarity NPC289396
0.8626 High Similarity NPC60848
0.8623 High Similarity NPC27208
0.8621 High Similarity NPC41494
0.8621 High Similarity NPC186100
0.8621 High Similarity NPC216403
0.8614 High Similarity NPC260582
0.8613 High Similarity NPC29160
0.8611 High Similarity NPC304322
0.8605 High Similarity NPC67959
0.8603 High Similarity NPC246153
0.8603 High Similarity NPC228209
0.8603 High Similarity NPC36138
0.8596 High Similarity NPC112418
0.8588 High Similarity NPC156955
0.8588 High Similarity NPC472877
0.8588 High Similarity NPC107244
0.8588 High Similarity NPC268533
0.8588 High Similarity NPC36354
0.8588 High Similarity NPC216307
0.8588 High Similarity NPC287458
0.858 High Similarity NPC474520
0.858 High Similarity NPC100916
0.858 High Similarity NPC55619
0.858 High Similarity NPC247017
0.858 High Similarity NPC98661
0.858 High Similarity NPC245546
0.858 High Similarity NPC30550
0.858 High Similarity NPC265511
0.858 High Similarity NPC200388
0.858 High Similarity NPC178854
0.858 High Similarity NPC268161
0.858 High Similarity NPC266960
0.858 High Similarity NPC292107
0.858 High Similarity NPC49824
0.858 High Similarity NPC43243
0.8571 High Similarity NPC279209

