Natural Product: NPC311092

Natural Product ID:  NPC311092
Common Name:   Ganoderiol F
IUPAC Name:   (5R,10S,13R,14R,17R)-17-[(2R)-7-hydroxy-6-(hydroxymethyl)hept-5-en-2-yl]-4,4,10,13,14-pentamethyl-1,2,5,6,12,15,16,17-octahydrocyclopenta[a]phenanthren-3-one
Synonyms:   Ganoderiol F
Molecular Formula:   C30H46O3
Standard InCHIKey:  JVGJXXNUVVQEIG-MCKXIFHVSA-N
Standard InCHI:  InChI=1S/C30H46O3/c1-20(8-7-9-21(18-31)19-32)22-12-16-30(6)24-10-11-25-27(2,3)26(33)14-15-28(25,4)23(24)13-17-29(22,30)5/h9-10,13,20,22,25,31-32H,7-8,11-12,14-19H2,1-6H3/t20-,22-,25+,28-,29-,30+/m1/s1
Canonical SMILES:  OCC(=CCC[C@H]([C@H]1CC[C@@]2([C@]1(C)CC=C1C2=CC[C@@H]2[C@]1(C)CCC(=O)C2(C)C)C)C)CO
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO25269 Ganoderma lucidum Species Ganodermataceae Eukaryota fruiting bodies PMID[21924611]
NPO33020 ganoderma leucocontextum Species Ganodermataceae Eukaryota fruiting bodies Tibet, China PMID[26287401]
NPO29588 Ganoderma Genus Ganodermataceae Eukaryota TCMSP*
NPO25269 Ganoderma lucidum Species Ganodermataceae Eukaryota TM-MC*
NPO16609 Ganoderma sinense Species Ganodermataceae Eukaryota TM-MC*

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT204 Individual Protein Acetylcholinesterase Homo sapiens IC50 = 21840 nM 21924611
NPT439 Individual Protein Butyrylcholinesterase Homo sapiens IC50 > 200000 nM 21924611
NPT2 Others Unspecified EC50 = 5000 nM 22014750
NPT2 Others Unspecified IC50 = 2 ug/ml 23092389
NPT2 Others Unspecified IC50 = 10.1 ug/ml 23092389
NPT165 Cell Line HeLa Homo sapiens IC50 = 5000 nM 23092389
NPT1317 Cell Line CCRF S-180 Mus musculus IC50 = 7.1 ug/ml 23092389
NPT396 Cell Line T47D Homo sapiens IC50 = 3 ug/ml 23092389
NPT1044 Individual Protein DNA topoisomerase II alpha Homo sapiens IC50 = 17000 nM 23092389
NPT143 Individual Protein DNA topoisomerase I Homo sapiens IC50 = 106000 nM 23092389
NPT2 Others Unspecified IC50 = 25300 nM 23092389
NPT1229 Cell Line Huh-7 Homo sapiens IC50 = 8500 nM 23092389
NPT65 Cell Line HepG2 Homo sapiens IC50 = 17000 nM 23092389
NPT111 Cell Line K562 Homo sapiens IC50 = 4000 nM 23092389
NPT113 Cell Line RAW264.7 Mus musculus IC50 = 36000 nM 23357630
NPT2 Others Unspecified Ratio IC50 = 3 24070782
NPT2 Others Unspecified IC50 = 207800 nM 24070782
NPT516 Individual Protein TNF-alpha Homo sapiens Kd = 16.8 nM 24974349
NPT65 Cell Line HepG2 Homo sapiens IC50 = 20700 nM 24974349
NPT1088 Individual Protein 3-hydroxy-3-methylglutaryl-coenzyme A reductase Sus scrofa IC50 > 100000 nM 26287401
NPT2 Others Unspecified IC50 > 50000 nM 26287401
NPT111 Cell Line K562 Homo sapiens IC50 = 54900 nM 26287401
NPT306 Cell Line PC-3 Homo sapiens IC50 = 79500 nM 26287401

