Natural Product: NPC248913

Natural Product ID:  NPC248913
Common Name:   Sodwanone B
IUPAC Name:   (4aR)-5-[2-[(5aS,6R,7R,9aS)-2,2,5a,7-tetramethyl-3-oxo-5,6,7,8,9,9a-hexahydro-4H-benzo[b]oxepin-6-yl]ethyl]-8-hydroxy-1,1,4a,6-tetramethyl-3,4-dihydronaphthalene-2,7-dione
Synonyms:  
Molecular Formula:   C30H44O5
Standard InCHIKey:  VTXYSDPCTJDOCW-PGNQREQFSA-N
Standard InCHI:  InChI=1S/C30H44O5/c1-17-9-12-23-29(7,15-14-22(32)28(5,6)35-23)19(17)10-11-20-18(2)24(33)25(34)26-27(3,4)21(31)13-16-30(20,26)8/h17,19,23,34H,9-16H2,1-8H3/t17-,19-,23+,29+,30-/m1/s1
Canonical SMILES:  O=C1C(=C(CC[C@@H]2[C@H](C)CC[C@H]3[C@@]2(C)CCC(=O)C(O3)(C)C)[C@@]2(C(=C1O)C(C)(C)C(=O)CC2)C)C
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO32663 Axinella Genus Axinellidae Eukaryota South African PMID[17190448]

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT2 Others Unspecified IC50 > 30000 nM PubChem BioAssay data set
NPT82 Cell Line MDA-MB-231 Homo sapiens IC50 > 30000 nM 8759172
NPT2 Others Unspecified IC50 > 30000 nM 17325223
NPT90 Cell Line DU-145 Homo sapiens IC50 > 30000 nM 21962987
NPT306 Cell Line PC-3 Homo sapiens IC50 > 30000 nM 23398362
NPT2 Others Unspecified IC50 > 30000 nM 19222165
NPT396 Cell Line T47D Homo sapiens IC50 > 30000 nM PubChem BioAssay data set

