Natural Product: NPC477048

Natural Product ID:  NPC477048
Common Name:   Elaphopilosin E
IUPAC Name:  
Synonyms:   elaphopilosin E
Molecular Formula:   C30H40O8
Standard InCHIKey:  QGOLECXOLPTDFO-UHFFFAOYSA-N
Standard InCHI:  InChI=1S/C30H40O8/c1-7-9-10-12-21(32)24-18(26(34)22(33)16-23(24)38-6)15-19-27(35)25(20(31)11-8-2)29(37)30(5,28(19)36)14-13-17(3)4/h13,16,33-34,36-37H,7-12,14-15H2,1-6H3
Canonical SMILES:  CCCCCC(=O)c1c(OC)cc(c(c1CC1=C(O)C(C(=C(C1=O)C(=O)CCC)O)(C)CC=C(C)C)O)O
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO7440 Elaphoglossum piloselloides Species Dryopteridaceae Eukaryota La Banderita, Tucumán, Argentina PMID[20384357]

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT6698 Organism Biomphalaria peregrina Biomphalaria peregrina Activity = 81 % 20384357
NPT6698 Organism Biomphalaria peregrina Biomphalaria peregrina Activity = 52 % 20384357
NPT6698 Organism Biomphalaria peregrina Biomphalaria peregrina Activity = 14 % 20384357
NPT6698 Organism Biomphalaria peregrina Biomphalaria peregrina LD50 = 22.2 nM 20384357
NPT6698 Organism Biomphalaria peregrina Biomphalaria peregrina LD90 = 42.2 nM 20384357

