Natural Product: NPC476531

Natural Product ID:  NPC476531
Common Name:   Siphonodictyal B1
IUPAC Name:  
Synonyms:   Siphonodictyal B1
Molecular Formula:   C24H35NO9S2
Standard InCHIKey:  FHQITOIUGPNWFK-ULCRCHNNSA-N
Standard InCHI:  InChI=1S/C24H35NO9S2/c1-15-6-7-20-23(2,3)8-5-9-24(20,4)18(15)12-16-13-19(26)21(27)17(22(16)34-36(31,32)33)14-25-10-11-35(28,29)30/h12-15,20,26-27H,5-11H2,1-4H3,(H,28,29,30)(H,31,32,33)/b18-12+,25-14+/t15-,20?,24+/m0/s1
Canonical SMILES:  C[C@H]1CCC2[C@](/C/1=C/c1cc(O)c(c(c1OS(=O)(=O)O)/C=N/CCS(=O)(=O)O)O)(C)CCCC2(C)C
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO9771 Aka coralliphagum Species Niphatidae Eukaryota San Salvador in the Bahamas (12-26 m depth) 2001-MAR; 2003-JUL PMID[17309298]

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT2 Others Unspecified Activity = 80.8 % 17309298
NPT2 Others Unspecified Activity = 23.5 % 17309298
NPT19 Organism Escherichia coli Escherichia coli IZ = 0 mm 17309298
NPT173 Organism Klebsiella pneumoniae Klebsiella pneumoniae IZ = 0 mm 17309298
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa IZ = 0 mm 17309298
NPT729 Organism Micrococcus luteus Micrococcus luteus IZ = 0 mm 17309298
NPT1177 Organism Mycobacterium phlei Mycobacterium phlei IZ = 0 mm 17309298
NPT16 Organism Staphylococcus aureus Staphylococcus aureus IZ = 12 mm 17309298
NPT20 Organism Candida albicans Candida albicans IZ = 0 mm 17309298
NPT772 Organism Pichia anomala Wickerhamomyces anomalus IZ = 0 mm 17309298
NPT312 Organism Saccharomyces cerevisiae Saccharomyces cerevisiae IZ = 0 mm 17309298
NPT87 Organism Aspergillus fumigatus Aspergillus fumigatus IZ = 0 mm 17309298
NPT635 Organism Botryotinia fuckeliana Botryotinia fuckeliana IZ = 13 mm 17309298
NPT2701 Organism Pythium debaryanum Pythium debaryanum IZ = 0 mm 17309298
NPT1460 Cell Line L929 Mus musculus Activity = 10 ug/ml 17309298