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC248913 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.977 High Similarity NPC212812
0.9419 High Similarity NPC185059
0.9419 High Similarity NPC475001
0.8696 High Similarity NPC477439
0.8696 High Similarity NPC293086
0.8602 High Similarity NPC477438
0.8602 High Similarity NPC477437
0.8587 High Similarity NPC477435
0.8587 High Similarity NPC477436
0.837 Intermediate Similarity NPC475823
0.837 Intermediate Similarity NPC474209
0.8367 Intermediate Similarity NPC179208
0.8352 Intermediate Similarity NPC230387
0.8283 Intermediate Similarity NPC40170
0.8256 Intermediate Similarity NPC476808
0.8247 Intermediate Similarity NPC472972
0.8222 Intermediate Similarity NPC197823
0.8172 Intermediate Similarity NPC113393
0.8172 Intermediate Similarity NPC223093
0.8125 Intermediate Similarity NPC91439
0.8105 Intermediate Similarity NPC23170
0.8105 Intermediate Similarity NPC474328
0.8105 Intermediate Similarity NPC472976
0.8105 Intermediate Similarity NPC472977
0.809 Intermediate Similarity NPC48362
0.8085 Intermediate Similarity NPC168027
0.8085 Intermediate Similarity NPC185936
0.8085 Intermediate Similarity NPC472975
0.8085 Intermediate Similarity NPC472978
0.8085 Intermediate Similarity NPC99380
0.8081 Intermediate Similarity NPC80781
0.8065 Intermediate Similarity NPC472973
0.8061 Intermediate Similarity NPC46761
0.8022 Intermediate Similarity NPC6185
0.8022 Intermediate Similarity NPC241512
0.8022 Intermediate Similarity NPC478245
0.8021 Intermediate Similarity NPC473170
0.8 Intermediate Similarity NPC33973
0.8 Intermediate Similarity NPC211230
0.8 Intermediate Similarity NPC70967
0.8 Intermediate Similarity NPC194323
0.798 Intermediate Similarity NPC124211
0.7957 Intermediate Similarity NPC307298
0.7938 Intermediate Similarity NPC305483
0.7938 Intermediate Similarity NPC96859
0.7938 Intermediate Similarity NPC328162
0.7921 Intermediate Similarity NPC216245
0.7921 Intermediate Similarity NPC213366
0.7921 Intermediate Similarity NPC135854
0.7921 Intermediate Similarity NPC470251
0.7921 Intermediate Similarity NPC137657
0.7921 Intermediate Similarity NPC2436
0.7917 Intermediate Similarity NPC160413
0.7917 Intermediate Similarity NPC196485
0.7917 Intermediate Similarity NPC245972
0.79 Intermediate Similarity NPC53222
0.7895 Intermediate Similarity NPC111883
0.7879 Intermediate Similarity NPC88198
0.7872 Intermediate Similarity NPC474245
0.7872 Intermediate Similarity NPC250592
0.7872 Intermediate Similarity NPC68148
0.7872 Intermediate Similarity NPC77263
0.7872 Intermediate Similarity NPC65615
0.7857 Intermediate Similarity NPC18509
0.7857 Intermediate Similarity NPC473456
0.7857 Intermediate Similarity NPC470834
0.7849 Intermediate Similarity NPC272039
0.7849 Intermediate Similarity NPC220930
0.7843 Intermediate Similarity NPC478052
0.7841 Intermediate Similarity NPC30321
0.7835 Intermediate Similarity NPC474602
0.7835 Intermediate Similarity NPC317586
0.7835 Intermediate Similarity NPC470016
0.7835 Intermediate Similarity NPC200702
0.7826 Intermediate Similarity NPC263997
0.7826 Intermediate Similarity NPC470574
0.7826 Intermediate Similarity NPC8518
0.7826 Intermediate Similarity NPC132228
0.7826 Intermediate Similarity NPC474680
0.7822 Intermediate Similarity NPC90177
0.7822 Intermediate Similarity NPC470839
0.7822 Intermediate Similarity NPC275583
0.7816 Intermediate Similarity NPC92080
0.7812 Intermediate Similarity NPC271652
0.7812 Intermediate Similarity NPC79117
0.781 Intermediate Similarity NPC43775
0.7802 Intermediate Similarity NPC64600
0.78 Intermediate Similarity NPC469327
0.7789 Intermediate Similarity NPC472325
0.7767 Intermediate Similarity NPC44063
0.7767 Intermediate Similarity NPC202524
0.7766 Intermediate Similarity NPC158778
0.7766 Intermediate Similarity NPC131470
0.7766 Intermediate Similarity NPC328539
0.7766 Intermediate Similarity NPC472802
0.7766 Intermediate Similarity NPC143767
0.7755 Intermediate Similarity NPC272411
0.7755 Intermediate Similarity NPC260223
0.7755 Intermediate Similarity NPC192428