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC477048 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
1.0 High Similarity NPC477047
0.9103 High Similarity NPC32694
0.9085 High Similarity NPC89474
0.9038 High Similarity NPC45146
0.9038 High Similarity NPC235018
0.9032 High Similarity NPC236796
0.9032 High Similarity NPC300727
0.9032 High Similarity NPC241904
0.9013 High Similarity NPC103509
0.8987 High Similarity NPC220313
0.8981 High Similarity NPC40491
0.8981 High Similarity NPC278052
0.8974 High Similarity NPC476242
0.8974 High Similarity NPC329091
0.8968 High Similarity NPC274730
0.8968 High Similarity NPC142339
0.8968 High Similarity NPC470762
0.8968 High Similarity NPC474167
0.8961 High Similarity NPC250557
0.8954 High Similarity NPC202157
0.8947 High Similarity NPC102003
0.8947 High Similarity NPC92722
0.8938 High Similarity NPC478060
0.8938 High Similarity NPC470377
0.8938 High Similarity NPC470374
0.8938 High Similarity NPC478059
0.8938 High Similarity NPC471975
0.8931 High Similarity NPC473286
0.8924 High Similarity NPC470694
0.8917 High Similarity NPC80375
0.8917 High Similarity NPC56085
0.8917 High Similarity NPC228785
0.8917 High Similarity NPC119224
0.8917 High Similarity NPC14353
0.8917 High Similarity NPC320359
0.8903 High Similarity NPC472048
0.8889 High Similarity NPC85131
0.8889 High Similarity NPC10467
0.8882 High Similarity NPC15329
0.8882 High Similarity NPC131451
0.8882 High Similarity NPC287395
0.8882 High Similarity NPC183655
0.8868 High Similarity NPC7483
0.8868 High Similarity NPC236132
0.8861 High Similarity NPC61010
0.8861 High Similarity NPC472275
0.8861 High Similarity NPC87431
0.8861 High Similarity NPC278427
0.8854 High Similarity NPC172770
0.8854 High Similarity NPC185258
0.8854 High Similarity NPC100123
0.8846 High Similarity NPC317383
0.8839 High Similarity NPC276409
0.8839 High Similarity NPC124714
0.8839 High Similarity NPC75279
0.8839 High Similarity NPC250822
0.8834 High Similarity NPC471969
0.8831 High Similarity NPC19980
0.8831 High Similarity NPC45291
0.8816 High Similarity NPC61871
0.8816 High Similarity NPC93034
0.8816 High Similarity NPC30647
0.8816 High Similarity NPC55557
0.8816 High Similarity NPC119660
0.8812 High Similarity NPC39306
0.88 High Similarity NPC287722
0.88 High Similarity NPC471417
0.8797 High Similarity NPC155302
0.8797 High Similarity NPC475886
0.8797 High Similarity NPC161947
0.8797 High Similarity NPC84571
0.8797 High Similarity NPC200746
0.8797 High Similarity NPC474287
0.879 High Similarity NPC469584
0.879 High Similarity NPC165977
0.879 High Similarity NPC217677
0.879 High Similarity NPC179732
0.879 High Similarity NPC79053
0.879 High Similarity NPC78103
0.8784 High Similarity NPC477055
0.8784 High Similarity NPC477056
0.8782 High Similarity NPC79998
0.8782 High Similarity NPC234485
0.8782 High Similarity NPC227325
0.8782 High Similarity NPC134287
0.8782 High Similarity NPC50715
0.8782 High Similarity NPC2476
0.8782 High Similarity NPC68727
0.8782 High Similarity NPC196439
0.8782 High Similarity NPC280339
0.8782 High Similarity NPC167815
0.8782 High Similarity NPC16082
0.8782 High Similarity NPC4455
0.8782 High Similarity NPC183597
0.8782 High Similarity NPC138360
0.8782 High Similarity NPC201136
0.8782 High Similarity NPC146165
0.8782 High Similarity NPC128863