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC476531 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.7852 Intermediate Similarity NPC476536
0.7584 Intermediate Similarity NPC53567
0.7533 Intermediate Similarity NPC224342
0.753 Intermediate Similarity NPC476533
0.745 Intermediate Similarity NPC237667
0.741 Intermediate Similarity NPC476532
0.7383 Intermediate Similarity NPC24125
0.7365 Intermediate Similarity NPC191866
0.7347 Intermediate Similarity NPC277588
0.7333 Intermediate Similarity NPC39029
0.7305 Intermediate Similarity NPC474191
0.7297 Intermediate Similarity NPC206
0.7256 Intermediate Similarity NPC90645
0.7248 Intermediate Similarity NPC217174
0.723 Intermediate Similarity NPC16030
0.7215 Intermediate Similarity NPC474453
0.72 Intermediate Similarity NPC475245
0.7181 Intermediate Similarity NPC144343
0.7171 Intermediate Similarity NPC471794
0.7169 Intermediate Similarity NPC476535
0.7162 Intermediate Similarity NPC141001
0.7152 Intermediate Similarity NPC472457
0.7143 Intermediate Similarity NPC127402
0.7133 Intermediate Similarity NPC323074
0.7099 Intermediate Similarity NPC6300
0.7099 Intermediate Similarity NPC230124
0.7099 Intermediate Similarity NPC29868
0.7099 Intermediate Similarity NPC212942
0.7099 Intermediate Similarity NPC79622
0.7099 Intermediate Similarity NPC114171
0.7089 Intermediate Similarity NPC312341
0.7086 Intermediate Similarity NPC325544
0.7086 Intermediate Similarity NPC318581
0.7086 Intermediate Similarity NPC477037
0.7073 Intermediate Similarity NPC175838
0.7055 Intermediate Similarity NPC295719
0.7055 Intermediate Similarity NPC34431
0.7055 Intermediate Similarity NPC266650
0.7055 Intermediate Similarity NPC73505
0.7055 Intermediate Similarity NPC165026
0.7041 Intermediate Similarity NPC195561
0.7039 Intermediate Similarity NPC284078
0.7019 Intermediate Similarity NPC313081
0.7018 Intermediate Similarity NPC107602
0.7006 Intermediate Similarity NPC112251
0.7 Intermediate Similarity NPC2745
0.6994 Remote Similarity NPC184613
0.6988 Remote Similarity NPC473845
0.6981 Remote Similarity NPC15543
0.6981 Remote Similarity NPC232275
0.698 Remote Similarity NPC472893
0.698 Remote Similarity NPC84999
0.698 Remote Similarity NPC246760
0.6975 Remote Similarity NPC476639
0.6975 Remote Similarity NPC143139
0.6975 Remote Similarity NPC205442
0.6975 Remote Similarity NPC114155
0.6975 Remote Similarity NPC300846
0.6975 Remote Similarity NPC202846
0.6974 Remote Similarity NPC472071
0.697 Remote Similarity NPC323126
0.6959 Remote Similarity NPC157783
0.6959 Remote Similarity NPC317869
0.6959 Remote Similarity NPC263753
0.6957 Remote Similarity NPC125649
0.6957 Remote Similarity NPC209199
0.6951 Remote Similarity NPC308768
0.6951 Remote Similarity NPC259519
0.6951 Remote Similarity NPC12668
0.6951 Remote Similarity NPC198038
0.6951 Remote Similarity NPC234568
0.6946 Remote Similarity NPC292256
0.6941 Remote Similarity NPC158784
0.6939 Remote Similarity NPC77772
0.6937 Remote Similarity NPC6451
0.6937 Remote Similarity NPC14224
0.6937 Remote Similarity NPC161958
0.6933 Remote Similarity NPC115808
0.6933 Remote Similarity NPC56329
0.6933 Remote Similarity NPC90615
0.6933 Remote Similarity NPC201145
0.6933 Remote Similarity NPC73535
0.6933 Remote Similarity NPC242715
0.6933 Remote Similarity NPC22902
0.6933 Remote Similarity NPC272157
0.6933 Remote Similarity NPC6262
0.6933 Remote Similarity NPC25111
0.6923 Remote Similarity NPC33654
0.6923 Remote Similarity NPC212142
0.6914 Remote Similarity NPC10314
0.6914 Remote Similarity NPC108198
0.6914 Remote Similarity NPC241241
0.6914 Remote Similarity NPC200557
0.6914 Remote Similarity NPC69029
