Natural Product: NPC475689

Natural Product ID:  NPC475689
Common Name:   Uvidin B
IUPAC Name:   (1aR,2aR,4S,6aR,7S,7aR)-4-hydroxy-7-(hydroxymethyl)-3,3,6a,7a-tetramethyl-1a,2a,4,5,6,7-hexahydronaphtho[2,3-b]oxiren-2-one
Synonyms:  
Molecular Formula:   C15H24O4
Standard InCHIKey:  YPCORLCLAAQRFS-ZZHPKZEWSA-N
Standard InCHI:  InChI=1S/C15H24O4/c1-13(2)9(17)5-6-14(3)8(7-16)15(4)12(19-15)10(18)11(13)14/h8-9,11-12,16-17H,5-7H2,1-4H3/t8-,9+,11+,12+,14-,15-/m1/s1
Canonical SMILES:  OC[C@@H]1[C@@]2(C)CC[C@@H](C([C@@H]2C(=O)[C@H]2[C@]1(C)O2)(C)C)O
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO14206 Lactarius uvidus Species Russulaceae Eukaryota PMID[7964786]

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT116 Cell Line HL-60 Homo sapiens Inhibition = 0 % PubChem BioAssay data set
NPT116 Cell Line HL-60 Homo sapiens Inhibition = 61 % 22037378