0.8782 High Similarity NPC67396
0.8782 High Similarity NPC92659
0.8782 High Similarity NPC208197
0.8782 High Similarity NPC163780
0.8782 High Similarity NPC82592
0.8782 High Similarity NPC113906
0.8782 High Similarity NPC130589
0.8774 High Similarity NPC181209
0.8774 High Similarity NPC100263
0.8774 High Similarity NPC100971
0.8774 High Similarity NPC216769
0.8774 High Similarity NPC291802
0.8774 High Similarity NPC121522
0.8774 High Similarity NPC209487
0.8774 High Similarity NPC269451
0.8774 High Similarity NPC474993
0.8774 High Similarity NPC245382
0.8774 High Similarity NPC35763
0.8774 High Similarity NPC131266
0.8774 High Similarity NPC249570
0.8766 High Similarity NPC62042
0.8766 High Similarity NPC239363
0.8766 High Similarity NPC184136
0.8758 High Similarity NPC218490
0.8758 High Similarity NPC39091
0.875 High Similarity NPC475985
0.875 High Similarity NPC226987
0.875 High Similarity NPC138978
0.875 High Similarity NPC133065
0.875 High Similarity NPC270837
0.875 High Similarity NPC473313
0.875 High Similarity NPC143903
0.875 High Similarity NPC476822
0.875 High Similarity NPC165389
0.875 High Similarity NPC248638
0.875 High Similarity NPC329669
0.875 High Similarity NPC152659
0.875 High Similarity NPC236521
0.875 High Similarity NPC472278
0.8742 High Similarity NPC474187
0.8742 High Similarity NPC201560
0.8742 High Similarity NPC474186
0.8742 High Similarity NPC311740
0.8742 High Similarity NPC474351
0.8742 High Similarity NPC475883
0.8734 High Similarity NPC210459
0.8734 High Similarity NPC235448
0.8734 High Similarity NPC477410
0.8734 High Similarity NPC197856
0.8733 High Similarity NPC284556
0.8733 High Similarity NPC49108
0.8733 High Similarity NPC301178
0.8726 High Similarity NPC24640
0.8726 High Similarity NPC475799
0.8726 High Similarity NPC474520
0.8726 High Similarity NPC54928
0.8726 High Similarity NPC13779
0.8726 High Similarity NPC150227
0.8718 High Similarity NPC476631
0.8718 High Similarity NPC183878
0.8718 High Similarity NPC22519
0.8718 High Similarity NPC160951
0.8718 High Similarity NPC255350
0.8718 High Similarity NPC281477
0.8718 High Similarity NPC274327
0.8718 High Similarity NPC231018
0.8718 High Similarity NPC69394
0.8718 High Similarity NPC127172
0.8718 High Similarity NPC273248
0.8718 High Similarity NPC155686
0.8718 High Similarity NPC107109
0.8718 High Similarity NPC145379
0.8718 High Similarity NPC47781
0.8718 High Similarity NPC176775
0.8718 High Similarity NPC93552
0.871 High Similarity NPC262623
0.871 High Similarity NPC272566
0.8701 High Similarity NPC134293
0.8696 High Similarity NPC472450
0.8696 High Similarity NPC275780
0.8696 High Similarity NPC8070
0.8696 High Similarity NPC267153
0.8696 High Similarity NPC239752
0.8696 High Similarity NPC326520
0.8688 High Similarity NPC48860
0.8688 High Similarity NPC294965
0.8688 High Similarity NPC329760
0.8688 High Similarity NPC25152
0.8679 High Similarity NPC321399
0.8679 High Similarity NPC139036
0.8679 High Similarity NPC297212
0.8671 High Similarity NPC222814
0.8671 High Similarity NPC474208
0.8671 High Similarity NPC472963
0.8671 High Similarity NPC162869
0.8671 High Similarity NPC111969
0.8671 High Similarity NPC37543
0.8671 High Similarity NPC78302
0.8671 High Similarity NPC472914
0.8671 High Similarity NPC472438
0.8671 High Similarity NPC75215
0.8671 High Similarity NPC29841