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC311092 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.9868 High Similarity NPC4166
0.9136 High Similarity NPC472931
0.9136 High Similarity NPC472940
0.9125 High Similarity NPC41539
0.8902 High Similarity NPC474083
0.8837 High Similarity NPC472942
0.8824 High Similarity NPC69622
0.878 High Similarity NPC87552
0.8734 High Similarity NPC82635
0.8675 High Similarity NPC471224
0.8537 High Similarity NPC142253
0.8537 High Similarity NPC3511
0.8409 Intermediate Similarity NPC472930
0.8395 Intermediate Similarity NPC170793
0.8375 Intermediate Similarity NPC91665
0.8372 Intermediate Similarity NPC44181
0.8353 Intermediate Similarity NPC469994
0.8353 Intermediate Similarity NPC89077
0.8333 Intermediate Similarity NPC473246
0.8315 Intermediate Similarity NPC469406
0.8313 Intermediate Similarity NPC472239
0.8276 Intermediate Similarity NPC2983
0.8276 Intermediate Similarity NPC309603
0.8276 Intermediate Similarity NPC473999
0.8256 Intermediate Similarity NPC136548
0.8256 Intermediate Similarity NPC287079
0.8235 Intermediate Similarity NPC470048
0.8235 Intermediate Similarity NPC8571
0.8222 Intermediate Similarity NPC472932
0.8214 Intermediate Similarity NPC83569
0.8214 Intermediate Similarity NPC69279
0.8205 Intermediate Similarity NPC470078
0.8202 Intermediate Similarity NPC69454
0.8182 Intermediate Similarity NPC48010
0.8171 Intermediate Similarity NPC472490
0.8152 Intermediate Similarity NPC166745
0.8152 Intermediate Similarity NPC235464
0.814 Intermediate Similarity NPC222613
0.814 Intermediate Similarity NPC475022
0.814 Intermediate Similarity NPC118648
0.814 Intermediate Similarity NPC473168
0.8132 Intermediate Similarity NPC155676
0.8118 Intermediate Similarity NPC221758
0.8118 Intermediate Similarity NPC59453
0.8118 Intermediate Similarity NPC82902
0.8118 Intermediate Similarity NPC165064
0.8118 Intermediate Similarity NPC214043
0.8118 Intermediate Similarity NPC85774
0.8095 Intermediate Similarity NPC472867
0.809 Intermediate Similarity NPC473998
0.809 Intermediate Similarity NPC233116
0.809 Intermediate Similarity NPC475806
0.809 Intermediate Similarity NPC63748
0.809 Intermediate Similarity NPC23217
0.8072 Intermediate Similarity NPC472478
0.8068 Intermediate Similarity NPC84271
0.8068 Intermediate Similarity NPC102414
0.8068 Intermediate Similarity NPC77168
0.8052 Intermediate Similarity NPC20610
0.8049 Intermediate Similarity NPC470052
0.8046 Intermediate Similarity NPC317590
0.8046 Intermediate Similarity NPC476293
0.8046 Intermediate Similarity NPC90652
0.8023 Intermediate Similarity NPC469948
0.8023 Intermediate Similarity NPC474218
0.8022 Intermediate Similarity NPC259286
0.8 Intermediate Similarity NPC279639
0.8 Intermediate Similarity NPC152897
0.8 Intermediate Similarity NPC474736
0.8 Intermediate Similarity NPC3856
0.8 Intermediate Similarity NPC250575
0.8 Intermediate Similarity NPC470384
0.8 Intermediate Similarity NPC66429
0.7978 Intermediate Similarity NPC320026
0.7978 Intermediate Similarity NPC129913
0.7976 Intermediate Similarity NPC201912
0.7976 Intermediate Similarity NPC6663
0.7976 Intermediate Similarity NPC38350
0.7957 Intermediate Similarity NPC471717
0.7957 Intermediate Similarity NPC48647
0.7957 Intermediate Similarity NPC103051
0.7955 Intermediate Similarity NPC470417
0.7955 Intermediate Similarity NPC471722
0.7952 Intermediate Similarity NPC90965
0.7949 Intermediate Similarity NPC182815
0.7935 Intermediate Similarity NPC472941
0.7935 Intermediate Similarity NPC456
0.7935 Intermediate Similarity NPC249954
0.7931 Intermediate Similarity NPC31564
0.7931 Intermediate Similarity NPC474733
0.7931 Intermediate Similarity NPC72133
0.7931 Intermediate Similarity NPC94755
0.7931 Intermediate Similarity NPC474778
0.7931 Intermediate Similarity NPC145879
0.7931 Intermediate Similarity NPC474732
0.7931 Intermediate Similarity NPC51014
0.7912 Intermediate Similarity NPC474690
0.7912 Intermediate Similarity NPC8993
0.7907 Intermediate Similarity NPC181743
0.7907 Intermediate Similarity NPC16287
0.7907 Intermediate Similarity NPC237712