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC475689 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.9359 High Similarity NPC275243
0.8987 High Similarity NPC475725
0.8824 High Similarity NPC226491
0.8824 High Similarity NPC477614
0.881 High Similarity NPC475729
0.881 High Similarity NPC474215
0.8764 High Similarity NPC477264
0.8621 High Similarity NPC477433
0.8621 High Similarity NPC477442
0.8621 High Similarity NPC477444
0.8506 High Similarity NPC477443
0.8506 High Similarity NPC477440
0.8452 Intermediate Similarity NPC227170
0.837 Intermediate Similarity NPC476294
0.8353 Intermediate Similarity NPC477434
0.8242 Intermediate Similarity NPC17336
0.8182 Intermediate Similarity NPC236459
0.8161 Intermediate Similarity NPC477441
0.809 Intermediate Similarity NPC61688
0.8065 Intermediate Similarity NPC111187
0.8065 Intermediate Similarity NPC190080
0.8046 Intermediate Similarity NPC477205
0.8046 Intermediate Similarity NPC473350
0.8046 Intermediate Similarity NPC477445
0.8043 Intermediate Similarity NPC62407
0.8043 Intermediate Similarity NPC287354
0.8023 Intermediate Similarity NPC15091
0.8022 Intermediate Similarity NPC474379
0.7978 Intermediate Similarity NPC163296
0.7955 Intermediate Similarity NPC248216
0.7955 Intermediate Similarity NPC120395
0.7955 Intermediate Similarity NPC83242
0.7952 Intermediate Similarity NPC143250
0.7931 Intermediate Similarity NPC237938
0.7931 Intermediate Similarity NPC219535
0.7931 Intermediate Similarity NPC50438
0.7912 Intermediate Similarity NPC216137
0.7889 Intermediate Similarity NPC67653
0.7889 Intermediate Similarity NPC471459
0.7865 Intermediate Similarity NPC470920
0.7857 Intermediate Similarity NPC478084
0.7831 Intermediate Similarity NPC474020
0.7826 Intermediate Similarity NPC476189
0.7802 Intermediate Similarity NPC475211
0.7802 Intermediate Similarity NPC88337
0.7791 Intermediate Similarity NPC475743
0.7778 Intermediate Similarity NPC471221
0.7778 Intermediate Similarity NPC90676
0.7778 Intermediate Similarity NPC131104
0.7778 Intermediate Similarity NPC473319
0.7778 Intermediate Similarity NPC3032
0.7742 Intermediate Similarity NPC309127
0.7742 Intermediate Similarity NPC247877
0.7738 Intermediate Similarity NPC307865
0.7727 Intermediate Similarity NPC25037
0.7727 Intermediate Similarity NPC34984
0.7727 Intermediate Similarity NPC105895
0.7692 Intermediate Similarity NPC200580
0.7667 Intermediate Similarity NPC263802
0.7614 Intermediate Similarity NPC327451
0.7609 Intermediate Similarity NPC476296
0.7604 Intermediate Similarity NPC253995
0.7586 Intermediate Similarity NPC254123
0.7582 Intermediate Similarity NPC476379
0.7579 Intermediate Similarity NPC235109
0.7579 Intermediate Similarity NPC163685
0.7579 Intermediate Similarity NPC193785
0.7576 Intermediate Similarity NPC88469
0.7556 Intermediate Similarity NPC476717
0.7556 Intermediate Similarity NPC476727
0.7556 Intermediate Similarity NPC476726
0.7528 Intermediate Similarity NPC471044
0.7528 Intermediate Similarity NPC473336
0.7528 Intermediate Similarity NPC473299
0.75 Intermediate Similarity NPC472984
0.75 Intermediate Similarity NPC159789
0.75 Intermediate Similarity NPC477266
0.75 Intermediate Similarity NPC271163
0.7474 Intermediate Similarity NPC82633
0.7473 Intermediate Similarity NPC202937
0.7471 Intermediate Similarity NPC125366
0.7471 Intermediate Similarity NPC134227
0.747 Intermediate Similarity NPC474755
0.7449 Intermediate Similarity NPC259654
0.7449 Intermediate Similarity NPC112613
0.7449 Intermediate Similarity NPC298266
0.7426 Intermediate Similarity NPC201908
0.7426 Intermediate Similarity NPC176949
0.7423 Intermediate Similarity NPC474724
0.7416 Intermediate Similarity NPC472847
0.7396 Intermediate Similarity NPC260223
0.7396 Intermediate Similarity NPC476728
0.7391 Intermediate Similarity NPC476435
0.7386 Intermediate Similarity NPC328639
0.7386 Intermediate Similarity NPC50658
0.7386 Intermediate Similarity NPC329490
0.7381 Intermediate Similarity NPC317212
0.7381 Intermediate Similarity NPC55508
0.7379 Intermediate Similarity NPC100908
0.7374 Intermediate Similarity NPC471254
