Similar Natural Products in NPASS
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient 
● The left chart: Distribution of similarity level between NPC317825 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.56 or Top200).
| range |
Tanimoto Coefficient |
| 0-0.1 | 26277 |
| 0.1-0.2 | 4351 |
| 0.2-0.3 | 216 |
| 0.3-0.4 | 26 |
| 0.4-0.5 | 11 |
| 0.5-0.6 | 8 |
| 0.6-0.7 | 0 |
| 0.7-0.8 | 0 |
| 0.8-0.85 | 0 |
| 0.85-0.9 | 0 |
| 0.9-0.95 | 0 |
| 0.95-1 | 0 |
| Similarity Score |
Similarity Level |
Natural Product ID |
| 0.5833
|
Remote Similarity |
NPC317545 |
Similar Clinical/Approved Drugs
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.
● The left chart: Distribution of similarity level between NPC317825 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).
| range |
Tanimoto Coefficient |
| 0-0.1 | 8171 |
| 0.1-0.2 | 830 |
| 0.2-0.3 | 109 |
| 0.3-0.4 | 24 |
| 0.4-0.5 | 13 |
| 0.5-0.6 | 10 |
| 0.6-0.7 | 4 |
| 0.7-0.8 | 0 |
| 0.8-0.85 | 0 |
| 0.85-0.9 | 0 |
| 0.9-0.95 | 0 |
| 0.95-1 | 0 |
| Similarity Score |
Similarity Level |
Drug ID |
Developmental Stage |
| 0.6842 |
Remote Similarity |
NPD9771 |
Approved |
| 0.6818 |
Remote Similarity |
NPD8559 |
Clinical (unspecified phase) |
| 0.6471 |
Remote Similarity |
NPD9770 |
Approved |
| 0.6 |
Remote Similarity |
NPD9732 |
Approved |
| 0.5909 |
Remote Similarity |
NPD7384 |
Approved |
| 0.5652 |
Remote Similarity |
NPD7385 |
Approved |
| 0.56 |
Remote Similarity |
NPD8220 |
Approved |
| 0.56
|
Remote Similarity |
NPD8219 |
Approved |
