Natural Product: NPC275243

Natural Product ID:  NPC275243
Common Name:   Uvidin A
IUPAC Name:   (1aR,2aS,6aR,7S,7aR)-7-(hydroxymethyl)-3,3,6a,7a-tetramethyl-1a,2a,4,5,6,7-hexahydronaphtho[2,3-b]oxiren-2-one
Synonyms:  
Molecular Formula:   C15H24O3
Standard InCHIKey:  AHPUPUJYVYUVKA-BRIGZHOFSA-N
Standard InCHI:  InChI=1S/C15H24O3/c1-13(2)6-5-7-14(3)9(8-16)15(4)12(18-15)10(17)11(13)14/h9,11-12,16H,5-8H2,1-4H3/t9-,11+,12+,14-,15-/m1/s1
Canonical SMILES:  OC[C@@H]1[C@@]2(C)CCCC([C@@H]2C(=O)[C@H]2[C@]1(C)O2)(C)C
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO14206 Lactarius uvidus Species Russulaceae Eukaryota PMID[7964786]

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT116 Cell Line HL-60 Homo sapiens Inhibition = 97 % 18809939
NPT176 Organism Artemia salina Artemia salina LC50 = 48.8 ppm 19177635
NPT116 Cell Line HL-60 Homo sapiens Inhibition = 21 % 19177635

