Natural Product: NPC291643

Natural Product ID:  NPC291643
Common Name:   Euphorbiaproliferin C
IUPAC Name:  
Synonyms:   Euphorbiaproliferin C
Molecular Formula:   C32H44O12
Standard InCHIKey:  MEMULCZBXUZFOZ-XBPHKDPRSA-N
Standard InCHI:  InChI=1S/C32H44O12/c1-15(2)27(38)42-24-16(3)13-32(44-20(7)36)23(24)26(40-17(4)33)31-14-39-30(10,28(32)41-18(5)34)25(31)21(11-12-22(31)37)29(8,9)43-19(6)35/h11-12,15-16,21,23-26,28H,13-14H2,1-10H3/t16-,21-,23+,24-,25-,26+,28-,30+,31+,32+/m0/s1
Canonical SMILES:  CC(=O)O[C@@H]1[C@@]2(OC(=O)C)C[C@@H]([C@@H]([C@@H]2[C@H]([C@]23[C@H]([C@@]1(C)OC2)[C@H](C=CC3=O)C(OC(=O)C)(C)C)OC(=O)C)OC(=O)C(C)C)C
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO12377 Euphorbia prolifera Species Euphorbiaceae Eukaryota Roots Kunming, Yunnan Province, China 2010-JUL PMID[21928782]
NPO12377 Euphorbia prolifera Species Euphorbiaceae Eukaryota Root PMID[21928782]

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT519 Cell Line SH-SY5Y Homo sapiens Activity = 68.3 % 21928782
NPT519 Cell Line SH-SY5Y Homo sapiens Activity = 75.4 % 21928782
NPT519 Cell Line SH-SY5Y Homo sapiens Activity = 81.3 % 21928782