0.7374 Intermediate Similarity NPC478176
0.7368 Intermediate Similarity NPC217567
0.7368 Intermediate Similarity NPC76136
0.7368 Intermediate Similarity NPC329713
0.7368 Intermediate Similarity NPC470424
0.7363 Intermediate Similarity NPC80700
0.7363 Intermediate Similarity NPC302111
0.7353 Intermediate Similarity NPC289702
0.7353 Intermediate Similarity NPC208461
0.7353 Intermediate Similarity NPC153587
0.734 Intermediate Similarity NPC475878
0.734 Intermediate Similarity NPC52756
0.7333 Intermediate Similarity NPC181871
0.7333 Intermediate Similarity NPC9060
0.7333 Intermediate Similarity NPC79308
0.7333 Intermediate Similarity NPC65133
0.7327 Intermediate Similarity NPC470587
0.7312 Intermediate Similarity NPC56962
0.7312 Intermediate Similarity NPC24705
0.7308 Intermediate Similarity NPC157476
0.7308 Intermediate Similarity NPC473062
0.73 Intermediate Similarity NPC471253
0.73 Intermediate Similarity NPC266
0.73 Intermediate Similarity NPC469985
0.73 Intermediate Similarity NPC34562
0.7294 Intermediate Similarity NPC68565
0.7294 Intermediate Similarity NPC472950
0.7294 Intermediate Similarity NPC35871
0.7294 Intermediate Similarity NPC472952
0.7292 Intermediate Similarity NPC470031
0.7292 Intermediate Similarity NPC305808
0.7284 Intermediate Similarity NPC329466
0.7284 Intermediate Similarity NPC328304
0.7283 Intermediate Similarity NPC239938
0.7282 Intermediate Similarity NPC87335
0.7282 Intermediate Similarity NPC204652
0.7282 Intermediate Similarity NPC16657
0.7273 Intermediate Similarity NPC475958
0.7273 Intermediate Similarity NPC46848
0.7273 Intermediate Similarity NPC207885
0.7273 Intermediate Similarity NPC14634
0.7273 Intermediate Similarity NPC472943
0.7273 Intermediate Similarity NPC472951
0.7264 Intermediate Similarity NPC470115
0.7264 Intermediate Similarity NPC470116
0.7263 Intermediate Similarity NPC147272
0.7253 Intermediate Similarity NPC474572
0.7245 Intermediate Similarity NPC471038
0.7245 Intermediate Similarity NPC477653
0.7245 Intermediate Similarity NPC474793
0.7234 Intermediate Similarity NPC77756
0.7228 Intermediate Similarity NPC327093
0.7222 Intermediate Similarity NPC269684
0.7216 Intermediate Similarity NPC116683
0.7216 Intermediate Similarity NPC94337
0.7216 Intermediate Similarity NPC219353
0.7216 Intermediate Similarity NPC165616
0.7209 Intermediate Similarity NPC472486
0.7209 Intermediate Similarity NPC472487
0.7204 Intermediate Similarity NPC191221
0.72 Intermediate Similarity NPC275990
0.72 Intermediate Similarity NPC470172
0.7191 Intermediate Similarity NPC469745
0.7191 Intermediate Similarity NPC476071
0.7188 Intermediate Similarity NPC477495
0.7184 Intermediate Similarity NPC316930
0.7174 Intermediate Similarity NPC243746
0.7174 Intermediate Similarity NPC472745
0.7172 Intermediate Similarity NPC293890
0.7158 Intermediate Similarity NPC474699
0.7158 Intermediate Similarity NPC198054
0.7158 Intermediate Similarity NPC474065
0.7157 Intermediate Similarity NPC50535
0.7143 Intermediate Similarity NPC471916
0.7143 Intermediate Similarity NPC74466
0.7143 Intermediate Similarity NPC474996
0.7143 Intermediate Similarity NPC96322
0.7143 Intermediate Similarity NPC207689
0.7143 Intermediate Similarity NPC89310
0.7143 Intermediate Similarity NPC470632
0.7143 Intermediate Similarity NPC319909
0.7143 Intermediate Similarity NPC470281
0.7129 Intermediate Similarity NPC139347
0.7129 Intermediate Similarity NPC107385
0.7129 Intermediate Similarity NPC131366
0.7129 Intermediate Similarity NPC87927
0.7129 Intermediate Similarity NPC473406
0.7129 Intermediate Similarity NPC96217
0.7126 Intermediate Similarity NPC475031
0.7115 Intermediate Similarity NPC321661
0.7115 Intermediate Similarity NPC320475
0.7113 Intermediate Similarity NPC231060
0.7113 Intermediate Similarity NPC41070
0.7113 Intermediate Similarity NPC217329
0.7113 Intermediate Similarity NPC477437
0.7113 Intermediate Similarity NPC477438
0.7113 Intermediate Similarity NPC138245
0.7113 Intermediate Similarity NPC470232
0.7113 Intermediate Similarity NPC84018
0.7111 Intermediate Similarity NPC328007