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC275243 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.9359 High Similarity NPC475689
0.8831 High Similarity NPC475725
0.8256 Intermediate Similarity NPC477444
0.8256 Intermediate Similarity NPC477433
0.8256 Intermediate Similarity NPC477442
0.8235 Intermediate Similarity NPC477614
0.8235 Intermediate Similarity NPC226491
0.8214 Intermediate Similarity NPC474215
0.8214 Intermediate Similarity NPC475729
0.8202 Intermediate Similarity NPC477264
0.814 Intermediate Similarity NPC477440
0.814 Intermediate Similarity NPC477443
0.8 Intermediate Similarity NPC472984
0.8 Intermediate Similarity NPC120395
0.7976 Intermediate Similarity NPC105895
0.7976 Intermediate Similarity NPC477434
0.7857 Intermediate Similarity NPC227170
0.7857 Intermediate Similarity NPC327451
0.7826 Intermediate Similarity NPC476294
0.7816 Intermediate Similarity NPC90676
0.7816 Intermediate Similarity NPC163296
0.7791 Intermediate Similarity NPC477441
0.7778 Intermediate Similarity NPC309127
0.7778 Intermediate Similarity NPC247877
0.7778 Intermediate Similarity NPC307865
0.7765 Intermediate Similarity NPC25037
0.7765 Intermediate Similarity NPC34984
0.7765 Intermediate Similarity NPC50438
0.7692 Intermediate Similarity NPC17336
0.7683 Intermediate Similarity NPC478084
0.7674 Intermediate Similarity NPC477205
0.7667 Intermediate Similarity NPC474379
0.7654 Intermediate Similarity NPC474020
0.7619 Intermediate Similarity NPC50658
0.7614 Intermediate Similarity NPC236459
0.7586 Intermediate Similarity NPC83242
0.7586 Intermediate Similarity NPC248216
0.7561 Intermediate Similarity NPC143250
0.7561 Intermediate Similarity NPC475031
0.7558 Intermediate Similarity NPC219535
0.7558 Intermediate Similarity NPC237938
0.7558 Intermediate Similarity NPC474996
0.7532 Intermediate Similarity NPC328304
0.7532 Intermediate Similarity NPC329466
0.7531 Intermediate Similarity NPC267753
0.7531 Intermediate Similarity NPC159789
0.7531 Intermediate Similarity NPC68565
0.7531 Intermediate Similarity NPC35871
0.7529 Intermediate Similarity NPC271163
0.7528 Intermediate Similarity NPC61688
0.7527 Intermediate Similarity NPC190080
0.7527 Intermediate Similarity NPC111187
0.75 Intermediate Similarity NPC263802
0.75 Intermediate Similarity NPC62407
0.75 Intermediate Similarity NPC470031
0.75 Intermediate Similarity NPC474755
0.75 Intermediate Similarity NPC287354
0.7471 Intermediate Similarity NPC477445
0.7471 Intermediate Similarity NPC473350
0.7442 Intermediate Similarity NPC15091
0.7442 Intermediate Similarity NPC472847
0.7439 Intermediate Similarity NPC472487
0.7439 Intermediate Similarity NPC472486
0.7439 Intermediate Similarity NPC78935
0.7412 Intermediate Similarity NPC254123
0.7407 Intermediate Similarity NPC317212
0.7407 Intermediate Similarity NPC130011
0.7407 Intermediate Similarity NPC254340
0.7407 Intermediate Similarity NPC133922
0.7386 Intermediate Similarity NPC475276
0.7386 Intermediate Similarity NPC476726
0.7386 Intermediate Similarity NPC476727
0.7375 Intermediate Similarity NPC89310
0.7363 Intermediate Similarity NPC216137
0.7356 Intermediate Similarity NPC319909
0.7356 Intermediate Similarity NPC79308
0.7349 Intermediate Similarity NPC221420
0.7342 Intermediate Similarity NPC131892
0.7342 Intermediate Similarity NPC327728
0.7342 Intermediate Similarity NPC213178
0.7342 Intermediate Similarity NPC6120
0.7333 Intermediate Similarity NPC67653
0.7333 Intermediate Similarity NPC471459
0.7317 Intermediate Similarity NPC125767
0.7317 Intermediate Similarity NPC273366
0.7317 Intermediate Similarity NPC21220
0.7312 Intermediate Similarity NPC477438
0.7312 Intermediate Similarity NPC477437
0.7308 Intermediate Similarity NPC41542
0.7303 Intermediate Similarity NPC202937
0.7303 Intermediate Similarity NPC470920
0.7284 Intermediate Similarity NPC68426
0.7284 Intermediate Similarity NPC282905
0.7284 Intermediate Similarity NPC81759
0.7284 Intermediate Similarity NPC477229
0.7284 Intermediate Similarity NPC232112
0.7283 Intermediate Similarity NPC477436
0.7283 Intermediate Similarity NPC476189