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC47883 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.858 High Similarity NPD3882 Suspended
0.8547 High Similarity NPD6232 Discontinued
0.8531 High Similarity NPD4338 Clinical (unspecified phase)
0.8506 High Similarity NPD7473 Discontinued
0.8471 Intermediate Similarity NPD4868 Clinical (unspecified phase)
0.8462 Intermediate Similarity NPD2801 Approved
0.8448 Intermediate Similarity NPD6167 Clinical (unspecified phase)
0.8448 Intermediate Similarity NPD6168 Clinical (unspecified phase)
0.8448 Intermediate Similarity NPD6166 Phase 2
0.8421 Intermediate Similarity NPD3749 Approved
0.8418 Intermediate Similarity NPD7993 Clinical (unspecified phase)
0.8412 Intermediate Similarity NPD3817 Phase 2
0.8352 Intermediate Similarity NPD3818 Discontinued
0.8305 Intermediate Similarity NPD5844 Phase 1
0.8286 Intermediate Similarity NPD3926 Phase 2
0.8263 Intermediate Similarity NPD1512 Approved
0.8246 Intermediate Similarity NPD1465 Phase 2
0.8198 Intermediate Similarity NPD5402 Approved
0.8187 Intermediate Similarity NPD1934 Approved
0.8152 Intermediate Similarity NPD8397 Clinical (unspecified phase)
0.8144 Intermediate Similarity NPD1511 Approved
0.8114 Intermediate Similarity NPD5494 Approved
0.8103 Intermediate Similarity NPD7075 Discontinued
0.807 Intermediate Similarity NPD6599 Discontinued
0.8068 Intermediate Similarity NPD1247 Approved
0.8066 Intermediate Similarity NPD6559 Discontinued
0.8057 Intermediate Similarity NPD919 Approved
0.8035 Intermediate Similarity NPD2393 Clinical (unspecified phase)
0.8011 Intermediate Similarity NPD6797 Phase 2
0.7968 Intermediate Similarity NPD7879 Clinical (unspecified phase)
0.7967 Intermediate Similarity NPD7251 Discontinued
0.7966 Intermediate Similarity NPD6959 Discontinued
0.7956 Intermediate Similarity NPD7074 Phase 3
0.7933 Intermediate Similarity NPD7852 Clinical (unspecified phase)
0.7931 Intermediate Similarity NPD7096 Clinical (unspecified phase)
0.7929 Intermediate Similarity NPD6799 Approved
0.7923 Intermediate Similarity NPD7808 Phase 3
0.7901 Intermediate Similarity NPD7054 Approved
0.7874 Intermediate Similarity NPD6801 Discontinued
0.7857 Intermediate Similarity NPD7472 Approved
0.7841 Intermediate Similarity NPD7768 Phase 2
0.7816 Intermediate Similarity NPD7411 Suspended
0.7797 Intermediate Similarity NPD4381 Clinical (unspecified phase)
0.7796 Intermediate Similarity NPD8055 Clinical (unspecified phase)
0.7791 Intermediate Similarity NPD6980 Clinical (unspecified phase)
0.7791 Intermediate Similarity NPD5403 Approved
0.7778 Intermediate Similarity NPD7410 Clinical (unspecified phase)
0.7778 Intermediate Similarity NPD4378 Clinical (unspecified phase)
0.7778 Intermediate Similarity NPD7184 Clinical (unspecified phase)
0.7759 Intermediate Similarity NPD4380 Phase 2
0.7727 Intermediate Similarity NPD7819 Suspended
0.7701 Intermediate Similarity NPD3226 Approved
0.7679 Intermediate Similarity NPD2344 Approved
0.7674 Intermediate Similarity NPD5401 Approved
0.766 Intermediate Similarity NPD8434 Phase 2
0.765 Intermediate Similarity NPD3751 Discontinued
0.7647 Intermediate Similarity NPD3750 Approved
0.7609 Intermediate Similarity NPD7804 Clinical (unspecified phase)
0.7602 Intermediate Similarity NPD6190 Approved
0.7594 Intermediate Similarity NPD8312 Approved
0.7594 Intermediate Similarity NPD8313 Approved
0.7584 Intermediate Similarity NPD8443 Clinical (unspecified phase)
0.7572 Intermediate Similarity NPD2533 Approved
0.7572 Intermediate Similarity NPD2534 Approved
0.7572 Intermediate Similarity NPD2532 Approved
0.7569 Intermediate Similarity NPD7199 Phase 2
0.7563 Intermediate Similarity NPD7435 Discontinued
0.7556 Intermediate Similarity NPD6234 Discontinued
0.753 Intermediate Similarity NPD943 Approved
0.7529 Intermediate Similarity NPD1549 Phase 2
0.7527 Intermediate Similarity NPD3787 Discontinued
0.7514 Intermediate Similarity NPD7390 Discontinued
0.75 Intermediate Similarity NPD2309 Approved
0.7487 Intermediate Similarity NPD4287 Approved
0.7486 Intermediate Similarity NPD920 Approved
0.7485 Intermediate Similarity NPD1243 Approved
0.7471 Intermediate Similarity NPD1550 Clinical (unspecified phase)
0.7471 Intermediate Similarity NPD1552 Clinical (unspecified phase)
0.7471 Intermediate Similarity NPD642 Clinical (unspecified phase)
0.7456 Intermediate Similarity NPD1510 Phase 2
0.744 Intermediate Similarity NPD1607 Approved
0.7414 Intermediate Similarity NPD6143 Clinical (unspecified phase)
0.7412 Intermediate Similarity NPD2935 Discontinued
0.7412 Intermediate Similarity NPD5406 Approved
0.7412 Intermediate Similarity NPD1551 Phase 2
0.7412 Intermediate Similarity NPD5405 Approved
0.7412 Intermediate Similarity NPD5408 Approved
0.7412 Intermediate Similarity NPD5404 Approved
0.7411 Intermediate Similarity NPD6782 Approved
0.7411 Intermediate Similarity NPD6778 Approved
0.7411 Intermediate Similarity NPD6776 Approved
0.7411 Intermediate Similarity NPD6777 Approved
0.7411 Intermediate Similarity NPD6780 Approved
0.7411 Intermediate Similarity NPD6779 Approved
0.7411 Intermediate Similarity NPD6781 Approved
0.7381 Intermediate Similarity NPD447 Suspended
0.7376 Intermediate Similarity NPD8151 Discontinued
0.7374 Intermediate Similarity NPD37 Approved
0.7371 Intermediate Similarity NPD7004 Clinical (unspecified phase)
0.7366 Intermediate Similarity NPD7228 Approved
0.7356 Intermediate Similarity NPD643 Clinical (unspecified phase)