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC291643 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.8365 Intermediate Similarity NPC105725
0.8235 Intermediate Similarity NPC113433
0.8224 Intermediate Similarity NPC470192
0.819 Intermediate Similarity NPC78127
0.819 Intermediate Similarity NPC49393
0.819 Intermediate Similarity NPC471757
0.8182 Intermediate Similarity NPC475277
0.8182 Intermediate Similarity NPC473522
0.8182 Intermediate Similarity NPC477093
0.8091 Intermediate Similarity NPC475495
0.8077 Intermediate Similarity NPC470188
0.8061 Intermediate Similarity NPC104961
0.8061 Intermediate Similarity NPC70555
0.8061 Intermediate Similarity NPC70422
0.8039 Intermediate Similarity NPC281775
0.8037 Intermediate Similarity NPC164835
0.8037 Intermediate Similarity NPC228669
0.802 Intermediate Similarity NPC191339
0.802 Intermediate Similarity NPC286341
0.7963 Intermediate Similarity NPC190867
0.7925 Intermediate Similarity NPC171759
0.7895 Intermediate Similarity NPC475305
0.789 Intermediate Similarity NPC26617
0.787 Intermediate Similarity NPC203659
0.787 Intermediate Similarity NPC169843
0.7857 Intermediate Similarity NPC471570
0.785 Intermediate Similarity NPC225353
0.7843 Intermediate Similarity NPC70595
0.7843 Intermediate Similarity NPC221282
0.7843 Intermediate Similarity NPC74103
0.7843 Intermediate Similarity NPC150978
0.7843 Intermediate Similarity NPC123177
0.7838 Intermediate Similarity NPC477103
0.7826 Intermediate Similarity NPC475401
0.7826 Intermediate Similarity NPC473720
0.7822 Intermediate Similarity NPC283409
0.7818 Intermediate Similarity NPC470269
0.781 Intermediate Similarity NPC213947
0.781 Intermediate Similarity NPC170143
0.781 Intermediate Similarity NPC108475
0.7788 Intermediate Similarity NPC209058
0.7788 Intermediate Similarity NPC52634
0.7778 Intermediate Similarity NPC110989
0.7767 Intermediate Similarity NPC477361
0.7767 Intermediate Similarity NPC202824
0.7759 Intermediate Similarity NPC475520
0.7759 Intermediate Similarity NPC477092
0.7759 Intermediate Similarity NPC473203
0.7757 Intermediate Similarity NPC471767
0.7757 Intermediate Similarity NPC477950
0.7748 Intermediate Similarity NPC477102
0.7745 Intermediate Similarity NPC253144
0.7731 Intermediate Similarity NPC473255
0.7723 Intermediate Similarity NPC471149
0.7714 Intermediate Similarity NPC477354
0.7714 Intermediate Similarity NPC91771
0.7714 Intermediate Similarity NPC142529
0.7692 Intermediate Similarity NPC4548
0.7692 Intermediate Similarity NPC474585
0.7685 Intermediate Similarity NPC474747
0.7685 Intermediate Similarity NPC250594
0.7679 Intermediate Similarity NPC471884
0.7672 Intermediate Similarity NPC470420
0.7672 Intermediate Similarity NPC475372
0.767 Intermediate Similarity NPC284185
0.7664 Intermediate Similarity NPC280963
0.7652 Intermediate Similarity NPC54739
0.7647 Intermediate Similarity NPC117405
0.7647 Intermediate Similarity NPC52198
0.7642 Intermediate Similarity NPC47834
0.7636 Intermediate Similarity NPC96377
0.7636 Intermediate Similarity NPC54737
0.7636 Intermediate Similarity NPC223450
0.7624 Intermediate Similarity NPC24728
0.7615 Intermediate Similarity NPC475945
0.7615 Intermediate Similarity NPC475871
0.7611 Intermediate Similarity NPC474750
0.7611 Intermediate Similarity NPC287311
0.7607 Intermediate Similarity NPC5292
0.7607 Intermediate Similarity NPC312536
0.7603 Intermediate Similarity NPC473265
0.7603 Intermediate Similarity NPC470882
0.7596 Intermediate Similarity NPC473273
0.7596 Intermediate Similarity NPC473263
0.7596 Intermediate Similarity NPC477615
0.7596 Intermediate Similarity NPC153590
0.7596 Intermediate Similarity NPC473234
0.7596 Intermediate Similarity NPC60386
0.7596 Intermediate Similarity NPC308656
0.7593 Intermediate Similarity NPC474742
0.7589 Intermediate Similarity NPC304495
0.7589 Intermediate Similarity NPC59489
0.7589 Intermediate Similarity NPC139838
0.7586 Intermediate Similarity NPC36754
0.7586 Intermediate Similarity NPC239273
0.7583 Intermediate Similarity NPC144625
0.757 Intermediate Similarity NPC477355
0.7565 Intermediate Similarity NPC471398
0.7565 Intermediate Similarity NPC138303