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC475689 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.7629 Intermediate Similarity NPD1700 Approved
0.75 Intermediate Similarity NPD3703 Phase 2
0.7353 Intermediate Similarity NPD5345 Clinical (unspecified phase)
0.6905 Remote Similarity NPD3700 Clinical (unspecified phase)
0.6905 Remote Similarity NPD3699 Clinical (unspecified phase)
0.6854 Remote Similarity NPD6115 Approved
0.6854 Remote Similarity NPD6697 Approved
0.6854 Remote Similarity NPD6118 Approved
0.6854 Remote Similarity NPD6114 Approved
0.6744 Remote Similarity NPD4808 Clinical (unspecified phase)
0.6744 Remote Similarity NPD4809 Clinical (unspecified phase)
0.6742 Remote Similarity NPD6116 Phase 1
0.6667 Remote Similarity NPD7128 Approved
0.6667 Remote Similarity NPD5739 Approved
0.6667 Remote Similarity NPD6675 Approved
0.6667 Remote Similarity NPD8295 Clinical (unspecified phase)
0.6667 Remote Similarity NPD6402 Approved
0.6637 Remote Similarity NPD6059 Approved
0.6637 Remote Similarity NPD6319 Approved
0.6637 Remote Similarity NPD6054 Approved
0.6636 Remote Similarity NPD6372 Approved
0.6636 Remote Similarity NPD6373 Approved
0.6634 Remote Similarity NPD4755 Approved
0.6629 Remote Similarity NPD6117 Approved
0.6628 Remote Similarity NPD4789 Approved
0.6627 Remote Similarity NPD3171 Clinical (unspecified phase)
0.6604 Remote Similarity NPD5701 Approved
0.6604 Remote Similarity NPD5697 Approved
0.6579 Remote Similarity NPD6016 Approved
0.6579 Remote Similarity NPD6015 Approved
0.6579 Remote Similarity NPD6921 Approved
0.6574 Remote Similarity NPD4634 Approved
0.6542 Remote Similarity NPD6899 Approved
0.6542 Remote Similarity NPD7320 Approved
0.6542 Remote Similarity NPD6881 Approved
0.6522 Remote Similarity NPD6370 Approved
0.6522 Remote Similarity NPD5988 Approved
0.6514 Remote Similarity NPD6649 Approved
0.6514 Remote Similarity NPD6650 Approved
0.6512 Remote Similarity NPD3698 Phase 2
0.6505 Remote Similarity NPD5285 Approved
0.6505 Remote Similarity NPD5286 Approved
0.6505 Remote Similarity NPD4700 Approved
0.6505 Remote Similarity NPD4696 Approved
0.6481 Remote Similarity NPD6013 Approved
0.6481 Remote Similarity NPD6012 Approved
0.6481 Remote Similarity NPD6014 Approved
0.6466 Remote Similarity NPD8328 Phase 3
0.6437 Remote Similarity NPD4245 Approved
0.6437 Remote Similarity NPD4244 Approved
0.6422 Remote Similarity NPD6883 Approved
0.6422 Remote Similarity NPD7290 Approved
0.6422 Remote Similarity NPD7102 Approved
0.6415 Remote Similarity NPD8170 Clinical (unspecified phase)
0.641 Remote Similarity NPD7492 Approved
0.6404 Remote Similarity NPD6113 Clinical (unspecified phase)
0.6395 Remote Similarity NPD5360 Phase 3
0.6395 Remote Similarity NPD5361 Clinical (unspecified phase)
0.6389 Remote Similarity NPD6011 Approved
0.6381 Remote Similarity NPD5225 Approved
0.6381 Remote Similarity NPD4633 Approved
0.6381 Remote Similarity NPD5226 Approved
0.6381 Remote Similarity NPD5211 Phase 2
0.6381 Remote Similarity NPD5224 Approved
0.6373 Remote Similarity NPD4697 Phase 3
0.6364 Remote Similarity NPD6869 Approved
0.6364 Remote Similarity NPD6847 Approved
0.6364 Remote Similarity NPD8130 Phase 1