0.7907 Intermediate Similarity NPC178025
0.7889 Intermediate Similarity NPC19114
0.7889 Intermediate Similarity NPC204341
0.7882 Intermediate Similarity NPC260956
0.7882 Intermediate Similarity NPC151519
0.7882 Intermediate Similarity NPC202389
0.7882 Intermediate Similarity NPC469804
0.7882 Intermediate Similarity NPC469799
0.7882 Intermediate Similarity NPC469806
0.7882 Intermediate Similarity NPC469805
0.7875 Intermediate Similarity NPC474228
0.7875 Intermediate Similarity NPC303613
0.7875 Intermediate Similarity NPC470045
0.7875 Intermediate Similarity NPC470044
0.7865 Intermediate Similarity NPC1015
0.7865 Intermediate Similarity NPC86319
0.7865 Intermediate Similarity NPC214387
0.7865 Intermediate Similarity NPC123912
0.7865 Intermediate Similarity NPC31985
0.7865 Intermediate Similarity NPC472971
0.7865 Intermediate Similarity NPC275740
0.7865 Intermediate Similarity NPC472970
0.7848 Intermediate Similarity NPC159577
0.7848 Intermediate Similarity NPC282593
0.7848 Intermediate Similarity NPC35734
0.7848 Intermediate Similarity NPC307176
0.7841 Intermediate Similarity NPC159046
0.7841 Intermediate Similarity NPC187376
0.7841 Intermediate Similarity NPC475740
0.7841 Intermediate Similarity NPC96496
0.7841 Intermediate Similarity NPC58063
0.7841 Intermediate Similarity NPC233836
0.7841 Intermediate Similarity NPC93778
0.7831 Intermediate Similarity NPC297996
0.7826 Intermediate Similarity NPC469995
0.7826 Intermediate Similarity NPC318282
0.7826 Intermediate Similarity NPC263347
0.7826 Intermediate Similarity NPC127063
0.7826 Intermediate Similarity NPC174948
0.7826 Intermediate Similarity NPC271195
0.7826 Intermediate Similarity NPC180950
0.7826 Intermediate Similarity NPC173875
0.7816 Intermediate Similarity NPC274724
0.7816 Intermediate Similarity NPC60350
0.7802 Intermediate Similarity NPC243866
0.7802 Intermediate Similarity NPC477520
0.7791 Intermediate Similarity NPC470046
0.7791 Intermediate Similarity NPC310470
0.7791 Intermediate Similarity NPC476082
0.7791 Intermediate Similarity NPC278648
0.7791 Intermediate Similarity NPC470047
0.7789 Intermediate Similarity NPC99411
0.7778 Intermediate Similarity NPC469400
0.7778 Intermediate Similarity NPC191684
0.7778 Intermediate Similarity NPC477147
0.7778 Intermediate Similarity NPC171441
0.7778 Intermediate Similarity NPC477149
0.7766 Intermediate Similarity NPC186810
0.7766 Intermediate Similarity NPC197386
0.7765 Intermediate Similarity NPC103754
0.7765 Intermediate Similarity NPC121984
0.7765 Intermediate Similarity NPC147066
0.7765 Intermediate Similarity NPC474484
0.7753 Intermediate Similarity NPC310752
0.7753 Intermediate Similarity NPC143767
0.7753 Intermediate Similarity NPC131470
0.7753 Intermediate Similarity NPC328313
0.7753 Intermediate Similarity NPC471724
0.7753 Intermediate Similarity NPC292491
0.775 Intermediate Similarity NPC115023
0.775 Intermediate Similarity NPC181204
0.7742 Intermediate Similarity NPC328371
0.7742 Intermediate Similarity NPC78473
0.7738 Intermediate Similarity NPC474113
0.7738 Intermediate Similarity NPC477371
0.7738 Intermediate Similarity NPC215843
0.7727 Intermediate Similarity NPC28252
0.7727 Intermediate Similarity NPC155011
0.7727 Intermediate Similarity NPC55309
0.7727 Intermediate Similarity NPC470955
0.7722 Intermediate Similarity NPC139397
0.7717 Intermediate Similarity NPC292793
0.7717 Intermediate Similarity NPC209662
0.7717 Intermediate Similarity NPC299100
0.7717 Intermediate Similarity NPC473162
0.7711 Intermediate Similarity NPC74995
0.7711 Intermediate Similarity NPC325946
0.7711 Intermediate Similarity NPC470557
0.7701 Intermediate Similarity NPC231310
0.7701 Intermediate Similarity NPC329043
0.7701 Intermediate Similarity NPC476412
0.7701 Intermediate Similarity NPC238485
0.7701 Intermediate Similarity NPC473157
0.7701 Intermediate Similarity NPC227132
0.7701 Intermediate Similarity NPC58841
0.7701 Intermediate Similarity NPC161423
0.7701 Intermediate Similarity NPC227064
0.7701 Intermediate Similarity NPC476038
0.7701 Intermediate Similarity NPC194937