0.7283 Intermediate Similarity NPC477435
0.7253 Intermediate Similarity NPC475211
0.7253 Intermediate Similarity NPC88337
0.7253 Intermediate Similarity NPC476296
0.7234 Intermediate Similarity NPC94337
0.7234 Intermediate Similarity NPC165616
0.7229 Intermediate Similarity NPC475742
0.7229 Intermediate Similarity NPC5767
0.7222 Intermediate Similarity NPC131104
0.7222 Intermediate Similarity NPC471221
0.7222 Intermediate Similarity NPC473319
0.7222 Intermediate Similarity NPC3032
0.7222 Intermediate Similarity NPC476379
0.7215 Intermediate Similarity NPC474954
0.7209 Intermediate Similarity NPC475743
0.7204 Intermediate Similarity NPC293086
0.7204 Intermediate Similarity NPC169751
0.7204 Intermediate Similarity NPC477439
0.7204 Intermediate Similarity NPC272635
0.7195 Intermediate Similarity NPC159325
0.7195 Intermediate Similarity NPC168511
0.7191 Intermediate Similarity NPC80700
0.7191 Intermediate Similarity NPC34190
0.7191 Intermediate Similarity NPC302111
0.7176 Intermediate Similarity NPC320144
0.716 Intermediate Similarity NPC151018
0.716 Intermediate Similarity NPC58057
0.716 Intermediate Similarity NPC473267
0.716 Intermediate Similarity NPC156277
0.716 Intermediate Similarity NPC320549
0.7159 Intermediate Similarity NPC473336
0.7159 Intermediate Similarity NPC471044
0.7158 Intermediate Similarity NPC74466
0.7158 Intermediate Similarity NPC470632
0.7143 Intermediate Similarity NPC24705
0.7143 Intermediate Similarity NPC471151
0.7143 Intermediate Similarity NPC56962
0.7143 Intermediate Similarity NPC200580
0.7143 Intermediate Similarity NPC23884
0.7126 Intermediate Similarity NPC328007
0.7126 Intermediate Similarity NPC317066
0.7126 Intermediate Similarity NPC61107
0.7126 Intermediate Similarity NPC289486
0.7113 Intermediate Similarity NPC112613
0.7108 Intermediate Similarity NPC179858
0.7108 Intermediate Similarity NPC195155
0.7108 Intermediate Similarity NPC174964
0.7108 Intermediate Similarity NPC97534
0.7097 Intermediate Similarity NPC472147
0.7097 Intermediate Similarity NPC472148
0.7093 Intermediate Similarity NPC477851
0.7089 Intermediate Similarity NPC476928
0.7083 Intermediate Similarity NPC253995
0.7083 Intermediate Similarity NPC109059
0.7083 Intermediate Similarity NPC288
0.7073 Intermediate Similarity NPC109510
0.7071 Intermediate Similarity NPC88469
0.7059 Intermediate Similarity NPC185465
0.7059 Intermediate Similarity NPC26029
0.7053 Intermediate Similarity NPC260223
0.7053 Intermediate Similarity NPC193785
0.7053 Intermediate Similarity NPC223169
0.7053 Intermediate Similarity NPC476728
0.7053 Intermediate Similarity NPC235109
0.7053 Intermediate Similarity NPC163685
0.7051 Intermediate Similarity NPC230047
0.7051 Intermediate Similarity NPC19311
0.7045 Intermediate Similarity NPC472744
0.7045 Intermediate Similarity NPC269684
0.7045 Intermediate Similarity NPC64600
0.7041 Intermediate Similarity NPC478176
0.7037 Intermediate Similarity NPC163020
0.7037 Intermediate Similarity NPC476731
0.7033 Intermediate Similarity NPC476435
0.703 Intermediate Similarity NPC153587
0.7027 Intermediate Similarity NPC236588
0.7024 Intermediate Similarity NPC108840
0.7021 Intermediate Similarity NPC329713
0.7021 Intermediate Similarity NPC217567
0.7021 Intermediate Similarity NPC76136
0.7021 Intermediate Similarity NPC212812
0.7019 Intermediate Similarity NPC477266
0.7011 Intermediate Similarity NPC328639
0.7011 Intermediate Similarity NPC329490
0.7011 Intermediate Similarity NPC280781
0.7011 Intermediate Similarity NPC476071
0.7011 Intermediate Similarity NPC48756
0.7011 Intermediate Similarity NPC58631
0.7011 Intermediate Similarity NPC469745
0.7011 Intermediate Similarity NPC328264
0.701 Intermediate Similarity NPC46761
0.7 Intermediate Similarity NPC476717
0.7 Intermediate Similarity NPC470587
0.7 Intermediate Similarity NPC265127
0.6989 Remote Similarity NPC52756
0.6989 Remote Similarity NPC26865
0.6989 Remote Similarity NPC248913
0.6979 Remote Similarity NPC471916
0.697 Remote Similarity NPC131366
0.697 Remote Similarity NPC469985
0.6966 Remote Similarity NPC473299
0.6961 Remote Similarity NPC16657