0.7565 Intermediate Similarity NPC133677
0.7565 Intermediate Similarity NPC67290
0.7563 Intermediate Similarity NPC107493
0.7547 Intermediate Similarity NPC24956
0.7547 Intermediate Similarity NPC18019
0.7547 Intermediate Similarity NPC126156
0.7547 Intermediate Similarity NPC213078
0.7545 Intermediate Similarity NPC100487
0.7545 Intermediate Similarity NPC474741
0.7545 Intermediate Similarity NPC255309
0.7544 Intermediate Similarity NPC170487
0.7544 Intermediate Similarity NPC471933
0.7542 Intermediate Similarity NPC163693
0.7542 Intermediate Similarity NPC147635
0.7542 Intermediate Similarity NPC143755
0.7525 Intermediate Similarity NPC304558
0.7525 Intermediate Similarity NPC238593
0.7524 Intermediate Similarity NPC289004
0.7522 Intermediate Similarity NPC41551
0.7522 Intermediate Similarity NPC50223
0.7522 Intermediate Similarity NPC257240
0.7521 Intermediate Similarity NPC153440
0.7521 Intermediate Similarity NPC47113
0.7521 Intermediate Similarity NPC161060
0.7521 Intermediate Similarity NPC174367
0.7521 Intermediate Similarity NPC288679
0.75 Intermediate Similarity NPC472769
0.75 Intermediate Similarity NPC117604
0.75 Intermediate Similarity NPC470793
0.75 Intermediate Similarity NPC243981
0.75 Intermediate Similarity NPC186861
0.75 Intermediate Similarity NPC129992
0.748 Intermediate Similarity NPC231529
0.748 Intermediate Similarity NPC13071
0.748 Intermediate Similarity NPC470880
0.748 Intermediate Similarity NPC472770
0.7479 Intermediate Similarity NPC310511
0.7479 Intermediate Similarity NPC46570
0.7479 Intermediate Similarity NPC473228
0.7479 Intermediate Similarity NPC470829
0.7478 Intermediate Similarity NPC46269
0.7478 Intermediate Similarity NPC473535
0.7478 Intermediate Similarity NPC106395
0.7477 Intermediate Similarity NPC477949
0.7477 Intermediate Similarity NPC311904
0.7477 Intermediate Similarity NPC471150
0.7477 Intermediate Similarity NPC87090
0.7477 Intermediate Similarity NPC161493
0.7477 Intermediate Similarity NPC470975
0.7477 Intermediate Similarity NPC103088
0.7477 Intermediate Similarity NPC169205
0.7477 Intermediate Similarity NPC243998
0.7477 Intermediate Similarity NPC470979
0.7477 Intermediate Similarity NPC469874
0.7476 Intermediate Similarity NPC472872
0.7459 Intermediate Similarity NPC473253
0.7459 Intermediate Similarity NPC305496
0.7459 Intermediate Similarity NPC287423
0.7458 Intermediate Similarity NPC472667
0.7456 Intermediate Similarity NPC231589
0.7456 Intermediate Similarity NPC118860
0.7456 Intermediate Similarity NPC214797
0.7455 Intermediate Similarity NPC475873
0.7453 Intermediate Similarity NPC90121
0.7453 Intermediate Similarity NPC163228
0.7453 Intermediate Similarity NPC48803
0.7453 Intermediate Similarity NPC275960
0.7453 Intermediate Similarity NPC193645
0.7453 Intermediate Similarity NPC67584
0.744 Intermediate Similarity NPC224623
0.7436 Intermediate Similarity NPC471146
0.7436 Intermediate Similarity NPC471145
0.7436 Intermediate Similarity NPC473656
0.7434 Intermediate Similarity NPC258543
0.7434 Intermediate Similarity NPC470257
0.7434 Intermediate Similarity NPC241927
0.7431 Intermediate Similarity NPC47880
0.7431 Intermediate Similarity NPC475099
0.7431 Intermediate Similarity NPC477356
0.7431 Intermediate Similarity NPC101067
0.7431 Intermediate Similarity NPC476134
0.7429 Intermediate Similarity NPC472874
0.7429 Intermediate Similarity NPC200237
0.7417 Intermediate Similarity NPC192309
0.7414 Intermediate Similarity NPC473898
0.7414 Intermediate Similarity NPC123117
0.7414 Intermediate Similarity NPC474181
0.7414 Intermediate Similarity NPC471382
0.7414 Intermediate Similarity NPC471380
0.7411 Intermediate Similarity NPC220974
0.7407 Intermediate Similarity NPC153792
0.7407 Intermediate Similarity NPC271387
0.7407 Intermediate Similarity NPC141191
0.7407 Intermediate Similarity NPC54843
0.7404 Intermediate Similarity NPC475748
0.7404 Intermediate Similarity NPC478003
0.7404 Intermediate Similarity NPC478004
0.7404 Intermediate Similarity NPC62815
0.7404 Intermediate Similarity NPC158388
0.74 Intermediate Similarity NPC475622
0.74 Intermediate Similarity NPC108045