0.6914 Remote Similarity NPC294884
0.6914 Remote Similarity NPC158142
0.6913 Remote Similarity NPC107240
0.6913 Remote Similarity NPC471534
0.6909 Remote Similarity NPC35216
0.6908 Remote Similarity NPC176893
0.6908 Remote Similarity NPC469644
0.6908 Remote Similarity NPC268572
0.6905 Remote Similarity NPC475896
0.6903 Remote Similarity NPC318777
0.6901 Remote Similarity NPC48949
0.6901 Remote Similarity NPC302915
0.6893 Remote Similarity NPC90984
0.6892 Remote Similarity NPC177962
0.6892 Remote Similarity NPC43525
0.6892 Remote Similarity NPC471179
0.6892 Remote Similarity NPC62867
0.689 Remote Similarity NPC220344
0.689 Remote Similarity NPC19869
0.689 Remote Similarity NPC243996
0.689 Remote Similarity NPC218131
0.689 Remote Similarity NPC132804
0.689 Remote Similarity NPC105847
0.689 Remote Similarity NPC243759
0.689 Remote Similarity NPC275061
0.6887 Remote Similarity NPC304510
0.6887 Remote Similarity NPC172219
0.6887 Remote Similarity NPC470760
0.6886 Remote Similarity NPC5462
0.6886 Remote Similarity NPC50250
0.6886 Remote Similarity NPC63879
0.6875 Remote Similarity NPC12275
0.6875 Remote Similarity NPC45715
0.6875 Remote Similarity NPC474356
0.6871 Remote Similarity NPC30632
0.6871 Remote Similarity NPC68292
0.6864 Remote Similarity NPC262297
0.6863 Remote Similarity NPC223451
0.6863 Remote Similarity NPC69006
0.686 Remote Similarity NPC325860
0.6852 Remote Similarity NPC160697
0.6852 Remote Similarity NPC293454
0.6848 Remote Similarity NPC61783
0.6848 Remote Similarity NPC20520
0.6846 Remote Similarity NPC117846
0.6846 Remote Similarity NPC23804
0.6842 Remote Similarity NPC469609
0.6842 Remote Similarity NPC471671
0.6842 Remote Similarity NPC122009
0.6839 Remote Similarity NPC195766
0.6839 Remote Similarity NPC206736
0.6835 Remote Similarity NPC252131
0.6835 Remote Similarity NPC471077
0.6835 Remote Similarity NPC477839
0.6833 Remote Similarity NPC231371
0.6832 Remote Similarity NPC59239
0.6832 Remote Similarity NPC218884
0.6829 Remote Similarity NPC200935
0.6829 Remote Similarity NPC151656
0.6829 Remote Similarity NPC266006
0.6829 Remote Similarity NPC230919
0.6829 Remote Similarity NPC266453
0.6829 Remote Similarity NPC296898
0.6826 Remote Similarity NPC85264
0.6826 Remote Similarity NPC47633
0.6826 Remote Similarity NPC102044
0.6824 Remote Similarity NPC4493
0.6824 Remote Similarity NPC266937
0.6824 Remote Similarity NPC225679
0.6824 Remote Similarity NPC165770
0.6824 Remote Similarity NPC268032
0.6824 Remote Similarity NPC176279
0.6824 Remote Similarity NPC470770
0.6824 Remote Similarity NPC260323
0.6824 Remote Similarity NPC476632
0.6821 Remote Similarity NPC471668
0.6813 Remote Similarity NPC311680
0.6813 Remote Similarity NPC234488
0.6813 Remote Similarity NPC224157
0.6813 Remote Similarity NPC299221
0.6813 Remote Similarity NPC51840
0.6813 Remote Similarity NPC99795
0.6813 Remote Similarity NPC192687
0.681 Remote Similarity NPC283009
0.681 Remote Similarity NPC261873
0.681 Remote Similarity NPC111655
0.6807 Remote Similarity NPC476534
0.6807 Remote Similarity NPC265075
0.6807 Remote Similarity NPC71046
0.6805 Remote Similarity NPC260397
0.6802 Remote Similarity NPC275027
0.6796 Remote Similarity NPC474051
0.6792 Remote Similarity NPC28765
0.6792 Remote Similarity NPC201069
0.679 Remote Similarity NPC227719
0.6788 Remote Similarity NPC70682
0.6788 Remote Similarity NPC25966
0.6788 Remote Similarity NPC32630
0.6788 Remote Similarity NPC260741
0.6788 Remote Similarity NPC127218
0.6788 Remote Similarity NPC319647
0.6788 Remote Similarity NPC245207
0.6786 Remote Similarity NPC93323
0.6786 Remote Similarity NPC12641
0.6786 Remote Similarity NPC280092
0.6786 Remote Similarity NPC45257