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC311092 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.8462 Intermediate Similarity NPD5733 Approved
0.8228 Intermediate Similarity NPD4687 Approved
0.8205 Intermediate Similarity NPD5276 Approved
0.814 Intermediate Similarity NPD5279 Phase 3
0.8118 Intermediate Similarity NPD4786 Approved
0.7882 Intermediate Similarity NPD3667 Approved
0.7848 Intermediate Similarity NPD4747 Approved
0.7778 Intermediate Similarity NPD4058 Approved
0.7727 Intermediate Similarity NPD5280 Approved
0.7727 Intermediate Similarity NPD4694 Approved
0.7722 Intermediate Similarity NPD4137 Phase 3
0.7701 Intermediate Similarity NPD3665 Phase 1
0.7701 Intermediate Similarity NPD3133 Approved
0.7701 Intermediate Similarity NPD3666 Approved
0.7667 Intermediate Similarity NPD5328 Approved
0.7667 Intermediate Similarity NPD4753 Phase 2
0.7625 Intermediate Similarity NPD4691 Approved
0.7595 Intermediate Similarity NPD3621 Clinical (unspecified phase)
0.7528 Intermediate Similarity NPD3618 Phase 1
0.75 Intermediate Similarity NPD6079 Approved
0.7471 Intermediate Similarity NPD4221 Approved
0.7471 Intermediate Similarity NPD4223 Phase 3
0.7416 Intermediate Similarity NPD5329 Approved
0.7412 Intermediate Similarity NPD5784 Clinical (unspecified phase)
0.7333 Intermediate Similarity NPD5690 Phase 2
0.7312 Intermediate Similarity NPD5281 Approved
0.7312 Intermediate Similarity NPD5284 Approved
0.7303 Intermediate Similarity NPD4197 Approved
0.7294 Intermediate Similarity NPD5776 Phase 2
0.7294 Intermediate Similarity NPD6925 Approved
0.7292 Intermediate Similarity NPD6083 Phase 2
0.7292 Intermediate Similarity NPD6084 Phase 2
0.7263 Intermediate Similarity NPD4629 Approved
0.7263 Intermediate Similarity NPD5695 Phase 3
0.7263 Intermediate Similarity NPD5210 Approved
0.7241 Intermediate Similarity NPD7514 Phase 3
0.7234 Intermediate Similarity NPD4202 Approved
0.7234 Intermediate Similarity NPD6399 Phase 3
0.7209 Intermediate Similarity NPD7145 Approved
0.7204 Intermediate Similarity NPD4096 Approved
0.7191 Intermediate Similarity NPD4788 Approved
0.7191 Intermediate Similarity NPD3527 Clinical (unspecified phase)
0.7172 Intermediate Similarity NPD5211 Phase 2
0.7159 Intermediate Similarity NPD4692 Approved
0.7159 Intermediate Similarity NPD4139 Approved
0.7159 Intermediate Similarity NPD6902 Approved
0.7143 Intermediate Similarity NPD4519 Discontinued
0.7143 Intermediate Similarity NPD4689 Approved
0.7143 Intermediate Similarity NPD4693 Phase 3
0.7143 Intermediate Similarity NPD4690 Approved
0.7143 Intermediate Similarity NPD5205 Approved
0.7143 Intermediate Similarity NPD4138 Approved
0.7143 Intermediate Similarity NPD4688 Approved
0.7143 Intermediate Similarity NPD6404 Discontinued
0.7143 Intermediate Similarity NPD4623 Approved
0.7128 Intermediate Similarity NPD7637 Suspended
0.7126 Intermediate Similarity NPD6929 Approved
0.7113 Intermediate Similarity NPD4755 Approved
0.7111 Intermediate Similarity NPD3668 Phase 3
0.7073 Intermediate Similarity NPD6922 Approved
0.7073 Intermediate Similarity NPD6923 Approved
0.7059 Intermediate Similarity NPD7339 Approved
0.7059 Intermediate Similarity NPD6942 Approved
0.7059 Intermediate Similarity NPD8264 Approved