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC291643 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.789 Intermediate Similarity NPD7899 Clinical (unspecified phase)
0.7636 Intermediate Similarity NPD6008 Approved
0.7522 Intermediate Similarity NPD6371 Approved
0.7453 Intermediate Similarity NPD1698 Clinical (unspecified phase)
0.7438 Intermediate Similarity NPD7492 Approved
0.7398 Intermediate Similarity NPD7736 Approved
0.7395 Intermediate Similarity NPD6054 Approved
0.7395 Intermediate Similarity NPD6319 Approved
0.7391 Intermediate Similarity NPD8297 Approved
0.7377 Intermediate Similarity NPD6616 Approved
0.7317 Intermediate Similarity NPD7078 Approved
0.7308 Intermediate Similarity NPD1695 Approved
0.7273 Intermediate Similarity NPD6370 Approved
0.7196 Intermediate Similarity NPD5282 Discontinued
0.719 Intermediate Similarity NPD6016 Approved
0.719 Intermediate Similarity NPD6015 Approved
0.7177 Intermediate Similarity NPD8293 Discontinued
0.7155 Intermediate Similarity NPD6650 Approved
0.7155 Intermediate Similarity NPD6649 Approved
0.7131 Intermediate Similarity NPD5988 Approved
0.7129 Intermediate Similarity NPD6435 Approved
0.7107 Intermediate Similarity NPD6059 Approved
0.7094 Intermediate Similarity NPD6053 Discontinued
0.7075 Intermediate Similarity NPD5785 Approved
0.7043 Intermediate Similarity NPD6881 Approved
0.7043 Intermediate Similarity NPD6899 Approved
0.7034 Intermediate Similarity NPD4632 Approved
0.703 Intermediate Similarity NPD5369 Approved
0.7009 Intermediate Similarity NPD8130 Phase 1
0.6983 Remote Similarity NPD6372 Approved
0.6983 Remote Similarity NPD6373 Approved
0.6972 Remote Similarity NPD6356 Clinical (unspecified phase)
0.6957 Remote Similarity NPD5697 Approved
0.6949 Remote Similarity NPD6882 Approved
0.6931 Remote Similarity NPD5368 Approved
0.6923 Remote Similarity NPD7290 Approved
0.6923 Remote Similarity NPD5363 Approved
0.6923 Remote Similarity NPD7102 Approved
0.6923 Remote Similarity NPD6883 Approved
0.6916 Remote Similarity NPD5207 Approved
0.6897 Remote Similarity NPD7320 Approved
0.6887 Remote Similarity NPD6903 Approved
0.687 Remote Similarity NPD7128 Approved
0.687 Remote Similarity NPD6402 Approved
0.687 Remote Similarity NPD6675 Approved
0.687 Remote Similarity NPD5739 Approved
0.6864 Remote Similarity NPD6617 Approved
0.6864 Remote Similarity NPD6847 Approved
0.6864 Remote Similarity NPD6869 Approved
0.686 Remote Similarity NPD6009 Approved
0.6857 Remote Similarity NPD6409 Approved
0.6857 Remote Similarity NPD7334 Approved
0.6857 Remote Similarity NPD5330 Approved
0.6857 Remote Similarity NPD7146 Approved
0.6857 Remote Similarity NPD5786 Approved
0.6857 Remote Similarity NPD7521 Approved
0.6857 Remote Similarity NPD6684 Approved
0.6852 Remote Similarity NPD7983 Approved
0.6838 Remote Similarity NPD6014 Approved
0.6838 Remote Similarity NPD6012 Approved
0.6838 Remote Similarity NPD6013 Approved
0.68 Remote Similarity NPD7604 Phase 2
0.6792 Remote Similarity NPD4250 Approved
0.6792 Remote Similarity NPD4251 Approved
0.678 Remote Similarity NPD4634 Approved
0.6774 Remote Similarity NPD5983 Phase 2
0.6762 Remote Similarity NPD1733 Clinical (unspecified phase)
0.6752 Remote Similarity NPD6011 Approved