0.6364 Remote Similarity NPD6617 Approved
0.6356 Remote Similarity NPD6616 Approved
0.6355 Remote Similarity NPD6008 Approved
0.6333 Remote Similarity NPD3702 Approved
0.633 Remote Similarity NPD4061 Clinical (unspecified phase)
0.6321 Remote Similarity NPD5175 Approved
0.6321 Remote Similarity NPD5174 Approved
0.631 Remote Similarity NPD371 Approved
0.6306 Remote Similarity NPD8297 Approved
0.6306 Remote Similarity NPD6882 Approved
0.6304 Remote Similarity NPD3671 Phase 1
0.6303 Remote Similarity NPD7078 Approved
0.6303 Remote Similarity NPD8293 Discontinued
0.6286 Remote Similarity NPD5223 Approved
0.6277 Remote Similarity NPD1780 Approved
0.6277 Remote Similarity NPD1779 Approved
0.6273 Remote Similarity NPD5955 Clinical (unspecified phase)
0.6262 Remote Similarity NPD5141 Approved
0.625 Remote Similarity NPD4632 Approved
0.625 Remote Similarity NPD7736 Approved
0.6228 Remote Similarity NPD6009 Approved
0.6216 Remote Similarity NPD6401 Clinical (unspecified phase)
0.6214 Remote Similarity NPD5221 Approved
0.6214 Remote Similarity NPD5220 Clinical (unspecified phase)
0.6214 Remote Similarity NPD5222 Approved
0.6204 Remote Similarity NPD4768 Approved
0.6204 Remote Similarity NPD4767 Approved
0.6186 Remote Similarity NPD7604 Phase 2
0.6182 Remote Similarity NPD8132 Clinical (unspecified phase)
0.618 Remote Similarity NPD4758 Discontinued
0.6176 Remote Similarity NPD5282 Discontinued
0.6168 Remote Similarity NPD4754 Approved
0.6154 Remote Similarity NPD5173 Approved
0.6154 Remote Similarity NPD5983 Phase 2
0.614 Remote Similarity NPD6274 Approved
0.6139 Remote Similarity NPD8035 Phase 2
0.6139 Remote Similarity NPD8034 Phase 2
0.6136 Remote Similarity NPD4267 Clinical (unspecified phase)
0.6122 Remote Similarity NPD3618 Phase 1
0.6116 Remote Similarity NPD6033 Approved
0.61 Remote Similarity NPD5328 Approved
0.6091 Remote Similarity NPD4729 Approved
0.6091 Remote Similarity NPD5128 Approved
0.6091 Remote Similarity NPD4730 Approved
0.6023 Remote Similarity NPD229 Approved
0.6 Remote Similarity NPD5954 Clinical (unspecified phase)
0.6 Remote Similarity NPD5777 Approved
0.6 Remote Similarity NPD6083 Phase 2
0.6 Remote Similarity NPD6084 Phase 2
0.6 Remote Similarity NPD7902 Approved
0.5983 Remote Similarity NPD7101 Approved
0.5983 Remote Similarity NPD7100 Approved
0.5982 Remote Similarity NPD5251 Approved
0.5982 Remote Similarity NPD5247 Approved
0.5982 Remote Similarity NPD5248 Approved
0.5982 Remote Similarity NPD5249 Phase 3
0.5982 Remote Similarity NPD5250 Approved
0.598 Remote Similarity NPD6079 Approved
0.5979 Remote Similarity NPD3670 Clinical (unspecified phase)
0.5979 Remote Similarity NPD3669 Approved
0.5977 Remote Similarity NPD4224 Phase 2
0.5963 Remote Similarity NPD4056 Clinical (unspecified phase)
0.5963 Remote Similarity NPD4057 Clinical (unspecified phase)
0.596 Remote Similarity NPD3574 Clinical (unspecified phase)
0.5957 Remote Similarity NPD5364 Discontinued
0.595 Remote Similarity NPD6336 Discontinued
0.5948 Remote Similarity NPD7115 Discovery
0.5948 Remote Similarity NPD6317 Approved
0.5943 Remote Similarity NPD5696 Approved
0.5941 Remote Similarity NPD4753 Phase 2
0.5929 Remote Similarity NPD5217 Approved
0.5929 Remote Similarity NPD5216 Approved