0.7753 Intermediate Similarity NPC475681
0.7753 Intermediate Similarity NPC192329
0.7745 Intermediate Similarity NPC65523
0.7742 Intermediate Similarity NPC94666
0.7742 Intermediate Similarity NPC73038
0.7742 Intermediate Similarity NPC158393
0.7736 Intermediate Similarity NPC90769
0.7736 Intermediate Similarity NPC474516
0.7732 Intermediate Similarity NPC166906
0.7732 Intermediate Similarity NPC240617
0.7732 Intermediate Similarity NPC74751
0.7723 Intermediate Similarity NPC119601
0.7723 Intermediate Similarity NPC308726
0.7723 Intermediate Similarity NPC163249
0.7708 Intermediate Similarity NPC73457
0.7708 Intermediate Similarity NPC155304
0.7708 Intermediate Similarity NPC473166
0.77 Intermediate Similarity NPC112167
0.77 Intermediate Similarity NPC157787
0.77 Intermediate Similarity NPC144956
0.7692 Intermediate Similarity NPC103486
0.7684 Intermediate Similarity NPC86319
0.7684 Intermediate Similarity NPC275740
0.7684 Intermediate Similarity NPC31985
0.7684 Intermediate Similarity NPC1015
0.7677 Intermediate Similarity NPC216904
0.7677 Intermediate Similarity NPC43747
0.767 Intermediate Similarity NPC181357
0.767 Intermediate Similarity NPC32006
0.767 Intermediate Similarity NPC85529
0.7667 Intermediate Similarity NPC2482
0.7667 Intermediate Similarity NPC18955
0.766 Intermediate Similarity NPC472324
0.766 Intermediate Similarity NPC475740
0.766 Intermediate Similarity NPC241875
0.766 Intermediate Similarity NPC469317
0.766 Intermediate Similarity NPC298904
0.766 Intermediate Similarity NPC469314
0.7653 Intermediate Similarity NPC280725
0.7653 Intermediate Similarity NPC139570
0.7653 Intermediate Similarity NPC272617
0.7653 Intermediate Similarity NPC134067
0.7647 Intermediate Similarity NPC264048
0.7647 Intermediate Similarity NPC131366
0.7642 Intermediate Similarity NPC34315
0.7634 Intermediate Similarity NPC133652
0.7634 Intermediate Similarity NPC90287
0.7634 Intermediate Similarity NPC32037
0.7634 Intermediate Similarity NPC79573
0.7629 Intermediate Similarity NPC295643
0.7629 Intermediate Similarity NPC12722
0.7629 Intermediate Similarity NPC214756
0.7629 Intermediate Similarity NPC272075
0.7629 Intermediate Similarity NPC274046
0.7629 Intermediate Similarity NPC198074
0.7624 Intermediate Similarity NPC472643
0.7624 Intermediate Similarity NPC302537
0.7624 Intermediate Similarity NPC163372
0.7624 Intermediate Similarity NPC470184
0.7619 Intermediate Similarity NPC20192
0.7619 Intermediate Similarity NPC77947
0.7619 Intermediate Similarity NPC27814
0.7619 Intermediate Similarity NPC87335
0.7619 Intermediate Similarity NPC2766
0.7619 Intermediate Similarity NPC286174
0.7609 Intermediate Similarity NPC105803
0.7604 Intermediate Similarity NPC183283
0.7604 Intermediate Similarity NPC474728
0.7604 Intermediate Similarity NPC38952
0.76 Intermediate Similarity NPC112753
0.76 Intermediate Similarity NPC478056
0.76 Intermediate Similarity NPC275439
0.76 Intermediate Similarity NPC17183
0.7596 Intermediate Similarity NPC475294
0.7596 Intermediate Similarity NPC144854
0.7596 Intermediate Similarity NPC3316
0.7593 Intermediate Similarity NPC473798
0.7582 Intermediate Similarity NPC473217
0.7582 Intermediate Similarity NPC55869
0.7579 Intermediate Similarity NPC53454
0.7579 Intermediate Similarity NPC53911
0.7579 Intermediate Similarity NPC471722
0.7579 Intermediate Similarity NPC143025
0.7579 Intermediate Similarity NPC474925
0.7579 Intermediate Similarity NPC206060
0.7576 Intermediate Similarity NPC471463
0.7576 Intermediate Similarity NPC469545
0.7576 Intermediate Similarity NPC21681
0.7576 Intermediate Similarity NPC249954
0.7576 Intermediate Similarity NPC62516
0.7576 Intermediate Similarity NPC157113
0.7576 Intermediate Similarity NPC95565
0.7576 Intermediate Similarity NPC61369
0.7576 Intermediate Similarity NPC5532
0.7576 Intermediate Similarity NPC471822
0.7576 Intermediate Similarity NPC472675
0.7576 Intermediate Similarity NPC472734
0.7576 Intermediate Similarity NPC472733
0.757 Intermediate Similarity NPC193948
0.757 Intermediate Similarity NPC234042
0.757 Intermediate Similarity NPC147180