0.7353 Intermediate Similarity NPD651 Clinical (unspecified phase)
0.7353 Intermediate Similarity NPD3748 Approved
0.7348 Intermediate Similarity NPD4965 Approved
0.7348 Intermediate Similarity NPD4967 Phase 2
0.7348 Intermediate Similarity NPD4966 Approved
0.7341 Intermediate Similarity NPD4628 Phase 3
0.734 Intermediate Similarity NPD7875 Clinical (unspecified phase)
0.734 Intermediate Similarity NPD7874 Approved
0.7326 Intermediate Similarity NPD970 Clinical (unspecified phase)
0.7321 Intermediate Similarity NPD1240 Approved
0.731 Intermediate Similarity NPD2796 Approved
0.7292 Intermediate Similarity NPD8150 Discontinued
0.7283 Intermediate Similarity NPD2800 Approved
0.7283 Intermediate Similarity NPD7421 Clinical (unspecified phase)
0.7278 Intermediate Similarity NPD230 Phase 1
0.7273 Intermediate Similarity NPD7422 Clinical (unspecified phase)
0.7267 Intermediate Similarity NPD2346 Discontinued
0.7264 Intermediate Similarity NPD7870 Phase 2
0.7264 Intermediate Similarity NPD7871 Phase 2
0.7259 Intermediate Similarity NPD8090 Clinical (unspecified phase)
0.7251 Intermediate Similarity NPD1509 Clinical (unspecified phase)
0.7247 Intermediate Similarity NPD1653 Approved
0.7214 Intermediate Similarity NPD7698 Approved
0.7214 Intermediate Similarity NPD7696 Phase 3
0.7214 Intermediate Similarity NPD7697 Approved
0.7186 Intermediate Similarity NPD1529 Clinical (unspecified phase)
0.7168 Intermediate Similarity NPD1471 Phase 3
0.7158 Intermediate Similarity NPD5953 Discontinued
0.7157 Intermediate Similarity NPD6534 Approved
0.7157 Intermediate Similarity NPD6535 Approved
0.7157 Intermediate Similarity NPD7701 Phase 2
0.7151 Intermediate Similarity NPD2799 Discontinued
0.7143 Intermediate Similarity NPD6398 Clinical (unspecified phase)
0.7136 Intermediate Similarity NPD7782 Clinical (unspecified phase)
0.7136 Intermediate Similarity NPD7783 Phase 2
0.7126 Intermediate Similarity NPD1530 Clinical (unspecified phase)
0.712 Intermediate Similarity NPD7685 Pre-registration
0.7111 Intermediate Similarity NPD5808 Clinical (unspecified phase)
0.7101 Intermediate Similarity NPD2313 Discontinued
0.7101 Intermediate Similarity NPD3764 Approved
0.709 Intermediate Similarity NPD7893 Clinical (unspecified phase)
0.7075 Intermediate Similarity NPD8155 Clinical (unspecified phase)
0.7069 Intermediate Similarity NPD2343 Clinical (unspecified phase)
0.7059 Intermediate Similarity NPD6233 Phase 2
0.7059 Intermediate Similarity NPD5710 Approved
0.7059 Intermediate Similarity NPD5711 Approved
0.7059 Intermediate Similarity NPD7229 Phase 3
0.7053 Intermediate Similarity NPD7801 Approved
0.705 Intermediate Similarity NPD7700 Phase 2
0.705 Intermediate Similarity NPD7699 Phase 2
0.7049 Intermediate Similarity NPD8455 Phase 2
0.7045 Intermediate Similarity NPD1878 Clinical (unspecified phase)
0.7018 Intermediate Similarity NPD1612 Clinical (unspecified phase)
0.7018 Intermediate Similarity NPD1613 Approved
0.7017 Intermediate Similarity NPD7458 Discontinued
0.7011 Intermediate Similarity NPD6099 Approved
0.7011 Intermediate Similarity NPD6100 Approved
0.7011 Intermediate Similarity NPD2296 Approved
0.701 Intermediate Similarity NPD8320 Phase 1
0.701 Intermediate Similarity NPD8319 Approved
0.7006 Intermediate Similarity NPD1203 Approved
0.7005 Intermediate Similarity NPD8127 Discontinued
0.7 Intermediate Similarity NPD6859 Clinical (unspecified phase)
0.7 Intermediate Similarity NPD6798 Discontinued
0.7 Intermediate Similarity NPD7177 Discontinued
0.6995 Remote Similarity NPD7907 Approved
0.6989 Remote Similarity NPD5537 Clinical (unspecified phase)
0.698 Remote Similarity NPD7501 Clinical (unspecified phase)
0.6977 Remote Similarity NPD1933 Approved
0.6963 Remote Similarity NPD7286 Phase 2
0.6949 Remote Similarity NPD7003 Approved
0.6943 Remote Similarity NPD7240 Approved
0.6931 Remote Similarity NPD5242 Approved
0.6928 Remote Similarity NPD9269 Phase 2
0.6912 Remote Similarity NPD6823 Phase 2
0.6907 Remote Similarity NPD7549 Discontinued
0.6901 Remote Similarity NPD4665 Approved
0.6901 Remote Similarity NPD4111 Phase 1
0.6895 Remote Similarity NPD2403 Approved
0.6879 Remote Similarity NPD6355 Discontinued
0.6878 Remote Similarity NPD6808 Phase 2
0.6857 Remote Similarity NPD4308 Phase 3
0.6852 Remote Similarity NPD5619 Clinical (unspecified phase)
0.6842 Remote Similarity NPD7095 Approved
0.6842 Remote Similarity NPD3027 Phase 3
0.6828 Remote Similarity NPD4288 Approved
0.6823 Remote Similarity NPD2163 Approved
0.6821 Remote Similarity NPD4419 Clinical (unspecified phase)
0.6816 Remote Similarity NPD2354 Approved
0.6806 Remote Similarity NPD7784 Clinical (unspecified phase)
0.6805 Remote Similarity NPD1470 Approved
0.6802 Remote Similarity NPD411 Approved
0.6802 Remote Similarity NPD3268 Approved
0.6796 Remote Similarity NPD7680 Approved
0.6784 Remote Similarity NPD4908 Phase 1
0.6784 Remote Similarity NPD6832 Phase 2
0.678 Remote Similarity NPD2493 Approved
0.678 Remote Similarity NPD2494 Approved
0.678 Remote Similarity NPD3450 Approved

Structure

External Identifiers

PubChem CID   24178900
ChEMBL   CHEMBL251261
ZINC  

Physicochemical Properties

Molecular Weight:  460.08
ALogP:  -2.8495
MLogP:  3.22
XLogP:  3.538
# Rotatable Bonds:  10
Polar Surface Area:  160.82
# H-Bond Aceptor:  2
# H-Bond Donor:  6
# Rings:  5
# Heavy Atoms:  34

Download Data

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General Info & Identifiers & Properties  
Structure MOL file  
Source Organisms  
Biological Activities  
Similar NPs/Drugs