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC477048 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.8718 High Similarity NPD2801 Approved
0.8481 Intermediate Similarity NPD2393 Clinical (unspecified phase)
0.8418 Intermediate Similarity NPD1934 Approved
0.8415 Intermediate Similarity NPD7473 Discontinued
0.8377 Intermediate Similarity NPD1511 Approved
0.8344 Intermediate Similarity NPD6232 Discontinued
0.8322 Intermediate Similarity NPD6651 Approved
0.8289 Intermediate Similarity NPD970 Clinical (unspecified phase)
0.8269 Intermediate Similarity NPD1512 Approved
0.8261 Intermediate Similarity NPD3882 Suspended
0.8235 Intermediate Similarity NPD2800 Approved
0.8133 Intermediate Similarity NPD6167 Clinical (unspecified phase)
0.8133 Intermediate Similarity NPD6168 Clinical (unspecified phase)
0.8133 Intermediate Similarity NPD6166 Phase 2
0.8092 Intermediate Similarity NPD651 Clinical (unspecified phase)
0.8089 Intermediate Similarity NPD2533 Approved
0.8089 Intermediate Similarity NPD2532 Approved
0.8089 Intermediate Similarity NPD2534 Approved
0.8067 Intermediate Similarity NPD1240 Approved
0.8067 Intermediate Similarity NPD943 Approved
0.8047 Intermediate Similarity NPD7074 Phase 3
0.8037 Intermediate Similarity NPD4868 Clinical (unspecified phase)
0.8036 Intermediate Similarity NPD3818 Discontinued
0.8025 Intermediate Similarity NPD7819 Suspended
0.7988 Intermediate Similarity NPD7054 Approved
0.7975 Intermediate Similarity NPD4378 Clinical (unspecified phase)
0.7975 Intermediate Similarity NPD3817 Phase 2
0.7974 Intermediate Similarity NPD1510 Phase 2
0.7961 Intermediate Similarity NPD1607 Approved
0.795 Intermediate Similarity NPD4380 Phase 2
0.7941 Intermediate Similarity NPD7472 Approved
0.7914 Intermediate Similarity NPD1465 Phase 2
0.7907 Intermediate Similarity NPD4338 Clinical (unspecified phase)
0.7895 Intermediate Similarity NPD230 Phase 1
0.7892 Intermediate Similarity NPD5494 Approved
0.7849 Intermediate Similarity NPD7251 Discontinued
0.7844 Intermediate Similarity NPD6959 Discontinued
0.7806 Intermediate Similarity NPD2935 Discontinued
0.7791 Intermediate Similarity NPD6797 Phase 2
0.7771 Intermediate Similarity NPD7075 Discontinued
0.7758 Intermediate Similarity NPD8443 Clinical (unspecified phase)
0.7756 Intermediate Similarity NPD1552 Clinical (unspecified phase)
0.7756 Intermediate Similarity NPD1550 Clinical (unspecified phase)
0.774 Intermediate Similarity NPD8397 Clinical (unspecified phase)
0.773 Intermediate Similarity NPD6599 Discontinued
0.7707 Intermediate Similarity NPD1549 Phase 2
0.7701 Intermediate Similarity NPD7808 Phase 3
0.7692 Intermediate Similarity NPD6099 Approved
0.7692 Intermediate Similarity NPD6100 Approved
0.7674 Intermediate Similarity NPD5844 Phase 1
0.7665 Intermediate Similarity NPD4381 Clinical (unspecified phase)
0.7647 Intermediate Similarity NPD3926 Phase 2
0.764 Intermediate Similarity NPD7410 Clinical (unspecified phase)
0.7628 Intermediate Similarity NPD1509 Clinical (unspecified phase)
0.761 Intermediate Similarity NPD3750 Approved
0.759 Intermediate Similarity NPD7096 Clinical (unspecified phase)
0.7586 Intermediate Similarity NPD7993 Clinical (unspecified phase)
0.758 Intermediate Similarity NPD2796 Approved
0.7578 Intermediate Similarity NPD6799 Approved
0.7578 Intermediate Similarity NPD7390 Discontinued
0.7545 Intermediate Similarity NPD5402 Approved
0.7529 Intermediate Similarity NPD1247 Approved
0.7515 Intermediate Similarity NPD6234 Discontinued
0.75 Intermediate Similarity NPD6398 Clinical (unspecified phase)
0.75 Intermediate Similarity NPD1878 Clinical (unspecified phase)