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC248913 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.802 Intermediate Similarity NPD6402 Approved
0.802 Intermediate Similarity NPD6675 Approved
0.802 Intermediate Similarity NPD7128 Approved
0.802 Intermediate Similarity NPD5739 Approved
0.7872 Intermediate Similarity NPD5328 Approved
0.7865 Intermediate Similarity NPD4695 Discontinued
0.7864 Intermediate Similarity NPD6881 Approved
0.7864 Intermediate Similarity NPD6899 Approved
0.7864 Intermediate Similarity NPD7320 Approved
0.7857 Intermediate Similarity NPD4755 Approved
0.7788 Intermediate Similarity NPD6372 Approved
0.7788 Intermediate Similarity NPD6373 Approved
0.7767 Intermediate Similarity NPD5697 Approved
0.7767 Intermediate Similarity NPD5701 Approved
0.7755 Intermediate Similarity NPD5220 Clinical (unspecified phase)
0.7755 Intermediate Similarity NPD4697 Phase 3
0.7755 Intermediate Similarity NPD5221 Approved
0.7755 Intermediate Similarity NPD5222 Approved
0.7732 Intermediate Similarity NPD7748 Approved
0.7714 Intermediate Similarity NPD6883 Approved
0.7714 Intermediate Similarity NPD7102 Approved
0.7714 Intermediate Similarity NPD7290 Approved
0.7708 Intermediate Similarity NPD6079 Approved
0.77 Intermediate Similarity NPD4700 Approved
0.77 Intermediate Similarity NPD5286 Approved
0.77 Intermediate Similarity NPD4696 Approved
0.77 Intermediate Similarity NPD5285 Approved
0.7692 Intermediate Similarity NPD6011 Approved
0.7677 Intermediate Similarity NPD5173 Approved
0.7642 Intermediate Similarity NPD8130 Phase 1
0.7642 Intermediate Similarity NPD6617 Approved
0.7642 Intermediate Similarity NPD6650 Approved
0.7642 Intermediate Similarity NPD6401 Clinical (unspecified phase)
0.7642 Intermediate Similarity NPD6847 Approved
0.7642 Intermediate Similarity NPD6649 Approved
0.7642 Intermediate Similarity NPD6869 Approved
0.764 Intermediate Similarity NPD3617 Approved
0.7624 Intermediate Similarity NPD5223 Approved
0.7619 Intermediate Similarity NPD6013 Approved
0.7619 Intermediate Similarity NPD6014 Approved
0.7619 Intermediate Similarity NPD6012 Approved
0.757 Intermediate Similarity NPD6882 Approved
0.757 Intermediate Similarity NPD8297 Approved
0.7553 Intermediate Similarity NPD3618 Phase 1
0.7549 Intermediate Similarity NPD5226 Approved
0.7549 Intermediate Similarity NPD5225 Approved
0.7549 Intermediate Similarity NPD4633 Approved
0.7549 Intermediate Similarity NPD5224 Approved
0.7549 Intermediate Similarity NPD5211 Phase 2
0.7526 Intermediate Similarity NPD7515 Phase 2
0.75 Intermediate Similarity NPD6084 Phase 2
0.75 Intermediate Similarity NPD6083 Phase 2
0.75 Intermediate Similarity NPD7902 Approved
0.7476 Intermediate Similarity NPD5175 Approved
0.7476 Intermediate Similarity NPD4754 Approved
0.7476 Intermediate Similarity NPD5174 Approved
0.7404 Intermediate Similarity NPD5141 Approved
0.7396 Intermediate Similarity NPD5737 Approved
0.7396 Intermediate Similarity NPD6672 Approved
0.734 Intermediate Similarity NPD4786 Approved
0.7333 Intermediate Similarity NPD4768 Approved
0.7333 Intermediate Similarity NPD4767 Approved
0.732 Intermediate Similarity NPD4753 Phase 2
0.732 Intermediate Similarity NPD7285 Clinical (unspecified phase)
0.7312 Intermediate Similarity NPD3667 Approved
0.73 Intermediate Similarity NPD5695 Phase 3
0.7292 Intermediate Similarity NPD3573 Approved