0.5929 Remote Similarity NPD5215 Approved
0.5922 Remote Similarity NPD4202 Approved
0.5922 Remote Similarity NPD6399 Phase 3
0.5897 Remote Similarity NPD6313 Approved
0.5897 Remote Similarity NPD6335 Approved
0.5897 Remote Similarity NPD6314 Approved
0.5882 Remote Similarity NPD6909 Approved
0.5882 Remote Similarity NPD6908 Approved
0.5876 Remote Similarity NPD3667 Approved
0.587 Remote Similarity NPD1810 Approved
0.587 Remote Similarity NPD1811 Approved
0.5865 Remote Similarity NPD7748 Approved
0.5859 Remote Similarity NPD7520 Clinical (unspecified phase)
0.5841 Remote Similarity NPD5169 Approved
0.5841 Remote Similarity NPD5135 Approved
0.5841 Remote Similarity NPD5134 Clinical (unspecified phase)
0.5833 Remote Similarity NPD6928 Phase 2
0.5825 Remote Similarity NPD7515 Phase 2
0.5825 Remote Similarity NPD6411 Approved
0.5824 Remote Similarity NPD6081 Approved
0.581 Remote Similarity NPD5210 Approved
0.581 Remote Similarity NPD5695 Phase 3
0.581 Remote Similarity NPD4629 Approved
0.5794 Remote Similarity NPD7638 Approved
0.5789 Remote Similarity NPD4802 Phase 2
0.5789 Remote Similarity NPD5127 Approved
0.5789 Remote Similarity NPD4238 Approved
0.5769 Remote Similarity NPD5778 Approved
0.5769 Remote Similarity NPD5779 Approved
0.5758 Remote Similarity NPD4786 Approved
0.575 Remote Similarity NPD6291 Clinical (unspecified phase)
0.5741 Remote Similarity NPD7640 Approved
0.5741 Remote Similarity NPD7639 Approved
0.5726 Remote Similarity NPD6868 Approved
0.5714 Remote Similarity NPD7901 Clinical (unspecified phase)
0.5714 Remote Similarity NPD6412 Phase 2
0.5714 Remote Similarity NPD7900 Approved
0.569 Remote Similarity NPD8133 Approved
0.5682 Remote Similarity NPD9496 Clinical (unspecified phase)
0.568 Remote Similarity NPD7319 Approved
0.5664 Remote Similarity NPD5168 Approved
0.5657 Remote Similarity NPD4788 Approved
0.5648 Remote Similarity NPD4225 Approved
0.5641 Remote Similarity NPD5167 Approved
0.5636 Remote Similarity NPD7632 Discontinued
0.5636 Remote Similarity NPD8083 Approved
0.5636 Remote Similarity NPD8084 Approved
0.5636 Remote Similarity NPD8301 Approved
0.5636 Remote Similarity NPD8138 Approved
0.5636 Remote Similarity NPD8082 Approved
0.5636 Remote Similarity NPD8300 Approved
0.5636 Remote Similarity NPD8086 Approved
0.5636 Remote Similarity NPD8085 Approved
0.5636 Remote Similarity NPD8139 Approved
0.5631 Remote Similarity NPD5764 Clinical (unspecified phase)
0.5631 Remote Similarity NPD6101 Approved
0.5625 Remote Similarity NPD3617 Approved
0.561 Remote Similarity NPD615 Clinical (unspecified phase)
0.56 Remote Similarity NPD3666 Approved
0.56 Remote Similarity NPD3133 Approved

Structure

External Identifiers

PubChem CID   44559676
ChEMBL   CHEMBL511683
ZINC  

Physicochemical Properties

Molecular Weight:  268.17
ALogP:  -0.8698
MLogP:  2.67
XLogP:  0.749
# Rotatable Bonds:  7
Polar Surface Area:  70.06
# H-Bond Aceptor:  4
# H-Bond Donor:  2
# Rings:  3
# Heavy Atoms:  19

Download Data

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General Info & Identifiers & Properties  
Structure MOL file  
Source Organisms  
Biological Activities  
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