0.7485 Intermediate Similarity NPD5710 Approved
0.7485 Intermediate Similarity NPD5711 Approved
0.7471 Intermediate Similarity NPD7804 Clinical (unspecified phase)
0.747 Intermediate Similarity NPD7411 Suspended
0.7459 Intermediate Similarity NPD7879 Clinical (unspecified phase)
0.7456 Intermediate Similarity NPD3749 Approved
0.7439 Intermediate Similarity NPD6980 Clinical (unspecified phase)
0.7425 Intermediate Similarity NPD6801 Discontinued
0.7425 Intermediate Similarity NPD37 Approved
0.7423 Intermediate Similarity NPD7422 Clinical (unspecified phase)
0.7403 Intermediate Similarity NPD3027 Phase 3
0.74 Intermediate Similarity NPD9269 Phase 2
0.7386 Intermediate Similarity NPD9494 Approved
0.7349 Intermediate Similarity NPD3226 Approved
0.7325 Intermediate Similarity NPD447 Suspended
0.7314 Intermediate Similarity NPD7228 Approved
0.7312 Intermediate Similarity NPD2344 Approved
0.7299 Intermediate Similarity NPD7852 Clinical (unspecified phase)
0.7296 Intermediate Similarity NPD3748 Approved
0.7294 Intermediate Similarity NPD7768 Phase 2
0.7294 Intermediate Similarity NPD4967 Phase 2
0.7294 Intermediate Similarity NPD4966 Approved
0.7294 Intermediate Similarity NPD4965 Approved
0.7284 Intermediate Similarity NPD4628 Phase 3
0.7278 Intermediate Similarity NPD8055 Clinical (unspecified phase)
0.7273 Intermediate Similarity NPD7501 Clinical (unspecified phase)
0.7273 Intermediate Similarity NPD1530 Clinical (unspecified phase)
0.7247 Intermediate Similarity NPD6559 Discontinued
0.7244 Intermediate Similarity NPD6859 Clinical (unspecified phase)
0.7238 Intermediate Similarity NPD8434 Phase 2
0.7237 Intermediate Similarity NPD4379 Clinical (unspecified phase)
0.7226 Intermediate Similarity NPD1529 Clinical (unspecified phase)
0.7225 Intermediate Similarity NPD7199 Phase 2
0.7222 Intermediate Similarity NPD2654 Approved
0.7216 Intermediate Similarity NPD3751 Discontinued
0.7209 Intermediate Similarity NPD919 Approved
0.7208 Intermediate Similarity NPD6917 Clinical (unspecified phase)
0.7171 Intermediate Similarity NPD3972 Approved
0.7152 Intermediate Similarity NPD1612 Clinical (unspecified phase)
0.7152 Intermediate Similarity NPD1613 Approved
0.7143 Intermediate Similarity NPD7184 Clinical (unspecified phase)
0.7143 Intermediate Similarity NPD1551 Phase 2
0.7143 Intermediate Similarity NPD8150 Discontinued
0.7134 Intermediate Similarity NPD2309 Approved
0.7134 Intermediate Similarity NPD6190 Approved
0.7133 Intermediate Similarity NPD9268 Approved
0.7126 Intermediate Similarity NPD920 Approved
0.7126 Intermediate Similarity NPD5403 Approved
0.7117 Intermediate Similarity NPD1243 Approved
0.7102 Intermediate Similarity NPD2403 Approved
0.7099 Intermediate Similarity NPD2346 Discontinued
0.7095 Intermediate Similarity NPD5953 Discontinued
0.709 Intermediate Similarity NPD6779 Approved
0.709 Intermediate Similarity NPD6782 Approved
0.709 Intermediate Similarity NPD6781 Approved
0.709 Intermediate Similarity NPD6777 Approved
0.709 Intermediate Similarity NPD6778 Approved
0.709 Intermediate Similarity NPD6780 Approved
0.709 Intermediate Similarity NPD6776 Approved
0.7086 Intermediate Similarity NPD3787 Discontinued
0.7083 Intermediate Similarity NPD1653 Approved
0.7081 Intermediate Similarity NPD2799 Discontinued
0.7079 Intermediate Similarity NPD7286 Phase 2
0.7073 Intermediate Similarity NPD8166 Discontinued
0.7068 Intermediate Similarity NPD7435 Discontinued
0.7062 Intermediate Similarity NPD8151 Discontinued
0.7048 Intermediate Similarity NPD6143 Clinical (unspecified phase)