0.7273 Intermediate Similarity NPD6399 Phase 3
0.7273 Intermediate Similarity NPD4202 Approved
0.7263 Intermediate Similarity NPD5329 Approved
0.7255 Intermediate Similarity NPD5696 Approved
0.7232 Intermediate Similarity NPD6335 Approved
0.7207 Intermediate Similarity NPD6274 Approved
0.7207 Intermediate Similarity NPD6868 Approved
0.72 Intermediate Similarity NPD7901 Clinical (unspecified phase)
0.72 Intermediate Similarity NPD7900 Approved
0.7196 Intermediate Similarity NPD5128 Approved
0.7196 Intermediate Similarity NPD4730 Approved
0.7196 Intermediate Similarity NPD4729 Approved
0.7188 Intermediate Similarity NPD5279 Phase 3
0.7188 Intermediate Similarity NPD3574 Clinical (unspecified phase)
0.7168 Intermediate Similarity NPD7100 Approved
0.7168 Intermediate Similarity NPD7101 Approved
0.7158 Intermediate Similarity NPD3666 Approved
0.7158 Intermediate Similarity NPD3133 Approved
0.7158 Intermediate Similarity NPD3665 Phase 1
0.7158 Intermediate Similarity NPD4197 Approved
0.7143 Intermediate Similarity NPD6317 Approved
0.7143 Intermediate Similarity NPD6080 Approved
0.7143 Intermediate Similarity NPD6904 Approved
0.7143 Intermediate Similarity NPD6673 Approved
0.7105 Intermediate Similarity NPD6054 Approved
0.7105 Intermediate Similarity NPD6059 Approved
0.708 Intermediate Similarity NPD6313 Approved
0.708 Intermediate Similarity NPD6314 Approved
0.7064 Intermediate Similarity NPD5249 Phase 3
0.7064 Intermediate Similarity NPD5251 Approved
0.7064 Intermediate Similarity NPD4634 Approved
0.7064 Intermediate Similarity NPD5248 Approved
0.7064 Intermediate Similarity NPD5135 Approved
0.7064 Intermediate Similarity NPD5134 Clinical (unspecified phase)
0.7064 Intermediate Similarity NPD5247 Approved
0.7064 Intermediate Similarity NPD5169 Approved
0.7064 Intermediate Similarity NPD5250 Approved
0.7059 Intermediate Similarity NPD7341 Phase 2
0.7043 Intermediate Similarity NPD6909 Approved
0.7043 Intermediate Similarity NPD6908 Approved
0.7037 Intermediate Similarity NPD5168 Approved
0.7027 Intermediate Similarity NPD4632 Approved
0.701 Intermediate Similarity NPD6684 Approved
0.701 Intermediate Similarity NPD7521 Approved
0.701 Intermediate Similarity NPD6409 Approved
0.701 Intermediate Similarity NPD7334 Approved
0.701 Intermediate Similarity NPD5330 Approved
0.701 Intermediate Similarity NPD7146 Approved
0.7009 Intermediate Similarity NPD6008 Approved
0.7 Intermediate Similarity NPD5215 Approved
0.7 Intermediate Similarity NPD5217 Approved
0.7 Intermediate Similarity NPD5216 Approved
0.7 Intermediate Similarity NPD5127 Approved
0.7 Intermediate Similarity NPD6411 Approved
0.6991 Remote Similarity NPD6009 Approved
0.6983 Remote Similarity NPD6370 Approved
0.6979 Remote Similarity NPD3668 Phase 3
0.6961 Remote Similarity NPD5210 Approved
0.6961 Remote Similarity NPD4629 Approved
0.6957 Remote Similarity NPD6319 Approved
0.6947 Remote Similarity NPD4223 Phase 3
0.6947 Remote Similarity NPD4221 Approved
0.6923 Remote Similarity NPD7604 Phase 2
0.6915 Remote Similarity NPD8259 Clinical (unspecified phase)
0.6897 Remote Similarity NPD6015 Approved
0.6897 Remote Similarity NPD6016 Approved
0.6897 Remote Similarity NPD5983 Phase 2
0.6869 Remote Similarity NPD6903 Approved
0.6869 Remote Similarity NPD7513 Clinical (unspecified phase)
0.6864 Remote Similarity NPD7492 Approved
0.6842 Remote Similarity NPD8295 Clinical (unspecified phase)