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC275243 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.7531 Intermediate Similarity NPD3703 Phase 2
0.7342 Intermediate Similarity NPD3699 Clinical (unspecified phase)
0.7342 Intermediate Similarity NPD3700 Clinical (unspecified phase)
0.716 Intermediate Similarity NPD4809 Clinical (unspecified phase)
0.716 Intermediate Similarity NPD4808 Clinical (unspecified phase)
0.7113 Intermediate Similarity NPD1700 Approved
0.7051 Intermediate Similarity NPD3171 Clinical (unspecified phase)
0.7037 Intermediate Similarity NPD4789 Approved
0.6941 Remote Similarity NPD6116 Phase 1
0.6914 Remote Similarity NPD3698 Phase 2
0.6863 Remote Similarity NPD5345 Clinical (unspecified phase)
0.6832 Remote Similarity NPD6675 Approved
0.6832 Remote Similarity NPD7128 Approved
0.6832 Remote Similarity NPD5739 Approved
0.6832 Remote Similarity NPD6402 Approved
0.6829 Remote Similarity NPD4245 Approved
0.6829 Remote Similarity NPD4244 Approved
0.6824 Remote Similarity NPD6117 Approved
0.6804 Remote Similarity NPD4755 Approved
0.679 Remote Similarity NPD5360 Phase 3
0.679 Remote Similarity NPD5361 Clinical (unspecified phase)
0.6786 Remote Similarity NPD6113 Clinical (unspecified phase)
0.6765 Remote Similarity NPD5697 Approved
0.6765 Remote Similarity NPD5701 Approved
0.6706 Remote Similarity NPD3702 Approved
0.6699 Remote Similarity NPD7320 Approved
0.6699 Remote Similarity NPD6899 Approved
0.6699 Remote Similarity NPD6881 Approved
0.6667 Remote Similarity NPD4700 Approved
0.6667 Remote Similarity NPD5286 Approved
0.6667 Remote Similarity NPD4696 Approved
0.6667 Remote Similarity NPD5285 Approved
0.6667 Remote Similarity NPD3671 Phase 1
0.6667 Remote Similarity NPD6114 Approved
0.6667 Remote Similarity NPD6118 Approved
0.6667 Remote Similarity NPD6697 Approved
0.6667 Remote Similarity NPD6115 Approved
0.6635 Remote Similarity NPD6012 Approved
0.6635 Remote Similarity NPD6372 Approved
0.6635 Remote Similarity NPD6013 Approved
0.6635 Remote Similarity NPD6373 Approved
0.6635 Remote Similarity NPD6014 Approved
0.6571 Remote Similarity NPD7290 Approved
0.6571 Remote Similarity NPD7102 Approved
0.6571 Remote Similarity NPD6883 Approved
0.6548 Remote Similarity NPD4758 Discontinued
0.6538 Remote Similarity NPD6011 Approved
0.6535 Remote Similarity NPD5224 Approved
0.6535 Remote Similarity NPD5226 Approved
0.6535 Remote Similarity NPD5225 Approved
0.6535 Remote Similarity NPD4633 Approved
0.6535 Remote Similarity NPD5211 Phase 2
0.6509 Remote Similarity NPD6649 Approved
0.6509 Remote Similarity NPD6847 Approved
0.6509 Remote Similarity NPD6617 Approved
0.6509 Remote Similarity NPD6650 Approved
0.6509 Remote Similarity NPD8130 Phase 1
0.6509 Remote Similarity NPD6869 Approved
0.6471 Remote Similarity NPD5175 Approved
0.6471 Remote Similarity NPD5174 Approved
0.6449 Remote Similarity NPD6882 Approved
0.6449 Remote Similarity NPD8297 Approved
0.6436 Remote Similarity NPD5223 Approved
0.6421 Remote Similarity NPD5328 Approved
0.6415 Remote Similarity NPD4634 Approved
0.6408 Remote Similarity NPD5141 Approved
0.6364 Remote Similarity NPD5220 Clinical (unspecified phase)
0.6364 Remote Similarity NPD5222 Approved
0.6364 Remote Similarity NPD5221 Approved
0.6364 Remote Similarity NPD4697 Phase 3
0.6355 Remote Similarity NPD6401 Clinical (unspecified phase)
0.6353 Remote Similarity NPD5777 Approved
0.6346 Remote Similarity NPD4768 Approved
0.6346 Remote Similarity NPD4767 Approved
0.6341 Remote Similarity NPD4224 Phase 2
0.6339 Remote Similarity NPD6059 Approved
0.6339 Remote Similarity NPD6319 Approved
0.6339 Remote Similarity NPD6054 Approved
0.6311 Remote Similarity NPD4754 Approved
0.631 Remote Similarity NPD4267 Clinical (unspecified phase)
0.63 Remote Similarity NPD5173 Approved
0.6296 Remote Similarity NPD371 Approved
0.6289 Remote Similarity NPD6079 Approved
0.6283 Remote Similarity NPD6015 Approved
0.6283 Remote Similarity NPD6016 Approved
0.6277 Remote Similarity NPD3618 Phase 1
0.6273 Remote Similarity NPD6274 Approved
0.6228 Remote Similarity NPD5988 Approved
0.6228 Remote Similarity NPD6370 Approved
0.6226 Remote Similarity NPD4729 Approved
0.6226 Remote Similarity NPD4730 Approved
0.6226 Remote Similarity NPD5128 Approved
0.6224 Remote Similarity NPD4202 Approved
0.6216 Remote Similarity NPD8295 Clinical (unspecified phase)
0.6196 Remote Similarity NPD3667 Approved
0.617 Remote Similarity NPD7520 Clinical (unspecified phase)
0.614 Remote Similarity NPD6921 Approved
0.6139 Remote Similarity NPD6084 Phase 2