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC476531 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.6818 Remote Similarity NPD3143 Discontinued
0.6797 Remote Similarity NPD4235 Clinical (unspecified phase)
0.6748 Remote Similarity NPD4097 Suspended
0.6711 Remote Similarity NPD7325 Clinical (unspecified phase)
0.6689 Remote Similarity NPD3022 Approved
0.6689 Remote Similarity NPD4750 Phase 3
0.6689 Remote Similarity NPD3021 Approved
0.6608 Remote Similarity NPD4160 Clinical (unspecified phase)
0.6604 Remote Similarity NPD4339 Clinical (unspecified phase)
0.6604 Remote Similarity NPD3094 Phase 2
0.6591 Remote Similarity NPD5929 Approved
0.6556 Remote Similarity NPD7635 Approved
0.6552 Remote Similarity NPD4005 Discontinued
0.6533 Remote Similarity NPD9280 Clinical (unspecified phase)
0.6524 Remote Similarity NPD1555 Discontinued
0.6522 Remote Similarity NPD1530 Clinical (unspecified phase)
0.6497 Remote Similarity NPD7089 Clinical (unspecified phase)
0.6481 Remote Similarity NPD1529 Clinical (unspecified phase)
0.648 Remote Similarity NPD7975 Clinical (unspecified phase)
0.6474 Remote Similarity NPD4093 Discontinued
0.6471 Remote Similarity NPD475 Phase 2
0.6467 Remote Similarity NPD7743 Approved
0.6467 Remote Similarity NPD7742 Approved
0.6456 Remote Similarity NPD3092 Approved
0.6453 Remote Similarity NPD2420 Approved
0.6453 Remote Similarity NPD2421 Approved
0.6442 Remote Similarity NPD3027 Phase 3
0.6433 Remote Similarity NPD1751 Approved
0.6433 Remote Similarity NPD3095 Discontinued
0.6416 Remote Similarity NPD3645 Discontinued
0.6415 Remote Similarity NPD2337 Clinical (unspecified phase)
0.6415 Remote Similarity NPD3070 Discontinued
0.6391 Remote Similarity NPD2029 Clinical (unspecified phase)
0.6391 Remote Similarity NPD3540 Phase 1
0.638 Remote Similarity NPD2606 Approved
0.638 Remote Similarity NPD2605 Approved
0.6358 Remote Similarity NPD6917 Clinical (unspecified phase)
0.6341 Remote Similarity NPD5155 Approved
0.6341 Remote Similarity NPD5156 Approved
0.6339 Remote Similarity NPD7229 Phase 3
0.6337 Remote Similarity NPD2219 Phase 1
0.6331 Remote Similarity NPD3539 Phase 1
0.6327 Remote Similarity NPD940 Approved
0.6327 Remote Similarity NPD846 Approved
0.6325 Remote Similarity NPD1613 Approved
0.6325 Remote Similarity NPD3620 Phase 2
0.6325 Remote Similarity NPD3619 Clinical (unspecified phase)
0.6325 Remote Similarity NPD6346 Approved
0.6325 Remote Similarity NPD1612 Clinical (unspecified phase)
0.6325 Remote Similarity NPD468 Phase 1
0.6322 Remote Similarity NPD7422 Clinical (unspecified phase)
0.6319 Remote Similarity NPD3636 Approved
0.6319 Remote Similarity NPD3637 Approved
0.6319 Remote Similarity NPD3635 Approved
0.6316 Remote Similarity NPD5698 Clinical (unspecified phase)
0.6306 Remote Similarity NPD3091 Approved
0.6303 Remote Similarity NPD2028 Clinical (unspecified phase)
0.6303 Remote Similarity NPD6410 Clinical (unspecified phase)
0.6303 Remote Similarity NPD4907 Clinical (unspecified phase)
0.6302 Remote Similarity NPD7906 Approved
0.6301 Remote Similarity NPD3300 Phase 2
0.6294 Remote Similarity NPD4721 Approved
0.6294 Remote Similarity NPD4725 Approved
0.6294 Remote Similarity NPD4726 Approved
0.6292 Remote Similarity NPD7438 Suspended