0.7047 Intermediate Similarity NPD405 Clinical (unspecified phase)
0.7035 Intermediate Similarity NPD5353 Approved
0.7032 Intermediate Similarity NPD1470 Approved
0.7025 Intermediate Similarity NPD6410 Clinical (unspecified phase)
0.7012 Intermediate Similarity NPD7421 Clinical (unspecified phase)
0.7006 Intermediate Similarity NPD5401 Approved
0.7006 Intermediate Similarity NPD642 Clinical (unspecified phase)
0.6993 Remote Similarity NPD1201 Approved
0.6988 Remote Similarity NPD3300 Phase 2
0.6987 Remote Similarity NPD2798 Approved
0.6979 Remote Similarity NPD7697 Approved
0.6979 Remote Similarity NPD7696 Phase 3
0.6979 Remote Similarity NPD7698 Approved
0.6978 Remote Similarity NPD8313 Approved
0.6978 Remote Similarity NPD8312 Approved
0.6961 Remote Similarity NPD3658 Clinical (unspecified phase)
0.6961 Remote Similarity NPD7685 Pre-registration
0.6949 Remote Similarity NPD5242 Approved
0.6943 Remote Similarity NPD7870 Phase 2
0.6943 Remote Similarity NPD7871 Phase 2
0.6941 Remote Similarity NPD7458 Discontinued
0.6931 Remote Similarity NPD7907 Approved
0.6927 Remote Similarity NPD6823 Phase 2
0.6923 Remote Similarity NPD4419 Clinical (unspecified phase)
0.6923 Remote Similarity NPD7701 Phase 2
0.6903 Remote Similarity NPD4749 Approved
0.6899 Remote Similarity NPD6832 Phase 2
0.6893 Remote Similarity NPD7229 Phase 3
0.6886 Remote Similarity NPD643 Clinical (unspecified phase)
0.6868 Remote Similarity NPD7240 Approved
0.6867 Remote Similarity NPD7003 Approved
0.6859 Remote Similarity NPD1876 Approved
0.6859 Remote Similarity NPD6696 Suspended
0.6853 Remote Similarity NPD7874 Approved
0.6853 Remote Similarity NPD7875 Clinical (unspecified phase)
0.6839 Remote Similarity NPD9717 Approved
0.6835 Remote Similarity NPD3018 Phase 2
0.6829 Remote Similarity NPD5406 Approved
0.6829 Remote Similarity NPD5408 Approved
0.6829 Remote Similarity NPD5405 Approved
0.6829 Remote Similarity NPD5404 Approved
0.6825 Remote Similarity NPD6534 Approved
0.6825 Remote Similarity NPD6535 Approved
0.6821 Remote Similarity NPD9493 Approved
0.6818 Remote Similarity NPD7801 Approved
0.6818 Remote Similarity NPD7783 Phase 2
0.6818 Remote Similarity NPD7782 Clinical (unspecified phase)
0.6815 Remote Similarity NPD1203 Approved
0.6813 Remote Similarity NPD2313 Discontinued
0.6813 Remote Similarity NPD3764 Approved
0.6806 Remote Similarity NPD7699 Phase 2
0.6806 Remote Similarity NPD7700 Phase 2
0.6805 Remote Similarity NPD7004 Clinical (unspecified phase)
0.6797 Remote Similarity NPD4196 Clinical (unspecified phase)
0.6793 Remote Similarity NPD3534 Clinical (unspecified phase)
0.6792 Remote Similarity NPD4908 Phase 1
0.6788 Remote Similarity NPD1471 Phase 3
0.6782 Remote Similarity NPD5760 Phase 2
0.6782 Remote Similarity NPD5761 Phase 2
0.6776 Remote Similarity NPD5536 Phase 2
0.6776 Remote Similarity NPD6104 Discontinued
0.6774 Remote Similarity NPD422 Phase 1
0.6763 Remote Similarity NPD5089 Approved
0.6763 Remote Similarity NPD6386 Approved
0.6763 Remote Similarity NPD6385 Approved
0.6763 Remote Similarity NPD5090 Approved
0.6757 Remote Similarity NPD7090 Clinical (unspecified phase)
0.6753 Remote Similarity NPD4626 Approved

Structure

External Identifiers

PubChem CID  
ChEMBL   CHEMBL1099116
ZINC  

Physicochemical Properties

Molecular Weight:  528.27
ALogP:  -0.7196
MLogP:  3.88
XLogP:  4.94
# Rotatable Bonds:  23
Polar Surface Area:  141.36
# H-Bond Aceptor:  5
# H-Bond Donor:  4
# Rings:  2
# Heavy Atoms:  38

Download Data

Data Type Select
General Info & Identifiers & Properties  
Structure MOL file  
Source Organisms  
Biological Activities  
Similar NPs/Drugs