0.6729 Remote Similarity NPD7513 Clinical (unspecified phase)
0.6721 Remote Similarity NPD7115 Discovery
0.6698 Remote Similarity NPD4249 Approved
0.6696 Remote Similarity NPD6084 Phase 2
0.6696 Remote Similarity NPD6083 Phase 2
0.6693 Remote Similarity NPD6336 Discontinued
0.6667 Remote Similarity NPD6080 Approved
0.6667 Remote Similarity NPD6412 Phase 2
0.6667 Remote Similarity NPD5695 Phase 3
0.6667 Remote Similarity NPD5701 Approved
0.6667 Remote Similarity NPD7319 Approved
0.6667 Remote Similarity NPD6904 Approved
0.6667 Remote Similarity NPD6673 Approved
0.6637 Remote Similarity NPD5696 Approved
0.6636 Remote Similarity NPD6399 Phase 3
0.6635 Remote Similarity NPD4270 Approved
0.6635 Remote Similarity NPD4269 Approved
0.6589 Remote Similarity NPD8337 Approved
0.6589 Remote Similarity NPD6033 Approved
0.6589 Remote Similarity NPD8336 Approved
0.6579 Remote Similarity NPD5286 Approved
0.6579 Remote Similarity NPD5285 Approved
0.6579 Remote Similarity NPD4696 Approved
0.6577 Remote Similarity NPD6001 Approved
0.6574 Remote Similarity NPD6672 Approved
0.6574 Remote Similarity NPD5737 Approved
0.6562 Remote Similarity NPD7507 Approved
0.6545 Remote Similarity NPD6411 Approved
0.6545 Remote Similarity NPD5281 Approved
0.6545 Remote Similarity NPD5694 Approved
0.6545 Remote Similarity NPD5284 Approved
0.6545 Remote Similarity NPD6050 Approved
0.6515 Remote Similarity NPD8338 Approved
0.6508 Remote Similarity NPD6291 Clinical (unspecified phase)
0.6489 Remote Similarity NPD5956 Approved
0.6486 Remote Similarity NPD5778 Approved
0.6486 Remote Similarity NPD5779 Approved
0.648 Remote Similarity NPD7101 Approved
0.648 Remote Similarity NPD7100 Approved
0.6466 Remote Similarity NPD4633 Approved
0.6466 Remote Similarity NPD5225 Approved
0.6466 Remote Similarity NPD5211 Phase 2
0.6466 Remote Similarity NPD5224 Approved
0.6466 Remote Similarity NPD5226 Approved
0.6455 Remote Similarity NPD46 Approved
0.6455 Remote Similarity NPD6698 Approved
0.6455 Remote Similarity NPD5692 Phase 3
0.6449 Remote Similarity NPD1694 Approved
0.6446 Remote Similarity NPD6401 Clinical (unspecified phase)
0.6442 Remote Similarity NPD5790 Clinical (unspecified phase)
0.6442 Remote Similarity NPD4821 Approved
0.6442 Remote Similarity NPD4822 Approved
0.6442 Remote Similarity NPD4252 Approved
0.6442 Remote Similarity NPD4819 Approved
0.6442 Remote Similarity NPD4820 Approved
0.6422 Remote Similarity NPD5208 Approved
0.6415 Remote Similarity NPD5362 Discontinued
0.641 Remote Similarity NPD5175 Approved
0.641 Remote Similarity NPD6052 Approved
0.641 Remote Similarity NPD5174 Approved
0.6406 Remote Similarity NPD8328 Phase 3
0.6404 Remote Similarity NPD4755 Approved
0.64 Remote Similarity NPD6335 Approved
0.6396 Remote Similarity NPD5693 Phase 1
0.6389 Remote Similarity NPD6098 Approved
0.6379 Remote Similarity NPD5223 Approved
0.6378 Remote Similarity NPD8513 Phase 3
0.6378 Remote Similarity NPD8517 Approved
0.6378 Remote Similarity NPD8515 Approved
0.6378 Remote Similarity NPD8516 Approved
0.6372 Remote Similarity NPD4629 Approved
0.6372 Remote Similarity NPD5210 Approved
0.6371 Remote Similarity NPD6274 Approved
0.6364 Remote Similarity NPD6101 Approved