0.6292 Remote Similarity NPD7615 Clinical (unspecified phase)
0.6289 Remote Similarity NPD3023 Approved
0.6289 Remote Similarity NPD3026 Approved
0.628 Remote Similarity NPD3595 Approved
0.628 Remote Similarity NPD3594 Approved
0.6279 Remote Similarity NPD3892 Phase 2
0.6278 Remote Similarity NPD7494 Clinical (unspecified phase)
0.6278 Remote Similarity NPD7738 Approved
0.6278 Remote Similarity NPD7737 Approved
0.6264 Remote Similarity NPD7390 Discontinued
0.6264 Remote Similarity NPD6234 Discontinued
0.6259 Remote Similarity NPD289 Clinical (unspecified phase)
0.625 Remote Similarity NPD1792 Phase 2
0.625 Remote Similarity NPD5351 Clinical (unspecified phase)
0.625 Remote Similarity NPD5314 Approved
0.625 Remote Similarity NPD5350 Clinical (unspecified phase)
0.6242 Remote Similarity NPD4625 Phase 3
0.6236 Remote Similarity NPD4675 Approved
0.6236 Remote Similarity NPD4678 Approved
0.6235 Remote Similarity NPD5311 Approved
0.6235 Remote Similarity NPD5310 Approved
0.6235 Remote Similarity NPD1632 Clinical (unspecified phase)
0.6235 Remote Similarity NPD2922 Phase 1
0.6228 Remote Similarity NPD3061 Approved
0.6228 Remote Similarity NPD3059 Approved
0.6228 Remote Similarity NPD3062 Approved
0.6226 Remote Similarity NPD3019 Approved
0.6226 Remote Similarity NPD4059 Approved
0.6218 Remote Similarity NPD6843 Phase 3
0.6218 Remote Similarity NPD6841 Approved
0.6218 Remote Similarity NPD6842 Approved
0.6213 Remote Similarity NPD3554 Approved
0.6213 Remote Similarity NPD3552 Approved
0.6213 Remote Similarity NPD3553 Approved
0.6213 Remote Similarity NPD6111 Discontinued
0.6213 Remote Similarity NPD3555 Approved
0.6211 Remote Similarity NPD5032 Approved
0.6209 Remote Similarity NPD4055 Discovery
0.6207 Remote Similarity NPD7124 Phase 2
0.6203 Remote Similarity NPD5304 Approved
0.6203 Remote Similarity NPD5303 Approved
0.6196 Remote Similarity NPD3053 Approved
0.6196 Remote Similarity NPD3055 Approved
0.6194 Remote Similarity NPD2229 Approved
0.6194 Remote Similarity NPD2234 Approved
0.6194 Remote Similarity NPD2228 Approved
0.6193 Remote Similarity NPD5261 Clinical (unspecified phase)
0.619 Remote Similarity NPD3657 Discovery
0.6185 Remote Similarity NPD6331 Phase 2
0.6185 Remote Similarity NPD8166 Discontinued
0.6185 Remote Similarity NPD3400 Discontinued
0.6182 Remote Similarity NPD4908 Phase 1
0.6178 Remote Similarity NPD5035 Approved
0.6176 Remote Similarity NPD1509 Clinical (unspecified phase)
0.6173 Remote Similarity NPD4749 Approved
0.6168 Remote Similarity NPD2674 Phase 3
0.6168 Remote Similarity NPD6405 Approved
0.6168 Remote Similarity NPD6407 Approved
0.6167 Remote Similarity NPD37 Approved
0.6166 Remote Similarity NPD4663 Approved
0.6164 Remote Similarity NPD3024 Approved
0.6164 Remote Similarity NPD3025 Approved
0.6159 Remote Similarity NPD2195 Approved
0.6159 Remote Similarity NPD2194 Approved
0.6154 Remote Similarity NPD2568 Approved
0.615 Remote Similarity NPD7473 Discontinued
0.6149 Remote Similarity NPD1242 Phase 1
0.6149 Remote Similarity NPD302 Approved
0.6146 Remote Similarity NPD7090 Clinical (unspecified phase)
0.6141 Remote Similarity NPD6746 Phase 2
0.614 Remote Similarity NPD6099 Approved
0.614 Remote Similarity NPD6100 Approved
0.6135 Remote Similarity NPD6696 Suspended
0.6131 Remote Similarity NPD943 Approved