0.7053 Intermediate Similarity NPD5133 Approved
0.7045 Intermediate Similarity NPD6930 Phase 2
0.7045 Intermediate Similarity NPD7332 Phase 2
0.7045 Intermediate Similarity NPD6931 Approved
0.703 Intermediate Similarity NPD5141 Approved
0.7011 Intermediate Similarity NPD7322 Clinical (unspecified phase)
0.7011 Intermediate Similarity NPD3617 Approved
0.701 Intermediate Similarity NPD4697 Phase 3
0.701 Intermediate Similarity NPD5220 Clinical (unspecified phase)
0.701 Intermediate Similarity NPD5221 Approved
0.701 Intermediate Similarity NPD5222 Approved
0.6989 Remote Similarity NPD5737 Approved
0.6989 Remote Similarity NPD4518 Approved
0.6989 Remote Similarity NPD6672 Approved
0.6988 Remote Similarity NPD7144 Approved
0.6988 Remote Similarity NPD7143 Approved
0.697 Remote Similarity NPD4700 Approved
0.697 Remote Similarity NPD5286 Approved
0.697 Remote Similarity NPD5285 Approved
0.697 Remote Similarity NPD4696 Approved
0.6957 Remote Similarity NPD6409 Approved
0.6957 Remote Similarity NPD7146 Approved
0.6957 Remote Similarity NPD6684 Approved
0.6957 Remote Similarity NPD5330 Approved
0.6957 Remote Similarity NPD7521 Approved
0.6957 Remote Similarity NPD7334 Approved
0.6947 Remote Similarity NPD6050 Approved
0.6941 Remote Similarity NPD6926 Approved
0.6941 Remote Similarity NPD6924 Approved
0.6939 Remote Similarity NPD5173 Approved
0.6905 Remote Similarity NPD7150 Approved
0.6905 Remote Similarity NPD7152 Approved
0.6905 Remote Similarity NPD7151 Approved
0.6897 Remote Similarity NPD6932 Approved
0.6869 Remote Similarity NPD5696 Approved
0.6854 Remote Similarity NPD8259 Clinical (unspecified phase)
0.6848 Remote Similarity NPD7520 Clinical (unspecified phase)
0.6842 Remote Similarity NPD5207 Approved
0.6842 Remote Similarity NPD5692 Phase 3
0.6832 Remote Similarity NPD5226 Approved
0.6832 Remote Similarity NPD4633 Approved
0.6832 Remote Similarity NPD5224 Approved
0.6832 Remote Similarity NPD5225 Approved
0.6813 Remote Similarity NPD6695 Phase 3
0.6809 Remote Similarity NPD7513 Clinical (unspecified phase)
0.6809 Remote Similarity NPD6903 Approved
0.6796 Remote Similarity NPD7128 Approved
0.6796 Remote Similarity NPD6402 Approved
0.6796 Remote Similarity NPD6675 Approved
0.6796 Remote Similarity NPD7333 Discontinued
0.6796 Remote Similarity NPD5739 Approved
0.6782 Remote Similarity NPD3701 Clinical (unspecified phase)
0.6782 Remote Similarity NPD6933 Approved
0.6778 Remote Similarity NPD6898 Phase 1
0.6774 Remote Similarity NPD3574 Clinical (unspecified phase)
0.6774 Remote Similarity NPD6098 Approved
0.6771 Remote Similarity NPD6411 Approved
0.6771 Remote Similarity NPD7515 Phase 2
0.6771 Remote Similarity NPD5694 Approved
0.6765 Remote Similarity NPD5174 Approved
0.6765 Remote Similarity NPD5175 Approved
0.6742 Remote Similarity NPD4195 Approved
0.6742 Remote Similarity NPD6683 Phase 2
0.6739 Remote Similarity NPD7338 Clinical (unspecified phase)
0.6737 Remote Similarity NPD7285 Clinical (unspecified phase)
0.6733 Remote Similarity NPD5223 Approved
0.6706 Remote Similarity NPD4243 Approved
0.6702 Remote Similarity NPD4751 Clinical (unspecified phase)
0.6701 Remote Similarity NPD5779 Approved
0.6701 Remote Similarity NPD5778 Approved
0.6667 Remote Similarity NPD6893 Approved