0.6838 Remote Similarity NPD5988 Approved
0.6837 Remote Similarity NPD6098 Approved
0.6837 Remote Similarity NPD4694 Approved
0.6837 Remote Similarity NPD5280 Approved
0.6837 Remote Similarity NPD5690 Phase 2
0.6832 Remote Similarity NPD5693 Phase 1
0.6832 Remote Similarity NPD6050 Approved
0.6814 Remote Similarity NPD5167 Approved
0.6807 Remote Similarity NPD6616 Approved
0.6807 Remote Similarity NPD6336 Discontinued
0.68 Remote Similarity NPD6101 Approved
0.68 Remote Similarity NPD5764 Clinical (unspecified phase)
0.6796 Remote Similarity NPD6356 Clinical (unspecified phase)
0.6782 Remote Similarity NPD3704 Approved
0.678 Remote Similarity NPD8328 Phase 3
0.6762 Remote Similarity NPD7638 Approved
0.6752 Remote Similarity NPD6291 Clinical (unspecified phase)
0.675 Remote Similarity NPD8293 Discontinued
0.675 Remote Similarity NPD7078 Approved
0.6733 Remote Similarity NPD5692 Phase 3
0.6701 Remote Similarity NPD4788 Approved
0.6699 Remote Similarity NPD5282 Discontinued
0.6698 Remote Similarity NPD7640 Approved
0.6698 Remote Similarity NPD7639 Approved
0.6696 Remote Similarity NPD7115 Discovery
0.6694 Remote Similarity NPD6033 Approved
0.6694 Remote Similarity NPD7736 Approved
0.6667 Remote Similarity NPD4690 Approved
0.6667 Remote Similarity NPD8034 Phase 2
0.6667 Remote Similarity NPD4689 Approved
0.6667 Remote Similarity NPD4623 Approved
0.6667 Remote Similarity NPD4138 Approved
0.6667 Remote Similarity NPD4688 Approved
0.6667 Remote Similarity NPD8035 Phase 2
0.6667 Remote Similarity NPD4519 Discontinued
0.6667 Remote Similarity NPD5205 Approved
0.6667 Remote Similarity NPD4693 Phase 3
0.6667 Remote Similarity NPD4061 Clinical (unspecified phase)
0.6667 Remote Similarity NPD5694 Approved
0.6632 Remote Similarity NPD7645 Phase 2
0.6607 Remote Similarity NPD5955 Clinical (unspecified phase)
0.6591 Remote Similarity NPD7331 Phase 2
0.6577 Remote Similarity NPD5345 Clinical (unspecified phase)
0.6574 Remote Similarity NPD7632 Discontinued
0.6566 Remote Similarity NPD7520 Clinical (unspecified phase)
0.6566 Remote Similarity NPD1696 Phase 3
0.6562 Remote Similarity NPD7525 Registered
0.6559 Remote Similarity NPD3703 Phase 2
0.6518 Remote Similarity NPD8132 Clinical (unspecified phase)
0.6495 Remote Similarity NPD4139 Approved
0.6495 Remote Similarity NPD4692 Approved
0.6491 Remote Similarity NPD6053 Discontinued
0.6486 Remote Similarity NPD6412 Phase 2
0.6476 Remote Similarity NPD5654 Approved
0.6449 Remote Similarity NPD4225 Approved
0.6442 Remote Similarity NPD5778 Approved
0.6442 Remote Similarity NPD5779 Approved
0.6442 Remote Similarity NPD5133 Approved
0.6429 Remote Similarity NPD4752 Clinical (unspecified phase)
0.6429 Remote Similarity NPD4800 Clinical (unspecified phase)
0.6415 Remote Similarity NPD7614 Phase 1
0.6413 Remote Similarity NPD4808 Clinical (unspecified phase)

Structure

External Identifiers

PubChem CID   21773186
ChEMBL   CHEMBL492187
ZINC  

Physicochemical Properties

Molecular Weight:  484.32
ALogP:  2.0636
MLogP:  4.21
XLogP:  5.104
# Rotatable Bonds:  12
Polar Surface Area:  80.67
# H-Bond Aceptor:  5
# H-Bond Donor:  1
# Rings:  4
# Heavy Atoms:  35

Download Data

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General Info & Identifiers & Properties  
Structure MOL file  
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Biological Activities  
Similar NPs/Drugs