0.6131 Remote Similarity NPD2238 Phase 2
0.6129 Remote Similarity NPD6332 Clinical (unspecified phase)
0.6129 Remote Similarity NPD9377 Approved
0.6129 Remote Similarity NPD9379 Approved
0.6125 Remote Similarity NPD9384 Approved
0.6125 Remote Similarity NPD9381 Approved
0.6125 Remote Similarity NPD2286 Discontinued
0.6125 Remote Similarity NPD2932 Approved
0.6118 Remote Similarity NPD2342 Discontinued
0.6117 Remote Similarity NPD7493 Clinical (unspecified phase)
0.6117 Remote Similarity NPD7228 Approved
0.6114 Remote Similarity NPD2422 Clinical (unspecified phase)
0.6114 Remote Similarity NPD3845 Phase 1
0.6111 Remote Similarity NPD5090 Approved
0.6111 Remote Similarity NPD3796 Clinical (unspecified phase)
0.6111 Remote Similarity NPD5089 Approved
0.6111 Remote Similarity NPD6072 Discontinued
0.6108 Remote Similarity NPD3145 Approved
0.6108 Remote Similarity NPD3144 Approved
0.6101 Remote Similarity NPD7330 Discontinued
0.6099 Remote Similarity NPD6374 Clinical (unspecified phase)
0.6096 Remote Similarity NPD2489 Approved
0.6096 Remote Similarity NPD1809 Phase 2
0.6096 Remote Similarity NPD27 Approved
0.6094 Remote Similarity NPD7310 Approved
0.6094 Remote Similarity NPD4577 Approved
0.6094 Remote Similarity NPD7313 Approved
0.6094 Remote Similarity NPD7312 Approved
0.6094 Remote Similarity NPD4578 Approved
0.6094 Remote Similarity NPD7311 Approved
0.6082 Remote Similarity NPD4108 Discontinued
0.6081 Remote Similarity NPD3020 Approved
0.608 Remote Similarity NPD4357 Discontinued
0.6075 Remote Similarity NPD6232 Discontinued
0.6074 Remote Similarity NPD1669 Approved
0.6074 Remote Similarity NPD9622 Approved
0.6069 Remote Similarity NPD4256 Phase 2
0.6069 Remote Similarity NPD4257 Approved
0.6066 Remote Similarity NPD4967 Phase 2
0.6066 Remote Similarity NPD4965 Approved
0.6066 Remote Similarity NPD4966 Approved
0.6062 Remote Similarity NPD8053 Approved
0.6062 Remote Similarity NPD8054 Approved
0.6062 Remote Similarity NPD7309 Approved
0.6061 Remote Similarity NPD9621 Approved
0.6061 Remote Similarity NPD9620 Approved
0.6061 Remote Similarity NPD7451 Discontinued
0.6061 Remote Similarity NPD9619 Approved
0.6059 Remote Similarity NPD2157 Approved
0.6057 Remote Similarity NPD7910 Clinical (unspecified phase)
0.6053 Remote Similarity NPD1445 Approved
0.6053 Remote Similarity NPD1444 Approved
0.6045 Remote Similarity NPD7447 Phase 1
0.6044 Remote Similarity NPD2393 Clinical (unspecified phase)
0.6042 Remote Similarity NPD7549 Discontinued
0.6042 Remote Similarity NPD8453 Clinical (unspecified phase)
0.6036 Remote Similarity NPD1558 Phase 1
0.6036 Remote Similarity NPD5837 Clinical (unspecified phase)
0.6034 Remote Similarity NPD6674 Discontinued
0.6034 Remote Similarity NPD2209 Approved
0.6034 Remote Similarity NPD3638 Discontinued

Structure

External Identifiers

PubChem CID  
ChEMBL   CHEMBL222633
ZINC  

Physicochemical Properties

Molecular Weight:  545.18
ALogP:  -0.3973
MLogP:  2.78
XLogP:  4.05
# Rotatable Bonds:  15
Polar Surface Area:  187.55
# H-Bond Aceptor:  7
# H-Bond Donor:  4
# Rings:  3
# Heavy Atoms:  36

Download Data

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General Info & Identifiers & Properties  
Structure MOL file  
Source Organisms  
Biological Activities  
Similar NPs/Drugs