0.6139 Remote Similarity NPD6083 Phase 2
0.6122 Remote Similarity NPD8035 Phase 2
0.6122 Remote Similarity NPD8034 Phase 2
0.6121 Remote Similarity NPD7492 Approved
0.6111 Remote Similarity NPD5249 Phase 3
0.6111 Remote Similarity NPD5248 Approved
0.6111 Remote Similarity NPD5247 Approved
0.6111 Remote Similarity NPD5251 Approved
0.6111 Remote Similarity NPD5250 Approved
0.6111 Remote Similarity NPD5364 Discontinued
0.6106 Remote Similarity NPD7100 Approved
0.6106 Remote Similarity NPD7101 Approved
0.6095 Remote Similarity NPD8170 Clinical (unspecified phase)
0.6082 Remote Similarity NPD4753 Phase 2
0.6071 Remote Similarity NPD6317 Approved
0.6068 Remote Similarity NPD6616 Approved
0.6064 Remote Similarity NPD4786 Approved
0.6055 Remote Similarity NPD5217 Approved
0.6055 Remote Similarity NPD5215 Approved
0.6055 Remote Similarity NPD5216 Approved
0.6034 Remote Similarity NPD8328 Phase 3
0.6019 Remote Similarity NPD4061 Clinical (unspecified phase)
0.6018 Remote Similarity NPD6313 Approved
0.6018 Remote Similarity NPD6335 Approved
0.6018 Remote Similarity NPD6314 Approved
0.6017 Remote Similarity NPD7078 Approved
0.6017 Remote Similarity NPD8293 Discontinued
0.6 Remote Similarity NPD6908 Approved
0.6 Remote Similarity NPD6909 Approved
0.6 Remote Similarity NPD7748 Approved
0.6 Remote Similarity NPD229 Approved
0.598 Remote Similarity NPD7902 Approved
0.5977 Remote Similarity NPD6081 Approved
0.5966 Remote Similarity NPD7736 Approved
0.5963 Remote Similarity NPD5135 Approved
0.5963 Remote Similarity NPD5169 Approved
0.5963 Remote Similarity NPD5134 Clinical (unspecified phase)
0.596 Remote Similarity NPD6411 Approved
0.596 Remote Similarity NPD7515 Phase 2
0.5957 Remote Similarity NPD4788 Approved
0.5946 Remote Similarity NPD4632 Approved
0.5941 Remote Similarity NPD5695 Phase 3
0.5938 Remote Similarity NPD3574 Clinical (unspecified phase)
0.5934 Remote Similarity NPD3617 Approved
0.5929 Remote Similarity NPD7115 Discovery
0.5929 Remote Similarity NPD6009 Approved
0.5922 Remote Similarity NPD5696 Approved
0.5909 Remote Similarity NPD5127 Approved
0.59 Remote Similarity NPD6399 Phase 3
0.5897 Remote Similarity NPD7604 Phase 2
0.5895 Remote Similarity NPD3666 Approved
0.5895 Remote Similarity NPD3133 Approved
0.5895 Remote Similarity NPD3665 Phase 1
0.589 Remote Similarity NPD385 Approved
0.589 Remote Similarity NPD384 Approved
0.5888 Remote Similarity NPD6008 Approved
0.5876 Remote Similarity NPD3573 Approved
0.5862 Remote Similarity NPD5983 Phase 2
0.5862 Remote Similarity NPD4787 Phase 1
0.5841 Remote Similarity NPD6868 Approved
0.5833 Remote Similarity NPD6033 Approved
0.5818 Remote Similarity NPD5955 Clinical (unspecified phase)
0.5784 Remote Similarity NPD4629 Approved
0.5784 Remote Similarity NPD5210 Approved
0.578 Remote Similarity NPD5168 Approved
0.5773 Remote Similarity NPD5279 Phase 3
0.5769 Remote Similarity NPD615 Clinical (unspecified phase)
0.5758 Remote Similarity NPD5764 Clinical (unspecified phase)
0.5758 Remote Similarity NPD6101 Approved
0.5752 Remote Similarity NPD5167 Approved
0.5745 Remote Similarity NPD1780 Approved
0.5745 Remote Similarity NPD1779 Approved
0.5729 Remote Similarity NPD4197 Approved
0.5727 Remote Similarity NPD8132 Clinical (unspecified phase)
0.5726 Remote Similarity NPD6291 Clinical (unspecified phase)
0.5699 Remote Similarity NPD7645 Phase 2
0.5686 Remote Similarity NPD5282 Discontinued
0.5686 Remote Similarity NPD7900 Approved
0.5686 Remote Similarity NPD7901 Clinical (unspecified phase)
0.567 Remote Similarity NPD1696 Phase 3
0.567 Remote Similarity NPD5329 Approved
0.5667 Remote Similarity NPD6336 Discontinued
0.5657 Remote Similarity NPD6672 Approved
0.5657 Remote Similarity NPD5737 Approved
0.5647 Remote Similarity NPD9496 Clinical (unspecified phase)
0.5638 Remote Similarity NPD6928 Phase 2
0.5638 Remote Similarity NPD4695 Discontinued
0.5638 Remote Similarity NPD7525 Registered
0.5619 Remote Similarity NPD4225 Approved
0.5612 Remote Similarity NPD6098 Approved

Structure

External Identifiers

PubChem CID   156765
ChEMBL   CHEMBL458313
ZINC  

Physicochemical Properties

Molecular Weight:  252.17
ALogP:  -0.2967
MLogP:  2.78
XLogP:  2.834
# Rotatable Bonds:  6
Polar Surface Area:  49.83
# H-Bond Aceptor:  3
# H-Bond Donor:  1
# Rings:  3
# Heavy Atoms:  18

Download Data

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General Info & Identifiers & Properties  
Structure MOL file  
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Biological Activities  
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