0.6364 Remote Similarity NPD5764 Clinical (unspecified phase)
0.6356 Remote Similarity NPD5141 Approved
0.6333 Remote Similarity NPD4730 Approved
0.6333 Remote Similarity NPD4729 Approved
0.6333 Remote Similarity NPD6686 Approved
0.632 Remote Similarity NPD6317 Approved
0.6316 Remote Similarity NPD7260 Phase 2
0.6306 Remote Similarity NPD7838 Discovery
0.6293 Remote Similarity NPD4700 Approved
0.6283 Remote Similarity NPD7901 Clinical (unspecified phase)
0.6283 Remote Similarity NPD7900 Approved
0.627 Remote Similarity NPD6313 Approved
0.627 Remote Similarity NPD6314 Approved
0.625 Remote Similarity NPD8033 Approved
0.625 Remote Similarity NPD6614 Approved
0.625 Remote Similarity NPD4271 Approved
0.625 Remote Similarity NPD7637 Suspended
0.625 Remote Similarity NPD6079 Approved
0.625 Remote Similarity NPD5784 Clinical (unspecified phase)
0.625 Remote Similarity NPD4268 Approved
0.6239 Remote Similarity NPD1700 Approved
0.623 Remote Similarity NPD5250 Approved
0.623 Remote Similarity NPD5248 Approved
0.623 Remote Similarity NPD5249 Phase 3
0.623 Remote Similarity NPD5247 Approved
0.623 Remote Similarity NPD5251 Approved
0.6218 Remote Similarity NPD4057 Clinical (unspecified phase)
0.6218 Remote Similarity NPD4056 Clinical (unspecified phase)
0.6216 Remote Similarity NPD4753 Phase 2
0.6207 Remote Similarity NPD8029 Clinical (unspecified phase)
0.6207 Remote Similarity NPD4225 Approved
0.6198 Remote Similarity NPD5345 Clinical (unspecified phase)
0.6182 Remote Similarity NPD3573 Approved
0.6179 Remote Similarity NPD8413 Clinical (unspecified phase)
0.6174 Remote Similarity NPD7839 Suspended
0.6168 Remote Similarity NPD5209 Approved
0.6167 Remote Similarity NPD4767 Approved
0.6167 Remote Similarity NPD4768 Approved
0.6148 Remote Similarity NPD6845 Suspended
0.6136 Remote Similarity NPD8074 Phase 3
0.6124 Remote Similarity NPD6909 Approved
0.6124 Remote Similarity NPD7503 Approved
0.6124 Remote Similarity NPD6908 Approved
0.6121 Remote Similarity NPD7902 Approved
0.6116 Remote Similarity NPD5954 Clinical (unspecified phase)
0.6111 Remote Similarity NPD7154 Phase 3
0.6094 Remote Similarity NPD4522 Approved
0.6091 Remote Similarity NPD3574 Clinical (unspecified phase)
0.6091 Remote Similarity NPD5690 Phase 2
0.6087 Remote Similarity NPD5654 Approved
0.6071 Remote Similarity NPD5328 Approved
0.6068 Remote Similarity NPD7638 Approved
0.6066 Remote Similarity NPD5128 Approved
0.6063 Remote Similarity NPD8295 Clinical (unspecified phase)
0.6055 Remote Similarity NPD3665 Phase 1
0.6055 Remote Similarity NPD3133 Approved
0.6055 Remote Similarity NPD3666 Approved
0.6053 Remote Similarity NPD4202 Approved

Structure

External Identifiers

PubChem CID   56601085
ChEMBL   CHEMBL1927832
ZINC  

Physicochemical Properties

Molecular Weight:  620.28
ALogP:  -0.0595
MLogP:  3.66
XLogP:  2.586
# Rotatable Bonds:  22
Polar Surface Area:  157.8
# H-Bond Aceptor:  12
# H-Bond Donor:  0
# Rings:  4
# Heavy Atoms:  44

Download Data

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General Info & Identifiers & Properties  
Structure MOL file  
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Biological Activities  
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