0.6667 Remote Similarity NPD4695 Discontinued
0.6667 Remote Similarity NPD6899 Approved
0.6667 Remote Similarity NPD7525 Registered
0.6667 Remote Similarity NPD1696 Phase 3
0.6667 Remote Similarity NPD7320 Approved
0.6667 Remote Similarity NPD6881 Approved
0.6636 Remote Similarity NPD7115 Discovery
0.6635 Remote Similarity NPD4768 Approved
0.6635 Remote Similarity NPD4767 Approved
0.6634 Remote Similarity NPD7639 Approved
0.6634 Remote Similarity NPD7640 Approved
0.6633 Remote Similarity NPD5769 Clinical (unspecified phase)
0.663 Remote Similarity NPD5362 Discontinued
0.6623 Remote Similarity NPD4219 Approved
0.6604 Remote Similarity NPD6372 Approved
0.6604 Remote Similarity NPD6373 Approved
0.6602 Remote Similarity NPD4754 Approved
0.6588 Remote Similarity NPD4789 Approved
0.6585 Remote Similarity NPD3171 Clinical (unspecified phase)
0.6571 Remote Similarity NPD6412 Phase 2
0.6571 Remote Similarity NPD5701 Approved
0.6571 Remote Similarity NPD5697 Approved
0.6562 Remote Similarity NPD6080 Approved
0.6562 Remote Similarity NPD6904 Approved
0.6562 Remote Similarity NPD6101 Approved
0.6562 Remote Similarity NPD6673 Approved
0.6562 Remote Similarity NPD5764 Clinical (unspecified phase)
0.6552 Remote Similarity NPD4784 Approved
0.6552 Remote Similarity NPD4785 Approved
0.6542 Remote Similarity NPD7102 Approved
0.6542 Remote Similarity NPD7290 Approved
0.6542 Remote Similarity NPD6883 Approved
0.6535 Remote Similarity NPD7638 Approved
0.6526 Remote Similarity NPD7524 Approved
0.6526 Remote Similarity NPD7750 Discontinued
0.6522 Remote Similarity NPD4269 Approved
0.6522 Remote Similarity NPD4270 Approved
0.6512 Remote Similarity NPD4809 Clinical (unspecified phase)
0.6512 Remote Similarity NPD4808 Clinical (unspecified phase)
0.6509 Remote Similarity NPD4729 Approved
0.6509 Remote Similarity NPD4730 Approved
0.6509 Remote Similarity NPD5128 Approved
0.6484 Remote Similarity NPD4252 Approved
0.6481 Remote Similarity NPD6869 Approved
0.6481 Remote Similarity NPD6649 Approved
0.6481 Remote Similarity NPD6617 Approved
0.6481 Remote Similarity NPD8130 Phase 1
0.6481 Remote Similarity NPD6847 Approved
0.6481 Remote Similarity NPD6650 Approved
0.6465 Remote Similarity NPD7748 Approved
0.6458 Remote Similarity NPD5208 Approved
0.6449 Remote Similarity NPD6014 Approved
0.6449 Remote Similarity NPD6013 Approved
0.6449 Remote Similarity NPD6012 Approved
0.6429 Remote Similarity NPD5693 Phase 1
0.6422 Remote Similarity NPD6882 Approved
0.6422 Remote Similarity NPD8297 Approved
0.6413 Remote Similarity NPD8028 Phase 2
0.64 Remote Similarity NPD5654 Approved
0.64 Remote Similarity NPD6356 Clinical (unspecified phase)
0.6395 Remote Similarity NPD4244 Approved
0.6395 Remote Similarity NPD4245 Approved
0.6389 Remote Similarity NPD5249 Phase 3
0.6389 Remote Similarity NPD5247 Approved
0.6389 Remote Similarity NPD5248 Approved

Structure

External Identifiers

PubChem CID   471008
ChEMBL   CHEMBL1915761
ZINC  

Physicochemical Properties

Molecular Weight:  454.34
ALogP:  2.6644
MLogP:  4.43
XLogP:  6.901
# Rotatable Bonds:  14
Polar Surface Area:  57.53
# H-Bond Aceptor:  3
# H-Bond Donor:  2
# Rings:  4
# Heavy Atoms:  33

Download Data

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Biological Activities  
Similar NPs/Drugs