Similar Natural Products in NPASS
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient 
● The left chart: Distribution of similarity level between NPC170434 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.56 or Top200).
| range |
Tanimoto Coefficient |
| 0-0.1 | 20384 |
| 0.1-0.2 | 9626 |
| 0.2-0.3 | 744 |
| 0.3-0.4 | 102 |
| 0.4-0.5 | 24 |
| 0.5-0.6 | 7 |
| 0.6-0.7 | 1 |
| 0.7-0.8 | 1 |
| 0.8-0.85 | 0 |
| 0.85-0.9 | 0 |
| 0.9-0.95 | 0 |
| 0.95-1 | 0 |
| Similarity Score |
Similarity Level |
Natural Product ID |
| 0.7143 |
Intermediate Similarity |
NPC127355 |
| 0.625 |
Remote Similarity |
NPC319797 |
| 0.5882
|
Remote Similarity |
NPC150271 |
Similar Clinical/Approved Drugs
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.
● The left chart: Distribution of similarity level between NPC170434 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).
| range |
Tanimoto Coefficient |
| 0-0.1 | 7379 |
| 0.1-0.2 | 1605 |
| 0.2-0.3 | 166 |
| 0.3-0.4 | 7 |
| 0.4-0.5 | 4 |
| 0.5-0.6 | 0 |
| 0.6-0.7 | 0 |
| 0.7-0.8 | 0 |
| 0.8-0.85 | 0 |
| 0.85-0.9 | 0 |
| 0.9-0.95 | 0 |
| 0.95-1 | 0 |
| Similarity Score |
Similarity Level |
Drug ID |
Developmental Stage |
|
|
NPD
|
|
